#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P70347-1	uniprotkb:P39429	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:16826(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:72677D758DC7F9D3|rigid:zasCBbUD5WsoMLSoNC5925q7ak4	false	sufficient binding region:318-334	sufficient binding region:293-501	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62406-1	uniprotkb:P70196	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655584	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:14620(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:26570531E021085E|rigid:NcTkqDpX3fuJqYwrtGBR9nF1dy0	false	sufficient binding region:503-690	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WV80	uniprotkb:O88351	intact:EBI-646356|uniprotkb:Q9EQZ9	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:snx1_mouse(display_long)|uniprotkb:Snx1(gene name)|psi-mi:Snx1(display_short)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656032	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR028660|refseq:NP_062701.2|interpro:IPR001683(Phox-like)|interpro:IPR005329(Sorting nexin, N-terminal)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR034901|mint:Q9WV80|interpro:IPR036871|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098793"(presynapse)|go:"GO:0098999"(extrinsic component of postsynaptic endosome membrane)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030904"(retromer complex)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:18246(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Yf/oVE8cR+cYTTplNaxj/OwjMWg10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:C688DEA328A785F9|rigid:5emDb0sIk2xkDn6yIxrVWKYE8dA	false	sufficient binding region:319-343	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0DMN7	uniprotkb:P98083	intact:EBI-644529|uniprotkb:P31154|uniprotkb:P82184|uniprotkb:Q58E47|ensembl:ENSMUSP00000097528|ensembl:ENSMUSP00000159133	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:dcam1_mouse(display_long)|uniprotkb:Amd1(gene name)|psi-mi:Amd1(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652478	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033795.1|ensembl:ENSMUSG00000075232(gene)|ensembl:ENSMUST00000099945(transcript)|ensembl:ENSMUST00000238969(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004014"(adenosylmethionine decarboxylase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006557"(S-adenosylmethioninamine biosynthetic process)|go:"GO:0006597"(spermine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0019810"(putrescine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001985(S-adenosylmethionine decarboxylase)|interpro:IPR016067(S-adenosylmethionine decarboxylase, core)|interpro:IPR018166|mint:P0DMN7|reactome:R-MMU-351202	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:15663(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:C6CwoFWtQAiWB9f5Y+g8jKU0b9g10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:33E61545801482D5|rigid:9oGTPpgkS8E2pdYoS37BLmxR8+M	false	sufficient binding region:128-330	sufficient binding region:1-341	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EQ32	uniprotkb:Q9Z0R4-1	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	intact:EBI-645405|intact:EBI-7583879|intact:EBI-7583665|intact:MINT-86526|ensembl:ENSMUSP00000109635	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:q9z0r4-1(display_long)|uniprotkb:Ese1L(isoform synonym)|uniprotkb:Itsn1(gene name)|psi-mi:Itsn1(display_short)|uniprotkb:Ese1(gene name synonym)|uniprotkb:Itsn(gene name synonym)|uniprotkb:EH and SH3 domains protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654271	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	intact:EBI-645386(itsn1_mouse)|ensembl:ENSMUSG00000022957(gene)|ensembl:ENSMUST00000114002(transcript)	afcs:30681(primary-reference)|afcs:16257(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	rogid:naFu4D6P1S+/t5+VVVeb0De8lEg10090	intact-crc:C248955DCF2723FF|rigid:X57IPlzKMpdshx86m9RfpvKk9fE	false	sufficient binding region:600-811	sufficient binding region:694-1138	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CG79	uniprotkb:Q9EQ32	intact:EBI-645416|uniprotkb:Q3UYM7|uniprotkb:Q8K2L5	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	psi-mi:aspp2_mouse(display_long)|uniprotkb:Tumor suppressor p53-binding protein 2(gene name synonym)|uniprotkb:Tp53bp2(gene name)|psi-mi:Tp53bp2(display_short)|uniprotkb:Aspp2(gene name synonym)|uniprotkb:Trp53bp2(gene name synonym)	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654281	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_775554.2|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR001452(Src homology-3)|interpro:IPR029071|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007049"(cell cycle)|go:"GO:0007417"(central nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0009792"(embryo development ending in birth or egg hatching)|go:"GO:0010212"(response to ionizing radiation)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030054"(cell junction)|go:"GO:0042802"(identical protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1900119"(positive regulation of execution phase of apoptosis)|go:"GO:1901216"(positive regulation of neuron death)|interpro:IPR036028|interpro:IPR036770|reactome:R-MMU-6804759	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	afcs:30681(primary-reference)|afcs:50599(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Ygl3S/FVLP/3gD2F0o5t016B2Bk10090	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	intact-crc:D6274E3F31E4FD83|rigid:HJFNecUjCUrX0akgTNI2hxCmFdg	false	sufficient binding region:906-1088	sufficient binding region:600-811	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02248	uniprotkb:P26450	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654301	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:13985(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:8CB64DBF60320656|rigid:VGpWE4wkzzBCxeY+GGX1LXKFp7k	false	sufficient binding region:435-781	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654311	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:423D5853087203A0|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:336-651	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654341	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:2F561B532F793E8F|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:372-651	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654351	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:3B7E08F6DFFFF44A|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:406-651	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-682314	uniprotkb:P98083	-	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:ptn12-afcs_mouse(display_short)|psi-mi:EBI-682314(display_long)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688378	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:31945(primary-reference)|afcs:31945(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"similar to mouse P35831 Tyrosine-protein phosphatase, non-receptor type 12 (EC 3.1.3.48)(Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST)."|comment:"AfCS Y2H protein. Sequence deduced from cross-reference:protein GI:416182"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3BZoZqaw5Ee46QUmraUZLnpbGGY10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:EAFD8ED301863263|rigid:IzUdgqMluJufWD4zNNCS7yYB/TM	false	sufficient binding region:510-773	sufficient binding region:1-341	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70196	uniprotkb:Q62406-1	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655605	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:6999(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:7939D00B557DEB53|rigid:NcTkqDpX3fuJqYwrtGBR9nF1dy0	false	sufficient binding region:392-530	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P39429	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655788	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:53738(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:7A10BD439DFB7E95|rigid:GKDnIiX2Gz1ltIGmNRWyCFYCe84	false	sufficient binding region:1-91	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02535	uniprotkb:Q60680-1	intact:EBI-646288|uniprotkb:P08731|uniprotkb:Q8BUX3|uniprotkb:Q8BV09|uniprotkb:Q8BVU3|uniprotkb:Q9CXH6|uniprotkb:Q9JKB4	intact:EBI-646260	psi-mi:k1c10_mouse(display_long)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:56 kDa cytokeratin(gene name synonym)|uniprotkb:Keratin, type I cytoskeletal 59 kDa(gene name synonym)|uniprotkb:Krt10(gene name)|psi-mi:Krt10(display_short)|uniprotkb:Krt1-10(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655859	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034790.2|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|mint:P02535|go:"GO:0003334"(keratinocyte development)|go:"GO:0005198"(structural molecule activity)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009986"(cell surface)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0071277"(cellular response to calcium ion)|reactome:R-MMU-6805567|reactome:R-MMU-6809371	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:50632(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/a3BFQt80FodMtWZiNH14TCythg10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:76353C471CA76035|rigid:MfvK/gLS2Gly9q7GkgYN+vtCZpM	false	sufficient binding region:143-427	sufficient binding region:310-551	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02535	uniprotkb:Q60680-1	intact:EBI-646288|uniprotkb:P08731|uniprotkb:Q8BUX3|uniprotkb:Q8BV09|uniprotkb:Q8BVU3|uniprotkb:Q9CXH6|uniprotkb:Q9JKB4	intact:EBI-646260	psi-mi:k1c10_mouse(display_long)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:56 kDa cytokeratin(gene name synonym)|uniprotkb:Keratin, type I cytoskeletal 59 kDa(gene name synonym)|uniprotkb:Krt10(gene name)|psi-mi:Krt10(display_short)|uniprotkb:Krt1-10(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655890	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034790.2|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|mint:P02535|go:"GO:0003334"(keratinocyte development)|go:"GO:0005198"(structural molecule activity)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009986"(cell surface)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0071277"(cellular response to calcium ion)|reactome:R-MMU-6805567|reactome:R-MMU-6809371	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:50632(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/a3BFQt80FodMtWZiNH14TCythg10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:77198F1ED507A45F|rigid:MfvK/gLS2Gly9q7GkgYN+vtCZpM	false	sufficient binding region:143-342	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02535	uniprotkb:Q60680-1	intact:EBI-646288|uniprotkb:P08731|uniprotkb:Q8BUX3|uniprotkb:Q8BV09|uniprotkb:Q8BVU3|uniprotkb:Q9CXH6|uniprotkb:Q9JKB4	intact:EBI-646260	psi-mi:k1c10_mouse(display_long)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:56 kDa cytokeratin(gene name synonym)|uniprotkb:Keratin, type I cytoskeletal 59 kDa(gene name synonym)|uniprotkb:Krt10(gene name)|psi-mi:Krt10(display_short)|uniprotkb:Krt1-10(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655910	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034790.2|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|mint:P02535|go:"GO:0003334"(keratinocyte development)|go:"GO:0005198"(structural molecule activity)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009986"(cell surface)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0071277"(cellular response to calcium ion)|reactome:R-MMU-6805567|reactome:R-MMU-6809371	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:50632(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/a3BFQt80FodMtWZiNH14TCythg10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:F640D73BEDD12655|rigid:MfvK/gLS2Gly9q7GkgYN+vtCZpM	false	sufficient binding region:161-462	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O09012	uniprotkb:Q60680-1	intact:EBI-646301|uniprotkb:Q3UM58|uniprotkb:Q8K2V5|uniprotkb:Q91YC7|ensembl:ENSMUSP00000049132|ensembl:ENSMUSP00000108151	intact:EBI-646260	psi-mi:pex5_mouse(display_long)|uniprotkb:Peroxisome receptor 1(gene name synonym)|uniprotkb:Peroxisomal C-terminal targeting signal import receptor(gene name synonym)|uniprotkb:PTS1-BP(gene name synonym)|uniprotkb:Peroxin-5(gene name synonym)|uniprotkb:PXR1P(gene name synonym)|uniprotkb:Pex5(gene name)|psi-mi:Pex5(display_short)|uniprotkb:Pxr1(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655941	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033021.2|refseq:NP_787947.1|refseq:NP_001264734.1|refseq:XP_006505821.1|refseq:XP_006505822.1|refseq:NP_001264259.1|refseq:XP_017176951.1|ensembl:ENSMUSG00000005069(gene)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007031"(peroxisome organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|ensembl:ENSMUST00000035861(transcript)|ensembl:ENSMUST00000112532(transcript)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0016561"(protein import into peroxisome matrix, translocation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051262"(protein tetramerization)|go:"GO:0140311"(protein sequestering activity)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR024111|interpro:IPR024113|reactome:R-MMU-8866654|go:"GO:0000038"(very long-chain fatty acid metabolic process)|reactome:R-MMU-9033241|reactome:R-MMU-9664873|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0001764"(neuron migration)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:15136(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:GqfIILxRcIiR64Sc7t0ElWui3dw10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:0F04C9889CEDB551|rigid:u+Pb+9LA42j0n5yv2sJ0putliyU	false	sufficient binding region:226-352	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80UK0	uniprotkb:Q60680-1	intact:EBI-646282|uniprotkb:Q3TLJ1|uniprotkb:Q810W3|uniprotkb:Q8CI09|ensembl:ENSMUSP00000099720|ensembl:ENSMUSP00000099721	intact:EBI-646260	psi-mi:sesd1_mouse(display_long)|uniprotkb:Sestd1(gene name)|psi-mi:Sestd1(display_short)|uniprotkb:Huntingtin-interacting protein-like protein(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655849	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_780674.1|refseq:XP_006499263.1|refseq:XP_006499264.1|refseq:XP_006499265.1|ensembl:ENSMUSG00000042272(gene)|ensembl:ENSMUST00000102659(transcript)|ensembl:ENSMUST00000102660(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:55488(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:6vT+co7M/u3no7+pSYJLpvahLEA10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:F613A2CEB97C4446|rigid:XsH7EcJ//568YHeC1EhmdijLaf4	false	sufficient binding region:134-430	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60680-1	uniprotkb:Q8BP22	intact:EBI-646260	intact:EBI-646638|uniprotkb:A2AVA5|uniprotkb:A2AVA6|uniprotkb:A2AVA7|uniprotkb:Q7TNQ9|uniprotkb:Q8C2F8|uniprotkb:Q8VDU6|uniprotkb:Q9D2J3|ensembl:ENSMUSP00000103920	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:fa92a_mouse(display_long)|uniprotkb:Fam92a(gene name)|psi-mi:Fam92a(display_short)|uniprotkb:Fam92a1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656560	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646245(ikka_mouse)	refseq:NP_080834.3|refseq:NP_001297672.1|ensembl:ENSMUSG00000028218(gene)|ensembl:ENSMUST00000108285(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|go:"GO:0097546"(ciliary base)|go:"GO:0097749"(membrane tubulation)|interpro:IPR009602(Protein of unknown function DUF1208)|interpro:IPR027267|interpro:IPR035590	afcs:14057(primary-reference)|afcs:53781(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rogid:YOOxBao5mTGCEUIpIPPmZsDpmR010090	intact-crc:A014AA0588598300|rigid:OJljcgo412kvYgwyobKQ49DSDg8	false	sufficient binding region:400-650	sufficient binding region:79-196	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BP22	uniprotkb:Q60680-1	intact:EBI-646638|uniprotkb:A2AVA5|uniprotkb:A2AVA6|uniprotkb:A2AVA7|uniprotkb:Q7TNQ9|uniprotkb:Q8C2F8|uniprotkb:Q8VDU6|uniprotkb:Q9D2J3|ensembl:ENSMUSP00000103920	intact:EBI-646260	psi-mi:fa92a_mouse(display_long)|uniprotkb:Fam92a(gene name)|psi-mi:Fam92a(display_short)|uniprotkb:Fam92a1(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080834.3|refseq:NP_001297672.1|ensembl:ENSMUSG00000028218(gene)|ensembl:ENSMUST00000108285(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|go:"GO:0097546"(ciliary base)|go:"GO:0097749"(membrane tubulation)|interpro:IPR009602(Protein of unknown function DUF1208)|interpro:IPR027267|interpro:IPR035590	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:53781(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YOOxBao5mTGCEUIpIPPmZsDpmR010090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:415631A47D172091|rigid:OJljcgo412kvYgwyobKQ49DSDg8	false	sufficient binding region:?-?	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BP22	uniprotkb:Q60680-1	intact:EBI-646638|uniprotkb:A2AVA5|uniprotkb:A2AVA6|uniprotkb:A2AVA7|uniprotkb:Q7TNQ9|uniprotkb:Q8C2F8|uniprotkb:Q8VDU6|uniprotkb:Q9D2J3|ensembl:ENSMUSP00000103920	intact:EBI-646260	psi-mi:fa92a_mouse(display_long)|uniprotkb:Fam92a(gene name)|psi-mi:Fam92a(display_short)|uniprotkb:Fam92a1(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656580	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080834.3|refseq:NP_001297672.1|ensembl:ENSMUSG00000028218(gene)|ensembl:ENSMUST00000108285(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|go:"GO:0097546"(ciliary base)|go:"GO:0097749"(membrane tubulation)|interpro:IPR009602(Protein of unknown function DUF1208)|interpro:IPR027267|interpro:IPR035590	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:53781(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YOOxBao5mTGCEUIpIPPmZsDpmR010090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:E5DCF44C7E6A242B|rigid:OJljcgo412kvYgwyobKQ49DSDg8	false	sufficient binding region:86-243	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q924A0	uniprotkb:P39428	intact:EBI-646713|uniprotkb:O70574|uniprotkb:Q91XP2|uniprotkb:Q91XP3|uniprotkb:Q91XP4|uniprotkb:Q924A1|uniprotkb:Q9Z0V3|uniprotkb:Q9Z0V4|uniprotkb:Q8C834	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:tf7l2_mouse(display_long)|uniprotkb:HMG box transcription factor 4(gene name synonym)|uniprotkb:T-cell-specific transcription factor 4(gene name synonym)|uniprotkb:Tcf7l2(gene name)|psi-mi:Tcf7l2(display_short)|uniprotkb:Tcf4(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656973	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001136393.1|refseq:NP_001136396.1|dip:DIP-40920N|refseq:NP_001136390.1|mint:Q924A0|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030282"(bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030538"(embryonic genitalia morphogenesis)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032350"(regulation of hormone metabolic process)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0043588"(skin development)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0048641"(regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0071664"(catenin-TCF7L2 complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR036910|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-4641265|reactome:R-MMU-8853884|reactome:R-MMU-8951430|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:15412(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sg7QuRHMz8m1+v07Fmk+iPachlw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:B8003B1F156290DA|rigid:SAp2ddgMruSp2irgtdD9Vs+GqfY	false	sufficient binding region:22-241	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q924A0	uniprotkb:P39428	intact:EBI-646713|uniprotkb:O70574|uniprotkb:Q91XP2|uniprotkb:Q91XP3|uniprotkb:Q91XP4|uniprotkb:Q924A1|uniprotkb:Q9Z0V3|uniprotkb:Q9Z0V4|uniprotkb:Q8C834	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:tf7l2_mouse(display_long)|uniprotkb:HMG box transcription factor 4(gene name synonym)|uniprotkb:T-cell-specific transcription factor 4(gene name synonym)|uniprotkb:Tcf7l2(gene name)|psi-mi:Tcf7l2(display_short)|uniprotkb:Tcf4(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656983	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001136393.1|refseq:NP_001136396.1|dip:DIP-40920N|refseq:NP_001136390.1|mint:Q924A0|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030282"(bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030538"(embryonic genitalia morphogenesis)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032350"(regulation of hormone metabolic process)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0043588"(skin development)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0048641"(regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0071664"(catenin-TCF7L2 complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR036910|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-4641265|reactome:R-MMU-8853884|reactome:R-MMU-8951430|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:15412(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sg7QuRHMz8m1+v07Fmk+iPachlw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:AECA139372488035|rigid:SAp2ddgMruSp2irgtdD9Vs+GqfY	false	sufficient binding region:30-196	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q924A0	uniprotkb:P39428	intact:EBI-646713|uniprotkb:O70574|uniprotkb:Q91XP2|uniprotkb:Q91XP3|uniprotkb:Q91XP4|uniprotkb:Q924A1|uniprotkb:Q9Z0V3|uniprotkb:Q9Z0V4|uniprotkb:Q8C834	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:tf7l2_mouse(display_long)|uniprotkb:HMG box transcription factor 4(gene name synonym)|uniprotkb:T-cell-specific transcription factor 4(gene name synonym)|uniprotkb:Tcf7l2(gene name)|psi-mi:Tcf7l2(display_short)|uniprotkb:Tcf4(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657003	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001136393.1|refseq:NP_001136396.1|dip:DIP-40920N|refseq:NP_001136390.1|mint:Q924A0|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030282"(bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030538"(embryonic genitalia morphogenesis)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032350"(regulation of hormone metabolic process)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0043588"(skin development)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0048641"(regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0071664"(catenin-TCF7L2 complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR036910|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-4641265|reactome:R-MMU-8853884|reactome:R-MMU-8951430|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:15412(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sg7QuRHMz8m1+v07Fmk+iPachlw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:A20C87597C4EE9C4|rigid:SAp2ddgMruSp2irgtdD9Vs+GqfY	false	sufficient binding region:76-225	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q924A0	uniprotkb:P39428	intact:EBI-646713|uniprotkb:O70574|uniprotkb:Q91XP2|uniprotkb:Q91XP3|uniprotkb:Q91XP4|uniprotkb:Q924A1|uniprotkb:Q9Z0V3|uniprotkb:Q9Z0V4|uniprotkb:Q8C834	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:tf7l2_mouse(display_long)|uniprotkb:HMG box transcription factor 4(gene name synonym)|uniprotkb:T-cell-specific transcription factor 4(gene name synonym)|uniprotkb:Tcf7l2(gene name)|psi-mi:Tcf7l2(display_short)|uniprotkb:Tcf4(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657023	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001136393.1|refseq:NP_001136396.1|dip:DIP-40920N|refseq:NP_001136390.1|mint:Q924A0|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030282"(bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030538"(embryonic genitalia morphogenesis)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032350"(regulation of hormone metabolic process)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0043588"(skin development)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0048641"(regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0071664"(catenin-TCF7L2 complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR036910|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-4641265|reactome:R-MMU-8853884|reactome:R-MMU-8951430|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:15412(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sg7QuRHMz8m1+v07Fmk+iPachlw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:DE2B1425F60E5FB0|rigid:SAp2ddgMruSp2irgtdD9Vs+GqfY	false	sufficient binding region:91-321	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11103	uniprotkb:P39428	intact:EBI-642213|uniprotkb:Q9JLX4|uniprotkb:Q9QVQ3	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:parp1_mouse(display_long)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Parp1(gene name)|psi-mi:Parp1(display_short)|uniprotkb:Adprp(gene name synonym)|uniprotkb:Adprt(gene name synonym)|uniprotkb:Adprt1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657033	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|reactome:R-MMU-110362|reactome:R-MMU-2173795|reactome:R-MMU-3108214|reactome:R-MMU-5685939|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0034644"(cellular response to UV)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071451"(cellular response to superoxide)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903516"(regulation of single strand break repair)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1903827"|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:0070212"(protein poly-ADP-ribosylation)|mint:P11103|dip:DIP-39371N	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:13787(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZJY1aTtD8Cz198SVs9FDdUSli7s10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:C78EBFABA75F0706|rigid:s0w7TphPCaB7lIQlDMsebWR3MfA	false	sufficient binding region:638-786	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1J1	uniprotkb:P39428	intact:EBI-646762|uniprotkb:O70450|uniprotkb:O70573	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:tf7l1_mouse(display_long)|uniprotkb:HMG box transcription factor 3(gene name synonym)|uniprotkb:Tcf7l1(gene name)|psi-mi:Tcf7l1(display_short)|uniprotkb:Tcf3(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657043	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033358.2|dip:DIP-49605N|interpro:IPR027397|interpro:IPR028778|interpro:IPR036910|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008595"(anterior/posterior axis specification, embryo)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0043588"(skin development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048319"(axial mesoderm morphogenesis)|go:"GO:0048863"(stem cell differentiation)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4641265|reactome:R-MMU-8951430|reactome:R-MMU-4086398|reactome:R-MMU-8853884	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:15411(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:l/DKng9W5qg5AQVpnfjPVIfaE+w10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:68A09B4A6A1E8B8D|rigid:hvX2LSkHIbeSB6Qd5wn9O4lKbrg	false	sufficient binding region:26-228	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657124	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:7F1B96BB5AED6E30|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:148-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657164	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:D05F259D5300EDF3|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:174-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657194	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:706682E16553004C|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:214-360	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657224	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:84989D2AEE512CC6|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:262-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:C496EAF0C472A206|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:52-246	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657294	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:79CC316A0E7C4B74|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:58-254	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657304	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:19E18484FD0B3240|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:60-280	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657374	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:9A0356A265D2E8CC|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:177-280	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14602-1	uniprotkb:P42227	intact:EBI-432240|ensembl:ENSMUSP00000005077	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:p14602-1(display_long)|uniprotkb:Hspb1(gene name)|psi-mi:Hspb1(display_short)|uniprotkb:Hsp25(gene name synonym)|uniprotkb:Hsp27(gene name synonym)|uniprotkb:Growth-related 25 kDa protein(gene name synonym)|uniprotkb:Heat shock 25 kDa protein(gene name synonym)|uniprotkb:Heat shock 27 kDa protein(gene name synonym)|uniprotkb:p25(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657394	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000004951(gene)|ensembl:ENSMUST00000005077(transcript)|intact:EBI-299023(hspb1_mouse)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:17274(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c79cDHl0WGQlEO7vGeDaZfr2oAE10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:42633662E7F6A7EE|rigid:zuqlEtelxUQQ7lraJ3WCiNgB8eo	false	sufficient binding region:41-208	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04104	uniprotkb:P42227	intact:EBI-646772|uniprotkb:Q149E0|uniprotkb:Q9D2K8|ensembl:ENSMUSP00000023790	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:k2c1_mouse(display_long)|uniprotkb:Cytokeratin-1(gene name synonym)|uniprotkb:67 kDa cytokeratin(gene name synonym)|uniprotkb:Type-II keratin Kb1(gene name synonym)|uniprotkb:Krt1(gene name)|psi-mi:Krt1(display_short)|uniprotkb:Krt2-1(gene name synonym)|uniprotkb:Keratin-1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657404	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032499.2|interpro:IPR018039|interpro:IPR032444|interpro:IPR032449|interpro:IPR039008|mint:P04104|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|interpro:IPR003054(Type II keratin)|ensembl:ENSMUSG00000046834(gene)|ensembl:ENSMUST00000023790(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001867"(complement activation, lectin pathway)|go:"GO:0016020"(membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030280"(structural constituent of skin epidermis)|go:"GO:0045095"(keratin filament)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0061436"(establishment of skin barrier)|go:"GO:0062023"(collagen-containing extracellular matrix)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:9125(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:STENVj6SpzelAzNtQzl9kalt7cs10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:775976BDFBB9407F|rigid:3AFK4eRzSDt06r96M4XADhflSWE	false	sufficient binding region:208-548	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99KX1	uniprotkb:P42227	intact:EBI-646781|ensembl:ENSMUSP00000032214|ensembl:ENSMUSP00000135920	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:mlf2_mouse(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:Mlf2(gene name)|psi-mi:Mlf2(display_short)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657424	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001163812.1|refseq:NP_663360.1|ensembl:ENSMUSG00000030120(gene)|ensembl:ENSMUST00000032214(transcript)|ensembl:ENSMUST00000180095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR019376|mint:Q99KX1	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:58076(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/TTRBTfO7JkzWbvIALSR+GeA5aU10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:7B1960726BACEA18|rigid:adSjUDcCmlHQs2LsnAT+LC6M9/8	false	sufficient binding region:6-214	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TMY8	uniprotkb:P42227	intact:EBI-646786|uniprotkb:A2AFQ1|uniprotkb:Q4G2Z1|uniprotkb:Q5BMM7|uniprotkb:Q6NS61|uniprotkb:Q8BNJ7|uniprotkb:Q8CFH2|uniprotkb:Q8VD14|uniprotkb:Q921M5|uniprotkb:Q9R0P2|ensembl:ENSMUSP00000108241	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:huwe1_mouse(display_long)|uniprotkb:HECT, UBA and WWE domain-containing protein 1(gene name synonym)|uniprotkb:Upstream regulatory element-binding protein 1(gene name synonym)|uniprotkb:E3Histone(gene name synonym)|uniprotkb:Huwe1(gene name)|psi-mi:Huwe1(display_short)|uniprotkb:Kiaa0312(gene name synonym)|uniprotkb:Ureb1(gene name synonym)|uniprotkb:HECT-type E3 ubiquitin transferase HUWE1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657434	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067498.4|ensembl:ENSMUSG00000025261(gene)|ensembl:ENSMUST00000112622(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006284"(base-excision repair)|go:"GO:0006513"(protein monoubiquitination)|go:"GO:0007030"(Golgi organization)|go:"GO:0010637"(negative regulation of mitochondrial fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016574"(histone ubiquitination)|go:"GO:0030154"(cell differentiation)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0061025"(membrane fusion)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098779"(positive regulation of mitophagy in response to mitochondrial depolarization)|interpro:IPR000569(HECT)|interpro:IPR004170(WWE)|interpro:IPR009060(UBA-like)|interpro:IPR010309(E3 ubiquitin ligase, region of unknown function DUF908)|interpro:IPR010314(E3 ubiquitin ligase, region of unknown function DUF913)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025527|interpro:IPR035983|interpro:IPR037197|interpro:IPR041918|mint:Q7TMY8|reactome:R-MMU-6798695|reactome:R-MMU-983168	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:35048(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bfiYTxkedQUu7pdjryOi5z+tYP410090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:433850AA71DF7531|rigid:scaxf4sTAzE4lAR9qxg/27bSgNg	false	sufficient binding region:1883-2102	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:B7ZNY0	uniprotkb:Q60680-1	intact:EBI-659248	intact:EBI-646260	psi-mi:b7zny0_mouse(display_long)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688423	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR010630(Protein of unknown function DUF1220)|interpro:IPR012943(Spindle associated)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:55507(primary-reference)|afcs:55507(secondary-ac)	caution:"Protein [uniprotkb:B7ZNY0] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"	-	caution:"Protein [uniprotkb:B7ZNY0] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:eiXGlR7tV0/mwnWc7nDJyyvzwFI10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:5A859E868CE6BC45|rigid:BMBdsns7XMZ9sj9t5INqk8IJcL4	false	sufficient binding region:?-?	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60680-1	uniprotkb:B7ZNY0	intact:EBI-646260	intact:EBI-659248	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:b7zny0_mouse(display_long)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688458	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646245(ikka_mouse)	interpro:IPR010630(Protein of unknown function DUF1220)|interpro:IPR012943(Spindle associated)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)	afcs:14057(primary-reference)|afcs:55507(primary-reference)|afcs:55507(secondary-ac)	-	caution:"Protein [uniprotkb:B7ZNY0] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"	caution:"Protein [uniprotkb:B7ZNY0] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rogid:eiXGlR7tV0/mwnWc7nDJyyvzwFI10090	intact-crc:A15497EA91173C4B|rigid:BMBdsns7XMZ9sj9t5INqk8IJcL4	false	sufficient binding region:400-650	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-687980	uniprotkb:P63085	afcs:58422	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mll2_mouse_protein(display_short)|psi-mi:EBI-687980(display_long)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688480	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:58122(secondary-ac)|afcs:58122(primary-reference)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"similar to human Myeloid/lymphoid or mixed-lineage leukemia protein 2 (90%)"|comment:AfCS Y2H protein 58122. Translated from nucleotide sequence.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:F0VCeE8RmWjHjgm8TR6EQ1iaSwQ10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:BA1007E5E1537AEA|rigid:ZtXd7cPNXoTd/cctnARcSfwUiXQ	false	sufficient binding region:931-1286	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70172	uniprotkb:O70172	intact:EBI-644828|ensembl:ENSMUSP00000006912	intact:EBI-644828|ensembl:ENSMUSP00000006912	psi-mi:pi42a_mouse(display_long)|uniprotkb:"PtdIns(5)P-4-kinase isoform 2-alpha"(gene name synonym)|uniprotkb:Diphosphoinositide kinase 2-alpha(gene name synonym)|uniprotkb:Pip4k2a(gene name)|psi-mi:Pip4k2a(display_short)|uniprotkb:Pip5k2a(gene name synonym)|uniprotkb:1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-Phosphate 4-Kinase(gene name synonym)|uniprotkb:Pi5p4ka(gene name synonym)	psi-mi:pi42a_mouse(display_long)|uniprotkb:"PtdIns(5)P-4-kinase isoform 2-alpha"(gene name synonym)|uniprotkb:Diphosphoinositide kinase 2-alpha(gene name synonym)|uniprotkb:Pip4k2a(gene name)|psi-mi:Pip4k2a(display_short)|uniprotkb:Pip5k2a(gene name synonym)|uniprotkb:1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-Phosphate 4-Kinase(gene name synonym)|uniprotkb:Pi5p4ka(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653282	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032871.3|ensembl:ENSMUSG00000026737(gene)|ensembl:ENSMUST00000006912(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0090119"(vesicle-mediated cholesterol transport)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:O70172|reactome:R-MMU-1660499|reactome:R-MMU-6811555|reactome:R-MMU-6811558|reactome:R-MMU-8847453|dip:DIP-49438N	refseq:NP_032871.3|ensembl:ENSMUSG00000026737(gene)|ensembl:ENSMUST00000006912(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0090119"(vesicle-mediated cholesterol transport)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:O70172|reactome:R-MMU-1660499|reactome:R-MMU-6811555|reactome:R-MMU-6811558|reactome:R-MMU-8847453|dip:DIP-49438N	afcs:15014(primary-reference)|afcs:15014(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:tnXc4oMaOV1P8hQRrM6/4G5CPOQ10090	rogid:tnXc4oMaOV1P8hQRrM6/4G5CPOQ10090	intact-crc:9531EA02900528B8|rigid:l3Nyz9acNTs+N9pQPWuKPN+x6lw	false	sufficient binding region:32-307	sufficient binding region:300-405	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TSC1	uniprotkb:Q8CBW3	intact:EBI-645425|uniprotkb:Q923A9|uniprotkb:Q9Z1R1|ensembl:ENSMUSP00000025253	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:prc2a_mouse(display_long)|uniprotkb:HLA-B-associated transcript 2(gene name synonym)|uniprotkb:Prrc2a(gene name)|psi-mi:Prrc2a(display_short)|uniprotkb:Bat2(gene name synonym)|uniprotkb:Proline-rich and coiled-coil-containing protein 2A(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654421	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185973.1|refseq:NP_064411.2|refseq:XP_006524683.1|dip:DIP-49629N|ensembl:ENSMUSG00000024393(gene)|ensembl:ENSMUST00000025253(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030154"(cell differentiation)|interpro:IPR009738(BAT2, N-terminal)|interpro:IPR033184|mint:Q7TSC1	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:18449(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ktwyGkClOoaD4rZap/xJb/aKj4s10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:1376DA50966074AF|rigid:QsVXv7PdmvS6KAKSrgZ5O9refHQ	false	sufficient binding region:698-986	sufficient binding region:402-480	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JM52-2	uniprotkb:Q8CBW3	intact:EBI-645460|ensembl:ENSMUSP00000099618	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:q9jm52-2(display_long)|uniprotkb:MiNK-1(isoform synonym)|uniprotkb:Mink1(gene name)|psi-mi:Mink1(display_short)|uniprotkb:Map4k6(gene name synonym)|uniprotkb:Mink(gene name synonym)|uniprotkb:GCK family kinase MiNK(gene name synonym)|uniprotkb:MAPK/ERK kinase kinase kinase 6(gene name synonym)|uniprotkb:Misshapen/NIK-related kinase(gene name synonym)|uniprotkb:Mitogen-activated protein kinase kinase kinase kinase 6(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654432	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645434(mink1_mouse)|ensembl:ENSMUSG00000020827(gene)|ensembl:ENSMUST00000102558(transcript)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:18704(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rnwncuLeBoCPO5svI8OCN3oACVg10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:C6ADDE6904D4643F|rigid:91ZRK6AViMraiiKaHPGjVKGztNk	false	sufficient binding region:456-683	sufficient binding region:402-480	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:B9EKI5	uniprotkb:Q8CBW3	intact:EBI-682463|ensembl:ENSMUSP00000110115|ensembl:ENSMUSP00000154583	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:b9eki5_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688400	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028410.1|refseq:XP_006522014.1|ensembl:ENSMUSG00000022637(gene)|ensembl:ENSMUST00000114471(transcript)|ensembl:ENSMUST00000227062(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023051"(regulation of signaling)|go:"GO:0047690"(aspartyltransferase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:20358(primary-reference)|afcs:20358(secondary-ac)	comment:"AfCS Y2H protein 20358. Sequence deduced from cross-reference: protein GI: 20894431, replaced by protein GI: 51769670."|comment:"similat to rat Casitas B-lineage lymphoma b; Cbl-b protein (98%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/a/ZrHmGa1+dJMyubsxdzGfCrdQ10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:9FF2DE6B2FC7A73F|rigid:LOdQjyvxKPrSouZa7jBgOhFrGMY	false	sufficient binding region:266-411	sufficient binding region:403-481	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49070	uniprotkb:P11798-2	intact:EBI-309114|uniprotkb:Q99JU5|ensembl:ENSMUSP00000021963	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:camlg_mouse(display_long)|uniprotkb:Camlg(gene name)|psi-mi:Camlg(display_short)|uniprotkb:Caml(gene name synonym)|uniprotkb:Calcium signal-modulating cyclophilin ligand(gene name synonym)|uniprotkb:Get2(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653091	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031622.2|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043529"(GET complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|interpro:IPR016719(Calcium signal-modulating cyclophilin ligand)|mint:P49070|ensembl:ENSMUSG00000021501(gene)|ensembl:ENSMUST00000021963(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001881"(receptor recycling)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:13971(secondary-ac)	-	isoform-comment:Has no kinase activity.	caution:The prey construct contains 6 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:WhoJPAp432WGS6e6/wAiilnkJPM10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:81BE33FCB603AD03|rigid:DLMtA8qFMgOplGyZag+hI1Ymvuc	false	sufficient binding region:1-149	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99JZ7	uniprotkb:Q60631	intact:EBI-643375|ensembl:ENSMUSP00000073285|ensembl:ENSMUSP00000030811	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:errfi_mouse(display_long)|uniprotkb:Mitogen-inducible gene 6 protein homolog(gene name synonym)|uniprotkb:Errfi1(gene name)|psi-mi:Errfi1(display_short)|uniprotkb:Mig6(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653152	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598514.1|refseq:XP_006539273.1|ensembl:ENSMUSG00000028967(gene)|ensembl:ENSMUST00000030811(transcript)|ensembl:ENSMUST00000073600(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060426"(lung vasculature development)|go:"GO:0060428"(lung epithelium development)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR015116(GTPase binding)|interpro:IPR021619	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:34646(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:flZOynxPIeNiLKGeuDeo6JXWdgw10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:E16C26A860DCD8A5|rigid:2cUgsEZtkBivgkb1Rz95wOQcBKY	false	sufficient binding region:159-417	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99JZ7	uniprotkb:Q60631	intact:EBI-643375|ensembl:ENSMUSP00000073285|ensembl:ENSMUSP00000030811	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:errfi_mouse(display_long)|uniprotkb:Mitogen-inducible gene 6 protein homolog(gene name synonym)|uniprotkb:Errfi1(gene name)|psi-mi:Errfi1(display_short)|uniprotkb:Mig6(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653162	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598514.1|refseq:XP_006539273.1|ensembl:ENSMUSG00000028967(gene)|ensembl:ENSMUST00000030811(transcript)|ensembl:ENSMUST00000073600(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060426"(lung vasculature development)|go:"GO:0060428"(lung epithelium development)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR015116(GTPase binding)|interpro:IPR021619	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:34646(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:flZOynxPIeNiLKGeuDeo6JXWdgw10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:A55EA3ACA024CFB9|rigid:2cUgsEZtkBivgkb1Rz95wOQcBKY	false	sufficient binding region:166-329	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02384	uniprotkb:Q60631	intact:EBI-395573|ensembl:ENSMUSP00000138793	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:sos2_mouse(display_long)|uniprotkb:Sos2(gene name)|psi-mi:Sos2(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653242	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034801(gene)|ensembl:ENSMUST00000183277(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|rcsb pdb:1GBR|reactome:R-MMU-416482|reactome:R-MMU-193648|refseq:XP_006515698.1|reactome:R-MMU-8983432|reactome:R-MMU-9013149	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:33836(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:s2OD+2IxmqGbJeKCshNho0MJczM10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:AD648C38A0B0DB2A|rigid:EzXl9RSWNqHJflfY/7eI1Sh5odU	false	sufficient binding region:1056-1220	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z179	uniprotkb:P98083	intact:EBI-644352|uniprotkb:Q3UED9|uniprotkb:Q3UMD9|ensembl:ENSMUSP00000022945	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:shcbp_mouse(display_long)|uniprotkb:Protein expressed in activated lymphocytes(gene name synonym)|uniprotkb:SHC-binding protein(gene name synonym)|uniprotkb:Shcbp1(gene name)|psi-mi:Shcbp1(display_short)|uniprotkb:Pal(gene name synonym)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652075	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035499.1|ensembl:ENSMUSG00000022322(gene)|ensembl:ENSMUST00000022945(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0042169"(SH2 domain binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR039448	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:16731(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MgcPGnEzLfUPCtS+m+6NJ4Yyr2k10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:80343C1066317E36|rigid:J4QPdBrChXQdBwLoyulvqNyg/do	false	sufficient binding region:6-260	sufficient binding region:476-577	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99K43	uniprotkb:P97797-2	intact:EBI-644779|uniprotkb:E9QPF0|uniprotkb:Q8CE25|ensembl:ENSMUSP00000043379	intact:EBI-644767|ensembl:ENSMUSP00000099491|ensembl:ENSMUSP00000099492|ensembl:ENSMUSP00000137611	psi-mi:prc1_mouse(display_long)|uniprotkb:Prc1(gene name)|psi-mi:Prc1(display_short)	psi-mi:p97797-2(display_long)|uniprotkb:a'(isoform synonym)|uniprotkb:Large(isoform synonym)|uniprotkb:Sirpa(gene name)|psi-mi:Sirpa(display_short)|uniprotkb:Bit(gene name synonym)|uniprotkb:Myd1(gene name synonym)|uniprotkb:Ptpns1(gene name synonym)|uniprotkb:Shps1(gene name synonym)|uniprotkb:Sirp(gene name synonym)|uniprotkb:Brain Ig-like molecule with tyrosine-based activation motifs(gene name synonym)|uniprotkb:CD172 antigen-like family member A(gene name synonym)|uniprotkb:Inhibitory receptor SHPS-1(gene name synonym)|uniprotkb:MyD-1 antigen(gene name synonym)|uniprotkb:Signal-regulatory protein alpha-1(gene name synonym)|uniprotkb:p84(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652955	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272926.1|reactome:R-MMU-5625900|interpro:IPR032921|ensembl:ENSMUSG00000038943(gene)|ensembl:ENSMUST00000047558(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0070938"(contractile ring)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR007145(MAP65/ASE1)	intact:EBI-644732(shps1_mouse)|ensembl:ENSMUSG00000037902(gene)|ensembl:ENSMUST00000103202(transcript)|ensembl:ENSMUST00000103203(transcript)|ensembl:ENSMUST00000179001(transcript)	afcs:13927(primary-reference)|afcs:40037(secondary-ac)	-	-	caution:The prey construct contains 21 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2019/05/28	rogid:Xu052dxwVt00LivzQdjuZFKxtEc10090	rogid:BizOlzcxt/ZnyXOwyjZZRqYkpd810090	intact-crc:06C7335A9C7787A0|rigid:GlaPzpVn6MEN40xRn2g66xHMU7s	false	sufficient binding region:1-113	sufficient binding region:395-509	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6NZN1	uniprotkb:Q9QYY0	intact:EBI-644797|uniprotkb:Q3UGG3|uniprotkb:Q80TW6|uniprotkb:Q8BXP6|uniprotkb:Q91YW8|ensembl:ENSMUSP00000107530	intact:EBI-644784|uniprotkb:Q91VW7|ensembl:ENSMUSP00000034150	psi-mi:pprc1_mouse(display_long)|uniprotkb:PGC-1-related coactivator(gene name synonym)|uniprotkb:Pprc1(gene name)|psi-mi:Pprc1(display_short)|uniprotkb:Kiaa0595(gene name synonym)	psi-mi:gab1_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:Gab1(gene name)|psi-mi:Gab1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652966	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074683.1|ensembl:ENSMUST00000111899(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034597|interpro:IPR034605|interpro:IPR034834|interpro:IPR035979|ensembl:ENSMUSG00000055491(gene)|refseq:NP_001333730.1|refseq:XP_017173655.1	refseq:NP_067331.2|ensembl:ENSMUSG00000031714(gene)|ensembl:ENSMUST00000034150(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q9QYY0|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-180292|reactome:R-MMU-1963642|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027276|dip:DIP-39377N	afcs:23867(primary-reference)|afcs:21362(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:wbe4I3sDNj5uVIWbwhxCVkrQkWg10090	rogid:SVtcnzm9XpYftTZ3qAV/IQgJaJE10090	intact-crc:F3268E0A0041EA3E|rigid:zB6nWOT0UzdgcWh70ipc7um3fHU	false	sufficient binding region:?-?	sufficient binding region:1-120	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R269	uniprotkb:P31750	intact:EBI-368293|uniprotkb:O70231|uniprotkb:Q9CUT1|uniprotkb:Q9JLZ7	intact:EBI-298707|ensembl:ENSMUSP00000001780|uniprotkb:Q62274|uniprotkb:Q6GSA6	psi-mi:pepl_mouse(display_long)|uniprotkb:Ppl(gene name)|psi-mi:Ppl(display_short)	psi-mi:akt1_mouse(display_long)|uniprotkb:Akt1(gene name)|psi-mi:Akt1(display_short)|uniprotkb:Akt(gene name synonym)|uniprotkb:Rac(gene name synonym)|uniprotkb:RAC-PK-alpha(gene name synonym)|uniprotkb:AKT1 kinase(gene name synonym)|uniprotkb:Proto-oncogene c-Akt(gene name synonym)|uniprotkb:Protein kinase B(gene name synonym)|uniprotkb:Thymoma viral proto-oncogene(gene name synonym)|uniprotkb:Protein kinase B alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652998	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	mint:Q9R269|interpro:IPR001452(Src homology-3)|refseq:NP_032935.2|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030057"(desmosome)|go:"GO:0031424"(keratinization)|go:"GO:0042060"(wound healing)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|interpro:IPR035915|interpro:IPR041615|interpro:IPR043197	go:"GO:0097194"(execution phase of apoptosis)|go:"GO:0099104"(potassium channel activator activity)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110099"(negative regulation of calcium import into the mitochondrion)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1903038"(negative regulation of leukocyte cell-cell adhesion)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:1990418"(response to insulin-like growth factor stimulus)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034676|interpro:IPR039026|interpro:IPR039027|mint:P31750|reactome:R-MMU-1257604|reactome:R-MMU-1358803|reactome:R-MMU-1474151|reactome:R-MMU-165159|reactome:R-MMU-198323|reactome:R-MMU-198693|reactome:R-MMU-199418|reactome:R-MMU-203615|reactome:R-MMU-211163|reactome:R-MMU-354192|reactome:R-MMU-3769402|reactome:R-MMU-389357|reactome:R-MMU-389513|reactome:R-MMU-392451|reactome:R-MMU-450385|reactome:R-MMU-450604|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-6811558|reactome:R-MMU-69202|reactome:R-MMU-69656|reactome:R-MMU-8849469|reactome:R-MMU-8876198|reactome:R-MMU-8948751|reactome:R-MMU-9009391|reactome:R-MMU-9604323|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9634638|ensembl:ENSMUSG00000001729(gene)|ensembl:ENSMUST00000001780(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0005979"(regulation of glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0006954"(inflammatory response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008637"(apoptotic mitochondrial changes)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009725"(response to hormone)|go:"GO:0010033"(response to organic substance)|go:"GO:0010467"(gene expression)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0010951"(negative regulation of endopeptidase activity)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016301"(kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0030030"(cell projection organization)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030212"(hyaluronan metabolic process)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0031999"(negative regulation of fatty acid beta-oxidation)|go:"GO:0032079"(positive regulation of endodeoxyribonuclease activity)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032094"(response to food)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032929"(negative regulation of superoxide anion generation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034405"(response to fluid shear stress)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035655"(interleukin-18-mediated signaling pathway)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036064"(ciliary basal body)|go:"GO:0036294"(cellular response to decreased oxygen levels)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0046622"(positive regulation of organ growth)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0060709"(glycogen cell differentiation involved in embryonic placenta development)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0070141"(response to UV-A)|go:"GO:0070848"(response to growth factor)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071380"(cellular response to prostaglandin E stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072655"(establishment of protein localization to mitochondrion)|go:"GO:0072656"(maintenance of protein location in mitochondrion)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|refseq:NP_001159366.1|refseq:NP_033782.1|refseq:XP_006515478.1|refseq:NP_001318036.1|dip:DIP-736N	afcs:15657(primary-reference)|afcs:24074(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uyY/30fV0RHik6nx6lkWxKr5Diw10090	rogid:qZx+MZ1X4i0lL1kvsVCsxJONKQ410090	intact-crc:DAF895CE75B4E81E|rigid:I6cjyWtqgVIyiB9FtmtlCSC526U	false	sufficient binding region:1592-1755	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654985	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:3D08F9DB4E3F0EBF|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:269-552	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655006	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:C3E249DB5B9FA409|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:290-611	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655016	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:2A8DCC83236FB19C|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:291-556	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655026	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:031885021F3AA667|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:293-611	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655036	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:BFA71FE79A577E41|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:311-611	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655056	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:C64D2C69C495D2A6|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:363-609	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655066	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:3B3FFB5D26ADCCD3|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:375-611	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655086	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:73AAF8AE11A49F03|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:394-611	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655199	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:10BDD3FB3C3FAFFB|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:535-727	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655209	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:968B80AFE2EC8864|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:277-438	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655220	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:9F5B4451338DA7FF|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:362-527	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655240	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:5E783B456D2E786B|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:428-581	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655260	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:476249DE01977449|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:524-671	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655270	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:4296C9D79121B569|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:532-727	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655290	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:AECB8D0B9C381EF1|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:536-713	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BYZ7	uniprotkb:Q8BUR4	intact:EBI-646035|uniprotkb:Q6PDE4|ensembl:ENSMUSP00000105000	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:elmo3_mouse(display_long)|uniprotkb:Elmo3(gene name)|psi-mi:Elmo3(display_short)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655330	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766348.3|ensembl:ENSMUSG00000014791(gene)|ensembl:ENSMUST00000109375(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0048870"(cell motility)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030719	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:40199(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:J1VuWFosyLfFwcOdpjtSFgGvRHM10090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:1AF6DA9E0F4A0A4D|rigid:UwROjZKhH/ywr/aSgpUy+zghg3I	false	sufficient binding region:493-704	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C0C0	uniprotkb:Q8BUR4	intact:EBI-646042|ensembl:ENSMUSP00000094164	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:zhx2_mouse(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:Zhx2(gene name)|psi-mi:Zhx2(display_short)|uniprotkb:Afr1(gene name synonym)|uniprotkb:Raf(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655340	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_955520.1|refseq:XP_011243990.1|refseq:XP_011243991.1|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|mint:Q8C0C0|ensembl:ENSMUSG00000071757(gene)|ensembl:ENSMUST00000096430(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:54993(secondary-ac)	-	-	caution:The prey construct contains 24 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:CfLzg3RnMJLrG5O8s42wXRyNhLk10090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:2DBF19BF1CBEC013|rigid:wnkoaeSboqFLnLZD7cRWk5tHjEI	false	sufficient binding region:1-248	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C0C0	uniprotkb:Q8BUR4	intact:EBI-646042|ensembl:ENSMUSP00000094164	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:zhx2_mouse(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:Zhx2(gene name)|psi-mi:Zhx2(display_short)|uniprotkb:Afr1(gene name synonym)|uniprotkb:Raf(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655350	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_955520.1|refseq:XP_011243990.1|refseq:XP_011243991.1|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|mint:Q8C0C0|ensembl:ENSMUSG00000071757(gene)|ensembl:ENSMUST00000096430(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:54993(secondary-ac)	-	-	caution:The prey construct contains 7 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:CfLzg3RnMJLrG5O8s42wXRyNhLk10090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:8F7BDB2133668220|rigid:wnkoaeSboqFLnLZD7cRWk5tHjEI	false	sufficient binding region:1-331	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C0C0	uniprotkb:Q8BUR4	intact:EBI-646042|ensembl:ENSMUSP00000094164	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:zhx2_mouse(display_long)|uniprotkb:Zinc finger and homeodomain protein 2(gene name synonym)|uniprotkb:Alpha-fetoprotein regulator 1(gene name synonym)|uniprotkb:Regulator of AFP(gene name synonym)|uniprotkb:Zhx2(gene name)|psi-mi:Zhx2(display_short)|uniprotkb:Afr1(gene name synonym)|uniprotkb:Raf(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655360	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_955520.1|refseq:XP_011243990.1|refseq:XP_011243991.1|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0060040"(retinal bipolar neuron differentiation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR041057|mint:Q8C0C0|ensembl:ENSMUSG00000071757(gene)|ensembl:ENSMUST00000096430(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:54993(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:CfLzg3RnMJLrG5O8s42wXRyNhLk10090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:709A4B4C2C69B4E8|rigid:wnkoaeSboqFLnLZD7cRWk5tHjEI	false	sufficient binding region:50-268	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P17809	uniprotkb:P25118	intact:EBI-646060|uniprotkb:Q6GTI3|uniprotkb:Q61608|ensembl:ENSMUSP00000030398	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:gtr1_mouse(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:Slc2a1(gene name)|psi-mi:Slc2a1(display_short)|uniprotkb:Glut1(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655380	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035530.2|ensembl:ENSMUSG00000028645(gene)|ensembl:ENSMUST00000030398(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031982"(vesicle)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070837"(dehydroascorbic acid transport)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-MMU-189200|reactome:R-MMU-196836|reactome:R-MMU-422356|reactome:R-MMU-5653890	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:12990(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:eMyuch9D1aqplNWyRMyGfWMF7WQ10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:9FC7CE179F9E8061|rigid:aV4WnXS2gXttpLVsEQGYErYkOag	false	sufficient binding region:134-459	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P17809	uniprotkb:P25118	intact:EBI-646060|uniprotkb:Q6GTI3|uniprotkb:Q61608|ensembl:ENSMUSP00000030398	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:gtr1_mouse(display_long)|uniprotkb:Glucose transporter type 1, erythrocyte/brain(gene name synonym)|uniprotkb:Slc2a1(gene name)|psi-mi:Slc2a1(display_short)|uniprotkb:Glut1(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655391	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035530.2|ensembl:ENSMUSG00000028645(gene)|ensembl:ENSMUST00000030398(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0001939"(female pronucleus)|go:"GO:0005324"(long-chain fatty acid transporter activity)|go:"GO:0005355"(glucose transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007417"(central nervous system development)|go:"GO:0007565"(female pregnancy)|go:"GO:0014704"(intercalated disc)|go:"GO:0015911"(long-chain fatty acid import across plasma membrane)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019900"(kinase binding)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0030018"(Z disc)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031982"(vesicle)|go:"GO:0032868"(response to insulin)|go:"GO:0033300"(dehydroascorbic acid transmembrane transporter activity)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0042908"(xenobiotic transport)|go:"GO:0042910"(xenobiotic transmembrane transporter activity)|go:"GO:0043621"(protein self-association)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0055056"(D-glucose transmembrane transporter activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070837"(dehydroascorbic acid transport)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0098708"(glucose import across plasma membrane)|go:"GO:0098793"(presynapse)|go:"GO:0150104"(transport across blood-brain barrier)|go:"GO:1904016"(response to Thyroglobulin triiodothyronine)|go:"GO:1904659"(glucose transmembrane transport)|interpro:IPR002439("Glucose transporter, type 1 (GLUT1)")|interpro:IPR003663(Sugar transporter)|interpro:IPR005828(General substrate transporter)|interpro:IPR005829(Sugar transporter, conserved site)|interpro:IPR020846|interpro:IPR036259|reactome:R-MMU-189200|reactome:R-MMU-196836|reactome:R-MMU-422356|reactome:R-MMU-5653890	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:12990(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:eMyuch9D1aqplNWyRMyGfWMF7WQ10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:5C84B03A9C2251B4|rigid:aV4WnXS2gXttpLVsEQGYErYkOag	false	sufficient binding region:229-449	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z148-1	uniprotkb:P25118	intact:EBI-444981|ensembl:ENSMUSP00000013931	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:q9z148-1(display_long)|uniprotkb:G9a-L(isoform synonym)|uniprotkb:Ehmt2(gene name)|psi-mi:Ehmt2(display_short)|uniprotkb:Bat8(gene name synonym)|uniprotkb:G9a(gene name synonym)|uniprotkb:Ng36(gene name synonym)|uniprotkb:Euchromatic histone-lysine N-methyltransferase 2(gene name synonym)|uniprotkb:HLA-B-associated transcript 8(gene name synonym)|uniprotkb:Histone H3-K9 methyltransferase 3(gene name synonym)|uniprotkb:Protein G9a(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655402	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-444966(ehmt2_mouse)|ensembl:ENSMUSG00000013787(gene)|ensembl:ENSMUST00000013931(transcript)	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:40192(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SN94zTs0cmZHuzgtVLjSTDtfOAM10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:8CA7D97C71847AA5|rigid:xL3Ufqb9hcn4lWuTVn64h9gUPj4	false	sufficient binding region:382-871	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P00860	uniprotkb:P25118	intact:EBI-646076|uniprotkb:Q6PB87|uniprotkb:Q61997|uniprotkb:Q61998|ensembl:ENSMUSP00000128661	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:dcor_mouse(display_long)|uniprotkb:Odc1(gene name)|psi-mi:Odc1(display_short)|uniprotkb:Odc(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655412	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038642.2|refseq:XP_017170479.1|ensembl:ENSMUSG00000011179(gene)|ensembl:ENSMUST00000171737(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0004586"(ornithine decarboxylase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006595"(polyamine metabolic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009446"(putrescine biosynthetic process)|go:"GO:0033387"(putrescine biosynthetic process from ornithine)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR000183(Orn/DAP/Arg decarboxylase 2)|interpro:IPR002433(Ornithine decarboxylase)|interpro:IPR009006(Alanine racemase/group IV decarboxylase, C-terminal)|interpro:IPR022643|interpro:IPR022644|interpro:IPR022653|interpro:IPR022657|interpro:IPR029066|rcsb pdb:7ODC|reactome:R-MMU-350562|reactome:R-MMU-351202	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:17316(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Dno6lIZPekbOXG/6GO6YvqptRC810090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:A18E40174B7A9EEE|rigid:iJ8pL8P+CGmjgkJ+oVbRgmfe0qw	false	sufficient binding region:433-461	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688030	uniprotkb:P56477	afcs:35828	intact:EBI-643408|ensembl:ENSMUSP00000004392|ensembl:ENSMUSP00000127021	psi-mi:ep300_mouse_protein(display_short)|psi-mi:EBI-688030(display_long)	psi-mi:irf5_mouse(display_long)|uniprotkb:Irf5(gene name)|psi-mi:Irf5(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688411	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_036187.1|refseq:NP_001239311.1|refseq:XP_006505160.1|ensembl:ENSMUSG00000029771(gene)|ensembl:ENSMUST00000004392(transcript)|ensembl:ENSMUST00000163511(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR029838|interpro:IPR036388|interpro:IPR036390|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|dip:DIP-49382N	afcs:35828(primary-reference)|afcs:17187(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:AfCS Y2H protein 35828. Translated from nucleotide sequence.|comment:"similar to EP300_HUMAN E1A-associated protein p300 (EC 2.3.1.48)(95%)."	-	caution:The prey construct contains 10 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:UF1glEKf3P+SmamnZPz30gYwQHM10090	rogid:Mdz1n0MUvYYjxamfbVAzdusN1M810090	intact-crc:356E618BC43754B9|rigid:B1GrvHIzGEI1A/z3TEVfCv4AKQY	false	sufficient binding region:1730-1970	sufficient binding region:1-453	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688030	uniprotkb:Q99NB9	afcs:35828	intact:EBI-688642|uniprotkb:Q9CSK5	psi-mi:ep300_mouse_protein(display_short)|psi-mi:EBI-688030(display_long)	psi-mi:sf3b1_mouse(display_long)|uniprotkb:Pre-mRNA-splicing factor SF3b 155 kDa subunit(gene name synonym)|uniprotkb:Spliceosome-associated protein 155(gene name synonym)|uniprotkb:Sf3b1(gene name)|psi-mi:Sf3b1(display_short)|uniprotkb:Sap155(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688651	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR015016(Splicing factor 3B subunit 1)|interpro:IPR038737|mint:Q99NB9|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0000785"(chromatin)|go:"GO:0001825"(blastocyst formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005686"(U2 snRNP)|go:"GO:0005689"(U12-type spliceosomal complex)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0030532"(small nuclear ribonucleoprotein complex)|go:"GO:0034693"(U11/U12 snRNP)|go:"GO:0071004"(U2-type prespliceosome)|go:"GO:0071005"(U2-type precatalytic spliceosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:1990935"(splicing factor binding)|reactome:R-MMU-5250924|reactome:R-MMU-72163|reactome:R-MMU-72165	afcs:35828(primary-reference)|afcs:40178(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:AfCS Y2H protein 35828. Translated from nucleotide sequence.|comment:"similar to EP300_HUMAN E1A-associated protein p300 (EC 2.3.1.48)(95%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:UF1glEKf3P+SmamnZPz30gYwQHM10090	rogid:NPPPnKP4RuT43H/9MKMGIkQqZTM10090	intact-crc:1E63854316768867|rigid:ptumvvNEpqumj4E/YPCpgoygUSo	false	sufficient binding region:1730-1970	sufficient binding region:644-905	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q99LE1	afcs:35826	intact:EBI-688699|uniprotkb:Q3TB73|ensembl:ENSMUSP00000031347	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:ripl2_mouse(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 2(gene name synonym)|uniprotkb:Rilpl2(gene name)|psi-mi:Rilpl2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688757	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_084535.1|ensembl:ENSMUSG00000029401(gene)|ensembl:ENSMUST00000031347(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:4KP3	afcs:35826(primary-reference)|afcs:30168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:BiK3OWBdnz/agb+8dWxuQdXTaFE10090	intact-crc:72961235117A66C4|rigid:2l6ECc8b7mK4/Wab78X8vyYMUmI	false	sufficient binding region:248-450	sufficient binding region:1-146	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q99LE1	afcs:35826	intact:EBI-688699|uniprotkb:Q3TB73|ensembl:ENSMUSP00000031347	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:ripl2_mouse(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 2(gene name synonym)|uniprotkb:Rilpl2(gene name)|psi-mi:Rilpl2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688768	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_084535.1|ensembl:ENSMUSG00000029401(gene)|ensembl:ENSMUST00000031347(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:4KP3	afcs:35826(primary-reference)|afcs:30168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:BiK3OWBdnz/agb+8dWxuQdXTaFE10090	intact-crc:862605FC3C81FED8|rigid:2l6ECc8b7mK4/Wab78X8vyYMUmI	false	sufficient binding region:248-450	sufficient binding region:1-155	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q99LE1	afcs:35826	intact:EBI-688699|uniprotkb:Q3TB73|ensembl:ENSMUSP00000031347	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:ripl2_mouse(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 2(gene name synonym)|uniprotkb:Rilpl2(gene name)|psi-mi:Rilpl2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688779	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_084535.1|ensembl:ENSMUSG00000029401(gene)|ensembl:ENSMUST00000031347(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:4KP3	afcs:35826(primary-reference)|afcs:30168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:BiK3OWBdnz/agb+8dWxuQdXTaFE10090	intact-crc:C432494DFB0E6A97|rigid:2l6ECc8b7mK4/Wab78X8vyYMUmI	false	sufficient binding region:248-450	sufficient binding region:12-169	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99LE1	intact:EBI-688018	intact:EBI-688699|uniprotkb:Q3TB73|ensembl:ENSMUSP00000031347	afcs:35826	psi-mi:ripl2_mouse(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 2(gene name synonym)|uniprotkb:Rilpl2(gene name)|psi-mi:Rilpl2(display_short)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688790	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_084535.1|ensembl:ENSMUSG00000029401(gene)|ensembl:ENSMUST00000031347(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:4KP3	-	afcs:35826(primary-reference)|afcs:30168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BiK3OWBdnz/agb+8dWxuQdXTaFE10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:9980E9D6497CC652|rigid:2l6ECc8b7mK4/Wab78X8vyYMUmI	false	sufficient binding region:51-197	sufficient binding region:248-450	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q9D0I9	afcs:35826	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688941	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	caution:The prey construct contains 4 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	intact-crc:C2FD9A1142C73D5E|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:248-450	sufficient binding region:1-144	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0I9	intact:EBI-688018	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	afcs:35826	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688990	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	-	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	caution:The prey construct contains 3 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:746BC34EC33D5D87|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:1-317	sufficient binding region:248-450	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q9D0I9	afcs:35826	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-689002	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	caution:The prey construct contains 2 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	intact-crc:33869DE094825F97|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:248-450	sufficient binding region:1-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q9D0I9	afcs:35826	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-689037	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	intact-crc:E2484F4610D9E96C|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:248-450	sufficient binding region:2-334	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q9D0I9	afcs:35826	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-689048	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	intact-crc:C16203A7AD8C186D|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:248-450	sufficient binding region:18-229	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JLQ2	uniprotkb:Q9ES28	intact:EBI-642860|uniprotkb:E9QPU7|ensembl:ENSMUSP00000107803	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:git2_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 2(gene name synonym)|uniprotkb:GRK-interacting protein 2(gene name synonym)|uniprotkb:Cool-interacting tyrosine-phosphorylated protein 2(gene name synonym)|uniprotkb:Git2(gene name)|psi-mi:Git2(display_short)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650287	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062808.3|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q9JLQ2|rcsb pdb:6JMT|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|ensembl:ENSMUSG00000041890(gene)|ensembl:ENSMUST00000112185(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	afcs:17882(primary-reference)|afcs:18337(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mOkKto/u8bzW0feEp3Kah7fYeOI10090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	intact-crc:76F5F5651AF445C0|rigid:Gf/L0bks/IehTveMU+ldy5LxVDw	false	sufficient binding region:1-397	sufficient binding region:300-581	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61210-2	uniprotkb:Q61210	intact:EBI-641840|ensembl:ENSMUSP00000146314	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:q61210-2(display_long)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650378	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-641821(arhg1_mouse)|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000206508(transcript)	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:14722(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:632ezxE2++lu0/EFRBU1b/ofnF410090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:3FA34C643D20887F|rigid:M1DG10ni8KxUe711dg3eV7n1kCA	false	sufficient binding region:155-361	sufficient binding region:1-200	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61210-2	uniprotkb:Q61210	intact:EBI-641840|ensembl:ENSMUSP00000146314	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:q61210-2(display_long)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650389	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-641821(arhg1_mouse)|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000206508(transcript)	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:14722(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:632ezxE2++lu0/EFRBU1b/ofnF410090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:FA048C6EAA1A127C|rigid:M1DG10ni8KxUe711dg3eV7n1kCA	false	sufficient binding region:165-583	sufficient binding region:1-200	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TNC4	uniprotkb:E9PZQ0	intact:EBI-643009|uniprotkb:Q99LM5|uniprotkb:Q99PC3|ensembl:ENSMUSP00000055254	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:lc7l2_mouse(display_long)|uniprotkb:CGI-74 homolog(gene name synonym)|uniprotkb:Luc7l2(gene name)|psi-mi:Luc7l2(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650540	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001164320.1|refseq:NP_619621.2|ensembl:ENSMUSG00000029823(gene)|ensembl:ENSMUST00000057692(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)|mint:Q7TNC4	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34661(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4x7JD0FyuuhCrHahqU96S6UyD1o10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:424DACD092879B92|rigid:CpozIbClrdiBsFP7+yYutUMK5j8	false	sufficient binding region:157-268	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JMH9	uniprotkb:Q61210	intact:EBI-643214|uniprotkb:Q3TBB2|uniprotkb:Q3UH48|uniprotkb:Q3UV60|uniprotkb:Q5SYN8|uniprotkb:Q5SYN9|uniprotkb:Q5SYP0|uniprotkb:Q5SYP1|uniprotkb:Q811D7|ensembl:ENSMUSP00000104012|uniprotkb:Q5QD54|uniprotkb:Q5QD55|uniprotkb:Q5QD56	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:my18a_mouse(display_long)|uniprotkb:Myosin containing a PDZ domain(gene name synonym)|uniprotkb:Molecule associated with JAK3 N-terminus(gene name synonym)|uniprotkb:Myo18a(gene name)|psi-mi:Myo18a(display_short)|uniprotkb:Myspdz(gene name synonym)|uniprotkb:Surfactant protein receptor SP-R210(gene name synonym)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650723	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035716.1|refseq:XP_006533667.1|refseq:XP_006533669.1|refseq:XP_006533677.2|refseq:NP_001278141.1|refseq:NP_001278142.1|refseq:NP_001278143.1|refseq:NP_001278144.1|go:"GO:0005903"(brush border)|go:"GO:0007030"(Golgi organization)|go:"GO:0016459"(myosin complex)|go:"GO:0016477"(cell migration)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042641"(actomyosin)|go:"GO:0043030"(regulation of macrophage activation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043531"(ADP binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048194"(Golgi vesicle budding)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051015"(actin filament binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090161"(Golgi ribbon formation)|go:"GO:0090164"(asymmetric Golgi ribbon formation)|go:"GO:1903028"(positive regulation of opsonization)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001609(Myosin head, motor region)|interpro:IPR002928(Myosin tail)|interpro:IPR004009(Myosin, N-terminal, SH3-like)|interpro:IPR027417|interpro:IPR031244|interpro:IPR036034|interpro:IPR036064|interpro:IPR036961|mint:Q9JMH9|ensembl:ENSMUSG00000000631(gene)|ensembl:ENSMUST00000108375(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005524"(ATP binding)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005856"(cytoskeleton)|refseq:XP_017170115.1	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:34666(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TZQzZ2x1aphZBaHL6GPOTcdJzco10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:5761694A30D711D4|rigid:VeVfiC//Nt08fmKjfpd4ljCUpa0	false	sufficient binding region:1463-1746	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q920Q8	uniprotkb:Q61210	intact:EBI-643239|uniprotkb:Q06BK6|uniprotkb:Q3TXI1|uniprotkb:Q3UJE3|uniprotkb:Q3UJS1|uniprotkb:Q3UKH9|uniprotkb:Q3UMK9|uniprotkb:Q6ZQ34|uniprotkb:Q99KN0|uniprotkb:Q9D978|ensembl:ENSMUSP00000023918	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:ns1bp_mouse(display_long)|uniprotkb:Kelch family protein Nd1-L(gene name synonym)|uniprotkb:ND1-L2(gene name synonym)|uniprotkb:Nd1-S(gene name synonym)|uniprotkb:Ivns1abp(gene name)|psi-mi:Ivns1abp(display_short)|uniprotkb:Kiaa0850(gene name synonym)|uniprotkb:Nd1(gene name synonym)|uniprotkb:Nd1L(gene name synonym)|uniprotkb:Nd1S(gene name synonym)|uniprotkb:Ns1(gene name synonym)|uniprotkb:Ns1bp(gene name synonym)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650733	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001034600.1|refseq:NP_001034601.1|refseq:NP_473443.2|ensembl:ENSMUSG00000023150(gene)|ensembl:ENSMUST00000023918(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008380"(RNA splicing)|go:"GO:0009615"(response to virus)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:2001243"(negative regulation of intrinsic apoptotic signaling pathway)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR011705(BTB/Kelch-associated)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:34649(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:j5/XawL9H4va/BB/HXbIeItP7MY10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:56F34CCB7D2447ED|rigid:Pj8Uu6livB985wQ0AAzyz+WlG1s	false	sufficient binding region:105-462	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QXZ0	uniprotkb:Q61210	intact:EBI-643248|intact:EBI-2658096|uniprotkb:B1ARU3|uniprotkb:Q4PLL5|uniprotkb:P97394|uniprotkb:P97395|uniprotkb:P97396	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:macf1_mouse(display_long)|uniprotkb:Actin cross-linking family 7(gene name synonym)|uniprotkb:Macf1(gene name)|psi-mi:Macf1(display_short)|uniprotkb:Acf7(gene name synonym)|uniprotkb:Aclp7(gene name synonym)|uniprotkb:Macf(gene name synonym)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650743	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR002017(Spectrin repeat)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003108(Growth-arrest-specific protein 2)|interpro:IPR001101(Plectin repeat)|interpro:IPR018159|interpro:IPR001452(Src homology-3)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032587"(ruffle membrane)|go:"GO:0006620"(posttranslational protein targeting to endoplasmic reticulum membrane)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0008017"(microtubule binding)|go:"GO:0032886"(regulation of microtubule-based process)|go:"GO:0042060"(wound healing)|go:"GO:0008104"(protein localization)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:0150011"(regulation of neuron projection arborization)|mint:Q9QXZ0|interpro:IPR035915|interpro:IPR036534|interpro:IPR036872|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:34664(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:niJxpkI45VTa5x73A1tuX/aLXgo10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:D5FE5838FEC48DC7|rigid:t7g31pfj5KeNfhSU0IkS8ZW7SRc	false	sufficient binding region:964-1093	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R2M7	uniprotkb:E9PZQ0	intact:EBI-643304	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:q8r2m7_mouse(display_long)|uniprotkb:Zfp472(gene name)|psi-mi:Zfp472(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650753	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR036051|interpro:IPR036236	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34663(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YQ0NdgPtRPwpb2a0pQZ/v+vcbWE10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:DCD12E54723AB0C2|rigid:JVBn4Ehl0aT1cEjvNeBkFDPa/8Q	false	sufficient binding region:43-452	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O55108	uniprotkb:E9PZQ0	intact:EBI-643315	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:o55108_mouse(display_long)|uniprotkb:Bsg(gene name)|psi-mi:Bsg(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650773	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005537"(mannose binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34643(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:99x0BoyhEaFoUtTrud/7CV0STYg10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:4DEC0454D14CCD3B|rigid:wXBdjOi7vfF1uLDsJgUTMAFO6Wg	false	sufficient binding region:64-253	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JJA2	uniprotkb:Q99N72	intact:EBI-643333|uniprotkb:Q8BFW5|ensembl:ENSMUSP00000034391|ensembl:ENSMUSP00000093173	intact:EBI-641874	psi-mi:cog8_mouse(display_long)|uniprotkb:Component of oligomeric Golgi complex 8(gene name synonym)|uniprotkb:Cog8(gene name)|psi-mi:Cog8(display_short)|uniprotkb:MNCb-5704(orf name)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650802	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_631975.3|ensembl:ENSMUSG00000031916(gene)|ensembl:ENSMUST00000034391(transcript)|ensembl:ENSMUST00000095517(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0015031"(protein transport)|go:"GO:0017119"(Golgi transport complex)|interpro:IPR007255(Dor1-like protein)|interpro:IPR016159(Cullin repeat-like)|interpro:IPR016632(Conserved oligomeric Golgi complex, COG8)|reactome:R-MMU-6807878|reactome:R-MMU-6811438|reactome:R-MMU-6811440	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:34659(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:F4wXkjcUbI6CQNqhATh/5aH59Uo10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:E16BACC5435F8B46|rigid:0TpF6YJSNbIoMzJSX3gtQ4ai7Ek	false	sufficient binding region:3-424	sufficient binding region:325-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BL48	uniprotkb:Q61210	intact:EBI-643350|uniprotkb:Q8BVI6|uniprotkb:Q99JZ8|uniprotkb:Q99LL9|uniprotkb:A2A853|ensembl:ENSMUSP00000021116	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:unk_mouse(display_long)|uniprotkb:Zinc finger CCCH domain-containing protein 5(gene name synonym)|uniprotkb:Unk(gene name)|psi-mi:Unk(display_short)|uniprotkb:Kiaa1753(gene name synonym)|uniprotkb:Zc3hdc5(gene name synonym)|uniprotkb:Zc3h5(gene name synonym)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650832	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766157.1|ensembl:ENSMUSG00000020770(gene)|ensembl:ENSMUST00000021116(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:1905538"(polysome binding)|go:"GO:1990715"(mRNA CDS binding)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR036855|interpro:IPR040594|mint:Q8BL48|rcsb pdb:5ELH|rcsb pdb:5ELK	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:34652(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+7BVlzD+jczZ9/NZxDyCx1ZpGpU10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:DE6D309507B36B1C|rigid:XswE9oTSUDMAcTt/YEgWTcgSASU	false	sufficient binding region:583-711	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BL48	uniprotkb:Q61210	intact:EBI-643350|uniprotkb:Q8BVI6|uniprotkb:Q99JZ8|uniprotkb:Q99LL9|uniprotkb:A2A853|ensembl:ENSMUSP00000021116	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:unk_mouse(display_long)|uniprotkb:Zinc finger CCCH domain-containing protein 5(gene name synonym)|uniprotkb:Unk(gene name)|psi-mi:Unk(display_short)|uniprotkb:Kiaa1753(gene name synonym)|uniprotkb:Zc3hdc5(gene name synonym)|uniprotkb:Zc3h5(gene name synonym)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650842	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766157.1|ensembl:ENSMUSG00000020770(gene)|ensembl:ENSMUST00000021116(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001764"(neuron migration)|go:"GO:0005737"(cytoplasm)|go:"GO:0005844"(polysome)|go:"GO:0046872"(metal ion binding)|go:"GO:0048667"(cell morphogenesis involved in neuron differentiation)|go:"GO:1905538"(polysome binding)|go:"GO:1990715"(mRNA CDS binding)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR036855|interpro:IPR040594|mint:Q8BL48|rcsb pdb:5ELH|rcsb pdb:5ELK	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:34652(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+7BVlzD+jczZ9/NZxDyCx1ZpGpU10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:75ED1FFD7BA105A3|rigid:XswE9oTSUDMAcTt/YEgWTcgSASU	false	sufficient binding region:685-810	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ES97	uniprotkb:Q8BWG8	intact:EBI-643369|uniprotkb:Q3UF62|uniprotkb:Q544J1|uniprotkb:Q68FE4|uniprotkb:Q6IM69|uniprotkb:Q6R8K6|uniprotkb:Q6R8K7|uniprotkb:Q6T929|uniprotkb:Q8C6D5|uniprotkb:Q8CCU2|ensembl:ENSMUSP00000065810	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:rtn3_mouse(display_long)|uniprotkb:Rtn3(gene name)|psi-mi:Rtn3(display_short)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650852	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003933.1|refseq:NP_001003934.1|refseq:NP_444306.1|refseq:NP_001258415.1|refseq:NP_001258416.1|ensembl:ENSMUSG00000024758(gene)|ensembl:ENSMUST00000065304(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:Q9ES97|reactome:R-MMU-8849932	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:33842(secondary-ac)	-	-	caution:The prey construct contains 40 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:6FGasKiLqE0qkcxmPiyTcBrk2ek10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:5C74C9E3684C09DA|rigid:Z2n6/eRugxix2+P7z0L2mafs1Ks	false	sufficient binding region:1-237	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D2R6	uniprotkb:E9PZQ0	intact:EBI-643379|uniprotkb:A2A4J6|ensembl:ENSMUSP00000017332	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:coa3_mouse(display_long)|uniprotkb:Coa3(gene name)|psi-mi:Coa3(display_short)|uniprotkb:Ccdc56(gene name synonym)|uniprotkb:Coiled-coil domain-containing protein 56(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650881	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080894.1|ensembl:ENSMUSG00000017188(gene)|ensembl:ENSMUST00000017332(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0031305"(integral component of mitochondrial inner membrane)|go:"GO:0033617"(mitochondrial cytochrome c oxidase assembly)|go:"GO:0070131"(positive regulation of mitochondrial translation)|interpro:IPR018628|interpro:IPR041752	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:33841(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ALwyf0nxz/dhGzs1Y4AUa4IFr8k10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:1566804E79376F50|rigid:X3c+c5VEv07w2TfKRhBsPHZbgMY	false	sufficient binding region:3-108	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D8U8	uniprotkb:Q91YD9	intact:EBI-643385|uniprotkb:Q543N9|ensembl:ENSMUSP00000028909|ensembl:ENSMUSP00000105657	intact:EBI-642417|ensembl:ENSMUSP00000031695	psi-mi:snx5_mouse(display_long)|uniprotkb:Snx5(gene name)|psi-mi:Snx5(display_short)	psi-mi:wasl_mouse(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650891	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001186117.1|refseq:NP_077187.1|ensembl:ENSMUST00000110030(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005903"(brush border)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006907"(pinocytosis)|go:"GO:0007174"(epidermal growth factor catabolic process)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0030904"(retromer complex)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0034452"(dynactin binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035815"(positive regulation of renal sodium excretion)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070685"(macropinocytic cup)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097422"(tubular endosome)|interpro:IPR001683(Phox-like)|interpro:IPR014637(Sorting nexin, Snx5/Snx6 types)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR028654|interpro:IPR036871|mint:Q9D8U8|rcsb pdb:5TP1|reactome:R-MMU-432722|ensembl:ENSMUST00000028909(transcript)|ensembl:ENSMUSG00000027423(gene)	refseq:NP_082735.2|ensembl:ENSMUSG00000029684(gene)|ensembl:ENSMUST00000031695(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010324"(membrane invagination)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045010"(actin nucleation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:Q91YD9|rcsb pdb:3M3N|rcsb pdb:6UHC|dip:DIP-29788N	afcs:21850(primary-reference)|afcs:33840(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fQ84XvM7jLdmmQr00Afs3oaAUBI10090	rogid:TXI8wfugOptN0kVS3yEJxaM4uq810090	intact-crc:DC91149CAB6AB6E7|rigid:5HIyM4CEMPGCTwxoF3vg26bU5zo	false	sufficient binding region:1-232	sufficient binding region:1-210	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99M51	uniprotkb:Q9EQ32	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651623	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	afcs:7326(secondary-ac)|afcs:30681(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	intact-crc:5552ACFC7F6394F4|rigid:LMzgykD9B8yEXi1abLmnSGCkbkA	false	sufficient binding region:102-358	sufficient binding region:600-811	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0DMN7	uniprotkb:P98083	intact:EBI-644529|uniprotkb:P31154|uniprotkb:P82184|uniprotkb:Q58E47|ensembl:ENSMUSP00000097528|ensembl:ENSMUSP00000159133	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:dcam1_mouse(display_long)|uniprotkb:Amd1(gene name)|psi-mi:Amd1(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652508	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033795.1|ensembl:ENSMUSG00000075232(gene)|ensembl:ENSMUST00000099945(transcript)|ensembl:ENSMUST00000238969(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004014"(adenosylmethionine decarboxylase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006557"(S-adenosylmethioninamine biosynthetic process)|go:"GO:0006597"(spermine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0019810"(putrescine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001985(S-adenosylmethionine decarboxylase)|interpro:IPR016067(S-adenosylmethionine decarboxylase, core)|interpro:IPR018166|mint:P0DMN7|reactome:R-MMU-351202	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:15663(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:C6CwoFWtQAiWB9f5Y+g8jKU0b9g10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:B7E2647580437637|rigid:9oGTPpgkS8E2pdYoS37BLmxR8+M	false	sufficient binding region:121-334	sufficient binding region:139-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0DMN7	uniprotkb:P98083	intact:EBI-644529|uniprotkb:P31154|uniprotkb:P82184|uniprotkb:Q58E47|ensembl:ENSMUSP00000097528|ensembl:ENSMUSP00000159133	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:dcam1_mouse(display_long)|uniprotkb:Amd1(gene name)|psi-mi:Amd1(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652519	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033795.1|ensembl:ENSMUSG00000075232(gene)|ensembl:ENSMUST00000099945(transcript)|ensembl:ENSMUST00000238969(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004014"(adenosylmethionine decarboxylase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006557"(S-adenosylmethioninamine biosynthetic process)|go:"GO:0006597"(spermine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0019810"(putrescine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001985(S-adenosylmethionine decarboxylase)|interpro:IPR016067(S-adenosylmethionine decarboxylase, core)|interpro:IPR018166|mint:P0DMN7|reactome:R-MMU-351202	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:15663(secondary-ac)|afcs:6875(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:C6CwoFWtQAiWB9f5Y+g8jKU0b9g10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:92A258702A6A781B|rigid:9oGTPpgkS8E2pdYoS37BLmxR8+M	false	sufficient binding region:150-334	sufficient binding region:139-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0DMN7	uniprotkb:P98083	intact:EBI-644529|uniprotkb:P31154|uniprotkb:P82184|uniprotkb:Q58E47|ensembl:ENSMUSP00000097528|ensembl:ENSMUSP00000159133	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:dcam1_mouse(display_long)|uniprotkb:Amd1(gene name)|psi-mi:Amd1(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652528	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033795.1|ensembl:ENSMUSG00000075232(gene)|ensembl:ENSMUST00000099945(transcript)|ensembl:ENSMUST00000238969(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004014"(adenosylmethionine decarboxylase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006557"(S-adenosylmethioninamine biosynthetic process)|go:"GO:0006597"(spermine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0019810"(putrescine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001985(S-adenosylmethionine decarboxylase)|interpro:IPR016067(S-adenosylmethionine decarboxylase, core)|interpro:IPR018166|mint:P0DMN7|reactome:R-MMU-351202	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:15663(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:C6CwoFWtQAiWB9f5Y+g8jKU0b9g10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:0EE89C7EA59FF308|rigid:9oGTPpgkS8E2pdYoS37BLmxR8+M	false	sufficient binding region:164-334	sufficient binding region:139-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K1I7	uniprotkb:P70315	intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652538	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:35608(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:15588C56A91A6B6B|rigid:4nUSO+BBNIBhwBLXY6nrJtpN9zw	false	sufficient binding region:365-493	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K1I7	uniprotkb:P70315	intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652548	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:35608(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:CB88E2FF7CF1EB74|rigid:4nUSO+BBNIBhwBLXY6nrJtpN9zw	false	sufficient binding region:420-491	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K1I7	uniprotkb:P70315	intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652558	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:35608(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:9A5AE062FE5600AE|rigid:4nUSO+BBNIBhwBLXY6nrJtpN9zw	false	sufficient binding region:350-493	sufficient binding region:1-231	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WTL8-4	uniprotkb:P98083	intact:EBI-644568|ensembl:ENSMUSP00000046235|ensembl:ENSMUSP00000147989	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:q9wtl8-4(display_long)|uniprotkb:Arntl(gene name)|psi-mi:Arntl(display_short)|uniprotkb:Bmal1(gene name synonym)|uniprotkb:Arnt3(gene name synonym)|uniprotkb:Brain and muscle ARNT-like 1(gene name synonym)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652568	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644534(bmal1_mouse)|ensembl:ENSMUSG00000055116(gene)|ensembl:ENSMUST00000047321(transcript)|ensembl:ENSMUST00000210238(transcript)	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:13850(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FPiSmgXh8FLT/pjtvsZPEVdyW0810090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:40D4310B9B5A55C4|rigid:hYCdndZg4DMUXnvF0rBUsjnNDRA	false	sufficient binding region:306-626	sufficient binding region:139-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P46662	uniprotkb:P18653	intact:EBI-644586|uniprotkb:Q8BR03|ensembl:ENSMUSP00000105536	intact:EBI-644577|ensembl:ENSMUSP00000003741	psi-mi:merl_mouse(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Nf2(gene name)|psi-mi:Nf2(display_short)|uniprotkb:Nf-2(gene name synonym)	psi-mi:ks6a1_mouse(display_long)|uniprotkb:90 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Mapkapk1a(gene name synonym)|uniprotkb:Ribosomal S6 kinase 1(gene name synonym)|uniprotkb:MAP kinase-activated protein kinase 1a(gene name synonym)|uniprotkb:Rps6ka1(gene name)|psi-mi:Rps6ka1(display_short)|uniprotkb:Rsk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652578	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035028.2|refseq:XP_006514633.1|ensembl:ENSMUSG00000009073(gene)|ensembl:ENSMUST00000109910(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P46662|rcsb pdb:1ISN|rcsb pdb:3WA0|interpro:IPR000798(Ezrin/radixin/moesin ERM)|rcsb pdb:4P7I|rcsb pdb:4ZRK|reactome:R-MMU-2029482|reactome:R-MMU-5627123|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|refseq:NP_001239179.1|refseq:NP_001239180.1|refseq:XP_011241971.1|refseq:NP_001239181.1|refseq:NP_001239182.1	refseq:NP_001272434.1|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000491"(positive regulation of hepatic stellate cell activation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR041906|mint:P18653|reactome:R-MMU-198753|reactome:R-MMU-199920|reactome:R-MMU-2559582|reactome:R-MMU-442742|reactome:R-MMU-444257|reactome:R-MMU-881907|ensembl:ENSMUSG00000003644(gene)|ensembl:ENSMUST00000003741(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)	afcs:15214(primary-reference)|afcs:16460(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:xDzmqR+fx4dbxWKxBm5h+sWkzEw10090	rogid:MyZEsPRYCm3wj9t6bYTg3I2LYgA10090	intact-crc:F145676034B1CB5E|rigid:KITh+DsXaO5YvPCJbrcG/FRdGkM	false	sufficient binding region:321-479	sufficient binding region:400-671	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0DMN7	uniprotkb:P70315	intact:EBI-644529|uniprotkb:P31154|uniprotkb:P82184|uniprotkb:Q58E47|ensembl:ENSMUSP00000097528|ensembl:ENSMUSP00000159133	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:dcam1_mouse(display_long)|uniprotkb:Amd1(gene name)|psi-mi:Amd1(display_short)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652589	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033795.1|ensembl:ENSMUSG00000075232(gene)|ensembl:ENSMUST00000099945(transcript)|ensembl:ENSMUST00000238969(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004014"(adenosylmethionine decarboxylase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006557"(S-adenosylmethioninamine biosynthetic process)|go:"GO:0006597"(spermine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0019810"(putrescine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001985(S-adenosylmethionine decarboxylase)|interpro:IPR016067(S-adenosylmethionine decarboxylase, core)|interpro:IPR018166|mint:P0DMN7|reactome:R-MMU-351202	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:15663(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:C6CwoFWtQAiWB9f5Y+g8jKU0b9g10090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:9CDCF4C83270CE6D|rigid:EjQoHNHp9l5v/1eivyHcUPmFosc	false	sufficient binding region:237-334	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K1I7	uniprotkb:Q9JHG7	intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741	intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400	psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym)	psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652599	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N	refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N	afcs:18478(primary-reference)|afcs:35608(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090	rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090	intact-crc:3015084E043C383D|rigid:2Gp4AmWMYxZ2LYSIBpe/7gxLNng	false	sufficient binding region:376-461	sufficient binding region:1-200	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3UKC1	uniprotkb:P98083	intact:EBI-644611|uniprotkb:Q91YT6|uniprotkb:Q9CVF0|uniprotkb:Q9DC45|ensembl:ENSMUSP00000079548	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:taxb1_mouse(display_long)|uniprotkb:Tax1bp1(gene name)|psi-mi:Tax1bp1(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652609	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080092.2|refseq:XP_006506432.1|ensembl:ENSMUSG00000004535(gene)|ensembl:ENSMUST00000080723(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q3UKC1|reactome:R-MMU-5357905|reactome:R-MMU-936440	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:35819(secondary-ac)	-	-	caution:The prey construct contains 22 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:tXfAygPlU98h9zHriu2WyD2mUG810090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:5DFB2E2290780BE5|rigid:hfVX27uJmbTnhpNkd3El8ojtjOs	false	sufficient binding region:1-256	sufficient binding region:350-577	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3UKC1	uniprotkb:P98083	intact:EBI-644611|uniprotkb:Q91YT6|uniprotkb:Q9CVF0|uniprotkb:Q9DC45|ensembl:ENSMUSP00000079548	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:taxb1_mouse(display_long)|uniprotkb:Tax1bp1(gene name)|psi-mi:Tax1bp1(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652620	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080092.2|refseq:XP_006506432.1|ensembl:ENSMUSG00000004535(gene)|ensembl:ENSMUST00000080723(transcript)|go:"GO:0006915"(apoptotic process)|go:"GO:0019900"(kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|interpro:IPR012852(Coiled-coil transcriptional coactivator-like)|interpro:IPR041611|interpro:IPR041641|mint:Q3UKC1|reactome:R-MMU-5357905|reactome:R-MMU-936440	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:35819(secondary-ac)	-	-	caution:The prey construct contains 13 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:tXfAygPlU98h9zHriu2WyD2mUG810090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:2CE8E3A4C535B39E|rigid:hfVX27uJmbTnhpNkd3El8ojtjOs	false	sufficient binding region:1-312	sufficient binding region:350-577	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6ZQ47	uniprotkb:Q8R3Z5	intact:EBI-644869	intact:EBI-644833|uniprotkb:O88517|uniprotkb:Q7TPF2|uniprotkb:Q8R3Z6|uniprotkb:Q9EPT9|uniprotkb:A2A544	psi-mi:q6zq47_mouse(display_long)|uniprotkb:Adnp(gene name)|psi-mi:Adnp(display_short)|uniprotkb:mKIAA0784(gene name synonym)	psi-mi:cacb1_mouse(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 1(gene name synonym)|uniprotkb:Cacnb1(gene name)|psi-mi:Cacnb1(display_short)|uniprotkb:Cacnlb1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653293	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|interpro:IPR038861	refseq:NP_001152791.1|refseq:NP_112450.1|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR027417|rcsb pdb:4ZW2|go:"GO:0030315"(T-tubule)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0098793"(presynapse)|reactome:R-MMU-5576892|reactome:R-MMU-5576893|reactome:R-MMU-112308|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|interpro:IPR036028	afcs:33470(primary-reference)|afcs:33470(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FLxHkQMS+u0TD3MSYfTfUjhLgr010090	rogid:e7XKbBMDfWDxQMlMoCmj8zyECCI10090	intact-crc:7785215BFF891BAF|rigid:nEhYlioqt9azmpznGVUZKeop3bk	false	sufficient binding region:44-177	sufficient binding region:1-180	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q78XY9	uniprotkb:Q99N13	intact:EBI-646416	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	psi-mi:q78xy9_mouse(display_long)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029071|refseq:NP_035794.1|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|refseq:NP_001300913.1|go:"GO:0005739"(mitochondrion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|mint:Q78XY9	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	afcs:24669(primary-reference)|afcs:16907(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Rx+/zmzxbnmSyVdMSIgp6JvjLzs10090	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	intact-crc:668504AEC6ACECA2|rigid:gIAn+w/it6YJ+0LTKJQXu00DhQ0	false	sufficient binding region:1-304	sufficient binding region:325-588	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60335	uniprotkb:Q99N13	intact:EBI-309059|ensembl:ENSMUSP00000054863	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	psi-mi:pcbp1_mouse(display_long)|uniprotkb:Pcbp1(gene name)|psi-mi:Pcbp1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656116	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035995.1|ensembl:ENSMUSG00000051695(gene)|ensembl:ENSMUST00000053015(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008494"(translation activator activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:P60335|reactome:R-MMU-72163|reactome:R-MMU-72203	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	afcs:24669(primary-reference)|afcs:18563(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:x72fawo4plQ+ipfqIoREIDHc2bA10090	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	intact-crc:7452F8FECF74E07F|rigid:6Do/QiYvF/IFJwzNpwI1kPm8vXI	false	sufficient binding region:36-356	sufficient binding region:325-588	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60335	uniprotkb:Q99N13	intact:EBI-309059|ensembl:ENSMUSP00000054863	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	psi-mi:pcbp1_mouse(display_long)|uniprotkb:Pcbp1(gene name)|psi-mi:Pcbp1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656126	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035995.1|ensembl:ENSMUSG00000051695(gene)|ensembl:ENSMUST00000053015(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008494"(translation activator activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:P60335|reactome:R-MMU-72163|reactome:R-MMU-72203	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	afcs:24669(primary-reference)|afcs:18563(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:x72fawo4plQ+ipfqIoREIDHc2bA10090	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	intact-crc:0613DE016123B216|rigid:6Do/QiYvF/IFJwzNpwI1kPm8vXI	false	sufficient binding region:76-356	sufficient binding region:325-588	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99N13	uniprotkb:P60335	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	intact:EBI-309059|ensembl:ENSMUSP00000054863	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:pcbp1_mouse(display_long)|uniprotkb:Pcbp1(gene name)|psi-mi:Pcbp1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656166	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	refseq:NP_035995.1|ensembl:ENSMUSG00000051695(gene)|ensembl:ENSMUST00000053015(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008494"(translation activator activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:P60335|reactome:R-MMU-72163|reactome:R-MMU-72203	afcs:24669(primary-reference)|afcs:18563(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	rogid:x72fawo4plQ+ipfqIoREIDHc2bA10090	intact-crc:F8241F31E0A0B860|rigid:6Do/QiYvF/IFJwzNpwI1kPm8vXI	false	sufficient binding region:325-588	sufficient binding region:95-221	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8QZX2	uniprotkb:Q60680-1	intact:EBI-646466|uniprotkb:Q3TSW5|uniprotkb:Q8BQL2|uniprotkb:Q8CIH1|ensembl:ENSMUSP00000049973	intact:EBI-646260	psi-mi:haus3_mouse(display_long)|uniprotkb:Haus3(gene name)|psi-mi:Haus3(display_short)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656228	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666271.1|reactome:R-MMU-8854518|reactome:R-MMU-5620912|ensembl:ENSMUSG00000079555(gene)|ensembl:ENSMUST00000060049(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0007098"(centrosome cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070652"(HAUS complex)|go:"GO:0072686"(mitotic spindle)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR026206|interpro:IPR032733|mint:Q8QZX2|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:55476(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AUFb4Z3nFNYMqWn1X+oAnfl4uRA10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:3A2B0F4E36CDC727|rigid:YnB5Rc5XUZsFbVVJt9gx1NIoZMM	false	sufficient binding region:436-570	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60989	uniprotkb:Q62406-1	intact:EBI-517478|uniprotkb:A2BGY6|uniprotkb:O08865|ensembl:ENSMUSP00000026978|ensembl:ENSMUSP00000061074|ensembl:ENSMUSP00000110746|ensembl:ENSMUSP00000110747	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:xiap_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 3(gene name synonym)|uniprotkb:X-linked inhibitor of apoptosis protein(gene name synonym)|uniprotkb:IAP homolog A(gene name synonym)|uniprotkb:Xiap(gene name)|psi-mi:Xiap(display_short)|uniprotkb:Aipa(gene name synonym)|uniprotkb:Api3(gene name synonym)|uniprotkb:Miha(gene name synonym)|uniprotkb:Birc4(gene name synonym)|uniprotkb:Baculoviral IAP repeat-containing protein 4(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase XIAP(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656358	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033818.2|refseq:NP_001288568.1|refseq:NP_001288570.1|refseq:XP_006541488.1|refseq:XP_006541490.1|refseq:XP_017173848.1|refseq:XP_017173849.1|refseq:XP_017173850.1|refseq:XP_017173851.1|refseq:XP_011249279.1|dip:DIP-33721N|ensembl:ENSMUSG00000025860(gene)|ensembl:ENSMUST00000026978(transcript)|ensembl:ENSMUST00000055483(transcript)|ensembl:ENSMUST00000115094(transcript)|ensembl:ENSMUST00000115095(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051402"(neuron apoptotic process)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902530"(positive regulation of protein linear polyubiquitination)|go:"GO:1990001"(inhibition of cysteine-type endopeptidase activity involved in apoptotic process)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR042579|mint:Q60989|reactome:R-MMU-111459|reactome:R-MMU-111463|reactome:R-MMU-111464|reactome:R-MMU-111469|reactome:R-MMU-3769402|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-8948747|reactome:R-MMU-8948751|reactome:R-MMU-9627069	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:15681(secondary-ac)	-	-	caution:The prey construct contains 10 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:nJHDyZvomndsRCl3vfbv33MY/c810090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:49CCEE0D41CA505C|rigid:gP9IfMr4KY1k/w2Jh9k8W21tsIM	false	sufficient binding region:1-399	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35516	uniprotkb:Q62406-1	intact:EBI-646516|uniprotkb:Q06008|uniprotkb:Q60941|ensembl:ENSMUSP00000078741|uniprotkb:G5E8J0	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:notc2_mouse(display_long)|uniprotkb:Motch B(gene name synonym)|uniprotkb:Notch2(gene name)|psi-mi:Notch2(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656378	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035058.2|dip:DIP-6008N|ensembl:ENSMUSG00000027878(gene)|ensembl:ENSMUST00000079812(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001709"(cell fate determination)|go:"GO:0001889"(liver development)|go:"GO:0001890"(placenta development)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002437"(inflammatory response to antigenic stimulus)|go:"GO:0003184"(pulmonary valve morphogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005929"(cilium)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006959"(humoral immune response)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007368"(determination of left/right symmetry)|go:"GO:0007417"(central nervous system development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009986"(cell surface)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010838"(positive regulation of keratinocyte proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030326"(embryonic limb morphogenesis)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035622"(intrahepatic bile duct development)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042060"(wound healing)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043235"(receptor complex)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045967"(negative regulation of growth rate)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046849"(bone remodeling)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060674"(placenta blood vessel development)|go:"GO:0061073"(ciliary body morphogenesis)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070986"(left/right axis specification)|go:"GO:0072014"(proximal tubule development)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:0072104"(glomerular capillary formation)|go:"GO:0072574"(hepatocyte proliferation)|go:"GO:0072576"(liver morphogenesis)|go:"GO:1990705"(cholangiocyte proliferation)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:2001204"(regulation of osteoclast development)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022336|interpro:IPR024600|interpro:IPR035993|interpro:IPR036770	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:40022(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2019/04/15	rogid:T3w0+N9gMVnbeATWbj5GW4hocwg10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:A6A3B54A0E0EF2CC|rigid:X9Hbg11SaBxt3y0mAkTNimi+x/U	false	sufficient binding region:1467-1640	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91VK1	uniprotkb:O88351	intact:EBI-646202|uniprotkb:Q9D0N4|ensembl:ENSMUSP00000020856	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:bzw2_mouse(display_long)|uniprotkb:Bzw2(gene name)|psi-mi:Bzw2(display_short)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656438	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080116.2|ensembl:ENSMUSG00000020547(gene)|ensembl:ENSMUST00000020856(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR043510|interpro:IPR016024(Armadillo-type fold)	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:55518(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JcMA6deOV3O1HtL/V+pBIn59bgU10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:DFD829D6796E360B|rigid:FEY7/Kb/61uE4Vgx8DhZojRE1BY	false	sufficient binding region:71-419	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q920A9	uniprotkb:P39429	intact:EBI-646587|uniprotkb:Q3T9Q2|uniprotkb:Q8K3U9|uniprotkb:Q8VHP5|ensembl:ENSMUSP00000124853	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:fcrla_mouse(display_long)|uniprotkb:Fc receptor-like and mucin-like protein 1(gene name synonym)|uniprotkb:Fc receptor homolog expressed in B-cells(gene name synonym)|uniprotkb:Fc receptor-related protein X(gene name synonym)|uniprotkb:Fc receptor-like protein(gene name synonym)|uniprotkb:Fcrla(gene name)|psi-mi:Fcrla(display_short)|uniprotkb:Fcrl(gene name synonym)|uniprotkb:Fcrl1(gene name synonym)|uniprotkb:Fcrlm1(gene name synonym)|uniprotkb:Fcrx(gene name synonym)|uniprotkb:Freb(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656468	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153687.1|refseq:NP_660123.1|ensembl:ENSMUSG00000038421(gene)|ensembl:ENSMUST00000159171(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:55465(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rTWm5ioHj+e+h931xJNB6dqmKnM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:F4C859EBE0A721C4|rigid:9F1n1aE+En7M/ydTvpKuj00Vqx8	false	sufficient binding region:167-295	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q920A9	uniprotkb:P39429	intact:EBI-646587|uniprotkb:Q3T9Q2|uniprotkb:Q8K3U9|uniprotkb:Q8VHP5|ensembl:ENSMUSP00000124853	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:fcrla_mouse(display_long)|uniprotkb:Fc receptor-like and mucin-like protein 1(gene name synonym)|uniprotkb:Fc receptor homolog expressed in B-cells(gene name synonym)|uniprotkb:Fc receptor-related protein X(gene name synonym)|uniprotkb:Fc receptor-like protein(gene name synonym)|uniprotkb:Fcrla(gene name)|psi-mi:Fcrla(display_short)|uniprotkb:Fcrl(gene name synonym)|uniprotkb:Fcrl1(gene name synonym)|uniprotkb:Fcrlm1(gene name synonym)|uniprotkb:Fcrx(gene name synonym)|uniprotkb:Freb(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656478	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153687.1|refseq:NP_660123.1|ensembl:ENSMUSG00000038421(gene)|ensembl:ENSMUST00000159171(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:55465(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rTWm5ioHj+e+h931xJNB6dqmKnM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:62751493C3251CDE|rigid:9F1n1aE+En7M/ydTvpKuj00Vqx8	false	sufficient binding region:221-352	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q920A9	uniprotkb:P39429	intact:EBI-646587|uniprotkb:Q3T9Q2|uniprotkb:Q8K3U9|uniprotkb:Q8VHP5|ensembl:ENSMUSP00000124853	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:fcrla_mouse(display_long)|uniprotkb:Fc receptor-like and mucin-like protein 1(gene name synonym)|uniprotkb:Fc receptor homolog expressed in B-cells(gene name synonym)|uniprotkb:Fc receptor-related protein X(gene name synonym)|uniprotkb:Fc receptor-like protein(gene name synonym)|uniprotkb:Fcrla(gene name)|psi-mi:Fcrla(display_short)|uniprotkb:Fcrl(gene name synonym)|uniprotkb:Fcrl1(gene name synonym)|uniprotkb:Fcrlm1(gene name synonym)|uniprotkb:Fcrx(gene name synonym)|uniprotkb:Freb(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656488	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153687.1|refseq:NP_660123.1|ensembl:ENSMUSG00000038421(gene)|ensembl:ENSMUST00000159171(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:55465(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rTWm5ioHj+e+h931xJNB6dqmKnM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:A94449FBAB7A99F2|rigid:9F1n1aE+En7M/ydTvpKuj00Vqx8	false	sufficient binding region:234-352	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q920A9	uniprotkb:P39429	intact:EBI-646587|uniprotkb:Q3T9Q2|uniprotkb:Q8K3U9|uniprotkb:Q8VHP5|ensembl:ENSMUSP00000124853	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:fcrla_mouse(display_long)|uniprotkb:Fc receptor-like and mucin-like protein 1(gene name synonym)|uniprotkb:Fc receptor homolog expressed in B-cells(gene name synonym)|uniprotkb:Fc receptor-related protein X(gene name synonym)|uniprotkb:Fc receptor-like protein(gene name synonym)|uniprotkb:Fcrla(gene name)|psi-mi:Fcrla(display_short)|uniprotkb:Fcrl(gene name synonym)|uniprotkb:Fcrl1(gene name synonym)|uniprotkb:Fcrlm1(gene name synonym)|uniprotkb:Fcrx(gene name synonym)|uniprotkb:Freb(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656498	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153687.1|refseq:NP_660123.1|ensembl:ENSMUSG00000038421(gene)|ensembl:ENSMUST00000159171(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:55465(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rTWm5ioHj+e+h931xJNB6dqmKnM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:5A335404ED52AC42|rigid:9F1n1aE+En7M/ydTvpKuj00Vqx8	false	sufficient binding region:256-352	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q920A9	uniprotkb:P39429	intact:EBI-646587|uniprotkb:Q3T9Q2|uniprotkb:Q8K3U9|uniprotkb:Q8VHP5|ensembl:ENSMUSP00000124853	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:fcrla_mouse(display_long)|uniprotkb:Fc receptor-like and mucin-like protein 1(gene name synonym)|uniprotkb:Fc receptor homolog expressed in B-cells(gene name synonym)|uniprotkb:Fc receptor-related protein X(gene name synonym)|uniprotkb:Fc receptor-like protein(gene name synonym)|uniprotkb:Fcrla(gene name)|psi-mi:Fcrla(display_short)|uniprotkb:Fcrl(gene name synonym)|uniprotkb:Fcrl1(gene name synonym)|uniprotkb:Fcrlm1(gene name synonym)|uniprotkb:Fcrx(gene name synonym)|uniprotkb:Freb(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656508	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153687.1|refseq:NP_660123.1|ensembl:ENSMUSG00000038421(gene)|ensembl:ENSMUST00000159171(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0030154"(cell differentiation)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:55465(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rTWm5ioHj+e+h931xJNB6dqmKnM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:EA0762BD9FABBAFC|rigid:9F1n1aE+En7M/ydTvpKuj00Vqx8	false	sufficient binding region:274-352	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60769	uniprotkb:P39429	intact:EBI-646595|uniprotkb:Q3U968|ensembl:ENSMUSP00000019997|ensembl:ENSMUSP00000101167	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnap3_mouse(display_long)|uniprotkb:Putative DNA-binding protein A20(gene name synonym)|uniprotkb:Zinc finger protein A20(gene name synonym)|uniprotkb:Tnfaip3(gene name)|psi-mi:Tnfaip3(display_short)|uniprotkb:Tnfip3(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656518	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033423.3|dip:DIP-41120N|refseq:XP_006512765.1|ensembl:ENSMUSG00000019850(gene)|ensembl:ENSMUST00000019997(transcript)|ensembl:ENSMUST00000105527(transcript)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002632"(negative regulation of granuloma formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019900"(kinase binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034148"(negative regulation of toll-like receptor 5 signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070429"(negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0072573"(tolerance induction to lipopolysaccharide)|go:"GO:0072666"(establishment of protein localization to vacuole)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR033478|mint:Q60769|rcsb pdb:5DQ6|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689896|reactome:R-MMU-936440	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:7055(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hFNjd3fxx9grjtEq3kAdU0fiFh010090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:B596D6B39CC43E97|rigid:CIST4MqK7FRHgJac87+oAxPf9rQ	false	sufficient binding region:1-401	sufficient binding region:143-343	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60769	uniprotkb:P39429	intact:EBI-646595|uniprotkb:Q3U968|ensembl:ENSMUSP00000019997|ensembl:ENSMUSP00000101167	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnap3_mouse(display_long)|uniprotkb:Putative DNA-binding protein A20(gene name synonym)|uniprotkb:Zinc finger protein A20(gene name synonym)|uniprotkb:Tnfaip3(gene name)|psi-mi:Tnfaip3(display_short)|uniprotkb:Tnfip3(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656529	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033423.3|dip:DIP-41120N|refseq:XP_006512765.1|ensembl:ENSMUSG00000019850(gene)|ensembl:ENSMUST00000019997(transcript)|ensembl:ENSMUST00000105527(transcript)|go:"GO:0001922"(B-1 B cell homeostasis)|go:"GO:0002020"(protease binding)|go:"GO:0002237"(response to molecule of bacterial origin)|go:"GO:0002315"(marginal zone B cell differentiation)|go:"GO:0002632"(negative regulation of granuloma formation)|go:"GO:0002634"(regulation of germinal center formation)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002677"(negative regulation of chronic inflammatory response)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009611"(response to wounding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0016477"(cell migration)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0019900"(kinase binding)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0034140"(negative regulation of toll-like receptor 3 signaling pathway)|go:"GO:0034148"(negative regulation of toll-like receptor 5 signaling pathway)|go:"GO:0035523"(protein K29-linked deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0042802"(identical protein binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043621"(protein self-association)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045736"(negative regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061578"(Lys63-specific deubiquitinase activity)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070429"(negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070433"(negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0070536"(protein K63-linked deubiquitination)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071947"(protein deubiquitination involved in ubiquitin-dependent protein catabolic process)|go:"GO:0072573"(tolerance induction to lipopolysaccharide)|go:"GO:0072666"(establishment of protein localization to vacuole)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1990168"(protein K33-linked deubiquitination)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000349"(negative regulation of CD40 signaling pathway)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR002653(Zinc finger, A20-type)|interpro:IPR003323(Ovarian tumour, otubain)|interpro:IPR033478|mint:Q60769|rcsb pdb:5DQ6|reactome:R-MMU-168638|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5689896|reactome:R-MMU-936440	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:7055(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hFNjd3fxx9grjtEq3kAdU0fiFh010090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:9E9ADC7F6C50FD84|rigid:CIST4MqK7FRHgJac87+oAxPf9rQ	false	sufficient binding region:1-546	sufficient binding region:143-343	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JK42	uniprotkb:O08908	intact:EBI-643530|uniprotkb:Q8VC63|ensembl:ENSMUSP00000041447	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:pdk2_mouse(display_long)|uniprotkb:Pyruvate dehydrogenase kinase isoform 2(gene name synonym)|uniprotkb:Pdk2(gene name)|psi-mi:Pdk2(display_short)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651264	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598428.2|ensembl:ENSMUSG00000038967(gene)|ensembl:ENSMUST00000038431(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006885"(regulation of pH)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR018955|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:Q9JK42|reactome:R-MMU-204174|reactome:R-MMU-5362517|interpro:IPR005467(Signal transduction histidine kinase, core)	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:34667(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:D23zOk9wYjzMwMQYSgquxlE6XVc10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:2A3D57E3341BC760|rigid:6U4qbZ56o0gVz0f1S5hMnp5A9BU	false	sufficient binding region:47-395	sufficient binding region:325-722	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JLJ0	uniprotkb:Q60591	intact:EBI-643664|uniprotkb:Q9EQI0|ensembl:ENSMUSP00000023143|ensembl:ENSMUSP00000112667	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:litaf_mouse(display_long)|uniprotkb:LITAF-like protein(gene name synonym)|uniprotkb:NEDD4 WW domain-binding protein 3(gene name synonym)|uniprotkb:Estrogen-enhanced transcript protein(gene name synonym)|uniprotkb:Litaf(gene name)|psi-mi:Litaf(display_short)|uniprotkb:N4wbp3(gene name synonym)|uniprotkb:Tbx1(gene name synonym)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651361	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064364.1|interpro:IPR037519|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007568"(aging)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050699"(WW domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|ensembl:ENSMUSG00000022500(gene)|ensembl:ENSMUST00000023143(transcript)|ensembl:ENSMUST00000117360(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005654"(nucleoplasm)|refseq:XP_006522490.1	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	afcs:53032(primary-reference)|afcs:18412(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZEM7+GSIEXmET3ixryvhuaMkiYk10090	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	intact-crc:62C06091B1DF674E|rigid:gFrHXEpgK3OQP226sNzg/95XMRg	false	sufficient binding region:8-150	sufficient binding region:200-451	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91V92	uniprotkb:Q8CFN5-4	intact:EBI-644049|ensembl:ENSMUSP00000007131|ensembl:ENSMUSP00000127632	intact:EBI-643822|ensembl:ENSMUSP00000143742	psi-mi:acly_mouse(display_long)|uniprotkb:"ATP-citrate (pro-S-)-lyase"(gene name synonym)|uniprotkb:Citrate cleavage enzyme(gene name synonym)|uniprotkb:Acly(gene name)|psi-mi:Acly(display_short)	psi-mi:q8cfn5-4(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651706	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598798.1|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR017440(ATP-citrate lyase/succinyl-CoA ligase, active site)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006084"(acetyl-CoA metabolic process)|interpro:IPR017866|interpro:IPR032263|interpro:IPR033847|interpro:IPR036291|interpro:IPR036969|mint:Q91V92|reactome:R-MMU-6798695|reactome:R-MMU-75105|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR003781(CoA-binding)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR014608(ATP-citrate synthase)|interpro:IPR016102(Succinyl-CoA synthetase-like)|ensembl:ENSMUSG00000020917(gene)|ensembl:ENSMUST00000007131(transcript)|ensembl:ENSMUST00000165111(transcript)|go:"GO:0003878"(ATP citrate synthase activity)	intact:EBI-643797(mef2c_mouse)|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000198199(transcript)	afcs:7289(primary-reference)|afcs:35254(secondary-ac)	-	isoform-comment:Contains a phosphothreonine at position 108.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c30lbMmMWWHQ2MscWeRD1ewNwxU10090	rogid:1ZAceE7Fb8MF58fpsYpHgRfA+pM10090	intact-crc:7E714BAF7FDF2974|rigid:DelsSBsAkEeJ4SspX5Lc6oexSMk	false	sufficient binding region:214-689	sufficient binding region:250-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91V92	uniprotkb:Q8CFN5-4	intact:EBI-644049|ensembl:ENSMUSP00000007131|ensembl:ENSMUSP00000127632	intact:EBI-643822|ensembl:ENSMUSP00000143742	psi-mi:acly_mouse(display_long)|uniprotkb:"ATP-citrate (pro-S-)-lyase"(gene name synonym)|uniprotkb:Citrate cleavage enzyme(gene name synonym)|uniprotkb:Acly(gene name)|psi-mi:Acly(display_short)	psi-mi:q8cfn5-4(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651716	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598798.1|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR017440(ATP-citrate lyase/succinyl-CoA ligase, active site)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006084"(acetyl-CoA metabolic process)|interpro:IPR017866|interpro:IPR032263|interpro:IPR033847|interpro:IPR036291|interpro:IPR036969|mint:Q91V92|reactome:R-MMU-6798695|reactome:R-MMU-75105|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR003781(CoA-binding)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR014608(ATP-citrate synthase)|interpro:IPR016102(Succinyl-CoA synthetase-like)|ensembl:ENSMUSG00000020917(gene)|ensembl:ENSMUST00000007131(transcript)|ensembl:ENSMUST00000165111(transcript)|go:"GO:0003878"(ATP citrate synthase activity)	intact:EBI-643797(mef2c_mouse)|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000198199(transcript)	afcs:7289(primary-reference)|afcs:35254(secondary-ac)	-	isoform-comment:Contains a phosphothreonine at position 108.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c30lbMmMWWHQ2MscWeRD1ewNwxU10090	rogid:1ZAceE7Fb8MF58fpsYpHgRfA+pM10090	intact-crc:2A61BF3F1E2D7946|rigid:DelsSBsAkEeJ4SspX5Lc6oexSMk	false	sufficient binding region:392-823	sufficient binding region:250-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49766-1	uniprotkb:P09055	intact:EBI-645309|ensembl:ENSMUSP00000025914	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:p49766-1(display_long)|uniprotkb:Vegfb(gene name)|psi-mi:Vegfb(display_short)|uniprotkb:Vrf(gene name synonym)|uniprotkb:VEGF-related factor(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654200	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645300(vegfb_mouse)|ensembl:ENSMUSG00000024962(gene)|ensembl:ENSMUST00000025914(transcript)	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:18892(primary-reference)|afcs:16928(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:EmTQbuWge35QfXvzI64Jpd42PxE10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:E96AC88ECD5BAA4A|rigid:ThkSHH2vPDlVElMo96BXvlFOASM	false	sufficient binding region:114-207	sufficient binding region:350-602	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97369	uniprotkb:Q6NZM9	intact:EBI-646407|uniprotkb:Q3TBC6|ensembl:ENSMUSP00000094084	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	psi-mi:ncf4_mouse(display_long)|uniprotkb:Neutrophil NADPH oxidase factor 4(gene name synonym)|uniprotkb:p40-phox(gene name synonym)|uniprotkb:Ncf4(gene name)|psi-mi:Ncf4(display_short)	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656082	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032703.2|refseq:XP_006520627.1|refseq:XP_006520628.1|dip:DIP-2664N|ensembl:ENSMUSG00000071715(gene)|ensembl:ENSMUST00000096357(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010008"(endosome membrane)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0045730"(respiratory burst)|go:"GO:0060090"(molecular adaptor activity)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000919(Neutrophil cytosol factor P40)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR034853|interpro:IPR034912|interpro:IPR035541|interpro:IPR036028|interpro:IPR036871|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	afcs:39293(primary-reference)|afcs:14880(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4Ehi6cs+bUQ2/65sPajJHvT9geg10090	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	intact-crc:290396405E5ED0F8|rigid:CpMSkeIphPdAbd7TU2kPYHzxot0	false	sufficient binding region:254-275	sufficient binding region:801-1076	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BP47	uniprotkb:Q6NZM9	intact:EBI-646438|uniprotkb:Q3T9A7|uniprotkb:Q7TPX0|uniprotkb:Q9CRY5|ensembl:ENSMUSP00000157402	intact:EBI-646397|uniprotkb:Q3TRZ9|uniprotkb:Q3U2J3|uniprotkb:Q3V3Y4|ensembl:ENSMUSP00000008995|ensembl:ENSMUSP00000095249	psi-mi:sync_mouse(display_long)|uniprotkb:NARS1(gene name)|psi-mi:NARS1(display_short)|uniprotkb:Asparaginyl-tRNA synthetase(gene name synonym)|uniprotkb:Asparaginyl-tRNA synthetase 1(gene name synonym)|uniprotkb:Nars(gene name synonym)	psi-mi:hdac4_mouse(display_long)|uniprotkb:Hdac4(gene name)|psi-mi:Hdac4(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656197	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001136422.1|refseq:NP_081626.2|ensembl:ENSMUSG00000024587(gene)|ensembl:ENSMUST00000237400(transcript)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004816"(asparagine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006421"(asparaginyl-tRNA aminoacylation)|go:"GO:0016477"(cell migration)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0031728"(CCR3 chemokine receptor binding)|go:"GO:0046983"(protein dimerization activity)|interpro:IPR002312(Aspartyl-tRNA synthetase, class IIb)|interpro:IPR004364("Aminoacyl-tRNA synthetase, class II (D, K and N)")|interpro:IPR004365(Nucleic acid binding, OB-fold, tRNA/helicase-type)|interpro:IPR004522(Asparaginyl-tRNA synthetase, class IIb)|interpro:IPR006195(Aminoacyl-tRNA synthetase, class II)|interpro:IPR012340(Nucleic acid-binding, OB-fold)|mint:Q8BP47	refseq:NP_997108.1|refseq:XP_017174977.1|dip:DIP-36317N|ensembl:ENSMUSG00000026313(gene)|ensembl:ENSMUST00000008995(transcript)|ensembl:ENSMUST00000097644(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0002076"(osteoblast development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006476"(protein deacetylation)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014894"(response to denervation involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016607"(nuclear speck)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030955"(potassium ion binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031672"(A band)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033235"(positive regulation of protein sumoylation)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042493"|go:"GO:0042641"(actomyosin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071374"(cellular response to parathyroid hormone stimulus)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1902437"(positive regulation of male mating behavior)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR033660|interpro:IPR037138|mint:Q6NZM9|reactome:R-MMU-350054|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-8951936	afcs:39293(primary-reference)|afcs:54930(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:xEpYdPecGJVWRFHZdcicBbtHicw10090	rogid:ijXZ/ygo/qHtrdY75fUN4SSsvxg10090	intact-crc:BB1AB2FCCFEA89C2|rigid:xgSNQpJylH/2IlGXabGHjceg1NE	false	sufficient binding region:220-559	sufficient binding region:801-1076	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BVM9	uniprotkb:Q99N13	intact:EBI-646449|ensembl:ENSMUSP00000053146	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	psi-mi:ph11a_mouse(display_long)|uniprotkb:Phf11a(gene name)|psi-mi:Phf11a(display_short)|uniprotkb:PHD finger protein 11(gene name synonym)|uniprotkb:PHD finger protein 11-like(gene name synonym)|uniprotkb:Phf11(gene name synonym)|uniprotkb:Phf11-4(gene name synonym)|uniprotkb:Phf11l(gene name synonym)	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656207	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766191.1|ensembl:ENSMUSG00000044703(gene)|ensembl:ENSMUST00000062307(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031965"(nuclear membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050776"(regulation of immune response)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034732	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	afcs:24669(primary-reference)|afcs:54972(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:thN2VCPb8qq0diqm4DjNb2h3gOU10090	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	intact-crc:35C910BDAF1EFB5B|rigid:0cqoVtZkTiX/N5l5UqT4nOcLu+U	false	sufficient binding region:28-293	sufficient binding region:325-588	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C5W4	uniprotkb:Q99N13	intact:EBI-646454|uniprotkb:B8JK02|uniprotkb:Q8CG24|ensembl:ENSMUSP00000056879|ensembl:ENSMUSP00000123354	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	psi-mi:mor2b_mouse(display_long)|uniprotkb:TCE6(gene name synonym)|uniprotkb:Morc2b(gene name)|psi-mi:Morc2b(display_short)|uniprotkb:Tce6(gene name synonym)|uniprotkb:MORC family CW-type zinc finger protein 2B(gene name synonym)	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656217	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808387.2|refseq:XP_006524320.1|refseq:XP_006524321.1|refseq:XP_006524322.1|refseq:XP_011244746.1|interpro:IPR041006|ensembl:ENSMUSG00000048602(gene)|ensembl:ENSMUST00000053896(transcript)|ensembl:ENSMUST00000131954(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0007276"(gamete generation)|go:"GO:0008270"(zinc ion binding)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990918"(double-strand break repair involved in meiotic recombination)|interpro:IPR011124(Zinc finger, CW-type)|interpro:IPR036890	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	afcs:24669(primary-reference)|afcs:54977(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:G8s7x7zhiKcNfr0rZIeqGzVxINM10090	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	intact-crc:55DBF194A732CE91|rigid:Ubq0LJYu1WQ2rqmggpBTURODOrg	false	sufficient binding region:916-1015	sufficient binding region:1-253	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99LE1	intact:EBI-688018	intact:EBI-688699|uniprotkb:Q3TB73|ensembl:ENSMUSP00000031347	afcs:35826	psi-mi:ripl2_mouse(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 2(gene name synonym)|uniprotkb:Rilpl2(gene name)|psi-mi:Rilpl2(display_short)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688695	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_084535.1|ensembl:ENSMUSG00000029401(gene)|ensembl:ENSMUST00000031347(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:4KP3	-	afcs:35826(primary-reference)|afcs:30168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BiK3OWBdnz/agb+8dWxuQdXTaFE10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:57072B1521868509|rigid:2l6ECc8b7mK4/Wab78X8vyYMUmI	false	sufficient binding region:1-197	sufficient binding region:150-465	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q99LE1	afcs:35826	intact:EBI-688699|uniprotkb:Q3TB73|ensembl:ENSMUSP00000031347	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:ripl2_mouse(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 2(gene name synonym)|uniprotkb:Rilpl2(gene name)|psi-mi:Rilpl2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688712	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_084535.1|ensembl:ENSMUSG00000029401(gene)|ensembl:ENSMUST00000031347(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:4KP3	afcs:35826(primary-reference)|afcs:30168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:BiK3OWBdnz/agb+8dWxuQdXTaFE10090	intact-crc:0F40345ED4AEFC35|rigid:2l6ECc8b7mK4/Wab78X8vyYMUmI	false	sufficient binding region:150-465	sufficient binding region:26-197	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q99LE1	afcs:35826	intact:EBI-688699|uniprotkb:Q3TB73|ensembl:ENSMUSP00000031347	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:ripl2_mouse(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 2(gene name synonym)|uniprotkb:Rilpl2(gene name)|psi-mi:Rilpl2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688723	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_084535.1|ensembl:ENSMUSG00000029401(gene)|ensembl:ENSMUST00000031347(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:4KP3	afcs:35826(primary-reference)|afcs:30168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:BiK3OWBdnz/agb+8dWxuQdXTaFE10090	intact-crc:E9A818B70B027586|rigid:2l6ECc8b7mK4/Wab78X8vyYMUmI	false	sufficient binding region:150-465	sufficient binding region:44-197	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q99LE1	afcs:35826	intact:EBI-688699|uniprotkb:Q3TB73|ensembl:ENSMUSP00000031347	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:ripl2_mouse(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 2(gene name synonym)|uniprotkb:Rilpl2(gene name)|psi-mi:Rilpl2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688745	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_084535.1|ensembl:ENSMUSG00000029401(gene)|ensembl:ENSMUST00000031347(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:4KP3	afcs:35826(primary-reference)|afcs:30168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:BiK3OWBdnz/agb+8dWxuQdXTaFE10090	intact-crc:32139ABA5862CF67|rigid:2l6ECc8b7mK4/Wab78X8vyYMUmI	false	sufficient binding region:150-465	sufficient binding region:57-197	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q9D0I9	afcs:35826	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688812	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	caution:The prey construct contains 4 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	intact-crc:1102695F15DB8989|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:150-465	sufficient binding region:1-144	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0I9	intact:EBI-688018	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	afcs:35826	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688861	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	-	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	caution:The prey construct contains 4 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:0CF96F99CDE620D6|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:1-317	sufficient binding region:150-465	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q9D0I9	afcs:35826	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688885	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	caution:The prey construct contains 2 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	intact-crc:C44011C1C33D5076|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:150-465	sufficient binding region:1-333	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	intact:EBI-688018	afcs:35826	afcs:35826	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-689087	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	-	afcs:35826(primary-reference)|afcs:35826(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:EAE8682317D80416|rigid:AMKNv4/VYXXqYnff6rYZYZpqj1Y	false	sufficient binding region:37-283	sufficient binding region:150-465	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JJK2	uniprotkb:Q9WVS7	intact:EBI-645643|ensembl:ENSMUSP00000052146|ensembl:ENSMUSP00000072723	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:lanc2_mouse(display_long)|uniprotkb:Testis-specific adriamycin sensitivity protein(gene name synonym)|uniprotkb:Lancl2(gene name)|psi-mi:Lancl2(display_short)|uniprotkb:Tasp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654591	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598498.1|ensembl:ENSMUSG00000062190(gene)|ensembl:ENSMUST00000050077(transcript)|ensembl:ENSMUST00000072954(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005975"(carbohydrate metabolic process)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|interpro:IPR007822(Lanthionine synthetase C-like)|interpro:IPR012341(Six-hairpin glycosidase)|interpro:IPR020464|mint:Q9JJK2|go:"GO:0009789"(positive regulation of abscisic acid-activated signaling pathway)	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:52596(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:839kO9ndqZ4ykJ6x2BGv8oEyhnQ10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:F3BA3FDAD92126FB|rigid:gYiEYwTpI9/W2z7CCEAR0ouB9TY	false	sufficient binding region:19-450	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26450	uniprotkb:P42337	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648679	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	afcs:15011(primary-reference)|afcs:52679(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:F87C237B1C48BBC9|rigid:5MXFlA9qywcfB/6z9jJcOYhUONo	false	sufficient binding region:339-724	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26450	uniprotkb:P42337	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648710	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	afcs:15011(primary-reference)|afcs:52679(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:CF4A92CA4EA2C719|rigid:5MXFlA9qywcfB/6z9jJcOYhUONo	false	sufficient binding region:410-724	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26450	uniprotkb:P42337	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648720	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	afcs:15011(primary-reference)|afcs:52679(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:514405B6F65675DF|rigid:5MXFlA9qywcfB/6z9jJcOYhUONo	false	sufficient binding region:479-724	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23804	uniprotkb:Q8BWG8	intact:EBI-641788|uniprotkb:Q91XK7|uniprotkb:Q61040|uniprotkb:Q64330|ensembl:ENSMUSP00000020408	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:mdm2_mouse(display_long)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:Mdm2(gene name)|psi-mi:Mdm2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648752	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034916.1|dip:DIP-24174N|dip:DIP-24196N|refseq:NP_001275515.1|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR044080|mint:P23804|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|reactome:R-MMU-198323|reactome:R-MMU-2559580|reactome:R-MMU-2559585|reactome:R-MMU-3232142|reactome:R-MMU-399719|reactome:R-MMU-5689880|reactome:R-MMU-6804756|reactome:R-MMU-6804757|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|reactome:R-MMU-6804760|reactome:R-MMU-69541|reactome:R-MMU-8941858|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|ensembl:ENSMUSG00000020184(gene)|ensembl:ENSMUST00000020408(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:7649(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:iXyzJNF2in1Qj+lXPmfZMlKWgls10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:0782DB18775C33D3|rigid:dUKLaSLCh8TD0vamqI1jX9ajpVI	false	sufficient binding region:297-489	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23804	uniprotkb:Q8BWG8	intact:EBI-641788|uniprotkb:Q91XK7|uniprotkb:Q61040|uniprotkb:Q64330|ensembl:ENSMUSP00000020408	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:mdm2_mouse(display_long)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:Mdm2(gene name)|psi-mi:Mdm2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648762	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034916.1|dip:DIP-24174N|dip:DIP-24196N|refseq:NP_001275515.1|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR044080|mint:P23804|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|reactome:R-MMU-198323|reactome:R-MMU-2559580|reactome:R-MMU-2559585|reactome:R-MMU-3232142|reactome:R-MMU-399719|reactome:R-MMU-5689880|reactome:R-MMU-6804756|reactome:R-MMU-6804757|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|reactome:R-MMU-6804760|reactome:R-MMU-69541|reactome:R-MMU-8941858|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|ensembl:ENSMUSG00000020184(gene)|ensembl:ENSMUST00000020408(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:7649(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:iXyzJNF2in1Qj+lXPmfZMlKWgls10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:CB89412792EC00F0|rigid:dUKLaSLCh8TD0vamqI1jX9ajpVI	false	sufficient binding region:334-489	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23804	uniprotkb:Q8BWG8	intact:EBI-641788|uniprotkb:Q91XK7|uniprotkb:Q61040|uniprotkb:Q64330|ensembl:ENSMUSP00000020408	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:mdm2_mouse(display_long)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:Mdm2(gene name)|psi-mi:Mdm2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648772	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034916.1|dip:DIP-24174N|dip:DIP-24196N|refseq:NP_001275515.1|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR044080|mint:P23804|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|reactome:R-MMU-198323|reactome:R-MMU-2559580|reactome:R-MMU-2559585|reactome:R-MMU-3232142|reactome:R-MMU-399719|reactome:R-MMU-5689880|reactome:R-MMU-6804756|reactome:R-MMU-6804757|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|reactome:R-MMU-6804760|reactome:R-MMU-69541|reactome:R-MMU-8941858|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|ensembl:ENSMUSG00000020184(gene)|ensembl:ENSMUST00000020408(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:7649(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:iXyzJNF2in1Qj+lXPmfZMlKWgls10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:F5062CFCF23AB52A|rigid:dUKLaSLCh8TD0vamqI1jX9ajpVI	false	sufficient binding region:379-489	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63101	uniprotkb:O54737	intact:EBI-354751|uniprotkb:P35215|uniprotkb:P70197|uniprotkb:P97286|uniprotkb:Q3TSF1|uniprotkb:Q5EBQ1|ensembl:ENSMUSP00000022894|ensembl:ENSMUSP00000105990|ensembl:ENSMUSP00000105991	intact:EBI-641814	psi-mi:1433z_mouse(display_long)|uniprotkb:Ywhaz(gene name)|psi-mi:Ywhaz(display_short)|uniprotkb:Protein kinase C inhibitor protein 1(gene name synonym)|uniprotkb:SEZ-2(gene name synonym)	psi-mi:o54737_mouse(display_long)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:BCA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648782	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001240734.1|refseq:NP_001240735.1|refseq:NP_035870.1|refseq:XP_011243654.1|ensembl:ENSMUSG00000022285(gene)|ensembl:ENSMUST00000110361(transcript)|ensembl:ENSMUST00000110362(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0003016"(respiratory system process)|ensembl:ENSMUST00000022894(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006605"(protein targeting)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0007165"(signal transduction)|go:"GO:0008039"(synaptic target recognition)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030324"(lung development)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035148"(tube formation)|go:"GO:0042470"(melanosome)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0090128"(regulation of synapse maturation)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR000308(14-3-3 protein)|interpro:IPR023409|interpro:IPR023410|interpro:IPR036815|mint:P63101|reactome:R-MMU-111447|reactome:R-MMU-3769402|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-450604|reactome:R-MMU-512988|reactome:R-MMU-5625740|reactome:R-MMU-5628897|reactome:R-MMU-75035|reactome:R-MMU-9013700|reactome:R-MMU-9614399|dip:DIP-31894N	interpro:IPR000980(SH2 motif)|interpro:IPR036860	afcs:21969(primary-reference)|afcs:50583(secondary-ac)	-	-	caution:The prey construct contains 14 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:v2N95HO8sYRWEg2gFtWiYajP1Sc10090	rogid:1zp5CTiuW80CRlnp2JGf/SHMJao10090	intact-crc:4F2486A6CD8E88A4|rigid:1jZWNANnTqQe/9BjcIkSdgeFGl8	false	sufficient binding region:1-212	sufficient binding region:1-101	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64727	uniprotkb:Q61210	intact:EBI-432047|uniprotkb:Q8BP32|uniprotkb:Q8BS46|uniprotkb:Q922C5|uniprotkb:Q922D9|ensembl:ENSMUSP00000022369	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:vinc_mouse(display_long)|uniprotkb:Metavinculin(gene name synonym)|uniprotkb:Vcl(gene name)|psi-mi:Vcl(display_short)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648794	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033528.3|ensembl:ENSMUSG00000021823(gene)|ensembl:ENSMUST00000022369(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042383"(sarcolemma)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0048675"(axon extension)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:Q64727|rcsb pdb:5Y04|reactome:R-MMU-114608|reactome:R-MMU-445355|reactome:R-MMU-5674135|reactome:R-MMU-6798695	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:15548(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bfHsrHTLESS6CIctYpg0yX3N+UA10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:A602EBCD3165E239|rigid:C6kvJGvmSayKZHJR31yiIs19xm4	false	sufficient binding region:734-1065	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64727	uniprotkb:Q61210	intact:EBI-432047|uniprotkb:Q8BP32|uniprotkb:Q8BS46|uniprotkb:Q922C5|uniprotkb:Q922D9|ensembl:ENSMUSP00000022369	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:vinc_mouse(display_long)|uniprotkb:Metavinculin(gene name synonym)|uniprotkb:Vcl(gene name)|psi-mi:Vcl(display_short)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648815	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033528.3|ensembl:ENSMUSG00000021823(gene)|ensembl:ENSMUST00000022369(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042383"(sarcolemma)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0048675"(axon extension)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:Q64727|rcsb pdb:5Y04|reactome:R-MMU-114608|reactome:R-MMU-445355|reactome:R-MMU-5674135|reactome:R-MMU-6798695	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:15548(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bfHsrHTLESS6CIctYpg0yX3N+UA10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:E1311251D6238792|rigid:C6kvJGvmSayKZHJR31yiIs19xm4	false	sufficient binding region:743-845	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P09405	uniprotkb:Q9DC51	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	intact:EBI-641852|uniprotkb:Q3TGV1|uniprotkb:Q61019|uniprotkb:A2AE36|ensembl:ENSMUSP00000000001	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:gnai3_mouse(display_long)|uniprotkb:"G(i) alpha-3"(gene name synonym)|uniprotkb:Gnai3(gene name)|psi-mi:Gnai3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648825	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)	refseq:NP_034436.1|dip:DIP-49479N|ensembl:ENSMUSG00000000001(gene)|ensembl:ENSMUST00000000001(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0042588"(zymogen granule)|go:"GO:0045121"(membrane raft)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:Q9DC51|rcsb pdb:3AB3|reactome:R-MMU-170670|reactome:R-MMU-392170|reactome:R-MMU-418594|reactome:R-MMU-9009391	afcs:21845(primary-reference)|afcs:7110(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	rogid:YJ4mEQU/4IYIxCCj7qgeNh92TNc10090	intact-crc:796262A4FE036C19|rigid:SU6t2RQ0hFzKVIeIYWp/nZIkl/4	false	sufficient binding region:52-167	sufficient binding region:2-354	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P09405	uniprotkb:Q9DC51	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	intact:EBI-641852|uniprotkb:Q3TGV1|uniprotkb:Q61019|uniprotkb:A2AE36|ensembl:ENSMUSP00000000001	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:gnai3_mouse(display_long)|uniprotkb:"G(i) alpha-3"(gene name synonym)|uniprotkb:Gnai3(gene name)|psi-mi:Gnai3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648836	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)	refseq:NP_034436.1|dip:DIP-49479N|ensembl:ENSMUSG00000000001(gene)|ensembl:ENSMUST00000000001(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0042588"(zymogen granule)|go:"GO:0045121"(membrane raft)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:Q9DC51|rcsb pdb:3AB3|reactome:R-MMU-170670|reactome:R-MMU-392170|reactome:R-MMU-418594|reactome:R-MMU-9009391	afcs:21845(primary-reference)|afcs:7110(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	rogid:YJ4mEQU/4IYIxCCj7qgeNh92TNc10090	intact-crc:7C9F6605919F1FCF|rigid:SU6t2RQ0hFzKVIeIYWp/nZIkl/4	false	sufficient binding region:199-320	sufficient binding region:2-354	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P09405	uniprotkb:Q9DC51	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	intact:EBI-641852|uniprotkb:Q3TGV1|uniprotkb:Q61019|uniprotkb:A2AE36|ensembl:ENSMUSP00000000001	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:gnai3_mouse(display_long)|uniprotkb:"G(i) alpha-3"(gene name synonym)|uniprotkb:Gnai3(gene name)|psi-mi:Gnai3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648846	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)	refseq:NP_034436.1|dip:DIP-49479N|ensembl:ENSMUSG00000000001(gene)|ensembl:ENSMUST00000000001(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0042588"(zymogen granule)|go:"GO:0045121"(membrane raft)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:Q9DC51|rcsb pdb:3AB3|reactome:R-MMU-170670|reactome:R-MMU-392170|reactome:R-MMU-418594|reactome:R-MMU-9009391	afcs:21845(primary-reference)|afcs:7110(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	rogid:YJ4mEQU/4IYIxCCj7qgeNh92TNc10090	intact-crc:EB6622EB6FB2A1F0|rigid:SU6t2RQ0hFzKVIeIYWp/nZIkl/4	false	sufficient binding region:268-436	sufficient binding region:2-354	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99N72	uniprotkb:Q61039	intact:EBI-641874	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648877	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	afcs:23263(primary-reference)|afcs:16151(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	intact-crc:92F0EE8B3C57B896|rigid:oMeB7lnkJZRX3/TyHvb/EmC9jaM	false	sufficient binding region:325-432	sufficient binding region:1-195	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62276	uniprotkb:Q99N72	intact:EBI-641886|uniprotkb:A2ALA2|uniprotkb:Q3TTZ9|ensembl:ENSMUSP00000015920	intact:EBI-641874	psi-mi:med22_mouse(display_long)|uniprotkb:Surfeit locus protein 5(gene name synonym)|uniprotkb:Med22(gene name)|psi-mi:Med22(display_short)|uniprotkb:Mediator complex subunit 22(gene name synonym)|uniprotkb:Surf5(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648897	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001029080.1|refseq:NP_035643.1|ensembl:ENSMUSG00000015776(gene)|ensembl:ENSMUST00000015920(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016592"(mediator complex)|interpro:IPR009332(Surfeit locus 5)|rcsb pdb:6W1S	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:16816(secondary-ac)	-	-	caution:The prey construct contains 47 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Xfhw+0PALW3KNg2gQXOCTPwxBKo10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:F5EE7522AC1D6196|rigid:wZ1DLKgCPjamahk2rjAbS35WDOk	false	sufficient binding region:1-88	sufficient binding region:325-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P13020	uniprotkb:Q8CIH5	intact:EBI-445180|uniprotkb:Q3UPB1|uniprotkb:Q8R590|intact:EBI-4281654|ensembl:ENSMUSP00000028239	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:gels_mouse(display_long)|uniprotkb:Actin-depolymerizing factor(gene name synonym)|uniprotkb:Brevin(gene name synonym)|uniprotkb:Gsn(gene name)|psi-mi:Gsn(display_short)|uniprotkb:Gsb(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648908	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666232.2|ensembl:ENSMUSG00000026879(gene)|ensembl:ENSMUST00000028239(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002102"(podosome)|go:"GO:0003779"(actin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006915"(apoptotic process)|go:"GO:0007417"(central nervous system development)|go:"GO:0007568"(aging)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014891"(striated muscle atrophy)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0016528"(sarcoplasm)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030042"(actin filament depolymerization)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030478"(actin cap)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031648"(protein destabilization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036313"(phosphatidylinositol 3-kinase catalytic subunit binding)|go:"GO:0042060"(wound healing)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043209"(myelin sheath)|go:"GO:0045010"(actin nucleation)|go:"GO:0045159"(myosin II binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045471"(response to ethanol)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051014"(actin filament severing)|go:"GO:0051015"(actin filament binding)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0051593"(response to folic acid)|go:"GO:0051693"(actin filament capping)|go:"GO:0055119"(relaxation of cardiac muscle)|go:"GO:0060271"(cilium assembly)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071801"(regulation of podosome assembly)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0090527"(actin filament reorganization)|go:"GO:0097017"(renal protein absorption)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:1902174"(positive regulation of keratinocyte apoptotic process)|go:"GO:1903903"(regulation of establishment of T cell polarity)|go:"GO:1903906"(regulation of plasma membrane raft polarization)|go:"GO:1903909"(regulation of receptor clustering)|go:"GO:1903923"(positive regulation of protein processing in phagocytic vesicle)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:2001269"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|interpro:IPR007122(Gelsolin)|interpro:IPR007123(Gelsolin region)|interpro:IPR029006|interpro:IPR030004|mint:P13020|rcsb pdb:1NPH|rcsb pdb:4CBU|rcsb pdb:4CBW|rcsb pdb:4CBX|rcsb pdb:5MVV|rcsb pdb:6I4D|rcsb pdb:6I4E|rcsb pdb:6I4F|rcsb pdb:6I4G|rcsb pdb:6I4H|rcsb pdb:6I4I|rcsb pdb:6I4J|rcsb pdb:6I4K|rcsb pdb:6I4L|rcsb pdb:6I4M|reactome:R-MMU-264870|reactome:R-MMU-6798695|dip:DIP-31941N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:16113(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:vByKB6qbsPzebkkufeXoP6n0SUI10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:297BA504330F4D43|rigid:6JT9GoFxLYRjv1ISc6xua8+MBvk	false	sufficient binding region:46-486	sufficient binding region:1030-1265	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0F1	uniprotkb:Q8CIH5	intact:EBI-309872|uniprotkb:Q3TQT6|uniprotkb:Q3UWM5|uniprotkb:Q99P70|ensembl:ENSMUSP00000024851	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:ndc80_mouse(display_long)|uniprotkb:Ndc80(gene name)|psi-mi:Ndc80(display_short)|uniprotkb:Hec1(gene name synonym)|uniprotkb:Kntc2(gene name synonym)|uniprotkb:Kinetochore protein Hec1(gene name synonym)|uniprotkb:Kinetochore-associated protein 2(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648919	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075783.2|ensembl:ENSMUSG00000024056(gene)|ensembl:ENSMUST00000024851(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008315"(G2/MI transition of meiotic cell cycle)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0030332"(cyclin binding)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042802"(identical protein binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|interpro:IPR040967|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:1905342"(positive regulation of protein localization to kinetochore)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:24528(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:CaqRdQ6QaqDLOgDm6iglxpgvlaI10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:FA017015BA3F3274|rigid:u00yBMnXLaPa9PC8QyP4o+yZpbM	false	sufficient binding region:11-329	sufficient binding region:1030-1265	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0F1	uniprotkb:Q8CIH5	intact:EBI-309872|uniprotkb:Q3TQT6|uniprotkb:Q3UWM5|uniprotkb:Q99P70|ensembl:ENSMUSP00000024851	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:ndc80_mouse(display_long)|uniprotkb:Ndc80(gene name)|psi-mi:Ndc80(display_short)|uniprotkb:Hec1(gene name synonym)|uniprotkb:Kntc2(gene name synonym)|uniprotkb:Kinetochore protein Hec1(gene name synonym)|uniprotkb:Kinetochore-associated protein 2(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648929	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075783.2|ensembl:ENSMUSG00000024056(gene)|ensembl:ENSMUST00000024851(transcript)|go:"GO:0000070"(mitotic sister chromatid segregation)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000776"(kinetochore)|go:"GO:0000940"(outer kinetochore)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007052"(mitotic spindle organization)|go:"GO:0007057"(spindle assembly involved in female meiosis I)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008315"(G2/MI transition of meiotic cell cycle)|go:"GO:0008608"(attachment of spindle microtubules to kinetochore)|go:"GO:0030332"(cyclin binding)|go:"GO:0031262"(Ndc80 complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0042802"(identical protein binding)|go:"GO:0051298"(centrosome duplication)|go:"GO:0051301"(cell division)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|go:"GO:0090267"(positive regulation of mitotic cell cycle spindle assembly checkpoint)|interpro:IPR005550(HEC/Ndc80p)|interpro:IPR038273|interpro:IPR040967|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|go:"GO:1905342"(positive regulation of protein localization to kinetochore)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:24528(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:CaqRdQ6QaqDLOgDm6iglxpgvlaI10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:46C8C7E449FA7FAE|rigid:u00yBMnXLaPa9PC8QyP4o+yZpbM	false	sufficient binding region:35-259	sufficient binding region:1030-1265	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:Q8CIH5	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648939	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:12352(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:59694A8129843F16|rigid:aXgA30jhaawG0MyOtwxBf+Cj2NY	false	sufficient binding region:431-578	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:Q8CIH5	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648960	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:12352(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:2BC27E3F450CE0D7|rigid:aXgA30jhaawG0MyOtwxBf+Cj2NY	false	sufficient binding region:554-858	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:Q8CIH5	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648980	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:12352(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:EF16680A32530022|rigid:aXgA30jhaawG0MyOtwxBf+Cj2NY	false	sufficient binding region:624-791	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:Q8CIH5	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648990	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:12352(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:AA3FB3AF017A60F8|rigid:aXgA30jhaawG0MyOtwxBf+Cj2NY	false	sufficient binding region:626-853	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40124	uniprotkb:Q8CIH5	intact:EBI-641927|intact:EBI-2308504|uniprotkb:Q8BPT7|ensembl:ENSMUSP00000068260|ensembl:ENSMUSP00000101862|ensembl:ENSMUSP00000101864	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:cap1_mouse(display_long)|uniprotkb:Cap1(gene name)|psi-mi:Cap1(display_short)|uniprotkb:Cap(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649010	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287996.1|refseq:NP_031624.2|refseq:XP_006502758.1|refseq:XP_006502760.1|ensembl:ENSMUSG00000028656(gene)|ensembl:ENSMUST00000069533(transcript)|ensembl:ENSMUST00000106255(transcript)|ensembl:ENSMUST00000106257(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045761"(regulation of adenylate cyclase activity)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP,  C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028415|interpro:IPR028417|interpro:IPR036222|interpro:IPR036223|mint:P40124|rcsb pdb:6FM2|rcsb pdb:6RSQ|rcsb pdb:6RSW|reactome:R-MMU-6798695|dip:DIP-49641N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:6230(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Qgj2tTTmQRMu8qVRerwwxesJu/810090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:E9148C2F7FB3499E|rigid:7CNUPQPeyJPQcKI1dsmcpxGVwe8	false	sufficient binding region:229-462	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60838	uniprotkb:Q8CIH5	intact:EBI-641940|uniprotkb:Q7TN14|ensembl:ENSMUSP00000099635|ensembl:ENSMUSP00000140073|ensembl:ENSMUSP00000019362	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:dvl2_mouse(display_long)|uniprotkb:Dvl2(gene name)|psi-mi:Dvl2(display_short)|uniprotkb:DSH homolog 2(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649020	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031914.3|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0061098"(positive regulation of protein tyrosine kinase activity)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0090179"(planar cell polarity pathway involved in neural tube closure)|go:"GO:0150012"(positive regulation of neuron projection arborization)|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001158(DIX)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR003351(Dishevelled protein)|interpro:IPR008339(Dishevelled region)|interpro:IPR008341(Dishevelled-2 region)|interpro:IPR015506(Dishevelled related protein)|interpro:IPR024580|interpro:IPR029071|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|interpro:IPR038207|mint:Q60838|rcsb pdb:3ML6|rcsb pdb:6VCC|reactome:R-MMU-201688|reactome:R-MMU-2028269|reactome:R-MMU-4086400|reactome:R-MMU-4608870|reactome:R-MMU-4641258|reactome:R-MMU-4641262|reactome:R-MMU-5099900|reactome:R-MMU-5663220|reactome:R-MMU-8856825|reactome:R-MMU-8856828|ensembl:ENSMUST00000019362(transcript)|ensembl:ENSMUST00000102575(transcript)|ensembl:ENSMUST00000190940(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005109"(frizzled binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007379"(segment specification)|go:"GO:0007507"(heart development)|go:"GO:0016235"(aggresome)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022007"(convergent extension involved in neural plate elongation)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035282"(segmentation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0044340"(canonical Wnt signaling pathway involved in regulation of cell proliferation)|go:"GO:0045177"(apical part of cell)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0060029"(convergent extension involved in organogenesis)|ensembl:ENSMUSG00000020888(gene)|dip:DIP-29399N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:14218(secondary-ac)	-	-	caution:The prey construct contains 6 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bFjXy0cGGbY8YE60qW3+0NLpqNs10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:158FD3A0D031627D|rigid:4Ms5Q/5V2G4/gx+npL6MgI4V7Vw	false	sufficient binding region:1-441	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11276	uniprotkb:Q8CIH5	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649031	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:20361(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:6598155A5E1367FF|rigid:x/++3sbgbKrqW7GypmEYl9Px7Qk	false	sufficient binding region:1-255	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11276	uniprotkb:Q8CIH5	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649051	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:20361(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:E8D0DE8BA528B285|rigid:x/++3sbgbKrqW7GypmEYl9Px7Qk	false	sufficient binding region:675-1032	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZL0	uniprotkb:Q8CIH5	intact:EBI-641983	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:q9czl0_mouse(display_long)|uniprotkb:Tmed9(gene name)|psi-mi:Tmed9(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649091	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR009038(GOLD)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|mint:Q9CZL0|interpro:IPR015720(TMP21 related)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:30361(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rKuz3DrdNghlaIyFXzcGdSCBg+A10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:DFCA15C4AA3F5D9E|rigid:ctnj2NV0qknq6/+ch+slQf9j3fk	false	sufficient binding region:53-180	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BTM8	uniprotkb:Q8CIH5	intact:EBI-641991|uniprotkb:B7FAV0|uniprotkb:O54934|uniprotkb:Q7TQI1|uniprotkb:Q8BLK1|uniprotkb:Q8BTN7|uniprotkb:Q8VHX5|uniprotkb:Q8VHX8|uniprotkb:Q99KQ2|ensembl:ENSMUSP00000033699	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:flna_mouse(display_long)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)|uniprotkb:Flna(gene name)|psi-mi:Flna(display_short)|uniprotkb:Fln(gene name synonym)|uniprotkb:Fln1(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006527974.1|ensembl:ENSMUST00000033699(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|ensembl:ENSMUSG00000031328(gene)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0097368"(establishment of Sertoli cell barrier)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q8BTM8|reactome:R-MMU-114608|reactome:R-MMU-430116|reactome:R-MMU-446353|reactome:R-MMU-5627123	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:21359(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hp3whHs7nFMTtChpQ/KywkPalq810090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:EE0C192637098AA8|rigid:g5G1GEKzMJq9mZe7ytj9rPc+kf0	false	sufficient binding region:1501-2172	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62158	uniprotkb:Q8CIH5	intact:EBI-642025|uniprotkb:Q62157|uniprotkb:Q8C2Q5|uniprotkb:Q99LK1|ensembl:ENSMUSP00000021761|ensembl:ENSMUSP00000152730	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:tri27_mouse(display_long)|uniprotkb:Ret finger protein(gene name synonym)|uniprotkb:Tripartite motif-containing protein 27(gene name synonym)|uniprotkb:Trim27(gene name)|psi-mi:Trim27(display_short)|uniprotkb:Rfp(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM27(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033080.2|refseq:XP_006516669.1|go:"GO:0019901"(protein kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045087"(innate immune response)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0016605"(PML body)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090281"(negative regulation of calcium ion import)|go:"GO:1902187"|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035791|interpro:IPR043136|mint:Q62158|reactome:R-MMU-3232142|reactome:R-MMU-8948751|ensembl:ENSMUSG00000021326(gene)|ensembl:ENSMUST00000021761(transcript)|ensembl:ENSMUST00000222544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001650"(fibrillar center)|go:"GO:0002820"(negative regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:15182(secondary-ac)	-	-	caution:The prey construct contains 31 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ay3vOvfbC0rFrDbLB0NsvrT9eBw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:01E31FA180035016|rigid:MBpHTSCNayiq3GPwOCKBdGFtaKQ	false	sufficient binding region:1-70	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QXV8	uniprotkb:Q8CIH5	intact:EBI-642040|uniprotkb:Q9WUQ9|ensembl:ENSMUSP00000022709	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:spy2_mouse(display_long)|uniprotkb:Spry2(gene name)|psi-mi:Spry2(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649172	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036027.1|refseq:XP_006519079.1|ensembl:ENSMUSG00000022114(gene)|ensembl:ENSMUST00000022709(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007605"(sensory perception of sound)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010719"(negative regulation of epithelial to mesenchymal transition)|go:"GO:0010801"(negative regulation of peptidyl-threonine phosphorylation)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030324"(lung development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042472"(inner ear morphogenesis)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045165"(cell fate commitment)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048513"(animal organ development)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051387"(negative regulation of neurotrophin TRK receptor signaling pathway)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060437"(lung growth)|go:"GO:0060449"(bud elongation involved in lung branching)|go:"GO:0060541"(respiratory system development)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1902747"(negative regulation of lens fiber cell differentiation)|go:"GO:1990752"(microtubule end)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR007875(Sprouty)|interpro:IPR030780|reactome:R-MMU-1295596|reactome:R-MMU-182971	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:17072(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0GYJP3Sry0WKCVvkI5BHETZdFz410090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:1924C5ED5E5F22E9|rigid:62jhAxgT6h+GUXDVNwBfrl7S/8A	false	sufficient binding region:76-315	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52623	uniprotkb:Q8CIH5	intact:EBI-642050	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:uck1_mouse(display_long)|uniprotkb:Uridine monophosphokinase 1(gene name synonym)|uniprotkb:Cytidine monophosphokinase 1(gene name synonym)|uniprotkb:Uck1(gene name)|psi-mi:Uck1(display_short)|uniprotkb:Umpk(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649182	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029920|refseq:NP_035805.2|interpro:IPR006083(Phosphoribulokinase/uridine kinase)|interpro:IPR000764(Uridine kinase)|go:"GO:0004849"(uridine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0044206"(UMP salvage)|go:"GO:0044211"(CTP salvage)|reactome:R-MMU-73614|interpro:IPR027417|mint:P52623	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:22948(secondary-ac)	-	-	caution:The prey construct contains 60 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:IqwShkdFQsI4urY2hkV6rOWYw0M10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:EAC7B93298B44AEC|rigid:zKv61n+zHqiBV7FiuigklW/ie1A	false	sufficient binding region:1-277	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35658	uniprotkb:Q02956	intact:EBI-642072	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	psi-mi:c1qbp_mouse(display_long)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:GC1q-R protein(gene name synonym)|uniprotkb:C1qbp(gene name)|psi-mi:C1qbp(display_short)|uniprotkb:Gc1qbp(gene name synonym)	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649193	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-140837|reactome:R-MMU-8980692|reactome:R-MMU-9013106|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|dip:DIP-32249N	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	afcs:15028(primary-reference)|afcs:13952(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:tPoLimqgF2SXeVXk7Z5rCQa+wTc10090	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	intact-crc:81DD4F0A04716859|rigid:FjD2bJJRG6ZnO5sEagDO03ih+14	false	sufficient binding region:4-278	sufficient binding region:100-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49070	uniprotkb:E9PZQ0	intact:EBI-309114|uniprotkb:Q99JU5|ensembl:ENSMUSP00000021963	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:camlg_mouse(display_long)|uniprotkb:Camlg(gene name)|psi-mi:Camlg(display_short)|uniprotkb:Caml(gene name synonym)|uniprotkb:Calcium signal-modulating cyclophilin ligand(gene name synonym)|uniprotkb:Get2(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649225	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031622.2|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043529"(GET complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|interpro:IPR016719(Calcium signal-modulating cyclophilin ligand)|mint:P49070|ensembl:ENSMUSG00000021501(gene)|ensembl:ENSMUST00000021963(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001881"(receptor recycling)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:13971(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	caution:The prey construct contains 6 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:WhoJPAp432WGS6e6/wAiilnkJPM10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:2F7B30807F35C41B|rigid:zzEEgYClCcsYSld7uMEXh2EUmwg	false	sufficient binding region:1-170	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49070	uniprotkb:E9PZQ0	intact:EBI-309114|uniprotkb:Q99JU5|ensembl:ENSMUSP00000021963	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:camlg_mouse(display_long)|uniprotkb:Camlg(gene name)|psi-mi:Camlg(display_short)|uniprotkb:Caml(gene name synonym)|uniprotkb:Calcium signal-modulating cyclophilin ligand(gene name synonym)|uniprotkb:Get2(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649235	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031622.2|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043529"(GET complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|interpro:IPR016719(Calcium signal-modulating cyclophilin ligand)|mint:P49070|ensembl:ENSMUSG00000021501(gene)|ensembl:ENSMUST00000021963(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001881"(receptor recycling)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:13971(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:WhoJPAp432WGS6e6/wAiilnkJPM10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:794A7B8818682043|rigid:zzEEgYClCcsYSld7uMEXh2EUmwg	false	sufficient binding region:1-294	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JK38	uniprotkb:E9PZQ0	intact:EBI-642101|ensembl:ENSMUSP00000042860|ensembl:ENSMUSP00000154084	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:gna1_mouse(display_long)|uniprotkb:Phosphoglucosamine transacetylase(gene name synonym)|uniprotkb:Phosphoglucosamine acetylase(gene name synonym)|uniprotkb:Gnpnat1(gene name)|psi-mi:Gnpnat1(display_short)|uniprotkb:Gna1(gene name synonym)|uniprotkb:Protein EMeg32(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649245	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062298.1|refseq:XP_006519338.1|refseq:XP_006519339.1|ensembl:ENSMUSG00000037722(gene)|ensembl:ENSMUST00000046191(transcript)|ensembl:ENSMUST00000227468(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0004343"(glucosamine 6-phosphate N-acetyltransferase activity)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006041"(glucosamine metabolic process)|go:"GO:0006044"(N-acetylglucosamine metabolic process)|go:"GO:0006048"(UDP-N-acetylglucosamine biosynthetic process)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0010008"(endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000182(GCN5-related N-acetyltransferase)|interpro:IPR016181(Acyl-CoA N-acyltransferase)|interpro:IPR039143|reactome:R-MMU-446210	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:18055(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	caution:The prey construct contains 21 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JGxZdNcl+pvAJkatvJPdPzK+whw10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:2FB146EDC843A9E1|rigid:dDNL2WbzfvhZ/OY8Ku1Cl0U9Knc	false	sufficient binding region:1-171	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63089	uniprotkb:E9PZQ0	intact:EBI-642112|uniprotkb:P20935|ensembl:ENSMUSP00000099073	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:ptn_mouse(display_long)|uniprotkb:Heparin-binding growth-associated molecule(gene name synonym)|uniprotkb:Heparin-binding growth factor 8(gene name synonym)|uniprotkb:Osteoblast-specific factor 1(gene name synonym)|uniprotkb:Heparin-binding neutrophic factor(gene name synonym)|uniprotkb:Heparin-binding brain mitogen(gene name synonym)|uniprotkb:Ptn(gene name)|psi-mi:Ptn(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649256	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032999.1|refseq:XP_006505820.2|ensembl:ENSMUSG00000029838(gene)|ensembl:ENSMUST00000101534(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001889"(liver development)|go:"GO:0002232"(leukocyte chemotaxis involved in inflammatory response)|go:"GO:0002690"(positive regulation of leukocyte chemotaxis)|go:"GO:0004864"(protein phosphatase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005178"(integrin binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005539"(glycosaminoglycan binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007507"(heart development)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0008083"(growth factor activity)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0010996"(response to auditory stimulus)|go:"GO:0014823"(response to activity)|go:"GO:0016020"(membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021510"(spinal cord development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031104"(dendrite regeneration)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032355"(response to estradiol)|go:"GO:0021794"(thalamus development)|go:"GO:0032570"(response to progesterone)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034644"(cellular response to UV)|go:"GO:0035373"(chondroitin sulfate proteoglycan binding)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042246"(tissue regeneration)|go:"GO:0042493"|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0038085"(vascular endothelial growth factor binding)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0043932"(ossification involved in bone remodeling)|go:"GO:0044849"(estrous cycle)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045545"(syndecan binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045837"(negative regulation of membrane potential)|go:"GO:0046697"(decidualization)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048477"(oogenesis)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0048714"(positive regulation of oligodendrocyte differentiation)|go:"GO:0050680"(negative regulation of epithelial cell proliferation)|go:"GO:0051781"(positive regulation of cell division)|go:"GO:0060221"(retinal rod cell differentiation)|go:"GO:0060253"(negative regulation of glial cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0072201"(negative regulation of mesenchymal cell proliferation)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0140059"(dendrite arborization)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900272"(negative regulation of long-term synaptic potentiation)|go:"GO:1903706"(regulation of hemopoiesis)|go:"GO:1904373"(response to kainic acid)|go:"GO:1904389"(rod bipolar cell differentiation)|go:"GO:1904391"(response to ciliary neurotrophic factor)|go:"GO:1904395"(positive regulation of skeletal muscle acetylcholine-gated channel clustering)|go:"GO:1904397"(negative regulation of neuromuscular junction development)|go:"GO:1904399"(heparan sulfate binding)|go:"GO:1990089"(response to nerve growth factor)|go:"GO:2000036"(regulation of stem cell population maintenance)|go:"GO:2000347"(positive regulation of hepatocyte proliferation)|go:"GO:2000738"(positive regulation of stem cell differentiation)|interpro:IPR000762(PTN/MK heparin-binding protein)|interpro:IPR020089|interpro:IPR020090|interpro:IPR020091|interpro:IPR020092|interpro:IPR037122|interpro:IPR038130|mint:P63089	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23569(secondary-ac)|afcs:23471(primary-reference)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	caution:The prey construct contains 47 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:vhMcwa6Ap7TwOs1H8qFEI2NcO8I10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:C76D9D0388492191|rigid:dcqaxn4qz57DCswCmHXE+bJRI6U	false	sufficient binding region:1-167	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11157	uniprotkb:E9PZQ0	intact:EBI-642122|uniprotkb:Q3UI23|uniprotkb:Q542E2|ensembl:ENSMUSP00000020980	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:rir2_mouse(display_long)|uniprotkb:Ribonucleotide reductase small subunit(gene name synonym)|uniprotkb:Ribonucleotide reductase small chain(gene name synonym)|uniprotkb:Rrm2(gene name)|psi-mi:Rrm2(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649266	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033130.1|ensembl:ENSMUSG00000020649(gene)|ensembl:ENSMUST00000020980(transcript)|go:"GO:0001824"(blastocyst development)|go:"GO:0004748"(ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005829"(cytosol)|go:"GO:0005971"(ribonucleoside-diphosphate reductase complex)|go:"GO:0006260"(DNA replication)|go:"GO:0008199"(ferric iron binding)|go:"GO:0009262"(deoxyribonucleotide metabolic process)|go:"GO:0009263"(deoxyribonucleotide biosynthetic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|interpro:IPR000358(Ribonucleotide reductase)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR012348(Ribonucleotide reductase-related)|interpro:IPR030475|interpro:IPR033909|rcsb pdb:1AFT|rcsb pdb:1H0N|rcsb pdb:1H0O|rcsb pdb:1W68|rcsb pdb:1W69|rcsb pdb:1XSM|reactome:R-MMU-499943	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:15221(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	caution:The prey construct contains 16 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:N07SRKES0es3qYdVHDCNKyPVW3s10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:A4411ABD87F73C26|rigid:ozkllakcbpfGr+TD8KnVye6+7i0	false	sufficient binding region:1-390	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:E9PZQ0	uniprotkb:P0C0S6	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	intact:EBI-642131|uniprotkb:P17317|uniprotkb:Q3UA55|uniprotkb:Q3UK43|uniprotkb:Q68FD2|uniprotkb:B2RXZ3|ensembl:ENSMUSP00000036907	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:h2az_mouse(display_long)|uniprotkb:H2az1(gene name)|psi-mi:H2az1(display_short)|uniprotkb:H2afz(gene name synonym)|uniprotkb:H2az(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649277	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	refseq:NP_058030.1|ensembl:ENSMUSG00000037894(gene)|ensembl:ENSMUST00000041045(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|reactome:R-MMU-606279|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-9670095|reactome:R-MMU-5625886|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S6|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-212300|reactome:R-MMU-2299718|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-427359|reactome:R-MMU-427413|go:"GO:0032869"(cellular response to insulin stimulus)|reactome:R-MMU-5250924|reactome:R-MMU-5578749	afcs:23471(primary-reference)|afcs:17709(secondary-ac)	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	rogid:0FrzM1TXlduSQ0NNVl0C9uqCUGI10090	intact-crc:21DE021F4F4918A7|rigid:mWTkBh1TGxDRDxY48Arq2BsCmHk	false	sufficient binding region:4917-5035	sufficient binding region:2-128	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1R2	uniprotkb:Q9DC51	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-641852|uniprotkb:Q3TGV1|uniprotkb:Q61019|uniprotkb:A2AE36|ensembl:ENSMUSP00000000001	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:gnai3_mouse(display_long)|uniprotkb:"G(i) alpha-3"(gene name synonym)|uniprotkb:Gnai3(gene name)|psi-mi:Gnai3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649287	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	refseq:NP_034436.1|dip:DIP-49479N|ensembl:ENSMUSG00000000001(gene)|ensembl:ENSMUST00000000001(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0042588"(zymogen granule)|go:"GO:0045121"(membrane raft)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:Q9DC51|rcsb pdb:3AB3|reactome:R-MMU-170670|reactome:R-MMU-392170|reactome:R-MMU-418594|reactome:R-MMU-9009391	afcs:21845(primary-reference)|afcs:24064(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:YJ4mEQU/4IYIxCCj7qgeNh92TNc10090	intact-crc:C5B9C78209843750|rigid:ngVn9dfWyuSBOlisnwMsFHHczz0	false	sufficient binding region:56-183	sufficient binding region:2-354	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8C3J5	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651758	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455	afcs:30822(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090	intact-crc:190420DBC6BF9078|rigid:aT2UECmyg6vi0OKKdTYme6ZLgKg	false	sufficient binding region:210-727	sufficient binding region:1-200	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8C3J5	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651769	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455	afcs:30822(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090	intact-crc:A75B2FCD7DDF3749|rigid:aT2UECmyg6vi0OKKdTYme6ZLgKg	false	sufficient binding region:536-727	sufficient binding region:1-200	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QZH6	uniprotkb:P70196	intact:EBI-527020|uniprotkb:Q91V53	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:ecsit_mouse(display_long)|uniprotkb:Protein SITPEC(gene name synonym)|uniprotkb:Ecsit(gene name)|psi-mi:Ecsit(display_short)|uniprotkb:Sitpec(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648544	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036159.1|refseq:XP_011240840.1|refseq:XP_006510433.1|refseq:NP_001240826.1|refseq:NP_001240827.1|go:"GO:0005739"(mitochondrion)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005829"(cytosol)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0051341"(regulation of oxidoreductase activity)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR010418(ECSIT)|interpro:IPR029342|dip:DIP-33901N|reactome:R-MMU-166058|reactome:R-MMU-6799198|reactome:R-MMU-975138|reactome:R-MMU-975871	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:11847(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:OJosVT4SJO/B9WEMImjhVyFef3Q10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:F9220A4C56B778B8|rigid:vuhPXY9OzGnJftEFCLbDfTJvfVE	false	sufficient binding region:82-435	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62406-1	uniprotkb:P70196	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655574	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:14620(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:6E81FEEDBBC29CA5|rigid:NcTkqDpX3fuJqYwrtGBR9nF1dy0	false	sufficient binding region:473-677	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8N7N6	uniprotkb:P70196	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655634	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:55457(secondary-ac)	-	-	caution:The prey construct contains 5 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:1FAE3EDEE2E5B610|rigid:9gCKZQcgmYw5wMfxE1RsFjRypNM	false	sufficient binding region:1-247	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1R2	uniprotkb:P70196	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655664	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:6999(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:CD93ABEF50323E68|rigid:6pYWLd+M/1g8hbGjlJFBDa5xSdE	false	sufficient binding region:88-262	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P68040	uniprotkb:O88351	intact:EBI-296749|ensembl:ENSMUSP00000020640|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-1183965|uniprotkb:Q3THP0|uniprotkb:Q3THY7|uniprotkb:Q3TKQ0|uniprotkb:Q3TW88|uniprotkb:Q5NCC5|uniprotkb:Q5NCC6|uniprotkb:Q9CSQ0|uniprotkb:Q9ERM6	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:rack1_mouse(display_long)|uniprotkb:p205(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:12-3(gene name synonym)|uniprotkb:Gnb2-rs1(gene name synonym)|uniprotkb:Gnb2l1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655738	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P68040|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|go:"GO:0072344"(rescue of stalled ribosome)|ensembl:ENSMUSG00000020372(gene)|ensembl:ENSMUST00000020640(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0006412"(translation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|refseq:NP_032169.1	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:14441(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:515E0E3D632AFFD5|rigid:mBT8Z1z8uu7hetnSaKOmcFuXQWg	false	sufficient binding region:185-317	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P39429	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655778	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:53738(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:6F6ACB6CC8B63303|rigid:GKDnIiX2Gz1ltIGmNRWyCFYCe84	false	sufficient binding region:1-89	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P39429	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655798	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:53738(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:55D019B2CD6A80B0|rigid:GKDnIiX2Gz1ltIGmNRWyCFYCe84	false	sufficient binding region:1-104	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q921L5	uniprotkb:P39429	intact:EBI-646234|uniprotkb:Q3TF44|uniprotkb:Q9CSQ1|ensembl:ENSMUSP00000034460	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:cog2_mouse(display_long)|uniprotkb:Component of oligomeric Golgi complex 2(gene name synonym)|uniprotkb:Low density lipoprotein receptor defect C-complementing protein(gene name synonym)|uniprotkb:Cog2(gene name)|psi-mi:Cog2(display_short)|uniprotkb:Ldlc(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655808	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_084022.2|ensembl:ENSMUSG00000031979(gene)|ensembl:ENSMUST00000034460(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005795"(Golgi stack)|go:"GO:0005829"(cytosol)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0007030"(Golgi organization)|go:"GO:0015031"(protein transport)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0044877"(protein-containing complex binding)|interpro:IPR009316(COG complex component, COG2)|interpro:IPR024602|interpro:IPR024603|reactome:R-MMU-6807878|reactome:R-MMU-6811438|reactome:R-MMU-6811440	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:55451(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PLIDOyHvNxgpbjHK5frz4rHyOm810090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:A2412633D973475D|rigid:rRkzL2KN+Qnk4WYou8TttOKmH/U	false	sufficient binding region:70-161	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DBZ1	uniprotkb:P39429	intact:EBI-646241|uniprotkb:Q7TMH1|uniprotkb:Q8K1Z4|uniprotkb:Q9DA09	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:ikip_mouse(display_long)|uniprotkb:Ikbip(gene name)|psi-mi:Ikbip(display_short)|uniprotkb:Ikip(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655818	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081354.1|interpro:IPR024152|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:40169(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:o36OBaUjlBHBBjQM6NE7CZnuWYw10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:1549987B34422058|rigid:I0azdVwAtktHX/bfJV8u6EID7Vs	false	sufficient binding region:63-353	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QXA7	uniprotkb:Q60680-1	intact:EBI-646274|uniprotkb:Q80SV9|uniprotkb:Q9JHR8	intact:EBI-646260	psi-mi:tri44_mouse(display_long)|uniprotkb:Protein DIPB(gene name synonym)|uniprotkb:Protein Mc7(gene name synonym)|uniprotkb:Trim44(gene name)|psi-mi:Trim44(display_short)|uniprotkb:Dipb(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655828	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064663.2|interpro:IPR000315(Zinc finger, B-box)|go:"GO:0001961"(positive regulation of cytokine-mediated signaling pathway)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050821"(protein stabilization)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061944"(negative regulation of protein K48-linked ubiquitination)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:18475(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:tVgnE5tlE/bRrNuZIMsdnP2ydWc10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:F06C30678F685757|rigid:V+U0Xjx45m2t5pYH+fS/SY3cP7w	false	sufficient binding region:125-326	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80UK0	uniprotkb:Q60680-1	intact:EBI-646282|uniprotkb:Q3TLJ1|uniprotkb:Q810W3|uniprotkb:Q8CI09|ensembl:ENSMUSP00000099720|ensembl:ENSMUSP00000099721	intact:EBI-646260	psi-mi:sesd1_mouse(display_long)|uniprotkb:Sestd1(gene name)|psi-mi:Sestd1(display_short)|uniprotkb:Huntingtin-interacting protein-like protein(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655839	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_780674.1|refseq:XP_006499263.1|refseq:XP_006499264.1|refseq:XP_006499265.1|ensembl:ENSMUSG00000042272(gene)|ensembl:ENSMUST00000102659(transcript)|ensembl:ENSMUST00000102660(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:55488(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:6vT+co7M/u3no7+pSYJLpvahLEA10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:5E509F6B7B6CBBC9|rigid:XsH7EcJ//568YHeC1EhmdijLaf4	false	sufficient binding region:133-430	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60680-1	uniprotkb:P02535	intact:EBI-646260	intact:EBI-646288|uniprotkb:P08731|uniprotkb:Q8BUX3|uniprotkb:Q8BV09|uniprotkb:Q8BVU3|uniprotkb:Q9CXH6|uniprotkb:Q9JKB4	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:k1c10_mouse(display_long)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:56 kDa cytokeratin(gene name synonym)|uniprotkb:Keratin, type I cytoskeletal 59 kDa(gene name synonym)|uniprotkb:Krt10(gene name)|psi-mi:Krt10(display_short)|uniprotkb:Krt1-10(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655870	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646245(ikka_mouse)	refseq:NP_034790.2|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|mint:P02535|go:"GO:0003334"(keratinocyte development)|go:"GO:0005198"(structural molecule activity)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009986"(cell surface)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0071277"(cellular response to calcium ion)|reactome:R-MMU-6805567|reactome:R-MMU-6809371	afcs:14057(primary-reference)|afcs:50632(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rogid:/a3BFQt80FodMtWZiNH14TCythg10090	intact-crc:F617B4DDBF8FAEF4|rigid:MfvK/gLS2Gly9q7GkgYN+vtCZpM	false	sufficient binding region:400-650	sufficient binding region:143-316	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60680-1	uniprotkb:P02535	intact:EBI-646260	intact:EBI-646288|uniprotkb:P08731|uniprotkb:Q8BUX3|uniprotkb:Q8BV09|uniprotkb:Q8BVU3|uniprotkb:Q9CXH6|uniprotkb:Q9JKB4	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:k1c10_mouse(display_long)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:56 kDa cytokeratin(gene name synonym)|uniprotkb:Keratin, type I cytoskeletal 59 kDa(gene name synonym)|uniprotkb:Krt10(gene name)|psi-mi:Krt10(display_short)|uniprotkb:Krt1-10(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655880	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646245(ikka_mouse)	refseq:NP_034790.2|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|mint:P02535|go:"GO:0003334"(keratinocyte development)|go:"GO:0005198"(structural molecule activity)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009986"(cell surface)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0071277"(cellular response to calcium ion)|reactome:R-MMU-6805567|reactome:R-MMU-6809371	afcs:14057(primary-reference)|afcs:50632(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rogid:/a3BFQt80FodMtWZiNH14TCythg10090	intact-crc:EB2A077F68F4427F|rigid:MfvK/gLS2Gly9q7GkgYN+vtCZpM	false	sufficient binding region:400-650	sufficient binding region:143-333	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P02535	uniprotkb:Q60680-1	intact:EBI-646288|uniprotkb:P08731|uniprotkb:Q8BUX3|uniprotkb:Q8BV09|uniprotkb:Q8BVU3|uniprotkb:Q9CXH6|uniprotkb:Q9JKB4	intact:EBI-646260	psi-mi:k1c10_mouse(display_long)|uniprotkb:Cytokeratin-10(gene name synonym)|uniprotkb:56 kDa cytokeratin(gene name synonym)|uniprotkb:Keratin, type I cytoskeletal 59 kDa(gene name synonym)|uniprotkb:Krt10(gene name)|psi-mi:Krt10(display_short)|uniprotkb:Krt1-10(gene name synonym)|uniprotkb:Keratin-10(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655900	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034790.2|interpro:IPR018039|interpro:IPR002957(Keratin, type I)|interpro:IPR039008|mint:P02535|go:"GO:0003334"(keratinocyte development)|go:"GO:0005198"(structural molecule activity)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008544"(epidermis development)|go:"GO:0009986"(cell surface)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045095"(keratin filament)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045684"(positive regulation of epidermis development)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0071277"(cellular response to calcium ion)|reactome:R-MMU-6805567|reactome:R-MMU-6809371	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:50632(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/a3BFQt80FodMtWZiNH14TCythg10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:F6DDEFF1A27460D0|rigid:MfvK/gLS2Gly9q7GkgYN+vtCZpM	false	sufficient binding region:143-403	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K221	uniprotkb:Q60680-1	intact:EBI-646295|uniprotkb:Q3U3G6|uniprotkb:Q9D7M3|ensembl:ENSMUSP00000081840|ensembl:ENSMUSP00000120387	intact:EBI-646260	psi-mi:arfp2_mouse(display_long)|uniprotkb:ADP-ribosylation factor-interacting protein 2(gene name synonym)|uniprotkb:Arfip2(gene name)|psi-mi:Arfip2(display_short)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655920	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_084078.3|ensembl:ENSMUSG00000030881(gene)|ensembl:ENSMUST00000084782(transcript)|ensembl:ENSMUST00000131446(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006914"(autophagy)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0032588"(trans-Golgi network membrane)|go:"GO:0034315"(regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0042802"(identical protein binding)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0140090"(membrane curvature sensor activity)|interpro:IPR010504(Arfaptin-like)|interpro:IPR027267|interpro:IPR030798|mint:Q8K221|reactome:R-MMU-6811440	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:20660(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fRiest/QIBtqIWNUsPJKUJVNdAs10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:16B37EC973172B26|rigid:iCaf/CWTPVhC4cYIQBLwnFxypoA	false	sufficient binding region:6-290	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q68FF6	uniprotkb:Q60680-1	intact:EBI-645933|ensembl:ENSMUSP00000037210	intact:EBI-646260	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655931	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:53768(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:478E5114E7C6BD03|rigid:YjHq4gou5uOR0SGI7e9Et8uvLEY	false	sufficient binding region:431-702	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O09012	uniprotkb:Q60680-1	intact:EBI-646301|uniprotkb:Q3UM58|uniprotkb:Q8K2V5|uniprotkb:Q91YC7|ensembl:ENSMUSP00000049132|ensembl:ENSMUSP00000108151	intact:EBI-646260	psi-mi:pex5_mouse(display_long)|uniprotkb:Peroxisome receptor 1(gene name synonym)|uniprotkb:Peroxisomal C-terminal targeting signal import receptor(gene name synonym)|uniprotkb:PTS1-BP(gene name synonym)|uniprotkb:Peroxin-5(gene name synonym)|uniprotkb:PXR1P(gene name synonym)|uniprotkb:Pex5(gene name)|psi-mi:Pex5(display_short)|uniprotkb:Pxr1(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655951	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033021.2|refseq:NP_787947.1|refseq:NP_001264734.1|refseq:XP_006505821.1|refseq:XP_006505822.1|refseq:NP_001264259.1|refseq:XP_017176951.1|ensembl:ENSMUSG00000005069(gene)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006625"(protein targeting to peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007006"(mitochondrial membrane organization)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007031"(peroxisome organization)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016020"(membrane)|ensembl:ENSMUST00000035861(transcript)|ensembl:ENSMUST00000112532(transcript)|go:"GO:0016558"(protein import into peroxisome matrix)|go:"GO:0016560"(protein import into peroxisome matrix, docking)|go:"GO:0016561"(protein import into peroxisome matrix, translocation)|go:"GO:0019899"(enzyme binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021895"(cerebral cortex neuron differentiation)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033328"(peroxisome membrane targeting sequence binding)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0044255"(cellular lipid metabolic process)|go:"GO:0045046"(protein import into peroxisome membrane)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051262"(protein tetramerization)|go:"GO:0140311"(protein sequestering activity)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR024111|interpro:IPR024113|reactome:R-MMU-8866654|go:"GO:0000038"(very long-chain fatty acid metabolic process)|reactome:R-MMU-9033241|reactome:R-MMU-9664873|go:"GO:0000268"(peroxisome targeting sequence binding)|go:"GO:0001764"(neuron migration)|go:"GO:0005052"(peroxisome matrix targeting signal-1 binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:15136(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:GqfIILxRcIiR64Sc7t0ElWui3dw10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:B8D34343ED36135A|rigid:u+Pb+9LA42j0n5yv2sJ0putliyU	false	sufficient binding region:253-587	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99JG3	uniprotkb:Q60680-1	intact:EBI-646311|ensembl:ENSMUSP00000159441	intact:EBI-646260	psi-mi:anx13_mouse(display_long)|uniprotkb:Annexin-13(gene name synonym)|uniprotkb:Annexin XIII(gene name synonym)|uniprotkb:Anxa13(gene name)|psi-mi:Anxa13(display_short)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655961	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081487.1|ensembl:ENSMUSG00000055114(gene)|ensembl:ENSMUST00000227274(transcript)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:1901611"(phosphatidylglycerol binding)|interpro:IPR001464(Annexin)|interpro:IPR009166(Annexin, type XIII)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:55438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:G6kLdiQp0ADoF7kiV4h+jomoRxw10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:4FE5F9D24CC90EA5|rigid:Pws+SpSi/767HJkN5X9RLTozrX4	false	sufficient binding region:70-259	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3TVI8	uniprotkb:Q60680-1	intact:EBI-646316|uniprotkb:Q3TD91|uniprotkb:Q3TWL9|uniprotkb:Q8R319|ensembl:ENSMUSP00000040429	intact:EBI-646260	psi-mi:pbip1_mouse(display_long)|uniprotkb:Hpip(gene name synonym)|uniprotkb:Hematopoietic PBX-interacting protein(gene name synonym)|uniprotkb:Pbxip1(gene name)|psi-mi:Pbxip1(display_short)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655971	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666243.1|refseq:XP_006501416.1|ensembl:ENSMUSG00000042613(gene)|ensembl:ENSMUST00000038942(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005874"(microtubule)|go:"GO:0007155"(cell adhesion)|go:"GO:0010467"(gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0061975"(articular cartilage development)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1901148"(gene expression involved in extracellular matrix organization)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:2001106"(regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR033589|mint:Q3TVI8|go:"GO:0005737"(cytoplasm)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:55475(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:r8Dc/6AM2ygzAfQpzi1zK9vOvow10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:A3F6F7D00F231F21|rigid:X8JKm+9zyZ+Dtfw6Zdz3pMuG0Rk	false	sufficient binding region:318-528	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3TVI8	uniprotkb:Q60680-1	intact:EBI-646316|uniprotkb:Q3TD91|uniprotkb:Q3TWL9|uniprotkb:Q8R319|ensembl:ENSMUSP00000040429	intact:EBI-646260	psi-mi:pbip1_mouse(display_long)|uniprotkb:Hpip(gene name synonym)|uniprotkb:Hematopoietic PBX-interacting protein(gene name synonym)|uniprotkb:Pbxip1(gene name)|psi-mi:Pbxip1(display_short)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655981	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666243.1|refseq:XP_006501416.1|ensembl:ENSMUSG00000042613(gene)|ensembl:ENSMUST00000038942(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002532"(production of molecular mediator involved in inflammatory response)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005874"(microtubule)|go:"GO:0007155"(cell adhesion)|go:"GO:0010467"(gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030154"(cell differentiation)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0061975"(articular cartilage development)|go:"GO:0097043"(histone H3-K56 acetylation)|go:"GO:1901148"(gene expression involved in extracellular matrix organization)|go:"GO:1902732"(positive regulation of chondrocyte proliferation)|go:"GO:2001106"(regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR033589|mint:Q3TVI8|go:"GO:0005737"(cytoplasm)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:55475(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:r8Dc/6AM2ygzAfQpzi1zK9vOvow10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:633A537F999EAC0F|rigid:X8JKm+9zyZ+Dtfw6Zdz3pMuG0Rk	false	sufficient binding region:352-528	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BHB2	uniprotkb:P52332	intact:EBI-646336	intact:EBI-646320|uniprotkb:Q62126	psi-mi:q8bhb2_mouse(display_long)|uniprotkb:Ehmt1(gene name)|psi-mi:Ehmt1(display_short)	psi-mi:jak1_mouse(display_long)|uniprotkb:Janus kinase 1(gene name synonym)|uniprotkb:Jak1(gene name)|psi-mi:Jak1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655991	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR001214(SET)|refseq:NP_766133.2|interpro:IPR038035|interpro:IPR036770|go:"GO:0002039"(p53 binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0008168"(methyltransferase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016571"(histone methylation)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|interpro:IPR043550	dip:DIP-41965N|mint:P52332|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0034112"(positive regulation of homotypic cell-cell adhesion)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0038110"(interleukin-2-mediated signaling pathway)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046872"(metal ion binding)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:0150105"(protein localization to cell-cell junction)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:1904894"(positive regulation of receptor signaling pathway via STAT)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR020776|interpro:IPR035963|interpro:IPR036860|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|reactome:R-MMU-1059683|reactome:R-MMU-110056|reactome:R-MMU-112411|reactome:R-MMU-1169408|reactome:R-MMU-1266695|reactome:R-MMU-5673001|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-6788467|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8983432|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020591|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912526|reactome:R-MMU-912694|reactome:R-MMU-9674555|reactome:R-MMU-9705462	afcs:53734(primary-reference)|afcs:55483(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:262qLeGtqsBrknM2Kd3Vv4oNMwo10090	rogid:UIkyfJs6ggPxf4nXciyTLPqerSA10090	intact-crc:B7AEFB98A42D4F33|rigid:m8osXq879RCXVIQDA7HLO4ijx2w	false	sufficient binding region:385-752	sufficient binding region:200-450	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q76MZ3	uniprotkb:O88351	intact:EBI-400413|ensembl:ENSMUSP00000007708	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:2aaa_mouse(display_long)|uniprotkb:Ppp2r1a(gene name)|psi-mi:Ppp2r1a(display_short)|uniprotkb:PP2A subunit A isoform PR65-alpha(gene name synonym)|uniprotkb:PP2A subunit A isoform R1-alpha(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656002	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058587.1|go:"GO:0051306"(mitotic sister chromatid separation)|go:"GO:0051754"(meiotic sister chromatid cohesion, centromeric)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903538"(regulation of meiotic cell cycle process involved in oocyte maturation)|go:"GO:1990405"(protein antigen binding)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000357(HEAT)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR031090|mint:Q76MZ3|rcsb pdb:2IAE|rcsb pdb:2PF4|rcsb pdb:3FGA|rcsb pdb:6EF4|reactome:R-MMU-113501|reactome:R-MMU-1295596|reactome:R-MMU-141444|reactome:R-MMU-180024|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-2995383|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-389513|reactome:R-MMU-432142|reactome:R-MMU-4641262|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-5673000|reactome:R-MMU-5675221|reactome:R-MMU-6804757|reactome:R-MMU-6811558|reactome:R-MMU-68877|reactome:R-MMU-69231|reactome:R-MMU-69273|reactome:R-MMU-8854518|reactome:R-MMU-9648025|reactome:R-MMU-975957|ensembl:ENSMUSG00000007564(gene)|ensembl:ENSMUST00000007708(transcript)|go:"GO:0000159"(protein phosphatase type 2A complex)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0019888"(protein phosphatase regulator activity)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051232"(meiotic spindle elongation)|dip:DIP-29429N	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:17807(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0tnO11U1SNOOT46j23f7dim8O8k10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:26C4114413ACFAAA|rigid:07a7oppoLSd3QAqC07/GW3+KBBk	false	sufficient binding region:90-380	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64519	uniprotkb:O88351	intact:EBI-646349|uniprotkb:Q3UDD9|uniprotkb:Q6ZQA4|uniprotkb:Q7TQD4|ensembl:ENSMUSP00000065877	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:sdc3_mouse(display_long)|uniprotkb:Sdc3(gene name)|psi-mi:Sdc3(display_short)|uniprotkb:Kiaa0468(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656012	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035650.2|ensembl:ENSMUSG00000025743(gene)|ensembl:ENSMUST00000070478(transcript)|go:"GO:0005796"(Golgi lumen)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016477"(cell migration)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0044393"(microspike)|interpro:IPR001050(Syndecan)|interpro:IPR003585(Neurexin/syndecan/glycophorin C)|interpro:IPR027789|interpro:IPR030479|interpro:IPR031194|reactome:R-MMU-1971475|reactome:R-MMU-2022928|reactome:R-MMU-2024096|reactome:R-MMU-202733|reactome:R-MMU-3000170|reactome:R-MMU-975634|go:"GO:0030424"(axon)	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:16821(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jyjpF//3xglTlgDLkBdF8MoYQVA10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:2656BEAAA65E080B|rigid:WmWCPtU/EbDQ3ZUP06XYxr8Bdy0	false	sufficient binding region:246-422	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WV80	uniprotkb:O88351	intact:EBI-646356|uniprotkb:Q9EQZ9	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:snx1_mouse(display_long)|uniprotkb:Snx1(gene name)|psi-mi:Snx1(display_short)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656022	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR028660|refseq:NP_062701.2|interpro:IPR001683(Phox-like)|interpro:IPR005329(Sorting nexin, N-terminal)|interpro:IPR015404(Vps5 C terminal like)|interpro:IPR027267|interpro:IPR034901|mint:Q9WV80|interpro:IPR036871|go:"GO:0030905"(retromer, tubulation complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0031175"(neuron projection development)|go:"GO:0031623"(receptor internalization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034498"(early endosome to Golgi transport)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098793"(presynapse)|go:"GO:0098999"(extrinsic component of postsynaptic endosome membrane)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:1990460"(leptin receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0010008"(endosome membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030904"(retromer complex)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:18246(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Yf/oVE8cR+cYTTplNaxj/OwjMWg10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:342B883271994AFD|rigid:5emDb0sIk2xkDn6yIxrVWKYE8dA	false	sufficient binding region:251-466	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P30115	uniprotkb:O88351	intact:EBI-646363|uniprotkb:Q544Y6|ensembl:ENSMUSP00000027067|ensembl:ENSMUSP00000113262	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:gsta3_mouse(display_long)|uniprotkb:Glutathione S-transferase Yc(gene name synonym)|uniprotkb:Glutathione S-transferase Ya3(gene name synonym)|uniprotkb:GST class-alpha member 3(gene name synonym)|uniprotkb:Gsta3(gene name)|psi-mi:Gsta3(display_short)|uniprotkb:Gstyc(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656042	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070821.1|refseq:NP_034486.2|ensembl:ENSMUSG00000025934(gene)|ensembl:ENSMUST00000027067(transcript)|ensembl:ENSMUST00000121676(transcript)|go:"GO:0001657"(ureteric bud development)|go:"GO:0004364"(glutathione transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006805"(xenobiotic metabolic process)|go:"GO:0046223"(aflatoxin catabolic process)|interpro:IPR003080(Glutathione S-transferase, alpha class)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR004046(Glutathione S-transferase, C-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR036249|interpro:IPR036282	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:16114(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fveJcY64Rhu+N0PR6wKZ+ysfit410090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:B0FFCA67B19BCB79|rigid:IW7lCLfDHvrl7esRB+xgpwMPDXU	false	sufficient binding region:54-201	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BTZ7	uniprotkb:O88351	intact:EBI-646372|ensembl:ENSMUSP00000036898|ensembl:ENSMUSP00000107914	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:gmppb_mouse(display_long)|uniprotkb:GTP-mannose-1-phosphate guanylyltransferase beta(gene name synonym)|uniprotkb:GDP-mannose pyrophosphorylase B(gene name synonym)|uniprotkb:Gmppb(gene name)|psi-mi:Gmppb(display_short)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656052	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808578.1|refseq:XP_006511822.1|ensembl:ENSMUSG00000070284(gene)|ensembl:ENSMUST00000047947(transcript)|ensembl:ENSMUST00000112295(transcript)|go:"GO:0004475"(mannose-1-phosphate guanylyltransferase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0009298"(GDP-mannose biosynthetic process)|interpro:IPR001451(Bacterial transferase hexapeptide repeat)|interpro:IPR005835(Nucleotidyl transferase)|interpro:IPR018357|interpro:IPR029044|mint:Q8BTZ7	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:55490(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:aorXDYcAIT0rGtThN8Zm5knF73Q10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:71F401B73F2283C9|rigid:LzpAIgSFeRxCMTT6mC9UYUwj3v8	false	sufficient binding region:208-360	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97447-1	uniprotkb:P70196	intact:EBI-643787|ensembl:ENSMUSP00000023854|ensembl:ENSMUSP00000112295|intact:EBI-7485892|intact:MINT-1326991	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:p97447-1(display_long)|uniprotkb:KyoT1(isoform synonym)|uniprotkb:Fhl1(gene name)|psi-mi:Fhl1(display_short)|uniprotkb:KyoT(gene name synonym)|uniprotkb:RBP-associated molecule 14-1(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 1(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656062	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-643780(fhl1_mouse)|ensembl:ENSMUSG00000023092(gene)|ensembl:ENSMUST00000023854(transcript)|ensembl:ENSMUST00000116596(transcript)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:12021(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:aRTinreahM4oHvZJgLx9Wf0t89E10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:44FA4A93AAF8844B|rigid:pzy1rwfrwHJw5cZ2BCvx0zdfkrU	false	sufficient binding region:61-257	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VI36	uniprotkb:P70196	intact:EBI-983394|uniprotkb:Q3TB62|uniprotkb:Q3TZQ6|uniprotkb:Q8VI37	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:paxi_mouse(display_long)|uniprotkb:Pxn(gene name)|psi-mi:Pxn(display_short)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656072	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598676.2|go:"GO:0001725"(stress fiber)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005178"(integrin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0017166"(vinculin binding)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0038191"(neuropilin binding)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046872"(metal ion binding)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0051435"(BH4 domain binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:1901652"(response to peptide)|rcsb pdb:5W93|rcsb pdb:6JMU|reactome:R-MMU-180292|reactome:R-MMU-4420097|reactome:R-MMU-445355|reactome:R-MMU-446343|reactome:R-MMU-446388|reactome:R-MMU-8849471|refseq:NP_035353.1|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q8VI36|interpro:IPR001904(Paxillin)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:35467(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:x972uTduA/N0V3wYShfP138d6Sk10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:E9CBD445ACB5E683|rigid:o8f/Xsq48LDzalERBcscwA8sYpA	false	sufficient binding region:350-557	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:B7ZNY0	uniprotkb:Q60680-1	intact:EBI-659248	intact:EBI-646260	psi-mi:b7zny0_mouse(display_long)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688436	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR010630(Protein of unknown function DUF1220)|interpro:IPR012943(Spindle associated)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)	intact:EBI-646245(ikka_mouse)	afcs:55507(secondary-ac)|afcs:14057(primary-reference)|afcs:55507(primary-reference)	caution:"Protein [uniprotkb:B7ZNY0] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"	-	caution:"Protein [uniprotkb:B7ZNY0] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:eiXGlR7tV0/mwnWc7nDJyyvzwFI10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:4D7FE09580278730|rigid:BMBdsns7XMZ9sj9t5INqk8IJcL4	false	sufficient binding region:?-?	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60680-1	uniprotkb:B7ZNY0	intact:EBI-646260	intact:EBI-659248	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:b7zny0_mouse(display_long)|uniprotkb:Pde4dip(gene name)|psi-mi:Pde4dip(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688447	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646245(ikka_mouse)	interpro:IPR010630(Protein of unknown function DUF1220)|interpro:IPR012943(Spindle associated)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)	afcs:55507(secondary-ac)|afcs:14057(primary-reference)|afcs:55507(primary-reference)	-	caution:"Protein [uniprotkb:B7ZNY0] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"	caution:"Protein [uniprotkb:B7ZNY0] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	rogid:eiXGlR7tV0/mwnWc7nDJyyvzwFI10090	intact-crc:7B4132FD193F1521|rigid:BMBdsns7XMZ9sj9t5INqk8IJcL4	false	sufficient binding region:400-650	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:E9Q557	uniprotkb:Q60680-1	intact:EBI-688046|ensembl:ENSMUSP00000115062	intact:EBI-646260	psi-mi:desp_mouse(display_long)|uniprotkb:Dsp(gene name)|psi-mi:Dsp(display_short)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688470	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076331.2|ensembl:ENSMUSG00000054889(gene)|ensembl:ENSMUST00000124830(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0002934"(desmosome organization)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0030057"(desmosome)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0034332"(adherens junction organization)|go:"GO:0042060"(wound healing)|go:"GO:0043588"(skin development)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0086073"(bundle of His cell-Purkinje myocyte adhesion involved in cell communication)|go:"GO:0086091"(regulation of heart rate by cardiac conduction)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:0150105"(protein localization to cell-cell junction)|interpro:IPR001101(Plectin repeat)|interpro:IPR001452(Src homology-3)|interpro:IPR018159|interpro:IPR028462|interpro:IPR035915|interpro:IPR041573|interpro:IPR041615|interpro:IPR043197|mint:E9Q557|reactome:R-MMU-351906|reactome:R-MMU-6798695|reactome:R-MMU-6805567|reactome:R-MMU-6809371|reactome:R-MMU-9696264|reactome:R-MMU-9696273	intact:EBI-646245(ikka_mouse)	afcs:54904(secondary-ac)|afcs:14057(primary-reference)|afcs:54904(primary-reference)	comment:AfCS Y2H protein. Translated from nucleotide sequence.|comment:"Similar to DESP_HUMAN Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen) (95%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AQF1MrZZW8M5RfagBI7P4b3qQPA10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:B24039B1066721CF|rigid:nYahYPNxFzoyQo8XcInIL+lIqIc	false	sufficient binding region:219-362	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39429	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655554	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:16826(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:3AC57ECE31607BD4|rigid:zasCBbUD5WsoMLSoNC5925q7ak4	false	sufficient binding region:56-334	sufficient binding region:293-501	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656843	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 8 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:4E80633458E34E10|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:1-312	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C886	uniprotkb:P39428	intact:EBI-646708|uniprotkb:Q8R3H1|uniprotkb:A0A1W2P6Q7|uniprotkb:A0A1W2P7X5|ensembl:ENSMUSP00000151799	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:pkhn1_mouse(display_long)|uniprotkb:Plekhn1(gene name)|psi-mi:Plekhn1(display_short)|uniprotkb:Cardiolipin and phosphatidic acid-binding protein(gene name synonym)|uniprotkb:Clpabp(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656913	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000078485(gene)|ensembl:ENSMUST00000217885(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR042835	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58120(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2018/10/11	rogid:mIzWRQmmgEyEzjsKvhnwbO1Frgw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:CDAB95474401CACC|rigid:tO4nwY0LpWX+MNgkDcCadhFlT10	false	sufficient binding region:?-?	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C886	uniprotkb:P39428	intact:EBI-646708|uniprotkb:Q8R3H1|uniprotkb:A0A1W2P6Q7|uniprotkb:A0A1W2P7X5|ensembl:ENSMUSP00000151799	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:pkhn1_mouse(display_long)|uniprotkb:Plekhn1(gene name)|psi-mi:Plekhn1(display_short)|uniprotkb:Cardiolipin and phosphatidic acid-binding protein(gene name synonym)|uniprotkb:Clpabp(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656923	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000078485(gene)|ensembl:ENSMUST00000217885(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR042835	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58120(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2018/10/11	rogid:mIzWRQmmgEyEzjsKvhnwbO1Frgw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:6318A269C5BDEA52|rigid:tO4nwY0LpWX+MNgkDcCadhFlT10	false	sufficient binding region:?-?	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C886	uniprotkb:P39428	intact:EBI-646708|uniprotkb:Q8R3H1|uniprotkb:A0A1W2P6Q7|uniprotkb:A0A1W2P7X5|ensembl:ENSMUSP00000151799	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:pkhn1_mouse(display_long)|uniprotkb:Plekhn1(gene name)|psi-mi:Plekhn1(display_short)|uniprotkb:Cardiolipin and phosphatidic acid-binding protein(gene name synonym)|uniprotkb:Clpabp(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656953	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000078485(gene)|ensembl:ENSMUST00000217885(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR042835	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58120(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2018/10/11	rogid:mIzWRQmmgEyEzjsKvhnwbO1Frgw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:0279947E6683F26C|rigid:tO4nwY0LpWX+MNgkDcCadhFlT10	false	sufficient binding region:?-?	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q924A0	uniprotkb:P39428	intact:EBI-646713|uniprotkb:O70574|uniprotkb:Q91XP2|uniprotkb:Q91XP3|uniprotkb:Q91XP4|uniprotkb:Q924A1|uniprotkb:Q9Z0V3|uniprotkb:Q9Z0V4|uniprotkb:Q8C834	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:tf7l2_mouse(display_long)|uniprotkb:HMG box transcription factor 4(gene name synonym)|uniprotkb:T-cell-specific transcription factor 4(gene name synonym)|uniprotkb:Tcf7l2(gene name)|psi-mi:Tcf7l2(display_short)|uniprotkb:Tcf4(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657013	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001136393.1|refseq:NP_001136396.1|dip:DIP-40920N|refseq:NP_001136390.1|mint:Q924A0|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030282"(bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030538"(embryonic genitalia morphogenesis)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032350"(regulation of hormone metabolic process)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0043588"(skin development)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0048641"(regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0071664"(catenin-TCF7L2 complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR036910|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-4641265|reactome:R-MMU-8853884|reactome:R-MMU-8951430|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:15412(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sg7QuRHMz8m1+v07Fmk+iPachlw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:59587F382B2AB579|rigid:SAp2ddgMruSp2irgtdD9Vs+GqfY	false	sufficient binding region:90-325	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63085	uniprotkb:Q8CDB0	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657053	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	intact-crc:EE17B3EA3DD11994|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:1-358	sufficient binding region:1-412	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657094	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:7F33C55F0B64A333|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:135-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08605	uniprotkb:P63085	intact:EBI-646859	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk1_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 1(gene name synonym)|uniprotkb:Mknk1(gene name)|psi-mi:Mknk1(display_short)|uniprotkb:Mnk1(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657514	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272417.1|refseq:NP_067436.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0046777"(protein autophosphorylation)|reactome:R-MMU-1295596	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:12169(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:nQ9d4dPH4qSOOl8O0nNMUXa46/w10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:F62C822EBDC46BD4|rigid:GWjaCTbXKpqOv+Pjs9O0EwmzHUw	false	sufficient binding region:294-427	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z104	uniprotkb:P39428	intact:EBI-646920|uniprotkb:Q9NSF7|uniprotkb:Q9NSF8|ensembl:ENSMUSP00000020454|ensembl:ENSMUSP00000100960|ensembl:ENSMUSP00000100961|ensembl:ENSMUSP00000128807	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:hm20b_mouse(display_long)|uniprotkb:HMG box-containing protein 20B(gene name synonym)|uniprotkb:Structural DNA-binding protein BRAF35(gene name synonym)|uniprotkb:BRCA2-associated factor 35(gene name synonym)|uniprotkb:Hmg20b(gene name)|psi-mi:Hmg20b(display_short)|uniprotkb:Braf35(gene name synonym)|uniprotkb:Hmgx2(gene name synonym)|uniprotkb:Smarce1r(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657615	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156637.1|refseq:NP_001156638.1|refseq:NP_034570.1|ensembl:ENSMUSG00000020232(gene)|ensembl:ENSMUST00000020454(transcript)|ensembl:ENSMUST00000105323(transcript)|ensembl:ENSMUST00000105324(transcript)|ensembl:ENSMUST00000167481(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002111"(BRCA2-BRAF35 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|rcsb pdb:2CRJ|reactome:R-MMU-3214815|reactome:R-MMU-983231	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:23603(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FqfdR1RK6T2N0BYXOD5lfPay8AY10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:E786A17A72CC85FD|rigid:rmQtlbizNascaTRbPsASpl0MCXI	false	sufficient binding region:108-317	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R332-1	uniprotkb:P39428	intact:EBI-646962|ensembl:ENSMUSP00000038716	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:q8r332-1(display_long)|uniprotkb:Nup58(gene name)|psi-mi:Nup58(display_short)|uniprotkb:58 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin-like protein 1(gene name synonym)|uniprotkb:Nupl1(gene name synonym)|uniprotkb:p58(isoform synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657695	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646954(nupl1_mouse)|ensembl:ENSMUSG00000114797(gene)|ensembl:ENSMUST00000041905(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58144(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YLsFTqH5EgU83bQb2r7ap3NDQac10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:6947D9E6AB70898E|rigid:a7UIAoebyyB4QafaHfvo+kaNBJI	false	sufficient binding region:50-319	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6P1E1-1	uniprotkb:P39429	intact:EBI-647043|ensembl:ENSMUSP00000124863	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:q6p1e1-1(display_long)|uniprotkb:Zmiz1(gene name)|psi-mi:Zmiz1(display_short)|uniprotkb:Rai17(gene name synonym)|uniprotkb:Zimp10(gene name synonym)|uniprotkb:PIAS-like protein Zimp10(gene name synonym)|uniprotkb:Retinoic acid-induced protein 17(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657844	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-647033(zim10_mouse)|ensembl:ENSMUSG00000007817(gene)|ensembl:ENSMUST00000162645(transcript)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:58153(secondary-ac)	isoform-comment:No experimental confirmation available.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YDCZA1JO5KiYFqN/y8VMYNLfUTA10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:0AE3B1D6460DDFE0|rigid:Ia+xSY7xcEBa7c8d/WfFkZ3RGpM	false	sufficient binding region:830-1052	sufficient binding region:293-501	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62962	uniprotkb:P52633	intact:EBI-647096|uniprotkb:P10924|ensembl:ENSMUSP00000018437	intact:EBI-647085|uniprotkb:Q8R2F1|ensembl:ENSMUSP00000089708	psi-mi:prof1_mouse(display_long)|uniprotkb:Profilin I(gene name synonym)|uniprotkb:Pfn1(gene name)|psi-mi:Pfn1(display_short)	psi-mi:stat6_mouse(display_long)|uniprotkb:Stat6(gene name)|psi-mi:Stat6(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657924	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035202.1|dip:DIP-38075N|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032232"(negative regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0042989"(sequestering of actin monomers)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0050821"(protein stabilization)|go:"GO:0051054"(positive regulation of DNA metabolic process)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0060074"(synapse maturation)|go:"GO:0070064"(proline-rich region binding)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098688"(parallel fiber to Purkinje cell synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098885"(modification of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900029"(positive regulation of ruffle assembly)|interpro:IPR005454(Profilin, Mammalian)|interpro:IPR005455(Profilin, plant)|interpro:IPR027310|interpro:IPR029892|interpro:IPR036140|mint:P62962|reactome:R-MMU-376176|reactome:R-MMU-4086400|reactome:R-MMU-5663220|ensembl:ENSMUSG00000018293(gene)|ensembl:ENSMUST00000018437(transcript)|go:"GO:0000774"(adenyl-nucleotide exchange factor activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001843"(neural tube closure)|go:"GO:0003779"(actin binding)|go:"GO:0003785"(actin monomer binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)	refseq:NP_033310.2|dip:DIP-49680N|ensembl:ENSMUSG00000002147(gene)|ensembl:ENSMUST00000092074(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-3249367|reactome:R-MMU-6785807	afcs:15365(primary-reference)|afcs:11821(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:nzOTw5XdywGrh+fA9AInGIexyGk10090	rogid:m07k8wM7HDHszNbxbEL8Yu2oDYE10090	intact-crc:945A9587C0335211|rigid:soHo9vSiuVBzKY2KFxc926pSBf0	false	sufficient binding region:120-140	sufficient binding region:1-306	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z2X8	uniprotkb:O88351	intact:EBI-647110|uniprotkb:Q3U243|uniprotkb:Q3U8N7|uniprotkb:Q547S3|uniprotkb:Q6ZQI6|uniprotkb:Q8BQY3|ensembl:ENSMUSP00000062467|ensembl:ENSMUSP00000131029|ensembl:ENSMUSP00000141807|ensembl:ENSMUSP00000141840	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:keap1_mouse(display_long)|uniprotkb:Cytosolic inhibitor of Nrf2(gene name synonym)|uniprotkb:Keap1(gene name)|psi-mi:Keap1(display_short)|uniprotkb:Inrf2(gene name synonym)|uniprotkb:Kiaa0132(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657935	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103775.1|refseq:NP_001103776.1|refseq:NP_001103777.1|refseq:NP_057888.1|dip:DIP-49698N|ensembl:ENSMUSG00000003308(gene)|ensembl:ENSMUST00000049567(transcript)|ensembl:ENSMUST00000164812(transcript)|ensembl:ENSMUST00000193982(transcript)|ensembl:ENSMUST00000194542(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016234"(inclusion body)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030496"(midbody)|go:"GO:0031463"(Cul3-RING ubiquitin ligase complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0045604"(regulation of epidermal cell differentiation)|go:"GO:0071322"(cellular response to carbohydrate stimulus)|go:"GO:0071353"(cellular response to interleukin-4)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR006652(Kelch repeat type 1)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR015915(Kelch-type beta propeller)|interpro:IPR017096(Kelch-like protein, gigaxonin)|interpro:IPR030563|mint:Q9Z2X8|rcsb pdb:1X2J|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:2Z32|rcsb pdb:3ADE|rcsb pdb:3WDZ|rcsb pdb:3WN7|rcsb pdb:4ZY3|rcsb pdb:5CGJ|rcsb pdb:5FNQ|rcsb pdb:5FNR|rcsb pdb:5FNS|rcsb pdb:5FNT|rcsb pdb:5FNU|rcsb pdb:5FZJ|interpro:IPR011705(BTB/Kelch-associated)|rcsb pdb:5FZN|rcsb pdb:6QMC|rcsb pdb:6QMD|rcsb pdb:6QME|rcsb pdb:6QMJ|rcsb pdb:6QMK|rcsb pdb:6ZEW|rcsb pdb:6ZEY|rcsb pdb:6ZEZ|rcsb pdb:6ZF0|rcsb pdb:6ZF1|rcsb pdb:6ZF2|rcsb pdb:6ZF3|rcsb pdb:6ZF4|rcsb pdb:6ZF5|rcsb pdb:6ZF6|rcsb pdb:6ZF7|rcsb pdb:6ZF8|rcsb pdb:7C5E|rcsb pdb:7C60|reactome:R-MMU-5689880|reactome:R-MMU-8932339|reactome:R-MMU-8951664|reactome:R-MMU-983168|rcsb pdb:6ZEX	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:12089(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MDyGSGSBs4XgdCc2eeX6YCUdzmY10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:B4D97A9FFCB5A61C|rigid:SiGSHo5LJEOfcg9a48TrLueN/9A	false	sufficient binding region:348-624	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51807	uniprotkb:P47713	intact:EBI-642797|uniprotkb:Q5M8S6|ensembl:ENSMUSP00000137171|ensembl:ENSMUSP00000135978|ensembl:ENSMUSP00000090644|ensembl:ENSMUSP00000127990	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:dylt1_mouse(display_long)|uniprotkb:T-complex testis-specific protein 1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym)|uniprotkb:Tctex1(gene name synonym)|uniprotkb:Tctex-1(gene name synonym)|uniprotkb:Dynlt1(gene name)|psi-mi:Dynlt1(display_short)|uniprotkb:Activator of G-protein signaling 2(gene name synonym)|uniprotkb:Tctel1(gene name synonym)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657945	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001160099.1|refseq:NP_001160101.1|refseq:NP_001160102.1|refseq:NP_033368.1|ensembl:ENSMUST00000092966(transcript)|ensembl:ENSMUST00000169415(transcript)|ensembl:ENSMUST00000179554(transcript)|ensembl:ENSMUST00000179569(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0099503"(secretory vesicle)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|mint:P51807|rcsb pdb:5WI4|reactome:R-MMU-6798695|go:"GO:0030742"(GTP-dependent protein binding)|ensembl:ENSMUSG00000000579(gene)|ensembl:ENSMUSG00000092074(gene)|ensembl:ENSMUSG00000095677(gene)|ensembl:ENSMUSG00000096255(gene)|refseq:XP_017172676.1	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	afcs:15036(primary-reference)|afcs:9401(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fn6QN4J3aA++93iJwG3rFDjPBvM10090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:AD08508064745C55|rigid:2W5EFcjq57bxgyV4iL/qDYrMwqQ	false	sufficient binding region:1-113	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08709	uniprotkb:P47713	intact:EBI-444895|uniprotkb:Q91WT2|uniprotkb:Q9QWP4|uniprotkb:Q9QWW0	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:prdx6_mouse(display_long)|uniprotkb:Lysophosphatidylcholine acyltransferase 5(gene name synonym)|uniprotkb:Glutathione-dependent peroxiredoxin(gene name synonym)|uniprotkb:Antioxidant protein 2(gene name synonym)|uniprotkb:1-Cys peroxiredoxin(gene name synonym)|uniprotkb:Acidic calcium-independent phospholipase A2(gene name synonym)|uniprotkb:Non-selenium glutathione peroxidase(gene name synonym)|uniprotkb:Prdx6(gene name)|psi-mi:Prdx6(display_short)|uniprotkb:Aop2(gene name synonym)|uniprotkb:Ltw4(gene name synonym)|uniprotkb:Prdx5(gene name synonym)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657956	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031479.1|interpro:IPR000866(Alkyl hydroperoxide reductase/ Thiol specific antioxidant/ Mal allergen)|interpro:IPR024706|interpro:IPR019479|go:"GO:0000302"(response to reactive oxygen species)|go:"GO:0004601"(peroxidase activity)|go:"GO:0004602"(glutathione peroxidase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032060"(bleb assembly)|go:"GO:0042744"(hydrogen peroxide catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0047184"(1-acylglycerophosphocholine O-acyltransferase activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051920"(peroxiredoxin activity)|go:"GO:0098869"(cellular oxidant detoxification)|go:"GO:0102567"|go:"GO:0102568"|reactome:R-MMU-3299685|reactome:R-MMU-6798695|interpro:IPR013766(Thioredoxin domain)|mint:O08709|interpro:IPR036249	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	afcs:15036(primary-reference)|afcs:13821(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3Hnse2vkowtSGEobI2LJX6WrNl410090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:ABD2064F6A06C27C|rigid:yV5eOE5oYWYkdcALg0eM53/6xoc	false	sufficient binding region:3-178	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14211	uniprotkb:P70196	intact:EBI-644340|ensembl:ENSMUSP00000003912|uniprotkb:Q3TVD2	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:calr_mouse(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:Calr(gene name)|psi-mi:Calr(display_short)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657966	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031617.1|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0008284"(positive regulation of cell population proliferation)|interpro:IPR018124|mint:P14211|rcsb pdb:3O0V|rcsb pdb:3O0W|rcsb pdb:3O0X|rcsb pdb:3RG0|go:"GO:0009897"(external side of plasma membrane)|reactome:R-MMU-1236974|reactome:R-MMU-3000480|reactome:R-MMU-901042|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|ensembl:ENSMUSG00000003814(gene)|ensembl:ENSMUST00000003912(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|reactome:R-MMU-983170	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:13967(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/yN2nHI8x9rWoJO+b+2dYGxOgf010090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:12F7921D61A7D4A9|rigid:YPP1oM3nXQxPX4SijejfC0r7ELY	false	sufficient binding region:118-272	sufficient binding region:200-450	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61656	uniprotkb:O88351	intact:EBI-643076|uniprotkb:E9Q105	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:ddx5_mouse(display_long)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD1(gene name synonym)|uniprotkb:Ddx5(gene name)|psi-mi:Ddx5(display_short)|uniprotkb:Tnz2(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657977	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|reactome:R-MMU-3899300|reactome:R-MMU-72163|reactome:R-MMU-9018519|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009299"(mRNA transcription)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|dip:DIP-32293N|mint:Q61656	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:14179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:X5OQN/Gdq852njTrHnlDliAjrQY10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:1D412B808EDBF634|rigid:Obfm3XfCgV12ORF4tQeMDUpNSyc	false	sufficient binding region:319-614	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08856	uniprotkb:P42225	intact:EBI-647129|uniprotkb:Q3TXY9|ensembl:ENSMUSP00000091163	intact:EBI-647118	psi-mi:ell_mouse(display_long)|uniprotkb:Eleven-nineteen lysine-rich leukemia protein(gene name synonym)|uniprotkb:Ell(gene name)|psi-mi:Ell(display_short)	psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657987	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031950.2|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0008023"(transcription elongation factor complex)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019902"(phosphatase binding)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035327"|go:"GO:0035363"(histone locus body)|go:"GO:0042795"(snRNA transcription by RNA polymerase II)|go:"GO:0042796"(snRNA transcription by RNA polymerase III)|go:"GO:0045945"(positive regulation of transcription by RNA polymerase III)|interpro:IPR010844(Occludin and RNA polymerase II elongation factor ELL)|interpro:IPR019464|interpro:IPR031176|interpro:IPR031184|interpro:IPR036390|interpro:IPR042065|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-6796648|reactome:R-MMU-6807505|reactome:R-MMU-75955|ensembl:ENSMUSG00000070002(gene)|ensembl:ENSMUST00000093454(transcript)	dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295	afcs:15364(primary-reference)|afcs:14250(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4GxbT6h5yA/Vv63XVYRjP9nQYAE10090	rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090	intact-crc:46ABA683BCEE5ED5|rigid:euGwvUSYRYxrjuW8HYTbAdBrAD4	false	sufficient binding region:280-566	sufficient binding region:1-305	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37040	uniprotkb:P47713	intact:EBI-647134|ensembl:ENSMUSP00000005651	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:ncpr_mouse(display_long)|uniprotkb:Por(gene name)|psi-mi:Por(display_short)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657998	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032924.1|refseq:XP_006504461.1|refseq:XP_006504462.1|ensembl:ENSMUSG00000005514(gene)|ensembl:ENSMUST00000005651(transcript)|go:"GO:0003420"(regulation of growth plate cartilage chondrocyte proliferation)|go:"GO:0003958"(NADPH-hemoprotein reductase activity)|go:"GO:0004128"("cytochrome-b5 reductase activity, acting on NAD(P)H")|go:"GO:0005739"(mitochondrion)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0007584"(response to nutrient)|go:"GO:0008941"(nitric oxide dioxygenase activity)|go:"GO:0009055"(electron transfer activity)|go:"GO:0009437"(carnitine metabolic process)|go:"GO:0009725"(response to hormone)|go:"GO:0009812"(flavonoid metabolic process)|go:"GO:0010181"(FMN binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016491"(oxidoreductase activity)|go:"GO:0016709"("oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen")|go:"GO:0016787"(hydrolase activity)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0022900"(electron transport chain)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032770"(positive regulation of monooxygenase activity)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043602"(nitrate catabolic process)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0046210"(nitric oxide catabolic process)|go:"GO:0047726"(iron-cytochrome-c reductase activity)|go:"GO:0050660"(flavin adenine dinucleotide binding)|go:"GO:0050661"(NADP binding)|go:"GO:0060192"(negative regulation of lipase activity)|go:"GO:0070988"(demethylation)|go:"GO:0071372"(cellular response to follicle-stimulating hormone stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0090031"(positive regulation of steroid hormone biosynthetic process)|go:"GO:0090181"(regulation of cholesterol metabolic process)|go:"GO:0090346"(cellular organofluorine metabolic process)|interpro:IPR001094(Flavodoxin-like)|interpro:IPR001433("Oxidoreductase FAD/NAD(P)-binding")|interpro:IPR001709(Flavoprotein pyridine nucleotide cytochrome reductase)|interpro:IPR003097(FAD-binding, type 1)|interpro:IPR008254(Flavodoxin/nitric oxide synthase)|interpro:IPR017927|interpro:IPR017938|interpro:IPR023173|interpro:IPR023208|interpro:IPR029039|interpro:IPR039261|mint:P37040	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	afcs:15036(primary-reference)|afcs:15062(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:vAbEMJjVNV+LFIFubNftcQVxDHQ10090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:E5E0BB572DE07056|rigid:Hx4wZUEP7JE37dfYtfip+pjst+o	false	sufficient binding region:148-381	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70670	uniprotkb:P47713	intact:EBI-647147|uniprotkb:E9QMB1|ensembl:ENSMUSP00000089680	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:nacam_mouse(display_long)|uniprotkb:Gm1878(gene name synonym)|uniprotkb:Alpha-NAC, muscle-specific form(gene name synonym)|uniprotkb:Naca(gene name)|psi-mi:Naca(display_short)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658008	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106670.1|refseq:NP_038636.2|ensembl:ENSMUSG00000061315(gene)|ensembl:ENSMUST00000092048(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005854"(nascent polypeptide-associated complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051451"(myoblast migration)|interpro:IPR002715(Nascent polypeptide-associated complex NAC)|interpro:IPR016641(Nascent polypeptide-associated complex, alpha subunit)|interpro:IPR038187|interpro:IPR044034|mint:P70670	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	afcs:15036(primary-reference)|afcs:17311(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4QZh6JIwWgCTyZyvNxj5mmR6Bps10090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:64EEA95319E81802|rigid:ceGhPsl3d3LbP3UkLltqlsp8JUE	false	sufficient binding region:2034-2187	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JKF1	uniprotkb:P39428	intact:EBI-644633|ensembl:ENSMUSP00000128278|uniprotkb:G3UW45	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:iqga1_mouse(display_long)|uniprotkb:Iqgap1(gene name)|psi-mi:Iqgap1(display_short)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658018	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|ensembl:ENSMUSG00000030536(gene)|ensembl:ENSMUST00000167377(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0031252"(cell leading edge)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:Q9JKF1|reactome:R-MMU-373753|reactome:R-MMU-5626467|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013106|reactome:R-MMU-9013148|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-MMU-9013149|refseq:NP_057930.2|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:17695(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qjWT+er4GkLOlebk3zzRHh2Iqoo10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:B8A4163809032308|rigid:v2OsMFC31yi18YNAAzOpfVnA/T8	false	sufficient binding region:265-686	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QZ08	uniprotkb:O88351	intact:EBI-647173|ensembl:ENSMUSP00000042026	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:nagk_mouse(display_long)|uniprotkb:GlcNAc kinase(gene name synonym)|uniprotkb:Nagk(gene name)|psi-mi:Nagk(display_short)|uniprotkb:Gnk(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658028	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062415.1|ensembl:ENSMUSG00000034744(gene)|ensembl:ENSMUST00000037376(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0009384"(N-acylmannosamine kinase activity)|go:"GO:0019262"(N-acetylneuraminate catabolic process)|go:"GO:0045127"(N-acetylglucosamine kinase activity)|interpro:IPR002731(ATPase, BadF/BadG/BcrA/BcrD type)|interpro:IPR039758|interpro:IPR043129|reactome:R-MMU-446210|go:"GO:0006044"(N-acetylglucosamine metabolic process)	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:18125(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Zgfnld0VfSLTH+RsOAKYIlWhhv810090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:5DC9FB5401E7B538|rigid:iqoia42AWv+AJGQ1jorQg3vL8vo	false	sufficient binding region:135-343	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35450	uniprotkb:P39428	intact:EBI-647183|uniprotkb:Q3UKG5|ensembl:ENSMUSP00000037273	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:fkbpl_mouse(display_long)|uniprotkb:WAF-1/CIP1 stabilizing protein 39(gene name synonym)|uniprotkb:Fkbpl(gene name)|psi-mi:Fkbpl(display_short)|uniprotkb:Ng7(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658038	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_063926.1|refseq:XP_006524725.1|refseq:XP_006524724.1|ensembl:ENSMUSG00000033739(gene)|ensembl:ENSMUST00000036720(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:1905553"(regulation of blood vessel branching)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-MMU-8852276	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:18348(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:lelm7wPP/6eleIK01qv5KxnXO1M10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:58E2BB9F70AE0222|rigid:hV7WSwkJgBUVhSVWGQLc7IcPSiI	false	sufficient binding region:17-215	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91Y86	uniprotkb:P47713	intact:EBI-298784|ensembl:ENSMUSP00000107576	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:mk08_mouse(display_long)|uniprotkb:Mapk8(gene name)|psi-mi:Mapk8(display_short)|uniprotkb:Jnk1(gene name synonym)|uniprotkb:Prkm8(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK1(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 1(gene name synonym)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658048	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0009411"(response to UV)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019894"(kinesin binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031175"(neuron projection development)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031982"(vesicle)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034352"(positive regulation of glial cell apoptotic process)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035033"(histone deacetylase regulator activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0045202"(synapse)|go:"GO:0045664"(regulation of neuron differentiation)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046605"(regulation of centrosome cycle)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0048263"(determination of dorsal identity)|go:"GO:0048511"(rhythmic process)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0061833"(protein localization to tricellular tight junction)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097150"(neuronal stem cell population maintenance)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097441"(basal dendrite)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901485"(positive regulation of transcription factor catabolic process)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1904809"(regulation of dense core granule transport)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2001224"(positive regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008351(JNK MAP kinase)|interpro:IPR011009(Protein kinase-like)|mint:Q91Y86|reactome:R-MMU-139910|reactome:R-MMU-193648|reactome:R-MMU-2559580|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-450321|reactome:R-MMU-450341|reactome:R-MMU-5693565|reactome:R-MMU-9007892|reactome:R-MMU-111446|ensembl:ENSMUSG00000021936(gene)|ensembl:ENSMUST00000111945(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001764"(neuron migration)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002102"(podosome)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004705"(JUN kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0006970"(response to osmotic stress)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007254"(JNK cascade)|go:"GO:0007258"(JUN phosphorylation)|go:"GO:0009408"(response to heat)|refseq:NP_057909.1|dip:DIP-31075N	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	afcs:15036(primary-reference)|afcs:18702(secondary-ac)	-	-	caution:The prey construct contains 56 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PF6G6rHf26jidt+Mg3aFCvCm7pU10090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:5D1430EDBA10D57B|rigid:blhgELu363Araouc1y4EUkSZrek	false	sufficient binding region:1-348	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61817	uniprotkb:O88351	intact:EBI-647191|uniprotkb:Q99M21|uniprotkb:Q9CVK9	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:creb3_mouse(display_long)|uniprotkb:Transcription factor LZIP(gene name synonym)|uniprotkb:Creb3(gene name)|psi-mi:Creb3(display_short)|uniprotkb:Lzip(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658058	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR029808|reactome:R-MMU-8874211|go:"GO:0000139"(Golgi membrane)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006935"(chemotaxis)|go:"GO:0006990"(positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)|go:"GO:0008140"(cAMP response element binding protein binding)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016604"(nuclear body)|go:"GO:0019043"(establishment of viral latency)|go:"GO:0019046"(release from viral latency)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031726"(CCR1 chemokine receptor binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035497"(cAMP response element binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0090026"(positive regulation of monocyte chemotaxis)|go:"GO:0090045"(positive regulation of deacetylase activity)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0050930"(induction of positive chemotaxis)	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:18974(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hveVzIhuXJDz0QuD21sCGap7eYs10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:A5D0DE9EF8498B77|rigid:FQI0dULKZNzVhL1Ptkoip0RGydc	false	sufficient binding region:18-158	sufficient binding region:600-735	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BG51	uniprotkb:P39428	intact:EBI-647210|uniprotkb:Q3TJB7|uniprotkb:Q3UGU4|uniprotkb:Q5SYC3|uniprotkb:Q5SYC6|uniprotkb:Q8BLW3|uniprotkb:Q8BMH1|uniprotkb:Q922N0|uniprotkb:Q9D2R1|uniprotkb:Q9JKB9|ensembl:ENSMUSP00000090533	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:miro1_mouse(display_long)|uniprotkb:Ras homolog gene family member T1(gene name synonym)|uniprotkb:Rhot1(gene name)|psi-mi:Rhot1(display_short)|uniprotkb:Arht1(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658069	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156826.1|refseq:NP_001156827.1|refseq:NP_067511.4|refseq:XP_011247470.1|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0097345"(mitochondrial outer membrane permeabilization)|go:"GO:1902513"(regulation of organelle transport along microtubule)|interpro:IPR001806(Ras GTPase)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR011992(EF-Hand type)|interpro:IPR013566(EF hand associated, type-1)|interpro:IPR013567(EF hand associated, type-2)|interpro:IPR018247|interpro:IPR020860|interpro:IPR021181|interpro:IPR027417|interpro:IPR029506|reactome:R-MMU-5689880|reactome:R-MMU-9013425|go:"GO:0034640"(establishment of mitochondrion localization by microtubule attachment)|ensembl:ENSMUSG00000017686(gene)|ensembl:ENSMUST00000092857(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0010821"(regulation of mitochondrion organization)|go:"GO:0019725"(cellular homeostasis)|go:"GO:0031307"(integral component of mitochondrial outer membrane)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:55765(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:OFsiC3miDrI5fNs+k/a3VLtDvdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:39964458FA0A23A2|rigid:RNgzutnOmvPdkXt7FNJIFyv4h9A	false	sufficient binding region:420-592	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CPR7	uniprotkb:P39428	intact:EBI-647222|uniprotkb:Q8CBP5|ensembl:ENSMUSP00000029447	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:sike1_mouse(display_long)|uniprotkb:Sike1(gene name)|psi-mi:Sike1(display_short)|uniprotkb:Suppressor of IKK-epsilon(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658079	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079955.1|ensembl:ENSMUSG00000027854(gene)|ensembl:ENSMUST00000029447(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031267"(small GTPase binding)|interpro:IPR008555(Protein of unknown function DUF837)|mint:Q9CPR7	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:26639(secondary-ac)	-	-	caution:The prey construct contains 7 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TA3taHz18JNUWlHJNWTZZ9jkfNA10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:AC5BB1F7354ABCE0|rigid:qY5awGCBUSNhO6PM8CH2RxopMRY	false	sufficient binding region:1-207	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EP71	uniprotkb:P39428	intact:EBI-647227|uniprotkb:Q3URT3|uniprotkb:Q6ZPT6|ensembl:ENSMUSP00000087815|ensembl:ENSMUSP00000126325	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:rai14_mouse(display_long)|uniprotkb:Ankyrin repeat and coiled-coil structure-containing protein(gene name synonym)|uniprotkb:Retinoic acid-induced protein 14(gene name synonym)|uniprotkb:Novel retinal pigment epithelial cell protein(gene name synonym)|uniprotkb:p125(gene name synonym)|uniprotkb:Rai14(gene name)|psi-mi:Rai14(display_short)|uniprotkb:Kiaa1334(gene name synonym)|uniprotkb:Norpeg(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658089	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159880.1|refseq:NP_109615.1|refseq:XP_006520250.1|refseq:XP_006520251.1|refseq:XP_017172264.1|ensembl:ENSMUSG00000022246(gene)|ensembl:ENSMUST00000090339(transcript)|ensembl:ENSMUST00000169385(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0003779"(actin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005938"(cell cortex)|go:"GO:0007283"(spermatogenesis)|go:"GO:0030054"(cell junction)|go:"GO:0030154"(cell differentiation)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|interpro:IPR042420|mint:Q9EP71	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:30625(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:GjfwtzE2xp21+izEovwOKoUAlFY10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:158E51265B8BDEB0|rigid:G0SUbR/XQAiUlSe8w1jB5pDyZXg	false	sufficient binding region:880-979	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99M87	uniprotkb:P39428	intact:EBI-647233|uniprotkb:Q8BSM0|uniprotkb:Q99L09|uniprotkb:Q99P71|uniprotkb:Q99P76|uniprotkb:Q9CT11|uniprotkb:Q9DBJ7|uniprotkb:Q9DC44|ensembl:ENSMUSP00000053842	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:dnja3_mouse(display_long)|uniprotkb:Tumorous imaginal discs protein Tid56 homolog(gene name synonym)|uniprotkb:DnaJ protein Tid-1(gene name synonym)|uniprotkb:Dnaja3(gene name)|psi-mi:Dnaja3(display_short)|uniprotkb:Tid1(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658099	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001128584.1|refseq:NP_076135.3|mint:Q99M87|ensembl:ENSMUSG00000004069(gene)|ensembl:ENSMUST00000060067(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005133"(interferon-gamma receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006264"(mitochondrial DNA replication)|go:"GO:0006457"(protein folding)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006924"(activation-induced cell death of T cells)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0007569"(cell aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0030695"(GTPase regulator activity)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0034341"(response to interferon-gamma)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0060336"(negative regulation of interferon-gamma-mediated signaling pathway)|go:"GO:0071340"(skeletal muscle acetylcholine-gated channel clustering)|go:"GO:0106137"(IkappaB kinase complex binding)|interpro:IPR001305(Heat shock protein DnaJ, cysteine-rich region)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR002939(Chaperone DnaJ, C-terminal)|interpro:IPR008971(HSP40/DnaJ peptide-binding)|interpro:IPR012724(Chaperone DnaJ)|interpro:IPR018253|interpro:IPR036410|interpro:IPR036869	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:30731(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:dBJIJ2BY9vghCDt8+ooQWBFjsRs10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:EF9659DA0538F182|rigid:Qo4ZewxKAA/NypP69yCJIpGvtXE	false	sufficient binding region:152-430	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70585	uniprotkb:P39428	intact:EBI-349714|uniprotkb:O70563|uniprotkb:Q9CTZ1|uniprotkb:E9Q0F2|ensembl:ENSMUSP00000126194	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:dtnb_mouse(display_long)|uniprotkb:Dtnb(gene name)|psi-mi:Dtnb(display_short)|uniprotkb:Beta-dystrobrevin(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658109	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155937.1|ensembl:ENSMUSG00000071454(gene)|ensembl:ENSMUST00000164578(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009925"(basal plasma membrane)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0045202"(synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0099536"(synaptic signaling)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR011992(EF-Hand type)|interpro:IPR015153(EF-hand, region 1)|interpro:IPR015154(EF-hand, region 2)|interpro:IPR017432(Distrobrevin)|interpro:IPR043145	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:55765(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:5BxmvYreKnYpuU7c0saCR88ShhU10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:9860779FC6FF5373|rigid:mNPqNJDD8zM07QnkXj37EcjcwAU	false	sufficient binding region:299-495	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99K43	uniprotkb:P47713	intact:EBI-644779|uniprotkb:E9QPF0|uniprotkb:Q8CE25|ensembl:ENSMUSP00000043379	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:prc1_mouse(display_long)|uniprotkb:Prc1(gene name)|psi-mi:Prc1(display_short)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272926.1|reactome:R-MMU-5625900|interpro:IPR032921|ensembl:ENSMUSG00000038943(gene)|ensembl:ENSMUST00000047558(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019894"(kinesin binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030496"(midbody)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045171"(intercellular bridge)|go:"GO:0051256"(mitotic spindle midzone assembly)|go:"GO:0051301"(cell division)|go:"GO:0070938"(contractile ring)|go:"GO:1990023"(mitotic spindle midzone)|interpro:IPR007145(MAP65/ASE1)	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	afcs:15036(primary-reference)|afcs:40037(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Xu052dxwVt00LivzQdjuZFKxtEc10090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:32DEDC29EA4A0E55|rigid:cZWw59ArEt2Qp3iLvazxE2Qzxoc	false	sufficient binding region:312-458	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63085	uniprotkb:Q80WQ6	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	intact:EBI-647271|uniprotkb:Q3TBR9|uniprotkb:Q8K2I7|uniprotkb:Q8BJ70|ensembl:ENSMUSP00000099317|ensembl:ENSMUSP00000099318	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:rhdf2_mouse(display_long)|uniprotkb:Rhor(gene name synonym)|uniprotkb:Rhomboid veinlet-like protein 6(gene name synonym)|uniprotkb:Rhomboid-related protein(gene name synonym)|uniprotkb:Rhbdf2(gene name)|psi-mi:Rhbdf2(display_short)|uniprotkb:Rhbdl6(gene name synonym)|uniprotkb:Irhom2(gene name synonym)|uniprotkb:Rhomboid family member 2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658129	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	refseq:NP_001161152.1|refseq:NP_766160.2|dip:DIP-49675N|ensembl:ENSMUSG00000020806(gene)|ensembl:ENSMUST00000103028(transcript)|ensembl:ENSMUST00000103029(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0006508"(proteolysis)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042058"(regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0050708"(regulation of protein secretion)|go:"GO:0050709"(negative regulation of protein secretion)|interpro:IPR022241|interpro:IPR022764|interpro:IPR035952|mint:Q80WQ6	afcs:17112(primary-reference)|afcs:52568(secondary-ac)	-	-	caution:The prey construct contains 19 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rogid:BDn+DSx7oj0ArheaEAu65ab39/E10090	intact-crc:9DF52B6F57486558|rigid:QxbtaaR0l6tlUAS2ZYgVnZqzYWo	false	sufficient binding region:1-358	sufficient binding region:1-48	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C0D7-2	uniprotkb:P42225	intact:EBI-645612|ensembl:ENSMUSP00000032480	intact:EBI-647118	psi-mi:q8c0d7-2(display_long)|uniprotkb:Ing4(gene name)|psi-mi:Ing4(display_short)|uniprotkb:p29ING4(gene name synonym)|uniprotkb:mINGh-M(isoform synonym)	psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658139	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645598(ing4_mouse)|ensembl:ENSMUSG00000030330(gene)|ensembl:ENSMUST00000032480(transcript)	dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295	afcs:15364(primary-reference)|afcs:53140(secondary-ac)	isoform-comment:May be due to a competing donor splice site.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:zv972KDJy09rLn9CTrSNKrK/zDs10090	rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090	intact-crc:4868301B6AEADB00|rigid:s4xQaCy46z0e/NIJiIyg8uQKoLc	false	sufficient binding region:15-147	sufficient binding region:1-305	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VCY6	uniprotkb:P39428	intact:EBI-647277|uniprotkb:Q8CH76|ensembl:ENSMUSP00000046643|ensembl:ENSMUSP00000103876	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:utp6_mouse(display_long)|uniprotkb:Multiple hat domains protein(gene name synonym)|uniprotkb:Utp6(gene name)|psi-mi:Utp6(display_short)|uniprotkb:Mhat(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658159	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659075.1|ensembl:ENSMUSG00000035575(gene)|ensembl:ENSMUST00000043152(transcript)|ensembl:ENSMUST00000108241(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0030515"(snoRNA binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013949(U3 small nucleolar RNA-associated protein 6)|reactome:R-MMU-6791226	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:53840(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:v7FuWPMyUgoCDP2+gEtMUNl9esU10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:82C2765573925DA1|rigid:JdVUaY7buIGlfOzK0VoS3brfrj8	false	sufficient binding region:196-515	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80UK0	uniprotkb:Q80TJ1	intact:EBI-646282|uniprotkb:Q3TLJ1|uniprotkb:Q810W3|uniprotkb:Q8CI09|ensembl:ENSMUSP00000099720|ensembl:ENSMUSP00000099721	intact:EBI-647288|uniprotkb:E9QN90|uniprotkb:Q3TSP2|uniprotkb:Q61374|uniprotkb:Q6AXB4|uniprotkb:Q6PGF0|ensembl:ENSMUSP00000108277	psi-mi:sesd1_mouse(display_long)|uniprotkb:Sestd1(gene name)|psi-mi:Sestd1(display_short)|uniprotkb:Huntingtin-interacting protein-like protein(gene name synonym)	psi-mi:caps1_mouse(display_long)|uniprotkb:Calcium-dependent activator protein for secretion 1(gene name synonym)|uniprotkb:Cadps(gene name)|psi-mi:Cadps(display_short)|uniprotkb:Caps(gene name synonym)|uniprotkb:Caps1(gene name synonym)|uniprotkb:Kiaa1121(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658169	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_780674.1|refseq:XP_006499263.1|refseq:XP_006499264.1|refseq:XP_006499265.1|ensembl:ENSMUSG00000042272(gene)|ensembl:ENSMUST00000102659(transcript)|ensembl:ENSMUST00000102660(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:1904878"(negative regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)	refseq:NP_001036082.1|refseq:XP_006518098.1|refseq:NP_036191.2|ensembl:ENSMUSG00000054423(gene)|ensembl:ENSMUST00000112658(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0015031"(protein transport)|go:"GO:0016050"(vesicle organization)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0050432"(catecholamine secretion)|go:"GO:0098674"(extrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010439(Protein of unknown function DUF1041)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR033227|mint:Q80TJ1	afcs:17191(primary-reference)|afcs:55488(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:6vT+co7M/u3no7+pSYJLpvahLEA10090	rogid:ZvxZwrj+Y7S4PfEUFS4qF4AAPB410090	intact-crc:AE3B4A19AD2CD5DE|rigid:d4fswng4T6DUeoq/20KBQOoefeU	false	sufficient binding region:235-596	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6PDM1	uniprotkb:Q80TJ1	intact:EBI-647298|uniprotkb:A3KFP2|uniprotkb:A3KFP4|uniprotkb:Q27QB3|uniprotkb:Q3TTE5|uniprotkb:Q80XS0|uniprotkb:Q8BPN3|uniprotkb:Q9D5C9|uniprotkb:Q9CXF9|ensembl:ENSMUSP00000042792	intact:EBI-647288|uniprotkb:E9QN90|uniprotkb:Q3TSP2|uniprotkb:Q61374|uniprotkb:Q6AXB4|uniprotkb:Q6PGF0|ensembl:ENSMUSP00000108277	psi-mi:msl1_mouse(display_long)|uniprotkb:Male-specific lethal-1 homolog 1(gene name synonym)|uniprotkb:Hampin(gene name synonym)|uniprotkb:Msl1(gene name)|psi-mi:Msl1(display_short)|uniprotkb:Msl1l1(gene name synonym)|uniprotkb:Male-specific lethal 1-like 1(gene name synonym)	psi-mi:caps1_mouse(display_long)|uniprotkb:Calcium-dependent activator protein for secretion 1(gene name synonym)|uniprotkb:Cadps(gene name)|psi-mi:Cadps(display_short)|uniprotkb:Caps(gene name synonym)|uniprotkb:Caps1(gene name synonym)|uniprotkb:Kiaa1121(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658180	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082998.2|refseq:XP_006534414.1|refseq:XP_011247586.1|ensembl:ENSMUSG00000052915(gene)|ensembl:ENSMUST00000037915(transcript)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0016607"(nuclear speck)|go:"GO:0043984"(histone H4-K16 acetylation)|go:"GO:0072487"(MSL complex)|interpro:IPR026711|interpro:IPR029332|interpro:IPR031840|rcsb pdb:2Y0M|rcsb pdb:2Y0N|reactome:R-MMU-3214847	refseq:NP_001036082.1|refseq:XP_006518098.1|refseq:NP_036191.2|ensembl:ENSMUSG00000054423(gene)|ensembl:ENSMUST00000112658(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0015031"(protein transport)|go:"GO:0016050"(vesicle organization)|go:"GO:0016082"(synaptic vesicle priming)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031045"(dense core granule)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0045956"(positive regulation of calcium ion-dependent exocytosis)|go:"GO:0050432"(catecholamine secretion)|go:"GO:0098674"(extrinsic component of neuronal dense core vesicle membrane)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099525"(presynaptic dense core vesicle exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR010439(Protein of unknown function DUF1041)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014770(Munc13 homology 1)|interpro:IPR033227|mint:Q80TJ1	afcs:17191(primary-reference)|afcs:55586(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hDTSo9VwaBRE+xxSuqdxx6p1SjA10090	rogid:ZvxZwrj+Y7S4PfEUFS4qF4AAPB410090	intact-crc:EFB12FA85073B346|rigid:6ddEfNI63DG42SjWdPlMsw4YFiA	false	sufficient binding region:118-365	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ESK9	uniprotkb:P42225	intact:EBI-647302|uniprotkb:E9QLQ2|uniprotkb:Q3TXX2|uniprotkb:Q61384|uniprotkb:Q8BRY9|uniprotkb:Q9JK14|ensembl:ENSMUSP00000027040	intact:EBI-647118	psi-mi:rbcc1_mouse(display_long)|uniprotkb:Coiled-coil-forming protein 1(gene name synonym)|uniprotkb:LaXp180(gene name synonym)|uniprotkb:Rb1cc1(gene name)|psi-mi:Rb1cc1(display_short)|uniprotkb:Cc1(gene name synonym)|uniprotkb:Kiaa0203(gene name synonym)|uniprotkb:FAK family kinase-interacting protein of 200 kDa(gene name synonym)	psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658190	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033956.2|dip:DIP-49679N|ensembl:ENSMUSG00000025907(gene)|ensembl:ENSMUST00000027040(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000421"(autophagosome membrane)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0001889"(liver development)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0007049"(cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030242"(autophagy of peroxisome)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034045"(phagophore assembly site membrane)|go:"GO:0034727"(piecemeal microautophagy of the nucleus)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045793"(positive regulation of cell size)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061709"(reticulophagy)|go:"GO:0061723"(glycophagy)|go:"GO:1990316"(Atg1/ULK1 kinase complex)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR019460|interpro:IPR040040|mint:Q9ESK9|reactome:R-MMU-1632852	dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295	afcs:15364(primary-reference)|afcs:55633(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:DiOKxKS7K4NtKX4DqF9ZtpkcOcc10090	rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090	intact-crc:45206435A9E4A569|rigid:a8YG0l7WCjU9PMobRIQ5XDAqopI	false	sufficient binding region:1079-1224	sufficient binding region:1-305	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D2C7	uniprotkb:P52633	intact:EBI-647309|uniprotkb:Q3TX81|uniprotkb:Q8BFY4|ensembl:ENSMUSP00000023749|ensembl:ENSMUSP00000124651|ensembl:ENSMUSP00000125117|ensembl:ENSMUSP00000125318|ensembl:ENSMUSP00000125563	intact:EBI-647085|uniprotkb:Q8R2F1|ensembl:ENSMUSP00000089708	psi-mi:bi1_mouse(display_long)|uniprotkb:Testis-enhanced gene transcript protein(gene name synonym)|uniprotkb:Tmbim6(gene name)|psi-mi:Tmbim6(display_short)|uniprotkb:Tegt(gene name synonym)|uniprotkb:Transmembrane BAX inhibitor motif-containing protein 6(gene name synonym)	psi-mi:stat6_mouse(display_long)|uniprotkb:Stat6(gene name)|psi-mi:Stat6(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658200	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001164505.1|refseq:NP_001164506.1|refseq:NP_001164507.1|refseq:NP_080945.1|ensembl:ENSMUSG00000023010(gene)|ensembl:ENSMUST00000023749(transcript)|ensembl:ENSMUST00000159209(transcript)|ensembl:ENSMUST00000159531(transcript)|ensembl:ENSMUST00000160635(transcript)|ensembl:ENSMUST00000161250(transcript)|go:"GO:0002638"(negative regulation of immunoglobulin production)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006914"(autophagy)|go:"GO:0010523"(negative regulation of calcium ion transport into cytosol)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032469"(endoplasmic reticulum calcium ion homeostasis)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0034620"(cellular response to unfolded protein)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0060698"(endoribonuclease inhibitor activity)|go:"GO:0060702"(negative regulation of endoribonuclease activity)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:1902065"(response to L-glutamate)|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR006213(Bax inhibitor 1, conserved site)|interpro:IPR006214(Protein of unknown function UPF0005)	refseq:NP_033310.2|dip:DIP-49680N|ensembl:ENSMUSG00000002147(gene)|ensembl:ENSMUST00000092074(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002296"(T-helper 1 cell lineage commitment)|go:"GO:0002829"(negative regulation of type 2 immune response)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0007165"(signal transduction)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034097"(response to cytokine)|go:"GO:0035771"(interleukin-4-mediated signaling pathway)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048295"(positive regulation of isotype switching to IgE isotypes)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060443"(mammary gland morphogenesis)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902170"(cellular response to reactive nitrogen species)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR028187|interpro:IPR035857|interpro:IPR036535|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-3249367|reactome:R-MMU-6785807	afcs:15365(primary-reference)|afcs:58177(secondary-ac)	-	-	caution:The prey construct contains 21 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:l9ON9626P3EzmgZJwrGWhZmB3UI10090	rogid:m07k8wM7HDHszNbxbEL8Yu2oDYE10090	intact-crc:117610CC74F8F21B|rigid:uxEIC6GJ9LpJjBPpVrwcGNocP14	false	sufficient binding region:1-151	sufficient binding region:1-306	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D8F3	uniprotkb:P47713	intact:EBI-647317|uniprotkb:Q8CCV8|ensembl:ENSMUSP00000023220	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:s52a2_mouse(display_long)|uniprotkb:Slc52a2(gene name)|psi-mi:Slc52a2(display_short)|uniprotkb:Gpr172b(gene name synonym)|uniprotkb:Porcine endogenous retrovirus A receptor 2 homolog(gene name synonym)|uniprotkb:Protein GPR172B(gene name synonym)|uniprotkb:Rft1(gene name synonym)|uniprotkb:Riboflavin transporter 1(gene name synonym)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658210	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083919.1|refseq:XP_006521214.1|ensembl:ENSMUSG00000022560(gene)|ensembl:ENSMUST00000023220(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0032217"(riboflavin transmembrane transporter activity)|go:"GO:0032218"(riboflavin transport)|go:"GO:0062124"(4-hydroxybutyrate receptor activity)|interpro:IPR009357(Protein of unknown function DUF1011)|reactome:R-MMU-196843	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	afcs:15036(primary-reference)|afcs:58179(secondary-ac)	-	-	caution:The prey construct contains 79 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QJw3MITMN0JfezxDfptkrmdIk2M10090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:A16E3578B58A5AFD|rigid:LyYGUMQgsI4vnyIiv3+I0Bmmm/s	false	sufficient binding region:1-281	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99P91	uniprotkb:P47713	intact:EBI-647325|uniprotkb:Q3U3R9|uniprotkb:Q8BVV9|uniprotkb:Q8BXL4|uniprotkb:Q9QXA0|ensembl:ENSMUSP00000031840	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:gpnmb_mouse(display_long)|uniprotkb:Dendritic cell-associated transmembrane protein(gene name synonym)|uniprotkb:DC-HIL(gene name synonym)|uniprotkb:Gpnmb(gene name)|psi-mi:Gpnmb(display_short)|uniprotkb:Dchil(gene name synonym)|uniprotkb:Nmb(gene name synonym)|uniprotkb:Hgfin(gene name synonym)|uniprotkb:Osteoactivin(gene name synonym)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658221	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444340.3|ensembl:ENSMUSG00000029816(gene)|ensembl:ENSMUST00000031840(transcript)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005178"(integrin binding)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0007267"(cell-cell signaling)|go:"GO:0008201"(heparin binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030282"(bone mineralization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031954"(positive regulation of protein autophosphorylation)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033162"(melanosome membrane)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042130"(negative regulation of T cell proliferation)|go:"GO:0045545"(syndecan binding)|go:"GO:0048018"(receptor ligand activity)|go:"GO:0050868"(negative regulation of T cell activation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR000601(PKD)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR022409|interpro:IPR035986|reactome:R-MMU-8857538	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	afcs:15036(primary-reference)|afcs:58180(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:J7hQb32kcT8WIXorMpfWvA8+R3010090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:3AFD4EB79DE9422C|rigid:hfWe9lbOrnNP3kNYWWGwRCyEmMw	false	sufficient binding region:76-216	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BIJ7	uniprotkb:P42225	intact:EBI-647341|uniprotkb:Q8BKQ4|uniprotkb:Q8BL21|uniprotkb:Q9EPM6|ensembl:ENSMUSP00000020643	intact:EBI-647118	psi-mi:rufy1_mouse(display_long)|uniprotkb:Rab4-interacting protein(gene name synonym)|uniprotkb:Rufy1(gene name)|psi-mi:Rufy1(display_short)|uniprotkb:Rabip4(gene name synonym)	psi-mi:stat1_mouse(display_long)|uniprotkb:Stat1(gene name)|psi-mi:Stat1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658231	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766145.1|go:"GO:0046872"(metal ion binding)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR004012(RUN)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017455(Zinc finger, FYVE-related)|interpro:IPR037213|mint:Q8BIJ7|reactome:R-MMU-1660499|go:"GO:0043231"(intracellular membrane-bounded organelle)|ensembl:ENSMUSG00000020375(gene)|ensembl:ENSMUST00000020643(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0006897"(endocytosis)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008289"(lipid binding)|go:"GO:0015031"(protein transport)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)	dip:DIP-38739N|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007584"(response to nutrient)|go:"GO:0008015"(blood circulation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009617"(response to bacterium)|go:"GO:0010742"(macrophage derived foam cell differentiation)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0030424"(axon)|go:"GO:0005730"(nucleolus)|reactome:R-MMU-1059683|reactome:R-MMU-1169408|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6785807|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-909733|reactome:R-MMU-912694|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001937"(negative regulation of endothelial cell proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032727"(positive regulation of interferon-alpha production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034240"(negative regulation of macrophage fusion)|go:"GO:0034340"(response to type I interferon)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0035456"(response to interferon-beta)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042393"(histone binding)|go:"GO:0030425"(dendrite)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046725"(negative regulation by virus of viral protein levels in host cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051591"(response to cAMP)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072136"(metanephric mesenchymal cell proliferation involved in metanephros development)|go:"GO:0072162"(metanephric mesenchymal cell differentiation)|go:"GO:0072308"(negative regulation of metanephric nephron tubule epithelial cell differentiation)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022752|interpro:IPR035859|interpro:IPR036535|go:"GO:0051607"(defense response to virus)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0061326"(renal tubule development)|interpro:IPR036860|go:"GO:0070106"(interleukin-27-mediated signaling pathway)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|interpro:IPR038295	afcs:15364(primary-reference)|afcs:58181(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:9ro2MkObt9rpc4AOzvM0Q9hK4Co10090	rogid:0UU+GWFvWO4Uj//otV/IYgwShKg10090	intact-crc:0B1A329C1EABD756|rigid:Kr6LkLbwXPz6gZT5zu/B9QWOJRI	false	sufficient binding region:318-412	sufficient binding region:1-305	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q78XY9	uniprotkb:Q99N13	intact:EBI-646416	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	psi-mi:q78xy9_mouse(display_long)|uniprotkb:Ubb(gene name)|psi-mi:Ubb(display_short)	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656095	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029071|refseq:NP_035794.1|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR019956|refseq:NP_001300913.1|go:"GO:0005739"(mitochondrion)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0047497"(mitochondrion transport along microtubule)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0061136"(regulation of proteasomal protein catabolic process)|go:"GO:1901214"(regulation of neuron death)|go:"GO:1902255"(positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|mint:Q78XY9	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	afcs:24669(primary-reference)|afcs:16907(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Rx+/zmzxbnmSyVdMSIgp6JvjLzs10090	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	intact-crc:C6ACE52D894B6AA6|rigid:gIAn+w/it6YJ+0LTKJQXu00DhQ0	false	sufficient binding region:1-296	sufficient binding region:325-588	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60335	uniprotkb:Q99N13	intact:EBI-309059|ensembl:ENSMUSP00000054863	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	psi-mi:pcbp1_mouse(display_long)|uniprotkb:Pcbp1(gene name)|psi-mi:Pcbp1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656136	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035995.1|ensembl:ENSMUSG00000051695(gene)|ensembl:ENSMUST00000053015(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008494"(translation activator activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:P60335|reactome:R-MMU-72163|reactome:R-MMU-72203	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	afcs:24669(primary-reference)|afcs:18563(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:x72fawo4plQ+ipfqIoREIDHc2bA10090	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	intact-crc:2F11F16101F95C4F|rigid:6Do/QiYvF/IFJwzNpwI1kPm8vXI	false	sufficient binding region:77-356	sufficient binding region:325-588	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60335	uniprotkb:Q99N13	intact:EBI-309059|ensembl:ENSMUSP00000054863	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	psi-mi:pcbp1_mouse(display_long)|uniprotkb:Pcbp1(gene name)|psi-mi:Pcbp1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656146	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035995.1|ensembl:ENSMUSG00000051695(gene)|ensembl:ENSMUST00000053015(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008494"(translation activator activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:P60335|reactome:R-MMU-72163|reactome:R-MMU-72203	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	afcs:24669(primary-reference)|afcs:18563(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:x72fawo4plQ+ipfqIoREIDHc2bA10090	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	intact-crc:4B9BAA241C9F14C2|rigid:6Do/QiYvF/IFJwzNpwI1kPm8vXI	false	sufficient binding region:88-328	sufficient binding region:325-588	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60335	uniprotkb:Q99N13	intact:EBI-309059|ensembl:ENSMUSP00000054863	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	psi-mi:pcbp1_mouse(display_long)|uniprotkb:Pcbp1(gene name)|psi-mi:Pcbp1(display_short)|uniprotkb:Alpha-CP1(gene name synonym)|uniprotkb:Heterogeneous nuclear ribonucleoprotein E1(gene name synonym)	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656156	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035995.1|ensembl:ENSMUSG00000051695(gene)|ensembl:ENSMUST00000053015(transcript)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0008494"(translation activator activity)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0098847"(sequence-specific single stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:P60335|reactome:R-MMU-72163|reactome:R-MMU-72203	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	afcs:24669(primary-reference)|afcs:18563(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:x72fawo4plQ+ipfqIoREIDHc2bA10090	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	intact-crc:D740EAE78752C2CF|rigid:6Do/QiYvF/IFJwzNpwI1kPm8vXI	false	sufficient binding region:89-356	sufficient binding region:325-588	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VEF1	uniprotkb:Q8BSK8	intact:EBI-646433|uniprotkb:Q3U914|uniprotkb:Q3UD89|uniprotkb:Q69ZH2|uniprotkb:Q8BNF1|ensembl:ENSMUSP00000001280	intact:EBI-646423|uniprotkb:Q5SWG1|uniprotkb:Q8CHX0|ensembl:ENSMUSP00000119715	psi-mi:astra_mouse(display_long)|uniprotkb:Gramd1a(gene name)|psi-mi:Gramd1a(display_short)|uniprotkb:D7Bwg0611e(gene name synonym)|uniprotkb:Kiaa1533(gene name synonym)|uniprotkb:GRAM domain-containing protein 1A(gene name synonym)	psi-mi:ks6b1_mouse(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656176	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082174.3|ensembl:ENSMUSG00000001248(gene)|ensembl:ENSMUST00000001280(transcript)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0044232"(organelle membrane contact site)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|interpro:IPR004182(GRAM)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031968|rcsb pdb:6GQF|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)	refseq:NP_001107806.1|ensembl:ENSMUSG00000020516(gene)|ensembl:ENSMUST00000154617(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043201"(response to leucine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-166208	afcs:39296(primary-reference)|afcs:30565(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Rrr06ZfoV64oqeaGKiz8OxZQ4rI10090	rogid:uJPo7NVO75oHLm1/ZRG3W8uF//s10090	intact-crc:D1BBD72BD64EE49B|rigid:vI8JA0Q/sm4/MGCGvGSMGrk+LSw	false	sufficient binding region:1-228	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VEF1	uniprotkb:Q8BSK8	intact:EBI-646433|uniprotkb:Q3U914|uniprotkb:Q3UD89|uniprotkb:Q69ZH2|uniprotkb:Q8BNF1|ensembl:ENSMUSP00000001280	intact:EBI-646423|uniprotkb:Q5SWG1|uniprotkb:Q8CHX0|ensembl:ENSMUSP00000119715	psi-mi:astra_mouse(display_long)|uniprotkb:Gramd1a(gene name)|psi-mi:Gramd1a(display_short)|uniprotkb:D7Bwg0611e(gene name synonym)|uniprotkb:Kiaa1533(gene name synonym)|uniprotkb:GRAM domain-containing protein 1A(gene name synonym)	psi-mi:ks6b1_mouse(display_long)|uniprotkb:Ribosomal protein S6 kinase I(gene name synonym)|uniprotkb:p70 ribosomal S6 kinase alpha(gene name synonym)|uniprotkb:70 kDa ribosomal protein S6 kinase 1(gene name synonym)|uniprotkb:Rps6kb1(gene name)|psi-mi:Rps6kb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656187	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082174.3|ensembl:ENSMUSG00000001248(gene)|ensembl:ENSMUST00000001280(transcript)|go:"GO:0005776"(autophagosome)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006914"(autophagy)|go:"GO:0015485"(cholesterol binding)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031227"(intrinsic component of endoplasmic reticulum membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0044232"(organelle membrane contact site)|go:"GO:0071397"(cellular response to cholesterol)|go:"GO:0120020"(cholesterol transfer activity)|go:"GO:0140268"(endoplasmic reticulum-plasma membrane contact site)|interpro:IPR004182(GRAM)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR031968|rcsb pdb:6GQF|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)	refseq:NP_001107806.1|ensembl:ENSMUSG00000020516(gene)|ensembl:ENSMUST00000154617(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0001662"(behavioral fear response)|go:"GO:0003009"(skeletal muscle contraction)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004711"(ribosomal protein S6 kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007281"(germ cell development)|go:"GO:0007568"(aging)|go:"GO:0007584"(response to nutrient)|go:"GO:0007616"(long-term memory)|go:"GO:0009408"(response to heat)|go:"GO:0009611"(response to wounding)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009749"(response to glucose)|go:"GO:0009986"(cell surface)|go:"GO:0014732"(skeletal muscle atrophy)|go:"GO:0014878"(response to electrical stimulus involved in regulation of muscle adaptation)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0031667"(response to nutrient levels)|go:"GO:0031929"(TOR signaling)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033574"(response to testosterone)|go:"GO:0033762"(response to glucagon)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043201"(response to leucine)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0044539"(long-chain fatty acid import into cell)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046324"(regulation of glucose import)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048633"(positive regulation of skeletal muscle tissue growth)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016238(Ribosomal protein S6 kinase)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|reactome:R-MMU-166208	afcs:39296(primary-reference)|afcs:30565(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Rrr06ZfoV64oqeaGKiz8OxZQ4rI10090	rogid:uJPo7NVO75oHLm1/ZRG3W8uF//s10090	intact-crc:B7C92780B76CB70F|rigid:vI8JA0Q/sm4/MGCGvGSMGrk+LSw	false	sufficient binding region:47-494	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q9D0I9	afcs:35826	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688873	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	caution:The prey construct contains 3 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	intact-crc:F0349D3CD6C4E8F4|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:150-465	sufficient binding region:1-201	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0I9	intact:EBI-688018	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	afcs:35826	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688897	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	-	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:CCF5740B4D90D597|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:1-242	sufficient binding region:150-465	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0I9	intact:EBI-688018	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	afcs:35826	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688908	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	-	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:22C74B01754D50BB|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:2-143	sufficient binding region:150-465	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q9D0I9	afcs:35826	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688919	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	intact-crc:9E85B4E5AF139482|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:150-465	sufficient binding region:3-173	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q9D0I9	afcs:35826	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688930	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	intact-crc:62E392444B45D2F7|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:150-465	sufficient binding region:4-361	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q8BMK4	afcs:35826	intact:EBI-689057|uniprotkb:Q8BTK8|uniprotkb:Q8R3F2|uniprotkb:B2RRB4|ensembl:ENSMUSP00000050336|ensembl:ENSMUSP00000130304	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:ckap4_mouse(display_long)|uniprotkb:Ckap4(gene name)|psi-mi:Ckap4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-689064	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_780660.1|ensembl:ENSMUSG00000046841(gene)|ensembl:ENSMUST00000053871(transcript)|ensembl:ENSMUST00000167671(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR028428|mint:Q8BMK4|reactome:R-MMU-381426|reactome:R-MMU-5683826|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-9696264|reactome:R-MMU-9696270	afcs:35826(primary-reference)|afcs:35826(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:mmjhipfUChfmrPP+NpygwvlH2Zc10090	intact-crc:894D7E29CED84101|rigid:O4QdORy1iOcf9EmBCqNEsQKcdmY	false	sufficient binding region:150-465	sufficient binding region:106-543	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q8BMK4	afcs:35826	intact:EBI-689057|uniprotkb:Q8BTK8|uniprotkb:Q8R3F2|uniprotkb:B2RRB4|ensembl:ENSMUSP00000050336|ensembl:ENSMUSP00000130304	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:ckap4_mouse(display_long)|uniprotkb:Ckap4(gene name)|psi-mi:Ckap4(display_short)|uniprotkb:63-kDa cytoskeleton-linking membrane protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-689076	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_780660.1|ensembl:ENSMUSG00000046841(gene)|ensembl:ENSMUST00000053871(transcript)|ensembl:ENSMUST00000167671(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR028428|mint:Q8BMK4|reactome:R-MMU-381426|reactome:R-MMU-5683826|reactome:R-MMU-6798695|reactome:R-MMU-8957275|reactome:R-MMU-9696264|reactome:R-MMU-9696270	afcs:35826(primary-reference)|afcs:35826(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:mmjhipfUChfmrPP+NpygwvlH2Zc10090	intact-crc:E171FC92B8EFE4D1|rigid:O4QdORy1iOcf9EmBCqNEsQKcdmY	false	sufficient binding region:150-465	sufficient binding region:173-543	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:O08908	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651572	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:7796ED1F67FB66AE|rigid:1FBhY6eBXGI3TUXgmerzWs1aXe0	false	sufficient binding region:388-558	sufficient binding region:397-624	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:O08908	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651602	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:55A9AB82FF5C184F|rigid:1FBhY6eBXGI3TUXgmerzWs1aXe0	false	sufficient binding region:437-651	sufficient binding region:397-624	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26450	uniprotkb:Q62419	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-642935|ensembl:ENSMUSP00000003268	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:sh3g1_mouse(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3p8(gene name synonym)|uniprotkb:Sh3gl1(gene name)|psi-mi:Sh3gl1(display_short)|uniprotkb:Sh3d2b(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652291	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	refseq:NP_038692.1|ensembl:ENSMUSG00000003200(gene)|ensembl:ENSMUST00000003268(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q62419|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0099092"(postsynaptic density, intracellular component)	afcs:52679(primary-reference)|afcs:7176(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:IJQKTkGQglD3qko38oEulqRvyrQ10090	intact-crc:39DF92087F89A9F4|rigid:nyhCemQAK3i9lLZjxQ/4r5YElE4	false	sufficient binding region:1-251	sufficient binding region:178-368	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99N57	uniprotkb:P32883-2	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	intact:EBI-644285|uniprotkb:P08643-1|ensembl:ENSMUSP00000032399	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:p32883-2(display_long)|uniprotkb:Kras(gene name)|psi-mi:Kras(display_short)|uniprotkb:Kras2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652321	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	intact:EBI-644267(rask_mouse)|ensembl:ENSMUSG00000030265(gene)|ensembl:ENSMUST00000032399(transcript)	afcs:34274(primary-reference)|afcs:6639(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rogid:QQ2jCFyfJfOiwuQ4vrh9ZZ0C0y810090	intact-crc:80EECD77ADBA3E26|rigid:M2/qyH1XBR9A1IxxD7tEYky5Dj8	false	sufficient binding region:154-496	sufficient binding region:1-188	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26450	uniprotkb:P42337	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648690	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	afcs:15011(primary-reference)|afcs:52679(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:5977C79D459FCDA7|rigid:5MXFlA9qywcfB/6z9jJcOYhUONo	false	sufficient binding region:348-463	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23804	uniprotkb:Q8BWG8	intact:EBI-641788|uniprotkb:Q91XK7|uniprotkb:Q61040|uniprotkb:Q64330|ensembl:ENSMUSP00000020408	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:mdm2_mouse(display_long)|uniprotkb:p53-binding protein Mdm2(gene name synonym)|uniprotkb:Oncoprotein Mdm2(gene name synonym)|uniprotkb:Double minute 2 protein(gene name synonym)|uniprotkb:Mdm2(gene name)|psi-mi:Mdm2(display_short)|uniprotkb:RING-type E3 ubiquitin transferase Mdm2(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648741	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034916.1|dip:DIP-24174N|dip:DIP-24196N|refseq:NP_001275515.1|go:"GO:0016604"(nuclear body)|go:"GO:0016874"(ligase activity)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031648"(protein destabilization)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033612"(receptor serine/threonine kinase binding)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042176"(regulation of protein catabolic process)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042975"(peroxisome proliferator activated receptor binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043278"(response to morphine)|go:"GO:0043518"(negative regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045202"(synapse)|go:"GO:0045472"(response to ether)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0071301"(cellular response to vitamin B1)|go:"GO:0071312"(cellular response to alkaloid)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071391"(cellular response to estrogen stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0071494"(cellular response to UV-C)|go:"GO:0072717"(cellular response to actinomycin D)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901797"(negative regulation of signal transduction by p53 class mediator)|go:"GO:1902254"(negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:1904404"(response to formaldehyde)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990000"(amyloid fibril formation)|go:"GO:1990785"(response to water-immersion restraint stress)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR003121(SWIB/MDM2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015459(Ubiquitin-protein ligase E3 MDM2)|interpro:IPR016495(p53 negative regulator Mdm2/Mdm4)|interpro:IPR028340|interpro:IPR036443|interpro:IPR036885|go:"GO:0046827"(positive regulation of protein export from nucleus)|interpro:IPR044080|mint:P23804|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0051149"(positive regulation of muscle cell differentiation)|reactome:R-MMU-198323|reactome:R-MMU-2559580|reactome:R-MMU-2559585|reactome:R-MMU-3232142|reactome:R-MMU-399719|reactome:R-MMU-5689880|reactome:R-MMU-6804756|reactome:R-MMU-6804757|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0051726"(regulation of cell cycle)|reactome:R-MMU-6804760|reactome:R-MMU-69541|reactome:R-MMU-8941858|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0060411"(cardiac septum morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0061663"(NEDD8 ligase activity)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0070301"(cellular response to hydrogen peroxide)|ensembl:ENSMUSG00000020184(gene)|ensembl:ENSMUST00000020408(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001568"(blood vessel development)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0002039"(p53 binding)|go:"GO:0003170"(heart valve development)|go:"GO:0003181"(atrioventricular valve morphogenesis)|go:"GO:0003203"(endocardial cushion morphogenesis)|go:"GO:0003281"(ventricular septum development)|go:"GO:0003283"(atrial septum development)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006977"(DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest)|go:"GO:0007089"(traversing start control point of mitotic cell cycle)|go:"GO:0007507"(heart development)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010039"(response to iron ion)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|go:"GO:0010977"(negative regulation of neuron projection development)	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:7649(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:iXyzJNF2in1Qj+lXPmfZMlKWgls10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:1239C636CC212068|rigid:dUKLaSLCh8TD0vamqI1jX9ajpVI	false	sufficient binding region:183-489	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P09405	uniprotkb:Q9DC51	intact:EBI-641864|uniprotkb:Q548M9|uniprotkb:Q61991|uniprotkb:Q8BQD8|uniprotkb:Q99K50|ensembl:ENSMUSP00000027438	intact:EBI-641852|uniprotkb:Q3TGV1|uniprotkb:Q61019|uniprotkb:A2AE36|ensembl:ENSMUSP00000000001	psi-mi:nucl_mouse(display_long)|uniprotkb:Protein C23(gene name synonym)|uniprotkb:Ncl(gene name)|psi-mi:Ncl(display_short)|uniprotkb:Nuc(gene name synonym)	psi-mi:gnai3_mouse(display_long)|uniprotkb:"G(i) alpha-3"(gene name synonym)|uniprotkb:Gnai3(gene name)|psi-mi:Gnai3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648856	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035010.3|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0009986"(cell surface)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035368"(selenocysteine insertion sequence binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042162"(telomeric DNA binding)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043236"(laminin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044547"(DNA topoisomerase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:1901838"(positive regulation of transcription of nucleolar large rRNA by RNA polymerase I)|go:"GO:1990631"(ErbB-4 class receptor binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000232"(regulation of rRNA processing)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034230|interpro:IPR034233|interpro:IPR034234|interpro:IPR034235|interpro:IPR035979|mint:P09405|reactome:R-MMU-6791226|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000026234(gene)|ensembl:ENSMUST00000027438(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001650"(fibrillar center)|go:"GO:0001651"(dense fibrillar component)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005509"(calcium ion binding)	refseq:NP_034436.1|dip:DIP-49479N|ensembl:ENSMUSG00000000001(gene)|ensembl:ENSMUST00000000001(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005834"(heterotrimeric G-protein complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0007049"(cell cycle)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007188"(adenylate cyclase-modulating G protein-coupled receptor signaling pathway)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0007212"(dopamine receptor signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0016020"(membrane)|go:"GO:0016239"(positive regulation of macroautophagy)|go:"GO:0019003"(GDP binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0031821"(G protein-coupled serotonin receptor binding)|go:"GO:0032794"(GTPase activating protein binding)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033864"("positive regulation of NAD(P)H oxidase activity")|go:"GO:0042588"(zymogen granule)|go:"GO:0045121"(membrane raft)|go:"GO:0046039"(GTP metabolic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0051301"(cell division)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR001019("Guanine nucleotide binding protein (G-protein), alpha subunit")|interpro:IPR001408(G-protein alpha subunit, group I)|interpro:IPR011025(G protein alpha subunit, helical insertion)|interpro:IPR027417|mint:Q9DC51|rcsb pdb:3AB3|reactome:R-MMU-170670|reactome:R-MMU-392170|reactome:R-MMU-418594|reactome:R-MMU-9009391	afcs:21845(primary-reference)|afcs:7110(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:NkPifysnX6CafgtN+Ko/p4aBqGE10090	rogid:YJ4mEQU/4IYIxCCj7qgeNh92TNc10090	intact-crc:BC54E748A535C71A|rigid:SU6t2RQ0hFzKVIeIYWp/nZIkl/4	false	sufficient binding region:282-455	sufficient binding region:2-354	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:Q8CIH5	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649000	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:12352(secondary-ac)|afcs:22821(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:02B0EDE097099D23|rigid:aXgA30jhaawG0MyOtwxBf+Cj2NY	false	sufficient binding region:628-858	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BTM8	uniprotkb:Q8CIH5	intact:EBI-641991|uniprotkb:B7FAV0|uniprotkb:O54934|uniprotkb:Q7TQI1|uniprotkb:Q8BLK1|uniprotkb:Q8BTN7|uniprotkb:Q8VHX5|uniprotkb:Q8VHX8|uniprotkb:Q99KQ2|ensembl:ENSMUSP00000033699	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:flna_mouse(display_long)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)|uniprotkb:Flna(gene name)|psi-mi:Flna(display_short)|uniprotkb:Fln(gene name synonym)|uniprotkb:Fln1(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006527974.1|ensembl:ENSMUST00000033699(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|ensembl:ENSMUSG00000031328(gene)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0097368"(establishment of Sertoli cell barrier)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q8BTM8|reactome:R-MMU-114608|reactome:R-MMU-430116|reactome:R-MMU-446353|reactome:R-MMU-5627123	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:21359(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hp3whHs7nFMTtChpQ/KywkPalq810090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:813C37E7372D3267|rigid:g5G1GEKzMJq9mZe7ytj9rPc+kf0	false	sufficient binding region:1622-1979	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62158	uniprotkb:Q8CIH5	intact:EBI-642025|uniprotkb:Q62157|uniprotkb:Q8C2Q5|uniprotkb:Q99LK1|ensembl:ENSMUSP00000021761|ensembl:ENSMUSP00000152730	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:tri27_mouse(display_long)|uniprotkb:Ret finger protein(gene name synonym)|uniprotkb:Tripartite motif-containing protein 27(gene name synonym)|uniprotkb:Trim27(gene name)|psi-mi:Trim27(display_short)|uniprotkb:Rfp(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM27(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649142	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033080.2|refseq:XP_006516669.1|go:"GO:0019901"(protein kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045087"(innate immune response)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0016605"(PML body)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090281"(negative regulation of calcium ion import)|go:"GO:1902187"|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035791|interpro:IPR043136|mint:Q62158|reactome:R-MMU-3232142|reactome:R-MMU-8948751|ensembl:ENSMUSG00000021326(gene)|ensembl:ENSMUST00000021761(transcript)|ensembl:ENSMUST00000222544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001650"(fibrillar center)|go:"GO:0002820"(negative regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:15182(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ay3vOvfbC0rFrDbLB0NsvrT9eBw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:1EFF8C4DA4A6AEC1|rigid:MBpHTSCNayiq3GPwOCKBdGFtaKQ	false	sufficient binding region:1-142	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62158	uniprotkb:Q8CIH5	intact:EBI-642025|uniprotkb:Q62157|uniprotkb:Q8C2Q5|uniprotkb:Q99LK1|ensembl:ENSMUSP00000021761|ensembl:ENSMUSP00000152730	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:tri27_mouse(display_long)|uniprotkb:Ret finger protein(gene name synonym)|uniprotkb:Tripartite motif-containing protein 27(gene name synonym)|uniprotkb:Trim27(gene name)|psi-mi:Trim27(display_short)|uniprotkb:Rfp(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM27(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649162	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033080.2|refseq:XP_006516669.1|go:"GO:0019901"(protein kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045087"(innate immune response)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0016605"(PML body)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090281"(negative regulation of calcium ion import)|go:"GO:1902187"|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035791|interpro:IPR043136|mint:Q62158|reactome:R-MMU-3232142|reactome:R-MMU-8948751|ensembl:ENSMUSG00000021326(gene)|ensembl:ENSMUST00000021761(transcript)|ensembl:ENSMUST00000222544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001650"(fibrillar center)|go:"GO:0002820"(negative regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:15182(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ay3vOvfbC0rFrDbLB0NsvrT9eBw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:B1AFD517242C1074|rigid:MBpHTSCNayiq3GPwOCKBdGFtaKQ	false	sufficient binding region:1-158	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35658	uniprotkb:Q02956	intact:EBI-642072	intact:EBI-642057|uniprotkb:A2AD76|ensembl:ENSMUSP00000030922|intact:EBI-11573047|uniprotkb:Q3UHM5|uniprotkb:Q7TST7	psi-mi:c1qbp_mouse(display_long)|uniprotkb:Glycoprotein gC1qBP(gene name synonym)|uniprotkb:GC1q-R protein(gene name synonym)|uniprotkb:C1qbp(gene name)|psi-mi:C1qbp(display_short)|uniprotkb:Gc1qbp(gene name synonym)	psi-mi:kpcz_mouse(display_long)|uniprotkb:nPKC-zeta(gene name synonym)|uniprotkb:Prkcz(gene name)|psi-mi:Prkcz(display_short)|uniprotkb:Pkcz(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649204	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-140837|reactome:R-MMU-8980692|reactome:R-MMU-9013106|go:"GO:0001849"(complement component C1q complex binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005540"(hyaluronic acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006397"(mRNA processing)|go:"GO:0006915"(apoptotic process)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0008380"(RNA splicing)|go:"GO:0008494"(translation activator activity)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030449"(regulation of complement activation)|go:"GO:0030984"(kininogen binding)|go:"GO:0031690"(adrenergic receptor binding)|go:"GO:0032689"(negative regulation of interferon-gamma production)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0039534"(negative regulation of MDA-5 signaling pathway)|go:"GO:0039536"(negative regulation of RIG-I signaling pathway)|go:"GO:0042256"(mature ribosome assembly)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0070131"(positive regulation of mitochondrial translation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0097177"(mitochondrial ribosome binding)|go:"GO:0098793"(presynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901165"(positive regulation of trophoblast cell migration)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR003428(Mitochondrial glycoprotein)|interpro:IPR036561|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|dip:DIP-32249N	refseq:NP_032886.2|ensembl:ENSMUSG00000029053(gene)|ensembl:ENSMUST00000030922(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001725"(stress fiber)|go:"GO:0001954"(positive regulation of cell-matrix adhesion)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004697"(protein kinase C activity)|go:"GO:0004698"(calcium-dependent protein kinase C activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007616"(long-term memory)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016363"(nuclear matrix)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0031252"(cell leading edge)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031584"(activation of phospholipase D activity)|go:"GO:0016477"(cell migration)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045179"(apical cortex)|go:"GO:0045630"(positive regulation of T-helper 2 cell differentiation)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0031982"(vesicle)|go:"GO:0046872"(metal ion binding)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0032736"(positive regulation of interleukin-13 production)|go:"GO:0032753"(positive regulation of interleukin-4 production)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051222"(positive regulation of protein transport)|go:"GO:0032754"(positive regulation of interleukin-5 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0051346"(negative regulation of hydrolase activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043203"(axon hillock)|go:"GO:0060081"(membrane hyperpolarization)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070528"(protein kinase C signaling)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098696"(regulation of neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1990138"(neuron projection extension)|go:"GO:2000463"(positive regulation of excitatory postsynaptic potential)|go:"GO:2000553"(positive regulation of T-helper 2 cell cytokine production)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|go:"GO:0051899"(membrane depolarization)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR012233(Protein kinase C, zeta/iota)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR020454|interpro:IPR034877|mint:Q02956|reactome:R-MMU-2173791|reactome:R-MMU-5218921|reactome:R-MMU-5668599|reactome:R-MMU-9634635	afcs:15028(primary-reference)|afcs:13952(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:tPoLimqgF2SXeVXk7Z5rCQa+wTc10090	rogid:MYpdSZCYytyavjkeOeTCG21yEYg10090	intact-crc:A7923E396E516941|rigid:FjD2bJJRG6ZnO5sEagDO03ih+14	false	sufficient binding region:11-278	sufficient binding region:100-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49070	uniprotkb:E9PZQ0	intact:EBI-309114|uniprotkb:Q99JU5|ensembl:ENSMUSP00000021963	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:camlg_mouse(display_long)|uniprotkb:Camlg(gene name)|psi-mi:Camlg(display_short)|uniprotkb:Caml(gene name synonym)|uniprotkb:Calcium signal-modulating cyclophilin ligand(gene name synonym)|uniprotkb:Get2(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649214	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031622.2|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0043529"(GET complex)|go:"GO:0050821"(protein stabilization)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|interpro:IPR016719(Calcium signal-modulating cyclophilin ligand)|mint:P49070|ensembl:ENSMUSG00000021501(gene)|ensembl:ENSMUST00000021963(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001881"(receptor recycling)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:13971(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	caution:The prey construct contains 6 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:WhoJPAp432WGS6e6/wAiilnkJPM10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:70412BED42C5D9B6|rigid:zzEEgYClCcsYSld7uMEXh2EUmwg	false	sufficient binding region:1-148	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63260	uniprotkb:Q9Z2A0	intact:EBI-351301|uniprotkb:P02571|uniprotkb:P14104|uniprotkb:P99022|ensembl:ENSMUSP00000071486|ensembl:ENSMUSP00000101822	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:actg_mouse(display_long)|uniprotkb:Actg1(gene name)|psi-mi:Actg1(display_short)|uniprotkb:Actg(gene name synonym)|uniprotkb:Gamma-actin(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649360	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033739.1|reactome:R-MMU-190873|reactome:R-MMU-196025|reactome:R-MMU-2029482|reactome:R-MMU-3928662|reactome:R-MMU-418990|reactome:R-MMU-437239|reactome:R-MMU-4420097|reactome:R-MMU-445095|reactome:R-MMU-446353|reactome:R-MMU-5626467|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5674135|reactome:R-MMU-8856828|reactome:R-MMU-9013418|ensembl:ENSMUSG00000062825(gene)|ensembl:ENSMUST00000071555(transcript)|ensembl:ENSMUST00000106215(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001738"(morphogenesis of a polarized epithelium)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005522"(profilin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031941"(filamentous actin)|go:"GO:0042802"(identical protein binding)|go:"GO:0043034"(costamere)|go:"GO:0043209"(myelin sheath)|go:"GO:0043296"(apical junction complex)|go:"GO:0044305"(calyx of Held)|go:"GO:0045177"(apical part of cell)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048488"(synaptic vesicle endocytosis)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097433"(dense body)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098871"(postsynaptic actin cytoskeleton)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0099143"(presynaptic actin cytoskeleton)|go:"GO:0120192"(tight junction assembly)|go:"GO:0120220"(basal body patch)|go:"GO:0150111"(regulation of transepithelial transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|reactome:R-MMU-114608	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:15624(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:B2OOsE06lTfo90H3g8tlmUJQ7cY10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:93B42995831C6B30|rigid:LBTmBMx2FA77OvECZ2USWulBEaw	false	sufficient binding region:200-375	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99M51	uniprotkb:O88643	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	intact:EBI-457240	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649370	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	afcs:16524(primary-reference)|afcs:7326(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	intact-crc:8FA1C233A4D37331|rigid:91dEnwRmAN3eRGlnzzIAZVIPKuc	false	sufficient binding region:48-322	sufficient binding region:1-121	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11103	uniprotkb:Q9Z2A0	intact:EBI-642213|uniprotkb:Q9JLX4|uniprotkb:Q9QVQ3	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:parp1_mouse(display_long)|uniprotkb:Poly[ADP-ribose] synthase 1(gene name synonym)|uniprotkb:"NAD(+) ADP-ribosyltransferase 1"(gene name synonym)|uniprotkb:Parp1(gene name)|psi-mi:Parp1(display_short)|uniprotkb:Adprp(gene name synonym)|uniprotkb:Adprt(gene name synonym)|uniprotkb:Adprt1(gene name synonym)|uniprotkb:ADP-ribosyltransferase diphtheria toxin-like 1(gene name synonym)|uniprotkb:DNA ADP-ribosyltransferase PARP1(gene name synonym)|uniprotkb:Protein poly-ADP-ribosyltransferase PARP1(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649413	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1990966"(ATP generation from poly-ADP-D-ribose)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001170"(negative regulation of ATP biosynthetic process)|interpro:IPR001357(BRCT)|interpro:IPR001510(Zinc finger, PARP-type)|interpro:IPR004102("Poly(ADP-ribose) polymerase, regulatory region")|interpro:IPR008288(NAD+ ADP-ribosyltransferase)|interpro:IPR008893(WGR)|interpro:IPR012317("Poly(ADP-ribose) polymerase, catalytic region")|interpro:IPR012982(PADR1)|interpro:IPR036420|interpro:IPR036616|interpro:IPR036930|interpro:IPR036957|interpro:IPR038650|reactome:R-MMU-110362|reactome:R-MMU-2173795|reactome:R-MMU-3108214|reactome:R-MMU-5685939|reactome:R-MMU-5696394|reactome:R-MMU-5696395|reactome:R-MMU-5696400|go:"GO:1990404"(protein ADP-ribosylase activity)|go:"GO:0000723"(telomere maintenance)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003950"(NAD+ ADP-ribosyltransferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006259"(DNA metabolic process)|go:"GO:0006281"(DNA repair)|go:"GO:0006284"(base-excision repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006471"(protein ADP-ribosylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010990"(regulation of SMAD protein complex assembly)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0016604"(nuclear body)|go:"GO:0018312"(peptidyl-serine ADP-ribosylation)|go:"GO:0018424"(peptidyl-glutamic acid poly-ADP-ribosylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030592"(DNA ADP-ribosylation)|go:"GO:0032042"(mitochondrial DNA metabolic process)|go:"GO:0032700"(negative regulation of interleukin-17 production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036211"(protein modification process)|go:"GO:0040009"(regulation of growth rate)|go:"GO:0042769"(obsolete DNA damage response, detection of DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043504"(mitochondrial DNA repair)|go:"GO:0044030"(regulation of DNA methylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046332"(SMAD binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048148"(behavioral response to cocaine)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0050882"(voluntary musculoskeletal movement)|go:"GO:0051287"(NAD binding)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0034644"(cellular response to UV)|go:"GO:0070213"(protein auto-ADP-ribosylation)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0071451"(cellular response to superoxide)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090734"(site of DNA damage)|go:"GO:0140294"(NAD DNA ADP-ribosyltransferase activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903376"(regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway)|go:"GO:1903516"(regulation of single strand break repair)|go:"GO:1903518"(positive regulation of single strand break repair)|go:"GO:1903827"|go:"GO:1904357"(negative regulation of telomere maintenance via telomere lengthening)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904762"(positive regulation of myofibroblast differentiation)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:0070212"(protein poly-ADP-ribosylation)|mint:P11103|dip:DIP-39371N	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:13787(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZJY1aTtD8Cz198SVs9FDdUSli7s10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:B3A8CB1C6CCADBE7|rigid:qQ4jCyR1UIxClESXU3lnAhF3H8E	false	sufficient binding region:93-263	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08863	uniprotkb:Q9Z2A0	intact:EBI-642236|uniprotkb:E9QLX3	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:birc3_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:Birc3(gene name)|psi-mi:Birc3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649444	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031490.2|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|mint:O08863|dip:DIP-43742N	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:13827(secondary-ac)	-	-	caution:The prey construct contains 61 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rPZRfzbIHpwQop1BRwyZl+TfhUg10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:8C00C2A9A9B11743|rigid:W2n0+oS1zwM1fbxAx3oychhc4bs	false	sufficient binding region:1-503	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P56480	uniprotkb:Q9Z2A0	intact:EBI-299482|ensembl:ENSMUSP00000026459|uniprotkb:Q0QEP4|uniprotkb:Q3TFD7|uniprotkb:Q3TIP9|uniprotkb:Q3TK44|uniprotkb:Q3TWD5|uniprotkb:Q3TX28|uniprotkb:Q3U6U4|uniprotkb:Q3U774|uniprotkb:Q3UB69|uniprotkb:Q3UF69|uniprotkb:Q8CI65|uniprotkb:Q8VEJ5|uniprotkb:Q9CTI7|uniprotkb:Q9CWX7	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:atpb_mouse(display_long)|uniprotkb:Atp5f1b(gene name)|psi-mi:Atp5f1b(display_short)|uniprotkb:ATP synthase F1 subunit beta(gene name synonym)|uniprotkb:Atp5b(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649455	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR024034|interpro:IPR027417|interpro:IPR036121|mint:P56480|reactome:R-MMU-1268020|reactome:R-MMU-163210|reactome:R-MMU-8949613|interpro:IPR020003|ensembl:ENSMUSG00000025393(gene)|ensembl:ENSMUST00000026459(transcript)|go:"GO:0000275"("mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)")|go:"GO:0001525"(angiogenesis)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005753"(mitochondrial proton-transporting ATP synthase complex)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006933"(negative regulation of cell adhesion involved in substrate-bound cell migration)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0030228"(lipoprotein particle receptor activity)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042645"(mitochondrial nucleoid)|go:"GO:0042776"(mitochondrial ATP synthesis coupled proton transport)|go:"GO:0043209"(myelin sheath)|go:"GO:0043531"(ADP binding)|go:"GO:0043532"(angiostatin binding)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045121"(membrane raft)|go:"GO:0045259"(proton-transporting ATP synthase complex)|go:"GO:0045261"("proton-transporting ATP synthase complex, catalytic core F(1)")|go:"GO:0046034"(ATP metabolic process)|go:"GO:0046933"(proton-transporting ATP synthase activity, rotational mechanism)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0098761"(cellular response to interleukin-7)|go:"GO:1902600"(proton transmembrane transport)|interpro:IPR000194(ATPase, F1/V1/A1 complex, alpha/beta subunit, nucleotide-binding)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004100(ATPase, F1/V1/A1 complex, alpha/beta subunit, N-terminal)|interpro:IPR005722(ATPase, F1 complex, beta subunit)|go:"GO:0005524"(ATP binding)|refseq:NP_058054.2	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:17732(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ihjn7GQ1ZSBfGcfwEAYSiCIuq+410090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:F2CD268BBEA2940A|rigid:QePIuNnNyWU3VsDBtJuaTAYwCWA	false	sufficient binding region:180-458	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUA3	uniprotkb:P35991	intact:EBI-642245|uniprotkb:Q3TNA9|uniprotkb:Q3U4P1|uniprotkb:Q3U7G4|uniprotkb:Q4KUG1|uniprotkb:Q543K8|uniprotkb:Q8C5I6|uniprotkb:Q9JI86|ensembl:ENSMUSP00000117030	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:pfkap_mouse(display_long)|uniprotkb:Phosphohexokinase(gene name synonym)|uniprotkb:Phosphofructo-1-kinase isozyme C(gene name synonym)|uniprotkb:Pfkp(gene name)|psi-mi:Pfkp(display_short)|uniprotkb:Pfkc(gene name synonym)|uniprotkb:6-phosphofructokinase type C(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649465	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062677.1|ensembl:ENSMUSG00000021196(gene)|ensembl:ENSMUST00000138703(transcript)|go:"GO:0003872"(6-phosphofructokinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005945"(6-phosphofructokinase complex)|go:"GO:0006002"(fructose 6-phosphate metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0016020"(membrane)|go:"GO:0016208"(AMP binding)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048029"(monosaccharide binding)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061621"(canonical glycolysis)|go:"GO:0070095"(fructose-6-phosphate binding)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR000023(Phosphofructokinase)|interpro:IPR009161(6-phosphofructokinase, eukaryotic type)|interpro:IPR015912(Phosphofructokinase, conserved site)|interpro:IPR022953|interpro:IPR035966|interpro:IPR041914|mint:Q9WUA3|reactome:R-MMU-70171|go:"GO:0042802"(identical protein binding)|refseq:NP_001278000.1	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:18223(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Dz8hYnA4o2kETOSclerHtt7l/b810090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:2975A98D2AA71899|rigid:Bwmx7fqeb9g5t7Pt5OliIbaP1Kc	false	sufficient binding region:134-478	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62261	uniprotkb:Q8CIH5	intact:EBI-397843|ensembl:ENSMUSP00000006629|ensembl:ENSMUSP00000011877|uniprotkb:A2AFU1|uniprotkb:Q3TEM7|uniprotkb:Q5SQL8|uniprotkb:Q5SQL9|uniprotkb:Q9QWJ7	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:sptb2_mouse(display_long)|uniprotkb:Sptbn1(gene name)|psi-mi:Sptbn1(display_short)|uniprotkb:Spnb-2(gene name synonym)|uniprotkb:Spnb2(gene name synonym)|uniprotkb:Sptb2(gene name synonym)|uniprotkb:Beta-II spectrin(gene name synonym)|uniprotkb:Fodrin beta chain(gene name synonym)|uniprotkb:Embryonic liver fodrin(gene name synonym)|uniprotkb:Elf(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649486	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020315(gene)|ensembl:ENSMUST00000006629(transcript)|ensembl:ENSMUST00000011877(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0003779"(actin binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007009"(plasma membrane organization)|go:"GO:0007182"(common-partner SMAD protein phosphorylation)|go:"GO:0008091"(spectrin)|go:"GO:0012505"(endomembrane system)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030506"(ankyrin binding)|go:"GO:0030673"(axolemma)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031430"(M band)|go:"GO:0032437"(cuticular plate)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051693"(actin filament capping)|go:"GO:0060390"(regulation of SMAD protein signal transduction)|go:"GO:0071709"(membrane assembly)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001605(Spectrin/pleckstrin-like)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016343(Spectrin, beta subunit)|interpro:IPR018159|interpro:IPR036872|interpro:IPR041681|mint:Q62261|rcsb pdb:1BTN|rcsb pdb:1MPH|rcsb pdb:6M3P|reactome:R-MMU-375165|reactome:R-MMU-445095|reactome:R-MMU-5673001|reactome:R-MMU-6807878|reactome:R-MMU-9013420|reactome:R-MMU-9013424|refseq:NP_033286.2|refseq:NP_787030.2|refseq:XP_006514662.1|refseq:XP_006514663.1|dip:DIP-31558N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:15343(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:N6xVFU+ocY6PXsIz5ZIsA05bGPs10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:3974A8E0B8303C37|rigid:buLbLnYvTix20EkWFMjDitqC2L4	false	sufficient binding region:1677-1802	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97303	uniprotkb:Q8CIH5	intact:EBI-642285|uniprotkb:A2ANU9|ensembl:ENSMUSP00000103815|ensembl:ENSMUSP00000131592|uniprotkb:A2ANU8|uniprotkb:A2RRI0	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:bach2_mouse(display_long)|uniprotkb:BTB and CNC homolog 2(gene name synonym)|uniprotkb:Bach2(gene name)|psi-mi:Bach2(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649507	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103131.1|ensembl:ENSMUSG00000040270(gene)|ensembl:ENSMUST00000108180(transcript)|ensembl:ENSMUST00000171600(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0051170"(import into nucleus)|go:"GO:0090721"(primary adaptive immune response involving T cells and B cells)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR011333(BTB/POZ fold)|refseq:XP_006537630.1|refseq:XP_011248211.1|interpro:IPR043321	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:13906(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jsYGN0dWZMyO7x+pYzr22Qb9KLY10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:2E5597F270AE0F75|rigid:PHJt95cNvgtztURe0DXmDmnwF2g	false	sufficient binding region:417-661	sufficient binding region:631-740	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O55029	uniprotkb:Q99N72	intact:EBI-642302|uniprotkb:Q3U5Z9|ensembl:ENSMUSP00000035033	intact:EBI-641874	psi-mi:copb2_mouse(display_long)|uniprotkb:Beta'-coat protein(gene name synonym)|uniprotkb:p102(gene name synonym)|uniprotkb:Copb2(gene name)|psi-mi:Copb2(display_short)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649540	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056642.1|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-MMU-6807878|reactome:R-MMU-6811434|ensembl:ENSMUSG00000032458(gene)|ensembl:ENSMUST00000035033(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:1901998"(toxin transport)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016453(Coatomer, beta' subunit)|interpro:IPR020472|interpro:IPR036322|mint:O55029|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:23263(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:gNG1OpF+jXIVk7jLKcvbyd13VW810090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:0A6EC6B82F36D3F5|rigid:iy45bMSVaqNAyXpbTzM+XuUAw1A	false	sufficient binding region:393-785	sufficient binding region:325-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P39054-2	uniprotkb:E9PZQ0	intact:EBI-642353|ensembl:ENSMUSP00000088616	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:p39054-2(display_long)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym)|uniprotkb:Dynamin UDNM(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649560	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-642337(dyn2_mouse)|ensembl:ENSMUSG00000033335(gene)|ensembl:ENSMUST00000091087(transcript)	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:14203(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:erJ4QqPwOjhyjX7e5ST4NEus3lo10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:1FCB7E50038D00C9|rigid:zul69TL3aF2bRS61MdsYjpwuZBQ	false	sufficient binding region:757-866	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QWH1	uniprotkb:Q8CIH5	intact:EBI-642357|uniprotkb:O88463|uniprotkb:Q8K5D9|uniprotkb:B1AS98|uniprotkb:B1ASA4|ensembl:ENSMUSP00000030588|ensembl:ENSMUSP00000101690	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:phc2_mouse(display_long)|uniprotkb:p36(gene name synonym)|uniprotkb:Early development regulatory protein 2(gene name synonym)|uniprotkb:Phc2(gene name)|psi-mi:Phc2(display_short)|uniprotkb:Edr2(gene name synonym)|uniprotkb:Ph2(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001182012.1|refseq:NP_001182059.1|refseq:NP_061244.1|refseq:XP_006503300.1|refseq:XP_006503301.1|ensembl:ENSMUSG00000028796(gene)|ensembl:ENSMUST00000030588(transcript)|ensembl:ENSMUST00000106080(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008270"(zinc ion binding)|go:"GO:0031519"(PcG protein complex)|go:"GO:0035102"(PRC1 complex)|go:"GO:0042393"(histone binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR012313(Zinc finger, FCS-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR038603|mint:Q9QWH1|rcsb pdb:2NA1|reactome:R-MMU-2559580|reactome:R-MMU-3108214|reactome:R-MMU-3899300|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-8939243|reactome:R-MMU-8943724|refseq:XP_017175809.1	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:17940(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:nNgSS7uHUP3sCDlztQJqi2zl2EU10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:503754628F4AFFD8|rigid:K9jLbxTcqpKbtzy6I8fq//gXYgA	false	sufficient binding region:537-850	sufficient binding region:631-740	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6ZWY7	uniprotkb:Q9Z2A0	intact:EBI-642366	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:q6zwy7_mouse(display_long)|uniprotkb:Pfdn5(gene name)|psi-mi:Pfdn5(display_short)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649580	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011599(Prefoldin alpha subunit)|interpro:IPR004127(Prefoldin alpha-like)|interpro:IPR009053(Prefoldin)|go:"GO:0006457"(protein folding)|go:"GO:0016272"(prefoldin complex)|go:"GO:0051082"(unfolded protein binding)	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:18452(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MZBKee80rxzmT5Rr8Xk4zP1B0WU10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:65E63684556E8D32|rigid:j3GAYIRwwHk7tU+pD+b5NQhjOSw	false	sufficient binding region:21-160	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BU11	uniprotkb:Q8CIH5	intact:EBI-642377|uniprotkb:Q3UGN7|uniprotkb:Q80UI2|uniprotkb:Q99PN9|uniprotkb:Q9CS16|ensembl:ENSMUSP00000022766	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:tox4_mouse(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:Tox4(gene name)|psi-mi:Tox4(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649590	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075923.2|ensembl:ENSMUSG00000016831(gene)|ensembl:ENSMUST00000022766(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:Q8BU11	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:24561(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:kKlAMyudBIO92oXcn2QcaRHOruw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:5C744A347EC824CB|rigid:L6ucU+GbVY86mi0utdu+/gNSwcc	false	sufficient binding region:105-373	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P62631	uniprotkb:P35991	intact:EBI-642385|uniprotkb:P27706|ensembl:ENSMUSP00000054556	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:ef1a2_mouse(display_long)|uniprotkb:Eukaryotic elongation factor 1 A-2(gene name synonym)|uniprotkb:Statin-S1(gene name synonym)|uniprotkb:Eef1a2(gene name)|psi-mi:Eef1a2(display_short)|uniprotkb:Eef1al(gene name synonym)|uniprotkb:Stn(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649601	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031932.1|go:"GO:0003746"(translation elongation factor activity)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005853"(eukaryotic translation elongation factor 1 complex)|go:"GO:0006412"(translation)|go:"GO:0006414"(translational elongation)|go:"GO:0010035"(response to inorganic substance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045202"(synapse)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0090218"(positive regulation of lipid kinase activity)|interpro:IPR000795(Protein synthesis factor, GTP-binding)|interpro:IPR004160(Translation elongation factor EFTu/EF1A, C-terminal)|interpro:IPR004161(Translation elongation factor EFTu/EF1A, domain 2)|interpro:IPR004539(Translation elongation factor EF1A, eukaryotic and archaeal)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR009001(Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal)|interpro:IPR027417|interpro:IPR031157|mint:P62631|ensembl:ENSMUSG00000016349(gene)|ensembl:ENSMUST00000055990(transcript)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:14234(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:5Wr8A9JfvVaH+KRGc6VSnF2rkYE10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:5D8D3FE11F11ECB5|rigid:7ShpvqYV0FoLSGUrt5YOh2DrsIM	false	sufficient binding region:205-462	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PJ2	uniprotkb:Q61210	intact:EBI-642435|uniprotkb:Q3U2G3|uniprotkb:Q8C508|uniprotkb:Q8C700|uniprotkb:Q8CGI2|uniprotkb:Q99PQ4|ensembl:ENSMUSP00000026008	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:trim8_mouse(display_long)|uniprotkb:RING finger protein 27(gene name synonym)|uniprotkb:Glioblastoma-expressed RING finger protein(gene name synonym)|uniprotkb:Trim8(gene name)|psi-mi:Trim8(display_short)|uniprotkb:Gerp(gene name synonym)|uniprotkb:Rnf27(gene name synonym)|uniprotkb:Tripartite motif-containing protein 8(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM8(gene name synonym)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649675	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_444330.2|ensembl:ENSMUSG00000025034(gene)|ensembl:ENSMUST00000026008(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0016605"(PML body)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046597"(negative regulation of viral entry into host cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1902187"|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:23008(secondary-ac)	-	-	caution:The prey construct contains 7 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:tea7MMgl82scqZYdNsiCcPJ4U1g10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:276795C6A9C97572|rigid:Uk0IKDqYOYGsGUvX5vApI9AChoI	false	sufficient binding region:1-266	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:Q8BWG8	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649719	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:1A4A56C7A820ABEC|rigid:jbF69OubAfrWvihbeLD0WRdjIUw	false	sufficient binding region:88-280	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:Q8BWG8	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649759	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:DB41751D963D8B59|rigid:jbF69OubAfrWvihbeLD0WRdjIUw	false	sufficient binding region:171-280	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:Q8CIH5	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649769	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:AF1FB232C0139E74|rigid:hh2AAYtiPtg8XHG9benb824gNIw	false	sufficient binding region:170-280	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JKY5	uniprotkb:Q61210	intact:EBI-642457|uniprotkb:Q3UJ14|ensembl:ENSMUSP00000000939	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:hip1r_mouse(display_long)|uniprotkb:Hip1r(gene name)|psi-mi:Hip1r(display_short)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649779	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659507.3|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0061024"(membrane organization)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|mint:Q9JKY5|reactome:R-MMU-432722|reactome:R-MMU-8856828|ensembl:ENSMUSG00000000915(gene)|ensembl:ENSMUST00000000939(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:7715(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:IpLk7O7ZLqC+jq27bna4y8VwO1I10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:FB691F65934C2523|rigid:UIkNWXk1N5VvUGB8MZwz4z+187w	false	sufficient binding region:440-997	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JKY5	uniprotkb:Q61210	intact:EBI-642457|uniprotkb:Q3UJ14|ensembl:ENSMUSP00000000939	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:hip1r_mouse(display_long)|uniprotkb:Hip1r(gene name)|psi-mi:Hip1r(display_short)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649789	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659507.3|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048268"(clathrin coat assembly)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0055123"(digestive system development)|go:"GO:0060453"(regulation of gastric acid secretion)|go:"GO:0061024"(membrane organization)|go:"GO:0080025"(phosphatidylinositol-3,5-bisphosphate binding)|go:"GO:0097060"(synaptic membrane)|go:"GO:1901030"(positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway)|go:"GO:1905445"(positive regulation of clathrin coat assembly)|go:"GO:2000369"(regulation of clathrin-dependent endocytosis)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000588"(positive regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR002558(I/LWEQ)|interpro:IPR008942(ENTH/VHS)|interpro:IPR011417(ANTH)|interpro:IPR013809(Epsin-like, N-terminal)|interpro:IPR030224|interpro:IPR030555|interpro:IPR032422|interpro:IPR035964|mint:Q9JKY5|reactome:R-MMU-432722|reactome:R-MMU-8856828|ensembl:ENSMUSG00000000915(gene)|ensembl:ENSMUST00000000939(transcript)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0003779"(actin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005938"(cell cortex)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030276"(clathrin binding)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030837"(negative regulation of actin filament polymerization)|go:"GO:0032051"(clathrin light chain binding)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034316"(negative regulation of Arp2/3 complex-mediated actin nucleation)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:7715(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:IpLk7O7ZLqC+jq27bna4y8VwO1I10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:E31D3B26D40038B3|rigid:UIkNWXk1N5VvUGB8MZwz4z+187w	false	sufficient binding region:718-935	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q9Z2A0	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649799	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:903297C1A287AAC8|rigid:Xhd/KEjF6Io5sRAC8KhMnrFDREM	false	sufficient binding region:406-611	sufficient binding region:2-101	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DB75	uniprotkb:E9PZQ0	intact:EBI-642482|uniprotkb:Q3UD73|uniprotkb:Q9CYP1|ensembl:ENSMUSP00000004173|ensembl:ENSMUSP00000113889	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:cdip1_mouse(display_long)|uniprotkb:Cdip1(gene name)|psi-mi:Cdip1(display_short)|uniprotkb:LITAF-like protein(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649821	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079946.2|refseq:XP_006522530.1|refseq:XP_006522531.1|refseq:XP_011244298.1|ensembl:ENSMUSG00000004071(gene)|ensembl:ENSMUST00000004173(transcript)|ensembl:ENSMUST00000118703(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0006915"(apoptotic process)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0046872"(metal ion binding)|go:"GO:0098560"(cytoplasmic side of late endosome membrane)|go:"GO:0098574"(cytoplasmic side of lysosomal membrane)|interpro:IPR006629(LPS-induced tumor necrosis factor alpha factor)|interpro:IPR037519	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:26635(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:5/DQvslHpHWSALpBnqr82u87JIg10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:C287340B7CA9D2DC|rigid:8o9oB0qOtFNeJGS2Ea22wg9HIBo	false	sufficient binding region:89-208	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40694	uniprotkb:P35991	intact:EBI-642488	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:smbp2_mouse(display_long)|uniprotkb:ATP-dependent helicase IGHMBP2(gene name synonym)|uniprotkb:Immunoglobulin mu-binding protein 2(gene name synonym)|uniprotkb:Cardiac transcription factor 1(gene name synonym)|uniprotkb:Smbp-2(gene name synonym)|uniprotkb:Ighmbp2(gene name)|psi-mi:Ighmbp2(display_short)|uniprotkb:Smbp2(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649831	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR004483(DNA helicase, putative)|interpro:IPR001374(Single-stranded nucleic acid binding R3H)|interpro:IPR000058(Zinc finger, AN1-type)|interpro:IPR027417|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0021522"(spinal cord motor neuron differentiation)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0032574"(5'-3' RNA helicase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043139"(5'-3' DNA helicase activity)|go:"GO:0043621"(protein self-association)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050905"(neuromuscular process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:1990955"(G-rich single-stranded DNA binding)|go:"GO:0000049"(tRNA binding)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|interpro:IPR034072|interpro:IPR035896|interpro:IPR036867|interpro:IPR041677|interpro:IPR041679	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:23573(secondary-ac)	-	-	caution:The prey construct contains 40 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:VDNTZMrpbjTDVFVqg9CXRItrtKc10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:D533288E4D61EA9B|rigid:+7//Mj53OSSvMA2h4vHmmhuEFV4	false	sufficient binding region:1-153	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61735	uniprotkb:O88643	intact:EBI-494286|uniprotkb:Q921Z2	intact:EBI-457240	psi-mi:cd47_mouse(display_long)|uniprotkb:Integrin-associated protein(gene name synonym)|uniprotkb:Cd47(gene name)|psi-mi:Cd47(display_short)	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649842	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034711.1|interpro:IPR013147(CD47 transmembrane)|interpro:IPR013270(CD47 immunoglobulin-like)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|refseq:XP_006521874.1|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-391160|interpro:IPR006704(CD47 integrin associated protein)|reactome:R-MMU-6798695|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0008228"(opsonization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009986"(cell surface)|go:"GO:0016477"(cell migration)|go:"GO:0022409"(positive regulation of cell-cell adhesion)|go:"GO:0032649"(regulation of interferon-gamma production)|go:"GO:0032653"(regulation of interleukin-10 production)|go:"GO:0032655"(regulation of interleukin-12 production)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0035696"(monocyte extravasation)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0070053"(thrombospondin receptor activity)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070487"(monocyte aggregation)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071349"(cellular response to interleukin-12)|go:"GO:0086080"(protein binding involved in heterotypic cell-cell adhesion)|go:"GO:0098632"(cell-cell adhesion mediator activity)|go:"GO:1904669"(ATP export)|go:"GO:1905450"(negative regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|interpro:IPR037805	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	afcs:16524(primary-reference)|afcs:12488(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AnttsmD0TOll60srfvDk0KAdGLI10090	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	intact-crc:E493C0AAEE4ED12E|rigid:SVk24EPVIr/5v3bk5dZ7EgJraKI	false	sufficient binding region:81-236	sufficient binding region:1-121	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54946	uniprotkb:Q8BWG8	intact:EBI-642500|uniprotkb:Q3TE94|uniprotkb:Q3U6L0|uniprotkb:Q3UNJ5|uniprotkb:Q3UYT7|uniprotkb:Q99LA5|uniprotkb:Q9QYI9|ensembl:ENSMUSP00000008733	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:dnjb6_mouse(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MRJ(gene name synonym)|uniprotkb:mDj4(gene name synonym)|uniprotkb:Dnajb6(gene name)|psi-mi:Dnajb6(display_short)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Mrj(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649852	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033029.1|refseq:NP_001120839.1|refseq:NP_035977.2|ensembl:ENSMUSG00000029131(gene)|ensembl:ENSMUST00000008733(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O54946|reactome:R-MMU-3371453	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:17032(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Snii+B7COng2Zkduai/v24f83bw10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:39D7850F438E2375|rigid:A3HN9iRDPZDR2WHK9VTbgF4GC7w	false	sufficient binding region:19-242	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54946	uniprotkb:Q8BWG8	intact:EBI-642500|uniprotkb:Q3TE94|uniprotkb:Q3U6L0|uniprotkb:Q3UNJ5|uniprotkb:Q3UYT7|uniprotkb:Q99LA5|uniprotkb:Q9QYI9|ensembl:ENSMUSP00000008733	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:dnjb6_mouse(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MRJ(gene name synonym)|uniprotkb:mDj4(gene name synonym)|uniprotkb:Dnajb6(gene name)|psi-mi:Dnajb6(display_short)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Mrj(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649882	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033029.1|refseq:NP_001120839.1|refseq:NP_035977.2|ensembl:ENSMUSG00000029131(gene)|ensembl:ENSMUST00000008733(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O54946|reactome:R-MMU-3371453	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:17032(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Snii+B7COng2Zkduai/v24f83bw10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:751F3BF155C3ECA0|rigid:A3HN9iRDPZDR2WHK9VTbgF4GC7w	false	sufficient binding region:58-232	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54946	uniprotkb:Q8BWG8	intact:EBI-642500|uniprotkb:Q3TE94|uniprotkb:Q3U6L0|uniprotkb:Q3UNJ5|uniprotkb:Q3UYT7|uniprotkb:Q99LA5|uniprotkb:Q9QYI9|ensembl:ENSMUSP00000008733	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:dnjb6_mouse(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MRJ(gene name synonym)|uniprotkb:mDj4(gene name synonym)|uniprotkb:Dnajb6(gene name)|psi-mi:Dnajb6(display_short)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Mrj(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649892	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033029.1|refseq:NP_001120839.1|refseq:NP_035977.2|ensembl:ENSMUSG00000029131(gene)|ensembl:ENSMUST00000008733(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O54946|reactome:R-MMU-3371453	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:17032(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Snii+B7COng2Zkduai/v24f83bw10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:5358D710A9937013|rigid:A3HN9iRDPZDR2WHK9VTbgF4GC7w	false	sufficient binding region:88-242	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61830	uniprotkb:P35991	intact:EBI-642509|uniprotkb:Q8C502|ensembl:ENSMUSP00000028045	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:mrc1_mouse(display_long)|uniprotkb:Mrc1(gene name)|psi-mi:Mrc1(display_short)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649912	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032651.2|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR000772(Ricin B lectin)|interpro:IPR001304(C-type lectin)|interpro:IPR013806(Kringle-like fold)|interpro:IPR016186(C-type lectin-like)|interpro:IPR016187(C-type lectin fold)|interpro:IPR018378|interpro:IPR035992|interpro:IPR036943|mint:Q61830|rcsb pdb:1DQG|rcsb pdb:1DQO|rcsb pdb:1FWU|rcsb pdb:1FWV|reactome:R-MMU-1236978|go:"GO:0071353"(cellular response to interleukin-4)|ensembl:ENSMUSG00000026712(gene)|ensembl:ENSMUST00000028045(transcript)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005537"(mannose binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0009986"(cell surface)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0038024"(cargo receptor activity)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071346"(cellular response to interferon-gamma)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:14838(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AKMn8IHaNDw8UjLk4ZiJ8xDAmaw10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:E25FD614A774D26D|rigid:+zOmv0ezB5U1ikd2B42P5xj1pX0	false	sufficient binding region:677-779	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O09159	uniprotkb:P35991	intact:EBI-642524|uniprotkb:Q3UGH3|uniprotkb:O55037|uniprotkb:Q64443|uniprotkb:Q9DBQ1|ensembl:ENSMUSP00000034121	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:ma2b1_mouse(display_long)|uniprotkb:Lysosomal acid alpha-mannosidase(gene name synonym)|uniprotkb:Mannosidase alpha class 2B member 1(gene name synonym)|uniprotkb:Man2b1(gene name)|psi-mi:Man2b1(display_short)|uniprotkb:Laman(gene name synonym)|uniprotkb:Man2b(gene name synonym)|uniprotkb:Manb(gene name synonym)|uniprotkb:Mannosidase alpha-B(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649922	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034894.2|ensembl:ENSMUSG00000005142(gene)|ensembl:ENSMUST00000034121(transcript)|go:"GO:0004559"(alpha-mannosidase activity)|go:"GO:0005537"(mannose binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005774"(vacuolar membrane)|go:"GO:0006013"(mannose metabolic process)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007611"(learning or memory)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|interpro:IPR000602(Glycoside hydrolase, family 38, core)|interpro:IPR011013(Glycoside hydrolase-type carbohydrate-binding)|interpro:IPR011330(Glycoside hydrolase/deacetylase, beta/alpha-barrel)|interpro:IPR011682(Glycosyl hydrolases 38, C-terminal)|interpro:IPR013780(Glycosyl hydrolase, family 13, all-beta)|interpro:IPR015341(Glycoside hydrolase, family 38, central region)|interpro:IPR027291|interpro:IPR028995|interpro:IPR037094|interpro:IPR041147|mint:O09159|reactome:R-MMU-6798695|reactome:R-MMU-8853383	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:16367(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sPTY5FWcP/BRXNqE4h+dtIhpLNU10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:BEAC08B97CD1F4B5|rigid:dXC1OuW53Ctlp0gXSEf9UetjzqQ	false	sufficient binding region:212-360	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P47802	uniprotkb:E9PZQ0	intact:EBI-642547	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:mtx1_mouse(display_long)|uniprotkb:Mtx1(gene name)|psi-mi:Mtx1(display_short)|uniprotkb:Mtx(gene name synonym)|uniprotkb:Mtxn(gene name synonym)|uniprotkb:Mitochondrial outer membrane import complex protein 1(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649942	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR017410(Metaxin)|interpro:IPR019564|interpro:IPR033468|go:"GO:0001401"(SAM complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0015031"(protein transport)|go:"GO:0016021"(integral component of membrane)|reactome:R-MMU-9013404|interpro:IPR036282|interpro:IPR040079	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:9509(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	caution:The prey construct contains 1 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T5fkFGcA1l5ZZlvuFq6Rd7D8yJQ10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:3A2DE59999739622|rigid:MfDbJctdZlTlj2oDsMQv9NpkgV8	false	sufficient binding region:1-184	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97432	uniprotkb:Q8CIH5	intact:EBI-642554|uniprotkb:Q9JIH9|ensembl:ENSMUSP00000099387|ensembl:ENSMUSP00000099388|ensembl:ENSMUSP00000102836	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:nbr1_mouse(display_long)|uniprotkb:Neighbor of BRCA1 gene 1 protein(gene name synonym)|uniprotkb:Membrane component chromosome 17 surface marker 2 homolog(gene name synonym)|uniprotkb:Nbr1(gene name)|psi-mi:Nbr1(display_short)|uniprotkb:M17s2(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649953	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032702.1|refseq:NP_001239149.1|ensembl:ENSMUSG00000017119(gene)|ensembl:ENSMUST00000103098(transcript)|ensembl:ENSMUST00000103099(transcript)|ensembl:ENSMUST00000107218(transcript)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005829"(cytosol)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016236"(macroautophagy)|go:"GO:0016604"(nuclear body)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0031430"(M band)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043235"(receptor complex)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0051019"(mitogen-activated protein kinase binding)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR009060(UBA-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR032350|interpro:IPR033513|interpro:IPR034852|interpro:IPR043145|mint:P97432|reactome:R-MMU-9664873	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:14879(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:B+P3/9nq+dNGv/Pcy28HI4deZic10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:A3F6C846920B3D1F|rigid:VyAO0FmWjsz2LbkgNt46B5bZY3E	false	sufficient binding region:731-805	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01768	uniprotkb:E9PZQ0	intact:EBI-642573|ensembl:ENSMUSP00000021217|ensembl:ENSMUSP00000103476	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:ndkb_mouse(display_long)|uniprotkb:nm23-M2(gene name synonym)|uniprotkb:P18(gene name synonym)|uniprotkb:Nme2(gene name)|psi-mi:Nme2(display_short)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650003	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070997.1|refseq:NP_032731.1|ensembl:ENSMUSG00000020857(gene)|ensembl:ENSMUST00000021217(transcript)|ensembl:ENSMUST00000072566(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1901363"(heterocyclic compound binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q01768|reactome:R-MMU-499943|reactome:R-MMU-6798695	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:7069(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	caution:The prey construct contains 6 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AJ1Depmyy9zwTEUOZMRO7TKPd1k10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:8BFC7A4E8E895B30|rigid:SVHwEwlqx4g/lRjOcNh6YntED8U	false	sufficient binding region:1-152	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P48453-1	uniprotkb:P35991	intact:EBI-642630|ensembl:ENSMUSP00000125722	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:p48453-1(display_long)|uniprotkb:2B2(isoform synonym)|uniprotkb:Ppp3cb(gene name)|psi-mi:Ppp3cb(display_short)|uniprotkb:Calnb(gene name synonym)|uniprotkb:CAM-PRP catalytic subunit(gene name synonym)|uniprotkb:Calmodulin-dependent calcineurin A subunit beta isoform(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650034	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-642618(p2bb_mouse)|ensembl:ENSMUSG00000021816(gene)|ensembl:ENSMUST00000159027(transcript)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:9398(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YD7q3dcL87htgwHRd5m5ReMlqd010090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:775E1BBD3CD7EC1E|rigid:Tj02/Zw8NtPqW/uVPxD0jA4dE88	false	sufficient binding region:431-525	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QXI7	uniprotkb:Q9Z2A0	intact:EBI-642640	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:q9qxi7_mouse(display_long)|uniprotkb:Pde4b(gene name)|psi-mi:Pde4b(display_short)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650044	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000930"(gamma-tubulin complex)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0004114"(3',5'-cyclic-nucleotide phosphodiesterase activity)|go:"GO:0004115"(3',5'-cyclic-AMP phosphodiesterase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0006198"(cAMP catabolic process)|go:"GO:0007165"(signal transduction)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0009408"(response to heat)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016020"(membrane)|go:"GO:0030552"(cAMP binding)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|interpro:IPR003607(Metal-dependent phosphohydrolase, HD region)|interpro:IPR023088|interpro:IPR002073(3'5'-cyclic nucleotide phosphodiesterase)|interpro:IPR023174|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0035690"|go:"GO:0043197"(dendritic spine)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050900"(leukocyte migration)|go:"GO:0060076"(excitatory synapse)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071944"(cell periphery)|interpro:IPR040844|interpro:IPR036971|interpro:IPR043371	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:18340(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:wb1aa0qdsjoWMDjXfVo2unI/WlU10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:58B77DC9CD217B8F|rigid:FMpi1hT4ATJtCnA20fkW9mS67bo	false	sufficient binding region:309-490	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WVM3	uniprotkb:P42337	intact:EBI-642653|uniprotkb:Q3UBM7|uniprotkb:Q8BSR2|uniprotkb:Q91W13|ensembl:ENSMUSP00000031422|ensembl:ENSMUSP00000113928	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:apc7_mouse(display_long)|uniprotkb:Cyclosome subunit 7(gene name synonym)|uniprotkb:Prediabetic NOD sera-reactive autoantigen(gene name synonym)|uniprotkb:Apc7(gene name synonym)|uniprotkb:Anapc7(gene name)|psi-mi:Anapc7(display_short)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650074	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062779.3|ensembl:ENSMUSG00000029466(gene)|ensembl:ENSMUST00000031422(transcript)|ensembl:ENSMUST00000122010(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-MMU-141430|reactome:R-MMU-174048|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-176407|reactome:R-MMU-176408|reactome:R-MMU-176409|reactome:R-MMU-176412|reactome:R-MMU-179409|reactome:R-MMU-2467813|reactome:R-MMU-2559582|reactome:R-MMU-69017|reactome:R-MMU-983168|go:"GO:0005819"(spindle)	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	afcs:15011(primary-reference)|afcs:18315(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:kGGF+W/eposBQfb3C/PiDJEdC+k10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:010A8DD7090B3268|rigid:ZRrLSNCjAmu2xidXli4Bx9CtUKY	false	sufficient binding region:299-565	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54916	uniprotkb:Q8CIH5	intact:EBI-642662|uniprotkb:Q8C9J9|uniprotkb:Q99LR8|uniprotkb:Q3UAM3|uniprotkb:Q5PPQ9|ensembl:ENSMUSP00000123238	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:reps1_mouse(display_long)|uniprotkb:RalBP1-interacting protein 1(gene name synonym)|uniprotkb:Reps1(gene name)|psi-mi:Reps1(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650084	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104535.1|refseq:NP_033074.2|ensembl:ENSMUSG00000019854(gene)|ensembl:ENSMUST00000126390(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0006897"(endocytosis)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|interpro:IPR000261("EPS15 homology (EH)")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR026814|mint:O54916|rcsb pdb:1FI6|reactome:R-MMU-8856825|reactome:R-MMU-8856828	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:6276(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SUnawYEyzAOseTj6bNkzh2QPfGA10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:575AF35BE5432058|rigid:+VDKoA4iI7bj97p1iJfQaJag6CY	false	sufficient binding region:461-617	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q05144	uniprotkb:O88643	intact:EBI-642680|uniprotkb:Q3TBC4|uniprotkb:Q9D8X9|ensembl:ENSMUSP00000036384	intact:EBI-457240	psi-mi:rac2_mouse(display_long)|uniprotkb:p21-Rac2(gene name synonym)|uniprotkb:Protein EN-7(gene name synonym)|uniprotkb:Rac2(gene name)|psi-mi:Rac2(display_short)	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650094	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033034.1|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006935"(chemotaxis)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010810"(regulation of cell-substrate adhesion)|go:"GO:0016020"(membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042995"(cell projection)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045453"(bone resorption)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060753"(regulation of mast cell chemotaxis)|go:"GO:0071593"(lymphocyte aggregation)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:1902622"(regulation of neutrophil migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:Q05144|reactome:R-MMU-114604|reactome:R-MMU-1222556|reactome:R-MMU-1257604|reactome:R-MMU-4086400|reactome:R-MMU-5668599|reactome:R-MMU-6811558|reactome:R-MMU-9013404|go:"GO:0043304"(regulation of mast cell degranulation)|ensembl:ENSMUSG00000033220(gene)|ensembl:ENSMUST00000043214(transcript)|dip:DIP-41834N	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	afcs:16524(primary-reference)|afcs:15146(secondary-ac)	-	-	caution:The prey construct contains 12 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:e+jv1gu9ydUEvBgplFcRQ6APjw810090	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	intact-crc:089E22D2CC5DAC11|rigid:XwEZpI+9HJahCP7Eg+bTJBl0DfQ	false	sufficient binding region:1-192	sufficient binding region:1-121	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BP92	uniprotkb:E9PZQ0	intact:EBI-642694|uniprotkb:O70341|uniprotkb:A2RT07|ensembl:ENSMUSP00000109915	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:rcn2_mouse(display_long)|uniprotkb:Taipoxin-associated calcium-binding protein 49(gene name synonym)|uniprotkb:Rcn2(gene name)|psi-mi:Rcn2(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650105	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036122.2|ensembl:ENSMUSG00000032320(gene)|ensembl:ENSMUST00000114276(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q8BP92|dip:DIP-46963N	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:23471(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:vsMMmWAPrlDNQDUxzH4wrp1Jub410090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:580752835085CE21|rigid:Zbh3STJ482qFDOoSzMp0b3JsnuM	false	sufficient binding region:1-228	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P47915	uniprotkb:Q9Z2A0	intact:EBI-642703|ensembl:ENSMUSP00000080203|ensembl:ENSMUSP00000096592|ensembl:ENSMUSP00000117834	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:rl29_mouse(display_long)|uniprotkb:Rpl29(gene name)|psi-mi:Rpl29(display_short)|uniprotkb:Rpl43(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650115	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033108.1|refseq:XP_990228.1|refseq:XP_006511723.1|ensembl:ENSMUST00000098994(transcript)|ensembl:ENSMUST00000150576(transcript)|go:"GO:0002181"(cytoplasmic translation)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0006412"(translation)|go:"GO:0008201"(heparin binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042788"(polysomal ribosome)|go:"GO:0045202"(synapse)|interpro:IPR002673(Ribosomal protein L29e)|mint:P47915|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957|ensembl:ENSMUST00000059802(transcript)|ensembl:ENSMUSG00000048758(gene)|refseq:NP_001311462.1|refseq:NP_001311463.1	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:15203(secondary-ac)	-	-	caution:The prey construct contains 9 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Eo9fBkLLj3pU2/Rd3Z/HvzBHxSs10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:866EC127D46D9CFC|rigid:9WsDtAc7PxvYUYVmGBWPcPPXo4I	false	sufficient binding region:?-?	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14148	uniprotkb:P35991	intact:EBI-445010|uniprotkb:Q80UR0|ensembl:ENSMUSP00000071616	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:rl7_mouse(display_long)|uniprotkb:Rpl7(gene name)|psi-mi:Rpl7(display_short)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650125	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035421.2|ensembl:ENSMUSG00000043716(gene)|ensembl:ENSMUST00000058437(transcript)|go:"GO:0000463"("maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0003677"(DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003735"(structural constituent of ribosome)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005844"(polysome)|go:"GO:0006364"(rRNA processing)|go:"GO:0006412"(translation)|go:"GO:0008097"(5S rRNA binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0022625"(cytosolic large ribosomal subunit)|go:"GO:0022626"(cytosolic ribosome)|go:"GO:0031672"(A band)|go:"GO:0042273"(ribosomal large subunit biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0045202"(synapse)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR005998(Ribosomal protein L7, eukaryotic)|interpro:IPR012988(Ribosomal protein L30, N-terminal)|interpro:IPR016082(Ribosomal protein L30, C-terminal)|interpro:IPR018038|interpro:IPR035808|interpro:IPR036919|interpro:IPR039699|mint:P14148|rcsb pdb:6SWA|reactome:R-MMU-156827|reactome:R-MMU-1799339|reactome:R-MMU-6791226|reactome:R-MMU-72689|reactome:R-MMU-72706|reactome:R-MMU-975956|reactome:R-MMU-975957	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:16678(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3mgKWwOhV0qZfTQwfsTkqol4iIY10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:5D87EB60ACDC67B4|rigid:+utC+JQKi60EVGdsU3CVZlGcSJ8	false	sufficient binding region:7-142	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R550	uniprotkb:Q8CIH5	intact:EBI-642709|uniprotkb:Q8CAL8|uniprotkb:Q8CEF6|uniprotkb:Q8R545|uniprotkb:Q8R546|uniprotkb:Q8R547|uniprotkb:Q8R548|uniprotkb:Q8R549|uniprotkb:Q8R551|uniprotkb:Q9CTQ9|uniprotkb:Q9DC14|uniprotkb:Q9JKC3|uniprotkb:B1AZ86|uniprotkb:B1AZ87|ensembl:ENSMUSP00000072840	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:sh3k1_mouse(display_long)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650135	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129199.1|refseq:NP_001129200.1|refseq:NP_067364.2|refseq:XP_006528987.1|ensembl:ENSMUSG00000040990(gene)|ensembl:ENSMUST00000073094(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q8R550|rcsb pdb:1WI7|rcsb pdb:2DA9|rcsb pdb:5XHZ|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866376|reactome:R-MMU-983695|refseq:XP_011246151.1|refseq:XP_011246153.1|refseq:NP_001277590.1|refseq:NP_001277593.1	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:23893(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Fd7WikE+fZIgob7Ax2vr9J291N010090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:B359006DAE4E026B|rigid:KBRMmNdKkzTlstKDr/njkM2ehsQ	false	sufficient binding region:450-709	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R550	uniprotkb:Q8CIH5	intact:EBI-642709|uniprotkb:Q8CAL8|uniprotkb:Q8CEF6|uniprotkb:Q8R545|uniprotkb:Q8R546|uniprotkb:Q8R547|uniprotkb:Q8R548|uniprotkb:Q8R549|uniprotkb:Q8R551|uniprotkb:Q9CTQ9|uniprotkb:Q9DC14|uniprotkb:Q9JKC3|uniprotkb:B1AZ86|uniprotkb:B1AZ87|ensembl:ENSMUSP00000072840	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:sh3k1_mouse(display_long)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129199.1|refseq:NP_001129200.1|refseq:NP_067364.2|refseq:XP_006528987.1|ensembl:ENSMUSG00000040990(gene)|ensembl:ENSMUST00000073094(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q8R550|rcsb pdb:1WI7|rcsb pdb:2DA9|rcsb pdb:5XHZ|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866376|reactome:R-MMU-983695|refseq:XP_011246151.1|refseq:XP_011246153.1|refseq:NP_001277590.1|refseq:NP_001277593.1	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:23893(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Fd7WikE+fZIgob7Ax2vr9J291N010090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:F1F0779ABACB5506|rigid:KBRMmNdKkzTlstKDr/njkM2ehsQ	false	sufficient binding region:653-709	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35149	uniprotkb:E9PZQ0	intact:EBI-642780|uniprotkb:Q3UYZ9|uniprotkb:O35154|ensembl:ENSMUSP00000005952	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:znt4_mouse(display_long)|uniprotkb:Solute carrier family 30 member 4(gene name synonym)|uniprotkb:Lethal milk protein(gene name synonym)|uniprotkb:Slc30a4(gene name)|psi-mi:Slc30a4(display_short)|uniprotkb:Lm(gene name synonym)|uniprotkb:Znt4(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035904.2|ensembl:ENSMUSG00000005802(gene)|ensembl:ENSMUST00000005952(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005770"(late endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0009636"(response to toxic substance)|go:"GO:0010043"(response to zinc ion)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031902"(late endosome membrane)|go:"GO:0055069"(zinc ion homeostasis)|go:"GO:0061088"(regulation of sequestering of zinc ion)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR002524(Cation efflux protein)|interpro:IPR027469|refseq:NP_001277922.1	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:16972(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RzyO1JZ1i4RzClMDZb6BeSXrppU10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:C1EAB42AED23CED1|rigid:NH6g9WmMFi8XXvk+kbP7WcpQBmI	false	sufficient binding region:15-131	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ES52	uniprotkb:Q8CIH5	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650175	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:6877(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:1F878548B8916177|rigid:VEAL1n28WvxPyvOB1/P6rKu4+v0	false	sufficient binding region:99-340	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ES52	uniprotkb:Q8CIH5	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650185	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:6877(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:817ABCCE32B8FEC1|rigid:VEAL1n28WvxPyvOB1/P6rKu4+v0	false	sufficient binding region:116-197	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ES52	uniprotkb:Q8CIH5	intact:EBI-300210|ensembl:ENSMUSP00000127941|uniprotkb:Q3UPF9|uniprotkb:Q4U212|uniprotkb:Q61034|uniprotkb:Q61173|uniprotkb:Q61181|uniprotkb:Q9JKR7|uniprotkb:Q9JLF9|uniprotkb:Q9JLG0|uniprotkb:Q9QVN8|uniprotkb:Q9WUC2	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:ship1_mouse(display_long)|uniprotkb:Inpp5d(gene name)|psi-mi:Inpp5d(display_short)|uniprotkb:Ship(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase of 145 kDa(gene name synonym)|uniprotkb:p150Ship(gene name synonym)|uniprotkb:7a33(gene name synonym)|uniprotkb:Ship1(gene name synonym)|uniprotkb:SH2 domain-containing inositol 5'-phosphatase 1(gene name synonym)|uniprotkb:Inositol polyphosphate-5-phosphatase D(gene name synonym)|uniprotkb:Phosphatidylinositol-4,5-bisphosphate 5-phosphatase(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650195	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026288(gene)|ensembl:ENSMUST00000169754(transcript)|go:"GO:0004439"(phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0004445"(inositol-polyphosphate 5-phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0008340"(determination of adult lifespan)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030487"(inositol-4,5-bisphosphate 5-phosphatase activity)|go:"GO:0030853"(negative regulation of granulocyte differentiation)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0034485"(phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045656"(negative regulation of monocyte differentiation)|go:"GO:0045659"(negative regulation of neutrophil differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045779"(negative regulation of bone resorption)|go:"GO:0046856"(phosphatidylinositol dephosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:0052658"(inositol-1,4,5-trisphosphate 5-phosphatase activity)|go:"GO:0052659"(inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity)|interpro:IPR000300(Inositol polyphosphate related phosphatase)|interpro:IPR000980(SH2 motif)|interpro:IPR005135(Endonuclease/exonuclease/phosphatase)|interpro:IPR036691|interpro:IPR036860|go:"GO:0050777"(negative regulation of immune response)|rcsb pdb:6DLG|reactome:R-MMU-1660499|reactome:R-MMU-1855204|reactome:R-MMU-202424|reactome:R-MMU-210990|reactome:R-MMU-912526|refseq:NP_001103662.1|refseq:NP_001103663.1|refseq:NP_034696.2	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:6877(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ipXHzUIAHLTMnjElS7ngcCqFuak10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:B374ADC4D4A384B4|rigid:VEAL1n28WvxPyvOB1/P6rKu4+v0	false	sufficient binding region:116-438	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54941	uniprotkb:P35991	intact:EBI-642789|uniprotkb:Q8BPD9|ensembl:ENSMUSP00000099422	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:smce1_mouse(display_long)|uniprotkb:BRG1-associated factor 57(gene name synonym)|uniprotkb:Smarce1(gene name)|psi-mi:Smarce1(display_short)|uniprotkb:Baf57(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650205	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065643.1|ensembl:ENSMUSG00000037935(gene)|ensembl:ENSMUST00000103133(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006337"(nucleosome disassembly)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0008080"(N-acetyltransferase activity)|go:"GO:0016514"(SWI/SNF complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0022008"(neurogenesis)|go:"GO:0043044"|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0071564"(npBAF complex)|go:"GO:0071565"(nBAF complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR030089|interpro:IPR036910|mint:O54941|reactome:R-MMU-3214858|reactome:R-MMU-8939243|go:"GO:0003677"(DNA binding)|dip:DIP-39985N	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:23797(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:W5MLVNJ0Jj6hoGwVy2E2HzKx/fY10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:36739C750DB59FAD|rigid:wCyVUpXrKUnmgiqdJv1RrfItSzs	false	sufficient binding region:204-373	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51807	uniprotkb:Q8CIH5	intact:EBI-642797|uniprotkb:Q5M8S6|ensembl:ENSMUSP00000137171|ensembl:ENSMUSP00000135978|ensembl:ENSMUSP00000090644|ensembl:ENSMUSP00000127990	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:dylt1_mouse(display_long)|uniprotkb:T-complex testis-specific protein 1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym)|uniprotkb:Tctex1(gene name synonym)|uniprotkb:Tctex-1(gene name synonym)|uniprotkb:Dynlt1(gene name)|psi-mi:Dynlt1(display_short)|uniprotkb:Activator of G-protein signaling 2(gene name synonym)|uniprotkb:Tctel1(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650215	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001160099.1|refseq:NP_001160101.1|refseq:NP_001160102.1|refseq:NP_033368.1|ensembl:ENSMUST00000092966(transcript)|ensembl:ENSMUST00000169415(transcript)|ensembl:ENSMUST00000179554(transcript)|ensembl:ENSMUST00000179569(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0099503"(secretory vesicle)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|mint:P51807|rcsb pdb:5WI4|reactome:R-MMU-6798695|go:"GO:0030742"(GTP-dependent protein binding)|ensembl:ENSMUSG00000000579(gene)|ensembl:ENSMUSG00000092074(gene)|ensembl:ENSMUSG00000095677(gene)|ensembl:ENSMUSG00000096255(gene)|refseq:XP_017172676.1	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:9401(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fn6QN4J3aA++93iJwG3rFDjPBvM10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:C555F5F678176110|rigid:OshBl2TzHUtQcLcxZ9RcBtNS2Rw	false	sufficient binding region:1-113	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01320	uniprotkb:Q9Z2A0	intact:EBI-642809|uniprotkb:E9PX08|ensembl:ENSMUSP00000068896	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:top2a_mouse(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:Top2a(gene name)|psi-mi:Top2a(display_short)|uniprotkb:Top2(gene name synonym)|uniprotkb:Top-2(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650225	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006533216.1|refseq:NP_035753.2|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:Q01320|reactome:R-MMU-4615885|interpro:IPR020568|ensembl:ENSMUSG00000020914(gene)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030261"(chromosome condensation)|ensembl:ENSMUST00000068031(transcript)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:0051309"(female meiosis chromosome separation)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|go:"GO:0030263"(apoptotic chromosome condensation)|dip:DIP-40621N	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:16882(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4bT7YxXbxkbqULDvXoFRreoX9Gs10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:BCE2C118B876A1B9|rigid:JbfmdXaDXg50RG5q9JsUedrvkhw	false	sufficient binding region:1504-1528	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64321	uniprotkb:Q8CIH5	intact:EBI-642868|uniprotkb:Q80VV5|ensembl:ENSMUSP00000103055|ensembl:ENSMUSP00000103056|ensembl:ENSMUSP00000103058|ensembl:ENSMUSP00000029677	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:zbt7b_mouse(display_long)|uniprotkb:Zinc finger protein 67(gene name synonym)|uniprotkb:Zinc finger protein Th-POK(gene name synonym)|uniprotkb:T-helper-inducing POZ/Krueppel-like factor(gene name synonym)|uniprotkb:Krueppel-related zinc finger protein cKrox(gene name synonym)|uniprotkb:Zbtb7b(gene name)|psi-mi:Zbtb7b(display_short)|uniprotkb:Thpok(gene name synonym)|uniprotkb:Zfp67(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650348	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033591.2|refseq:XP_006501376.1|refseq:XP_006501377.1|refseq:XP_006501379.1|refseq:XP_006501380.1|refseq:XP_006501381.1|refseq:XP_006501382.1|ensembl:ENSMUSG00000028042(gene)|ensembl:ENSMUST00000029677(transcript)|ensembl:ENSMUST00000107432(transcript)|ensembl:ENSMUST00000107433(transcript)|ensembl:ENSMUST00000107435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007595"(lactation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043376"(regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000640"(positive regulation of SREBP signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000210(BTB/POZ-like)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0051141"(negative regulation of NK T cell proliferation)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q64321	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:15602(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sU1MIrKZnvkMEoOdVf75ZNnmwoQ10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:74FC9D08FBBC262E|rigid:svyT5b5daLWsswdwGZAt5dzpLu4	false	sufficient binding region:133-317	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64321	uniprotkb:Q8CIH5	intact:EBI-642868|uniprotkb:Q80VV5|ensembl:ENSMUSP00000103055|ensembl:ENSMUSP00000103056|ensembl:ENSMUSP00000103058|ensembl:ENSMUSP00000029677	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:zbt7b_mouse(display_long)|uniprotkb:Zinc finger protein 67(gene name synonym)|uniprotkb:Zinc finger protein Th-POK(gene name synonym)|uniprotkb:T-helper-inducing POZ/Krueppel-like factor(gene name synonym)|uniprotkb:Krueppel-related zinc finger protein cKrox(gene name synonym)|uniprotkb:Zbtb7b(gene name)|psi-mi:Zbtb7b(display_short)|uniprotkb:Thpok(gene name synonym)|uniprotkb:Zfp67(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650358	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033591.2|refseq:XP_006501376.1|refseq:XP_006501377.1|refseq:XP_006501379.1|refseq:XP_006501380.1|refseq:XP_006501381.1|refseq:XP_006501382.1|ensembl:ENSMUSG00000028042(gene)|ensembl:ENSMUST00000029677(transcript)|ensembl:ENSMUST00000107432(transcript)|ensembl:ENSMUST00000107433(transcript)|ensembl:ENSMUST00000107435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007595"(lactation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043376"(regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000640"(positive regulation of SREBP signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000210(BTB/POZ-like)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0051141"(negative regulation of NK T cell proliferation)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q64321	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:15602(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sU1MIrKZnvkMEoOdVf75ZNnmwoQ10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:76120DB7CCD4B06B|rigid:svyT5b5daLWsswdwGZAt5dzpLu4	false	sufficient binding region:145-343	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64321	uniprotkb:Q8CIH5	intact:EBI-642868|uniprotkb:Q80VV5|ensembl:ENSMUSP00000103055|ensembl:ENSMUSP00000103056|ensembl:ENSMUSP00000103058|ensembl:ENSMUSP00000029677	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:zbt7b_mouse(display_long)|uniprotkb:Zinc finger protein 67(gene name synonym)|uniprotkb:Zinc finger protein Th-POK(gene name synonym)|uniprotkb:T-helper-inducing POZ/Krueppel-like factor(gene name synonym)|uniprotkb:Krueppel-related zinc finger protein cKrox(gene name synonym)|uniprotkb:Zbtb7b(gene name)|psi-mi:Zbtb7b(display_short)|uniprotkb:Thpok(gene name synonym)|uniprotkb:Zfp67(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650368	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033591.2|refseq:XP_006501376.1|refseq:XP_006501377.1|refseq:XP_006501379.1|refseq:XP_006501380.1|refseq:XP_006501381.1|refseq:XP_006501382.1|ensembl:ENSMUSG00000028042(gene)|ensembl:ENSMUST00000029677(transcript)|ensembl:ENSMUST00000107432(transcript)|ensembl:ENSMUST00000107433(transcript)|ensembl:ENSMUST00000107435(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007595"(lactation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0031065"(positive regulation of histone deacetylation)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032868"(response to insulin)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:1990845"(adaptive thermogenesis)|go:"GO:0043370"(regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043372"(positive regulation of CD4-positive, alpha-beta T cell differentiation)|go:"GO:0043376"(regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:0043377"(negative regulation of CD8-positive, alpha-beta T cell differentiation)|go:"GO:2000320"(negative regulation of T-helper 17 cell differentiation)|go:"GO:2000640"(positive regulation of SREBP signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000210(BTB/POZ-like)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046872"(metal ion binding)|go:"GO:0051141"(negative regulation of NK T cell proliferation)|interpro:IPR011333(BTB/POZ fold)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q64321	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:15602(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sU1MIrKZnvkMEoOdVf75ZNnmwoQ10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:1E1092A0227E6222|rigid:svyT5b5daLWsswdwGZAt5dzpLu4	false	sufficient binding region:172-409	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z2R9	uniprotkb:P42337	intact:EBI-642878|uniprotkb:Q8C024|uniprotkb:Q8K123|uniprotkb:Q9CTP5|uniprotkb:Q9D601|uniprotkb:Q2TA96|uniprotkb:Q69ZK8|ensembl:ENSMUSP00000098056	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:e2ak1_mouse(display_long)|uniprotkb:Heme-regulated eukaryotic initiation factor eIF-2-alpha kinase(gene name synonym)|uniprotkb:Hemin-sensitive initiation factor 2-alpha kinase(gene name synonym)|uniprotkb:Heme-regulated inhibitor(gene name synonym)|uniprotkb:Heme-controlled repressor(gene name synonym)|uniprotkb:Eif2ak1(gene name)|psi-mi:Eif2ak1(display_short)|uniprotkb:Hri(gene name synonym)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650399	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038585.2|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0140467"(integrated stress response signaling)|go:"GO:0140468"(HRI-mediated signaling)|go:"GO:1990641"(response to iron ion starvation)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|ensembl:ENSMUSG00000029613(gene)|ensembl:ENSMUST00000100487(transcript)|go:"GO:0002526"(acute inflammatory response)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004694"(eukaryotic translation initiation factor 2alpha kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006417"(regulation of translation)|go:"GO:0006909"(phagocytosis)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010999"(regulation of eIF2 alpha phosphorylation by heme)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0020037"(heme binding)|go:"GO:0030225"(macrophage differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046501"(protoporphyrinogen IX metabolic process)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046984"(regulation of hemoglobin biosynthetic process)|go:"GO:0046986"(negative regulation of hemoglobin biosynthetic process)|go:"GO:0055072"(iron ion homeostasis)	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	afcs:15011(primary-reference)|afcs:17271(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mjrG+odMSzkH6Nu2Pen8tZru3GY10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:C98CAB308179EB8E|rigid:fxLTwc5IXphFijNi0098d0xwzIg	false	sufficient binding region:551-619	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64143	uniprotkb:P42337	intact:EBI-642901|ensembl:ENSMUSP00000030464	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:p55g_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:p55PIK(gene name synonym)|uniprotkb:Pik3r3(gene name)|psi-mi:Pik3r3(display_short)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650409	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_853616.1|interpro:IPR035022|interpro:IPR036860|reactome:R-MMU-114604|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-912526|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-912631|interpro:IPR032498|interpro:IPR035020|ensembl:ENSMUSG00000028698(gene)|ensembl:ENSMUST00000030464(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0043491"(protein kinase B signaling)|refseq:XP_017175528.1|refseq:XP_017175529.1	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	afcs:15011(primary-reference)|afcs:52685(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1xjaa7ceA151Mo51DvSlCFeTTFY10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:6C01F82FFFD34B7C|rigid:Nvl2XZNRbmO67SEvB9xrisnYXic	false	sufficient binding region:137-347	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61074	uniprotkb:P35991	intact:EBI-642919|ensembl:ENSMUSP00000031032	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:ppm1g_mouse(display_long)|uniprotkb:Protein phosphatase 2C isoform gamma(gene name synonym)|uniprotkb:Protein phosphatase magnesium-dependent 1 gamma(gene name synonym)|uniprotkb:Protein phosphatase 1C(gene name synonym)|uniprotkb:Fibroblast growth factor-inducible protein 13(gene name synonym)|uniprotkb:Ppm1g(gene name)|psi-mi:Ppm1g(display_short)|uniprotkb:Fin13(gene name synonym)|uniprotkb:Ppm1c(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650429	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032040.1|ensembl:ENSMUSG00000029147(gene)|ensembl:ENSMUST00000031032(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004722"(protein serine/threonine phosphatase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0016020"(membrane)|go:"GO:0035970"(peptidyl-threonine dephosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0106306"|go:"GO:0106307"|interpro:IPR000222(Protein phosphatase 2C,  manganese/magnesium aspartate binding site)|interpro:IPR001932(Protein phosphatase 2C-related)|interpro:IPR015655(Protein phosphatase 2C)|interpro:IPR036457|mint:Q61074	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:14327(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:OazpV/JqeZD+TpovURxYWY9t6VI10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:7016AE0E71461D72|rigid:BnQAofpE/wlYcMELibdQjYllSPY	false	sufficient binding region:461-542	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R0L9	uniprotkb:Q8BWG8	intact:EBI-642927|uniprotkb:Q3UM47|uniprotkb:Q9Z317|ensembl:ENSMUSP00000019962	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:muc24_mouse(display_long)|uniprotkb:Endolyn(gene name synonym)|uniprotkb:Cd164(gene name)|psi-mi:Cd164(display_short)|uniprotkb:Multi-glycosylated core protein 24(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650439	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058594.1|ensembl:ENSMUSG00000019818(gene)|ensembl:ENSMUST00000019962(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007157"(heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules)|go:"GO:0007517"(muscle organ development)|go:"GO:0010008"(endosome membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031410"(cytoplasmic vesicle)|interpro:IPR007947(CD164 related protein)	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:17812(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:teA9ATISpR8GsFkqc1w2DPIZSUk10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:D65FEDE657E5043F|rigid:hDUh3KlFkhOQlJswY1KtKfEum/8	false	sufficient binding region:119-197	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61491	uniprotkb:E9PZQ0	intact:EBI-642944	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:q61491_mouse(display_long)|uniprotkb:Zfp97(gene name)|psi-mi:Zfp97(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650470	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR036051|interpro:IPR036236	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:16966(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:9aawDNJKpT/07zRBL7d0EaY5T9k10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:406FF9EC0203FC9D|rigid:mFso4eepxkg1l84hMtSHpkbyisE	false	sufficient binding region:117-546	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CQE0	uniprotkb:E9PZQ0	intact:EBI-642952|uniprotkb:Q9WTR9|uniprotkb:Q9WTS0|ensembl:ENSMUSP00000157047|ensembl:ENSMUSP00000157102	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:rn138_mouse(display_long)|uniprotkb:RING finger protein 138(gene name synonym)|uniprotkb:Rnf138(gene name)|psi-mi:Rnf138(display_short)|uniprotkb:Trif(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF138(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650480	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062680.2|refseq:NP_997506.1|refseq:NP_001289934.1|refseq:NP_001289940.1|refseq:XP_011245277.1|ensembl:ENSMUSG00000024317(gene)|ensembl:ENSMUST00000234107(transcript)|ensembl:ENSMUST00000234536(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008598(Drought induced 19)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034734|reactome:R-MMU-983168	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:18226(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:F2gugCKceH3ZCNNBlxOpt2dFYgA10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:F2F20259D664324C|rigid:EoKcKKXYzZiLhyQ9God25e154A4	false	sufficient binding region:1-95	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CQE0	uniprotkb:E9PZQ0	intact:EBI-642952|uniprotkb:Q9WTR9|uniprotkb:Q9WTS0|ensembl:ENSMUSP00000157047|ensembl:ENSMUSP00000157102	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:rn138_mouse(display_long)|uniprotkb:RING finger protein 138(gene name synonym)|uniprotkb:Rnf138(gene name)|psi-mi:Rnf138(display_short)|uniprotkb:Trif(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF138(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650490	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062680.2|refseq:NP_997506.1|refseq:NP_001289934.1|refseq:NP_001289940.1|refseq:XP_011245277.1|ensembl:ENSMUSG00000024317(gene)|ensembl:ENSMUST00000234107(transcript)|ensembl:ENSMUST00000234536(transcript)|go:"GO:0000724"(double-strand break repair via homologous recombination)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0010792"(DNA double-strand break processing involved in repair via single-strand annealing)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035861"(site of double-strand break)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR008598(Drought induced 19)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR034734|reactome:R-MMU-983168	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:18226(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:F2gugCKceH3ZCNNBlxOpt2dFYgA10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:CFE0D42ECB0283B2|rigid:EoKcKKXYzZiLhyQ9God25e154A4	false	sufficient binding region:10-95	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70333	uniprotkb:E9PZQ0	intact:EBI-642963|uniprotkb:Q99LR6|uniprotkb:Q9DBP4|ensembl:ENSMUSP00000024959	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:cript_mouse(display_long)|uniprotkb:Cysteine-rich interactor of PDZ three(gene name synonym)|uniprotkb:Cript(gene name)|psi-mi:Cript(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650500	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064320.1|go:"GO:0045184"(establishment of protein localization)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1902897"(regulation of postsynaptic density protein 95 clustering)|interpro:IPR019367|go:"GO:0044877"(protein-containing complex binding)|ensembl:ENSMUSG00000024146(gene)|ensembl:ENSMUST00000024959(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0008017"(microtubule binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030425"(dendrite)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0043198"(dendritic shaft)	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:18376(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	caution:The prey construct contains 21 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sTux4qUHvJ50QfmF+Mf13lWoq8010090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:4FB919FD685BE044|rigid:lX/U82baSn3mHQxBmW9yIpmwDW8	false	sufficient binding region:1-101	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:A3KGF7	uniprotkb:P33609	intact:EBI-681172|uniprotkb:Q2M4J1|uniprotkb:Q3TER8|uniprotkb:Q8BI81|ensembl:ENSMUSP00000099583	intact:EBI-688051|ensembl:ENSMUSP00000006856	psi-mi:plcb2_mouse(display_long)|uniprotkb:Phospholipase C-beta-2(gene name synonym)|uniprotkb:Plcb2(gene name)|psi-mi:Plcb2(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-2(gene name synonym)	psi-mi:dpola_mouse(display_long)|uniprotkb:Pola1(gene name)|psi-mi:Pola1(display_short)|uniprotkb:Pola(gene name synonym)|uniprotkb:DNA polymerase alpha catalytic subunit p180(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688062	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277719.1|refseq:NP_808236.2|ensembl:ENSMUSG00000040061(gene)|ensembl:ENSMUST00000102524(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050913"(sensory perception of bitter taste)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR011992(EF-Hand type)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028403|interpro:IPR035892|interpro:IPR037862|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657	refseq:NP_032918.1|ensembl:ENSMUSG00000006678(gene)|ensembl:ENSMUST00000006856(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0000731"(DNA synthesis involved in DNA repair)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003688"(DNA replication origin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003887"(DNA-directed DNA polymerase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005658"("alpha DNA polymerase:primase complex")|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0006260"(DNA replication)|go:"GO:0006269"(DNA replication, synthesis of RNA primer)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006272"(leading strand elongation)|go:"GO:0006273"(lagging strand elongation)|go:"GO:0006303"(double-strand break repair via nonhomologous end joining)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0017076"(purine nucleotide binding)|go:"GO:0019103"(pyrimidine nucleotide binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032479"(regulation of type I interferon production)|go:"GO:0051539"(4 iron, 4 sulfur cluster binding)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1902975"(mitotic DNA replication initiation)|interpro:IPR006133(DNA-directed DNA polymerase, family B, exonuclease)|interpro:IPR006134(DNA-directed DNA polymerase, family B, conserved region)|interpro:IPR006172(DNA-directed DNA polymerase, family B)|interpro:IPR012337(Polynucleotidyl transferase, Ribonuclease H fold)|interpro:IPR015088(Zinc finger, DNA-directed DNA polymerase, family B, alpha)|interpro:IPR017964|interpro:IPR024647|interpro:IPR036397|interpro:IPR038256|interpro:IPR042087|interpro:IPR043502|reactome:R-MMU-113501|reactome:R-MMU-174411|reactome:R-MMU-174430|reactome:R-MMU-68952|reactome:R-MMU-68962|reactome:R-MMU-69091|reactome:R-MMU-69166|reactome:R-MMU-69183	afcs:15056(secondary-ac)|afcs:21846(primary-reference)|afcs:15056(primary-reference)	comment:afcs Y2H protein 21846. Translated from nucleotide sequence.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MH225dCuWXd8Xw3H1Kv/8ITyluQ10090	rogid:6ZxRfRf1dB53T+WKCsAZNXQTTdE10090	intact-crc:82DFBA19AC559362|rigid:drD4zidy8Pr7ropCChVwqB3zGqc	false	sufficient binding region:660-800	sufficient binding region:245-496	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:A3KGF7	uniprotkb:Q9CXF4	intact:EBI-681172|uniprotkb:Q2M4J1|uniprotkb:Q3TER8|uniprotkb:Q8BI81|ensembl:ENSMUSP00000099583	intact:EBI-688073|uniprotkb:Q3UI41|ensembl:ENSMUSP00000020339	psi-mi:plcb2_mouse(display_long)|uniprotkb:Phospholipase C-beta-2(gene name synonym)|uniprotkb:Plcb2(gene name)|psi-mi:Plcb2(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-2(gene name synonym)	psi-mi:tbc15_mouse(display_long)|uniprotkb:Tbc1d15(gene name)|psi-mi:Tbc1d15(display_short)|uniprotkb:GTPase-activating protein RAB7(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688081	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277719.1|refseq:NP_808236.2|ensembl:ENSMUSG00000040061(gene)|ensembl:ENSMUST00000102524(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050913"(sensory perception of bitter taste)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR011992(EF-Hand type)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028403|interpro:IPR035892|interpro:IPR037862|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657	refseq:NP_079982.3|ensembl:ENSMUSG00000020130(gene)|ensembl:ENSMUST00000020339(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR000195(RabGAP/TBC)|interpro:IPR021935|interpro:IPR035969|reactome:R-MMU-8854214	afcs:21846(primary-reference)|afcs:26655(primary-reference)|afcs:26655(secondary-ac)	comment:afcs Y2H protein 21846. Translated from nucleotide sequence.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MH225dCuWXd8Xw3H1Kv/8ITyluQ10090	rogid:L0/dKYoB1DP62jpikABtqE/e5hM10090	intact-crc:948F737DE5358A8B|rigid:xgmtXHmBDDjY4PZxzlkc3YddeWI	false	sufficient binding region:660-800	sufficient binding region:243-465	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70168	uniprotkb:A3KGF7	intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479	intact:EBI-681172|uniprotkb:Q2M4J1|uniprotkb:Q3TER8|uniprotkb:Q8BI81|ensembl:ENSMUSP00000099583	psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym)	psi-mi:plcb2_mouse(display_long)|uniprotkb:Phospholipase C-beta-2(gene name synonym)|uniprotkb:Plcb2(gene name)|psi-mi:Plcb2(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688094	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N	refseq:NP_001277719.1|refseq:NP_808236.2|ensembl:ENSMUSG00000040061(gene)|ensembl:ENSMUST00000102524(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050913"(sensory perception of bitter taste)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR011992(EF-Hand type)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028403|interpro:IPR035892|interpro:IPR037862|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657	afcs:21846(primary-reference)|afcs:14635(primary-reference)|afcs:14635(secondary-ac)	-	comment:afcs Y2H protein 21846. Translated from nucleotide sequence.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090	rogid:MH225dCuWXd8Xw3H1Kv/8ITyluQ10090	intact-crc:A5BDD8EECAFBE67F|rigid:b7TIpjzHxp3Ic3szoi4tP1wwQDE	false	sufficient binding region:125-544	sufficient binding region:660-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:A3KGF7	uniprotkb:P14733	intact:EBI-681172|uniprotkb:Q2M4J1|uniprotkb:Q3TER8|uniprotkb:Q8BI81|ensembl:ENSMUSP00000099583	intact:EBI-445247|uniprotkb:Q61791|ensembl:ENSMUSP00000025486	psi-mi:plcb2_mouse(display_long)|uniprotkb:Phospholipase C-beta-2(gene name synonym)|uniprotkb:Plcb2(gene name)|psi-mi:Plcb2(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-2(gene name synonym)	psi-mi:lmnb1_mouse(display_long)|uniprotkb:Lmnb1(gene name)|psi-mi:Lmnb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277719.1|refseq:NP_808236.2|ensembl:ENSMUSG00000040061(gene)|ensembl:ENSMUST00000102524(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050913"(sensory perception of bitter taste)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR011992(EF-Hand type)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028403|interpro:IPR035892|interpro:IPR037862|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657	refseq:NP_034851.2|mint:P14733|reactome:R-MMU-9035034|reactome:R-MMU-2559584|reactome:R-MMU-352238|reactome:R-MMU-4419969|reactome:R-MMU-9013405|ensembl:ENSMUSG00000024590(gene)|ensembl:ENSMUST00000025486(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005638"(lamin filament)|go:"GO:0005652"(nuclear lamina)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010971"(positive regulation of G2/M transition of mitotic cell cycle)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:1904609"(cellular response to monosodium L-glutamate)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001322(Intermediate filament, C-terminal)|interpro:IPR018039|interpro:IPR036415|interpro:IPR039008|go:"GO:0003690"(double-stranded DNA binding)	afcs:21846(primary-reference)|afcs:6288(primary-reference)|afcs:6288(secondary-ac)	comment:afcs Y2H protein 21846. Translated from nucleotide sequence.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MH225dCuWXd8Xw3H1Kv/8ITyluQ10090	rogid:/Mo4KS6v6KhDRlYgD5CVVVtWVD810090	intact-crc:009708B10F835283|rigid:BdfSPkzOeLcMcYk/lYdwYXQhE2A	false	sufficient binding region:660-800	sufficient binding region:303-538	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60664	uniprotkb:A3KGF7	intact:EBI-688116|uniprotkb:Q7TMU8	intact:EBI-681172|uniprotkb:Q2M4J1|uniprotkb:Q3TER8|uniprotkb:Q8BI81|ensembl:ENSMUSP00000099583	psi-mi:irag2_mouse(display_long)|uniprotkb:Irag2(gene name)|psi-mi:Irag2(display_short)|uniprotkb:Jaw1(gene name synonym)|uniprotkb:Lrmp(gene name synonym)|uniprotkb:Lymphoid-restricted membrane protein(gene name synonym)|uniprotkb:Protein Jaw1(gene name synonym)	psi-mi:plcb2_mouse(display_long)|uniprotkb:Phospholipase C-beta-2(gene name synonym)|uniprotkb:Plcb2(gene name)|psi-mi:Plcb2(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688126	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008677(MRVI1)|refseq:NP_001268909.1|go:"GO:0000922"(spindle pole)|go:"GO:0002376"(immune system process)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005694"(chromosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006997"(nucleus organization)|go:"GO:0007338"(single fertilization)|go:"GO:0008017"(microtubule binding)|go:"GO:0030176"(integral component of endoplasmic reticulum membrane)	refseq:NP_001277719.1|refseq:NP_808236.2|ensembl:ENSMUSG00000040061(gene)|ensembl:ENSMUST00000102524(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050913"(sensory perception of bitter taste)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR011992(EF-Hand type)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028403|interpro:IPR035892|interpro:IPR037862|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657	afcs:21846(primary-reference)|afcs:14741(primary-reference)|afcs:14741(secondary-ac)	-	comment:afcs Y2H protein 21846. Translated from nucleotide sequence.	caution:The prey construct contains 26 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:DyUxo5y3yVY7O83jUohbdC42XsA10090	rogid:MH225dCuWXd8Xw3H1Kv/8ITyluQ10090	intact-crc:439B061DBBA53CA7|rigid:yLQgDkV4NwRPyVQjsyY6BBVQcY0	false	sufficient binding region:1-235	sufficient binding region:660-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-686955	uniprotkb:Q8CIH5	afcs:30629	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:waspbp_mouse_protein(display_short)|psi-mi:EBI-686955(display_long)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:30629(primary-reference)|afcs:30629(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"AfCS Y2H protein 30629. Sequence retrieved from cross-reference: protein GI:13507686."|comment:"Similar to Wiskott-Aldrich syndrome binding protein SPN90_MOUSE (87%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:h3JTmggOZ0LfFzirWIhg+lBu40M10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:8A33982AF344633E|rigid:OK57bMdwD+dgB201IIC0TuZ7kw8	false	sufficient binding region:150-510	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-686955	uniprotkb:Q8CIH5	afcs:30629	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:waspbp_mouse_protein(display_short)|psi-mi:EBI-686955(display_long)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688150	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:30629(primary-reference)|afcs:30629(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"AfCS Y2H protein 30629. Sequence retrieved from cross-reference: protein GI:13507686."|comment:"Similar to Wiskott-Aldrich syndrome binding protein SPN90_MOUSE (87%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:h3JTmggOZ0LfFzirWIhg+lBu40M10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:CEEC739423F48CDF|rigid:OK57bMdwD+dgB201IIC0TuZ7kw8	false	sufficient binding region:164-510	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35887	uniprotkb:A3KGF7	intact:EBI-688160|ensembl:ENSMUSP00000031779	intact:EBI-681172|uniprotkb:Q2M4J1|uniprotkb:Q3TER8|uniprotkb:Q8BI81|ensembl:ENSMUSP00000099583	psi-mi:calu_mouse(display_long)|uniprotkb:Crocalbin(gene name synonym)|uniprotkb:Calu(gene name)|psi-mi:Calu(display_short)	psi-mi:plcb2_mouse(display_long)|uniprotkb:Phospholipase C-beta-2(gene name synonym)|uniprotkb:Plcb2(gene name)|psi-mi:Plcb2(display_short)|uniprotkb:Phosphoinositide phospholipase C-beta-2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688169	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031620.1|ensembl:ENSMUSG00000029767(gene)|ensembl:ENSMUST00000031779(transcript)|go:"GO:0004857"(enzyme inhibitor activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0019899"(enzyme binding)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0042470"(melanosome)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR027239|mint:O35887|reactome:R-MMU-381426|reactome:R-MMU-8957275	refseq:NP_001277719.1|refseq:NP_808236.2|ensembl:ENSMUSG00000040061(gene)|ensembl:ENSMUST00000102524(transcript)|go:"GO:0001580"(detection of chemical stimulus involved in sensory perception of bitter taste)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007200"(phospholipase C-activating G protein-coupled receptor signaling pathway)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0031680"(G-protein beta/gamma-subunit complex)|go:"GO:0031683"(G-protein beta/gamma-subunit complex binding)|go:"GO:0046488"(phosphatidylinositol metabolic process)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0050913"(sensory perception of bitter taste)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR011992(EF-Hand type)|interpro:IPR014815(PLC-beta, C-terminal)|interpro:IPR015359(Phospholipase C, phosphoinositol-specific, EF-hand-like)|interpro:IPR016280(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta)|interpro:IPR017946|interpro:IPR028403|interpro:IPR035892|interpro:IPR037862|reactome:R-MMU-112043|reactome:R-MMU-1855204|reactome:R-MMU-399997|reactome:R-MMU-4086398|reactome:R-MMU-416476|reactome:R-MMU-418217|reactome:R-MMU-434316|reactome:R-MMU-500657	afcs:21846(primary-reference)|afcs:13969(primary-reference)|afcs:13969(secondary-ac)	-	comment:afcs Y2H protein 21846. Translated from nucleotide sequence.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JSG2x2O/Lpg1JYjpePi+aqwSx+g10090	rogid:MH225dCuWXd8Xw3H1Kv/8ITyluQ10090	intact-crc:4E6ECA45B834FF09|rigid:/S3CkJi/PmGjuzxrFMurkorjLqo	false	sufficient binding region:168-315	sufficient binding region:660-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64727	uniprotkb:Q61210	intact:EBI-432047|uniprotkb:Q8BP32|uniprotkb:Q8BS46|uniprotkb:Q922C5|uniprotkb:Q922D9|ensembl:ENSMUSP00000022369	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:vinc_mouse(display_long)|uniprotkb:Metavinculin(gene name synonym)|uniprotkb:Vcl(gene name)|psi-mi:Vcl(display_short)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648805	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033528.3|ensembl:ENSMUSG00000021823(gene)|ensembl:ENSMUST00000022369(transcript)|go:"GO:0002009"(morphogenesis of an epithelium)|go:"GO:0002102"(podosome)|go:"GO:0002162"(dystroglycan binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0005916"(fascia adherens)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042383"(sarcolemma)|go:"GO:0043297"(apical junction assembly)|go:"GO:0044291"(cell-cell contact zone)|go:"GO:0045121"(membrane raft)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0048675"(axon extension)|go:"GO:0043034"(costamere)|go:"GO:0051015"(actin filament binding)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090636"(outer dense plaque of desmosome)|go:"GO:0090637"(inner dense plaque of desmosome)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1904702"(regulation of protein localization to adherens junction)|go:"GO:1990357"(terminal web)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR017997|interpro:IPR036723|mint:Q64727|rcsb pdb:5Y04|reactome:R-MMU-114608|reactome:R-MMU-445355|reactome:R-MMU-5674135|reactome:R-MMU-6798695	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:15548(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bfHsrHTLESS6CIctYpg0yX3N+UA10090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:DB417ACC93B7AA8E|rigid:C6kvJGvmSayKZHJR31yiIs19xm4	false	sufficient binding region:741-1048	sufficient binding region:591-920	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61039	uniprotkb:Q99N72	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	intact:EBI-641874	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648866	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:16151(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:996C05AC1D06230C|rigid:oMeB7lnkJZRX3/TyHvb/EmC9jaM	false	sufficient binding region:1-185	sufficient binding region:325-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61039	uniprotkb:Q99N72	intact:EBI-81388|ensembl:ENSMUSP00000044983|uniprotkb:Q61100	intact:EBI-641874	psi-mi:hand2_mouse(display_long)|uniprotkb:Hand2(gene name)|psi-mi:Hand2(display_short)|uniprotkb:Dhand(gene name synonym)|uniprotkb:Hed(gene name synonym)|uniprotkb:Thing2(gene name synonym)|uniprotkb:Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2(gene name synonym)|uniprotkb:Helix-loop-helix transcription factor expressed in embryo and deciduum(gene name synonym)|uniprotkb:Thing-2(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648887	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001947"(heart looping)|go:"GO:0001967"(suckling behavior)|ensembl:ENSMUSG00000038193(gene)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003215"(cardiac right ventricle morphogenesis)|ensembl:ENSMUST00000040104(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003219"(cardiac right ventricle formation)|go:"GO:0003253"(cardiac neural crest cell migration involved in outflow tract morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003278"(apoptotic process involved in heart morphogenesis)|go:"GO:0003680"(minor groove of adenine-thymine-rich DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007507"(heart development)|refseq:NP_034532.3|go:"GO:0060485"(mesenchyme development)|go:"GO:0060536"(cartilage morphogenesis)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0061032"(visceral serous pericardium development)|go:"GO:0043586"(tongue development)|go:"GO:0061309"(cardiac neural crest cell development involved in outflow tract morphogenesis)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048485"(sympathetic nervous system development)|go:"GO:0061325"(cell proliferation involved in outflow tract morphogenesis)|go:"GO:0048538"(thymus development)|go:"GO:0061371"(determination of heart left/right asymmetry)|go:"GO:0048935"(peripheral nervous system neuron development)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0060021"(roof of mouth development)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070888"(E-box binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903929"(primary palate development)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2000763"(positive regulation of transcription from RNA polymerase II promoter involved in norepinephrine biosynthetic process)|go:"GO:2000764"(positive regulation of semaphorin-plexin signaling pathway involved in outflow tract morphogenesis)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|go:"GO:0008134"(transcription factor binding)|go:"GO:0010463"(mesenchymal cell proliferation)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014032"(neural crest cell development)|go:"GO:0032502"(developmental process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034103"(regulation of tissue remodeling)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0007512"(adult heart development)	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:16151(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:u9+WSiaNOECbGxfa5igYrX0ZPGQ10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:5242899865469FAC|rigid:oMeB7lnkJZRX3/TyHvb/EmC9jaM	false	sufficient binding region:1-217	sufficient binding region:325-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:Q8CIH5	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648950	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:12352(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:3106A474BF072DE5|rigid:aXgA30jhaawG0MyOtwxBf+Cj2NY	false	sufficient binding region:548-850	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:Q8CIH5	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648970	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:12352(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:7A801D63C2FADB84|rigid:aXgA30jhaawG0MyOtwxBf+Cj2NY	false	sufficient binding region:596-860	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11276	uniprotkb:Q8CIH5	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649041	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:20361(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:323A888EB982BEF1|rigid:x/++3sbgbKrqW7GypmEYl9Px7Qk	false	sufficient binding region:585-1094	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11276	uniprotkb:Q8CIH5	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649061	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:20361(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:AE8D385DF9FF40D0|rigid:x/++3sbgbKrqW7GypmEYl9Px7Qk	false	sufficient binding region:767-1032	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11276	uniprotkb:Q8CIH5	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649071	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:20361(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:8DAD900B7EE2F3E9|rigid:x/++3sbgbKrqW7GypmEYl9Px7Qk	false	sufficient binding region:822-1032	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11276	uniprotkb:Q8CIH5	intact:EBI-641955|uniprotkb:G5E8B8|uniprotkb:Q61567|uniprotkb:Q61568|uniprotkb:Q61569|uniprotkb:Q64233|uniprotkb:Q80UI4|ensembl:ENSMUSP00000054499	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:finc_mouse(display_long)|uniprotkb:Fn1(gene name)|psi-mi:Fn1(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649081	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034363.1|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0006953"(acute-phase response)|go:"GO:0007044"(cell-substrate junction assembly)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008201"(heparin binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008347"(glial cell migration)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016504"(peptidase activator activity)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019899"(enzyme binding)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0033622"(integrin activation)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035987"(endodermal cell differentiation)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043394"(proteoglycan binding)|go:"GO:0045340"(mercury ion binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051087"(chaperone binding)|go:"GO:0051702"(biological process involved in interaction with symbiont)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070527"(platelet aggregation)|go:"GO:0071288"(cellular response to mercury ion)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071635"(negative regulation of transforming growth factor beta production)|go:"GO:0072378"(blood coagulation, fibrin clot formation)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:1901166"(neural crest cell migration involved in autonomic nervous system development)|go:"GO:1904237"(positive regulation of substrate-dependent cell migration, cell attachment to substrate)|interpro:IPR000083(Fibronectin, type I)|interpro:IPR000562(Type II fibronectin, collagen-binding)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013806(Kringle-like fold)|interpro:IPR036116|interpro:IPR036943|mint:P11276|rcsb pdb:1MFN|rcsb pdb:2MFN|reactome:R-MMU-114608|reactome:R-MMU-1474228|reactome:R-MMU-1474244|reactome:R-MMU-1566977|reactome:R-MMU-202733|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000170|reactome:R-MMU-3000171|reactome:R-MMU-3000178|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-381426|reactome:R-MMU-5674135|reactome:R-MMU-8874081|reactome:R-MMU-8957275|ensembl:ENSMUSG00000026193(gene)|ensembl:ENSMUST00000055226(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001775"(cell activation)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005577"(fibrinogen complex)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:20361(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qndGPG6vmzpIIkDuO1BrVRI1oPg10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:170F2FD5CBDD5154|rigid:x/++3sbgbKrqW7GypmEYl9Px7Qk	false	sufficient binding region:911-1032	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BTM8	uniprotkb:Q8CIH5	intact:EBI-641991|uniprotkb:B7FAV0|uniprotkb:O54934|uniprotkb:Q7TQI1|uniprotkb:Q8BLK1|uniprotkb:Q8BTN7|uniprotkb:Q8VHX5|uniprotkb:Q8VHX8|uniprotkb:Q99KQ2|ensembl:ENSMUSP00000033699	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:flna_mouse(display_long)|uniprotkb:Alpha-filamin(gene name synonym)|uniprotkb:Filamin-1(gene name synonym)|uniprotkb:Endothelial actin-binding protein(gene name synonym)|uniprotkb:Actin-binding protein 280(gene name synonym)|uniprotkb:Non-muscle filamin(gene name synonym)|uniprotkb:Flna(gene name)|psi-mi:Flna(display_short)|uniprotkb:Fln(gene name synonym)|uniprotkb:Fln1(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006527974.1|ensembl:ENSMUST00000033699(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007195"(adenylate cyclase-inhibiting dopamine receptor signaling pathway)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016479"(negative regulation of transcription by RNA polymerase I)|go:"GO:0019900"(kinase binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0021987"(cerebral cortex development)|ensembl:ENSMUSG00000031328(gene)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0046332"(SMAD binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0050808"(synapse organization)|go:"GO:0050821"(protein stabilization)|go:"GO:0051015"(actin filament binding)|go:"GO:0051020"(GTPase binding)|go:"GO:0051220"(cytoplasmic sequestering of protein)|go:"GO:0051764"(actin crosslink formation)|go:"GO:0060271"(cilium assembly)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090042"(tubulin deacetylation)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030863"(cortical cytoskeleton)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031523"(Myb complex)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031852"(mu-type opioid receptor binding)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032233"(positive regulation of actin filament bundle assembly)|go:"GO:0032432"(actin filament bundle)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034988"(Fc-gamma receptor I complex binding)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043113"(receptor clustering)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043204"(perikaryon)|go:"GO:0097440"(apical dendrite)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901381"(positive regulation of potassium ion transmembrane transport)|go:"GO:1902396"(protein localization to bicellular tight junction)|go:"GO:1905000"(regulation of membrane repolarization during atrial cardiac muscle cell action potential)|go:"GO:1905031"(regulation of membrane repolarization during cardiac muscle cell action potential)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001046"(positive regulation of integrin-mediated signaling pathway)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|go:"GO:0097368"(establishment of Sertoli cell barrier)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR036872|interpro:IPR044801|mint:Q8BTM8|reactome:R-MMU-114608|reactome:R-MMU-430116|reactome:R-MMU-446353|reactome:R-MMU-5627123	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:21359(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hp3whHs7nFMTtChpQ/KywkPalq810090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:0ED58A9ED181C4CE|rigid:g5G1GEKzMJq9mZe7ytj9rPc+kf0	false	sufficient binding region:1594-2166	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CIH5	uniprotkb:Q62158	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	intact:EBI-642025|uniprotkb:Q62157|uniprotkb:Q8C2Q5|uniprotkb:Q99LK1|ensembl:ENSMUSP00000021761|ensembl:ENSMUSP00000152730	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:tri27_mouse(display_long)|uniprotkb:Ret finger protein(gene name synonym)|uniprotkb:Tripartite motif-containing protein 27(gene name synonym)|uniprotkb:Trim27(gene name)|psi-mi:Trim27(display_short)|uniprotkb:Rfp(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRIM27(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649152	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	refseq:NP_033080.2|refseq:XP_006516669.1|go:"GO:0019901"(protein kinase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0034314"(Arp2/3 complex-mediated actin nucleation)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045087"(innate immune response)|go:"GO:0045814"(negative regulation of gene expression, epigenetic)|go:"GO:0046596"(regulation of viral entry into host cell)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0016605"(PML body)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051127"(positive regulation of actin nucleation)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0090281"(negative regulation of calcium ion import)|go:"GO:1902187"|interpro:IPR000315(Zinc finger, B-box)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR003879(Butyrophylin-like)|interpro:IPR006574(SPRY-associated)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR017907|interpro:IPR020457|interpro:IPR035791|interpro:IPR043136|mint:Q62158|reactome:R-MMU-3232142|reactome:R-MMU-8948751|ensembl:ENSMUSG00000021326(gene)|ensembl:ENSMUST00000021761(transcript)|ensembl:ENSMUST00000222544(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001650"(fibrillar center)|go:"GO:0002820"(negative regulation of adaptive immune response)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010468"(regulation of gene expression)	afcs:22821(primary-reference)|afcs:15182(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	rogid:ay3vOvfbC0rFrDbLB0NsvrT9eBw10090	intact-crc:AF7BAB0671EED518|rigid:MBpHTSCNayiq3GPwOCKBdGFtaKQ	false	sufficient binding region:450-835	sufficient binding region:1-151	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R1V7-1	uniprotkb:E9PZQ0	intact:EBI-642185|ensembl:ENSMUSP00000084633	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:q9r1v7-1(display_long)|uniprotkb:Adam23(gene name)|psi-mi:Adam23(display_short)|uniprotkb:Mdc3(gene name synonym)|uniprotkb:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649329	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-642169(ada23_mouse)|ensembl:ENSMUSG00000025964(gene)|ensembl:ENSMUST00000087374(transcript)	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:16978(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Im2FK3zBdAvSUbBdOZo2hsEQQ8U10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:08296986A7BC0684|rigid:QYvDvXWMKNUFKfLIXr1oxGdYANE	false	sufficient binding region:669-829	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40124	uniprotkb:Q99N72	intact:EBI-641927|intact:EBI-2308504|uniprotkb:Q8BPT7|ensembl:ENSMUSP00000068260|ensembl:ENSMUSP00000101862|ensembl:ENSMUSP00000101864	intact:EBI-641874	psi-mi:cap1_mouse(display_long)|uniprotkb:Cap1(gene name)|psi-mi:Cap1(display_short)|uniprotkb:Cap(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649381	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287996.1|refseq:NP_031624.2|refseq:XP_006502758.1|refseq:XP_006502760.1|ensembl:ENSMUSG00000028656(gene)|ensembl:ENSMUST00000069533(transcript)|ensembl:ENSMUST00000106255(transcript)|ensembl:ENSMUST00000106257(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045761"(regulation of adenylate cyclase activity)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP,  C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028415|interpro:IPR028417|interpro:IPR036222|interpro:IPR036223|mint:P40124|rcsb pdb:6FM2|rcsb pdb:6RSQ|rcsb pdb:6RSW|reactome:R-MMU-6798695|dip:DIP-49641N	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:6230(secondary-ac)	-	-	caution:The prey construct contains 14 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Qgj2tTTmQRMu8qVRerwwxesJu/810090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:7E40D0D406293F48|rigid:IqQz6/QQJWk21Pi5Z6CGcSWA3Lk	false	sufficient binding region:2-284	sufficient binding region:325-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40124	uniprotkb:Q99N72	intact:EBI-641927|intact:EBI-2308504|uniprotkb:Q8BPT7|ensembl:ENSMUSP00000068260|ensembl:ENSMUSP00000101862|ensembl:ENSMUSP00000101864	intact:EBI-641874	psi-mi:cap1_mouse(display_long)|uniprotkb:Cap1(gene name)|psi-mi:Cap1(display_short)|uniprotkb:Cap(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649391	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287996.1|refseq:NP_031624.2|refseq:XP_006502758.1|refseq:XP_006502760.1|ensembl:ENSMUSG00000028656(gene)|ensembl:ENSMUST00000069533(transcript)|ensembl:ENSMUST00000106255(transcript)|ensembl:ENSMUST00000106257(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045761"(regulation of adenylate cyclase activity)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP,  C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028415|interpro:IPR028417|interpro:IPR036222|interpro:IPR036223|mint:P40124|rcsb pdb:6FM2|rcsb pdb:6RSQ|rcsb pdb:6RSW|reactome:R-MMU-6798695|dip:DIP-49641N	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:6230(secondary-ac)	-	-	caution:The prey construct contains 8 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Qgj2tTTmQRMu8qVRerwwxesJu/810090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:9733FA7041D18611|rigid:IqQz6/QQJWk21Pi5Z6CGcSWA3Lk	false	sufficient binding region:2-263	sufficient binding region:325-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P40124	uniprotkb:Q99N72	intact:EBI-641927|intact:EBI-2308504|uniprotkb:Q8BPT7|ensembl:ENSMUSP00000068260|ensembl:ENSMUSP00000101862|ensembl:ENSMUSP00000101864	intact:EBI-641874	psi-mi:cap1_mouse(display_long)|uniprotkb:Cap1(gene name)|psi-mi:Cap1(display_short)|uniprotkb:Cap(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649402	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001287996.1|refseq:NP_031624.2|refseq:XP_006502758.1|refseq:XP_006502760.1|ensembl:ENSMUSG00000028656(gene)|ensembl:ENSMUST00000069533(transcript)|ensembl:ENSMUST00000106255(transcript)|ensembl:ENSMUST00000106257(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0003779"(actin binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019933"(cAMP-mediated signaling)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0045761"(regulation of adenylate cyclase activity)|interpro:IPR001837(Adenylate cyclase-associated CAP)|interpro:IPR006599(CARP motif)|interpro:IPR013912(Adenylate cyclase-associated CAP,  C-terminal)|interpro:IPR013992(Adenylate cyclase-associated CAP, N-terminal)|interpro:IPR016098(Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal)|interpro:IPR017901|interpro:IPR018106|interpro:IPR028415|interpro:IPR028417|interpro:IPR036222|interpro:IPR036223|mint:P40124|rcsb pdb:6FM2|rcsb pdb:6RSQ|rcsb pdb:6RSW|reactome:R-MMU-6798695|dip:DIP-49641N	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:6230(secondary-ac)	-	-	caution:The prey construct contains 5 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Qgj2tTTmQRMu8qVRerwwxesJu/810090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:D8A4E628E19CAB30|rigid:IqQz6/QQJWk21Pi5Z6CGcSWA3Lk	false	sufficient binding region:2-256	sufficient binding region:325-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63082	uniprotkb:Q9Z2A0	intact:EBI-642254|uniprotkb:P23967|uniprotkb:Q3TD69|ensembl:ENSMUSP00000024932|ensembl:ENSMUSP00000111059	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:vatl_mouse(display_long)|uniprotkb:PL16(gene name synonym)|uniprotkb:Atp6v0c(gene name)|psi-mi:Atp6v0c(display_short)|uniprotkb:Atp6c(gene name synonym)|uniprotkb:Atp6l(gene name synonym)|uniprotkb:Atpl(gene name synonym)|uniprotkb:Mvp(gene name synonym)|uniprotkb:Vacuolar proton pump 16 kDa proteolipid subunit(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649475	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033859.1|ensembl:ENSMUSG00000024121(gene)|ensembl:ENSMUST00000024932(transcript)|ensembl:ENSMUST00000098862(transcript)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0046961"(proton-transporting ATPase activity, rotational mechanism)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:1904093"(negative regulation of autophagic cell death)|interpro:IPR000245(ATPase, V0 complex, proteolipid subunit C,)|interpro:IPR002379(ATPase, F0/V0 complex, subunit C)|interpro:IPR011555(ATPase, V0 complex, proteolipid subunit C, eukaryotic)|interpro:IPR035921|reactome:R-MMU-1222556|reactome:R-MMU-6798695|reactome:R-MMU-77387|reactome:R-MMU-917977|reactome:R-MMU-9639288|reactome:R-MMU-983712|go:"GO:0008553"(P-type proton-exporting transporter activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016471"(vacuolar proton-transporting V-type ATPase complex)|go:"GO:0030177"(positive regulation of Wnt signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033179"(proton-transporting V-type ATPase, V0 domain)	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:15710(secondary-ac)	-	-	caution:The prey construct contains 10 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Qx4BtXXIXdTlTTWE3nBHM8kThHU10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:0BD3E66A54E64476|rigid:U8jTvo7UeA/WJYiuakQTGQvUGJU	false	sufficient binding region:1-155	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35607	uniprotkb:Q8BWG8	intact:EBI-527224|ensembl:ENSMUSP00000084701	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:bmpr2_mouse(display_long)|uniprotkb:Bone morphogenetic protein receptor type II(gene name synonym)|uniprotkb:BRK-3(gene name synonym)|uniprotkb:Bmpr2(gene name)|psi-mi:Bmpr2(display_short)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649496	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000067336(gene)|ensembl:ENSMUST00000087435(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001893"(maternal placenta development)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0001946"(lymphangiogenesis)|go:"GO:0001974"(blood vessel remodeling)|go:"GO:0002063"(chondrocyte development)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0003148"(outflow tract septum morphogenesis)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003183"(mitral valve morphogenesis)|go:"GO:0003186"(tricuspid valve morphogenesis)|go:"GO:0003197"(endocardial cushion development)|go:"GO:0003252"(negative regulation of cell proliferation involved in heart valve morphogenesis)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005024"(transforming growth factor beta-activated receptor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007420"(brain development)|go:"GO:0009267"(cellular response to starvation)|refseq:NP_031587.1|go:"GO:0009925"(basal plasma membrane)|go:"GO:0009952"(anterior/posterior pattern specification)|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0010862"(positive regulation of pathway-restricted SMAD protein phosphorylation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014916"(regulation of lung blood pressure)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019211"(phosphatase activator activity)|go:"GO:0019838"(growth factor binding)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030425"(dendrite)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030513"(positive regulation of BMP signaling pathway)|go:"GO:0030546"(signaling receptor activator activity)|go:"GO:0036122"(BMP binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043235"(receptor complex)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045296"(cadherin binding)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045906"(negative regulation of vasoconstriction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0048842"(positive regulation of axon extension involved in axon guidance)|go:"GO:0051148"(negative regulation of muscle cell differentiation)|go:"GO:0060173"(limb development)|go:"GO:0060350"(endochondral bone morphogenesis)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060412"(ventricular septum morphogenesis)|go:"GO:0060413"(atrial septum morphogenesis)|go:"GO:0060836"(lymphatic endothelial cell differentiation)|go:"GO:0060840"(artery development)|go:"GO:0060841"(venous blood vessel development)|go:"GO:0061036"(positive regulation of cartilage development)|go:"GO:0061298"(retina vasculature development in camera-type eye)|go:"GO:0061626"(pharyngeal arch artery morphogenesis)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071773"(cellular response to BMP stimulus)|go:"GO:0072577"(endothelial cell apoptotic process)|go:"GO:0098821"(BMP receptor activity)|go:"GO:0140537"(transcription regulator activator activity)|go:"GO:1902731"(negative regulation of chondrocyte proliferation)|go:"GO:1905314"(semi-lunar valve development)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000279"(negative regulation of DNA biosynthetic process)|interpro:IPR000472(TGF-beta receptor/activin receptor, type I/II)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000333(Activin type II receptor)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015770(Bone morphogenic protein type II receptor)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:O35607|reactome:R-MMU-201451	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:13944(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4Dbgj6TEhtrX/9jydmufYNfEh1M10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:7DC2EE1617B67C38|rigid:b1Ew6ATi7xapz9k24opmZwG6Vyo	false	sufficient binding region:540-667	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VBU8	uniprotkb:Q9QUN3	intact:EBI-642296|uniprotkb:O88973|uniprotkb:Q3U4R5|uniprotkb:Q91YZ1|uniprotkb:Q9ES51|ensembl:ENSMUSP00000132095	intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844	psi-mi:banp_mouse(display_long)|uniprotkb:Btg3-associated nuclear protein(gene name synonym)|uniprotkb:Scaffold/matrix-associated region-1-binding protein(gene name synonym)|uniprotkb:Banp(gene name)|psi-mi:Banp(display_short)|uniprotkb:Smar1(gene name synonym)	psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649518	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272910.1|refseq:NP_001272912.1|refseq:NP_001103570.1|refseq:NP_058092.2|refseq:XP_011246744.1|ensembl:ENSMUSG00000025316(gene)|ensembl:ENSMUST00000170857(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR018379|interpro:IPR042343|reactome:R-MMU-6804759|refseq:XP_017168388.1	refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)	afcs:21969(primary-reference)|afcs:23672(secondary-ac)	-	-	caution:The prey construct contains 45 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:lq96lxe+A2PbfKUt/PiZeiWCKq810090	rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090	intact-crc:785551E62F390E5A|rigid:V4l4mvjK2zdlJg8nbFBzbe+iPGA	false	sufficient binding region:1-509	sufficient binding region:348-457	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VBU8	uniprotkb:Q9QUN3	intact:EBI-642296|uniprotkb:O88973|uniprotkb:Q3U4R5|uniprotkb:Q91YZ1|uniprotkb:Q9ES51|ensembl:ENSMUSP00000132095	intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844	psi-mi:banp_mouse(display_long)|uniprotkb:Btg3-associated nuclear protein(gene name synonym)|uniprotkb:Scaffold/matrix-associated region-1-binding protein(gene name synonym)|uniprotkb:Banp(gene name)|psi-mi:Banp(display_short)|uniprotkb:Smar1(gene name synonym)	psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649530	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272910.1|refseq:NP_001272912.1|refseq:NP_001103570.1|refseq:NP_058092.2|refseq:XP_011246744.1|ensembl:ENSMUSG00000025316(gene)|ensembl:ENSMUST00000170857(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)|go:"GO:0016604"(nuclear body)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR018379|interpro:IPR042343|reactome:R-MMU-6804759|refseq:XP_017168388.1	refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)	afcs:21969(primary-reference)|afcs:23672(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:lq96lxe+A2PbfKUt/PiZeiWCKq810090	rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090	intact-crc:E0870B980FE4CD8C|rigid:V4l4mvjK2zdlJg8nbFBzbe+iPGA	false	sufficient binding region:117-330	sufficient binding region:348-457	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61210	uniprotkb:P53564	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	intact:EBI-642309|uniprotkb:O08994|uniprotkb:P70301|uniprotkb:Q571L6|uniprotkb:Q91ZD2	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:cux1_mouse(display_long)|uniprotkb:CCAAT displacement protein(gene name synonym)|uniprotkb:Homeobox protein cux-1(gene name synonym)|uniprotkb:Kiaa4047(gene name synonym)|uniprotkb:Cux1(gene name)|psi-mi:Cux1(display_short)|uniprotkb:Cux(gene name synonym)|uniprotkb:Cutl1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649550	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	interpro:IPR003350(Homeodomain protein CUT)|interpro:IPR001356(Homeobox)|interpro:IPR017970|interpro:IPR009057(Homeodomain-like)|interpro:IPR010982(Lambda repressor-like, DNA-binding)|mint:P53564|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001822"(kidney development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030324"(lung development)|go:"GO:0042491"(inner ear auditory receptor cell differentiation)|go:"GO:0043005"(neuron projection)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|refseq:NP_001278162.1|refseq:NP_001278163.1|refseq:NP_034116.3	afcs:14722(primary-reference)|afcs:15884(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	rogid:XozohEVVgGk0JJ5Qaw2AmPO+dHI10090	intact-crc:BC458B1D1F185279|rigid:Eobq3Ffuc0Wwzl9adpZydkLFXBw	false	sufficient binding region:591-920	sufficient binding region:177-286	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1D1	uniprotkb:Q9JL25	intact:EBI-642408|uniprotkb:Q9R079|ensembl:ENSMUSP00000004206	intact:EBI-642400|uniprotkb:Q3TBD1|uniprotkb:Q3TC18|uniprotkb:Q3TD56|uniprotkb:Q3U477|ensembl:ENSMUSP00000140624	psi-mi:eif3g_mouse(display_long)|uniprotkb:Eif3s4(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 subunit 4(gene name synonym)|uniprotkb:eIF-3-delta(gene name synonym)|uniprotkb:Eukaryotic translation initiation factor 3 RNA-binding subunit(gene name synonym)|uniprotkb:eIF3 p44(gene name synonym)|uniprotkb:eIF3 p42(gene name synonym)|uniprotkb:Eif3g(gene name)|psi-mi:Eif3g(display_short)|uniprotkb:Eif3p42(gene name synonym)	psi-mi:rgs1_mouse(display_long)|uniprotkb:Rgs1(gene name)|psi-mi:Rgs1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649611	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058572.2|ensembl:ENSMUSG00000070319(gene)|ensembl:ENSMUST00000004206(transcript)|go:"GO:0001732"(formation of cytoplasmic translation initiation complex)|go:"GO:0003723"(RNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005852"(eukaryotic translation initiation factor 3 complex)|go:"GO:0006413"(translational initiation)|go:"GO:0016282"(eukaryotic 43S preinitiation complex)|go:"GO:0033290"(eukaryotic 48S preinitiation complex)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0075525"(viral translational termination-reinitiation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR017334(Translation initiation factor 3, RNA-binding subunit)|interpro:IPR024675|interpro:IPR034240|interpro:IPR035979|mint:Q9Z1D1|reactome:R-MMU-156827|reactome:R-MMU-72649|reactome:R-MMU-72689|reactome:R-MMU-72695|reactome:R-MMU-72702|reactome:R-MMU-72706	refseq:NP_056626.2|reactome:R-MMU-416476|reactome:R-MMU-418594|interpro:IPR036305|ensembl:ENSMUSG00000026358(gene)|ensembl:ENSMUST00000189061(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0061737"(leukotriene signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR030409	afcs:17628(primary-reference)|afcs:17792(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Tg6eCPZZkVgKsOicPmasuzr8gYs10090	rogid:tkOVK7JJ2n/5EyhCM6ChMjMWv6410090	intact-crc:D6984CA29A623FEE|rigid:wuoysDN/yfHgHw1fKz1jRb9V74w	false	sufficient binding region:7-193	sufficient binding region:14-113	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P29391	uniprotkb:P35991	intact:EBI-309285|uniprotkb:Q8WUQ8	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:fril1_mouse(display_long)|uniprotkb:Ftl1(gene name)|psi-mi:Ftl1(display_short)|uniprotkb:Ftl(gene name synonym)|uniprotkb:Ftl-1(gene name synonym)|uniprotkb:Ferritin L subunit 1(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649622	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001519(Ferritin, N-terminal)|interpro:IPR009040(Ferritin-like)|interpro:IPR012347(Ferritin-related)|interpro:IPR009078(Ferritin/ribonucleotide reductase-like)|interpro:IPR014034(Ferritin, conserved site)|interpro:IPR008331(Ferritin and Dps)|rcsb pdb:1H96|rcsb pdb:1LB3|go:"GO:0005506"(iron ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0006826"(iron ion transport)|go:"GO:0006880"(intracellular sequestering of iron ion)|go:"GO:0008043"(intracellular ferritin complex)|go:"GO:0008198"(ferrous iron binding)|go:"GO:0008199"(ferric iron binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044754"(autolysosome)|go:"GO:0071682"(endocytic vesicle lumen)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:16036(secondary-ac)	-	-	caution:The prey construct contains 58 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:9LMyVftFjQVCxzUakUZ7W3L5Pig10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:991020261C813677|rigid:AXwDVMyOjDlf43LOyk7ucQD8h1U	false	sufficient binding region:2-183	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JI19	uniprotkb:Q91YD9	intact:EBI-642430|ensembl:ENSMUSP00000153409	intact:EBI-642417|ensembl:ENSMUSP00000031695	psi-mi:fibp_mouse(display_long)|uniprotkb:FGF-1 intracellular-binding protein(gene name synonym)|uniprotkb:Fibp(gene name)|psi-mi:Fibp(display_short)	psi-mi:wasl_mouse(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649633	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067413.1|ensembl:ENSMUSG00000024911(gene)|ensembl:ENSMUST00000225141(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0016607"(nuclear speck)|go:"GO:0017134"(fibroblast growth factor binding)|interpro:IPR008614(Acidic fibroblast growth factor binding)	refseq:NP_082735.2|ensembl:ENSMUSG00000029684(gene)|ensembl:ENSMUST00000031695(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010324"(membrane invagination)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045010"(actin nucleation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:Q91YD9|rcsb pdb:3M3N|rcsb pdb:6UHC|dip:DIP-29788N	afcs:21850(primary-reference)|afcs:23936(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/90IGQwoO9AouDFLKewtqHflLAI10090	rogid:TXI8wfugOptN0kVS3yEJxaM4uq810090	intact-crc:4AAFE7F7294C7C54|rigid:wg8UR3ovrww8yU9ITlTYL2PpAdE	false	sufficient binding region:1-357	sufficient binding region:1-210	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P98192	uniprotkb:Q8BWG8	intact:EBI-309820|uniprotkb:Q9WUT6|ensembl:ENSMUSP00000034466	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:gnpat_mouse(display_long)|uniprotkb:Gnpat(gene name)|psi-mi:Gnpat(display_short)|uniprotkb:Dhapat(gene name synonym)|uniprotkb:Glycerone-phosphate O-acyltransferase(gene name synonym)|uniprotkb:"Acyl-CoA:dihydroxyacetonephosphateacyltransferase"(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649686	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034452.3|ensembl:ENSMUSG00000031985(gene)|ensembl:ENSMUST00000034466(transcript)|go:"GO:0003824"(catalytic activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0005778"(peroxisomal membrane)|go:"GO:0005782"(peroxisomal matrix)|go:"GO:0006631"(fatty acid metabolic process)|go:"GO:0006650"(glycerophospholipid metabolic process)|go:"GO:0007416"(synapse assembly)|go:"GO:0007584"(response to nutrient)|go:"GO:0008611"(ether lipid biosynthetic process)|go:"GO:0008654"(phospholipid biosynthetic process)|go:"GO:0016287"(glycerone-phosphate O-acyltransferase activity)|go:"GO:0021587"(cerebellum morphogenesis)|go:"GO:0030913"(paranodal junction assembly)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0042493"|go:"GO:0042552"(myelination)|go:"GO:0042594"(response to starvation)|go:"GO:0061024"(membrane organization)|go:"GO:0070542"(response to fatty acid)|interpro:IPR002123(Phospholipid/glycerol acyltransferase)|interpro:IPR022284|interpro:IPR028353|interpro:IPR041728|reactome:R-MMU-75896|reactome:R-MMU-9033241|reactome:R-MMU-1483166	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:16093(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:XdKIe7B174/MwXMe4LYXakpsLqk10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:3B3CD9791A997896|rigid:u4IdhYYY5unpbr4twRL1o2AK9ro	false	sufficient binding region:347-672	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0C0S6	uniprotkb:P35991	intact:EBI-642131|uniprotkb:P17317|uniprotkb:Q3UA55|uniprotkb:Q3UK43|uniprotkb:Q68FD2|uniprotkb:B2RXZ3|ensembl:ENSMUSP00000036907	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:h2az_mouse(display_long)|uniprotkb:H2az1(gene name)|psi-mi:H2az1(display_short)|uniprotkb:H2afz(gene name synonym)|uniprotkb:H2az(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649698	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058030.1|ensembl:ENSMUSG00000037894(gene)|ensembl:ENSMUST00000041045(transcript)|go:"GO:0000786"(nucleosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000792"(heterochromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006342"|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031492"(nucleosomal DNA binding)|reactome:R-MMU-606279|reactome:R-MMU-73728|reactome:R-MMU-73772|reactome:R-MMU-8936459|reactome:R-MMU-9018519|reactome:R-MMU-9670095|reactome:R-MMU-5625886|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0071392"(cellular response to estradiol stimulus)|interpro:IPR002119(Histone H2A)|interpro:IPR007125(Histone core)|interpro:IPR009072(Histone-fold)|interpro:IPR032454|interpro:IPR032458|mint:P0C0S6|reactome:R-MMU-110330|reactome:R-MMU-110331|reactome:R-MMU-212300|reactome:R-MMU-2299718|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559586|reactome:R-MMU-427359|reactome:R-MMU-427413|go:"GO:0032869"(cellular response to insulin stimulus)|reactome:R-MMU-5250924|reactome:R-MMU-5578749	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:17709(secondary-ac)	-	-	caution:The prey construct contains 24 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0FrzM1TXlduSQ0NNVl0C9uqCUGI10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:2C7142F6734F2CF4|rigid:lWLUy/u8yYC7Y1369ksntKgDgjQ	false	sufficient binding region:1-128	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:Q8BWG8	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649709	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:FA159C48291DDBC1|rigid:jbF69OubAfrWvihbeLD0WRdjIUw	false	sufficient binding region:44-280	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K2T8	uniprotkb:Q9Z2A0	intact:EBI-642477|uniprotkb:Q3UY97|uniprotkb:Q9CS63|uniprotkb:Q9JJ99|ensembl:ENSMUSP00000003529	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:paf1_mouse(display_long)|uniprotkb:Paf1(gene name)|psi-mi:Paf1(display_short)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649810	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062331.2|ensembl:ENSMUSG00000003437(gene)|ensembl:ENSMUST00000003529(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0003682"(chromatin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016020"(membrane)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016584"(nucleosome positioning)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0030054"(cell junction)|go:"GO:0031062"(positive regulation of histone methylation)|go:"GO:0031442"(positive regulation of mRNA 3'-end processing)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0035327"|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|interpro:IPR007133(RNA polymerase II-associated, Paf1)|mint:Q8K2T8|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-75955|reactome:R-MMU-8866654	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:23684(secondary-ac)	-	-	caution:The prey construct contains 73 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1cFGAVgb19bf33BaPcIowpXT5qc10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:B9688849D7FA37DB|rigid:qwuRB+rKETpP/Cj4lU6JwoTQR1g	false	sufficient binding region:1-181	sufficient binding region:2-101	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54946	uniprotkb:Q8BWG8	intact:EBI-642500|uniprotkb:Q3TE94|uniprotkb:Q3U6L0|uniprotkb:Q3UNJ5|uniprotkb:Q3UYT7|uniprotkb:Q99LA5|uniprotkb:Q9QYI9|ensembl:ENSMUSP00000008733	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:dnjb6_mouse(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MRJ(gene name synonym)|uniprotkb:mDj4(gene name synonym)|uniprotkb:Dnajb6(gene name)|psi-mi:Dnajb6(display_short)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Mrj(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649862	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033029.1|refseq:NP_001120839.1|refseq:NP_035977.2|ensembl:ENSMUSG00000029131(gene)|ensembl:ENSMUST00000008733(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O54946|reactome:R-MMU-3371453	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:17032(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Snii+B7COng2Zkduai/v24f83bw10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:766967695D4F8816|rigid:A3HN9iRDPZDR2WHK9VTbgF4GC7w	false	sufficient binding region:28-242	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54946	uniprotkb:Q8BWG8	intact:EBI-642500|uniprotkb:Q3TE94|uniprotkb:Q3U6L0|uniprotkb:Q3UNJ5|uniprotkb:Q3UYT7|uniprotkb:Q99LA5|uniprotkb:Q9QYI9|ensembl:ENSMUSP00000008733	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:dnjb6_mouse(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MRJ(gene name synonym)|uniprotkb:mDj4(gene name synonym)|uniprotkb:Dnajb6(gene name)|psi-mi:Dnajb6(display_short)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Mrj(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649872	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033029.1|refseq:NP_001120839.1|refseq:NP_035977.2|ensembl:ENSMUSG00000029131(gene)|ensembl:ENSMUST00000008733(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O54946|reactome:R-MMU-3371453	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:17032(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Snii+B7COng2Zkduai/v24f83bw10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:29EB72B1626DFA52|rigid:A3HN9iRDPZDR2WHK9VTbgF4GC7w	false	sufficient binding region:32-242	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54946	uniprotkb:Q8BWG8	intact:EBI-642500|uniprotkb:Q3TE94|uniprotkb:Q3U6L0|uniprotkb:Q3UNJ5|uniprotkb:Q3UYT7|uniprotkb:Q99LA5|uniprotkb:Q9QYI9|ensembl:ENSMUSP00000008733	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:dnjb6_mouse(display_long)|uniprotkb:Heat shock protein J2(gene name synonym)|uniprotkb:MRJ(gene name synonym)|uniprotkb:mDj4(gene name synonym)|uniprotkb:Dnajb6(gene name)|psi-mi:Dnajb6(display_short)|uniprotkb:Hsj2(gene name synonym)|uniprotkb:Mrj(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649902	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033029.1|refseq:NP_001120839.1|refseq:NP_035977.2|ensembl:ENSMUSG00000029131(gene)|ensembl:ENSMUST00000008733(transcript)|go:"GO:0001671"(ATPase activator activity)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006457"(protein folding)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0042802"(identical protein binding)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044183"(protein folding chaperone)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0060710"(chorio-allantoic fusion)|go:"GO:0060715"(syncytiotrophoblast cell differentiation involved in labyrinthine layer development)|go:"GO:0060717"(chorion development)|go:"GO:0061077"(chaperone-mediated protein folding)|go:"GO:0090084"(negative regulation of inclusion body assembly)|interpro:IPR001623(Heat shock protein DnaJ, N-terminal)|interpro:IPR018253|interpro:IPR036869|mint:O54946|reactome:R-MMU-3371453	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:17032(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Snii+B7COng2Zkduai/v24f83bw10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:4F62EE74101BB9F7|rigid:A3HN9iRDPZDR2WHK9VTbgF4GC7w	false	sufficient binding region:97-242	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08746	uniprotkb:Q8BWG8	intact:EBI-642537|uniprotkb:E9QPK9|uniprotkb:Q8R542|ensembl:ENSMUSP00000154040	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:matn2_mouse(display_long)|uniprotkb:Matn2(gene name)|psi-mi:Matn2(display_short)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649932	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006520086.1|ensembl:ENSMUSG00000022324(gene)|ensembl:ENSMUST00000227759(transcript)|go:"GO:0001764"(neuron migration)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0007411"(axon guidance)|go:"GO:0008347"(glial cell migration)|go:"GO:0031012"(extracellular matrix)|go:"GO:0031104"(dendrite regeneration)|go:"GO:0031175"(neuron projection development)|go:"GO:0048678"(response to axon injury)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002035(von Willebrand factor, type A)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR019466|interpro:IPR030747|interpro:IPR036337|interpro:IPR036465|go:"GO:0062023"(collagen-containing extracellular matrix)	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:17721(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:eIx5dU8z6JnTeUXBbK/QKdTHw0A10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:FE1F9D95D5313DB7|rigid:dzx2i4VaDRKdnqevuFK9Izy5UnU	false	sufficient binding region:858-956	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60795	uniprotkb:Q8BWG8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649963	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:16462(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:A9925EABC7E7039F|rigid:xYUSnEAjz+gYAvVzCnf4/GoMdvM	false	sufficient binding region:12-597	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60795	uniprotkb:Q8BWG8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649973	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:16462(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:82CFF7031E55C7D0|rigid:xYUSnEAjz+gYAvVzCnf4/GoMdvM	false	sufficient binding region:100-503	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60795	uniprotkb:Q8BWG8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649983	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:16462(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:2DA7E019E2D4A819|rigid:xYUSnEAjz+gYAvVzCnf4/GoMdvM	false	sufficient binding region:124-386	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60795	uniprotkb:Q8BWG8	intact:EBI-642563|uniprotkb:Q3UQK0|ensembl:ENSMUSP00000099733	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:nf2l2_mouse(display_long)|uniprotkb:Nuclear factor, erythroid derived 2, like 2(gene name synonym)|uniprotkb:Nfe2l2(gene name)|psi-mi:Nfe2l2(display_short)|uniprotkb:Nrf2(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649993	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035032.1|ensembl:ENSMUSG00000015839(gene)|ensembl:ENSMUST00000102672(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010226"(response to lithium ion)|go:"GO:0010499"(proteasomal ubiquitin-independent protein catabolic process)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030194"(positive regulation of blood coagulation)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035690"|go:"GO:0036003"(positive regulation of transcription from RNA polymerase II promoter in response to stress)|go:"GO:0036091"(positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress)|go:"GO:0036499"(PERK-mediated unfolded protein response)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0046223"(aflatoxin catabolic process)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061419"(positive regulation of transcription from RNA polymerase II promoter in response to hypoxia)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0071499"(cellular response to laminar fluid shear stress)|go:"GO:1902037"(negative regulation of hematopoietic stem cell differentiation)|go:"GO:1902176"(negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903788"(positive regulation of glutathione biosynthetic process)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:2000121"(regulation of removal of superoxide radicals)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR004826(Maf transcription factor)|interpro:IPR004827("Basic-leucine zipper (bZIP) transcription factor")|interpro:IPR008917(Eukaryotic transcription factor, Skn-1-like, DNA-binding)|interpro:IPR029845|rcsb pdb:1X2R|rcsb pdb:2DYH|rcsb pdb:3WN7|reactome:R-MMU-8932339|dip:DIP-49666N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:16462(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:flFH5+oCBXzNgfBzUiwuHtDQla810090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:81C47A4840E15BCB|rigid:xYUSnEAjz+gYAvVzCnf4/GoMdvM	false	sufficient binding region:240-590	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88643	uniprotkb:Q9ES28	intact:EBI-457240	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650013	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	afcs:17882(primary-reference)|afcs:16524(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	intact-crc:00C0E8DD2EDA377F|rigid:R8ahu6iU/fW5QvI5J9vDGhoDroo	false	sufficient binding region:36-232	sufficient binding region:1-100	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88531	uniprotkb:Q9Z2A0	intact:EBI-642605|uniprotkb:Q9D681|uniprotkb:Q9WTY3|ensembl:ENSMUSP00000030412	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:ppt1_mouse(display_long)|uniprotkb:Palmitoyl-protein hydrolase 1(gene name synonym)|uniprotkb:Ppt1(gene name)|psi-mi:Ppt1(display_short)|uniprotkb:Ppt(gene name synonym)|uniprotkb:Cln1(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650024	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032943.2|go:"GO:0002084"(protein depalmitoylation)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006898"(receptor-mediated endocytosis)|ensembl:ENSMUSG00000028657(gene)|go:"GO:0006907"(pinocytosis)|ensembl:ENSMUST00000030412(transcript)|go:"GO:0007040"(lysosome organization)|go:"GO:0007042"(lysosomal lumen acidification)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007399"(nervous system development)|go:"GO:0007420"(brain development)|go:"GO:0007601"(visual perception)|go:"GO:0007625"(grooming behavior)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0008344"(adult locomotory behavior)|go:"GO:0008474"("palmitoyl-(protein) hydrolase activity")|go:"GO:0015031"(protein transport)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016290"(palmitoyl-CoA hydrolase activity)|go:"GO:0016790"(thiolester hydrolase activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031579"(membrane raft organization)|go:"GO:0035727"(lysophosphatidic acid binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044257"(cellular protein catabolic process)|go:"GO:0044265"(cellular macromolecule catabolic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0048260"(positive regulation of receptor-mediated endocytosis)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0120146"(sulfatide binding)|interpro:IPR002472(Palmitoyl protein thioesterase)|interpro:IPR029058|interpro:IPR030294|reactome:R-MMU-75105|go:"GO:0032429"(regulation of phospholipase A2 activity)	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:15073(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4dRWzI9cOsETRgn1q2atEkD3Ok410090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:F0E741BC183A4381|rigid:mR9H3qeryx2eUWr5fMWU1Rhex28	false	sufficient binding region:?-?	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80UY2	uniprotkb:P35991	intact:EBI-642649|uniprotkb:Q9WUM2|ensembl:ENSMUSP00000064410	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:kcmf1_mouse(display_long)|uniprotkb:Debt91(gene name synonym)|uniprotkb:Differentially expressed in branching tubulogenesis 91(gene name synonym)|uniprotkb:Kcmf1(gene name)|psi-mi:Kcmf1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase KCMF1(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650054	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062689.2|ensembl:ENSMUSG00000055239(gene)|ensembl:ENSMUST00000068697(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0045202"(synapse)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0099536"(synaptic signaling)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR008598(Drought induced 19)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR039858|interpro:IPR043145|reactome:R-MMU-6798695	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:18234(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:xlwfDbJjXyoCY6iMHVcGOLDqjHc10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:67EFF818B4A23EE0|rigid:zUn+ifxxgP8x0/1aSLHHpOPIJCw	false	sufficient binding region:95-268	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WVM3	uniprotkb:P42337	intact:EBI-642653|uniprotkb:Q3UBM7|uniprotkb:Q8BSR2|uniprotkb:Q91W13|ensembl:ENSMUSP00000031422|ensembl:ENSMUSP00000113928	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:apc7_mouse(display_long)|uniprotkb:Cyclosome subunit 7(gene name synonym)|uniprotkb:Prediabetic NOD sera-reactive autoantigen(gene name synonym)|uniprotkb:Apc7(gene name synonym)|uniprotkb:Anapc7(gene name)|psi-mi:Anapc7(display_short)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650064	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062779.3|ensembl:ENSMUSG00000029466(gene)|ensembl:ENSMUST00000031422(transcript)|ensembl:ENSMUST00000122010(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005680"(anaphase-promoting complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0007091"(metaphase/anaphase transition of mitotic cell cycle)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0031145"(anaphase-promoting complex-dependent catabolic process)|go:"GO:0045842"(positive regulation of mitotic metaphase/anaphase transition)|go:"GO:0051301"(cell division)|go:"GO:0070979"(protein K11-linked ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|reactome:R-MMU-141430|reactome:R-MMU-174048|reactome:R-MMU-174084|reactome:R-MMU-174154|reactome:R-MMU-174178|reactome:R-MMU-174184|reactome:R-MMU-176407|reactome:R-MMU-176408|reactome:R-MMU-176409|reactome:R-MMU-176412|reactome:R-MMU-179409|reactome:R-MMU-2467813|reactome:R-MMU-2559582|reactome:R-MMU-69017|reactome:R-MMU-983168|go:"GO:0005819"(spindle)	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	afcs:15011(primary-reference)|afcs:18315(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:kGGF+W/eposBQfb3C/PiDJEdC+k10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:8EB35754433742F3|rigid:ZRrLSNCjAmu2xidXli4Bx9CtUKY	false	sufficient binding region:265-534	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3UND0	uniprotkb:Q9JL25	intact:EBI-642769|uniprotkb:Q8BK74|uniprotkb:Q9Z2K4|ensembl:ENSMUSP00000145462	intact:EBI-642400|uniprotkb:Q3TBD1|uniprotkb:Q3TC18|uniprotkb:Q3TD56|uniprotkb:Q3U477|ensembl:ENSMUSP00000140624	psi-mi:skap2_mouse(display_long)|uniprotkb:Src family-associated phosphoprotein 2(gene name synonym)|uniprotkb:Src kinase-associated phosphoprotein 55-related protein(gene name synonym)|uniprotkb:SKAP55 homolog(gene name synonym)|uniprotkb:Src-associated adapter protein with PH and SH3 domains(gene name synonym)|uniprotkb:Pyk2/RAFTK-associated protein(gene name synonym)|uniprotkb:Skap2(gene name)|psi-mi:Skap2(display_short)|uniprotkb:Prap(gene name synonym)|uniprotkb:Saps(gene name synonym)|uniprotkb:Ra70(gene name synonym)|uniprotkb:Scap2(gene name synonym)|uniprotkb:Skap55r(gene name synonym)	psi-mi:rgs1_mouse(display_long)|uniprotkb:Rgs1(gene name)|psi-mi:Rgs1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650155	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061243.1|ensembl:ENSMUSG00000059182(gene)|ensembl:ENSMUST00000204778(transcript)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0042113"(B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR036028|interpro:IPR037781|rcsb pdb:1M0V|rcsb pdb:1U5E|rcsb pdb:1U5F|rcsb pdb:1U5G|rcsb pdb:2OTX|reactome:R-MMU-391160	refseq:NP_056626.2|reactome:R-MMU-416476|reactome:R-MMU-418594|interpro:IPR036305|ensembl:ENSMUSG00000026358(gene)|ensembl:ENSMUST00000189061(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0061737"(leukotriene signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR030409	afcs:17628(primary-reference)|afcs:17939(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2WPz/JocPjHR9w8dHv5ha396QWQ10090	rogid:tkOVK7JJ2n/5EyhCM6ChMjMWv6410090	intact-crc:7362E6FC600020C6|rigid:6C+1b0ctPZTzeMuBQXk73sZGFzc	false	sufficient binding region:130-358	sufficient binding region:14-113	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01320	uniprotkb:Q8BWG8	intact:EBI-642809|uniprotkb:E9PX08|ensembl:ENSMUSP00000068896	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:top2a_mouse(display_long)|uniprotkb:DNA topoisomerase II, alpha isozyme(gene name synonym)|uniprotkb:Top2a(gene name)|psi-mi:Top2a(display_short)|uniprotkb:Top2(gene name synonym)|uniprotkb:Top-2(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650235	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006533216.1|refseq:NP_035753.2|interpro:IPR031660|interpro:IPR034157|interpro:IPR036890|mint:Q01320|reactome:R-MMU-4615885|interpro:IPR020568|ensembl:ENSMUSG00000020914(gene)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0000712"(resolution of meiotic recombination intermediates)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000819"(sister chromatid segregation)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003916"(DNA topoisomerase activity)|go:"GO:0003918"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity")|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005814"(centriole)|go:"GO:0006265"(DNA topological change)|go:"GO:0006266"(DNA ligation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008094"(ATP-dependent activity, acting on DNA)|go:"GO:0008301"(DNA binding, bending)|go:"GO:0009330"("DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex")|go:"GO:0019899"(enzyme binding)|go:"GO:0030261"(chromosome condensation)|ensembl:ENSMUST00000068031(transcript)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0042752"(regulation of circadian rhythm)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045870"(positive regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048511"(rhythmic process)|go:"GO:0051309"(female meiosis chromosome separation)|go:"GO:1905463"(negative regulation of DNA duplex unwinding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR001241(DNA topoisomerase, type IIA, subunit B or N-terminal)|interpro:IPR002205(DNA topoisomerase, type IIA, subunit A or C-terminal)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR006171(TOPRIM)|interpro:IPR012542(DTHCT)|interpro:IPR013506(DNA topoisomerase, type IIA, subunit B, region 2)|interpro:IPR013757(DNA topoisomerase, type IIA, subunit A, alpha-helical)|interpro:IPR013758(DNA topoisomerase, type IIA, subunit A or C-terminal, alpha-beta)|interpro:IPR013759(DNA topoisomerase, type IIA, subunit B or N-terminal, alpha-beta)|interpro:IPR013760(DNA topoisomerase, type IIA, central)|interpro:IPR014721(Ribosomal protein S5 domain 2-type fold)|interpro:IPR018522|go:"GO:0030263"(apoptotic chromosome condensation)|dip:DIP-40621N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:16882(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4bT7YxXbxkbqULDvXoFRreoX9Gs10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:468A2E4F561BC74A|rigid:bnAwiRe056D9U+2763ETmV0SoY0	false	sufficient binding region:506-675	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49312	uniprotkb:Q8BWG8	intact:EBI-642826|uniprotkb:P97312|uniprotkb:Q3V269|ensembl:ENSMUSP00000084609|ensembl:ENSMUSP00000155833	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:roa1_mouse(display_long)|uniprotkb:Hnrpa1(gene name synonym)|uniprotkb:hnRNP core protein A1(gene name synonym)|uniprotkb:Helix-destabilizing protein(gene name synonym)|uniprotkb:HDP-1(gene name synonym)|uniprotkb:Single-strand-binding protein(gene name synonym)|uniprotkb:Topoisomerase-inhibitor suppressed(gene name synonym)|uniprotkb:Hnrnpa1(gene name)|psi-mi:Hnrnpa1(display_short)|uniprotkb:Fli-2(gene name synonym)|uniprotkb:Tis(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650245	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034577.1|ensembl:ENSMUSG00000046434(gene)|ensembl:ENSMUST00000087351(transcript)|ensembl:ENSMUST00000230171(transcript)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0035198"(miRNA binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051168"(nuclear export)|go:"GO:0051170"(import into nucleus)|go:"GO:1903936"(cellular response to sodium arsenite)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021662|interpro:IPR034803|interpro:IPR034845|interpro:IPR035979|mint:P49312|go:"GO:0008380"(RNA splicing)|reactome:R-MMU-6803529|reactome:R-MMU-72163|reactome:R-MMU-72203	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:12980(secondary-ac)	-	-	caution:The prey construct contains 3 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Co5hW3ZlIoa2k56GA2/9RJBNguI10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:27C4AF0A75500C35|rigid:IrEVS4WLkBlk6RofJEP9WL9O2qQ	false	sufficient binding region:2-186	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62219	uniprotkb:Q99N72	intact:EBI-642844|ensembl:ENSMUSP00000132100|uniprotkb:Q3YBY7|uniprotkb:Q3YBY8|uniprotkb:Q3YBZ0|uniprotkb:Q3YBZ1|uniprotkb:Q3YBZ3|uniprotkb:Q3YBZ4|uniprotkb:Q3YBZ5|uniprotkb:Q3YBZ6	intact:EBI-641874	psi-mi:tgfi1_mouse(display_long)|uniprotkb:Tgfb1i1(gene name)|psi-mi:Tgfb1i1(display_short)|uniprotkb:Ara55(gene name synonym)|uniprotkb:Hydrogen peroxide-inducible clone 5 protein(gene name synonym)|uniprotkb:Androgen receptor-associated protein of 55 kDa(gene name synonym)|uniprotkb:TGF beta-stimulated clone 5(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650255	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000030782(gene)|ensembl:ENSMUST00000167965(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0009408"(response to heat)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0030855"(epithelial cell differentiation)|go:"GO:0045165"(cell fate commitment)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|refseq:NP_001276479.1|refseq:NP_001276481.1|refseq:NP_001276482.1|refseq:XP_006507630.1|go:"GO:0050681"(androgen receptor binding)|go:"GO:0070411"(I-SMAD binding)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR017305(Leupaxin)|mint:Q62219|go:"GO:0048495"(Roundabout binding)	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:15441(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bh/xIQopXbPvHwdsY0wpv6OehT810090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:3B36117A59BF1D69|rigid:ZfyXiSGnZgsh4yr2eqoBeGMVCzk	false	sufficient binding region:72-444	sufficient binding region:325-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P68369	uniprotkb:P35991	intact:EBI-400542|uniprotkb:P02551|uniprotkb:P05210|uniprotkb:P05212|uniprotkb:Q3TGF0|uniprotkb:Q3TIW2|uniprotkb:Q3TPJ1|uniprotkb:Q3ULN1|uniprotkb:Q5XJF8|ensembl:ENSMUSP00000094778	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:tba1a_mouse(display_long)|uniprotkb:Tuba1a(gene name)|psi-mi:Tuba1a(display_short)|uniprotkb:Tubulin alpha-1 chain(gene name synonym)|uniprotkb:Alpha-tubulin 1(gene name synonym)|uniprotkb:Alpha-tubulin isotype M-alpha-1(gene name synonym)|uniprotkb:Tuba1(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650265	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035783.1|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-437239|reactome:R-MMU-5610787|reactome:R-MMU-5617833|reactome:R-MMU-5620912|reactome:R-MMU-5620924|reactome:R-MMU-5626467|reactome:R-MMU-5663220|reactome:R-MMU-6807878|reactome:R-MMU-6811434|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8852276|reactome:R-MMU-8854518|reactome:R-MMU-8955332|reactome:R-MMU-9646399|reactome:R-MMU-9648025|reactome:R-MMU-9668328|reactome:R-MMU-983189|ensembl:ENSMUSG00000072235(gene)|ensembl:ENSMUST00000097014(transcript)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0045121"(membrane raft)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0055037"(recycling endosome)|interpro:IPR000217(Tubulin)|interpro:IPR002452(Alpha tubulin)|interpro:IPR003008(Tubulin/FtsZ, GTPase)|interpro:IPR008280(Tubulin/FtsZ, C-terminal)|interpro:IPR017975|interpro:IPR018316|interpro:IPR023123|interpro:IPR036525|interpro:IPR037103|mint:P68369|rcsb pdb:6JZD|reactome:R-MMU-190840|reactome:R-MMU-2132295	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:16899(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1CzEzrf5y8hrQRPKgWQS1Wm1aCY10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:81C3E7DEF3B0C0D0|rigid:/yQGKcQRzfFT6C299wOEbFw3T8M	false	sufficient binding region:184-451	sufficient binding region:210-280	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ES28	uniprotkb:Q9JLQ2	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	intact:EBI-642860|uniprotkb:E9QPU7|ensembl:ENSMUSP00000107803	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:git2_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 2(gene name synonym)|uniprotkb:GRK-interacting protein 2(gene name synonym)|uniprotkb:Cool-interacting tyrosine-phosphorylated protein 2(gene name synonym)|uniprotkb:Git2(gene name)|psi-mi:Git2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650307	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	refseq:NP_062808.3|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q9JLQ2|rcsb pdb:6JMT|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|ensembl:ENSMUSG00000041890(gene)|ensembl:ENSMUST00000112185(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)	afcs:17882(primary-reference)|afcs:18337(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	rogid:mOkKto/u8bzW0feEp3Kah7fYeOI10090	intact-crc:D26027FC5902DE4A|rigid:Gf/L0bks/IehTveMU+ldy5LxVDw	false	sufficient binding region:300-581	sufficient binding region:133-397	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P20152	uniprotkb:Q8BWG8	intact:EBI-299269|ensembl:ENSMUSP00000028062|uniprotkb:O08704|uniprotkb:Q8CCH1	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:vime_mouse(display_long)|uniprotkb:Vim(gene name)|psi-mi:Vim(display_short)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650337	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000026728(gene)|ensembl:ENSMUST00000028062(transcript)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005737"(cytoplasm)|go:"GO:0005777"(peroxisome)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005882"(intermediate filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0014002"(astrocyte development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0045109"(intermediate filament organization)|go:"GO:0045111"(intermediate filament cytoskeleton)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060395"(SMAD protein signal transduction)|go:"GO:0070307"(lens fiber cell development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071225"(cellular response to muramyl dipeptide)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0097110"(scaffold protein binding)|go:"GO:1900147"(regulation of Schwann cell migration)|go:"GO:1990254"(keratin filament binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR006821(Intermediate filament, DNA-binding region)|interpro:IPR018039|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0031252"(cell leading edge)|interpro:IPR027699|interpro:IPR039008|mint:P20152|reactome:R-MMU-264870|reactome:R-MMU-390522|reactome:R-MMU-9013422|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|reactome:R-MMU-9646399|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044297"(cell body)|go:"GO:0045098"(type III intermediate filament)|go:"GO:0045103"(intermediate filament-based process)|refseq:NP_035831.2|dip:DIP-188N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:6786(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid://GDvGAXOR4hUXNtVpnZefex5v410090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:85FF66F8B6CB34C8|rigid:LTBWIwn0MWk3UoE1R1blyryJV/Q	false	sufficient binding region:151-466	sufficient binding region:150-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28301	uniprotkb:P35991	intact:EBI-642911|ensembl:ENSMUSP00000025409|ensembl:ENSMUSP00000129247	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:lyox_mouse(display_long)|uniprotkb:Lysyl oxidase(gene name synonym)|uniprotkb:Ras excision protein(gene name synonym)|uniprotkb:Lox(gene name)|psi-mi:Lox(display_short)|uniprotkb:Rrg(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650419	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273110.1|refseq:NP_001273111.1|refseq:NP_034858.2|ensembl:ENSMUSG00000024529(gene)|ensembl:ENSMUST00000025409(transcript)|ensembl:ENSMUST00000171470(transcript)|go:"GO:0031012"(extracellular matrix)|go:"GO:0035791"(platelet-derived growth factor receptor-beta signaling pathway)|go:"GO:0035904"(aorta development)|go:"GO:0035905"(ascending aorta development)|go:"GO:0035906"(descending aorta development)|go:"GO:0042060"(wound healing)|go:"GO:0001568"(blood vessel development)|go:"GO:0042493"|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045652"(regulation of megakaryocyte differentiation)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048251"(elastic fiber assembly)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0048545"(response to steroid hormone)|go:"GO:0055001"(muscle cell development)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0061448"(connective tissue development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071897"(DNA biosynthetic process)|go:"GO:1900120"(regulation of receptor binding)|go:"GO:1903010"(regulation of bone development)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000586"(regulation of platelet-derived growth factor receptor-beta signaling pathway)|interpro:IPR001695(Lysyl oxidase)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0004720"(protein-lysine 6-oxidase activity)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0005507"(copper ion binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005581"(collagen trimer)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0007507"(heart development)|go:"GO:0009725"(response to hormone)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0017015"(regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0018057"(peptidyl-lysine oxidation)|go:"GO:0018158"(protein oxidation)|go:"GO:0030199"(collagen fibril organization)|go:"GO:0030282"(bone mineralization)|go:"GO:0030324"(lung development)|interpro:IPR019828|mint:P28301|reactome:R-MMU-1566948|reactome:R-MMU-2243919	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:16337(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ehv+lVMTVIzWWWxaRlO+aIY53jk10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:B3A69685E1833FAE|rigid:cIThKH3tE4dpVDMVGIfYVXmmtIg	false	sufficient binding region:27-176	sufficient binding region:210-280	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62419	uniprotkb:Q9QUN3	intact:EBI-642935|ensembl:ENSMUSP00000003268	intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844	psi-mi:sh3g1_mouse(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3p8(gene name synonym)|uniprotkb:Sh3gl1(gene name)|psi-mi:Sh3gl1(display_short)|uniprotkb:Sh3d2b(gene name synonym)	psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650449	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038692.1|ensembl:ENSMUSG00000003200(gene)|ensembl:ENSMUST00000003268(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q62419|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0099092"(postsynaptic density, intracellular component)	refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)	afcs:21969(primary-reference)|afcs:7176(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:IJQKTkGQglD3qko38oEulqRvyrQ10090	rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090	intact-crc:F715AE86F30D9600|rigid:P4PfWzBrmHaSh25SWPY0gyZqIh0	false	sufficient binding region:152-368	sufficient binding region:1-241	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62018	uniprotkb:Q04683	intact:EBI-644452|uniprotkb:Q3UFF5|uniprotkb:Q3UY40|uniprotkb:Q66JX4|uniprotkb:Q7TPS6|uniprotkb:Q8BND9|uniprotkb:Q8BRD1|uniprotkb:Q8C9W7|uniprotkb:Q8C9Y3|uniprotkb:Q8CHI1|ensembl:ENSMUSP00000005749	intact:EBI-644441|uniprotkb:Q6P3C2|ensembl:ENSMUSP00000050444|ensembl:ENSMUSP00000137518|ensembl:ENSMUSP00000149508	psi-mi:ctr9_mouse(display_long)|uniprotkb:SH2 domain-binding protein 1(gene name synonym)|uniprotkb:Tetratricopeptide repeat-containing, SH2-binding phosphoprotein of 150 kDa(gene name synonym)|uniprotkb:Ctr9(gene name)|psi-mi:Ctr9(display_short)|uniprotkb:Kiaa0155(gene name synonym)|uniprotkb:Sh2bp1(gene name synonym)	psi-mi:cxcr5_mouse(display_long)|uniprotkb:Burkitt lymphoma receptor 1 homolog(gene name synonym)|uniprotkb:Cxcr5(gene name)|psi-mi:Cxcr5(display_short)|uniprotkb:Blr1(gene name synonym)|uniprotkb:Gpcr6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652331	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033457.2|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006368"(transcription elongation from RNA polymerase II promoter)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0010390"(histone monoubiquitination)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016593"(Cdc73/Paf1 complex)|go:"GO:0016607"(nuclear speck)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0033523"(histone H2B ubiquitination)|go:"GO:0035327"|go:"GO:0042169"(SH2 domain binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0051569"(regulation of histone H3-K4 methylation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0080182"(histone H3-K4 trimethylation)|go:"GO:1900364"(negative regulation of mRNA polyadenylation)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2001162"(positive regulation of histone H3-K79 methylation)|go:"GO:2001168"(positive regulation of histone H2B ubiquitination)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031101|mint:Q62018|reactome:R-MMU-112382|reactome:R-MMU-674695|reactome:R-MMU-75955|reactome:R-MMU-8866654|go:"GO:0071222"(cellular response to lipopolysaccharide)|ensembl:ENSMUSG00000005609(gene)|ensembl:ENSMUST00000005749(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000993"(RNA polymerase II complex binding)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001826"(inner cell mass cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001832"(blastocyst growth)|go:"GO:0001835"(blastocyst hatching)	refseq:NP_031577.2|go:"GO:0042113"(B cell activation)|go:"GO:0048535"(lymph node development)|go:"GO:0060326"(cell chemotaxis)|interpro:IPR000276(GPCR, rhodopsin-like)|interpro:IPR001053(C-X-C chemokine receptor, type 5)|interpro:IPR017452(GPCR, rhodopsin-like superfamily)|reactome:R-MMU-380108|reactome:R-MMU-418594|go:"GO:0032467"(positive regulation of cytokinesis)|ensembl:ENSMUSG00000047880(gene)|ensembl:ENSMUST00000062215(transcript)|ensembl:ENSMUST00000179828(transcript)|ensembl:ENSMUST00000215293(transcript)|go:"GO:0006955"(immune response)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016493"(C-C chemokine receptor activity)|go:"GO:0016494"(C-X-C chemokine receptor activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0030595"(leukocyte chemotaxis)	afcs:13931(primary-reference)|afcs:15497(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:D1n7ZSSSZL7dLYvcuEkIkttdmg810090	rogid:EQxUxBOdGtZomn1dfWOgYXte97810090	intact-crc:605A2547CB8F7446|rigid:X8/oFEjVGRAkDCnAnvllNWjip5c	false	sufficient binding region:313-516	sufficient binding region:315-374	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P04627	uniprotkb:P32883-2	intact:EBI-644485|uniprotkb:Q99J44|uniprotkb:Q9CTT5|uniprotkb:Q9D6R6|uniprotkb:Q9DBU7|uniprotkb:B1AUN9|ensembl:ENSMUSP00000001155	intact:EBI-644285|uniprotkb:P08643-1|ensembl:ENSMUSP00000032399	psi-mi:araf_mouse(display_long)|uniprotkb:Araf(gene name)|psi-mi:Araf(display_short)|uniprotkb:A-raf(gene name synonym)|uniprotkb:Araf1(gene name synonym)|uniprotkb:Proto-oncogene A-Raf(gene name synonym)	psi-mi:p32883-2(display_long)|uniprotkb:Kras(gene name)|psi-mi:Kras(display_short)|uniprotkb:Kras2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652435	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001153117.1|refseq:NP_033833.1|ensembl:ENSMUSG00000001127(gene)|ensembl:ENSMUST00000001155(transcript)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0032006"(regulation of TOR signaling)|go:"GO:0032434"(regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|mint:P04627|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5675221|refseq:XP_006527619.1|refseq:XP_006527620.1|dip:DIP-1070N	intact:EBI-644267(rask_mouse)|ensembl:ENSMUSG00000030265(gene)|ensembl:ENSMUST00000032399(transcript)	afcs:34274(primary-reference)|afcs:39332(secondary-ac)	-	-	caution:The prey construct contains 5 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/0GyghXkkvb5pkn538YAgEqPepI10090	rogid:QQ2jCFyfJfOiwuQ4vrh9ZZ0C0y810090	intact-crc:B856BBBBFA07BC6A|rigid:uGJGB0aJk+wC+ztmWlk5SAq8ojE	false	sufficient binding region:1-205	sufficient binding region:1-188	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIF7	uniprotkb:E9Q401	intact:EBI-643655|uniprotkb:Q3T9Y4|uniprotkb:Q3TT72|uniprotkb:Q3U8G9|uniprotkb:Q3UE02|ensembl:ENSMUSP00000033012	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	psi-mi:copb_mouse(display_long)|uniprotkb:Beta-coat protein(gene name synonym)|uniprotkb:Copb1(gene name)|psi-mi:Copb1(display_short)|uniprotkb:Copb(gene name synonym)	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651330	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_203534.1|ensembl:ENSMUSG00000030754(gene)|ensembl:ENSMUST00000033012(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:Q9JIF7|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811434|dip:DIP-42642N	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	afcs:24653(primary-reference)|afcs:30821(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:iDZBrOVDDEDKOg968HyvA3hXWF810090	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	intact-crc:379AD8C3E86D100E|rigid:Bw0EbSBQaOCABr16VLMW2flnNlc	false	sufficient binding region:644-953	sufficient binding region:625-901	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88597	uniprotkb:O08908	intact:EBI-643716|uniprotkb:Q99J03|ensembl:ENSMUSP00000119369	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:becn1_mouse(display_long)|uniprotkb:Coiled-coil myosin-like BCL2-interacting protein(gene name synonym)|uniprotkb:Becn1(gene name)|psi-mi:Becn1(display_short)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651393	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062530.2|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010508"(positive regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0016020"(membrane)|go:"GO:0016236"(macroautophagy)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032801"(receptor catabolic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033197"(response to vitamin E)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034271"(phosphatidylinositol 3-kinase complex, class III, type I)|go:"GO:0034272"(phosphatidylinositol 3-kinase complex, class III, type II)|go:"GO:0035032"(phosphatidylinositol 3-kinase complex, class III)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048666"(neuron development)|go:"GO:0050435"(amyloid-beta metabolic process)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051020"(GTPase binding)|go:"GO:0051301"(cell division)|go:"GO:0051607"(defense response to virus)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0071275"(cellular response to aluminum ion)|go:"GO:0071280"(cellular response to copper ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1902425"(positive regulation of attachment of mitotic spindle microtubules to kinetochore)|go:"GO:1902902"(negative regulation of autophagosome assembly)|go:"GO:1905672"(negative regulation of lysosome organization)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR007243(Autophagy protein 6)|interpro:IPR029318|interpro:IPR032913|interpro:IPR038274|interpro:IPR040455|interpro:IPR041691|mint:O88597|rcsb pdb:3BL2|rcsb pdb:5YR0|reactome:R-MMU-1632852|reactome:R-MMU-5689880|go:"GO:0010288"(response to lead ion)|ensembl:ENSMUSG00000035086(gene)|ensembl:ENSMUST00000130916(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000422"(autophagy of mitochondrion)|go:"GO:0000423"(mitophagy)|go:"GO:0001525"(angiogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0006995"(cellular response to nitrogen starvation)|go:"GO:0007040"(lysosome organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0007568"(aging)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010040"("response to iron(II) ion")|dip:DIP-41636N	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:9123(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uQ3D8xs/5TTtmm08qbcSmU7CmiE10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:97B8150050D77F86|rigid:d0vYyWZYE4/WAKNavbM1Xt1bIuw	false	sufficient binding region:113-364	sufficient binding region:497-722	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62419	uniprotkb:O08908	intact:EBI-642935|ensembl:ENSMUSP00000003268	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:sh3g1_mouse(display_long)|uniprotkb:Endophilin-2(gene name synonym)|uniprotkb:SH3 domain-containing GRB2-like protein 1(gene name synonym)|uniprotkb:SH3 domain protein 2B(gene name synonym)|uniprotkb:SH3p8(gene name synonym)|uniprotkb:Sh3gl1(gene name)|psi-mi:Sh3gl1(display_short)|uniprotkb:Sh3d2b(gene name synonym)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651403	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038692.1|ensembl:ENSMUSG00000003200(gene)|ensembl:ENSMUST00000003268(transcript)|go:"GO:0002102"(podosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016020"(membrane)|go:"GO:0016191"(synaptic vesicle uncoating)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0031697"(beta-1 adrenergic receptor binding)|go:"GO:0031901"(early endosome membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045202"(synapse)|go:"GO:0051020"(GTPase binding)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098815"(modulation of excitatory postsynaptic potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:1900244"(positive regulation of synaptic vesicle endocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR004148(BAR)|interpro:IPR027267|interpro:IPR028501|interpro:IPR035824|interpro:IPR036028|mint:Q62419|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|go:"GO:0099092"(postsynaptic density, intracellular component)	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:7176(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:IJQKTkGQglD3qko38oEulqRvyrQ10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:71B0246045C8F3A8|rigid:owcEy56m/3g4bmuVGKRyZmGYhLY	false	sufficient binding region:242-368	sufficient binding region:497-722	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1S8	uniprotkb:Q60631	intact:EBI-641738|uniprotkb:Q9R1X3	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648501	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:16043(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:B2E33443C2FBD576|rigid:jxUcaDe25ZuQ9CPbYDfeVHR1i24	false	sufficient binding region:276-522	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P39054-2	uniprotkb:Q60631	intact:EBI-642353|ensembl:ENSMUSP00000088616	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:p39054-2(display_long)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym)|uniprotkb:Dynamin UDNM(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653071	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-642337(dyn2_mouse)|ensembl:ENSMUSG00000033335(gene)|ensembl:ENSMUST00000091087(transcript)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:14203(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:erJ4QqPwOjhyjX7e5ST4NEus3lo10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:242F6F6BDA530007|rigid:Ps7eolqrNDGAgkHjQDdlqCfN1KE	false	sufficient binding region:638-812	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JLQ0	uniprotkb:Q60631	intact:EBI-644807|uniprotkb:E9QL86|uniprotkb:O88903|uniprotkb:Q8K4Z1|uniprotkb:Q8VCI9|ensembl:ENSMUSP00000024709	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:cd2ap_mouse(display_long)|uniprotkb:Mesenchyme-to-epithelium transition protein with SH3 domains 1(gene name synonym)|uniprotkb:Cd2ap(gene name)|psi-mi:Cd2ap(display_short)|uniprotkb:Mets1(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653081	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033977.3|ensembl:ENSMUSG00000061665(gene)|ensembl:ENSMUST00000024709(transcript)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0005172"(vascular endothelial growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0007049"(cell cycle)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0016050"(vesicle organization)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0031941"(filamentous actin)|go:"GO:0031982"(vesicle)|go:"GO:0032911"(negative regulation of transforming growth factor beta1 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0048259"(regulation of receptor-mediated endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0051058"(negative regulation of small GTPase mediated signal transduction)|go:"GO:0051301"(cell division)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR028445|interpro:IPR035775|interpro:IPR035776|interpro:IPR035777|interpro:IPR036028|mint:Q9JLQ0|rcsb pdb:2JTE|rcsb pdb:2KRM|rcsb pdb:2KRN|rcsb pdb:2KRO|rcsb pdb:2LZ6|rcsb pdb:2MCN|go:"GO:1900182"(positive regulation of protein localization to nucleus)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:11976(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:siNa7wmze02HJhbUEEGxQaczJCQ10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:FB9DCF1508BA800B|rigid:gDnRxHoRMn6Sj+3nDN4Y6SY00/M	false	sufficient binding region:266-637	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYY0	uniprotkb:Q60631	intact:EBI-644784|uniprotkb:Q91VW7|ensembl:ENSMUSP00000034150	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:gab1_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:Gab1(gene name)|psi-mi:Gab1(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653101	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067331.2|ensembl:ENSMUSG00000031714(gene)|ensembl:ENSMUST00000034150(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q9QYY0|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-180292|reactome:R-MMU-1963642|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027276|dip:DIP-39377N	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:23867(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SVtcnzm9XpYftTZ3qAV/IQgJaJE10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:CF2D52F8115A8A65|rigid:13M3xZwRnCfCOmPvxLBYhBXNEZw	false	sufficient binding region:42-589	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYY0	uniprotkb:Q60631	intact:EBI-644784|uniprotkb:Q91VW7|ensembl:ENSMUSP00000034150	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:gab1_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:Gab1(gene name)|psi-mi:Gab1(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653111	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067331.2|ensembl:ENSMUSG00000031714(gene)|ensembl:ENSMUST00000034150(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q9QYY0|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-180292|reactome:R-MMU-1963642|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027276|dip:DIP-39377N	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:23867(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SVtcnzm9XpYftTZ3qAV/IQgJaJE10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:6093C372E6FB44B3|rigid:13M3xZwRnCfCOmPvxLBYhBXNEZw	false	sufficient binding region:67-591	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYY0	uniprotkb:Q60631	intact:EBI-644784|uniprotkb:Q91VW7|ensembl:ENSMUSP00000034150	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:gab1_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:Gab1(gene name)|psi-mi:Gab1(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653121	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067331.2|ensembl:ENSMUSG00000031714(gene)|ensembl:ENSMUST00000034150(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q9QYY0|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-180292|reactome:R-MMU-1963642|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027276|dip:DIP-39377N	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:23867(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SVtcnzm9XpYftTZ3qAV/IQgJaJE10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:6679AB35E180621D|rigid:13M3xZwRnCfCOmPvxLBYhBXNEZw	false	sufficient binding region:85-623	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYY0	uniprotkb:Q60631	intact:EBI-644784|uniprotkb:Q91VW7|ensembl:ENSMUSP00000034150	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:gab1_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:Gab1(gene name)|psi-mi:Gab1(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653131	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067331.2|ensembl:ENSMUSG00000031714(gene)|ensembl:ENSMUST00000034150(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q9QYY0|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-180292|reactome:R-MMU-1963642|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027276|dip:DIP-39377N	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:23867(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SVtcnzm9XpYftTZ3qAV/IQgJaJE10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:645D9E9BCEBC29E3|rigid:13M3xZwRnCfCOmPvxLBYhBXNEZw	false	sufficient binding region:286-569	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60631	uniprotkb:Q60992	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	intact:EBI-643726|uniprotkb:A2AH49|ensembl:ENSMUSP00000062782	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:vav2_mouse(display_long)|uniprotkb:Vav2(gene name)|psi-mi:Vav2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653141	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	refseq:NP_033526.1|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:Q60992|reactome:R-MMU-114604|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-3928665|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-445144|reactome:R-MMU-5218920|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|interpro:IPR000980(SH2 motif)|ensembl:ENSMUSG00000009621(gene)|ensembl:ENSMUST00000056176(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")	afcs:15546(primary-reference)|afcs:53767(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rogid:PYI5dXgxDpwXCc7HMwQFN4H15Zs10090	intact-crc:F3445A2951EF61E6|rigid:B0B9ng24tiuty7s+EYCorRXpTIQ	false	sufficient binding region:23-217	sufficient binding region:560-868	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99JZ7	uniprotkb:Q60631	intact:EBI-643375|ensembl:ENSMUSP00000073285|ensembl:ENSMUSP00000030811	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:errfi_mouse(display_long)|uniprotkb:Mitogen-inducible gene 6 protein homolog(gene name synonym)|uniprotkb:Errfi1(gene name)|psi-mi:Errfi1(display_short)|uniprotkb:Mig6(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653172	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598514.1|refseq:XP_006539273.1|ensembl:ENSMUSG00000028967(gene)|ensembl:ENSMUST00000030811(transcript)|ensembl:ENSMUST00000073600(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060426"(lung vasculature development)|go:"GO:0060428"(lung epithelium development)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR015116(GTPase binding)|interpro:IPR021619	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:34646(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:flZOynxPIeNiLKGeuDeo6JXWdgw10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:7E99998F417DBD7C|rigid:2cUgsEZtkBivgkb1Rz95wOQcBKY	false	sufficient binding region:179-418	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26450	uniprotkb:Q8BTI9	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653192	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	afcs:33521(primary-reference)|afcs:52679(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:B8123CE3B64ADAC3|rigid:PAfHn4I8b9i0RMOF+ngaysjOeLI	false	sufficient binding region:58-577	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26450	uniprotkb:Q8BTI9	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653202	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	afcs:33521(primary-reference)|afcs:52679(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:FB66C5837910A3A8|rigid:PAfHn4I8b9i0RMOF+ngaysjOeLI	false	sufficient binding region:405-593	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26450	uniprotkb:Q8BTI9	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653212	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	afcs:33521(primary-reference)|afcs:52679(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:18B6009B336027DC|rigid:PAfHn4I8b9i0RMOF+ngaysjOeLI	false	sufficient binding region:442-633	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26450	uniprotkb:Q8BTI9	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653222	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	afcs:33521(primary-reference)|afcs:52679(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:EAD47730E84E369F|rigid:PAfHn4I8b9i0RMOF+ngaysjOeLI	false	sufficient binding region:469-576	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64143	uniprotkb:Q8BTI9	intact:EBI-642901|ensembl:ENSMUSP00000030464	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:p55g_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma(gene name synonym)|uniprotkb:p55PIK(gene name synonym)|uniprotkb:Pik3r3(gene name)|psi-mi:Pik3r3(display_short)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653252	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_853616.1|interpro:IPR035022|interpro:IPR036860|reactome:R-MMU-114604|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-912526|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-912631|interpro:IPR032498|interpro:IPR035020|ensembl:ENSMUSG00000028698(gene)|ensembl:ENSMUST00000030464(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0043491"(protein kinase B signaling)|refseq:XP_017175528.1|refseq:XP_017175529.1	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	afcs:33521(primary-reference)|afcs:52685(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1xjaa7ceA151Mo51DvSlCFeTTFY10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:A5C57D01F8C0492A|rigid:N7KGnOtKNd1LhnoZ0Rcc55g49MI	false	sufficient binding region:83-346	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:Q60631	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653262	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:9E38AE2CAB0C5A88|rigid:SJLmhyEsa7AJ3Dhmz77Bj+dv3DA	false	sufficient binding region:22-367	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60631	uniprotkb:B9EKI5	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	intact:EBI-682463|ensembl:ENSMUSP00000110115|ensembl:ENSMUSP00000154583	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:b9eki5_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688336	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	refseq:NP_001028410.1|refseq:XP_006522014.1|ensembl:ENSMUSG00000022637(gene)|ensembl:ENSMUST00000114471(transcript)|ensembl:ENSMUST00000227062(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023051"(regulation of signaling)|go:"GO:0047690"(aspartyltransferase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520	afcs:20358(secondary-ac)|afcs:53767(primary-reference)|afcs:20358(primary-reference)	-	comment:"AfCS Y2H protein 20358. Sequence deduced from cross-reference: protein GI: 20894431, replaced by protein GI: 51769670."|comment:"similat to rat Casitas B-lineage lymphoma b; Cbl-b protein (98%)"	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	rogid:/a/ZrHmGa1+dJMyubsxdzGfCrdQ10090	intact-crc:BBF5E6DA6F9F1038|rigid:ZKP7/Askv0dep7OrB42aPBnZBXI	false	sufficient binding region:1-217	sufficient binding region:319-486	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99N57	uniprotkb:P32883-2	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	intact:EBI-644285|uniprotkb:P08643-1|ensembl:ENSMUSP00000032399	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:p32883-2(display_long)|uniprotkb:Kras(gene name)|psi-mi:Kras(display_short)|uniprotkb:Kras2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652301	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	intact:EBI-644267(rask_mouse)|ensembl:ENSMUSG00000030265(gene)|ensembl:ENSMUST00000032399(transcript)	afcs:34274(primary-reference)|afcs:6639(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rogid:QQ2jCFyfJfOiwuQ4vrh9ZZ0C0y810090	intact-crc:D930FDF27DC023D2|rigid:M2/qyH1XBR9A1IxxD7tEYky5Dj8	false	sufficient binding region:9-225	sufficient binding region:1-188	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99N57	uniprotkb:P32883-2	intact:EBI-397757|ensembl:ENSMUSP00000000451|ensembl:ENSMUSP00000108571|uniprotkb:Q3UR68|uniprotkb:Q58E75|uniprotkb:Q99N58|uniprotkb:Q9QUU8|uniprotkb:Q91WH1	intact:EBI-644285|uniprotkb:P08643-1|ensembl:ENSMUSP00000032399	psi-mi:raf1_mouse(display_long)|uniprotkb:Raf1(gene name)|psi-mi:Raf1(display_short)|uniprotkb:Craf(gene name synonym)|uniprotkb:Proto-oncogene c-RAF(gene name synonym)|uniprotkb:Raf-1(gene name synonym)	psi-mi:p32883-2(display_long)|uniprotkb:Kras(gene name)|psi-mi:Kras(display_short)|uniprotkb:Kras2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652311	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0046872"(metal ion binding)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048538"(thymus development)|go:"GO:0060324"(face development)|go:"GO:0071550"(death-inducing signaling complex assembly)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035773"(insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045104"(intermediate filament cytoskeleton organization)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902042"(negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020454|interpro:IPR029071|reactome:R-MMU-2672351|reactome:R-MMU-392517|reactome:R-MMU-430116|reactome:R-MMU-5621575|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|ensembl:ENSMUSG00000000441(gene)|ensembl:ENSMUST00000000451(transcript)|ensembl:ENSMUST00000112949(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0007507"(heart development)|go:"GO:0008179"(adenylate cyclase binding)|refseq:NP_084056.1|refseq:XP_006505426.1|refseq:XP_006505427.1|refseq:XP_006505428.1|dip:DIP-31555N	intact:EBI-644267(rask_mouse)|ensembl:ENSMUSG00000030265(gene)|ensembl:ENSMUST00000032399(transcript)	afcs:34274(primary-reference)|afcs:6639(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FWjmgYQQijkiYwX+3kKeYh6xfNA10090	rogid:QQ2jCFyfJfOiwuQ4vrh9ZZ0C0y810090	intact-crc:30CD513591BAEBD2|rigid:M2/qyH1XBR9A1IxxD7tEYky5Dj8	false	sufficient binding region:38-311	sufficient binding region:1-188	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R4X3	uniprotkb:P25918	intact:EBI-643560|uniprotkb:Q8K373|uniprotkb:Q8R302|uniprotkb:Q9CS80|uniprotkb:B6ICZ5|uniprotkb:Q3TKT7|uniprotkb:Q7TT14|ensembl:ENSMUSP00000050461|ensembl:ENSMUSP00000105233	intact:EBI-644463|uniprotkb:Q542B2|ensembl:ENSMUSP00000145803	psi-mi:rbm12_mouse(display_long)|uniprotkb:RNA-binding motif protein 12(gene name synonym)|uniprotkb:SH3/WW domain anchor protein in the nucleus(gene name synonym)|uniprotkb:Rbm12(gene name)|psi-mi:Rbm12(display_short)	psi-mi:cd19_mouse(display_long)|uniprotkb:Differentiation antigen CD19(gene name synonym)|uniprotkb:Cd19(gene name)|psi-mi:Cd19(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652342	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083673.3|refseq:NP_733486.2|ensembl:ENSMUSG00000089824(gene)|ensembl:ENSMUST00000109604(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034591|interpro:IPR034594|interpro:IPR034854|interpro:IPR034855|interpro:IPR034856|interpro:IPR035979|rcsb pdb:2CQP|ensembl:ENSMUST00000059647(transcript)	refseq:NP_033974.2|ensembl:ENSMUSG00000030724(gene)|ensembl:ENSMUST00000206325(transcript)|go:"GO:0001923"(B-1 B cell differentiation)|go:"GO:0002322"(B cell proliferation involved in immune response)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045121"(membrane raft)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0050864"(regulation of B cell activation)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036179|interpro:IPR042341|reactome:R-MMU-1257604|reactome:R-MMU-198933|reactome:R-MMU-6811558|reactome:R-MMU-977606|reactome:R-MMU-983695|refseq:XP_006507346.1	afcs:15792(primary-reference)|afcs:34969(secondary-ac)	-	-	caution:The prey construct contains 12 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:R/okh5JGU0qFpNksZevcR1MUN1w10090	rogid:YWZCIrT3MOdFhZd5+gTZhMkF8yc10090	intact-crc:17FD8D61A5FEB270|rigid:S22TZJh2Sjhkm5m/nBFOxwF8qcw	false	sufficient binding region:1-154	sufficient binding region:120-286	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60778	uniprotkb:Q04207	intact:EBI-644469|uniprotkb:Q564F1|uniprotkb:Q9D6L5|ensembl:ENSMUSP00000032815|ensembl:ENSMUSP00000083012	intact:EBI-644400|uniprotkb:Q62025|ensembl:ENSMUSP00000025867	psi-mi:ikbb_mouse(display_long)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Nfkbib(gene name)|psi-mi:Nfkbib(display_short)|uniprotkb:Ikbb(gene name synonym)	psi-mi:tf65_mouse(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Rela(gene name)|psi-mi:Rela(display_short)|uniprotkb:Nfkb3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652353	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035038.2|ensembl:ENSMUSG00000030595(gene)|ensembl:ENSMUST00000032815(transcript)|ensembl:ENSMUST00000085851(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q60778|rcsb pdb:1K3Z|rcsb pdb:1OY3|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-445989|reactome:R-MMU-933542|refseq:NP_001293151.1|dip:DIP-37418N	refseq:NP_033071.1|reactome:R-MMU-2871837|reactome:R-MMU-3134963|reactome:R-MMU-3214841|reactome:R-MMU-445989|reactome:R-MMU-448706|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5621575|reactome:R-MMU-9020702|reactome:R-MMU-933542|rcsb pdb:2RAM|rcsb pdb:5U01|rcsb pdb:6GGR|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-209560|ensembl:ENSMUSG00000024927(gene)|ensembl:ENSMUST00000025867(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|mint:Q04207|rcsb pdb:1BFT|rcsb pdb:1IKN|rcsb pdb:1K3Z|rcsb pdb:1LE5|rcsb pdb:1LE9|rcsb pdb:1LEI|rcsb pdb:1MY5|rcsb pdb:1MY7|rcsb pdb:1OY3|rcsb pdb:1RAM|interpro:IPR037059|rcsb pdb:1VKX|rcsb pdb:2I9T|rcsb pdb:2LWW|dip:DIP-6219N	afcs:12430(primary-reference)|afcs:16467(secondary-ac)	-	-	caution:The prey construct contains 15 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ldopxAYCbS48KB25XbB+cotR8Rk10090	rogid:poiJSPJwXK2Om5pfk8z5HwFgK1o10090	intact-crc:E687C9729326847A|rigid:25BEKjozDS2XyDOVB1i7tJq1zRU	false	sufficient binding region:1-359	sufficient binding region:200-430	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60778	uniprotkb:Q04207	intact:EBI-644469|uniprotkb:Q564F1|uniprotkb:Q9D6L5|ensembl:ENSMUSP00000032815|ensembl:ENSMUSP00000083012	intact:EBI-644400|uniprotkb:Q62025|ensembl:ENSMUSP00000025867	psi-mi:ikbb_mouse(display_long)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Nfkbib(gene name)|psi-mi:Nfkbib(display_short)|uniprotkb:Ikbb(gene name synonym)	psi-mi:tf65_mouse(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Rela(gene name)|psi-mi:Rela(display_short)|uniprotkb:Nfkb3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652363	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035038.2|ensembl:ENSMUSG00000030595(gene)|ensembl:ENSMUST00000032815(transcript)|ensembl:ENSMUST00000085851(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q60778|rcsb pdb:1K3Z|rcsb pdb:1OY3|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-445989|reactome:R-MMU-933542|refseq:NP_001293151.1|dip:DIP-37418N	refseq:NP_033071.1|reactome:R-MMU-2871837|reactome:R-MMU-3134963|reactome:R-MMU-3214841|reactome:R-MMU-445989|reactome:R-MMU-448706|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5621575|reactome:R-MMU-9020702|reactome:R-MMU-933542|rcsb pdb:2RAM|rcsb pdb:5U01|rcsb pdb:6GGR|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-209560|ensembl:ENSMUSG00000024927(gene)|ensembl:ENSMUST00000025867(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|mint:Q04207|rcsb pdb:1BFT|rcsb pdb:1IKN|rcsb pdb:1K3Z|rcsb pdb:1LE5|rcsb pdb:1LE9|rcsb pdb:1LEI|rcsb pdb:1MY5|rcsb pdb:1MY7|rcsb pdb:1OY3|rcsb pdb:1RAM|interpro:IPR037059|rcsb pdb:1VKX|rcsb pdb:2I9T|rcsb pdb:2LWW|dip:DIP-6219N	afcs:12430(primary-reference)|afcs:16467(secondary-ac)	-	-	caution:The prey construct contains 13 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ldopxAYCbS48KB25XbB+cotR8Rk10090	rogid:poiJSPJwXK2Om5pfk8z5HwFgK1o10090	intact-crc:F7C2D9B2ED237BD8|rigid:25BEKjozDS2XyDOVB1i7tJq1zRU	false	sufficient binding region:1-359	sufficient binding region:200-430	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60778	uniprotkb:Q04207	intact:EBI-644469|uniprotkb:Q564F1|uniprotkb:Q9D6L5|ensembl:ENSMUSP00000032815|ensembl:ENSMUSP00000083012	intact:EBI-644400|uniprotkb:Q62025|ensembl:ENSMUSP00000025867	psi-mi:ikbb_mouse(display_long)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Nfkbib(gene name)|psi-mi:Nfkbib(display_short)|uniprotkb:Ikbb(gene name synonym)	psi-mi:tf65_mouse(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Rela(gene name)|psi-mi:Rela(display_short)|uniprotkb:Nfkb3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652374	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035038.2|ensembl:ENSMUSG00000030595(gene)|ensembl:ENSMUST00000032815(transcript)|ensembl:ENSMUST00000085851(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q60778|rcsb pdb:1K3Z|rcsb pdb:1OY3|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-445989|reactome:R-MMU-933542|refseq:NP_001293151.1|dip:DIP-37418N	refseq:NP_033071.1|reactome:R-MMU-2871837|reactome:R-MMU-3134963|reactome:R-MMU-3214841|reactome:R-MMU-445989|reactome:R-MMU-448706|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5621575|reactome:R-MMU-9020702|reactome:R-MMU-933542|rcsb pdb:2RAM|rcsb pdb:5U01|rcsb pdb:6GGR|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-209560|ensembl:ENSMUSG00000024927(gene)|ensembl:ENSMUST00000025867(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|mint:Q04207|rcsb pdb:1BFT|rcsb pdb:1IKN|rcsb pdb:1K3Z|rcsb pdb:1LE5|rcsb pdb:1LE9|rcsb pdb:1LEI|rcsb pdb:1MY5|rcsb pdb:1MY7|rcsb pdb:1OY3|rcsb pdb:1RAM|interpro:IPR037059|rcsb pdb:1VKX|rcsb pdb:2I9T|rcsb pdb:2LWW|dip:DIP-6219N	afcs:12430(primary-reference)|afcs:16467(secondary-ac)	-	-	caution:The prey construct contains 11 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ldopxAYCbS48KB25XbB+cotR8Rk10090	rogid:poiJSPJwXK2Om5pfk8z5HwFgK1o10090	intact-crc:C5F1BFEC69DD7A92|rigid:25BEKjozDS2XyDOVB1i7tJq1zRU	false	sufficient binding region:1-186	sufficient binding region:200-430	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60778	uniprotkb:Q04207	intact:EBI-644469|uniprotkb:Q564F1|uniprotkb:Q9D6L5|ensembl:ENSMUSP00000032815|ensembl:ENSMUSP00000083012	intact:EBI-644400|uniprotkb:Q62025|ensembl:ENSMUSP00000025867	psi-mi:ikbb_mouse(display_long)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Nfkbib(gene name)|psi-mi:Nfkbib(display_short)|uniprotkb:Ikbb(gene name synonym)	psi-mi:tf65_mouse(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Rela(gene name)|psi-mi:Rela(display_short)|uniprotkb:Nfkb3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652385	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035038.2|ensembl:ENSMUSG00000030595(gene)|ensembl:ENSMUST00000032815(transcript)|ensembl:ENSMUST00000085851(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q60778|rcsb pdb:1K3Z|rcsb pdb:1OY3|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-445989|reactome:R-MMU-933542|refseq:NP_001293151.1|dip:DIP-37418N	refseq:NP_033071.1|reactome:R-MMU-2871837|reactome:R-MMU-3134963|reactome:R-MMU-3214841|reactome:R-MMU-445989|reactome:R-MMU-448706|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5621575|reactome:R-MMU-9020702|reactome:R-MMU-933542|rcsb pdb:2RAM|rcsb pdb:5U01|rcsb pdb:6GGR|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-209560|ensembl:ENSMUSG00000024927(gene)|ensembl:ENSMUST00000025867(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|mint:Q04207|rcsb pdb:1BFT|rcsb pdb:1IKN|rcsb pdb:1K3Z|rcsb pdb:1LE5|rcsb pdb:1LE9|rcsb pdb:1LEI|rcsb pdb:1MY5|rcsb pdb:1MY7|rcsb pdb:1OY3|rcsb pdb:1RAM|interpro:IPR037059|rcsb pdb:1VKX|rcsb pdb:2I9T|rcsb pdb:2LWW|dip:DIP-6219N	afcs:12430(primary-reference)|afcs:16467(secondary-ac)	-	-	caution:The prey construct contains 9 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ldopxAYCbS48KB25XbB+cotR8Rk10090	rogid:poiJSPJwXK2Om5pfk8z5HwFgK1o10090	intact-crc:BF4726DD8BA86AFF|rigid:25BEKjozDS2XyDOVB1i7tJq1zRU	false	sufficient binding region:1-187	sufficient binding region:200-430	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60778	uniprotkb:Q04207	intact:EBI-644469|uniprotkb:Q564F1|uniprotkb:Q9D6L5|ensembl:ENSMUSP00000032815|ensembl:ENSMUSP00000083012	intact:EBI-644400|uniprotkb:Q62025|ensembl:ENSMUSP00000025867	psi-mi:ikbb_mouse(display_long)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Nfkbib(gene name)|psi-mi:Nfkbib(display_short)|uniprotkb:Ikbb(gene name synonym)	psi-mi:tf65_mouse(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Rela(gene name)|psi-mi:Rela(display_short)|uniprotkb:Nfkb3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652395	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035038.2|ensembl:ENSMUSG00000030595(gene)|ensembl:ENSMUST00000032815(transcript)|ensembl:ENSMUST00000085851(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q60778|rcsb pdb:1K3Z|rcsb pdb:1OY3|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-445989|reactome:R-MMU-933542|refseq:NP_001293151.1|dip:DIP-37418N	refseq:NP_033071.1|reactome:R-MMU-2871837|reactome:R-MMU-3134963|reactome:R-MMU-3214841|reactome:R-MMU-445989|reactome:R-MMU-448706|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5621575|reactome:R-MMU-9020702|reactome:R-MMU-933542|rcsb pdb:2RAM|rcsb pdb:5U01|rcsb pdb:6GGR|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-209560|ensembl:ENSMUSG00000024927(gene)|ensembl:ENSMUST00000025867(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|mint:Q04207|rcsb pdb:1BFT|rcsb pdb:1IKN|rcsb pdb:1K3Z|rcsb pdb:1LE5|rcsb pdb:1LE9|rcsb pdb:1LEI|rcsb pdb:1MY5|rcsb pdb:1MY7|rcsb pdb:1OY3|rcsb pdb:1RAM|interpro:IPR037059|rcsb pdb:1VKX|rcsb pdb:2I9T|rcsb pdb:2LWW|dip:DIP-6219N	afcs:12430(primary-reference)|afcs:16467(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ldopxAYCbS48KB25XbB+cotR8Rk10090	rogid:poiJSPJwXK2Om5pfk8z5HwFgK1o10090	intact-crc:4EBB9A93CBDFDFC9|rigid:25BEKjozDS2XyDOVB1i7tJq1zRU	false	sufficient binding region:4-359	sufficient binding region:200-430	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60778	uniprotkb:Q04207	intact:EBI-644469|uniprotkb:Q564F1|uniprotkb:Q9D6L5|ensembl:ENSMUSP00000032815|ensembl:ENSMUSP00000083012	intact:EBI-644400|uniprotkb:Q62025|ensembl:ENSMUSP00000025867	psi-mi:ikbb_mouse(display_long)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Nfkbib(gene name)|psi-mi:Nfkbib(display_short)|uniprotkb:Ikbb(gene name synonym)	psi-mi:tf65_mouse(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Rela(gene name)|psi-mi:Rela(display_short)|uniprotkb:Nfkb3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652405	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035038.2|ensembl:ENSMUSG00000030595(gene)|ensembl:ENSMUST00000032815(transcript)|ensembl:ENSMUST00000085851(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q60778|rcsb pdb:1K3Z|rcsb pdb:1OY3|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-445989|reactome:R-MMU-933542|refseq:NP_001293151.1|dip:DIP-37418N	refseq:NP_033071.1|reactome:R-MMU-2871837|reactome:R-MMU-3134963|reactome:R-MMU-3214841|reactome:R-MMU-445989|reactome:R-MMU-448706|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5621575|reactome:R-MMU-9020702|reactome:R-MMU-933542|rcsb pdb:2RAM|rcsb pdb:5U01|rcsb pdb:6GGR|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-209560|ensembl:ENSMUSG00000024927(gene)|ensembl:ENSMUST00000025867(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|mint:Q04207|rcsb pdb:1BFT|rcsb pdb:1IKN|rcsb pdb:1K3Z|rcsb pdb:1LE5|rcsb pdb:1LE9|rcsb pdb:1LEI|rcsb pdb:1MY5|rcsb pdb:1MY7|rcsb pdb:1OY3|rcsb pdb:1RAM|interpro:IPR037059|rcsb pdb:1VKX|rcsb pdb:2I9T|rcsb pdb:2LWW|dip:DIP-6219N	afcs:12430(primary-reference)|afcs:16467(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ldopxAYCbS48KB25XbB+cotR8Rk10090	rogid:poiJSPJwXK2Om5pfk8z5HwFgK1o10090	intact-crc:407A546FCB8B5E9A|rigid:25BEKjozDS2XyDOVB1i7tJq1zRU	false	sufficient binding region:27-357	sufficient binding region:200-430	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60778	uniprotkb:Q04207	intact:EBI-644469|uniprotkb:Q564F1|uniprotkb:Q9D6L5|ensembl:ENSMUSP00000032815|ensembl:ENSMUSP00000083012	intact:EBI-644400|uniprotkb:Q62025|ensembl:ENSMUSP00000025867	psi-mi:ikbb_mouse(display_long)|uniprotkb:I-kappa-B-beta(gene name synonym)|uniprotkb:Nfkbib(gene name)|psi-mi:Nfkbib(display_short)|uniprotkb:Ikbb(gene name synonym)	psi-mi:tf65_mouse(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Rela(gene name)|psi-mi:Rela(display_short)|uniprotkb:Nfkb3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652415	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035038.2|ensembl:ENSMUSG00000030595(gene)|ensembl:ENSMUST00000032815(transcript)|ensembl:ENSMUST00000085851(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007165"(signal transduction)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0071222"(cellular response to lipopolysaccharide)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q60778|rcsb pdb:1K3Z|rcsb pdb:1OY3|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-445989|reactome:R-MMU-933542|refseq:NP_001293151.1|dip:DIP-37418N	refseq:NP_033071.1|reactome:R-MMU-2871837|reactome:R-MMU-3134963|reactome:R-MMU-3214841|reactome:R-MMU-445989|reactome:R-MMU-448706|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5621575|reactome:R-MMU-9020702|reactome:R-MMU-933542|rcsb pdb:2RAM|rcsb pdb:5U01|rcsb pdb:6GGR|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-209560|ensembl:ENSMUSG00000024927(gene)|ensembl:ENSMUST00000025867(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|mint:Q04207|rcsb pdb:1BFT|rcsb pdb:1IKN|rcsb pdb:1K3Z|rcsb pdb:1LE5|rcsb pdb:1LE9|rcsb pdb:1LEI|rcsb pdb:1MY5|rcsb pdb:1MY7|rcsb pdb:1OY3|rcsb pdb:1RAM|interpro:IPR037059|rcsb pdb:1VKX|rcsb pdb:2I9T|rcsb pdb:2LWW|dip:DIP-6219N	afcs:12430(primary-reference)|afcs:16467(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ldopxAYCbS48KB25XbB+cotR8Rk10090	rogid:poiJSPJwXK2Om5pfk8z5HwFgK1o10090	intact-crc:FC5D975591977AF3|rigid:25BEKjozDS2XyDOVB1i7tJq1zRU	false	sufficient binding region:48-244	sufficient binding region:200-430	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JJU6	uniprotkb:P32883-2	intact:EBI-644476	intact:EBI-644285|uniprotkb:P08643-1|ensembl:ENSMUSP00000032399	psi-mi:q9jju6_mouse(display_long)|uniprotkb:Braf(gene name)|psi-mi:Braf(display_short)|uniprotkb:B-raf(gene name synonym)	psi-mi:p32883-2(display_long)|uniprotkb:Kras(gene name)|psi-mi:Kras(display_short)|uniprotkb:Kras2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652425	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR020454|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003116(Raf-like Ras-binding)|interpro:IPR029071|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"	intact:EBI-644267(rask_mouse)|ensembl:ENSMUSG00000030265(gene)|ensembl:ENSMUST00000032399(transcript)	afcs:34274(primary-reference)|afcs:39331(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:nxR45n838esMO4NALWDBiI8ikTY10090	rogid:QQ2jCFyfJfOiwuQ4vrh9ZZ0C0y810090	intact-crc:8A959733C703B812|rigid:RM1b3PSkfI0L0EVYvF+il5HNcNA	false	sufficient binding region:11-218	sufficient binding region:1-188	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P42337	uniprotkb:P26450	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648730	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:15011(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:FFD490DE8CD27AE4|rigid:5MXFlA9qywcfB/6z9jJcOYhUONo	false	sufficient binding region:1-105	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35904	uniprotkb:P26450	intact:EBI-647932|uniprotkb:Q8CJ28|ensembl:ENSMUSP00000101314	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:pk3cd_mouse(display_long)|uniprotkb:Pik3cd(gene name)|psi-mi:Pik3cd(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit delta(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659033	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001157524.1|refseq:XP_006538715.1|dip:DIP-39841N|ensembl:ENSMUSG00000039936(gene)|ensembl:ENSMUST00000105689(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030154"(cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0042113"(B cell activation)|go:"GO:0045087"(innate immune response)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050832"(defense response to fungus)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:1905278"(positive regulation of epithelial tube formation)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037703|interpro:IPR042236|rcsb pdb:2WXF|rcsb pdb:2WXG|rcsb pdb:2WXH|rcsb pdb:2WXI|rcsb pdb:2WXJ|rcsb pdb:2WXK|rcsb pdb:2WXL|rcsb pdb:2WXM|rcsb pdb:2WXN|rcsb pdb:2WXO|rcsb pdb:2WXP|rcsb pdb:2WXQ|rcsb pdb:2WXR|rcsb pdb:2X38|rcsb pdb:4AJW|rcsb pdb:4V0I|rcsb pdb:4XE0|rcsb pdb:5AE8|rcsb pdb:5AE9|rcsb pdb:5I4U|rcsb pdb:5I6U|rcsb pdb:5IS5|rcsb pdb:5L72|rcsb pdb:5NCY|rcsb pdb:5NCZ|rcsb pdb:5NGB|rcsb pdb:5O83|rcsb pdb:5T27|rcsb pdb:5T28|rcsb pdb:5T2B|rcsb pdb:5T2D|rcsb pdb:5T2G|rcsb pdb:5T2I|rcsb pdb:5T2L|rcsb pdb:5T2M|rcsb pdb:5T7F|rcsb pdb:5T8I|rcsb pdb:6DGT|rcsb pdb:6EYZ|rcsb pdb:6EZ6|rcsb pdb:6GY0|rcsb pdb:6HI9|rcsb pdb:6MUL|rcsb pdb:6MUM|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-512988|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-983695	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:53645(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mcGmhHve+Mi2DhcQ7akqBFC0OfI10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:C59182D90AD283BF|rigid:R7IgXWQioB87Bxqmnzcu7hTlUYA	false	sufficient binding region:7-336	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P55937	uniprotkb:P26450	intact:EBI-647945|uniprotkb:Q80VF5|uniprotkb:Q8CCK4|uniprotkb:Q9QYT2|uniprotkb:Q9QYT3	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:goga3_mouse(display_long)|uniprotkb:Golgin-160(gene name synonym)|uniprotkb:Male-enhanced antigen 2(gene name synonym)|uniprotkb:Golga3(gene name)|psi-mi:Golga3(display_short)|uniprotkb:Mea2(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659043	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032172.3|interpro:IPR033288|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0030154"(cell differentiation)|go:"GO:0032580"(Golgi cisterna membrane)|go:"GO:0090498"(extrinsic component of Golgi membrane)|reactome:R-MMU-9696270|go:"GO:0007283"(spermatogenesis)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:14443(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:M2jyN71/zrgSF7nm1pYVLtWr9G410090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:9EE2268EDB4E8383|rigid:jWVNSSqP72GJ8v6sQop0jMkowJ8	false	sufficient binding region:406-555	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62448	uniprotkb:P26450	intact:EBI-296494|uniprotkb:P97867|uniprotkb:Q0VGZ3|uniprotkb:Q3UNC1|uniprotkb:Q5XKD8|uniprotkb:Q6P1Z0|uniprotkb:Q921U3	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:if4g2_mouse(display_long)|uniprotkb:Eif4g2(gene name)|psi-mi:Eif4g2(display_short)|uniprotkb:Nat1(gene name synonym)|uniprotkb:p97(gene name synonym)|uniprotkb:Novel APOBEC-1 target 1(gene name synonym)|uniprotkb:Translation repressor NAT1(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659053	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030424"(axon)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0060999"(positive regulation of dendritic spine development)|reactome:R-MMU-1169408|go:"GO:0034645"(cellular macromolecule biosynthetic process)|refseq:NP_001035221.1|refseq:NP_038535.2|interpro:IPR016024(Armadillo-type fold)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|mint:Q62448	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17233(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Mv7bkccswjA/XXuUQFVSD550aO010090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:CDC951C4BC4381BD|rigid:Ioh1Ux0Hj3ClQhi7wql0mtBg2KI	false	sufficient binding region:314-713	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62448	uniprotkb:P26450	intact:EBI-296494|uniprotkb:P97867|uniprotkb:Q0VGZ3|uniprotkb:Q3UNC1|uniprotkb:Q5XKD8|uniprotkb:Q6P1Z0|uniprotkb:Q921U3	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:if4g2_mouse(display_long)|uniprotkb:Eif4g2(gene name)|psi-mi:Eif4g2(display_short)|uniprotkb:Nat1(gene name synonym)|uniprotkb:p97(gene name synonym)|uniprotkb:Novel APOBEC-1 target 1(gene name synonym)|uniprotkb:Translation repressor NAT1(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659063	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030424"(axon)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0060999"(positive regulation of dendritic spine development)|reactome:R-MMU-1169408|go:"GO:0034645"(cellular macromolecule biosynthetic process)|refseq:NP_001035221.1|refseq:NP_038535.2|interpro:IPR016024(Armadillo-type fold)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|mint:Q62448	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17233(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Mv7bkccswjA/XXuUQFVSD550aO010090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:C11EAE67F45131B8|rigid:Ioh1Ux0Hj3ClQhi7wql0mtBg2KI	false	sufficient binding region:349-697	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62448	uniprotkb:P26450	intact:EBI-296494|uniprotkb:P97867|uniprotkb:Q0VGZ3|uniprotkb:Q3UNC1|uniprotkb:Q5XKD8|uniprotkb:Q6P1Z0|uniprotkb:Q921U3	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:if4g2_mouse(display_long)|uniprotkb:Eif4g2(gene name)|psi-mi:Eif4g2(display_short)|uniprotkb:Nat1(gene name synonym)|uniprotkb:p97(gene name synonym)|uniprotkb:Novel APOBEC-1 target 1(gene name synonym)|uniprotkb:Translation repressor NAT1(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659073	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030424"(axon)|go:"GO:0003729"(mRNA binding)|go:"GO:0003743"(translation initiation factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008135"(translation factor activity, RNA binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016281"(eukaryotic translation initiation factor 4F complex)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0060999"(positive regulation of dendritic spine development)|reactome:R-MMU-1169408|go:"GO:0034645"(cellular macromolecule biosynthetic process)|refseq:NP_001035221.1|refseq:NP_038535.2|interpro:IPR016024(Armadillo-type fold)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR003891(Initiation factor eIF-4 gamma, MA3)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR016021(MIF4-like, type 1/2/3)|mint:Q62448	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17233(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Mv7bkccswjA/XXuUQFVSD550aO010090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:B1976180CFE955E9|rigid:Ioh1Ux0Hj3ClQhi7wql0mtBg2KI	false	sufficient binding region:534-698	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P31695	uniprotkb:Q60591	intact:EBI-643670|uniprotkb:O35442|uniprotkb:O88314|uniprotkb:O88316|uniprotkb:Q62389|uniprotkb:Q62390|uniprotkb:Q9R1W9|uniprotkb:Q9R1X0|ensembl:ENSMUSP00000015612|uniprotkb:A2CG28	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:notc4_mouse(display_long)|uniprotkb:Notch4(gene name)|psi-mi:Notch4(display_short)|uniprotkb:Int3(gene name synonym)|uniprotkb:Int-3(gene name synonym)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651372	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035059.2|ensembl:ENSMUSG00000015468(gene)|ensembl:ENSMUST00000015612(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001763"(morphogenesis of a branching structure)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0001944"(vasculature development)|go:"GO:0005112"(Notch binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0008593"(regulation of Notch signaling pathway)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030879"(mammary gland development)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0045446"(endothelial cell differentiation)|go:"GO:0045602"(negative regulation of endothelial cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048845"(venous blood vessel morphogenesis)|go:"GO:0060354"(negative regulation of cell adhesion molecule production)|go:"GO:0070613"(regulation of protein processing)|go:"GO:1903849"(positive regulation of aorta morphogenesis)|go:"GO:2000048"(negative regulation of cell-cell adhesion mediated by cadherin)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR000800(Notch region)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR002110(Ankyrin)|interpro:IPR008297(Notch)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR010660(Notch, NOD region)|interpro:IPR011656(Notch, NODP region)|interpro:IPR013032(EGF-like region, conserved site)|interpro:IPR018097|interpro:IPR020683|interpro:IPR022355|interpro:IPR035993|interpro:IPR036770|reactome:R-MMU-1912420|reactome:R-MMU-350054|reactome:R-MMU-9013700|reactome:R-MMU-9604323	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	afcs:53032(primary-reference)|afcs:53073(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2019/04/15	rogid:VJKBo9EopPR5o/YNqRqsKIMH4T410090	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	intact-crc:03BECD14D1FFD9A1|rigid:7DJD8yKYkfZRyef52Ks/mjqMto4	false	sufficient binding region:1510-1686	sufficient binding region:200-451	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BKC5	uniprotkb:P70315	intact:EBI-643605|uniprotkb:Q3TEG2|uniprotkb:Q7TQC6|uniprotkb:Q9EQ30|ensembl:ENSMUSP00000032898	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:ipo5_mouse(display_long)|uniprotkb:Ranbp5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)|uniprotkb:Ipo5(gene name)|psi-mi:Ipo5(display_short)|uniprotkb:Kpnb3(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652177	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076068.1|refseq:XP_006519603.1|ensembl:ENSMUSG00000030662(gene)|ensembl:ENSMUST00000032898(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:Q8BKC5|go:"GO:0006607"(NLS-bearing protein import into nucleus)	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:20927(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZtMfEhsr1lfJDBglaNlc7j4GHZ010090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:43E762320B0B9390|rigid:cMIi1q2ZNGRABeCDJY1zPoYG7sE	false	sufficient binding region:719-1056	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28652	uniprotkb:P11798-2	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652672	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:13970(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:1F0781ADB0DC0E2D|rigid:PoTRDU+6xxjGnp32SL74L0M4JWU	false	sufficient binding region:307-500	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35991	uniprotkb:P70315	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652988	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:17216(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:C4E55DBEB66C8A56|rigid:APihz72KkgxqHy1b9AcramPkzSw	false	sufficient binding region:137-300	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JK42	uniprotkb:O08908	intact:EBI-643530|uniprotkb:Q8VC63|ensembl:ENSMUSP00000041447	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:pdk2_mouse(display_long)|uniprotkb:Pyruvate dehydrogenase kinase isoform 2(gene name synonym)|uniprotkb:Pdk2(gene name)|psi-mi:Pdk2(display_short)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651275	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598428.2|ensembl:ENSMUSG00000038967(gene)|ensembl:ENSMUST00000038431(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006885"(regulation of pH)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR018955|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:Q9JK42|reactome:R-MMU-204174|reactome:R-MMU-5362517|interpro:IPR005467(Signal transduction histidine kinase, core)	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:34667(secondary-ac)	-	-	caution:The prey construct contains 19 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:D23zOk9wYjzMwMQYSgquxlE6XVc10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:7E00DAB24A1BF891|rigid:6U4qbZ56o0gVz0f1S5hMnp5A9BU	false	sufficient binding region:1-118	sufficient binding region:397-624	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JK42	uniprotkb:O08908	intact:EBI-643530|uniprotkb:Q8VC63|ensembl:ENSMUSP00000041447	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:pdk2_mouse(display_long)|uniprotkb:Pyruvate dehydrogenase kinase isoform 2(gene name synonym)|uniprotkb:Pdk2(gene name)|psi-mi:Pdk2(display_short)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651287	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598428.2|ensembl:ENSMUSG00000038967(gene)|ensembl:ENSMUST00000038431(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006885"(regulation of pH)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR018955|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:Q9JK42|reactome:R-MMU-204174|reactome:R-MMU-5362517|interpro:IPR005467(Signal transduction histidine kinase, core)	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:34667(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:D23zOk9wYjzMwMQYSgquxlE6XVc10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:5A6624D9828A62C2|rigid:6U4qbZ56o0gVz0f1S5hMnp5A9BU	false	sufficient binding region:47-397	sufficient binding region:397-624	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88667	uniprotkb:P63001	intact:EBI-644210	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:rad_mouse(display_long)|uniprotkb:Rrad(gene name)|psi-mi:Rrad(display_short)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651831	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001806(Ras GTPase)|interpro:IPR017358(GTP-binding, GEM/REM/Rad)|go:"GO:0003924"(GTPase activity)|go:"GO:0005246"(calcium channel regulator activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005525"(GTP binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:1901842"(negative regulation of high voltage-gated calcium channel activity)|interpro:IPR028869|interpro:IPR027417	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	afcs:23265(primary-reference)|afcs:18188(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:cK0MN1iTJVtcyPSHp4YMXdB38ps10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:902067D4CC425617|rigid:vkk9xUUF37lQD9xgJ+tL/FcrI/A	false	sufficient binding region:11-123	sufficient binding region:50-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26450	uniprotkb:P42337	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	intact:EBI-641748|uniprotkb:Q0VGQ5|ensembl:ENSMUSP00000029201|ensembl:ENSMUSP00000103878	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:pk3ca_mouse(display_long)|uniprotkb:Phosphoinositide-3-kinase catalytic alpha polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CA(gene name synonym)|uniprotkb:Pik3ca(gene name)|psi-mi:Pik3ca(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648700	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	refseq:NP_032865.2|refseq:XP_006535472.1|dip:DIP-32095N|refseq:XP_006535473.1|ensembl:ENSMUSG00000027665(gene)|ensembl:ENSMUST00000029201(transcript)|ensembl:ENSMUST00000108243(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001889"(liver development)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006909"(phagocytosis)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030295"(protein kinase activator activity)|go:"GO:0030835"(negative regulation of actin filament depolymerization)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-198203|reactome:R-MMU-9009391|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-202424|reactome:R-MMU-9027276|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-2424491|reactome:R-MMU-9607240|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|go:"GO:0060612"(adipose tissue development)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071464"(cellular response to hydrostatic pressure)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0097009"(energy homeostasis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0110053"(regulation of actin filament organization)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|go:"GO:2000653"(regulation of genetic imprinting)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|go:"GO:0055119"(relaxation of cardiac muscle)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037704|interpro:IPR042236|rcsb pdb:4A55|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|go:"GO:0043457"(regulation of cellular respiration)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044029"(hypomethylation of CpG island)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0040014"(regulation of multicellular organism growth)	afcs:15011(primary-reference)|afcs:52679(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	rogid:+gXu6JFdbzl5KmSwStQ18RDmkWw10090	intact-crc:3889B6ECAFBDDC02|rigid:5MXFlA9qywcfB/6z9jJcOYhUONo	false	sufficient binding region:374-724	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0DMN7	uniprotkb:P98083	intact:EBI-644529|uniprotkb:P31154|uniprotkb:P82184|uniprotkb:Q58E47|ensembl:ENSMUSP00000097528|ensembl:ENSMUSP00000159133	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:dcam1_mouse(display_long)|uniprotkb:Amd1(gene name)|psi-mi:Amd1(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652466	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033795.1|ensembl:ENSMUSG00000075232(gene)|ensembl:ENSMUST00000099945(transcript)|ensembl:ENSMUST00000238969(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004014"(adenosylmethionine decarboxylase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006557"(S-adenosylmethioninamine biosynthetic process)|go:"GO:0006597"(spermine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0019810"(putrescine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001985(S-adenosylmethionine decarboxylase)|interpro:IPR016067(S-adenosylmethionine decarboxylase, core)|interpro:IPR018166|mint:P0DMN7|reactome:R-MMU-351202	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:15663(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:C6CwoFWtQAiWB9f5Y+g8jKU0b9g10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:06E6552D9C9F3E83|rigid:9oGTPpgkS8E2pdYoS37BLmxR8+M	false	sufficient binding region:124-334	sufficient binding region:1-341	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0DMN7	uniprotkb:P98083	intact:EBI-644529|uniprotkb:P31154|uniprotkb:P82184|uniprotkb:Q58E47|ensembl:ENSMUSP00000097528|ensembl:ENSMUSP00000159133	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:dcam1_mouse(display_long)|uniprotkb:Amd1(gene name)|psi-mi:Amd1(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652488	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033795.1|ensembl:ENSMUSG00000075232(gene)|ensembl:ENSMUST00000099945(transcript)|ensembl:ENSMUST00000238969(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004014"(adenosylmethionine decarboxylase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006557"(S-adenosylmethioninamine biosynthetic process)|go:"GO:0006597"(spermine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0019810"(putrescine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001985(S-adenosylmethionine decarboxylase)|interpro:IPR016067(S-adenosylmethionine decarboxylase, core)|interpro:IPR018166|mint:P0DMN7|reactome:R-MMU-351202	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:15663(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:C6CwoFWtQAiWB9f5Y+g8jKU0b9g10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:153358C36EC05987|rigid:9oGTPpgkS8E2pdYoS37BLmxR8+M	false	sufficient binding region:150-334	sufficient binding region:1-341	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P0DMN7	uniprotkb:P98083	intact:EBI-644529|uniprotkb:P31154|uniprotkb:P82184|uniprotkb:Q58E47|ensembl:ENSMUSP00000097528|ensembl:ENSMUSP00000159133	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:dcam1_mouse(display_long)|uniprotkb:Amd1(gene name)|psi-mi:Amd1(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652498	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033795.1|ensembl:ENSMUSG00000075232(gene)|ensembl:ENSMUST00000099945(transcript)|ensembl:ENSMUST00000238969(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0004014"(adenosylmethionine decarboxylase activity)|go:"GO:0005829"(cytosol)|go:"GO:0006557"(S-adenosylmethioninamine biosynthetic process)|go:"GO:0006597"(spermine biosynthetic process)|go:"GO:0008295"(spermidine biosynthetic process)|go:"GO:0019810"(putrescine binding)|go:"GO:0042802"(identical protein binding)|interpro:IPR001985(S-adenosylmethionine decarboxylase)|interpro:IPR016067(S-adenosylmethionine decarboxylase, core)|interpro:IPR018166|mint:P0DMN7|reactome:R-MMU-351202	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:15663(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:C6CwoFWtQAiWB9f5Y+g8jKU0b9g10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:52BDF689FBC1EEE4|rigid:9oGTPpgkS8E2pdYoS37BLmxR8+M	false	sufficient binding region:168-334	sufficient binding region:1-341	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02248	uniprotkb:P26450	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654291	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:13985(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:7974C1D6B97E57A2|rigid:VGpWE4wkzzBCxeY+GGX1LXKFp7k	false	sufficient binding region:392-781	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654321	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:F2DA667B0E4E97C7|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:362-651	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654331	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:C080E857CA397ECF|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:370-651	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654361	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:5A697D0C01E3742F|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:435-651	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654371	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:3B99633CE38C9621|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:449-651	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654381	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:C06ED09B9624D955|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:463-640	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654391	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:B9C076C4C8568E70|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:464-651	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654401	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:E1145047E9D714AE|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:487-651	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:P26450	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654411	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:391C11BCDF274B18|rigid:hMWZSGqzLqodth9Qj7aydQhW5s4	false	sufficient binding region:494-633	sufficient binding region:420-620	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P98083	intact:EBI-682314	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	-	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:ptn12-afcs_mouse(display_short)|psi-mi:EBI-682314(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688391	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	-	afcs:31945(secondary-ac)|afcs:6875(primary-reference)|afcs:31945(primary-reference)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"similar to mouse P35831 Tyrosine-protein phosphatase, non-receptor type 12 (EC 3.1.3.48)(Protein-tyrosine phosphatase P19) (P19-PTP) (MPTP-PEST)."|comment:"AfCS Y2H protein. Sequence deduced from cross-reference:protein GI:416182"	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	rogid:3BZoZqaw5Ee46QUmraUZLnpbGGY10090	intact-crc:AC65A58E6487031A|rigid:IzUdgqMluJufWD4zNNCS7yYB/TM	false	sufficient binding region:1-341	sufficient binding region:552-773	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1S8	uniprotkb:Q60631	intact:EBI-641738|uniprotkb:Q9R1X3	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:gab2_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 2(gene name synonym)|uniprotkb:GRB2-associated binder 2(gene name synonym)|uniprotkb:PH domain-containing adaptor molecule p97(gene name synonym)|uniprotkb:Gab2(gene name)|psi-mi:Gab2(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648512	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-109704|reactome:R-MMU-1433557|reactome:R-MMU-2730905|reactome:R-MMU-8853659|reactome:R-MMU-912526|dip:DIP-41351N|go:"GO:0005068"(transmembrane receptor protein tyrosine kinase adaptor activity)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043306"(positive regulation of mast cell degranulation)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|reactome:R-MMU-9674555|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-9607240	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:16043(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:DV50jtkpOksZpaqjllQRhmpYkvk10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:8C45053278A44C82|rigid:jxUcaDe25ZuQ9CPbYDfeVHR1i24	false	sufficient binding region:287-579	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O55179	uniprotkb:Q60823	intact:EBI-644620|ensembl:ENSMUSP00000096087	intact:EBI-400263|ensembl:ENSMUSP00000052103|ensembl:ENSMUSP00000103980|ensembl:ENSMUSP00000103981|ensembl:ENSMUSP00000132141	psi-mi:o55179_mouse(display_long)|uniprotkb:Bcl2a1d(gene name)|psi-mi:Bcl2a1d(display_short)|uniprotkb:A1d(gene name synonym)	psi-mi:akt2_mouse(display_long)|uniprotkb:Akt2(gene name)|psi-mi:Akt2(display_short)|uniprotkb:RAC-PK-beta(gene name synonym)|uniprotkb:Protein kinase Akt-2(gene name synonym)|uniprotkb:Protein kinase B beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652630	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031562.1|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|ensembl:ENSMUSG00000099974(gene)|ensembl:ENSMUST00000098486(transcript)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0030217"(T cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001103678.1|refseq:NP_031460.1|refseq:NP_001318037.1|refseq:NP_001318038.1|ensembl:ENSMUSG00000004056(gene)|ensembl:ENSMUST00000051356(transcript)|ensembl:ENSMUST00000108343(transcript)|ensembl:ENSMUST00000108344(transcript)|ensembl:ENSMUST00000167435(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0065002"(intracellular protein transmembrane transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071486"(cellular response to high light intensity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097473"(retinal rod cell apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-MMU-198323|reactome:R-MMU-198693|reactome:R-MMU-199418|reactome:R-MMU-211163|reactome:R-MMU-3769402|reactome:R-MMU-389357|reactome:R-MMU-389513|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-69202|reactome:R-MMU-69656|reactome:R-MMU-8876198|reactome:R-MMU-8948751|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9634638|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034677|interpro:IPR039026|reactome:R-MMU-1257604|reactome:R-MMU-1358803|reactome:R-MMU-165158|reactome:R-MMU-165181|refseq:XP_006539540.1|refseq:XP_006539543.1|refseq:XP_006539544.1	afcs:13804(primary-reference)|afcs:13917(secondary-ac)	-	-	caution:The prey construct contains 21 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Vz37kK0UQf5aDMWrPeETV1B+/wI10090	rogid:GjD2WbRJI+qYjgkoNNxQaGRdHYE10090	intact-crc:032496C98DBB9A7A|rigid:4MR4TcsVsxaCWOI5u3GHdvEyF4M	false	sufficient binding region:1-156	sufficient binding region:100-161	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CRT8	uniprotkb:Q60823	intact:EBI-644629|uniprotkb:Q52KI1|ensembl:ENSMUSP00000043488	intact:EBI-400263|ensembl:ENSMUSP00000052103|ensembl:ENSMUSP00000103980|ensembl:ENSMUSP00000103981|ensembl:ENSMUSP00000132141	psi-mi:xpot_mouse(display_long)|uniprotkb:tRNA exportin(gene name synonym)|uniprotkb:"Exportin(tRNA)"(gene name synonym)|uniprotkb:Xpot(gene name)|psi-mi:Xpot(display_short)	psi-mi:akt2_mouse(display_long)|uniprotkb:Akt2(gene name)|psi-mi:Akt2(display_short)|uniprotkb:RAC-PK-beta(gene name synonym)|uniprotkb:Protein kinase Akt-2(gene name synonym)|uniprotkb:Protein kinase B beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652641	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034667(gene)|ensembl:ENSMUST00000039810(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031267"(small GTPase binding)|go:"GO:0071528"(tRNA re-export from nucleus)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040017|mint:Q9CRT8	refseq:NP_001103678.1|refseq:NP_031460.1|refseq:NP_001318037.1|refseq:NP_001318038.1|ensembl:ENSMUSG00000004056(gene)|ensembl:ENSMUST00000051356(transcript)|ensembl:ENSMUST00000108343(transcript)|ensembl:ENSMUST00000108344(transcript)|ensembl:ENSMUST00000167435(transcript)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0005978"(glycogen biosynthetic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008643"(carbohydrate transport)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010748"(negative regulation of long-chain fatty acid import across plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010907"(positive regulation of glucose metabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031982"(vesicle)|go:"GO:0032000"(positive regulation of fatty acid beta-oxidation)|go:"GO:0032287"(peripheral nervous system myelin maintenance)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032593"(insulin-responsive compartment)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046872"(metal ion binding)|go:"GO:0050927"(positive regulation of positive chemotaxis)|go:"GO:0065002"(intracellular protein transmembrane transport)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071486"(cellular response to high light intensity)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097473"(retinal rod cell apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|reactome:R-MMU-198323|reactome:R-MMU-198693|reactome:R-MMU-199418|reactome:R-MMU-211163|reactome:R-MMU-3769402|reactome:R-MMU-389357|reactome:R-MMU-389513|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5628897|reactome:R-MMU-6804757|reactome:R-MMU-6804758|reactome:R-MMU-6804759|reactome:R-MMU-69202|reactome:R-MMU-69656|reactome:R-MMU-8876198|reactome:R-MMU-8948751|reactome:R-MMU-9607240|reactome:R-MMU-9614399|reactome:R-MMU-9634638|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR034677|interpro:IPR039026|reactome:R-MMU-1257604|reactome:R-MMU-1358803|reactome:R-MMU-165158|reactome:R-MMU-165181|refseq:XP_006539540.1|refseq:XP_006539543.1|refseq:XP_006539544.1	afcs:13804(primary-reference)|afcs:40011(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sxoS4tNMBaRRDwVJM5HlK1c2avE10090	rogid:GjD2WbRJI+qYjgkoNNxQaGRdHYE10090	intact-crc:C4E40CD5705FB144|rigid:EyNw2vSe4pBxAbXQxjLBdaqF0mA	false	sufficient binding region:1-246	sufficient binding region:100-161	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6NVF9	uniprotkb:P11798-2	intact:EBI-644663|uniprotkb:Q8BX86|uniprotkb:Q8BXI8|ensembl:ENSMUSP00000135136|ensembl:ENSMUSP00000068408	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:cpsf6_mouse(display_long)|uniprotkb:Cpsf6(gene name)|psi-mi:Cpsf6(display_short)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652782	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013409.1|refseq:XP_006513921.1|interpro:IPR034772|interpro:IPR035979|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:1990448"(exon-exon junction complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034769|ensembl:ENSMUSG00000055531(gene)|ensembl:ENSMUST00000069168(transcript)|ensembl:ENSMUST00000177145(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005737"(cytoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042382"(paraspeckles)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051262"(protein tetramerization)|dip:DIP-49394N	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:40010(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:vkAL2tagRoSQgMPNzhp1xN5AM7o10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:C1C5E812633CD775|rigid:sNaIrhLjHr+W5jSDiKww5etSSbo	false	sufficient binding region:229-453	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6NVF9	uniprotkb:P11798-2	intact:EBI-644663|uniprotkb:Q8BX86|uniprotkb:Q8BXI8|ensembl:ENSMUSP00000135136|ensembl:ENSMUSP00000068408	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:cpsf6_mouse(display_long)|uniprotkb:Cpsf6(gene name)|psi-mi:Cpsf6(display_short)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652792	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001013409.1|refseq:XP_006513921.1|interpro:IPR034772|interpro:IPR035979|go:"GO:0051290"(protein heterotetramerization)|go:"GO:0098789"(pre-mRNA cleavage required for polyadenylation)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1990120"(messenger ribonucleoprotein complex assembly)|go:"GO:1990448"(exon-exon junction complex binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034769|ensembl:ENSMUSG00000055531(gene)|ensembl:ENSMUST00000069168(transcript)|ensembl:ENSMUST00000177145(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005726"(perichromatin fibrils)|go:"GO:0005737"(cytoplasm)|go:"GO:0005847"(mRNA cleavage and polyadenylation specificity factor complex)|go:"GO:0005849"(mRNA cleavage factor complex)|go:"GO:0006397"(mRNA processing)|go:"GO:0016607"(nuclear speck)|go:"GO:0035061"(interchromatin granule)|go:"GO:0042382"(paraspeckles)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0051262"(protein tetramerization)|dip:DIP-49394N	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:40010(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:vkAL2tagRoSQgMPNzhp1xN5AM7o10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:5140D114CD68ED29|rigid:sNaIrhLjHr+W5jSDiKww5etSSbo	false	sufficient binding region:289-460	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P57759	uniprotkb:Q8BTI9	intact:EBI-644683|uniprotkb:Q3THW3|uniprotkb:Q9CQ42|ensembl:ENSMUSP00000117347	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:erp29_mouse(display_long)|uniprotkb:Erp29(gene name)|psi-mi:Erp29(display_short)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652802	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080405.1|ensembl:ENSMUSG00000029616(gene)|ensembl:ENSMUST00000130451(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0009306"(protein secretion)|go:"GO:0009986"(cell surface)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030133"(transport vesicle)|go:"GO:0042470"(melanosome)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0051087"(chaperone binding)|go:"GO:1902235"(regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|interpro:IPR011679(Endoplasmic reticulum, protein ERp29, C-terminal)|interpro:IPR012883(ERp29, N-terminal)|interpro:IPR016855(Endoplasmic reticulum, protein ERp29)|interpro:IPR036249|interpro:IPR036356|mint:P57759	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	afcs:33521(primary-reference)|afcs:30342(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ENKfK5l3jbtzeqKI2OffVUshqKI10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:E743133C51CECBB3|rigid:4HkIELzWv4nuaBtiilDX9ndrPj8	false	sufficient binding region:54-262	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R0I7	uniprotkb:Q8BTI9	intact:EBI-644694|uniprotkb:E9QKY3|uniprotkb:Q7TMM4|ensembl:ENSMUSP00000098763	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:ylpm1_mouse(display_long)|uniprotkb:Nuclear protein ZAP3(gene name synonym)|uniprotkb:Ylpm1(gene name)|psi-mi:Ylpm1(display_short)|uniprotkb:Zap(gene name synonym)|uniprotkb:Zap3(gene name synonym)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652813	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032204"(regulation of telomere maintenance)|interpro:IPR026314|ensembl:ENSMUSG00000021244(gene)|ensembl:ENSMUST00000101202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|interpro:IPR027417|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|mint:Q9R0I7|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	afcs:33521(primary-reference)|afcs:33546(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1aQLNgVl385Mxmx32eA6x9ccDg10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:0930FD349F201B17|rigid:BG3MWkSAE66txtRy3bSUsFO9jro	false	sufficient binding region:1109-1327	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CRA8	uniprotkb:Q8BTI9	intact:EBI-644704|uniprotkb:Q8K1J2|ensembl:ENSMUSP00000078580|ensembl:ENSMUSP00000145948	intact:EBI-644672|uniprotkb:Q3U4Q1|ensembl:ENSMUSP00000035037	psi-mi:exos5_mouse(display_long)|uniprotkb:Ribosomal RNA-processing protein 46(gene name synonym)|uniprotkb:Exosome component 5(gene name synonym)|uniprotkb:Exosc5(gene name)|psi-mi:Exosc5(display_short)|uniprotkb:D7Wsu180e(gene name synonym)|uniprotkb:Rrp46(gene name synonym)	psi-mi:pk3cb_mouse(display_long)|uniprotkb:Pik3cb(gene name)|psi-mi:Pik3cb(display_short)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652823	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613052.1|reactome:R-MMU-450385|reactome:R-MMU-450513|reactome:R-MMU-450604|reactome:R-MMU-6791226|reactome:R-MMU-429958|ensembl:ENSMUSG00000061286(gene)|ensembl:ENSMUST00000079634(transcript)|ensembl:ENSMUST00000206561(transcript)|go:"GO:0000176"("nuclear exosome (RNase complex)")|go:"GO:0000177"("cytoplasmic exosome (RNase complex)")|go:"GO:0000178"("exosome (RNase complex)")|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006364"(rRNA processing)|go:"GO:0006401"(RNA catabolic process)|go:"GO:0016075"(rRNA catabolic process)|go:"GO:0034427"(nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5')|go:"GO:0034475"(U4 snRNA 3'-end processing)|go:"GO:0035327"|go:"GO:0043928"(exonucleolytic catabolism of deadenylated mRNA)|go:"GO:0045006"(DNA deamination)|go:"GO:0051607"(defense response to virus)|go:"GO:0071028"(nuclear mRNA surveillance)|go:"GO:0071051"(polyadenylation-dependent snoRNA 3'-end processing)|interpro:IPR001247(Exoribonuclease, phosphorolytic domain 1)|interpro:IPR015847(Exoribonuclease, phosphorolytic domain 2)|interpro:IPR020568|interpro:IPR027408|interpro:IPR036345|mint:Q9CRA8	refseq:NP_083370.2|refseq:XP_011241131.1|refseq:XP_011241132.1|ensembl:ENSMUSG00000032462(gene)|ensembl:ENSMUST00000035037(transcript)|go:"GO:0001935"(endothelial cell proliferation)|go:"GO:0001952"(regulation of cell-matrix adhesion)|go:"GO:0002931"(response to ischemia)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0006897"(endocytosis)|go:"GO:0006914"(autophagy)|go:"GO:0007156"(homophilic cell adhesion via plasma membrane adhesion molecules)|go:"GO:0009611"(response to wounding)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0030168"(platelet activation)|go:"GO:0030496"(midbody)|go:"GO:0031526"(brush border membrane)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|go:"GO:0040016"(embryonic cleavage)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0060055"(angiogenesis involved in wound healing)|go:"GO:1900747"(negative regulation of vascular endothelial growth factor signaling pathway)|go:"GO:1903298"(negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway)|go:"GO:1903671"(negative regulation of sprouting angiogenesis)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR037702|interpro:IPR042236|rcsb pdb:2Y3A|rcsb pdb:4BFR|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8853659|reactome:R-MMU-9027276|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-109704|dip:DIP-49395N	afcs:33521(primary-reference)|afcs:40002(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:aLlaVFp6XM+O6L9hOkdqXKo/NwY10090	rogid:DJ0wDyQPs055TTumVtx6c2BqyMU10090	intact-crc:39776E987A74953A|rigid:SX4OAFk/yeTnUIlZep3lax97iQA	false	sufficient binding region:1-235	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54737	uniprotkb:Q60631	intact:EBI-641814	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:o54737_mouse(display_long)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:BCA(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652843	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000980(SH2 motif)|interpro:IPR036860	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:21969(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1zp5CTiuW80CRlnp2JGf/SHMJao10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:8F0901757703A1AB|rigid:uK2NRNrg5y3UIzHcXhB5AA5jYYs	false	sufficient binding region:101-381	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54737	uniprotkb:Q60631	intact:EBI-641814	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:o54737_mouse(display_long)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:BCA(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652853	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000980(SH2 motif)|interpro:IPR036860	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:21969(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1zp5CTiuW80CRlnp2JGf/SHMJao10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:032CD0FA0F0555A2|rigid:uK2NRNrg5y3UIzHcXhB5AA5jYYs	false	sufficient binding region:144-381	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54737	uniprotkb:Q60631	intact:EBI-641814	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:o54737_mouse(display_long)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:BCA(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652863	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000980(SH2 motif)|interpro:IPR036860	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:21969(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1zp5CTiuW80CRlnp2JGf/SHMJao10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:AA4301EB4E57023A|rigid:uK2NRNrg5y3UIzHcXhB5AA5jYYs	false	sufficient binding region:174-300	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PM9	uniprotkb:Q60631	intact:EBI-644712|ensembl:ENSMUSP00000060202	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:uck2_mouse(display_long)|uniprotkb:Uridine monophosphokinase 2(gene name synonym)|uniprotkb:Cytidine monophosphokinase 2(gene name synonym)|uniprotkb:Uck2(gene name)|psi-mi:Uck2(display_short)|uniprotkb:Umpk(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652873	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_109649.1|ensembl:ENSMUSG00000026558(gene)|ensembl:ENSMUST00000053686(transcript)|go:"GO:0004849"(uridine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044206"(UMP salvage)|go:"GO:0044211"(CTP salvage)|interpro:IPR000764(Uridine kinase)|interpro:IPR027417|interpro:IPR029925|reactome:R-MMU-73614|interpro:IPR006083(Phosphoribulokinase/uridine kinase)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:33845(secondary-ac)	-	-	caution:The prey construct contains 64 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:E+lz+mNwgjWmI4Lgx8J9eEuoxRY10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:B864C701D7C8FBA0|rigid:ZVN/v5LoU6t0HgBYcuHYKrHjS8Q	false	sufficient binding region:1-261	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PM9	uniprotkb:Q60631	intact:EBI-644712|ensembl:ENSMUSP00000060202	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:uck2_mouse(display_long)|uniprotkb:Uridine monophosphokinase 2(gene name synonym)|uniprotkb:Cytidine monophosphokinase 2(gene name synonym)|uniprotkb:Uck2(gene name)|psi-mi:Uck2(display_short)|uniprotkb:Umpk(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652884	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_109649.1|ensembl:ENSMUSG00000026558(gene)|ensembl:ENSMUST00000053686(transcript)|go:"GO:0004849"(uridine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044206"(UMP salvage)|go:"GO:0044211"(CTP salvage)|interpro:IPR000764(Uridine kinase)|interpro:IPR027417|interpro:IPR029925|reactome:R-MMU-73614|interpro:IPR006083(Phosphoribulokinase/uridine kinase)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:33845(secondary-ac)	-	-	caution:The prey construct contains 55 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:E+lz+mNwgjWmI4Lgx8J9eEuoxRY10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:33D240462BED2654|rigid:ZVN/v5LoU6t0HgBYcuHYKrHjS8Q	false	sufficient binding region:1-237	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PM9	uniprotkb:Q60631	intact:EBI-644712|ensembl:ENSMUSP00000060202	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:uck2_mouse(display_long)|uniprotkb:Uridine monophosphokinase 2(gene name synonym)|uniprotkb:Cytidine monophosphokinase 2(gene name synonym)|uniprotkb:Uck2(gene name)|psi-mi:Uck2(display_short)|uniprotkb:Umpk(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652895	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_109649.1|ensembl:ENSMUSG00000026558(gene)|ensembl:ENSMUST00000053686(transcript)|go:"GO:0004849"(uridine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044206"(UMP salvage)|go:"GO:0044211"(CTP salvage)|interpro:IPR000764(Uridine kinase)|interpro:IPR027417|interpro:IPR029925|reactome:R-MMU-73614|interpro:IPR006083(Phosphoribulokinase/uridine kinase)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:33845(secondary-ac)	-	-	caution:The prey construct contains 55 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:E+lz+mNwgjWmI4Lgx8J9eEuoxRY10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:81421DA9A2F653EF|rigid:ZVN/v5LoU6t0HgBYcuHYKrHjS8Q	false	sufficient binding region:1-261	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91ZZ2	uniprotkb:Q60631	intact:EBI-644719|ensembl:ENSMUSP00000099936	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:q91zz2_mouse(display_long)|uniprotkb:Rapgef1(gene name)|psi-mi:Rapgef1(display_short)|uniprotkb:Grf2(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652905	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_473391.1|ensembl:ENSMUSG00000039844(gene)|ensembl:ENSMUST00000102872(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR019804|interpro:IPR023578|interpro:IPR036964	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:23826(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:heLCxkFCi/GUrFw2EdEUUd7yQS010090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:827EEE13FCBD3632|rigid:fFwhd5oSDLo7MeYL9u35oyqTw2s	false	sufficient binding region:195-592	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91ZZ2	uniprotkb:Q60631	intact:EBI-644719|ensembl:ENSMUSP00000099936	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:q91zz2_mouse(display_long)|uniprotkb:Rapgef1(gene name)|psi-mi:Rapgef1(display_short)|uniprotkb:Grf2(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652925	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_473391.1|ensembl:ENSMUSG00000039844(gene)|ensembl:ENSMUST00000102872(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR019804|interpro:IPR023578|interpro:IPR036964	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:23826(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:heLCxkFCi/GUrFw2EdEUUd7yQS010090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:3DC73E782356DC1E|rigid:fFwhd5oSDLo7MeYL9u35oyqTw2s	false	sufficient binding region:438-626	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EQ32	uniprotkb:Q60631	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652935	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:30681(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:9AAB8806D97B4A59|rigid:gXsGEgo1N78SJnS1c/b147OqqoE	false	sufficient binding region:424-811	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EQ32	uniprotkb:Q60631	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652945	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:30681(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:1A396703D98E7B77|rigid:gXsGEgo1N78SJnS1c/b147OqqoE	false	sufficient binding region:471-811	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06151	uniprotkb:Q9JHG7	intact:EBI-444940|ensembl:ENSMUSP00000036386|ensembl:ENSMUSP00000103267	intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400	psi-mi:ldha_mouse(display_long)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Ldha(gene name)|psi-mi:Ldha(display_short)|uniprotkb:Ldh-1(gene name synonym)|uniprotkb:Ldh1(gene name synonym)	psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652096	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034829.1|ensembl:ENSMUSG00000063229(gene)|ensembl:ENSMUST00000005051(transcript)|ensembl:ENSMUST00000048209(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019661"(glucose catabolic process to lactate via pyruvate)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P06151|reactome:R-MMU-70268	refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N	afcs:18478(primary-reference)|afcs:16317(secondary-ac)	-	-	caution:The prey construct contains 8 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:IErFuOIWq53/XyIxWgUyVi76VnM10090	rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090	intact-crc:F6153AADEE1FBC07|rigid:PhTerrJ51JP2+hz239rxjZnfHvE	false	sufficient binding region:2-332	sufficient binding region:1-200	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BKC5	uniprotkb:P70315	intact:EBI-643605|uniprotkb:Q3TEG2|uniprotkb:Q7TQC6|uniprotkb:Q9EQ30|ensembl:ENSMUSP00000032898	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:ipo5_mouse(display_long)|uniprotkb:Ranbp5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)|uniprotkb:Ipo5(gene name)|psi-mi:Ipo5(display_short)|uniprotkb:Kpnb3(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652157	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076068.1|refseq:XP_006519603.1|ensembl:ENSMUSG00000030662(gene)|ensembl:ENSMUST00000032898(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:Q8BKC5|go:"GO:0006607"(NLS-bearing protein import into nucleus)	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:20927(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZtMfEhsr1lfJDBglaNlc7j4GHZ010090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:330CC1E051D15339|rigid:cMIi1q2ZNGRABeCDJY1zPoYG7sE	false	sufficient binding region:692-1003	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BKC5	uniprotkb:P70315	intact:EBI-643605|uniprotkb:Q3TEG2|uniprotkb:Q7TQC6|uniprotkb:Q9EQ30|ensembl:ENSMUSP00000032898	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:ipo5_mouse(display_long)|uniprotkb:Ranbp5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)|uniprotkb:Ipo5(gene name)|psi-mi:Ipo5(display_short)|uniprotkb:Kpnb3(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652187	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076068.1|refseq:XP_006519603.1|ensembl:ENSMUSG00000030662(gene)|ensembl:ENSMUST00000032898(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:Q8BKC5|go:"GO:0006607"(NLS-bearing protein import into nucleus)	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:20927(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZtMfEhsr1lfJDBglaNlc7j4GHZ010090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:49177FB9F277E482|rigid:cMIi1q2ZNGRABeCDJY1zPoYG7sE	false	sufficient binding region:639-1056	sufficient binding region:1-231	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DBY1	uniprotkb:P70315	intact:EBI-644384|uniprotkb:Q80T88|uniprotkb:Q8CGB5	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:syvn1_mouse(display_long)|uniprotkb:Synovial apoptosis inhibitor 1(gene name synonym)|uniprotkb:Syvn1(gene name)|psi-mi:Syvn1(display_short)|uniprotkb:Hrd1(gene name synonym)|uniprotkb:Kiaa1810(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase synoviolin(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652198	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000839"(Hrd1p ubiquitin ligase ERAD-L complex)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002327"(immature B cell differentiation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006986"(response to unfolded protein)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0036503"(ERAD pathway)|refseq:NP_001158181.1|refseq:NP_083045.4|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR032832|refseq:XP_006531913.1|go:"GO:1902236"(negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|mint:Q9DBY1	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:35820(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sNJ5FrwHnnTl0Muz1OYFROcxgrg10090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:9D99523B9AC37595|rigid:TtDDGFyMiRw+tEvVEjYSiXRXZWg	false	sufficient binding region:375-549	sufficient binding region:1-231	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35991	uniprotkb:Q60631	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652219	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:17216(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:9AC53BA29219E2EF|rigid:KpeZ6uMd5MDk4wkGJvyIgL4gVIg	false	sufficient binding region:142-271	sufficient binding region:1-70	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35991	uniprotkb:Q60631	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652229	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:17216(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:E8E3A1B83A495969|rigid:KpeZ6uMd5MDk4wkGJvyIgL4gVIg	false	sufficient binding region:164-392	sufficient binding region:1-70	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35991	uniprotkb:Q60631	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652239	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:17216(secondary-ac)|afcs:53767(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:5C7CFB7C3D348803|rigid:KpeZ6uMd5MDk4wkGJvyIgL4gVIg	false	sufficient binding region:175-383	sufficient binding region:1-70	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88643	uniprotkb:P60766-2	intact:EBI-457240	intact:EBI-287404|uniprotkb:P21181-4|ensembl:ENSMUSP00000054634	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:p60766-2(display_long)|uniprotkb:Cdc42(gene name)|psi-mi:Cdc42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)|uniprotkb:Placental(isoform synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651243	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	intact:EBI-81763(cdc42_mouse)|ensembl:ENSMUSG00000006699(gene)|ensembl:ENSMUST00000051477(transcript)	afcs:15804(primary-reference)|afcs:16524(secondary-ac)	-	isoform-comment:Has not been isolated in bovine so far	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU10090	intact-crc:D7FD8BFE97CFAAFC|rigid:8SLvWv2a/VFyNy05uzjvnAd76Qo	false	sufficient binding region:65-258	sufficient binding region:1-190	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIF7	uniprotkb:E9Q401	intact:EBI-643655|uniprotkb:Q3T9Y4|uniprotkb:Q3TT72|uniprotkb:Q3U8G9|uniprotkb:Q3UE02|ensembl:ENSMUSP00000033012	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	psi-mi:copb_mouse(display_long)|uniprotkb:Beta-coat protein(gene name synonym)|uniprotkb:Copb1(gene name)|psi-mi:Copb1(display_short)|uniprotkb:Copb(gene name synonym)	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651341	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_203534.1|ensembl:ENSMUSG00000030754(gene)|ensembl:ENSMUST00000033012(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:Q9JIF7|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811434|dip:DIP-42642N	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	afcs:24653(primary-reference)|afcs:30821(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:iDZBrOVDDEDKOg968HyvA3hXWF810090	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	intact-crc:5EEA12601D99F0D9|rigid:Bw0EbSBQaOCABr16VLMW2flnNlc	false	sufficient binding region:649-953	sufficient binding region:625-901	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TMK6	uniprotkb:O08908	intact:EBI-643708|uniprotkb:Q8BY47|uniprotkb:Q8R347|uniprotkb:Q8VCN4|uniprotkb:Q99LU2|uniprotkb:Q66JV2|ensembl:ENSMUSP00000067752	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:hook2_mouse(display_long)|uniprotkb:Hook2(gene name)|psi-mi:Hook2(display_short)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651382	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001161463.1|refseq:NP_573518.2|ensembl:ENSMUSG00000052566(gene)|ensembl:ENSMUST00000064495(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0007032"(endosome organization)|go:"GO:0007040"(lysosome organization)|go:"GO:0008017"(microtubule binding)|go:"GO:0008333"(endosome to lysosome transport)|go:"GO:0015031"(protein transport)|go:"GO:0030705"(cytoskeleton-dependent intracellular transport)|go:"GO:0030897"(HOPS complex)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0070695"(FHF complex)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR008636(HOOK)|interpro:IPR036872|interpro:IPR043936|go:"GO:0045022"(early endosome to late endosome transport)	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:35155(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ukTs0PuUe15+QA0bb7roixj3OS010090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:5AD1B95E6DF89DB4|rigid:BrJI5GfjYiRgnP38FiN0Bx+yZIk	false	sufficient binding region:113-506	sufficient binding region:497-722	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97801	uniprotkb:Q60992	intact:EBI-309807|uniprotkb:O09092|ensembl:ENSMUSP00000022147	intact:EBI-643726|uniprotkb:A2AH49|ensembl:ENSMUSP00000062782	psi-mi:smn_mouse(display_long)|uniprotkb:Smn1(gene name)|psi-mi:Smn1(display_short)|uniprotkb:Smn(gene name synonym)	psi-mi:vav2_mouse(display_long)|uniprotkb:Vav2(gene name)|psi-mi:Vav2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651413	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001239558.1|refseq:NP_035550.1|ensembl:ENSMUSG00000021645(gene)|ensembl:ENSMUST00000022147(transcript)|go:"GO:0000387"(spliceosomal snRNP assembly)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006353"(DNA-templated transcription, termination)|go:"GO:0007019"(microtubule depolymerization)|go:"GO:0007409"(axonogenesis)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0015030"(Cajal body)|go:"GO:0016604"(nuclear body)|go:"GO:0017134"(fibroblast growth factor binding)|go:"GO:0030018"(Z disc)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030426"(growth cone)|go:"GO:0032797"(SMN complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034719"(SMN-Sm protein complex)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0097504"(Gemini of coiled bodies)|interpro:IPR002999(Tudor)|interpro:IPR010304(Survival motor neuron)|mint:P97801|reactome:R-MMU-191859	refseq:NP_033526.1|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:Q60992|reactome:R-MMU-114604|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-3928665|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-445144|reactome:R-MMU-5218920|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|interpro:IPR000980(SH2 motif)|ensembl:ENSMUSG00000009621(gene)|ensembl:ENSMUST00000056176(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")	afcs:15546(primary-reference)|afcs:12579(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:cTFjZc/daUP5J6lWPrCVM5ZsGeU10090	rogid:PYI5dXgxDpwXCc7HMwQFN4H15Zs10090	intact-crc:9C4341E084F86D0F|rigid:U2qcw3R6mNWA3lX7YTP5sGdYDC8	false	sufficient binding region:122-288	sufficient binding region:760-868	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ERU9	uniprotkb:Q62077	intact:EBI-643756|uniprotkb:E9QM01|uniprotkb:Q61992|uniprotkb:Q8C9K9|ensembl:ENSMUSP00000003310	intact:EBI-300133|ensembl:ENSMUSP00000099404|uniprotkb:Q6P1G1	psi-mi:rbp2_mouse(display_long)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Ranbp2(gene name)|psi-mi:Ranbp2(display_short)	psi-mi:plcg1_mouse(display_long)|uniprotkb:Plcg1(gene name)|psi-mi:Plcg1(display_short)|uniprotkb:Plcg-1(gene name synonym)|uniprotkb:Phosphoinositide phospholipase C-gamma-1(gene name synonym)|uniprotkb:Phospholipase C-gamma-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651424	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035370.2|reactome:R-MMU-191859|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000003226(gene)|ensembl:ENSMUST00000003310(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:Q9ERU9|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822	ensembl:ENSMUSG00000016933(gene)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0009306"(protein secretion)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016477"(cell migration)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0042995"(cell projection)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046488"(phosphatidylinositol metabolic process)|ensembl:ENSMUST00000103115(transcript)|go:"GO:0050429"(calcium-dependent phospholipase C activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001726"(ruffle)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901339"(regulation of store-operated calcium channel activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:2000353"(positive regulation of endothelial cell apoptotic process)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR018247|interpro:IPR028380|interpro:IPR035023|interpro:IPR035024|interpro:IPR001849(Pleckstrin-like)|interpro:IPR035724|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q62077|reactome:R-MMU-1169408|interpro:IPR011992(EF-Hand type)|reactome:R-MMU-1855204|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-210990|reactome:R-MMU-212718|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5218921|reactome:R-MMU-5654219|reactome:R-MMU-5654221|reactome:R-MMU-5654227|reactome:R-MMU-5654228|reactome:R-MMU-8853659|reactome:R-MMU-9026527|reactome:R-MMU-9034793|refseq:NP_067255.2|dip:DIP-29284N	afcs:33522(primary-reference)|afcs:35179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:cjIAIF0uuxSMRXErJiJc+OBJpAw10090	rogid:XI8Kf6uWLwa8rJL5W1r6BeGK7lc10090	intact-crc:1436BE131FD8328E|rigid:B1VlIEcMTznExAUEN0qakkF4lmo	false	sufficient binding region:1273-1902	sufficient binding region:542-753	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:B9EKI5	uniprotkb:Q60992	intact:EBI-682463|ensembl:ENSMUSP00000110115|ensembl:ENSMUSP00000154583	intact:EBI-643726|uniprotkb:A2AH49|ensembl:ENSMUSP00000062782	psi-mi:b9eki5_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)	psi-mi:vav2_mouse(display_long)|uniprotkb:Vav2(gene name)|psi-mi:Vav2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688268	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028410.1|refseq:XP_006522014.1|ensembl:ENSMUSG00000022637(gene)|ensembl:ENSMUST00000114471(transcript)|ensembl:ENSMUST00000227062(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023051"(regulation of signaling)|go:"GO:0047690"(aspartyltransferase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520	refseq:NP_033526.1|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR035732|interpro:IPR035733|interpro:IPR035880|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:Q60992|reactome:R-MMU-114604|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-3928665|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-445144|reactome:R-MMU-5218920|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9013423|interpro:IPR000980(SH2 motif)|ensembl:ENSMUSG00000009621(gene)|ensembl:ENSMUST00000056176(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0016477"(cell migration)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0046872"(metal ion binding)|interpro:IPR000219("Dbl homology (DH) domain")	afcs:20358(secondary-ac)|afcs:15546(primary-reference)|afcs:20358(primary-reference)	comment:"AfCS Y2H protein 20358. Sequence deduced from cross-reference: protein GI: 20894431, replaced by protein GI: 51769670."|comment:"similat to rat Casitas B-lineage lymphoma b; Cbl-b protein (98%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/a/ZrHmGa1+dJMyubsxdzGfCrdQ10090	rogid:PYI5dXgxDpwXCc7HMwQFN4H15Zs10090	intact-crc:F2713737D84871B2|rigid:YLDS1LXFpkr/mtc4Z6K0h4+kZGE	false	sufficient binding region:332-486	sufficient binding region:760-868	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q922Q8	uniprotkb:P22366	intact:EBI-647863|uniprotkb:Q3TJ35|uniprotkb:Q3TLC7|uniprotkb:Q3TWT9|uniprotkb:Q3TX86|ensembl:ENSMUSP00000021239	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:lrc59_mouse(display_long)|uniprotkb:Lrrc59(gene name)|psi-mi:Lrrc59(display_short)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658942	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598568.1|ensembl:ENSMUSG00000020869(gene)|ensembl:ENSMUST00000021239(transcript)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0042645"(mitochondrial nucleoid)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR032675|mint:Q922Q8	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	afcs:10042(primary-reference)|afcs:58480(secondary-ac)	-	-	caution:The prey construct contains 39 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Y2nzjMFwQhLMP697NokEz+jOLUM10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:3AF9F9387FEFBEB8|rigid:eVNgFd3W39C8Eb05GXbG6LK54xc	false	sufficient binding region:1-155	sufficient binding region:1-141	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BL66	uniprotkb:Q62406-1	intact:EBI-647872|uniprotkb:Q6DIC2|ensembl:ENSMUSP00000061493	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:eea1_mouse(display_long)|uniprotkb:Eea1(gene name)|psi-mi:Eea1(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658952	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001001932.1|ensembl:ENSMUSG00000036499(gene)|ensembl:ENSMUST00000053484(transcript)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005969"(serine-pyruvate aminotransferase complex)|go:"GO:0006897"(endocytosis)|go:"GO:0006906"(vesicle fusion)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044308"(axonal spine)|go:"GO:0046872"(metal ion binding)|go:"GO:0055037"(recycling endosome)|interpro:IPR000306(Zinc finger, FYVE-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR017455(Zinc finger, FYVE-related)|mint:Q8BL66|reactome:R-MMU-168138	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:58481(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FqV4Df8McEI65bJvu1Bxd3uqqPk10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:C6E0A07E47A330EB|rigid:N27P1jdwuhiAT4gYHQg7n2ZRl/o	false	sufficient binding region:?-?	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:B0V2N1	uniprotkb:Q60680-1	intact:EBI-647877|uniprotkb:Q3TEC3|uniprotkb:Q3TXC9|uniprotkb:Q5XJV4|uniprotkb:Q64503|uniprotkb:Q64699|uniprotkb:Q7TT17|uniprotkb:Q4JFC7|ensembl:ENSMUSP00000064048	intact:EBI-646260	psi-mi:ptprs_mouse(display_long)|uniprotkb:Ptprs(gene name)|psi-mi:Ptprs(display_short)|uniprotkb:Receptor-type tyrosine-protein phosphatase sigma(gene name synonym)|uniprotkb:PTPNU-3(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658962	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035348.2|refseq:NP_001239382.1|refseq:NP_001239384.1|refseq:NP_001239385.1|go:"GO:0021549"(cerebellum development)|go:"GO:0021766"(hippocampus development)|go:"GO:0021987"(cerebral cortex development)|go:"GO:0022038"(corpus callosum development)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0032687"(negative regulation of interferon-alpha production)|go:"GO:0032688"(negative regulation of interferon-beta production)|go:"GO:0034164"(negative regulation of toll-like receptor 9 signaling pathway)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035374"(chondroitin sulfate binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043395"(heparan sulfate proteoglycan binding)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0048681"(negative regulation of axon regeneration)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050808"(synapse organization)|go:"GO:0061000"(negative regulation of dendritic spine development)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099061"(integral component of postsynaptic density membrane)|go:"GO:0099151"(regulation of postsynaptic density assembly)|go:"GO:0099560"(synaptic membrane adhesion)|go:"GO:1905606"(regulation of presynapse assembly)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036116|interpro:IPR036179|mint:B0V2N1|rcsb pdb:3SR9|reactome:R-MMU-388844|reactome:R-MMU-8849932|ensembl:ENSMUSG00000013236(gene)|ensembl:ENSMUST00000067538(transcript)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0008201"(heparin binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0021510"(spinal cord development)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:58483(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZHccWWvEOOQcSSD7ic6ow6xeqtU10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:B89E2F4A9BF8D085|rigid:PImAjIBSott83wB+bCcpc7xUab0	false	sufficient binding region:365-660	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:B2RR24	uniprotkb:Q6PDN3	intact:EBI-687261|ensembl:ENSMUSP00000130004	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:b2rr24_mouse(display_long)|uniprotkb:Zfp236(gene name)|psi-mi:Zfp236(display_short)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808500.2|ensembl:ENSMUSG00000041258(gene)|ensembl:ENSMUST00000171071(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0071333"(cellular response to glucose stimulus)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:58482(secondary-ac)|afcs:35660(primary-reference)	caution:"Protein [uniprotkb:B2RR24] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"	-	caution:"Protein [uniprotkb:B2RR24] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:37DueTqJ4c8Rgc7PBEzRuPZxNPA10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:DB3BA8AF68D070CC|rigid:grYy4IhSafbsXNqaD6W8OATT8Ns	false	sufficient binding region:?-?	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:P11798-2	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652651	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:12352(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:45B0AB823E302566|rigid:WhmWQx23bI3f9y+vnPgl8+fW2FY	false	sufficient binding region:243-525	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54737	uniprotkb:Q60631	intact:EBI-641814	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:o54737_mouse(display_long)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:BCA(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652833	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000980(SH2 motif)|interpro:IPR036860	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:21969(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1zp5CTiuW80CRlnp2JGf/SHMJao10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:5D4A3FFD619022EC|rigid:uK2NRNrg5y3UIzHcXhB5AA5jYYs	false	sufficient binding region:80-262	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91ZZ2	uniprotkb:Q60631	intact:EBI-644719|ensembl:ENSMUSP00000099936	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:q91zz2_mouse(display_long)|uniprotkb:Rapgef1(gene name)|psi-mi:Rapgef1(display_short)|uniprotkb:Grf2(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652915	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_473391.1|ensembl:ENSMUSG00000039844(gene)|ensembl:ENSMUST00000102872(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032486"(Rap protein signal transduction)|go:"GO:0032991"(protein-containing complex)|go:"GO:0038180"(nerve growth factor signaling pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046580"(negative regulation of Ras protein signal transduction)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1901888"(regulation of cell junction assembly)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:1990090"(cellular response to nerve growth factor stimulus)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR019804|interpro:IPR023578|interpro:IPR036964	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:23826(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:heLCxkFCi/GUrFw2EdEUUd7yQS010090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:429B0D06901262CC|rigid:fFwhd5oSDLo7MeYL9u35oyqTw2s	false	sufficient binding region:427-592	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:Q60631	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653020	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:12352(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:59427EA40160BEE8|rigid:IMpb5Puw47unMafVDFjLucTSJnw	false	sufficient binding region:624-856	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EQ32	uniprotkb:Q9EQ32	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653030	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	afcs:30681(primary-reference)|afcs:30681(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	intact-crc:B0C718B5F192F3DD|rigid:sqk6O3oLyfcdGVdp7fDxJlBBqoo	false	sufficient binding region:115-429	sufficient binding region:150-400	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EQ32	uniprotkb:Q9EQ32	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653041	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	afcs:30681(primary-reference)|afcs:30681(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	intact-crc:1A69D80DC5976175|rigid:sqk6O3oLyfcdGVdp7fDxJlBBqoo	false	sufficient binding region:159-679	sufficient binding region:150-400	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EQ32	uniprotkb:Q9EQ32	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653051	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	afcs:30681(primary-reference)|afcs:30681(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	intact-crc:E2D6A35D8EE4888F|rigid:sqk6O3oLyfcdGVdp7fDxJlBBqoo	false	sufficient binding region:178-380	sufficient binding region:150-400	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P39054-2	uniprotkb:Q60631	intact:EBI-642353|ensembl:ENSMUSP00000088616	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:p39054-2(display_long)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym)|uniprotkb:Dynamin UDNM(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653061	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-642337(dyn2_mouse)|ensembl:ENSMUSG00000033335(gene)|ensembl:ENSMUST00000091087(transcript)	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:14203(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:erJ4QqPwOjhyjX7e5ST4NEus3lo10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:55D627C2A6F68D1D|rigid:Ps7eolqrNDGAgkHjQDdlqCfN1KE	false	sufficient binding region:621-866	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64345	uniprotkb:P11798-2	intact:EBI-644819|uniprotkb:Q99L62|ensembl:ENSMUSP00000099889	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:ifit3_mouse(display_long)|uniprotkb:Glucocorticoid-attenuated response gene 49 protein(gene name synonym)|uniprotkb:IRG2(gene name synonym)|uniprotkb:Ifit3(gene name)|psi-mi:Ifit3(display_short)|uniprotkb:Garg49(gene name synonym)|uniprotkb:Ifi49(gene name synonym)|uniprotkb:Isg49(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653182	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034631.1|ensembl:ENSMUSG00000074896(gene)|ensembl:ENSMUST00000102825(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009615"(response to virus)|go:"GO:0009617"(response to bacterium)|go:"GO:0035457"(cellular response to interferon-alpha)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0035634"(response to stilbenoid)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045087"(innate immune response)|go:"GO:0051607"(defense response to virus)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR024122	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:16213(secondary-ac)	-	isoform-comment:Has no kinase activity.	caution:The prey construct contains 9 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:OjoF7slFjr0nHUw1i2WS1a2i70810090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:8B4A68020D39938A|rigid:rmhJqrQ/fe82zwlMBtGyR891hOs	false	sufficient binding region:1-304	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02384	uniprotkb:Q60631	intact:EBI-395573|ensembl:ENSMUSP00000138793	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:sos2_mouse(display_long)|uniprotkb:Sos2(gene name)|psi-mi:Sos2(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653232	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034801(gene)|ensembl:ENSMUST00000183277(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|rcsb pdb:1GBR|reactome:R-MMU-416482|reactome:R-MMU-193648|refseq:XP_006515698.1|reactome:R-MMU-8983432|reactome:R-MMU-9013149	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:33836(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:s2OD+2IxmqGbJeKCshNho0MJczM10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:C57A6E2CC457612A|rigid:EzXl9RSWNqHJflfY/7eI1Sh5odU	false	sufficient binding region:963-1271	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R550	uniprotkb:Q60631	intact:EBI-642709|uniprotkb:Q8CAL8|uniprotkb:Q8CEF6|uniprotkb:Q8R545|uniprotkb:Q8R546|uniprotkb:Q8R547|uniprotkb:Q8R548|uniprotkb:Q8R549|uniprotkb:Q8R551|uniprotkb:Q9CTQ9|uniprotkb:Q9DC14|uniprotkb:Q9JKC3|uniprotkb:B1AZ86|uniprotkb:B1AZ87|ensembl:ENSMUSP00000072840	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:sh3k1_mouse(display_long)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653272	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129199.1|refseq:NP_001129200.1|refseq:NP_067364.2|refseq:XP_006528987.1|ensembl:ENSMUSG00000040990(gene)|ensembl:ENSMUST00000073094(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q8R550|rcsb pdb:1WI7|rcsb pdb:2DA9|rcsb pdb:5XHZ|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866376|reactome:R-MMU-983695|refseq:XP_011246151.1|refseq:XP_011246153.1|refseq:NP_001277590.1|refseq:NP_001277593.1	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:23893(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Fd7WikE+fZIgob7Ax2vr9J291N010090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:4F7929DD188E61E3|rigid:DuRg0Sh/4iQMEmYlxu3YGx+cnAw	false	sufficient binding region:534-709	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:B9EKI5	uniprotkb:Q60631	intact:EBI-682463|ensembl:ENSMUSP00000110115|ensembl:ENSMUSP00000154583	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:b9eki5_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688312	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028410.1|refseq:XP_006522014.1|ensembl:ENSMUSG00000022637(gene)|ensembl:ENSMUST00000114471(transcript)|ensembl:ENSMUST00000227062(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023051"(regulation of signaling)|go:"GO:0047690"(aspartyltransferase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:20358(primary-reference)|afcs:20358(secondary-ac)	comment:"AfCS Y2H protein 20358. Sequence deduced from cross-reference: protein GI: 20894431, replaced by protein GI: 51769670."|comment:"similat to rat Casitas B-lineage lymphoma b; Cbl-b protein (98%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/a/ZrHmGa1+dJMyubsxdzGfCrdQ10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:CE57BFF4F44CE8C7|rigid:ZKP7/Askv0dep7OrB42aPBnZBXI	false	sufficient binding region:18-186	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:B9EKI5	uniprotkb:Q60631	intact:EBI-682463|ensembl:ENSMUSP00000110115|ensembl:ENSMUSP00000154583	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:b9eki5_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688325	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028410.1|refseq:XP_006522014.1|ensembl:ENSMUSG00000022637(gene)|ensembl:ENSMUST00000114471(transcript)|ensembl:ENSMUST00000227062(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023051"(regulation of signaling)|go:"GO:0047690"(aspartyltransferase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:20358(secondary-ac)|afcs:53767(primary-reference)|afcs:20358(primary-reference)	comment:"AfCS Y2H protein 20358. Sequence deduced from cross-reference: protein GI: 20894431, replaced by protein GI: 51769670."|comment:"similat to rat Casitas B-lineage lymphoma b; Cbl-b protein (98%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/a/ZrHmGa1+dJMyubsxdzGfCrdQ10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:B257490C33167492|rigid:ZKP7/Askv0dep7OrB42aPBnZBXI	false	sufficient binding region:306-486	sufficient binding region:1-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P06151	uniprotkb:Q9JHG7	intact:EBI-444940|ensembl:ENSMUSP00000036386|ensembl:ENSMUSP00000103267	intact:EBI-644372|uniprotkb:Q80V09|ensembl:ENSMUSP00000062864|ensembl:ENSMUSP00000082596|ensembl:ENSMUSP00000123539|ensembl:ENSMUSP00000151400	psi-mi:ldha_mouse(display_long)|uniprotkb:LDH muscle subunit(gene name synonym)|uniprotkb:Ldha(gene name)|psi-mi:Ldha(display_short)|uniprotkb:Ldh-1(gene name synonym)|uniprotkb:Ldh1(gene name synonym)	psi-mi:pk3cg_mouse(display_long)|uniprotkb:p120-PI3K(gene name synonym)|uniprotkb:Pik3cg(gene name)|psi-mi:Pik3cg(display_short)|uniprotkb:Pi3kg1(gene name synonym)|uniprotkb:Phosphoinositide-3-kinase catalytic gamma polypeptide(gene name synonym)|uniprotkb:Serine/threonine protein kinase PIK3CG(gene name synonym)|uniprotkb:Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652107	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034829.1|ensembl:ENSMUSG00000063229(gene)|ensembl:ENSMUST00000005051(transcript)|ensembl:ENSMUST00000048209(transcript)|go:"GO:0004457"(lactate dehydrogenase activity)|go:"GO:0004459"(L-lactate dehydrogenase activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0019244"(lactate biosynthetic process from pyruvate)|go:"GO:0019661"(glucose catabolic process to lactate via pyruvate)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|interpro:IPR001236(Lactate/malate dehydrogenase)|interpro:IPR001557(L-lactate/malate dehydrogenase)|interpro:IPR011304(L-lactate dehydrogenase)|interpro:IPR015955(Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal)|interpro:IPR018177|interpro:IPR022383|interpro:IPR036291|mint:P06151|reactome:R-MMU-70268	refseq:NP_001139672.1|refseq:NP_001139673.1|refseq:NP_064668.2|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0046934"(phosphatidylinositol-4,5-bisphosphate 3-kinase activity)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0052742"(phosphatidylinositol kinase activity)|go:"GO:0052812"(phosphatidylinositol-3,4-bisphosphate 5-kinase activity)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0097284"(hepatocyte apoptotic process)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903169"(regulation of calcium ion transmembrane transport)|go:"GO:2000270"(negative regulation of fibroblast apoptotic process)|interpro:IPR000341(Phosphoinositide 3-kinase, ras-binding)|interpro:IPR000403(Phosphatidylinositol 3- and 4-kinase, catalytic)|interpro:IPR001263(Phosphoinositide 3-kinase accessory region PIK)|interpro:IPR002420(Phosphoinositide 3-kinase, C2)|ensembl:ENSMUSG00000020573(gene)|ensembl:ENSMUST00000053215(transcript)|ensembl:ENSMUST00000085469(transcript)|ensembl:ENSMUST00000156904(transcript)|ensembl:ENSMUST00000220366(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002675"(positive regulation of acute inflammatory response)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0005944"(phosphatidylinositol 3-kinase complex, class IB)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006897"(endocytosis)|go:"GO:0006935"(chemotaxis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010897"(negative regulation of triglyceride catabolic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016301"(kinase activity)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0016310"(phosphorylation)|go:"GO:0016477"(cell migration)|go:"GO:0032252"(secretory granule localization)|go:"GO:0035005"(1-phosphatidylinositol-4-phosphate 3-kinase activity)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015433(Phosphatidylinositol Kinase)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR018936|interpro:IPR029071|interpro:IPR035892|interpro:IPR036940|interpro:IPR042236|reactome:R-MMU-114604|reactome:R-MMU-1660499|reactome:R-MMU-392451|reactome:R-MMU-9027276|interpro:IPR003113(Phosphatidylinositol 3-kinase, p85-binding)|refseq:XP_006515175.1|go:"GO:0036092"(phosphatidylinositol-3-phosphate biosynthetic process)|dip:DIP-41862N	afcs:18478(primary-reference)|afcs:16317(secondary-ac)	-	-	caution:The prey construct contains 8 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:IErFuOIWq53/XyIxWgUyVi76VnM10090	rogid:SV/AI6H65Utm5ENkfXkXQ4lqaao10090	intact-crc:655A4EDDF3AE2F7E|rigid:PhTerrJ51JP2+hz239rxjZnfHvE	false	sufficient binding region:2-332	sufficient binding region:1-200	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01768	uniprotkb:P09055	intact:EBI-642573|ensembl:ENSMUSP00000021217|ensembl:ENSMUSP00000103476	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:ndkb_mouse(display_long)|uniprotkb:nm23-M2(gene name synonym)|uniprotkb:P18(gene name synonym)|uniprotkb:Nme2(gene name)|psi-mi:Nme2(display_short)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651861	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070997.1|refseq:NP_032731.1|ensembl:ENSMUSG00000020857(gene)|ensembl:ENSMUST00000021217(transcript)|ensembl:ENSMUST00000072566(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1901363"(heterocyclic compound binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q01768|reactome:R-MMU-499943|reactome:R-MMU-6798695	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:7069(secondary-ac)|afcs:18892(primary-reference)	-	-	caution:The prey construct contains 5 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AJ1Depmyy9zwTEUOZMRO7TKPd1k10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:46DB1E62EAE10BB7|rigid:F9EmQdXxnmQWKy4XeMPJRepbQNY	false	sufficient binding region:1-152	sufficient binding region:350-602	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BKC5	uniprotkb:P70315	intact:EBI-643605|uniprotkb:Q3TEG2|uniprotkb:Q7TQC6|uniprotkb:Q9EQ30|ensembl:ENSMUSP00000032898	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:ipo5_mouse(display_long)|uniprotkb:Ranbp5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)|uniprotkb:Ipo5(gene name)|psi-mi:Ipo5(display_short)|uniprotkb:Kpnb3(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652116	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076068.1|refseq:XP_006519603.1|ensembl:ENSMUSG00000030662(gene)|ensembl:ENSMUST00000032898(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:Q8BKC5|go:"GO:0006607"(NLS-bearing protein import into nucleus)	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:20927(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZtMfEhsr1lfJDBglaNlc7j4GHZ010090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:94E58FBA7FAAC9BB|rigid:cMIi1q2ZNGRABeCDJY1zPoYG7sE	false	sufficient binding region:641-1030	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BKC5	uniprotkb:P70315	intact:EBI-643605|uniprotkb:Q3TEG2|uniprotkb:Q7TQC6|uniprotkb:Q9EQ30|ensembl:ENSMUSP00000032898	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:ipo5_mouse(display_long)|uniprotkb:Ranbp5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)|uniprotkb:Ipo5(gene name)|psi-mi:Ipo5(display_short)|uniprotkb:Kpnb3(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076068.1|refseq:XP_006519603.1|ensembl:ENSMUSG00000030662(gene)|ensembl:ENSMUST00000032898(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:Q8BKC5|go:"GO:0006607"(NLS-bearing protein import into nucleus)	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:20927(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZtMfEhsr1lfJDBglaNlc7j4GHZ010090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:134DDE3129EE997D|rigid:cMIi1q2ZNGRABeCDJY1zPoYG7sE	false	sufficient binding region:642-817	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BKC5	uniprotkb:P70315	intact:EBI-643605|uniprotkb:Q3TEG2|uniprotkb:Q7TQC6|uniprotkb:Q9EQ30|ensembl:ENSMUSP00000032898	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:ipo5_mouse(display_long)|uniprotkb:Ranbp5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)|uniprotkb:Ipo5(gene name)|psi-mi:Ipo5(display_short)|uniprotkb:Kpnb3(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076068.1|refseq:XP_006519603.1|ensembl:ENSMUSG00000030662(gene)|ensembl:ENSMUST00000032898(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:Q8BKC5|go:"GO:0006607"(NLS-bearing protein import into nucleus)	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:20927(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZtMfEhsr1lfJDBglaNlc7j4GHZ010090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:2A5F3008731F4CFA|rigid:cMIi1q2ZNGRABeCDJY1zPoYG7sE	false	sufficient binding region:649-1058	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BKC5	uniprotkb:P70315	intact:EBI-643605|uniprotkb:Q3TEG2|uniprotkb:Q7TQC6|uniprotkb:Q9EQ30|ensembl:ENSMUSP00000032898	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:ipo5_mouse(display_long)|uniprotkb:Ranbp5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)|uniprotkb:Ipo5(gene name)|psi-mi:Ipo5(display_short)|uniprotkb:Kpnb3(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652147	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076068.1|refseq:XP_006519603.1|ensembl:ENSMUSG00000030662(gene)|ensembl:ENSMUST00000032898(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:Q8BKC5|go:"GO:0006607"(NLS-bearing protein import into nucleus)	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:20927(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZtMfEhsr1lfJDBglaNlc7j4GHZ010090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:007D55C2EDC9AA4E|rigid:cMIi1q2ZNGRABeCDJY1zPoYG7sE	false	sufficient binding region:654-1097	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BKC5	uniprotkb:P70315	intact:EBI-643605|uniprotkb:Q3TEG2|uniprotkb:Q7TQC6|uniprotkb:Q9EQ30|ensembl:ENSMUSP00000032898	intact:EBI-644195|ensembl:ENSMUSP00000033505	psi-mi:ipo5_mouse(display_long)|uniprotkb:Ranbp5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)|uniprotkb:Ipo5(gene name)|psi-mi:Ipo5(display_short)|uniprotkb:Kpnb3(gene name synonym)	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652167	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076068.1|refseq:XP_006519603.1|ensembl:ENSMUSG00000030662(gene)|ensembl:ENSMUST00000032898(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:Q8BKC5|go:"GO:0006607"(NLS-bearing protein import into nucleus)	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	afcs:10670(primary-reference)|afcs:20927(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZtMfEhsr1lfJDBglaNlc7j4GHZ010090	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	intact-crc:D50739B228FAEE1F|rigid:cMIi1q2ZNGRABeCDJY1zPoYG7sE	false	sufficient binding region:696-1056	sufficient binding region:1-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1E3	uniprotkb:Q04207	intact:EBI-644427|uniprotkb:Q80ZX5|ensembl:ENSMUSP00000021413|uniprotkb:Q3U9W9|uniprotkb:Q3UB40	intact:EBI-644400|uniprotkb:Q62025|ensembl:ENSMUSP00000025867	psi-mi:ikba_mouse(display_long)|uniprotkb:I-kappa-B-alpha(gene name synonym)|uniprotkb:Nfkbia(gene name)|psi-mi:Nfkbia(display_short)|uniprotkb:Ikba(gene name synonym)	psi-mi:tf65_mouse(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Rela(gene name)|psi-mi:Rela(display_short)|uniprotkb:Nfkb3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652280	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035037.2|ensembl:ENSMUSG00000021025(gene)|ensembl:ENSMUST00000021413(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q9Z1E3|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-933542|dip:DIP-36160N	refseq:NP_033071.1|reactome:R-MMU-2871837|reactome:R-MMU-3134963|reactome:R-MMU-3214841|reactome:R-MMU-445989|reactome:R-MMU-448706|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5621575|reactome:R-MMU-9020702|reactome:R-MMU-933542|rcsb pdb:2RAM|rcsb pdb:5U01|rcsb pdb:6GGR|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-209560|ensembl:ENSMUSG00000024927(gene)|ensembl:ENSMUST00000025867(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|mint:Q04207|rcsb pdb:1BFT|rcsb pdb:1IKN|rcsb pdb:1K3Z|rcsb pdb:1LE5|rcsb pdb:1LE9|rcsb pdb:1LEI|rcsb pdb:1MY5|rcsb pdb:1MY7|rcsb pdb:1OY3|rcsb pdb:1RAM|interpro:IPR037059|rcsb pdb:1VKX|rcsb pdb:2I9T|rcsb pdb:2LWW|dip:DIP-6219N	afcs:12430(primary-reference)|afcs:16466(secondary-ac)	-	-	caution:The prey construct contains 15 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:9uG+85E5n7tKNUUDcVTK2fH2UOM10090	rogid:poiJSPJwXK2Om5pfk8z5HwFgK1o10090	intact-crc:1FC77069EDFA1A80|rigid:TnapRWmsu5aA4euGsip1JMZa5mk	false	sufficient binding region:1-271	sufficient binding region:200-430	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q31125	uniprotkb:P11835	intact:EBI-644519|uniprotkb:Q3TVU6|uniprotkb:Q9Z1W1|ensembl:ENSMUSP00000025186|ensembl:ENSMUSP00000130102	intact:EBI-644501|uniprotkb:Q64482	psi-mi:s39a7_mouse(display_long)|uniprotkb:Solute carrier family 39 member 7(gene name synonym)|uniprotkb:Histidine-rich membrane protein Ke4(gene name synonym)|uniprotkb:Slc39a7(gene name)|psi-mi:Slc39a7(display_short)|uniprotkb:H2-Ke4(gene name synonym)|uniprotkb:Hke4(gene name synonym)|uniprotkb:Zrt-, Irt-like protein 7(gene name synonym)	psi-mi:itb2_mouse(display_long)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:Itgb2(gene name)|psi-mi:Itgb2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652445	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001071177.1|refseq:NP_032228.2|ensembl:ENSMUSG00000024327(gene)|ensembl:ENSMUST00000025186(transcript)|ensembl:ENSMUST00000169397(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR003689(Zinc/iron permease)|reactome:R-MMU-442380	refseq:NP_032430.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0043113"(receptor clustering)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990266"(neutrophil migration)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|reactome:R-MMU-166016|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-6798695|dip:DIP-37428N|mint:P11835	afcs:14656(primary-reference)|afcs:23552(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BVLmJQnAanBeKDcJBsaDieohUTk10090	rogid:a6PSt0Keij+/xNNHH2GNomc28SM10090	intact-crc:DD4DE0222D22A098|rigid:AAFukns2dZs3TfNx54DMt9rh/N4	false	sufficient binding region:41-201	sufficient binding region:360-701	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q63932	uniprotkb:Q99M51	intact:EBI-397724|ensembl:ENSMUSP00000121111|uniprotkb:Q9D7B0	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:mp2k2_mouse(display_long)|uniprotkb:Map2k2(gene name)|psi-mi:Map2k2(display_short)|uniprotkb:Mek2(gene name synonym)|uniprotkb:Mkk2(gene name synonym)|uniprotkb:Prkmk2(gene name synonym)|uniprotkb:ERK activator kinase 2(gene name synonym)|uniprotkb:MAPK/ERK kinase 2(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652456	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060502"(epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:2000147"(positive regulation of cell motility)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:Q63932|rcsb pdb:1JKY|reactome:R-MMU-112411|reactome:R-MMU-170968|reactome:R-MMU-445144|reactome:R-MMU-5673000|reactome:R-MMU-5674135|reactome:R-MMU-5674499|ensembl:ENSMUSG00000035027(gene)|ensembl:ENSMUST00000143517(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004712"(protein serine/threonine/tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007507"(heart development)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030878"(thyroid gland development)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0036289"(peptidyl-serine autophosphorylation)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048538"(thymus development)|go:"GO:0048679"(regulation of axon regeneration)|go:"GO:0050772"(positive regulation of axonogenesis)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060324"(face development)|refseq:NP_075627.2|dip:DIP-454N	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:7461(primary-reference)|afcs:6806(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:zFBe4huY3ueH6Rsll7hEcUTUxpI10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:5F795DC704AAB089|rigid:4B1m04ZelqIkeHHEk97dpP8t5l8	false	sufficient binding region:74-401	sufficient binding region:1-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6P6L5	uniprotkb:Q6PDN3	intact:EBI-647885|ensembl:ENSMUSP00000112615	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:q6p6l5_mouse(display_long)|uniprotkb:Mybpc1(gene name)|psi-mi:Mybpc1(display_short)|uniprotkb:8030451F13Rik(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658972	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_780627.2|refseq:NP_001239301.1|ensembl:ENSMUSG00000020061(gene)|ensembl:ENSMUST00000121629(transcript)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006936"(muscle contraction)|go:"GO:0017022"(myosin binding)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|interpro:IPR036179|interpro:IPR040849	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:35660(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Hkez7lXL3VGdHcnkL4Vl+yC+OXQ10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:76A1C02CBEDA21F6|rigid:p7x5LGRycwmTZG8movnFRdrMaFA	false	sufficient binding region:359-662	sufficient binding region:250-550	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P22366	uniprotkb:P22366	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648522	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	afcs:10042(primary-reference)|afcs:10042(secondary-ac)	-	-	caution:The prey construct contains 18 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:B1C37AE8A52E12E5|rigid:2idHNflOZhFcBMIE3JrADi4ITgw	false	sufficient binding region:1-111	sufficient binding region:1-141	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P22366	uniprotkb:P22366	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648534	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	afcs:10042(primary-reference)|afcs:10042(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:7C9B6C03F109F825|rigid:2idHNflOZhFcBMIE3JrADi4ITgw	false	sufficient binding region:5-296	sufficient binding region:1-141	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BP22	uniprotkb:Q60680-1	intact:EBI-646638|uniprotkb:A2AVA5|uniprotkb:A2AVA6|uniprotkb:A2AVA7|uniprotkb:Q7TNQ9|uniprotkb:Q8C2F8|uniprotkb:Q8VDU6|uniprotkb:Q9D2J3|ensembl:ENSMUSP00000103920	intact:EBI-646260	psi-mi:fa92a_mouse(display_long)|uniprotkb:Fam92a(gene name)|psi-mi:Fam92a(display_short)|uniprotkb:Fam92a1(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656550	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080834.3|refseq:NP_001297672.1|ensembl:ENSMUSG00000028218(gene)|ensembl:ENSMUST00000108285(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005814"(centriole)|go:"GO:0005929"(cilium)|go:"GO:0007007"(inner mitochondrial membrane organization)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0035108"(limb morphogenesis)|go:"GO:0035869"(ciliary transition zone)|go:"GO:0036064"(ciliary basal body)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0060271"(cilium assembly)|go:"GO:0061024"(membrane organization)|go:"GO:0097546"(ciliary base)|go:"GO:0097749"(membrane tubulation)|interpro:IPR009602(Protein of unknown function DUF1208)|interpro:IPR027267|interpro:IPR035590	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:53781(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YOOxBao5mTGCEUIpIPPmZsDpmR010090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:4305668E40816195|rigid:OJljcgo412kvYgwyobKQ49DSDg8	false	sufficient binding region:42-235	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ERD8	uniprotkb:Q62406-1	intact:EBI-647060|uniprotkb:Q8BH45|uniprotkb:Q91X89|ensembl:ENSMUSP00000023074	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:parvg_mouse(display_long)|uniprotkb:Parvg(gene name)|psi-mi:Parvg(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657854	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155972.1|refseq:NP_071716.3|refseq:XP_011244008.1|ensembl:ENSMUSG00000022439(gene)|ensembl:ENSMUST00000023074(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR028433|interpro:IPR036872|go:"GO:0005886"(plasma membrane)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:24153(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0M9tnXAjmF+2EQtmFznsK2s7SKo10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:FC438B86A732DA3D|rigid:VnUN9PRPRG6BYputLtq9+k2P4D8	false	sufficient binding region:12-331	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JJ94	uniprotkb:Q9QXJ2	intact:EBI-647574|ensembl:ENSMUSP00000028342	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:ssna1_mouse(display_long)|uniprotkb:Ssna1(gene name)|psi-mi:Ssna1(display_short)|uniprotkb:MNCb-2711(orf name)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658618	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075953.1|ensembl:ENSMUSG00000026966(gene)|ensembl:ENSMUST00000028342(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|interpro:IPR033362|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:24566(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:27XUjsivH0lBLAC9ePhdOlCiXps10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:B0FA850639B36457|rigid:PsHQi3NPV0tjVo1KcFj0NycaFsk	false	sufficient binding region:29-119	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63280	uniprotkb:P22366	intact:EBI-80180|uniprotkb:P50550|uniprotkb:Q15698|uniprotkb:Q6RUT3|uniprotkb:Q86VB3|ensembl:ENSMUSP00000055714|ensembl:ENSMUSP00000134169|ensembl:ENSMUSP00000134261|ensembl:ENSMUSP00000134350|ensembl:ENSMUSP00000134450|ensembl:ENSMUSP00000134491	intact:EBI-525108|uniprotkb:O35916|ensembl:ENSMUSP00000035092	psi-mi:ubc9_mouse(display_long)|uniprotkb:Ube2i(gene name)|psi-mi:Ube2i(display_short)|uniprotkb:Ubc9(gene name synonym)|uniprotkb:Ubce9(gene name synonym)|uniprotkb:Ubce2i(gene name synonym)|uniprotkb:SUMO-protein ligase(gene name synonym)|uniprotkb:Ubiquitin-conjugating enzyme E2 I(gene name synonym)|uniprotkb:Ubiquitin-protein ligase I(gene name synonym)|uniprotkb:Ubiquitin carrier protein I(gene name synonym)|uniprotkb:Ubiquitin carrier protein 9(gene name synonym)|uniprotkb:RING-type E3 SUMO transferase UBC9(gene name synonym)	psi-mi:myd88_mouse(display_long)|uniprotkb:Myd88(gene name)|psi-mi:Myd88(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658749	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001171080.1|refseq:NP_001171081.1|refseq:NP_035795.1|ensembl:ENSMUSG00000015120(gene)|ensembl:ENSMUST00000049911(transcript)|ensembl:ENSMUST00000172618(transcript)|ensembl:ENSMUST00000173084(transcript)|ensembl:ENSMUST00000173713(transcript)|ensembl:ENSMUST00000174001(transcript)|ensembl:ENSMUST00000174031(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001650"(fibrillar center)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0007049"(cell cycle)|go:"GO:0007059"(chromosome segregation)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010469"(regulation of signaling receptor activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0033145"(positive regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043398"(HLH domain binding)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0044388"(small protein activating enzyme binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051301"(cell division)|go:"GO:0061656"(SUMO conjugating enzyme activity)|go:"GO:0071535"(RING-like zinc finger domain binding)|go:"GO:1903755"(positive regulation of SUMO transferase activity)|go:"GO:1990234"(transferase complex)|go:"GO:1990356"(sumoylated E2 ligase complex)|interpro:IPR000608(Ubiquitin-conjugating enzyme, E2)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|interpro:IPR023313|mint:P63280|rcsb pdb:1U9A|rcsb pdb:1U9B|rcsb pdb:2UYZ|rcsb pdb:2VRR|reactome:R-MMU-196791|reactome:R-MMU-3065678|reactome:R-MMU-3108214|reactome:R-MMU-3108232|reactome:R-MMU-3232118|reactome:R-MMU-3232142|reactome:R-MMU-3899300|reactome:R-MMU-4085377|reactome:R-MMU-4090294|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-4655427|reactome:R-MMU-4755510|reactome:R-MMU-5693565|reactome:R-MMU-5693607|reactome:R-MMU-5696395|reactome:R-MMU-8866904|reactome:R-MMU-9615933|refseq:XP_006524111.1|refseq:XP_006524112.1|dip:DIP-29276N	refseq:NP_034981.1|dip:DIP-34957N|ensembl:ENSMUSG00000032508(gene)|ensembl:ENSMUST00000035092(transcript)|go:"GO:0002238"(response to molecule of fungal origin)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002283"(neutrophil activation involved in immune response)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005121"(Toll binding)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0009615"(response to virus)|go:"GO:0009682"(induced systemic resistance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032740"(positive regulation of interleukin-17 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034158"(toll-like receptor 8 signaling pathway)|go:"GO:0035325"(Toll-like receptor binding)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050671"(positive regulation of lymphocyte proliferation)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051607"(defense response to virus)|go:"GO:0060337"(type I interferon signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0070944"(neutrophil-mediated killing of bacterium)|go:"GO:0070976"(TIR domain binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0090557"(establishment of endothelial intestinal barrier)|go:"GO:0140052"(cellular response to oxidised low-density lipoprotein particle stimulus)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:2000338"("regulation of chemokine (C-X-C motif) ligand 1 production")|go:"GO:2000341"("regulation of chemokine (C-X-C motif) ligand 2 production")|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR000488(Death)|interpro:IPR011029(DEATH-like)|interpro:IPR017281(Myeloid differentiation primary response protein MyD88)|interpro:IPR034249|interpro:IPR035897|mint:P22366|go:"GO:0042832"(defense response to protozoan)|reactome:R-MMU-1810476|reactome:R-MMU-209543|reactome:R-MMU-3134963|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-1257604	afcs:10042(primary-reference)|afcs:6257(secondary-ac)	-	-	caution:The prey construct contains 26 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:VV8ByrWqarJUmpoBqQ9EPZiGpFo10090	rogid:4bHizxwWAnvXGR+Uos99jAL3iDU10090	intact-crc:122590978187AECD|rigid:ylGhO9qSivuAEiTTVjsJt5h9lNo	false	sufficient binding region:1-157	sufficient binding region:1-141	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1N5	uniprotkb:Q60680-1	intact:EBI-647702|uniprotkb:Q8HW97|ensembl:ENSMUSP00000070682|ensembl:ENSMUSP00000133428|ensembl:ENSMUSP00000134178	intact:EBI-646260	psi-mi:dx39b_mouse(display_long)|uniprotkb:DEAD box protein UAP56(gene name synonym)|uniprotkb:56 kDa U2AF65-associated protein(gene name synonym)|uniprotkb:HLA-B-associated transcript 1 protein(gene name synonym)|uniprotkb:Ddx39b(gene name)|psi-mi:Ddx39b(display_short)|uniprotkb:Bat1a(gene name synonym)|uniprotkb:Uap56(gene name synonym)|uniprotkb:Bat1(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658759	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062667.1|refseq:NP_001239386.1|ensembl:ENSMUSG00000019432(gene)|ensembl:ENSMUST00000068056(transcript)|ensembl:ENSMUST00000172549(transcript)|ensembl:ENSMUST00000173731(transcript)|go:"GO:0000245"(spliceosomal complex assembly)|go:"GO:0000346"(transcription export complex)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001889"(liver development)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005687"(U4 snRNP)|go:"GO:0005688"(U6 snRNP)|go:"GO:0005737"(cytoplasm)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0008186"(ATP-dependent activity, acting on RNA)|go:"GO:0008380"(RNA splicing)|go:"GO:0010501"(RNA secondary structure unwinding)|go:"GO:0016363"(nuclear matrix)|go:"GO:0016607"(nuclear speck)|go:"GO:0017070"(U6 snRNA binding)|go:"GO:0030621"(U4 snRNA binding)|go:"GO:0032786"(positive regulation of DNA-templated transcription, elongation)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043008"(ATP-dependent protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0046784"(viral mRNA export from host cell nucleus)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000002"(negative regulation of DNA damage checkpoint)|go:"GO:2000573"(positive regulation of DNA biosynthetic process)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|mint:Q9Z1N5|reactome:R-MMU-159236|reactome:R-MMU-72187|reactome:R-MMU-73856|reactome:R-MMU-9013418	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:18215(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:KFD8ORH0BbsAlrCymbikAmnhPVs10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:E748DE036984502E|rigid:6h6cXOSsI6W2m/S/+yV7I3kyobw	false	sufficient binding region:390-428	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CQD1	uniprotkb:Q60680-1	intact:EBI-647712|uniprotkb:Q9DCN5|uniprotkb:Q3UCX7|uniprotkb:Q4VAA1|ensembl:ENSMUSP00000017975	intact:EBI-646260	psi-mi:rab5a_mouse(display_long)|uniprotkb:Rab5a(gene name)|psi-mi:Rab5a(display_short)|uniprotkb:nnyRab5a(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658769	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080163.1|ensembl:ENSMUSG00000017831(gene)|ensembl:ENSMUST00000017975(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006897"(endocytosis)|go:"GO:0006909"(phagocytosis)|go:"GO:0007032"(endosome organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0012505"(endomembrane system)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019001"(guanyl nucleotide binding)|go:"GO:0019003"(GDP binding)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030670"(phagocytic vesicle membrane)|go:"GO:0032009"(early phagosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036465"(synaptic vesicle recycling)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042470"(melanosome)|go:"GO:0042589"(zymogen granule membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045921"(positive regulation of exocytosis)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051021"(GDP-dissociation inhibitor binding)|go:"GO:0051036"(regulation of endosome size)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0055037"(recycling endosome)|go:"GO:0098559"(cytoplasmic side of early endosome membrane)|go:"GO:0098842"(postsynaptic early endosome)|go:"GO:0098993"(anchored component of synaptic vesicle membrane)|go:"GO:0150093"(amyloid-beta clearance by transcytosis)|go:"GO:2000286"(receptor internalization involved in canonical Wnt signaling pathway)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001806(Ras GTPase)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|reactome:R-MMU-1660499|reactome:R-MMU-8856828|reactome:R-MMU-8873719|reactome:R-MMU-8876198|reactome:R-MMU-983231|go:"GO:0008021"(synaptic vesicle)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:55749(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TleQFpdeUdtlHFp7sMsgWpx6p8E10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:D6ACE0D1F59FC5EF|rigid:ibFog47aP0ylCngdm76UWie7ogw	false	sufficient binding region:7-215	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80WE4	uniprotkb:Q60680-1	intact:EBI-647727|uniprotkb:E9QPW5|uniprotkb:Q3V347|uniprotkb:Q80VC0|uniprotkb:Q8BLI2|uniprotkb:Q99PT5|ensembl:ENSMUSP00000084599	intact:EBI-646260	psi-mi:ki20b_mouse(display_long)|uniprotkb:Kinesin-related motor interacting with PIN1(gene name synonym)|uniprotkb:Kinesin family member 20B(gene name synonym)|uniprotkb:Kif20b(gene name)|psi-mi:Kif20b(display_short)|uniprotkb:M-phase phosphoprotein 1(gene name synonym)|uniprotkb:Mphosph1(gene name synonym)	psi-mi:q60680-1(display_long)|uniprotkb:Chuk(gene name)|psi-mi:Chuk(display_short)|uniprotkb:Ikka(gene name synonym)|uniprotkb:Conserved helix-loop-helix ubiquitous kinase(gene name synonym)|uniprotkb:I-kappa-B kinase 1(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase alpha(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658779	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_898867.1|refseq:XP_006527143.1|refseq:XP_006527144.1|refseq:XP_006527149.1|ensembl:ENSMUSG00000024795(gene)|ensembl:ENSMUST00000087341(transcript)|go:"GO:0001843"(neural tube closure)|go:"GO:0003777"(microtubule motor activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007049"(cell cycle)|go:"GO:0007088"(regulation of mitotic nuclear division)|go:"GO:0008017"(microtubule binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008574"(plus-end-directed microtubule motor activity)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0035372"(protein localization to microtubule)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045171"(intercellular bridge)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050699"(WW domain binding)|go:"GO:0051233"(spindle midzone)|go:"GO:0051301"(cell division)|go:"GO:0070201"(regulation of establishment of protein localization)|go:"GO:0070938"(contractile ring)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903438"(positive regulation of mitotic cytokinetic process)|go:"GO:1990023"(mitotic spindle midzone)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001224"(positive regulation of neuron migration)|interpro:IPR001752(Kinesin, motor region)|interpro:IPR019821|interpro:IPR027417|interpro:IPR027640|interpro:IPR028828|reactome:R-MMU-2132295|reactome:R-MMU-6811434|reactome:R-MMU-983189|go:"GO:0015630"(microtubule cytoskeleton)	intact:EBI-646245(ikka_mouse)	afcs:14057(primary-reference)|afcs:58290(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:yqb8WY+HdiM7MS+jFwB+3byvf7k10090	rogid:FtGkCawP52shlrOb2CCs9OGLIKA10090	intact-crc:D1543F8A8709ACB4|rigid:k6ZJ295loHoLY0UfxsJntYYuk9s	false	sufficient binding region:581-781	sufficient binding region:400-650	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R4E9	uniprotkb:Q6PDN3	intact:EBI-457043|uniprotkb:Q8BUQ1|uniprotkb:Q8BX29|uniprotkb:Q8R3V0|uniprotkb:Q8R4E8|ensembl:ENSMUSP00000006760	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:cdt1_mouse(display_long)|uniprotkb:Double parked homolog(gene name synonym)|uniprotkb:Retroviral insertion site 2 protein(gene name synonym)|uniprotkb:Cdt1(gene name)|psi-mi:Cdt1(display_short)|uniprotkb:Ris2(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658789	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080290.3|go:"GO:0035563"(positive regulation of chromatin binding)|go:"GO:0045740"(positive regulation of DNA replication)|ensembl:ENSMUSG00000006585(gene)|ensembl:ENSMUST00000006760(transcript)|go:"GO:0000076"(DNA replication checkpoint signaling)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000776"(kinetochore)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0007059"(chromosome segregation)|go:"GO:0016604"(nuclear body)|go:"GO:0030174"(regulation of DNA-dependent DNA replication initiation)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0033044"(regulation of chromosome organization)|go:"GO:0033262"(regulation of nuclear cell cycle DNA replication)|interpro:IPR032054|interpro:IPR036390|interpro:IPR038090|rcsb pdb:2KLO|rcsb pdb:2RQQ|rcsb pdb:2ZXX|rcsb pdb:3A4C|reactome:R-MMU-68827|reactome:R-MMU-68867|reactome:R-MMU-68949|reactome:R-MMU-68962|go:"GO:0051301"(cell division)|go:"GO:0051315"(attachment of mitotic spindle microtubules to kinetochore)|go:"GO:0051383"(kinetochore organization)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:0071163"(DNA replication preinitiation complex assembly)|go:"GO:0072708"(response to sorbitol)|go:"GO:1902426"(deactivation of mitotic spindle assembly checkpoint)|go:"GO:1902595"(regulation of DNA replication origin binding)|go:"GO:1905341"(negative regulation of protein localization to kinetochore)|go:"GO:1905342"(positive regulation of protein localization to kinetochore)|go:"GO:2000105"(positive regulation of DNA-dependent DNA replication)|interpro:IPR014939(DNA replication factor CDT1-like)	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:40115(secondary-ac)|afcs:35660(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:GkxXG8geC2JHCrw2tNWQzIhf+W410090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:BB20C920A9D2BCD5|rigid:kY2t4wNwufsXzq7ANtAGzFC5k1w	false	sufficient binding region:2-385	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26043	uniprotkb:Q6PDN3	intact:EBI-647737|uniprotkb:Q3TS85|uniprotkb:Q9QW27|ensembl:ENSMUSP00000000590|ensembl:ENSMUSP00000128249	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:radi_mouse(display_long)|uniprotkb:ESP10(gene name synonym)|uniprotkb:Rdx(gene name)|psi-mi:Rdx(display_short)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658799	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001098086.1|refseq:NP_033067.2|dip:DIP-29091N|ensembl:ENSMUSG00000032050(gene)|ensembl:ENSMUST00000000590(transcript)|ensembl:ENSMUST00000163153(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005912"(adherens junction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030033"(microvillus assembly)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0032154"(cleavage furrow)|go:"GO:0032231"(regulation of actin filament bundle assembly)|go:"GO:0032420"(stereocilium)|go:"GO:0034111"(negative regulation of homotypic cell-cell adhesion)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043209"(myelin sheath)|go:"GO:0045176"(apical protein localization)|go:"GO:0045177"(apical part of cell)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0051016"(barbed-end actin filament capping)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097067"(cellular response to thyroid hormone stimulus)|go:"GO:1900027"(regulation of ruffle assembly)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903392"(negative regulation of adherens junction organization)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P26043|rcsb pdb:1GC6|rcsb pdb:1GC7|rcsb pdb:1J19|rcsb pdb:2D10|rcsb pdb:2D11|rcsb pdb:2D2Q|rcsb pdb:2EMS|rcsb pdb:2EMT|rcsb pdb:2YVC|rcsb pdb:2ZPY|rcsb pdb:3X23|reactome:R-MMU-437239	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:15174(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:d7wqsdTau9b92O3q6LW+/pyKL1w10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:DB08A26E9E35A98C|rigid:qmqV3l8/7QkQdtbrul06clTt83Y	false	sufficient binding region:259-434	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P03966	uniprotkb:Q6PDN3	intact:EBI-647752|uniprotkb:Q61978|ensembl:ENSMUSP00000045993|ensembl:ENSMUSP00000114225	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:mycn_mouse(display_long)|uniprotkb:Mycn(gene name)|psi-mi:Mycn(display_short)|uniprotkb:Nmyc(gene name synonym)|uniprotkb:Nmyc1(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658809	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032735.3|dip:DIP-49592N|ensembl:ENSMUSG00000037169(gene)|ensembl:ENSMUST00000043396(transcript)|ensembl:ENSMUST00000130990(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001502"(cartilage condensation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0019900"(kinase binding)|go:"GO:0030324"(lung development)|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0045607"(regulation of inner ear auditory receptor cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048704"(embryonic skeletal system morphogenesis)|go:"GO:0048712"(negative regulation of astrocyte differentiation)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR002418(Transcription regulator Myc)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR012682(Transcription regulator Myc, N-terminal)|interpro:IPR036638	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:14900(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:J+RjU57FyHczGnzHYpNaUKOiw6k10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:197A918FEE41E9AE|rigid:rcnDpp2TeahImfOiJskCs5wwD58	false	sufficient binding region:191-350	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60865	uniprotkb:P05125	intact:EBI-647767|uniprotkb:Q6IMN3|uniprotkb:Q7TT26|uniprotkb:Q60758|uniprotkb:Q61620|ensembl:ENSMUSP00000028607|ensembl:ENSMUSP00000106777	intact:EBI-641688|uniprotkb:Q5FW59|ensembl:ENSMUSP00000099520	psi-mi:capr1_mouse(display_long)|uniprotkb:Cytoplasmic activation- and proliferation-associated protein 1(gene name synonym)|uniprotkb:GPI-anchored membrane protein 1(gene name synonym)|uniprotkb:GPI-anchored protein p137(gene name synonym)|uniprotkb:Membrane component chromosome 11 surface marker 1(gene name synonym)|uniprotkb:Caprin1(gene name)|psi-mi:Caprin1(display_short)|uniprotkb:Gpiap(gene name synonym)|uniprotkb:Gpiap1(gene name synonym)|uniprotkb:Gpip137(gene name synonym)|uniprotkb:M11s1(gene name synonym)|uniprotkb:G5E5(orf name)|uniprotkb:Rng105(gene name synonym)|uniprotkb:RNA granule protein 105(gene name synonym)	psi-mi:anf_mouse(display_long)|uniprotkb:Nppa(gene name)|psi-mi:Nppa(display_short)|uniprotkb:Pnd(gene name synonym)|uniprotkb:Atrial natriuretic factor prohormone(gene name synonym)|uniprotkb:Atrial natriuretic peptide prohormone(gene name synonym)|uniprotkb:Atriopeptigen(gene name synonym)|uniprotkb:Cardiodilatin(gene name synonym)|uniprotkb:preproCDD-ANF(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658819	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001104759.1|refseq:NP_001104760.1|refseq:NP_001104761.1|refseq:NP_001104762.1|refseq:NP_058019.2|ensembl:ENSMUSG00000027184(gene)|ensembl:ENSMUST00000028607(transcript)|ensembl:ENSMUST00000111147(transcript)|go:"GO:0000932"(P-body)|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030425"(dendrite)|go:"GO:0031252"(cell leading edge)|go:"GO:0045202"(synapse)|go:"GO:0050775"(positive regulation of dendrite morphogenesis)|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR022070|interpro:IPR028816|interpro:IPR041637|mint:Q60865	ensembl:ENSMUSG00000041616(gene)|ensembl:ENSMUST00000103230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005903"(brush border)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042311"(vasodilation)|go:"GO:0042629"(mast cell granule)|go:"GO:0042995"(cell projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051427"(hormone receptor binding)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071855"(neuropeptide receptor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|go:"GO:1903766"(positive regulation of potassium ion export across plasma membrane)|go:"GO:1903815"(negative regulation of collecting lymphatic vessel constriction)|interpro:IPR000663(Natriuretic peptide)|interpro:IPR002407(Natriuretic peptide, atrial type)|interpro:IPR030480|mint:P05125|reactome:R-MMU-5578768|refseq:NP_032751.1	afcs:33838(primary-reference)|afcs:17700(secondary-ac)	-	-	caution:The prey construct contains 63 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:e+Dcb+82jx+CoLhlGBbdSG62dPU10090	rogid:1o0E9kPQY62MAxAsrX0mhfMzslI10090	intact-crc:F53A951CAEC832A4|rigid:i0+1hwh7EJAZ3pdE1D8qcZhsg6c	false	sufficient binding region:?-?	sufficient binding region:1-152	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q00612	uniprotkb:P05125	intact:EBI-647776|ensembl:ENSMUSP00000004327	intact:EBI-641688|uniprotkb:Q5FW59|ensembl:ENSMUSP00000099520	psi-mi:g6pd1_mouse(display_long)|uniprotkb:G6pdx(gene name)|psi-mi:G6pdx(display_short)|uniprotkb:G6pd(gene name synonym)|uniprotkb:G6pd-1(gene name synonym)	psi-mi:anf_mouse(display_long)|uniprotkb:Nppa(gene name)|psi-mi:Nppa(display_short)|uniprotkb:Pnd(gene name synonym)|uniprotkb:Atrial natriuretic factor prohormone(gene name synonym)|uniprotkb:Atrial natriuretic peptide prohormone(gene name synonym)|uniprotkb:Atriopeptigen(gene name synonym)|uniprotkb:Cardiodilatin(gene name synonym)|uniprotkb:preproCDD-ANF(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658831	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032088.1|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006098"(pentose-phosphate shunt)|go:"GO:0006695"(cholesterol biosynthetic process)|go:"GO:0006739"(NADP metabolic process)|go:"GO:0006740"(NADPH regeneration)|go:"GO:0006741"(NADP biosynthetic process)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0009051"(pentose-phosphate shunt, oxidative branch)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010734"(negative regulation of protein glutathionylation)|go:"GO:0019322"(pentose biosynthetic process)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0034451"(centriolar satellite)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043249"(erythrocyte maturation)|go:"GO:0043523"(regulation of neuron apoptotic process)|go:"GO:0045471"(response to ethanol)|go:"GO:0046390"(ribose phosphate biosynthetic process)|go:"GO:0048821"(erythrocyte development)|go:"GO:0050661"(NADP binding)|go:"GO:0051156"(glucose 6-phosphate metabolic process)|go:"GO:0005634"(nucleus)|ensembl:ENSMUSG00000031400(gene)|ensembl:ENSMUST00000004327(transcript)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002033"(angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure)|go:"GO:0004345"(glucose-6-phosphate dehydrogenase activity)|go:"GO:0005536"(glucose binding)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001282(Glucose-6-phosphate dehydrogenase)|interpro:IPR019796|interpro:IPR022674|interpro:IPR022675|interpro:IPR036291|mint:Q00612|reactome:R-MMU-5628897|reactome:R-MMU-71336|go:"GO:1904879"(positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)	ensembl:ENSMUSG00000041616(gene)|ensembl:ENSMUST00000103230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005903"(brush border)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042311"(vasodilation)|go:"GO:0042629"(mast cell granule)|go:"GO:0042995"(cell projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051427"(hormone receptor binding)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071855"(neuropeptide receptor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|go:"GO:1903766"(positive regulation of potassium ion export across plasma membrane)|go:"GO:1903815"(negative regulation of collecting lymphatic vessel constriction)|interpro:IPR000663(Natriuretic peptide)|interpro:IPR002407(Natriuretic peptide, atrial type)|interpro:IPR030480|mint:P05125|reactome:R-MMU-5578768|refseq:NP_032751.1	afcs:33838(primary-reference)|afcs:14370(secondary-ac)	-	-	caution:The prey construct contains 14 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2CPZ84pzjTPslBJfopjgJR5+fyw10090	rogid:1o0E9kPQY62MAxAsrX0mhfMzslI10090	intact-crc:C1BA49E2529B043C|rigid:SfoupFi9aPKmxWAhHWBmhOdphCo	false	sufficient binding region:2-180	sufficient binding region:1-152	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P52480-1	uniprotkb:P05125	intact:EBI-647795|ensembl:ENSMUSP00000034834	intact:EBI-641688|uniprotkb:Q5FW59|ensembl:ENSMUSP00000099520	psi-mi:p52480-1(display_long)|uniprotkb:Pkm(gene name)|psi-mi:Pkm(display_short)|uniprotkb:Pk3(gene name synonym)|uniprotkb:Pkm2(gene name synonym)|uniprotkb:Pykm(gene name synonym)|uniprotkb:Pyruvate kinase muscle isozyme(gene name synonym)|uniprotkb:PKM2(isoform synonym)	psi-mi:anf_mouse(display_long)|uniprotkb:Nppa(gene name)|psi-mi:Nppa(display_short)|uniprotkb:Pnd(gene name synonym)|uniprotkb:Atrial natriuretic factor prohormone(gene name synonym)|uniprotkb:Atrial natriuretic peptide prohormone(gene name synonym)|uniprotkb:Atriopeptigen(gene name synonym)|uniprotkb:Cardiodilatin(gene name synonym)|uniprotkb:preproCDD-ANF(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658841	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-647785(kpym_mouse)|ensembl:ENSMUSG00000032294(gene)|ensembl:ENSMUST00000034834(transcript)	ensembl:ENSMUSG00000041616(gene)|ensembl:ENSMUST00000103230(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0003085"(negative regulation of systemic arterial blood pressure)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005184"(neuropeptide hormone activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005903"(brush border)|go:"GO:0006182"(cGMP biosynthetic process)|go:"GO:0006457"(protein folding)|go:"GO:0007168"(receptor guanylyl cyclase signaling pathway)|go:"GO:0007218"(neuropeptide signaling pathway)|go:"GO:0007565"(female pregnancy)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010753"(positive regulation of cGMP-mediated signaling)|go:"GO:0014898"(cardiac muscle hypertrophy in response to stress)|go:"GO:0019934"(cGMP-mediated signaling)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0042311"(vasodilation)|go:"GO:0042629"(mast cell granule)|go:"GO:0042995"(cell projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043508"(negative regulation of JUN kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051427"(hormone receptor binding)|go:"GO:0060372"(regulation of atrial cardiac muscle cell membrane repolarization)|go:"GO:0060452"(positive regulation of cardiac muscle contraction)|go:"GO:0061049"(cell growth involved in cardiac muscle cell development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071855"(neuropeptide receptor binding)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:1902261"(positive regulation of delayed rectifier potassium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1903595"(positive regulation of histamine secretion by mast cell)|go:"GO:1903766"(positive regulation of potassium ion export across plasma membrane)|go:"GO:1903815"(negative regulation of collecting lymphatic vessel constriction)|interpro:IPR000663(Natriuretic peptide)|interpro:IPR002407(Natriuretic peptide, atrial type)|interpro:IPR030480|mint:P05125|reactome:R-MMU-5578768|refseq:NP_032751.1	afcs:33838(primary-reference)|afcs:16558(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SWQx3aPATcnlExhyy8afjcrB+xo10090	rogid:1o0E9kPQY62MAxAsrX0mhfMzslI10090	intact-crc:F5ACA0A54EE53E2C|rigid:tfdNgxgy5Cag9eJtk9Goyfx6opE	false	sufficient binding region:?-?	sufficient binding region:1-152	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P22893	uniprotkb:Q9QXJ2	intact:EBI-647803|uniprotkb:P11520|ensembl:ENSMUSP00000057815	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:ttp_mouse(display_long)|uniprotkb:Zinc finger protein 36(gene name synonym)|uniprotkb:Growth factor-inducible nuclear protein NUP475(gene name synonym)|uniprotkb:TPA-induced sequence 11(gene name synonym)|uniprotkb:Zfp36(gene name)|psi-mi:Zfp36(display_short)|uniprotkb:Tis11(gene name synonym)|uniprotkb:Tis11a(gene name synonym)|uniprotkb:Nup475(gene name synonym)|uniprotkb:Tristetraprolin(gene name synonym)|uniprotkb:Ttp(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658851	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035886.1|ensembl:ENSMUSG00000044786(gene)|ensembl:ENSMUST00000051241(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000289"("nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0000932"(P-body)|go:"GO:0003677"(DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006402"(mRNA catabolic process)|go:"GO:0009611"(response to wounding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010837"(regulation of keratinocyte proliferation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019957"(C-C chemokine binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031086"(nuclear-transcribed mRNA catabolic process, deadenylation-independent decay)|go:"GO:0032680"(regulation of tumor necrosis factor production)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032897"(negative regulation of viral transcription)|go:"GO:0035278"(miRNA-mediated gene silencing by inhibition of translation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035925"(mRNA 3'-UTR AU-rich region binding)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042594"(response to starvation)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045647"(negative regulation of erythrocyte differentiation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050779"(RNA destabilization)|go:"GO:0051028"(mRNA transport)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0070578"(RISC-loading complex)|go:"GO:0070935"(3'-UTR-mediated mRNA stabilization)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:1901835"(positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA)|go:"GO:1902172"(regulation of keratinocyte apoptotic process)|go:"GO:1904246"(negative regulation of polynucleotide adenylyltransferase activity)|go:"GO:1904582"(positive regulation of intracellular mRNA localization)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|interpro:IPR000571(Zinc finger, CCCH-type)|interpro:IPR036855|rcsb pdb:1M9O|reactome:R-MMU-450513	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:16962(secondary-ac)	-	-	caution:The prey construct contains 11 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:cqk/T7+rfnB3UkeawYWXFkx1VfM10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:062EF0E58A16C66B|rigid:XB/PiJ0mmulJsH4FJP0vQw/5WMw	false	sufficient binding region:1-131	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:Q9QXJ2	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658861	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:12352(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:6E0AAEC847B9BB3F|rigid:COUznCf/NEMkkzQvrIeDeegPy4Y	false	sufficient binding region:665-796	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R5C8	uniprotkb:P63085	intact:EBI-647813|uniprotkb:Q8C155|uniprotkb:G5E8Q2|ensembl:ENSMUSP00000106264|ensembl:ENSMUSP00000106266	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:zmy11_mouse(display_long)|uniprotkb:Zmynd11(gene name)|psi-mi:Zmynd11(display_short)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658871	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006516569.1|refseq:NP_001186070.1|refseq:NP_001334403.1|refseq:NP_001334405.1|dip:DIP-49596N|ensembl:ENSMUSG00000021156(gene)|ensembl:ENSMUST00000110634(transcript)|ensembl:ENSMUST00000110636(transcript)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0006325"(chromatin organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0034243"(regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0035064"(methylated histone binding)|go:"GO:0042393"(histone binding)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046329"(negative regulation of JNK cascade)|go:"GO:0051607"(defense response to virus)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000313(PWWP)|interpro:IPR001487(Bromodomain)|interpro:IPR001965(Zinc finger, PHD-type)|interpro:IPR002893(Zinc finger, MYND-type)|interpro:IPR011011(Zinc finger, FYVE/PHD-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR019786|interpro:IPR019787|interpro:IPR035505|interpro:IPR036427|mint:Q8R5C8|rcsb pdb:4N4G|rcsb pdb:4N4H|rcsb pdb:4N4I	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:54939(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:xxSgkZdMc1DQrhsIcIT6vnKBaFQ10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:C8CB9F641E3EF6F3|rigid:CN1ZGMc4N2Q91hqYtiOey8A4g/s	false	sufficient binding region:469-602	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EQS3	uniprotkb:P47713	intact:EBI-647823|uniprotkb:O88308|uniprotkb:Q8R048|ensembl:ENSMUSP00000030400	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:mycbp_mouse(display_long)|uniprotkb:Associate of Myc 1(gene name synonym)|uniprotkb:Mycbp(gene name)|psi-mi:Mycbp(display_short)|uniprotkb:Amy1(gene name synonym)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658881	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062634.2|ensembl:ENSMUSG00000028647(gene)|ensembl:ENSMUST00000030400(transcript)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR026060	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	afcs:15036(primary-reference)|afcs:18787(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:giUYDjBm16KI4fVDEi/bRdoJMdk10090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:E9F4CAF745B2302A|rigid:jmVttoW/KZ2fDsNC2hADMWnqikA	false	sufficient binding region:2-103	sufficient binding region:450-701	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99N69	uniprotkb:Q62406-1	intact:EBI-647829|ensembl:ENSMUSP00000025601	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:lpxn_mouse(display_long)|uniprotkb:Lpxn(gene name)|psi-mi:Lpxn(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658892	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598913.1|ensembl:ENSMUSG00000024696(gene)|ensembl:ENSMUST00000025601(transcript)|go:"GO:0002102"(podosome)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0016607"(nuclear speck)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0042995"(cell projection)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050859"(negative regulation of B cell receptor signaling pathway)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR017305(Leupaxin)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:55458(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:WtqOOPk5nAfCJ6IkrIq9TiP1Bew10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:6468887C33BA305F|rigid:Jlg4Ok+HPcgHe/hlt/fn0NGEStA	false	sufficient binding region:163-386	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BX65	uniprotkb:Q62406-1	intact:EBI-647834|uniprotkb:Q3T9H3|uniprotkb:Q6NXM1|uniprotkb:Q8BJS3|ensembl:ENSMUSP00000099186|ensembl:ENSMUSP00000113050|ensembl:ENSMUSP00000140208	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:mdfic_mouse(display_long)|uniprotkb:I-mfa domain-containing protein(gene name synonym)|uniprotkb:Kidney cell line-derived transcript 1(gene name synonym)|uniprotkb:Mdfic(gene name)|psi-mi:Mdfic(display_short)|uniprotkb:Kdt1(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658902	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_780297.3|ensembl:ENSMUSG00000041390(gene)|ensembl:ENSMUST00000101663(transcript)|ensembl:ENSMUST00000120512(transcript)|ensembl:ENSMUST00000189359(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007257"(obsolete activation of JUN kinase activity)|go:"GO:0030111"(regulation of Wnt signaling pathway)|go:"GO:0030332"(cyclin binding)|go:"GO:0030957"(Tat protein binding)|go:"GO:0042308"(negative regulation of protein import into nucleus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0050434"(positive regulation of viral transcription)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR026134	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:54297(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:a+63rlYRuavrgCannuL9JIiEESY10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:604840A7F7FC871E|rigid:O1Y72WoPs501/x+Zfu9cUK23ci0	false	sufficient binding region:17-247	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08207	uniprotkb:Q62406-1	intact:EBI-643986|ensembl:ENSMUSP00000036949|ensembl:ENSMUSP00000130712	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:s10aa_mouse(display_long)|uniprotkb:S100 calcium-binding protein A10(gene name synonym)|uniprotkb:Calpactin-1 light chain(gene name synonym)|uniprotkb:Calpactin I light chain(gene name synonym)|uniprotkb:p10 protein(gene name synonym)|uniprotkb:p11(gene name synonym)|uniprotkb:Cellular ligand of annexin II(gene name synonym)|uniprotkb:S100a10(gene name)|psi-mi:S100a10(display_short)|uniprotkb:Cal1l(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658912	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033138.1|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990665"(AnxA2-p11 complex)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR028476|mint:P08207|reactome:R-MMU-75205|go:"GO:0072659"(protein localization to plasma membrane)|ensembl:ENSMUSG00000041959(gene)|ensembl:ENSMUST00000045756(transcript)|ensembl:ENSMUST00000170612(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:52666(secondary-ac)	-	-	caution:The prey construct contains 22 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZMDpz9SmMc3cQ195GiMFbhaCuR410090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:FCEF39408057A05D|rigid:tNz4N7czB8zLd7llJTFmBtI7DMU	false	sufficient binding region:2-97	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99NH0	uniprotkb:Q62406-1	intact:EBI-647840|uniprotkb:Q3TV99|uniprotkb:Q5F4T7|uniprotkb:Q6PG69|uniprotkb:Q6ZQ66|uniprotkb:Q8CHT4|ensembl:ENSMUSP00000014421	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:anr17_mouse(display_long)|uniprotkb:Foe(gene name synonym)|uniprotkb:Kiaa0697(gene name synonym)|uniprotkb:Gene trap ankyrin repeat protein(gene name synonym)|uniprotkb:Ankyrin repeat domain-containing protein FOE(gene name synonym)|uniprotkb:Ankrd17(gene name)|psi-mi:Ankrd17(display_short)|uniprotkb:Gtar(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658922	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_112148.2|ensembl:ENSMUSG00000055204(gene)|ensembl:ENSMUST00000014421(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001955"(blood vessel maturation)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006275"(regulation of DNA replication)|go:"GO:0007492"(endoderm development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0051151"(negative regulation of smooth muscle cell differentiation)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900245"(positive regulation of MDA-5 signaling pathway)|go:"GO:1900246"(positive regulation of RIG-I signaling pathway)|interpro:IPR002110(Ankyrin)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR020683|interpro:IPR036612|interpro:IPR036770|mint:Q99NH0	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:33828(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c/59Xwrg6uFRRx34dzmzkER9Lik10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:E4D79CD4B1D8E96A|rigid:0am87xpV1ftiNalIENDYkJ4L16g	false	sufficient binding region:?-?	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P10107	uniprotkb:Q62406-1	intact:EBI-647848|ensembl:ENSMUSP00000025561|ensembl:ENSMUSP00000158305	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:anxa1_mouse(display_long)|uniprotkb:Annexin-1(gene name synonym)|uniprotkb:Annexin I(gene name synonym)|uniprotkb:Lipocortin I(gene name synonym)|uniprotkb:Calpactin II(gene name synonym)|uniprotkb:Chromobindin-9(gene name synonym)|uniprotkb:p35(gene name synonym)|uniprotkb:Phospholipase A2 inhibitory protein(gene name synonym)|uniprotkb:Anxa1(gene name)|psi-mi:Anxa1(display_short)|uniprotkb:Anx1(gene name synonym)|uniprotkb:Lpc1(gene name synonym)|uniprotkb:Lpc-1(gene name synonym)|uniprotkb:Calpactin-2(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658932	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034860.2|ensembl:ENSMUSG00000024659(gene)|ensembl:ENSMUST00000025561(transcript)|ensembl:ENSMUST00000235280(transcript)|go:"GO:0001533"(cornified envelope)|go:"GO:0001780"(neutrophil homeostasis)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002250"(adaptive immune response)|go:"GO:0045629"(negative regulation of T-helper 2 cell differentiation)|go:"GO:0045920"(negative regulation of exocytosis)|go:"GO:0046632"(alpha-beta T cell differentiation)|go:"GO:0046883"(regulation of hormone secretion)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050709"(negative regulation of protein secretion)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070459"(prolactin secretion)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071385"(cellular response to glucocorticoid stimulus)|go:"GO:0071621"(granulocyte chemotaxis)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097350"(neutrophil clearance)|go:"GO:1900087"(positive regulation of G1/S transition of mitotic cell cycle)|go:"GO:1900138"(negative regulation of phospholipase A2 activity)|go:"GO:1990814"(DNA/DNA annealing activity)|interpro:IPR001464(Annexin)|interpro:IPR002388(Annexin, type I)|interpro:IPR018252|interpro:IPR018502|interpro:IPR037104|mint:P10107|reactome:R-MMU-416476|reactome:R-MMU-418594|reactome:R-MMU-444473|go:"GO:0002548"(monocyte chemotaxis)|go:"GO:0002685"(regulation of leukocyte migration)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006909"(phagocytosis)|go:"GO:0006954"(inflammatory response)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007187"(G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0009986"(cell surface)|go:"GO:0010165"(response to X-ray)|go:"GO:0014839"(myoblast migration involved in skeletal muscle regeneration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0018149"(peptide cross-linking)|go:"GO:0019834"(phospholipase A2 inhibitor activity)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030073"(insulin secretion)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030850"(prostate gland development)|go:"GO:0031018"(endocrine pancreas development)|go:"GO:0031232"(extrinsic component of external side of plasma membrane)|go:"GO:0031313"(extrinsic component of endosome membrane)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0031514"(motile cilium)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032355"(response to estradiol)|go:"GO:0032508"(DNA duplex unwinding)|go:"GO:0032652"(regulation of interleukin-1 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033031"(positive regulation of neutrophil apoptotic process)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0036121"(double-stranded DNA helicase activity)|go:"GO:0042063"(gliogenesis)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042493"|go:"GO:0042629"(mast cell granule)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0044849"(estrous cycle)|go:"GO:0045087"(innate immune response)|go:"GO:0045627"(positive regulation of T-helper 1 cell differentiation)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:16338(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:V9sZHzXdA0iCeXidE8a0ahnWFoE10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:9B031A6E87A2E94A|rigid:9i594g16Irri9vRuBZtwNFZRgyU	false	sufficient binding region:27-339	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63085	intact:EBI-687980	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	afcs:58422	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:mll2_mouse_protein(display_short)|psi-mi:EBI-687980(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688493	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	-	afcs:58122(secondary-ac)|afcs:17112(primary-reference)|afcs:58122(primary-reference)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"similar to human Myeloid/lymphoid or mixed-lineage leukemia protein 2 (90%)"|comment:AfCS Y2H protein 58122. Translated from nucleotide sequence.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rogid:F0VCeE8RmWjHjgm8TR6EQ1iaSwQ10090	intact-crc:FEBA9E246AFA4667|rigid:ZtXd7cPNXoTd/cctnARcSfwUiXQ	false	sufficient binding region:1-358	sufficient binding region:1095-1388	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-683404	uniprotkb:Q9QXJ2	-	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:lrrfip1_mouse_protei(display_short)|psi-mi:EBI-683404(display_long)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688559	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	afcs:35834(primary-reference)	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:35834(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"leucine rich repeat (in FLII) interacting protein 1, alt. transcript (678); TAR RNA interacting protein; TRIP; FLI LRR associated protein; FLAP; HUFI-1; Fliiap1"|comment:"AfCS Y2H protein. Sequence retrived from cross-reference; Entrez Gene ID: 16978."|comment:"similar to mouse FLI-LRR associated protein-1 (93%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:VtmVBIWUtmRqzCV8jeV9veWFXo010090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:F5024A7514A6B243|rigid:dvOn8+WUO2aVu6f09/OAn0kCt8w	false	sufficient binding region:309-362	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WU78	uniprotkb:P11798-2	intact:EBI-641897|uniprotkb:Q3TED2|uniprotkb:O88695|uniprotkb:O89014|uniprotkb:Q8BSL8|uniprotkb:Q8R0H5|uniprotkb:Q99LR3|uniprotkb:Q9QZN8|ensembl:ENSMUSP00000035086	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:pdc6i_mouse(display_long)|uniprotkb:ALG-2-interacting protein X(gene name synonym)|uniprotkb:ALG-2-interacting protein 1(gene name synonym)|uniprotkb:E2F1-inducible protein(gene name synonym)|uniprotkb:Eig2(gene name synonym)|uniprotkb:Pdcd6ip(gene name)|psi-mi:Pdcd6ip(display_short)|uniprotkb:Aip1(gene name synonym)|uniprotkb:Alix(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652662	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001158149.1|refseq:NP_001158150.1|refseq:NP_035182.2|ensembl:ENSMUSG00000032504(gene)|ensembl:ENSMUST00000035086(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0000915"(actomyosin contractile ring assembly)|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006915"(apoptotic process)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0031871"(proteinase activated receptor binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045199"(maintenance of epithelial cell apical/basal polarity)|go:"GO:0046755"(viral budding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0061952"(midbody abscission)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0090543"(Flemming body)|go:"GO:0090559"(regulation of membrane permeability)|go:"GO:0042470"(melanosome)|go:"GO:0042641"(actomyosin)|go:"GO:0090611"(ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:1903543"(positive regulation of exosomal secretion)|go:"GO:0043209"(myelin sheath)|go:"GO:1903551"(regulation of extracellular exosome assembly)|go:"GO:1903553"(positive regulation of extracellular exosome assembly)|interpro:IPR004328(BRO1)|interpro:IPR025304|interpro:IPR038499|mint:Q9WU78|reactome:R-MMU-5213460|reactome:R-MMU-5675482|dip:DIP-41418N	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:12352(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHHuK3MilHPoz71+777a7S2Ijrw10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:D8E9A0F3B3A6AB97|rigid:WhmWQx23bI3f9y+vnPgl8+fW2FY	false	sufficient binding region:308-670	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28652	uniprotkb:P11798-2	intact:EBI-397029|uniprotkb:Q5SVH9|ensembl:ENSMUSP00000105438|ensembl:ENSMUSP00000105440	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:kcc2b_mouse(display_long)|uniprotkb:Camk2b(gene name)|psi-mi:Camk2b(display_short)|uniprotkb:Camk2d(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652682	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031621.3|ensembl:ENSMUSG00000057897(gene)|ensembl:ENSMUST00000109813(transcript)|ensembl:ENSMUST00000109815(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005954"(calcium- and calmodulin-dependent protein kinase complex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030425"(dendrite)|go:"GO:0032222"(regulation of synaptic transmission, cholinergic)|go:"GO:0032430"(positive regulation of phospholipase A2 activity)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0002030"(inhibitory G protein-coupled receptor phosphorylation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0046686"(response to cadmium ion)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048169"(regulation of long-term neuronal synaptic plasticity)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051233"(spindle midzone)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060466"(activation of meiosis involved in egg activation)|reactome:R-MMU-438066|reactome:R-MMU-5576892|reactome:R-MMU-5578775|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-877300|reactome:R-MMU-936837|go:"GO:0090129"(positive regulation of synapse maturation)|go:"GO:0098973"(structural constituent of postsynaptic actin cytoskeleton)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:2001222"(regulation of neuron migration)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR013543(Calcium/calmodulin dependent protein kinase II, association-domain)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR032710|mint:P28652|reactome:R-MMU-3371571|reactome:R-MMU-399719|go:"GO:0061003"(positive regulation of dendritic spine morphogenesis)|dip:DIP-31582N	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:13970(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:di/l1bhtPhzeKpErP6iyQfFypBo10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:99DBCE87BB227289|rigid:PoTRDU+6xxjGnp32SL74L0M4JWU	false	sufficient binding region:437-526	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11798-2	uniprotkb:P70168	intact:EBI-400402|ensembl:ENSMUSP00000110950	intact:EBI-540580|uniprotkb:Q62117|uniprotkb:Q6GTI5|ensembl:ENSMUSP00000001479	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:imb1_mouse(display_long)|uniprotkb:Karyopherin subunit beta-1(gene name synonym)|uniprotkb:Nuclear factor p97(gene name synonym)|uniprotkb:Pore targeting complex 97 kDa subunit(gene name synonym)|uniprotkb:SCG(gene name synonym)|uniprotkb:Kpnb1(gene name)|psi-mi:Kpnb1(display_short)|uniprotkb:Impnb(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652692	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	refseq:NP_032405.3|ensembl:ENSMUSG00000001440(gene)|ensembl:ENSMUST00000001479(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0007079"(mitotic chromosome movement towards spindle pole)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010494"(cytoplasmic stress granule)|reactome:R-MMU-2995383|reactome:R-MMU-6798695|reactome:R-MMU-909733|reactome:R-MMU-1655829|go:"GO:0019899"(enzyme binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031291"(Ran protein signal transduction)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032991"(protein-containing complex)|go:"GO:0040001"(establishment of mitotic spindle localization)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0061676"(importin-alpha family protein binding)|go:"GO:0071782"(endoplasmic reticulum tubular network)|go:"GO:0090307"(mitotic spindle assembly)|interpro:IPR000225(Armadillo)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR021133|interpro:IPR040122|mint:P70168|rcsb pdb:1GCJ|rcsb pdb:1UKL|go:"GO:0019894"(kinesin binding)|reactome:R-MMU-140342|dip:DIP-33404N	afcs:15755(primary-reference)|afcs:14635(secondary-ac)	isoform-comment:Has no kinase activity.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	rogid:rYDCcZYUZp8TbcpyJE7pfz5+bvo10090	intact-crc:790A84ECA4EB25C4|rigid:Rr95d1dDerRA/kYsz2CjiGFvQvs	false	sufficient binding region:13-110	sufficient binding region:383-567	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JKF1	uniprotkb:P11798-2	intact:EBI-644633|ensembl:ENSMUSP00000128278|uniprotkb:G3UW45	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:iqga1_mouse(display_long)|uniprotkb:Iqgap1(gene name)|psi-mi:Iqgap1(display_short)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652702	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051019"(mitogen-activated protein kinase binding)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0072015"(glomerular visceral epithelial cell development)|go:"GO:1900006"(positive regulation of dendrite development)|go:"GO:1900086"(positive regulation of peptidyl-tyrosine autophosphorylation)|go:"GO:1903829"(positive regulation of protein localization)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990776"(response to angiotensin)|ensembl:ENSMUSG00000030536(gene)|ensembl:ENSMUST00000167377(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0005078"(MAP-kinase scaffold activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007346"(regulation of mitotic cell cycle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0010761"(fibroblast migration)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0030496"(midbody)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035305"(negative regulation of dephosphorylation)|go:"GO:0036057"(slit diaphragm)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0043005"(neuron projection)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043406"(positive regulation of MAP kinase activity)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043539"(protein serine/threonine kinase activator activity)|go:"GO:0044344"(cellular response to fibroblast growth factor stimulus)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0031252"(cell leading edge)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000593(RasGAP protein, C-terminal)|interpro:IPR001202(WW/Rsp5/WWP)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001936(Ras GTPase-activating protein)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR023152|interpro:IPR027417|interpro:IPR036872|mint:Q9JKF1|reactome:R-MMU-373753|reactome:R-MMU-5626467|reactome:R-MMU-5674135|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013106|reactome:R-MMU-9013148|go:"GO:1990904"(ribonucleoprotein complex)|reactome:R-MMU-9013149|refseq:NP_057930.2|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:17695(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qjWT+er4GkLOlebk3zzRHh2Iqoo10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:4AB59DF06EB60F36|rigid:xQMONGRqIaezZEhrd7jQRdMJ5UE	false	sufficient binding region:1089-1230	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54737	uniprotkb:P11798-2	intact:EBI-641814	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:o54737_mouse(display_long)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:BCA(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652712	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000980(SH2 motif)|interpro:IPR036860	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:21969(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1zp5CTiuW80CRlnp2JGf/SHMJao10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:02C6982F420145E2|rigid:eFcHepB9PSpdtRgpejStBVp0KuM	false	sufficient binding region:222-381	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1R2	uniprotkb:P11798-2	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652722	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:15755(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:1CF0F10B534684AF|rigid:SBUP1q9RC3HiF96DJjgOznKEmKM	false	sufficient binding region:740-1007	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1R2	uniprotkb:P11798-2	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652732	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:15755(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:D8A7F5DD2FFB432A|rigid:SBUP1q9RC3HiF96DJjgOznKEmKM	false	sufficient binding region:754-1135	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1R2	uniprotkb:P11798-2	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652742	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:15755(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:58884CA32A626B6D|rigid:SBUP1q9RC3HiF96DJjgOznKEmKM	false	sufficient binding region:958-1154	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CBW3	uniprotkb:P11798-2	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652752	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:33872(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:3EDF7F5B39440769|rigid:6EGJw/7CggiJ18vwiSnDgnNGLdk	false	sufficient binding region:328-475	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VE62	uniprotkb:P11798-2	intact:EBI-644652|uniprotkb:Q9WUC9|ensembl:ENSMUSP00000026520	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:paip1_mouse(display_long)|uniprotkb:Paip1(gene name)|psi-mi:Paip1(display_short)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652762	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_663432.1|go:"GO:0003723"(RNA binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0008494"(translation activator activity)|interpro:IPR003890(MIF4G-like, type 3)|interpro:IPR009818(Ataxin-2, C-terminal)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR016024(Armadillo-type fold)|mint:Q8VE62|reactome:R-MMU-429947|ensembl:ENSMUST00000026520(transcript)|ensembl:ENSMUSG00000025451(gene)	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:40007(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:tDITLD/6QA23wivFTI1YO9W/zV010090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:B2B66E44152EA516|rigid:TKoSrY+EkDehBkgnlZdZzhL8d38	false	sufficient binding region:237-359	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6NXH3	uniprotkb:P11798-2	intact:EBI-644659|uniprotkb:Q3TQR2|uniprotkb:Q3TSN7|uniprotkb:Q6TYE7|uniprotkb:Q8C498|uniprotkb:Q8R252|ensembl:ENSMUSP00000088777	intact:EBI-400402|ensembl:ENSMUSP00000110950	psi-mi:gpbp1_mouse(display_long)|uniprotkb:Gpbp(gene name synonym)|uniprotkb:GC-rich promoter-binding protein 1(gene name synonym)|uniprotkb:Gpbp1(gene name)|psi-mi:Gpbp1(display_short)	psi-mi:p11798-2(display_long)|uniprotkb:Camk2a(gene name)|psi-mi:Camk2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652772	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_017171102.1|refseq:XP_017171103.1|refseq:NP_001116435.1|refseq:NP_082763.3|refseq:XP_006517835.1|refseq:XP_006517836.1|ensembl:ENSMUSG00000032745(gene)|ensembl:ENSMUST00000091236(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR028128	intact:EBI-400384(kcc2a_mouse)|ensembl:ENSMUSG00000024617(gene)|ensembl:ENSMUST00000115295(transcript)	afcs:15755(primary-reference)|afcs:40009(secondary-ac)	-	isoform-comment:Has no kinase activity.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:XtTw4YNebc6PhRqulgx80t08tFM10090	rogid:KYFQg9ilfaVmeWtiife76nz3Iig10090	intact-crc:570A9AD89190C23A|rigid:d9EM1ZRHaCoRpTSAp745BRX/XGI	false	sufficient binding region:361-473	sufficient binding region:13-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3UYC8	uniprotkb:Q8R3Z5	intact:EBI-686201	intact:EBI-644833|uniprotkb:O88517|uniprotkb:Q7TPF2|uniprotkb:Q8R3Z6|uniprotkb:Q9EPT9|uniprotkb:A2A544	psi-mi:q3uyc8_mouse(display_long)|uniprotkb:Adnp(gene name)|psi-mi:Adnp(display_short)	psi-mi:cacb1_mouse(display_long)|uniprotkb:Calcium channel voltage-dependent subunit beta 1(gene name synonym)|uniprotkb:Cacnb1(gene name)|psi-mi:Cacnb1(display_short)|uniprotkb:Cacnlb1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688301	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|refseq:NP_001297015.1|refseq:NP_001297017.1|refseq:NP_033758.2|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR038861|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)	refseq:NP_001152791.1|refseq:NP_112450.1|interpro:IPR008145(Guanylate kinase/L-type calcium channel region)|interpro:IPR001452(Src homology-3)|interpro:IPR005443(Voltage-dependent calcium channel, L-type, beta-1 subunit)|interpro:IPR000584(Voltage-dependent calcium channel, L-type, beta subunit)|interpro:IPR027417|rcsb pdb:4ZW2|go:"GO:0030315"(T-tubule)|go:"GO:1901385"(regulation of voltage-gated calcium channel activity)|go:"GO:1902514"(regulation of calcium ion transmembrane transport via high voltage-gated calcium channel)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:0098793"(presynapse)|reactome:R-MMU-5576892|reactome:R-MMU-5576893|reactome:R-MMU-112308|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0005891"(voltage-gated calcium channel complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008331"(high voltage-gated calcium channel activity)|go:"GO:0016529"(sarcoplasmic reticulum)|interpro:IPR036028	afcs:40008(secondary-ac)|afcs:33470(primary-reference)|afcs:40008(primary-reference)	comment:AfCS Y2H protein 40008. Translated from nucleotide sequence.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:27mnGD1oAiIoyfnv6Yfh+EhcUuI10090	rogid:e7XKbBMDfWDxQMlMoCmj8zyECCI10090	intact-crc:91709F45691C5BDB|rigid:CDpLlD4x41uVuUQkThYpeM2SB9Y	false	sufficient binding region:68-198	sufficient binding region:1-180	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P68040	uniprotkb:O88351	intact:EBI-296749|ensembl:ENSMUSP00000020640|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-1183965|uniprotkb:Q3THP0|uniprotkb:Q3THY7|uniprotkb:Q3TKQ0|uniprotkb:Q3TW88|uniprotkb:Q5NCC5|uniprotkb:Q5NCC6|uniprotkb:Q9CSQ0|uniprotkb:Q9ERM6	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:rack1_mouse(display_long)|uniprotkb:p205(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:12-3(gene name synonym)|uniprotkb:Gnb2-rs1(gene name synonym)|uniprotkb:Gnb2l1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655728	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P68040|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|go:"GO:0072344"(rescue of stalled ribosome)|ensembl:ENSMUSG00000020372(gene)|ensembl:ENSMUST00000020640(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0006412"(translation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|refseq:NP_032169.1	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:14441(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:4C55078B8A23D8B0|rigid:mBT8Z1z8uu7hetnSaKOmcFuXQWg	false	sufficient binding region:180-317	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P68040	uniprotkb:O88351	intact:EBI-296749|ensembl:ENSMUSP00000020640|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-1183965|uniprotkb:Q3THP0|uniprotkb:Q3THY7|uniprotkb:Q3TKQ0|uniprotkb:Q3TW88|uniprotkb:Q5NCC5|uniprotkb:Q5NCC6|uniprotkb:Q9CSQ0|uniprotkb:Q9ERM6	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:rack1_mouse(display_long)|uniprotkb:p205(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:12-3(gene name synonym)|uniprotkb:Gnb2-rs1(gene name synonym)|uniprotkb:Gnb2l1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655748	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P68040|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|go:"GO:0072344"(rescue of stalled ribosome)|ensembl:ENSMUSG00000020372(gene)|ensembl:ENSMUST00000020640(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0006412"(translation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|refseq:NP_032169.1	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:14441(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:1CAE89A79D6568D4|rigid:mBT8Z1z8uu7hetnSaKOmcFuXQWg	false	sufficient binding region:194-317	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P15105	uniprotkb:P35991	intact:EBI-444858|uniprotkb:Q3TRK7|uniprotkb:Q64432|uniprotkb:Q91VC6|ensembl:ENSMUSP00000083375|ensembl:ENSMUSP00000123157	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:glna_mouse(display_long)|uniprotkb:Glutamate--ammonia ligase(gene name synonym)|uniprotkb:Glul(gene name)|psi-mi:Glul(display_short)|uniprotkb:Glns(gene name synonym)|uniprotkb:Palmitoyltransferase GLUL(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650931	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032157.2|go:"GO:0030145"(manganese ion binding)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042254"(ribosome biogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043679"(axon terminus)|go:"GO:0044297"(cell body)|go:"GO:0045503"(dynein light chain binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051968"(positive regulation of synaptic transmission, glutamatergic)|go:"GO:0097386"(glial cell projection)|go:"GO:1903670"(regulation of sprouting angiogenesis)|go:"GO:1904749"(regulation of protein localization to nucleolus)|interpro:IPR008146(Glutamine synthetase, catalytic region)|interpro:IPR008147(Glutamine synthetase, beta-Grasp)|interpro:IPR014746(Glutamine synthetase/guanido kinase, catalytic region)|interpro:IPR027302|interpro:IPR027303|interpro:IPR036651|mint:P15105|reactome:R-MMU-210455|reactome:R-MMU-8964539|go:"GO:0019706"(protein-cysteine S-palmitoyltransferase activity)|ensembl:ENSMUSG00000026473(gene)|ensembl:ENSMUST00000086199(transcript)|ensembl:ENSMUST00000140685(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001525"(angiogenesis)|go:"GO:0004356"(glutamate-ammonia ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006536"(glutamate metabolic process)|go:"GO:0006542"(glutamine biosynthetic process)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0016595"(glutamate binding)|go:"GO:0018345"(protein palmitoylation)|go:"GO:0019676"(ammonia assimilation cycle)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:14431(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:j6R9fxGLKpiREWpecpdnBY9ftoo10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:56A823C083711C45|rigid:ydUpuo8y8jS2jEdGOb/bhJQzESc	false	sufficient binding region:146-340	sufficient binding region:210-280	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JK42	uniprotkb:E9PZQ0	intact:EBI-643530|uniprotkb:Q8VC63|ensembl:ENSMUSP00000041447	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:pdk2_mouse(display_long)|uniprotkb:Pyruvate dehydrogenase kinase isoform 2(gene name synonym)|uniprotkb:Pdk2(gene name)|psi-mi:Pdk2(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651222	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598428.2|ensembl:ENSMUSG00000038967(gene)|ensembl:ENSMUST00000038431(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004740"("pyruvate dehydrogenase (acetyl-transferring) kinase activity")|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005967"(mitochondrial pyruvate dehydrogenase complex)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006885"(regulation of pH)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010510"(regulation of acetyl-CoA biosynthetic process from pyruvate)|go:"GO:0010565"(regulation of cellular ketone metabolic process)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0031670"(cellular response to nutrient)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045254"(pyruvate dehydrogenase complex)|go:"GO:0050848"(regulation of calcium-mediated signaling)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|interpro:IPR003594(ATP-binding region, ATPase-like)|interpro:IPR018955|interpro:IPR036784|interpro:IPR036890|interpro:IPR039028|mint:Q9JK42|reactome:R-MMU-204174|reactome:R-MMU-5362517|interpro:IPR005467(Signal transduction histidine kinase, core)	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34667(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	caution:The prey construct contains 5 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:D23zOk9wYjzMwMQYSgquxlE6XVc10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:DB9E0A0229D04885|rigid:pnFWR70J0K5pRcB6HOvkdptlSiQ	false	sufficient binding region:1-190	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03172	uniprotkb:P63085	intact:EBI-646850	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:zep1_mouse(display_long)|uniprotkb:Transcription factor alphaA-CRYBP1(gene name synonym)|uniprotkb:Alpha A-crystallin-binding protein I(gene name synonym)|uniprotkb:Alpha A-crystallin-binding protein 1(gene name synonym)|uniprotkb:Hivep1(gene name)|psi-mi:Hivep1(display_short)|uniprotkb:Cryabp1(gene name synonym)|uniprotkb:Znf40(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657474	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR034729|interpro:IPR036236|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:14118(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2aZZR3UcsEIiv2Hn0nBPw4ih2F010090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:15E99C8122E9C9EF|rigid:zmW3Wv69nOvYYwKxQTDjKSsjdHk	false	sufficient binding region:1347-1446	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08863	uniprotkb:P39429	intact:EBI-642236|uniprotkb:E9QLX3	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:birc3_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:Birc3(gene name)|psi-mi:Birc3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658343	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031490.2|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|mint:O08863|dip:DIP-43742N	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:13827(secondary-ac)	-	-	caution:The prey construct contains 35 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rPZRfzbIHpwQop1BRwyZl+TfhUg10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:07A33F2D82A99AC9|rigid:wHeVbAt+bLLgWVL8zorSZQCspSo	false	sufficient binding region:1-160	sufficient binding region:143-343	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08863	uniprotkb:P39429	intact:EBI-642236|uniprotkb:E9QLX3	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:birc3_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:Birc3(gene name)|psi-mi:Birc3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658364	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031490.2|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|mint:O08863|dip:DIP-43742N	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:13827(secondary-ac)	-	-	caution:The prey construct contains 26 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rPZRfzbIHpwQop1BRwyZl+TfhUg10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:9FD940489C63284D|rigid:wHeVbAt+bLLgWVL8zorSZQCspSo	false	sufficient binding region:1-161	sufficient binding region:143-343	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08863	uniprotkb:P39429	intact:EBI-642236|uniprotkb:E9QLX3	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:birc3_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:Birc3(gene name)|psi-mi:Birc3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658374	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031490.2|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|mint:O08863|dip:DIP-43742N	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:13827(secondary-ac)	-	-	caution:The prey construct contains 20 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rPZRfzbIHpwQop1BRwyZl+TfhUg10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:315D3D74905021A6|rigid:wHeVbAt+bLLgWVL8zorSZQCspSo	false	sufficient binding region:1-178	sufficient binding region:143-343	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08863	uniprotkb:P39429	intact:EBI-642236|uniprotkb:E9QLX3	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:birc3_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:Birc3(gene name)|psi-mi:Birc3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658395	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031490.2|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|mint:O08863|dip:DIP-43742N	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:13827(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rPZRfzbIHpwQop1BRwyZl+TfhUg10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:68C5706E6B46C2D8|rigid:wHeVbAt+bLLgWVL8zorSZQCspSo	false	sufficient binding region:16-325	sufficient binding region:143-343	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26231	uniprotkb:O88351	intact:EBI-647895|ensembl:ENSMUSP00000049007	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:ctna1_mouse(display_long)|uniprotkb:102 kDa cadherin-associated protein(gene name synonym)|uniprotkb:CAP102(gene name synonym)|uniprotkb:Alpha E-catenin(gene name synonym)|uniprotkb:Ctnna1(gene name)|psi-mi:Ctnna1(display_short)|uniprotkb:Catna1(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658983	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033948.1|refseq:XP_011245120.1|dip:DIP-35299N|ensembl:ENSMUSG00000037815(gene)|ensembl:ENSMUST00000042345(transcript)|go:"GO:0001541"(ovarian follicle development)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005915"(zonula adherens)|go:"GO:0007015"(actin filament organization)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007406"(negative regulation of neuroblast proliferation)|go:"GO:0007568"(aging)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008584"(male gonad development)|go:"GO:0014704"(intercalated disc)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016264"(gap junction assembly)|go:"GO:0016342"(catenin complex)|go:"GO:0016477"(cell migration)|go:"GO:0016600"(flotillin complex)|go:"GO:0017166"(vinculin binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0031103"(axon regeneration)|go:"GO:0034613"(cellular protein localization)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043297"(apical junction assembly)|go:"GO:0043627"(response to estrogen)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045880"(positive regulation of smoothened signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2001045"(negative regulation of integrin-mediated signaling pathway)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:2001241"(positive regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000633(Vinculin, conserved site)|interpro:IPR001033(Alpha-catenin)|interpro:IPR006077(Vinculin/alpha-catenin)|interpro:IPR030047|interpro:IPR036723|mint:P26231|rcsb pdb:1DOV|rcsb pdb:1DOW|rcsb pdb:1L7C|rcsb pdb:4E17|rcsb pdb:4E18|rcsb pdb:4K1N|rcsb pdb:5Y04|rcsb pdb:6DV1|rcsb pdb:6O3E|rcsb pdb:6WVT|reactome:R-MMU-418990|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:15772(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2GScCoVKWPHfjBJE6Gm6yVmO/IA10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:0A398497FAA37C81|rigid:7Xxz8vb84HxlyWKdncxkJTsibag	false	sufficient binding region:661-906	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01768	uniprotkb:P09055	intact:EBI-642573|ensembl:ENSMUSP00000021217|ensembl:ENSMUSP00000103476	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:ndkb_mouse(display_long)|uniprotkb:nm23-M2(gene name synonym)|uniprotkb:P18(gene name synonym)|uniprotkb:Nme2(gene name)|psi-mi:Nme2(display_short)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651871	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070997.1|refseq:NP_032731.1|ensembl:ENSMUSG00000020857(gene)|ensembl:ENSMUST00000021217(transcript)|ensembl:ENSMUST00000072566(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1901363"(heterocyclic compound binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q01768|reactome:R-MMU-499943|reactome:R-MMU-6798695	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:7069(secondary-ac)|afcs:18892(primary-reference)	-	-	caution:The prey construct contains 6 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AJ1Depmyy9zwTEUOZMRO7TKPd1k10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:44B6A1BFAD3020E9|rigid:F9EmQdXxnmQWKy4XeMPJRepbQNY	false	sufficient binding region:1-152	sufficient binding region:750-798	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01768	uniprotkb:P09055	intact:EBI-642573|ensembl:ENSMUSP00000021217|ensembl:ENSMUSP00000103476	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:ndkb_mouse(display_long)|uniprotkb:nm23-M2(gene name synonym)|uniprotkb:P18(gene name synonym)|uniprotkb:Nme2(gene name)|psi-mi:Nme2(display_short)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651881	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070997.1|refseq:NP_032731.1|ensembl:ENSMUSG00000020857(gene)|ensembl:ENSMUST00000021217(transcript)|ensembl:ENSMUST00000072566(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1901363"(heterocyclic compound binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q01768|reactome:R-MMU-499943|reactome:R-MMU-6798695	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:18892(primary-reference)|afcs:7069(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AJ1Depmyy9zwTEUOZMRO7TKPd1k10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:6171BD78FE62E6F9|rigid:F9EmQdXxnmQWKy4XeMPJRepbQNY	false	sufficient binding region:28-152	sufficient binding region:750-798	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYE6	uniprotkb:Q99N72	intact:EBI-644242|uniprotkb:O88317|uniprotkb:Q3TGE7|uniprotkb:Q3U6S5|uniprotkb:Q3UUF9|ensembl:ENSMUSP00000021609|ensembl:ENSMUSP00000137305	intact:EBI-641874	psi-mi:goga5_mouse(display_long)|uniprotkb:Golgin-84(gene name synonym)|uniprotkb:Protein Sumiko(gene name synonym)|uniprotkb:Protein Ret-II(gene name synonym)|uniprotkb:Golga5(gene name)|psi-mi:Golga5(display_short)|uniprotkb:Retii(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651902	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185933.1|refseq:NP_038775.1|refseq:XP_006515998.1|ensembl:ENSMUSG00000021192(gene)|ensembl:ENSMUST00000021609(transcript)|ensembl:ENSMUST00000179218(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000301"(retrograde transport, vesicle recycling within Golgi)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR019177	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:17417(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c7FH+gQxrIBgwdT419J+D6i+fKg10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:D7F2FD88EE2B8606|rigid:8FZWbuVBt9CNAjJSgJ8jfsiUYgA	false	sufficient binding region:372-576	sufficient binding region:5-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D721	uniprotkb:Q99N72	intact:EBI-644250|ensembl:ENSMUSP00000141678	intact:EBI-641874	psi-mi:q9d721_mouse(display_long)|uniprotkb:Wdr20(gene name)|psi-mi:Wdr20(display_short)|uniprotkb:Wdr20a(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651922	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR015943(WD40/YVTN repeat-like)|ensembl:ENSMUSG00000037957(gene)|ensembl:ENSMUST00000193053(transcript)|refseq:NP_001334357.1	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:30556(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/8+Y/pTM8TlSEXgD0b1Q2TEzHww10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:90D03CB523D2481D|rigid:VywGY7Ntw4Zj7lKkAR/MkkU0c4I	false	sufficient binding region:84-144	sufficient binding region:5-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CIE6	uniprotkb:Q99N72	intact:EBI-644254|uniprotkb:E9Q075|ensembl:ENSMUSP00000118179	intact:EBI-641874	psi-mi:copa_mouse(display_long)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:Copa(gene name)|psi-mi:Copa(display_short)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651932	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034068.3|ensembl:ENSMUSG00000026553(gene)|ensembl:ENSMUST00000135192(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003729"(mRNA binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0044297"(cell body)|go:"GO:0099612"(protein localization to axon)|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:Q8CIE6|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-MMU-6807878|reactome:R-MMU-6811434	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:35805(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c+/zgZ1/6rEy0vlikp+E+4gijto10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:BD16762A2CA2837A|rigid:54isF7ddyUYOE8CGUbF7V9v+Xos	false	sufficient binding region:766-1224	sufficient binding region:5-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CIE6	uniprotkb:Q99N72	intact:EBI-644254|uniprotkb:E9Q075|ensembl:ENSMUSP00000118179	intact:EBI-641874	psi-mi:copa_mouse(display_long)|uniprotkb:Alpha-coat protein(gene name synonym)|uniprotkb:Copa(gene name)|psi-mi:Copa(display_short)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651942	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034068.3|ensembl:ENSMUSG00000026553(gene)|ensembl:ENSMUST00000135192(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003729"(mRNA binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006890"(retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0030157"(pancreatic juice secretion)|go:"GO:0030424"(axon)|go:"GO:0030426"(growth cone)|go:"GO:0044297"(cell body)|go:"GO:0099612"(protein localization to axon)|go:"GO:1902463"(protein localization to cell leading edge)|interpro:IPR001680(WD40 repeat)|interpro:IPR006692(Coatomer, WD associated region)|interpro:IPR010714(Coatomer, alpha subunit, C-terminal)|interpro:IPR011048(Cytochrome cd1-nitrite reductase-like, C-terminal haem d1)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR016391(Coatomer, alpha subunit)|interpro:IPR019775|interpro:IPR020472|interpro:IPR024977|interpro:IPR036322|mint:Q8CIE6|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-MMU-6807878|reactome:R-MMU-6811434	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:35805(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c+/zgZ1/6rEy0vlikp+E+4gijto10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:ACAFBBBFA734D3CC|rigid:54isF7ddyUYOE8CGUbF7V9v+Xos	false	sufficient binding region:880-1224	sufficient binding region:5-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61193	uniprotkb:P32883-2	intact:EBI-644290|uniprotkb:Q9QUJ2|ensembl:ENSMUSP00000041082	intact:EBI-644285|uniprotkb:P08643-1|ensembl:ENSMUSP00000032399	psi-mi:rgl2_mouse(display_long)|uniprotkb:RalGDS-like factor(gene name synonym)|uniprotkb:Ras-associated protein RAB2L(gene name synonym)|uniprotkb:Rgl2(gene name)|psi-mi:Rgl2(display_short)|uniprotkb:Rab2l(gene name synonym)|uniprotkb:Rlf(gene name synonym)	psi-mi:p32883-2(display_long)|uniprotkb:Kras(gene name)|psi-mi:Kras(display_short)|uniprotkb:Kras2(gene name synonym)|uniprotkb:K-Ras 2(gene name synonym)|uniprotkb:Ki-Ras(gene name synonym)|uniprotkb:c-K-ras(gene name synonym)|uniprotkb:c-Ki-ras(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651952	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033085.2|ensembl:ENSMUSG00000041354(gene)|ensembl:ENSMUST00000047503(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0032485"(regulation of Ral protein signal transduction)|interpro:IPR000159(Ras-association)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR030749|interpro:IPR036964|rcsb pdb:1RLF|rcsb pdb:4JGW|rcsb pdb:5CM8|rcsb pdb:5CM9|reactome:R-MMU-5673001	intact:EBI-644267(rask_mouse)|ensembl:ENSMUSG00000030265(gene)|ensembl:ENSMUST00000032399(transcript)	afcs:34274(primary-reference)|afcs:6853(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:nzMfBum+YeniQUocbEauEEzbniU10090	rogid:QQ2jCFyfJfOiwuQ4vrh9ZZ0C0y810090	intact-crc:A496F5266F48EEB9|rigid:GDYwd7dTR0cAjk6jTpyrsA6HKbk	false	sufficient binding region:535-778	sufficient binding region:1-188	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61990-3	uniprotkb:P26450	intact:EBI-644319|ensembl:ENSMUSP00000155038	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:q61990-3(display_long)|uniprotkb:Pcbp2(gene name)|psi-mi:Pcbp2(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Hnrnpx(gene name synonym)|uniprotkb:Hnrpx(gene name synonym)|uniprotkb:Alpha-CP2(gene name synonym)|uniprotkb:CTBP(gene name synonym)|uniprotkb:Putative heterogeneous nuclear ribonucleoprotein X(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651963	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644300(pcbp2_mouse)|ensembl:ENSMUSG00000056851(gene)|ensembl:ENSMUST00000229854(transcript)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:16529(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ftlytBPsLOIoqxkyc1Cgn6D8MDI10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:A0ADB32CD5948976|rigid:qLLbf5arn4CDPaU56TOSpkTVxw4	false	sufficient binding region:106-168	sufficient binding region:1-251	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01768	uniprotkb:P26450	intact:EBI-642573|ensembl:ENSMUSP00000021217|ensembl:ENSMUSP00000103476	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:ndkb_mouse(display_long)|uniprotkb:nm23-M2(gene name synonym)|uniprotkb:P18(gene name synonym)|uniprotkb:Nme2(gene name)|psi-mi:Nme2(display_short)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651974	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070997.1|refseq:NP_032731.1|ensembl:ENSMUSG00000020857(gene)|ensembl:ENSMUST00000021217(transcript)|ensembl:ENSMUST00000072566(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1901363"(heterocyclic compound binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q01768|reactome:R-MMU-499943|reactome:R-MMU-6798695	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:7069(secondary-ac)|afcs:52679(primary-reference)	-	-	caution:The prey construct contains 6 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AJ1Depmyy9zwTEUOZMRO7TKPd1k10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:31A81EC9A96F57C9|rigid:OuB3NSY9PWfFsZmsVA71U0L76js	false	sufficient binding region:1-152	sufficient binding region:1-251	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6ZQG6	uniprotkb:Q99M51	intact:EBI-644323	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:q6zqg6_mouse(display_long)|uniprotkb:Plagl2(gene name)|psi-mi:Plagl2(display_short)|uniprotkb:mKIAA0198(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651993	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0009791"(post-embryonic development)|go:"GO:0034378"(chylomicron assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR036236|interpro:IPR027765	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:7461(primary-reference)|afcs:17971(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:HASHp3bb1vFILHKygbql1lZoko810090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:462BB9E5F10D736C|rigid:jd4V4T4NoMXs5cz2XPGyXwjpFfY	false	sufficient binding region:87-131	sufficient binding region:1-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0P7	uniprotkb:Q99M51	intact:EBI-644332|uniprotkb:Q8K4L8|uniprotkb:Q9QXY5|ensembl:ENSMUSP00000088049|ensembl:ENSMUSP00000099689	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:psrc1_mouse(display_long)|uniprotkb:Psrc1(gene name)|psi-mi:Psrc1(display_short)|uniprotkb:Dda3(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652004	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001177090.1|refseq:NP_064360.1|ensembl:ENSMUSG00000068744(gene)|ensembl:ENSMUST00000090561(transcript)|ensembl:ENSMUST00000102629(transcript)|go:"GO:0000922"(spindle pole)|go:"GO:0001578"(microtubule bundle formation)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005876"(spindle microtubule)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0008017"(microtubule binding)|go:"GO:0009987"(cellular process)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0045737"(positive regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0051301"(cell division)|go:"GO:0060236"(regulation of mitotic spindle organization)|interpro:IPR026657|interpro:IPR026658|interpro:IPR032768|go:"GO:0030496"(midbody)	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:7461(primary-reference)|afcs:18409(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:OADLF9LvMF3nNAAWqmAEph8HeKs10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:34289429FF98EF6B|rigid:Pu225vTfAIitjGMRhx2+EFppLuc	false	sufficient binding region:125-329	sufficient binding region:1-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P14211	uniprotkb:Q99M51	intact:EBI-644340|ensembl:ENSMUSP00000003912|uniprotkb:Q3TVD2	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:calr_mouse(display_long)|uniprotkb:CRP55(gene name synonym)|uniprotkb:Calregulin(gene name synonym)|uniprotkb:HACBP(gene name synonym)|uniprotkb:Endoplasmic reticulum resident protein 60(gene name synonym)|uniprotkb:Calr(gene name)|psi-mi:Calr(display_short)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652014	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031617.1|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030246"(carbohydrate binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0030968"(endoplasmic reticulum unfolded protein response)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033018"(sarcoplasmic reticulum lumen)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033574"(response to testosterone)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0006457"(protein folding)|go:"GO:0040020"(regulation of meiotic nuclear division)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0042277"(peptide binding)|go:"GO:0042493"|go:"GO:0042562"(hormone binding)|go:"GO:0042824"(MHC class I peptide loading complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0007283"(spermatogenesis)|go:"GO:0060473"(cortical granule)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0071285"(cellular response to lithium ion)|go:"GO:0090398"(cellular senescence)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:2000510"(positive regulation of dendritic cell chemotaxis)|interpro:IPR001580(Calreticulin/calnexin)|interpro:IPR009033(Calreticulin/calnexin, P)|interpro:IPR009169(Calreticulin)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|go:"GO:0008284"(positive regulation of cell population proliferation)|interpro:IPR018124|mint:P14211|rcsb pdb:3O0V|rcsb pdb:3O0W|rcsb pdb:3O0X|rcsb pdb:3RG0|go:"GO:0009897"(external side of plasma membrane)|reactome:R-MMU-1236974|reactome:R-MMU-3000480|reactome:R-MMU-901042|go:"GO:0009986"(cell surface)|go:"GO:0010595"(positive regulation of endothelial cell migration)|ensembl:ENSMUSG00000003814(gene)|ensembl:ENSMUST00000003912(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0002502"(peptide antigen assembly with MHC class I protein complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005506"(iron ion binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|reactome:R-MMU-983170	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:7461(primary-reference)|afcs:13967(secondary-ac)	-	-	caution:The prey construct contains 16 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/yN2nHI8x9rWoJO+b+2dYGxOgf010090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:A27C9149E0CE2BD5|rigid:PJ5TyOISBvdmvVW1wHVkbMHXzmA	false	sufficient binding region:1-223	sufficient binding region:1-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63001	uniprotkb:P60766	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	intact:EBI-81763|ensembl:ENSMUSP00000054634|uniprotkb:A2A9U6|uniprotkb:P21181|uniprotkb:P25763|uniprotkb:Q3THZ7|uniprotkb:Q3TJK6|uniprotkb:Q545V0|uniprotkb:Q6P201|uniprotkb:Q8BQ51	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:cdc42_mouse(display_long)|uniprotkb:Cdc42(gene name)|psi-mi:Cdc42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651456	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	ensembl:ENSMUSG00000006699(gene)|ensembl:ENSMUST00000051477(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000322"(storage vacuole)|go:"GO:0002040"(sprouting angiogenesis)|go:"GO:0003161"(cardiac conduction system development)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007015"(actin filament organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0007088"(regulation of mitotic nuclear division)|refseq:NP_033991.1|go:"GO:0007097"(nuclear migration)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016020"(membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0016477"(cell migration)|go:"GO:0017119"(Golgi transport complex)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030141"(secretory granule)|go:"GO:0030175"(filopodium)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030496"(midbody)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0031256"(leading edge membrane)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0031274"(positive regulation of pseudopodium assembly)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032427"(GBD domain binding)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0034191"(apolipoprotein A-I receptor binding)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036336"(dendritic cell migration)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0038189"(neuropilin signaling pathway)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0043209"(myelin sheath)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0045177"(apical part of cell)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048549"(positive regulation of pinocytosis)|go:"GO:0051233"(spindle midzone)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051647"(nucleus localization)|go:"GO:0051683"(establishment of Golgi localization)|go:"GO:0051835"(positive regulation of synapse structural plasticity)|go:"GO:0051988"(regulation of attachment of spindle microtubules to kinetochore)|go:"GO:0060047"(heart contraction)|go:"GO:0060501"(positive regulation of epithelial cell proliferation involved in lung morphogenesis)|go:"GO:0060661"(submandibular salivary gland formation)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0071944"(cell periphery)|go:"GO:0072384"(organelle transport along microtubule)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090135"(actin filament branching)|go:"GO:0090316"(positive regulation of intracellular protein transport)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0099159"(regulation of modification of postsynaptic structure)|go:"GO:0099563"(modification of synaptic structure)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|interpro:IPR037874|mint:P60766|rcsb pdb:3EG5|rcsb pdb:5C2J|reactome:R-MMU-114604|reactome:R-MMU-182971|reactome:R-MMU-2029482|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-525793|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|reactome:R-MMU-5663213|reactome:R-MMU-5663220|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-983231|go:"GO:0048664"(neuron fate determination)|refseq:NP_001230698.1|dip:DIP-32554N	afcs:15804(primary-reference)|afcs:23265(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU10090	intact-crc:5263604F61A73A23|rigid:2ntPcmR4LbFSduJMwAK9BiF+gcU	false	sufficient binding region:73-192	sufficient binding region:1-100	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:O08908	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651592	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:B2F6C6C52D094DE4|rigid:1FBhY6eBXGI3TUXgmerzWs1aXe0	false	sufficient binding region:428-651	sufficient binding region:397-624	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9EQ32	uniprotkb:Q99M51	intact:EBI-643949|uniprotkb:Q2KHL6|uniprotkb:Q3TBW6|uniprotkb:Q3TC39|uniprotkb:Q3U5J3|uniprotkb:Q8BN25|uniprotkb:Q8C2Y4|ensembl:ENSMUSP00000052777	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:bcap_mouse(display_long)|uniprotkb:Bcap(gene name synonym)|uniprotkb:B-cell phosphoinositide 3-kinase adapter protein 1(gene name synonym)|uniprotkb:B-cell adapter for phosphoinositide 3-kinase(gene name synonym)|uniprotkb:Pik3ap1(gene name)|psi-mi:Pik3ap1(display_short)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651612	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_113553.1|ensembl:ENSMUSG00000025017(gene)|ensembl:ENSMUST00000059672(transcript)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0034123"(positive regulation of toll-like receptor signaling pathway)|go:"GO:0034134"(toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034154"(toll-like receptor 7 signaling pathway)|go:"GO:0034162"(toll-like receptor 9 signaling pathway)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0050727"(regulation of inflammatory response)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|mint:Q9EQ32|reactome:R-MMU-1257604|reactome:R-MMU-6811558|reactome:R-MMU-983695|go:"GO:0016020"(membrane)|refseq:XP_006527535.1	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:7326(primary-reference)|afcs:30681(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:v5h9ImhUFjH726+rFktPxbfsgA810090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:B3FDCE6AE5231A50|rigid:LMzgykD9B8yEXi1abLmnSGCkbkA	false	sufficient binding region:691-811	sufficient binding region:1-377	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P25799-1	uniprotkb:O08908	intact:EBI-643974|ensembl:ENSMUSP00000029812|ensembl:ENSMUSP00000128345	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:p25799-1(display_long)|uniprotkb:p105(isoform synonym)|uniprotkb:Nfkb1(gene name)|psi-mi:Nfkb1(display_short)|uniprotkb:DNA-binding factor KBF1(gene name synonym)|uniprotkb:EBP-1(gene name synonym)|uniprotkb:NF-kappa-B1 p84/NF-kappa-B1 p98(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1(gene name synonym)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651634	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-643958(nfkb1_mouse)|ensembl:ENSMUSG00000028163(gene)|ensembl:ENSMUST00000029812(transcript)|ensembl:ENSMUST00000164430(transcript)	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:14888(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:OiCZGnyznh4scSRI6QeIuv4pHbA10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:1C3D88FB2CEDC12D|rigid:mFC1Z7FpQD6Uq0JK+ZsLmRxr5ZU	false	sufficient binding region:422-679	sufficient binding region:397-624	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CIS0	uniprotkb:O08908	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651654	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:35256(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:3DC7959B3A0F3604|rigid:53ExuY6SvAXjSh0kB5URMLWzlbU	false	sufficient binding region:108-373	sufficient binding region:397-624	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91V92	uniprotkb:Q8CFN5-4	intact:EBI-644049|ensembl:ENSMUSP00000007131|ensembl:ENSMUSP00000127632	intact:EBI-643822|ensembl:ENSMUSP00000143742	psi-mi:acly_mouse(display_long)|uniprotkb:"ATP-citrate (pro-S-)-lyase"(gene name synonym)|uniprotkb:Citrate cleavage enzyme(gene name synonym)|uniprotkb:Acly(gene name)|psi-mi:Acly(display_short)	psi-mi:q8cfn5-4(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651695	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598798.1|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR016142(Citrate synthase-like, large alpha subdomain)|interpro:IPR016143(Citrate synthase-like, small alpha subdomain)|interpro:IPR017440(ATP-citrate lyase/succinyl-CoA ligase, active site)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006084"(acetyl-CoA metabolic process)|interpro:IPR017866|interpro:IPR032263|interpro:IPR033847|interpro:IPR036291|interpro:IPR036969|mint:Q91V92|reactome:R-MMU-6798695|reactome:R-MMU-75105|go:"GO:0006085"(acetyl-CoA biosynthetic process)|go:"GO:0006101"(citrate metabolic process)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0006633"(fatty acid biosynthetic process)|go:"GO:0008610"(lipid biosynthetic process)|go:"GO:0046872"(metal ion binding)|interpro:IPR002020(Citrate synthase-like)|interpro:IPR003781(CoA-binding)|interpro:IPR005811(ATP-citrate lyase/succinyl-CoA ligase)|interpro:IPR014608(ATP-citrate synthase)|interpro:IPR016102(Succinyl-CoA synthetase-like)|ensembl:ENSMUSG00000020917(gene)|ensembl:ENSMUST00000007131(transcript)|ensembl:ENSMUST00000165111(transcript)|go:"GO:0003878"(ATP citrate synthase activity)	intact:EBI-643797(mef2c_mouse)|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000198199(transcript)	afcs:7289(primary-reference)|afcs:35254(secondary-ac)	-	isoform-comment:Contains a phosphothreonine at position 108.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c30lbMmMWWHQ2MscWeRD1ewNwxU10090	rogid:1ZAceE7Fb8MF58fpsYpHgRfA+pM10090	intact-crc:D301C0EA8EF93E06|rigid:DelsSBsAkEeJ4SspX5Lc6oexSMk	false	sufficient binding region:446-828	sufficient binding region:200-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-644088	uniprotkb:Q9JHG6	-	intact:EBI-644061|uniprotkb:Q91WQ4|uniprotkb:Q9JK50|uniprotkb:Q9JK51|uniprotkb:Q9JKK2|uniprotkb:Q9JKK3|ensembl:ENSMUSP00000060394|uniprotkb:Q7TNY3	psi-mi:q99lq9_mouse(display_short)|psi-mi:EBI-644088(display_long)|uniprotkb:Ppp3r1(gene name)|psi-mi:Ppp3r1(display_short)	psi-mi:rcan1_mouse(display_long)|uniprotkb:Regulator of calcineurin 1(gene name synonym)|uniprotkb:Down syndrome critical region protein 1 homolog(gene name synonym)|uniprotkb:Myocyte-enriched calcineurin-interacting protein 1(gene name synonym)|uniprotkb:Rcan1(gene name)|psi-mi:Rcan1(display_short)|uniprotkb:Dscr1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651736	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q99LQ9(uniprot-removed-ac)	refseq:NP_062339.2|ensembl:ENSMUSG00000022951(gene)|ensembl:ENSMUST00000060005(transcript)|go:"GO:0002931"(response to ischemia)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007614"(short-term memory)|go:"GO:0008597"(calcium-dependent protein serine/threonine phosphatase regulator activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0031987"(locomotion involved in locomotory behavior)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|go:"GO:0042802"(identical protein binding)|go:"GO:0043666"(regulation of phosphoprotein phosphatase activity)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR006931(Calcipressin)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR031271|interpro:IPR034906|interpro:IPR035979|rcsb pdb:1WEY|refseq:NP_001075018.1	afcs:23685(primary-reference)|afcs:24745(secondary-ac)	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	caution:The prey construct contains 28 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2018/06/01	rogid:3m1NMRs1S+Zf5NF4Oen0sdFyGnQ10090	rogid:JsU96N+kf20Ii4ZiIi0bTi0B/pw10090	intact-crc:B23557D6CD7D127A|rigid:yQLaqkrLAsSjFSoqLbVUpF/UoF8	false	sufficient binding region:1-112	sufficient binding region:54-247	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70433	uniprotkb:Q9DBC7	intact:EBI-299379|ensembl:ENSMUSP00000008280|ensembl:ENSMUSP00000141170|uniprotkb:P97448	intact:EBI-645677|uniprotkb:Q3UKU7|uniprotkb:Q9JHR5|uniprotkb:Q9JHR6|ensembl:ENSMUSP00000056500|ensembl:ENSMUSP00000102288	psi-mi:fhl2_mouse(display_long)|uniprotkb:Fhl2(gene name)|psi-mi:Fhl2(display_short)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)	psi-mi:kap0_mouse(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654650	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000008136(gene)|ensembl:ENSMUST00000008280(transcript)|ensembl:ENSMUST00000185893(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|refseq:NP_034342.1|refseq:XP_011236736.1|refseq:NP_001276462.1	refseq:NP_001300902.1|refseq:NP_001300903.1|refseq:NP_001300904.1|refseq:NP_001300905.1|refseq:NP_068680.1|refseq:XP_017169829.1|dip:DIP-32450N|ensembl:ENSMUSG00000020612(gene)|ensembl:ENSMUST00000049527(transcript)|ensembl:ENSMUST00000106677(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-983231|reactome:R-MMU-5610787|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:Q9DBC7|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|go:"GO:0043949"(regulation of cAMP-mediated signaling)|reactome:R-MMU-442720	afcs:20225(primary-reference)|afcs:16014(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:F/ksOc8Ay71/DwSdKCK0mehHCCs10090	rogid:0KqlQxZjK8QfS6VPEiTDtvHNTj410090	intact-crc:D10509944FBA9928|rigid:Xs21521KdxaPpHxgW2nInVLtQrA	false	sufficient binding region:9-279	sufficient binding region:119-325	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WVE8	uniprotkb:Q8CBW3	intact:EBI-645729|ensembl:ENSMUSP00000058320|ensembl:ENSMUSP00000130098|ensembl:ENSMUSP00000131504|ensembl:ENSMUSP00000155334|ensembl:ENSMUSP00000155481	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:pacn2_mouse(display_long)|uniprotkb:Pacsin2(gene name)|psi-mi:Pacsin2(display_short)|uniprotkb:Syndapin-II(gene name synonym)|uniprotkb:Syndapin-2(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654690	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152981.1|refseq:NP_001152982.1|refseq:NP_035992.1|ensembl:ENSMUSG00000016664(gene)|ensembl:ENSMUST00000056177(transcript)|ensembl:ENSMUST00000165095(transcript)|ensembl:ENSMUST00000171436(transcript)|ensembl:ENSMUST00000230679(transcript)|ensembl:ENSMUST00000231184(transcript)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007165"(signal transduction)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008289"(lipid binding)|go:"GO:0016607"(nuclear speck)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030100"(regulation of endocytosis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0036010"(protein localization to endosome)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048858"(cell projection morphogenesis)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:0070836"(caveola assembly)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001060(Cdc15/Fes/CIP4)|interpro:IPR001452(Src homology-3)|interpro:IPR027267|interpro:IPR028521|interpro:IPR031160|interpro:IPR035743|interpro:IPR036028|interpro:IPR037453|mint:Q9WVE8|rcsb pdb:3LLL|reactome:R-MMU-8856828|go:"GO:0019898"(extrinsic component of membrane)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:17043(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:5ZzVQRaqMbqn/kBzGkCvQSUX5qs10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:4DEA72D7A57FD611|rigid:pUKKf7B2va+VLZqmvLLU1Y7qRww	false	sufficient binding region:171-346	sufficient binding region:2-177	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P58771	uniprotkb:Q8CBW3	intact:EBI-298478|uniprotkb:P02558|uniprotkb:P19354|uniprotkb:P46902|uniprotkb:P99034|ensembl:ENSMUSP00000109315	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:tpm1_mouse(display_long)|uniprotkb:Tpm-1(gene name synonym)|uniprotkb:Tpma(gene name synonym)|uniprotkb:Tpm1(gene name)|psi-mi:Tpm1(display_short)|uniprotkb:Tropomyosin-1(gene name synonym)|uniprotkb:Alpha-tropomyosin(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654732	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000032366(gene)|ensembl:ENSMUST00000113685(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003065"(positive regulation of heart rate by epinephrine)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005737"(cytoplasm)|go:"GO:0005862"(muscle thin filament tropomyosin)|go:"GO:0005884"(actin filament)|go:"GO:0006936"(muscle contraction)|go:"GO:0007015"(actin filament organization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030016"(myofibril)|go:"GO:0030049"(muscle filament sliding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031529"(ruffle organization)|go:"GO:0032781"(positive regulation of ATP-dependent activity)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042060"(wound healing)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043462"(regulation of ATP-dependent activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051015"(actin filament binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051693"(actin filament capping)|go:"GO:0055010"(ventricular cardiac muscle tissue morphogenesis)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0097718"(disordered domain specific binding)|interpro:IPR000533(Tropomyosin)|mint:P58771|rcsb pdb:7NEP|reactome:R-MMU-390522|reactome:R-MMU-445355|go:"GO:0003779"(actin binding)|refseq:NP_001157720.1|refseq:NP_077745.2|dip:DIP-300N	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:11917(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:d/imATvus0XZvr7i//2MtbXZ7Pw10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:235D8A5183C9301F|rigid:ZjrzrkPzrCVLVBeUM7a8LJAX43U	false	sufficient binding region:222-284	sufficient binding region:2-317	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54931-3	uniprotkb:P12367	intact:EBI-645828|ensembl:ENSMUSP00000099966|ensembl:ENSMUSP00000099967	intact:EBI-645747	psi-mi:o54931-3(display_long)|uniprotkb:Akap2(gene name)|psi-mi:Akap2(display_short)|uniprotkb:AKAP expressed in kidney and lung(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 2(gene name synonym)|uniprotkb:KL3A(isoform synonym)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654762	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645808(akap2_mouse)|ensembl:ENSMUSG00000038729(gene)|ensembl:ENSMUST00000102902(transcript)|ensembl:ENSMUST00000102903(transcript)	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	afcs:19329(primary-reference)|afcs:15654(secondary-ac)	isoform-comment:Produced by alternative splicing.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BmKdvJPFV+F8yvKjm35Js8ahxVw10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	intact-crc:362C3A857CA587E8|rigid:xWfPjo2vB/aeDijjX5Gv4oWcSuo	false	sufficient binding region:458-617	sufficient binding region:2-126	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54931-3	uniprotkb:P12367	intact:EBI-645828|ensembl:ENSMUSP00000099966|ensembl:ENSMUSP00000099967	intact:EBI-645747	psi-mi:o54931-3(display_long)|uniprotkb:Akap2(gene name)|psi-mi:Akap2(display_short)|uniprotkb:AKAP expressed in kidney and lung(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 2(gene name synonym)|uniprotkb:KL3A(isoform synonym)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654772	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645808(akap2_mouse)|ensembl:ENSMUSG00000038729(gene)|ensembl:ENSMUST00000102902(transcript)|ensembl:ENSMUST00000102903(transcript)	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	afcs:19329(primary-reference)|afcs:15654(secondary-ac)	isoform-comment:Produced by alternative splicing.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BmKdvJPFV+F8yvKjm35Js8ahxVw10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	intact-crc:3A4B65711C97A4DF|rigid:xWfPjo2vB/aeDijjX5Gv4oWcSuo	false	sufficient binding region:554-795	sufficient binding region:2-126	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R0I7	uniprotkb:Q9DBC7	intact:EBI-644694|uniprotkb:E9QKY3|uniprotkb:Q7TMM4|ensembl:ENSMUSP00000098763	intact:EBI-645677|uniprotkb:Q3UKU7|uniprotkb:Q9JHR5|uniprotkb:Q9JHR6|ensembl:ENSMUSP00000056500|ensembl:ENSMUSP00000102288	psi-mi:ylpm1_mouse(display_long)|uniprotkb:Nuclear protein ZAP3(gene name synonym)|uniprotkb:Ylpm1(gene name)|psi-mi:Ylpm1(display_short)|uniprotkb:Zap(gene name synonym)|uniprotkb:Zap3(gene name synonym)	psi-mi:kap0_mouse(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654813	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032204"(regulation of telomere maintenance)|interpro:IPR026314|ensembl:ENSMUSG00000021244(gene)|ensembl:ENSMUST00000101202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|interpro:IPR027417|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|mint:Q9R0I7|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)	refseq:NP_001300902.1|refseq:NP_001300903.1|refseq:NP_001300904.1|refseq:NP_001300905.1|refseq:NP_068680.1|refseq:XP_017169829.1|dip:DIP-32450N|ensembl:ENSMUSG00000020612(gene)|ensembl:ENSMUST00000049527(transcript)|ensembl:ENSMUST00000106677(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-983231|reactome:R-MMU-5610787|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:Q9DBC7|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|go:"GO:0043949"(regulation of cAMP-mediated signaling)|reactome:R-MMU-442720	afcs:20225(primary-reference)|afcs:33546(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1aQLNgVl385Mxmx32eA6x9ccDg10090	rogid:0KqlQxZjK8QfS6VPEiTDtvHNTj410090	intact-crc:881EDD4070EDA437|rigid:o1yk/woytgkBhBhqFUkq87NGjbo	false	sufficient binding region:913-1260	sufficient binding region:119-325	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ERU9	uniprotkb:Q9DBC7	intact:EBI-643756|uniprotkb:E9QM01|uniprotkb:Q61992|uniprotkb:Q8C9K9|ensembl:ENSMUSP00000003310	intact:EBI-645677|uniprotkb:Q3UKU7|uniprotkb:Q9JHR5|uniprotkb:Q9JHR6|ensembl:ENSMUSP00000056500|ensembl:ENSMUSP00000102288	psi-mi:rbp2_mouse(display_long)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Ranbp2(gene name)|psi-mi:Ranbp2(display_short)	psi-mi:kap0_mouse(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654833	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035370.2|reactome:R-MMU-191859|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000003226(gene)|ensembl:ENSMUST00000003310(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:Q9ERU9|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822	refseq:NP_001300902.1|refseq:NP_001300903.1|refseq:NP_001300904.1|refseq:NP_001300905.1|refseq:NP_068680.1|refseq:XP_017169829.1|dip:DIP-32450N|ensembl:ENSMUSG00000020612(gene)|ensembl:ENSMUST00000049527(transcript)|ensembl:ENSMUST00000106677(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-983231|reactome:R-MMU-5610787|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:Q9DBC7|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|go:"GO:0043949"(regulation of cAMP-mediated signaling)|reactome:R-MMU-442720	afcs:20225(primary-reference)|afcs:35179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:cjIAIF0uuxSMRXErJiJc+OBJpAw10090	rogid:0KqlQxZjK8QfS6VPEiTDtvHNTj410090	intact-crc:D2FA53713AA2CF04|rigid:a+YRXnVsbknrw3uE6sLa/IoZNyo	false	sufficient binding region:1018-1244	sufficient binding region:119-325	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97393	uniprotkb:P12367	intact:EBI-645877|uniprotkb:E9Q0L8	intact:EBI-645747	psi-mi:rhg05_mouse(display_long)|uniprotkb:Rho-type GTPase-activating protein 5(gene name synonym)|uniprotkb:p190-B(gene name synonym)|uniprotkb:Arhgap5(gene name)|psi-mi:Arhgap5(display_short)|uniprotkb:Rhogap5(gene name synonym)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654843	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR002713(FF)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR000198(RhoGAP)|interpro:IPR001806(Ras GTPase)|interpro:IPR032835|interpro:IPR027417|interpro:IPR039006|interpro:IPR039007|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030879"(mammary gland development)|go:"GO:0042169"(SH2 domain binding)|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013405|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-9696264|reactome:R-MMU-9696270|reactome:R-MMU-9696273|interpro:IPR036517|mint:P97393	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	afcs:19329(primary-reference)|afcs:15694(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:UZnXFwmIleOpeOC7GjMIOXOz2yg10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	intact-crc:FCDE33423705889F|rigid:iT4fNQzYXKAO5KfjbsUchoNU9yU	false	sufficient binding region:1172-1361	sufficient binding region:2-126	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P50247	uniprotkb:P39428	intact:EBI-646982|uniprotkb:Q91WF1|ensembl:ENSMUSP00000061851|ensembl:ENSMUSP00000127198	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:sahh_mouse(display_long)|uniprotkb:S-adenosyl-L-homocysteine hydrolase(gene name synonym)|uniprotkb:Liver copper-binding protein(gene name synonym)|uniprotkb:CUBP(gene name synonym)|uniprotkb:Ahcy(gene name)|psi-mi:Ahcy(display_short)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657715	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057870.3|refseq:NP_001291457.1|ensembl:ENSMUSG00000027597(gene)|ensembl:ENSMUSG00000048087(gene)|ensembl:ENSMUST00000054607(transcript)|ensembl:ENSMUST00000059524(transcript)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0004013"(adenosylhomocysteinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0019510"(S-adenosylhomocysteine catabolic process)|go:"GO:0030554"(adenyl nucleotide binding)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0042470"(melanosome)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0051287"(NAD binding)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:P50247|rcsb pdb:5AXA|rcsb pdb:5AXB|rcsb pdb:5AXC|reactome:R-MMU-156581|reactome:R-MMU-1614635|rcsb pdb:5AXD	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:17645(secondary-ac)	-	-	caution:The prey construct contains 11 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3huaZIY/NrWyXH/kTaMriwT35A410090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:F9DA18563817CCE3|rigid:cQc0LJoKQ3XWrfh/yWULGYUEPB0	false	sufficient binding region:2-301	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VCY6	uniprotkb:P39428	intact:EBI-647277|uniprotkb:Q8CH76|ensembl:ENSMUSP00000046643|ensembl:ENSMUSP00000103876	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:utp6_mouse(display_long)|uniprotkb:Multiple hat domains protein(gene name synonym)|uniprotkb:Utp6(gene name)|psi-mi:Utp6(display_short)|uniprotkb:Mhat(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658149	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659075.1|ensembl:ENSMUSG00000035575(gene)|ensembl:ENSMUST00000043152(transcript)|ensembl:ENSMUST00000108241(transcript)|go:"GO:0000462"("maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)")|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0030515"(snoRNA binding)|go:"GO:0032040"(small-subunit processome)|go:"GO:0034388"(Pwp2p-containing subcomplex of 90S preribosome)|interpro:IPR003107(RNA-processing protein, HAT helix)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR013949(U3 small nucleolar RNA-associated protein 6)|reactome:R-MMU-6791226	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:53840(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:v7FuWPMyUgoCDP2+gEtMUNl9esU10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:6447A4BC5C456EA9|rigid:JdVUaY7buIGlfOzK0VoS3brfrj8	false	sufficient binding region:110-455	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O55179	uniprotkb:Q8CFA1	intact:EBI-644620|ensembl:ENSMUSP00000096087	intact:EBI-647353|uniprotkb:Q3U3K2|uniprotkb:Q3U7F5|uniprotkb:Q3UFX2|uniprotkb:Q5U404|uniprotkb:Q6YBR8|uniprotkb:Q6YBR9|uniprotkb:Q6YBS0|uniprotkb:Q6YBS1|uniprotkb:Q8C5M0|uniprotkb:Q8CC82|uniprotkb:Q8CEA0|ensembl:ENSMUSP00000055073	psi-mi:o55179_mouse(display_long)|uniprotkb:Bcl2a1d(gene name)|psi-mi:Bcl2a1d(display_short)|uniprotkb:A1d(gene name synonym)	psi-mi:irak2_mouse(display_long)|uniprotkb:Irak2(gene name)|psi-mi:Irak2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658241	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031562.1|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051400"(BH domain binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR002475(BCL2-like apoptosis inhibitor)|interpro:IPR013282(Apoptosis regulator, Bcl-2 related)|interpro:IPR020717|interpro:IPR020726|interpro:IPR026298|interpro:IPR036834|ensembl:ENSMUSG00000099974(gene)|ensembl:ENSMUST00000098486(transcript)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0030217"(T cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0044877"(protein-containing complex binding)	refseq:NP_001107025.1|refseq:NP_751893.3|refseq:XP_006505388.1|dip:DIP-49685N|ensembl:ENSMUSG00000060477(gene)|ensembl:ENSMUST00000059286(transcript)|go:"GO:0001959"(regulation of cytokine-mediated signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR033611|interpro:IPR042151|mint:Q8CFA1|reactome:R-MMU-168638|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-9020702|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-975163	afcs:53732(primary-reference)|afcs:13917(secondary-ac)	-	-	caution:The prey construct contains 18 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Vz37kK0UQf5aDMWrPeETV1B+/wI10090	rogid:rHQFchclfT+HFmBMnDzIfmSihhc10090	intact-crc:BD179CCE135F187B|rigid:bq6Dd9ciDCcqhA6y8F5SpmexvJc	false	sufficient binding region:1-159	sufficient binding region:400-622	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1R2	uniprotkb:O35305	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658273	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	afcs:15472(primary-reference)|afcs:15472(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:3DA53D32BB99BC3B|rigid:dgOZHTV6TlJ5N5X4U/W50zuqnh4	false	sufficient binding region:31-218	sufficient binding region:450-621	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60803	uniprotkb:O35305	intact:EBI-520135|uniprotkb:B2RPW3|uniprotkb:Q62380|ensembl:ENSMUSP00000021706	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:traf3_mouse(display_long)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:TRAFAMN(gene name synonym)|uniprotkb:Traf3(gene name)|psi-mi:Traf3(display_short)|uniprotkb:Craf1(gene name synonym)|uniprotkb:Trafamn(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658293	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035762.2|ensembl:ENSMUSG00000021277(gene)|ensembl:ENSMUST00000021706(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q60803|rcsb pdb:4GHU|reactome:R-MMU-5668541|reactome:R-MMU-5676594|reactome:R-MMU-5689896|reactome:R-MMU-936964|refseq:XP_006515861.1|refseq:XP_006515862.1|refseq:XP_006515863.1|refseq:XP_006515864.1|dip:DIP-34050N	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	afcs:15472(primary-reference)|afcs:55740(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2MrUSSGdyGB3zrZ39xovGDK6ysE10090	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:EF22D7092ADFDF97|rigid:taqsxFT2BVdIw9E5jrq8QF25/n4	false	sufficient binding region:169-567	sufficient binding region:450-621	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R086	uniprotkb:O35305	intact:EBI-647385|uniprotkb:Q3U3S5|uniprotkb:Q3UEP6|ensembl:ENSMUSP00000056195	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:suox_mouse(display_long)|uniprotkb:Suox(gene name)|psi-mi:Suox(display_short)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658333	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_776094.2|ensembl:ENSMUSG00000049858(gene)|ensembl:ENSMUST00000054764(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005829"(cytosol)|go:"GO:0006790"(sulfur compound metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0008482"(sulfite oxidase activity)|go:"GO:0020037"(heme binding)|go:"GO:0030151"(molybdenum ion binding)|go:"GO:0043546"(molybdopterin cofactor binding)|interpro:IPR000572(Oxidoreductase, molybdopterin binding)|interpro:IPR001199(Cytochrome b5)|interpro:IPR005066(Moybdenum cofactor oxidoreductase, dimerisation)|interpro:IPR008335(Eukaryotic molybdopterin oxidoreductase)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR018506|interpro:IPR022407|interpro:IPR036374|interpro:IPR036400|mint:Q8R086|reactome:R-MMU-1614517	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	afcs:15472(primary-reference)|afcs:58187(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:yWB8pHTvZqDWgmGL8D53h4rtQ4A10090	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:A5312433308D611F|rigid:YEYsQaR8kiIW/kQ1hCb7/DPhFmw	false	sufficient binding region:186-370	sufficient binding region:450-621	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08863	uniprotkb:P39429	intact:EBI-642236|uniprotkb:E9QLX3	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:birc3_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:Birc3(gene name)|psi-mi:Birc3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658354	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031490.2|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|mint:O08863|dip:DIP-43742N	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:13827(secondary-ac)	-	-	caution:The prey construct contains 33 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rPZRfzbIHpwQop1BRwyZl+TfhUg10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:92946229B6AA9359|rigid:wHeVbAt+bLLgWVL8zorSZQCspSo	false	sufficient binding region:1-600	sufficient binding region:143-343	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08863	uniprotkb:P39429	intact:EBI-642236|uniprotkb:E9QLX3	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:birc3_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:Birc3(gene name)|psi-mi:Birc3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658385	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031490.2|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|mint:O08863|dip:DIP-43742N	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:13827(secondary-ac)	-	-	caution:The prey construct contains 13 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rPZRfzbIHpwQop1BRwyZl+TfhUg10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:DF6794F135659FBE|rigid:wHeVbAt+bLLgWVL8zorSZQCspSo	false	sufficient binding region:1-160	sufficient binding region:143-343	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q4VAC9	uniprotkb:O35305	intact:EBI-647403|uniprotkb:E9QL46|uniprotkb:Q3TSI8|uniprotkb:Q6A041|uniprotkb:Q8BJP5|uniprotkb:Q8K0L5|uniprotkb:Q8K0T6|ensembl:ENSMUSP00000074729	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:pkhg3_mouse(display_long)|uniprotkb:Kiaa0599(gene name synonym)|uniprotkb:Plekhg3(gene name)|psi-mi:Plekhg3(display_short)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658425	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_722499.4|refseq:XP_006515938.1|dip:DIP-49616N|ensembl:ENSMUSG00000052609(gene)|ensembl:ENSMUST00000075249(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR043324|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013408	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	afcs:15472(primary-reference)|afcs:58190(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1oiz+vdN4mRWfV5/eedjFSzX2e810090	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:F1FA6F4FE07A1FE9|rigid:zRH74LAPdL+n/4b3JAAy2WDbLHE	false	sufficient binding region:586-684	sufficient binding region:450-621	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62210	uniprotkb:P39429	intact:EBI-647504|uniprotkb:O08864|uniprotkb:A6H6S7|ensembl:ENSMUSP00000091422|ensembl:ENSMUSP00000140049	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:birc2_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 2(gene name synonym)|uniprotkb:Birc2(gene name)|psi-mi:Birc2(display_short)|uniprotkb:Cellular inhibitor of apoptosis 1(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase BIRC2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658537	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031491.2|refseq:NP_001278432.1|refseq:XP_017168599.1|ensembl:ENSMUSG00000057367(gene)|ensembl:ENSMUST00000074246(transcript)|ensembl:ENSMUST00000190341(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001741"(XY body)|go:"GO:0001890"(placenta development)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0051087"(chaperone binding)|go:"GO:0051591"(response to cAMP)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0098770"(FBXO family protein binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902443"(negative regulation of ripoptosome assembly involved in necroptotic process)|go:"GO:1902523"(positive regulation of protein K63-linked ubiquitination)|go:"GO:1902524"(positive regulation of protein K48-linked ubiquitination)|go:"GO:1902527"(positive regulation of protein monoubiquitination)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000377"(regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|mint:Q62210|reactome:R-MMU-111465|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|go:"GO:0071356"(cellular response to tumor necrosis factor)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:13828(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:dYfLagyPs9Ceg7miQnJCJzKHRPk10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:E437435243BA9575|rigid:SqDU6Q/FRG3g79IUa1MYIOIZ5RM	false	sufficient binding region:37-297	sufficient binding region:143-343	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CIS0	uniprotkb:P39428	intact:EBI-643994|uniprotkb:Q4VA14|uniprotkb:Q6KAS3|uniprotkb:Q8BYV0	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:car11_mouse(display_long)|uniprotkb:Card11(gene name)|psi-mi:Card11(display_short)|uniprotkb:CARD-containing MAGUK protein 1(gene name synonym)|uniprotkb:Carma1(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658547	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_780571.2|reactome:R-MMU-2871837|go:"GO:0001772"(immunological synapse)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0031295"(T cell costimulation)|go:"GO:0032449"(CBM complex)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0038202"(TORC1 signaling)|go:"GO:0042100"(B cell proliferation)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043621"(protein self-association)|go:"GO:0045061"(thymic T cell selection)|go:"GO:0045577"(regulation of B cell differentiation)|go:"GO:0045580"(regulation of T cell differentiation)|go:"GO:0046649"(lymphocyte activation)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050700"(CARD domain binding)|go:"GO:0050776"(regulation of immune response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0050870"(positive regulation of T cell activation)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR011029(DEATH-like)|interpro:IPR027417|interpro:IPR033538|interpro:IPR036034|interpro:IPR042141|rcsb pdb:4I16|go:"GO:0045121"(membrane raft)|reactome:R-MMU-1169091|reactome:R-MMU-202424|dip:DIP-49692N|reactome:R-MMU-5607764	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:35256(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bMy3/cFVvB9lmJfmhD77Ag35Cdo10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:FABDF02B7861F7C1|rigid:oAigO99BdHaDxFyXGTnsrCjv0dY	false	sufficient binding region:276-400	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BQ30	uniprotkb:P39428	intact:EBI-647515|uniprotkb:Q3UDS6|uniprotkb:Q8CEY9|uniprotkb:Q8R3D8|uniprotkb:B8JJ63|uniprotkb:B8JJ64|ensembl:ENSMUSP00000109445|ensembl:ENSMUSP00000116100|ensembl:ENSMUSP00000120343|ensembl:ENSMUSP00000141094	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:ppr18_mouse(display_long)|uniprotkb:Ppp1r18(gene name)|psi-mi:Ppp1r18(display_short)|uniprotkb:Protein phosphatase 1 F-actin cytoskeleton-targeting subunit(gene name synonym)|uniprotkb:Protein phosphatase 1 regulatory subunit 18(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658557	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001140182.1|refseq:NP_001140183.1|refseq:NP_780451.1|refseq:XP_006525155.2|ensembl:ENSMUSG00000034595(gene)|ensembl:ENSMUST00000113814(transcript)|ensembl:ENSMUST00000122899(transcript)|ensembl:ENSMUST00000144382(transcript)|ensembl:ENSMUST00000187690(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0019902"(phosphatase binding)|interpro:IPR025903|interpro:IPR025907|interpro:IPR026671	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58155(secondary-ac)	-	-	caution:The prey construct contains 11 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:usvpwQopl2n2MPy/P62eExXBRXY10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:9B7CE8B31B5467EA|rigid:8vwmCwghSXylTL0ct1qY/RGFFZ8	false	sufficient binding region:1-182	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6NXM2	uniprotkb:P39428	intact:EBI-647528|uniprotkb:Q8BTZ6|uniprotkb:Q8BZV0	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:rcbt1_mouse(display_long)|uniprotkb:Regulator of chromosome condensation and BTB domain-containing protein 1(gene name synonym)|uniprotkb:Rcbtb1(gene name)|psi-mi:Rcbtb1(display_short)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658567	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082040.2|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR000408(Regulator of chromosome condensation, RCC1)|interpro:IPR009091(Regulator of chromosome condensation/beta-lactamase-inhibitor protein II)|refseq:XP_006519629.1|refseq:XP_006519630.1|refseq:XP_006519632.1|refseq:XP_017171693.1|refseq:XP_017171694.1|refseq:XP_006519631.1|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0007049"(cell cycle)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58182(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sjh0q/mTYUvOucQwVPQWWUqcf3A10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:55C024AA4FB17678|rigid:uIXyPeTN7GuUiLFv8KKf49AL5QU	false	sufficient binding region:442-531	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUI1	uniprotkb:P47811	intact:EBI-645081|uniprotkb:Q569F1|ensembl:ENSMUSP00000086204	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk11_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase p38 beta(gene name synonym)|uniprotkb:Mapk11(gene name)|psi-mi:Mapk11(display_short)|uniprotkb:Prkm11(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653784	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035291.4|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6804756|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000053137(gene)|ensembl:ENSMUST00000088823(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:16597(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T7B5ln4XE1gB3AwhK0A48i+Ne4Q10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:960A41764DA5D55E|rigid:YePgabS6/cCWGNkXfUwhh282msw	false	sufficient binding region:104-257	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUI1	uniprotkb:P47811	intact:EBI-645081|uniprotkb:Q569F1|ensembl:ENSMUSP00000086204	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk11_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase p38 beta(gene name synonym)|uniprotkb:Mapk11(gene name)|psi-mi:Mapk11(display_short)|uniprotkb:Prkm11(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653795	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035291.4|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6804756|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000053137(gene)|ensembl:ENSMUST00000088823(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:16597(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T7B5ln4XE1gB3AwhK0A48i+Ne4Q10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:0AAD887C91382AAB|rigid:YePgabS6/cCWGNkXfUwhh282msw	false	sufficient binding region:104-364	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUI1	uniprotkb:P47811	intact:EBI-645081|uniprotkb:Q569F1|ensembl:ENSMUSP00000086204	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk11_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase p38 beta(gene name synonym)|uniprotkb:Mapk11(gene name)|psi-mi:Mapk11(display_short)|uniprotkb:Prkm11(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653805	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035291.4|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6804756|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000053137(gene)|ensembl:ENSMUST00000088823(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:16597(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T7B5ln4XE1gB3AwhK0A48i+Ne4Q10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:30BAAED23B56BE8C|rigid:YePgabS6/cCWGNkXfUwhh282msw	false	sufficient binding region:140-364	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUI1	uniprotkb:P47811	intact:EBI-645081|uniprotkb:Q569F1|ensembl:ENSMUSP00000086204	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk11_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase p38 beta(gene name synonym)|uniprotkb:Mapk11(gene name)|psi-mi:Mapk11(display_short)|uniprotkb:Prkm11(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653815	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035291.4|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6804756|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000053137(gene)|ensembl:ENSMUST00000088823(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:16597(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T7B5ln4XE1gB3AwhK0A48i+Ne4Q10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:F145DEC787F9AB94|rigid:YePgabS6/cCWGNkXfUwhh282msw	false	sufficient binding region:169-364	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUI1	uniprotkb:P47811	intact:EBI-645081|uniprotkb:Q569F1|ensembl:ENSMUSP00000086204	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk11_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase p38 beta(gene name synonym)|uniprotkb:Mapk11(gene name)|psi-mi:Mapk11(display_short)|uniprotkb:Prkm11(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653825	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035291.4|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6804756|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000053137(gene)|ensembl:ENSMUST00000088823(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:16597(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T7B5ln4XE1gB3AwhK0A48i+Ne4Q10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:DE95863783AB686F|rigid:YePgabS6/cCWGNkXfUwhh282msw	false	sufficient binding region:229-364	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUI1	uniprotkb:P47811	intact:EBI-645081|uniprotkb:Q569F1|ensembl:ENSMUSP00000086204	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk11_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase p38 beta(gene name synonym)|uniprotkb:Mapk11(gene name)|psi-mi:Mapk11(display_short)|uniprotkb:Prkm11(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653835	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035291.4|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6804756|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000053137(gene)|ensembl:ENSMUST00000088823(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:16597(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T7B5ln4XE1gB3AwhK0A48i+Ne4Q10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:5E5F9936D19DA272|rigid:YePgabS6/cCWGNkXfUwhh282msw	false	sufficient binding region:248-364	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUI1	uniprotkb:P47811	intact:EBI-645081|uniprotkb:Q569F1|ensembl:ENSMUSP00000086204	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk11_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase p38 beta(gene name synonym)|uniprotkb:Mapk11(gene name)|psi-mi:Mapk11(display_short)|uniprotkb:Prkm11(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653845	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035291.4|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6804756|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000053137(gene)|ensembl:ENSMUST00000088823(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:16597(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T7B5ln4XE1gB3AwhK0A48i+Ne4Q10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:DDE76706E22606D2|rigid:YePgabS6/cCWGNkXfUwhh282msw	false	sufficient binding region:260-364	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUI1	uniprotkb:P47811	intact:EBI-645081|uniprotkb:Q569F1|ensembl:ENSMUSP00000086204	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk11_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase p38 beta(gene name synonym)|uniprotkb:Mapk11(gene name)|psi-mi:Mapk11(display_short)|uniprotkb:Prkm11(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653855	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035291.4|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6804756|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000053137(gene)|ensembl:ENSMUST00000088823(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:16597(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T7B5ln4XE1gB3AwhK0A48i+Ne4Q10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:AAE33B6E85B5BB12|rigid:YePgabS6/cCWGNkXfUwhh282msw	false	sufficient binding region:295-364	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61233	uniprotkb:P47811	intact:EBI-309345|uniprotkb:Q3UE24|uniprotkb:Q8R1X3|uniprotkb:Q9CV77|ensembl:ENSMUSP00000116271|ensembl:ENSMUSP00000117137|ensembl:ENSMUSP00000121201	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:plsl_mouse(display_long)|uniprotkb:Lcp1(gene name)|psi-mi:Lcp1(display_short)|uniprotkb:Pls2(gene name synonym)|uniprotkb:L-plastin(gene name synonym)|uniprotkb:Lymphocyte cytosolic protein 1(gene name synonym)|uniprotkb:65 kDa macrophage protein(gene name synonym)|uniprotkb:pp65(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653958	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032905.2|refseq:XP_006518762.1|refseq:XP_006518764.1|refseq:XP_006518765.1|refseq:XP_006518766.1|refseq:XP_006518767.1|refseq:NP_001234913.1|go:"GO:0009611"(response to wounding)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030175"(filopodium)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051639"(actin filament network formation)|go:"GO:0071803"(positive regulation of podosome assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|mint:Q61233|ensembl:ENSMUSG00000021998(gene)|ensembl:ENSMUST00000124499(transcript)|ensembl:ENSMUST00000131802(transcript)|ensembl:ENSMUST00000145303(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|refseq:XP_017171409.1	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:15044(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:kU9t6rNcFG1BiDoIuP1LuaUYl7I10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:F4EBC5CCC94CEDD2|rigid:ec2Gz08mdGi8GWbfZP3Qa2aTRqs	false	sufficient binding region:70-508	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61233	uniprotkb:P47811	intact:EBI-309345|uniprotkb:Q3UE24|uniprotkb:Q8R1X3|uniprotkb:Q9CV77|ensembl:ENSMUSP00000116271|ensembl:ENSMUSP00000117137|ensembl:ENSMUSP00000121201	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:plsl_mouse(display_long)|uniprotkb:Lcp1(gene name)|psi-mi:Lcp1(display_short)|uniprotkb:Pls2(gene name synonym)|uniprotkb:L-plastin(gene name synonym)|uniprotkb:Lymphocyte cytosolic protein 1(gene name synonym)|uniprotkb:65 kDa macrophage protein(gene name synonym)|uniprotkb:pp65(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653968	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032905.2|refseq:XP_006518762.1|refseq:XP_006518764.1|refseq:XP_006518765.1|refseq:XP_006518766.1|refseq:XP_006518767.1|refseq:NP_001234913.1|go:"GO:0009611"(response to wounding)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030175"(filopodium)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051639"(actin filament network formation)|go:"GO:0071803"(positive regulation of podosome assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|mint:Q61233|ensembl:ENSMUSG00000021998(gene)|ensembl:ENSMUST00000124499(transcript)|ensembl:ENSMUST00000131802(transcript)|ensembl:ENSMUST00000145303(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|refseq:XP_017171409.1	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:15044(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:kU9t6rNcFG1BiDoIuP1LuaUYl7I10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:03625B23EA01A6AD|rigid:ec2Gz08mdGi8GWbfZP3Qa2aTRqs	false	sufficient binding region:261-432	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61233	uniprotkb:P47811	intact:EBI-309345|uniprotkb:Q3UE24|uniprotkb:Q8R1X3|uniprotkb:Q9CV77|ensembl:ENSMUSP00000116271|ensembl:ENSMUSP00000117137|ensembl:ENSMUSP00000121201	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:plsl_mouse(display_long)|uniprotkb:Lcp1(gene name)|psi-mi:Lcp1(display_short)|uniprotkb:Pls2(gene name synonym)|uniprotkb:L-plastin(gene name synonym)|uniprotkb:Lymphocyte cytosolic protein 1(gene name synonym)|uniprotkb:65 kDa macrophage protein(gene name synonym)|uniprotkb:pp65(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653978	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032905.2|refseq:XP_006518762.1|refseq:XP_006518764.1|refseq:XP_006518765.1|refseq:XP_006518766.1|refseq:XP_006518767.1|refseq:NP_001234913.1|go:"GO:0009611"(response to wounding)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030175"(filopodium)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051639"(actin filament network formation)|go:"GO:0071803"(positive regulation of podosome assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|mint:Q61233|ensembl:ENSMUSG00000021998(gene)|ensembl:ENSMUST00000124499(transcript)|ensembl:ENSMUST00000131802(transcript)|ensembl:ENSMUST00000145303(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|refseq:XP_017171409.1	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:15044(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:kU9t6rNcFG1BiDoIuP1LuaUYl7I10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:6EAE2B96C0EB48AF|rigid:ec2Gz08mdGi8GWbfZP3Qa2aTRqs	false	sufficient binding region:261-573	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61233	uniprotkb:P47811	intact:EBI-309345|uniprotkb:Q3UE24|uniprotkb:Q8R1X3|uniprotkb:Q9CV77|ensembl:ENSMUSP00000116271|ensembl:ENSMUSP00000117137|ensembl:ENSMUSP00000121201	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:plsl_mouse(display_long)|uniprotkb:Lcp1(gene name)|psi-mi:Lcp1(display_short)|uniprotkb:Pls2(gene name synonym)|uniprotkb:L-plastin(gene name synonym)|uniprotkb:Lymphocyte cytosolic protein 1(gene name synonym)|uniprotkb:65 kDa macrophage protein(gene name synonym)|uniprotkb:pp65(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653988	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032905.2|refseq:XP_006518762.1|refseq:XP_006518764.1|refseq:XP_006518765.1|refseq:XP_006518766.1|refseq:XP_006518767.1|refseq:NP_001234913.1|go:"GO:0009611"(response to wounding)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030175"(filopodium)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051639"(actin filament network formation)|go:"GO:0071803"(positive regulation of podosome assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|mint:Q61233|ensembl:ENSMUSG00000021998(gene)|ensembl:ENSMUST00000124499(transcript)|ensembl:ENSMUST00000131802(transcript)|ensembl:ENSMUST00000145303(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|refseq:XP_017171409.1	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:15044(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:kU9t6rNcFG1BiDoIuP1LuaUYl7I10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:865193C9C102CDDB|rigid:ec2Gz08mdGi8GWbfZP3Qa2aTRqs	false	sufficient binding region:294-627	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61233	uniprotkb:P47811	intact:EBI-309345|uniprotkb:Q3UE24|uniprotkb:Q8R1X3|uniprotkb:Q9CV77|ensembl:ENSMUSP00000116271|ensembl:ENSMUSP00000117137|ensembl:ENSMUSP00000121201	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:plsl_mouse(display_long)|uniprotkb:Lcp1(gene name)|psi-mi:Lcp1(display_short)|uniprotkb:Pls2(gene name synonym)|uniprotkb:L-plastin(gene name synonym)|uniprotkb:Lymphocyte cytosolic protein 1(gene name synonym)|uniprotkb:65 kDa macrophage protein(gene name synonym)|uniprotkb:pp65(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653998	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032905.2|refseq:XP_006518762.1|refseq:XP_006518764.1|refseq:XP_006518765.1|refseq:XP_006518766.1|refseq:XP_006518767.1|refseq:NP_001234913.1|go:"GO:0009611"(response to wounding)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030175"(filopodium)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051639"(actin filament network formation)|go:"GO:0071803"(positive regulation of podosome assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|mint:Q61233|ensembl:ENSMUSG00000021998(gene)|ensembl:ENSMUST00000124499(transcript)|ensembl:ENSMUST00000131802(transcript)|ensembl:ENSMUST00000145303(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|refseq:XP_017171409.1	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:15044(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:kU9t6rNcFG1BiDoIuP1LuaUYl7I10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:EAB72AF48232505A|rigid:ec2Gz08mdGi8GWbfZP3Qa2aTRqs	false	sufficient binding region:488-583	sufficient binding region:200-360	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O89090-1	uniprotkb:P47811	intact:EBI-645205	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:o89090-1(display_long)|uniprotkb:Sp1(gene name)|psi-mi:Sp1(display_short)|uniprotkb:Specificity protein 1(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654009	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645192(sp1_mouse)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:17360(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:yl6xflCilQfKGmNQ0vKKnbMhvIs10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:B9B484FEB503AC36|rigid:bRXtM246/FWYwYFMCjQUMpJsrQQ	false	sufficient binding region:161-533	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08911	uniprotkb:P47811	intact:EBI-645214|uniprotkb:Q9D0M4|ensembl:ENSMUSP00000086207	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk12_mouse(display_long)|uniprotkb:Extracellular signal-regulated kinase 6(gene name synonym)|uniprotkb:Stress-activated protein kinase 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 gamma(gene name synonym)|uniprotkb:Mapk12(gene name)|psi-mi:Mapk12(display_short)|uniprotkb:Sapk3(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654019	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038899.1|ensembl:ENSMUSG00000022610(gene)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038786|reactome:R-MMU-168638|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-525793|reactome:R-MMU-5675221|ensembl:ENSMUST00000088827(transcript)|dip:DIP-49622N	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:17512(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mrjME9tgwfe4Bfu/d2D+JHstrLI10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:70C66FFA28BF3A85|rigid:pbIaqxCD4nPpeO4h5wLud9M2gd8	false	sufficient binding region:253-367	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WTU6-2	uniprotkb:P47811	intact:EBI-432211|ensembl:ENSMUSP00000099839|ensembl:ENSMUSP00000104808	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:q9wtu6-2(display_long)|uniprotkb:Mapk9(gene name)|psi-mi:Mapk9(display_short)|uniprotkb:Jnk2(gene name synonym)|uniprotkb:Prkm9(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 2(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654049	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020366(gene)|ensembl:ENSMUST00000102778(transcript)|ensembl:ENSMUST00000109179(transcript)|intact:EBI-298798(mk09_mouse)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17841(secondary-ac)|afcs:17113(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:UwEqrgBBGhS9sCyCbrt1RtYH8iI10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:4B35BA215EDCA506|rigid:zQsiMynZhS+yxghUxkbxNZrEmTw	false	sufficient binding region:328-381	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80SY4	uniprotkb:P47811	intact:EBI-645227|uniprotkb:Q5XK51|uniprotkb:Q6IS57|uniprotkb:Q6YI52|uniprotkb:Q6ZPT8|uniprotkb:Q8BNR1|uniprotkb:Q8C6W2|uniprotkb:Q921Q1|ensembl:ENSMUSP00000054428|ensembl:ENSMUSP00000131712	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mib1_mouse(display_long)|uniprotkb:Mind bomb homolog 1(gene name synonym)|uniprotkb:DAPK-interacting protein 1(gene name synonym)|uniprotkb:Mib1(gene name)|psi-mi:Mib1(display_short)|uniprotkb:Dip1(gene name synonym)|uniprotkb:Kiaa1323(gene name synonym)|uniprotkb:Mib(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase MIB1(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654059	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659109.2|refseq:XP_006525873.1|refseq:XP_006525874.1|ensembl:ENSMUSG00000024294(gene)|ensembl:ENSMUST00000052838(transcript)|ensembl:ENSMUST00000165555(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001756"(somitogenesis)|go:"GO:0001841"(neural tube formation)|go:"GO:0001947"(heart looping)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007219"(Notch signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008270"(zinc ion binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045807"(positive regulation of endocytosis)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002110(Ankyrin)|interpro:IPR010606(Mib-herc2)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037252|interpro:IPR040847|interpro:IPR042056|interpro:IPR043145|mint:Q80SY4	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:40260(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LiABH4Saz2Q7++kBVv3ecxbmRWo10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:1B0077F680E6F925|rigid:i0dugIiG4jsTutjyZWudm3sG2UA	false	sufficient binding region:707-1006	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CH18	uniprotkb:P47811	intact:EBI-645246|uniprotkb:Q6AXC9|uniprotkb:Q6PAR2|uniprotkb:Q80XE4|uniprotkb:Q8BJY0|uniprotkb:Q8BVN2|uniprotkb:Q8CGG1|uniprotkb:Q9CSR5|uniprotkb:Q05BR1|uniprotkb:Q05DK6|ensembl:ENSMUSP00000020268|ensembl:ENSMUSP00000151895	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:ccar1_mouse(display_long)|uniprotkb:Cell cycle and apoptosis regulatory protein 1(gene name synonym)|uniprotkb:Ccar1(gene name)|psi-mi:Ccar1(display_short)|uniprotkb:Carp1(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654069	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080477.1|refseq:XP_006514057.1|refseq:XP_006514058.1|refseq:XP_006514059.1|refseq:XP_006514060.1|refseq:XP_011241839.1|ensembl:ENSMUSG00000020074(gene)|ensembl:ENSMUST00000020268(transcript)|ensembl:ENSMUST00000219527(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005641"(nuclear envelope lumen)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006915"(apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR003034(DNA-binding SAP)|interpro:IPR011992(EF-Hand type)|interpro:IPR025223|interpro:IPR025224|interpro:IPR025954|interpro:IPR036361|mint:Q8CH18|reactome:R-MMU-72163	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:40261(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fipMhp0uguP4AXVte036ScUyq5g10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:49160D73390D8D68|rigid:lZ5bQtZbBaqj3eWbom0pqgs1atc	false	sufficient binding region:971-1136	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P34902	uniprotkb:P47811	intact:EBI-80548|ensembl:ENSMUSP00000033664	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:il2rg_mouse(display_long)|uniprotkb:Il2rg(gene name)|psi-mi:Il2rg(display_short)|uniprotkb:p64(gene name synonym)|uniprotkb:gammaC(gene name synonym)|uniprotkb:Interleukin-2 receptor subunit gamma(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654109	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031304(gene)|ensembl:ENSMUST00000033664(transcript)|go:"GO:0004896"(cytokine receptor activity)|go:"GO:0005886"(plasma membrane)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019976"(interleukin-2 binding)|go:"GO:0032831"(positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation)|go:"GO:0033089"(positive regulation of T cell differentiation in thymus)|go:"GO:0019955"(cytokine binding)|go:"GO:0035723"(interleukin-15-mediated signaling pathway)|go:"GO:0042010"(interleukin-15 receptor activity)|go:"GO:0043235"(receptor complex)|go:"GO:0045579"(positive regulation of B cell differentiation)|go:"GO:0045621"(positive regulation of lymphocyte differentiation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR003531(Short hematopoietin receptor, family 1, conserved site)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR015321(Interleukin-6 receptor alpha chain, binding)|interpro:IPR036116|rcsb pdb:6DG5|reactome:R-MMU-1266695|reactome:R-MMU-5673001|reactome:R-MMU-6785807|reactome:R-MMU-8983432|reactome:R-MMU-8985947|reactome:R-MMU-9020558|reactome:R-MMU-9020958|reactome:R-MMU-912526|refseq:NP_038591.1	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:17277(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AyGKTLNBywo1T6oOc6QrS9J2R3U10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:04B63588BD33427D|rigid:CuPNvE57dQ5rUtNeVYCx+nxGmU4	false	sufficient binding region:219-369	sufficient binding region:200-360	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60775	uniprotkb:Q9JM73	intact:EBI-645255|ensembl:ENSMUSP00000046515|ensembl:ENSMUSP00000106459	intact:EBI-493266|ensembl:ENSMUSP00000015749	psi-mi:elf1_mouse(display_long)|uniprotkb:E74-like factor 1(gene name synonym)|uniprotkb:Elf1(gene name)|psi-mi:Elf1(display_short)	psi-mi:srf_mouse(display_long)|uniprotkb:Srf(gene name)|psi-mi:Srf(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654129	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273340.1|refseq:NP_031946.1|refseq:XP_011243248.1|refseq:XP_011243249.1|ensembl:ENSMUSG00000036461(gene)|ensembl:ENSMUST00000040131(transcript)|ensembl:ENSMUST00000110835(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0030154"(cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000418(Ets)|interpro:IPR022084|interpro:IPR036388|interpro:IPR036390|mint:Q60775|reactome:R-MMU-8939247	refseq:NP_065239.1|ensembl:ENSMUSG00000015605(gene)|ensembl:ENSMUST00000015749(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001764"(neuron migration)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002521"(leukocyte differentiation)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009725"(response to hormone)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010736"(serum response element binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030038"(contractile actin filament bundle assembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030220"(platelet formation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046016"(positive regulation of transcription by glucose)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048589"(developmental growth)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060324"(face development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090398"(cellular senescence)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR033897|interpro:IPR036879|reactome:R-MMU-5663220|reactome:R-MMU-9031628|dip:DIP-49624N	afcs:18507(primary-reference)|afcs:14246(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3K8lZUUJJxckBIy58MkTk8BO6Fg10090	rogid:SQozUJAK6ZF0wewxfDKlanQwbaI10090	intact-crc:76EE3AAA6A50FE44|rigid:nfFGYYNid1BzPHN2RpcO2ZSNH+U	false	sufficient binding region:421-559	sufficient binding region:220-504	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3U1N2	uniprotkb:Q9JM73	intact:EBI-645275|uniprotkb:Q9ESZ4|uniprotkb:Q925C2|ensembl:ENSMUSP00000023100	intact:EBI-493266|ensembl:ENSMUSP00000015749	psi-mi:srbp2_mouse(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:Srebf2(gene name)|psi-mi:Srebf2(display_short)|uniprotkb:Srebp2(gene name synonym)	psi-mi:srf_mouse(display_long)|uniprotkb:Srf(gene name)|psi-mi:Srf(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654150	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150087.1|ensembl:ENSMUSG00000022463(gene)|ensembl:ENSMUST00000023100(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009725"(response to hormone)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|reactome:R-MMU-1655829|go:"GO:0008593"(regulation of Notch signaling pathway)	refseq:NP_065239.1|ensembl:ENSMUSG00000015605(gene)|ensembl:ENSMUST00000015749(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001764"(neuron migration)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002521"(leukocyte differentiation)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009725"(response to hormone)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010736"(serum response element binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030038"(contractile actin filament bundle assembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030220"(platelet formation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046016"(positive regulation of transcription by glucose)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048589"(developmental growth)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060324"(face development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090398"(cellular senescence)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR033897|interpro:IPR036879|reactome:R-MMU-5663220|reactome:R-MMU-9031628|dip:DIP-49624N	afcs:18507(primary-reference)|afcs:35117(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uDjwj6tUHAmJizC11vcpYHK/sUc10090	rogid:SQozUJAK6ZF0wewxfDKlanQwbaI10090	intact-crc:04D75F848D956830|rigid:UFyDO/pRdUSZDpJOwJcZuvXJMt4	false	sufficient binding region:81-286	sufficient binding region:220-504	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JM73	uniprotkb:Q3U1N2	intact:EBI-493266|ensembl:ENSMUSP00000015749	intact:EBI-645275|uniprotkb:Q9ESZ4|uniprotkb:Q925C2|ensembl:ENSMUSP00000023100	psi-mi:srf_mouse(display_long)|uniprotkb:Srf(gene name)|psi-mi:Srf(display_short)	psi-mi:srbp2_mouse(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:Srebf2(gene name)|psi-mi:Srebf2(display_short)|uniprotkb:Srebp2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654170	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_065239.1|ensembl:ENSMUSG00000015605(gene)|ensembl:ENSMUST00000015749(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001764"(neuron migration)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002521"(leukocyte differentiation)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009725"(response to hormone)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010736"(serum response element binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030038"(contractile actin filament bundle assembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030220"(platelet formation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046016"(positive regulation of transcription by glucose)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048589"(developmental growth)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060324"(face development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090398"(cellular senescence)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR033897|interpro:IPR036879|reactome:R-MMU-5663220|reactome:R-MMU-9031628|dip:DIP-49624N	refseq:NP_150087.1|ensembl:ENSMUSG00000022463(gene)|ensembl:ENSMUST00000023100(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009725"(response to hormone)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|reactome:R-MMU-1655829|go:"GO:0008593"(regulation of Notch signaling pathway)	afcs:18507(primary-reference)|afcs:35117(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SQozUJAK6ZF0wewxfDKlanQwbaI10090	rogid:uDjwj6tUHAmJizC11vcpYHK/sUc10090	intact-crc:1459159139FD31B9|rigid:UFyDO/pRdUSZDpJOwJcZuvXJMt4	false	sufficient binding region:220-504	sufficient binding region:161-278	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P41155	uniprotkb:P09055	intact:EBI-645287|ensembl:ENSMUSP00000025262	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:tnfc_mouse(display_long)|uniprotkb:Tumor necrosis factor C(gene name synonym)|uniprotkb:Tumor necrosis factor ligand superfamily member 3(gene name synonym)|uniprotkb:Ltb(gene name)|psi-mi:Ltb(display_short)|uniprotkb:Tnfc(gene name synonym)|uniprotkb:Tnfsf3(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654180	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032544.1|ensembl:ENSMUSG00000024399(gene)|ensembl:ENSMUST00000025262(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0010467"(gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0043588"(skin development)|go:"GO:0048535"(lymph node development)|interpro:IPR002961(Tumour necrosis factor c/lymphotoxin-beta)|interpro:IPR006052(Tumor Necrosis Factor)|interpro:IPR006053(Tumor necrosis factor alpha, beta and c)|interpro:IPR008983(Tumour necrosis factor-like)|interpro:IPR021184|reactome:R-MMU-5668541|reactome:R-MMU-5676594	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:18892(primary-reference)|afcs:14747(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:I+gqe4nCGM1YZ2ZLD+LTVVDPSS410090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:E421D216BFE2419A|rigid:V123P0QMbSeo/qmi5XxNQZ8cCs8	false	sufficient binding region:163-306	sufficient binding region:350-602	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49766-1	uniprotkb:P09055	intact:EBI-645309|ensembl:ENSMUSP00000025914	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:p49766-1(display_long)|uniprotkb:Vegfb(gene name)|psi-mi:Vegfb(display_short)|uniprotkb:Vrf(gene name synonym)|uniprotkb:VEGF-related factor(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654190	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645300(vegfb_mouse)|ensembl:ENSMUSG00000024962(gene)|ensembl:ENSMUST00000025914(transcript)	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:18892(primary-reference)|afcs:16928(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:EmTQbuWge35QfXvzI64Jpd42PxE10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:C9A3BE62230E9AD6|rigid:ThkSHH2vPDlVElMo96BXvlFOASM	false	sufficient binding region:98-207	sufficient binding region:350-602	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z2V6	uniprotkb:Q63943	intact:EBI-645339|uniprotkb:Q9JL73	intact:EBI-645322|uniprotkb:E9QKS9|uniprotkb:Q63944|ensembl:ENSMUSP00000103184	psi-mi:hdac5_mouse(display_long)|uniprotkb:Histone deacetylase mHDA1(gene name synonym)|uniprotkb:Hdac5(gene name)|psi-mi:Hdac5(display_short)	psi-mi:mef2d_mouse(display_long)|uniprotkb:Mef2d(gene name)|psi-mi:Mef2d(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654240	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0007507"(heart development)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010830"(regulation of myotube differentiation)|go:"GO:0010832"(negative regulation of myotube differentiation)|go:"GO:0016575"(histone deacetylation)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032991"(protein-containing complex)|go:"GO:0033555"(multicellular organismal response to stress)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0040029"(regulation of gene expression, epigenetic)|go:"GO:0042113"(B cell activation)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001222"(transcription corepressor binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0002076"(osteoblast development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0042220"(response to cocaine)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043393"(regulation of protein binding)|go:"GO:0044295"(axonal growth cone)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0061333"(renal tubule morphogenesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0071498"(cellular response to fluid shear stress)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090571"(RNA polymerase II transcription repressor complex)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2000648"(positive regulation of stem cell proliferation)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR024643|interpro:IPR030703|interpro:IPR037138|reactome:R-MMU-350054|dip:DIP-40855N|mint:Q9Z2V6	refseq:XP_006501152.1|refseq:NP_001297516.1|refseq:XP_017174961.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007512"(adult heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q63943|reactome:R-MMU-525793|go:"GO:0006355"(regulation of transcription, DNA-templated)|ensembl:ENSMUSG00000001419(gene)|ensembl:ENSMUST00000107559(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	afcs:21098(primary-reference)|afcs:11898(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bNOrzUxdNyh4U3deNLnjR5gIm8E10090	rogid:aOqrCwCEMvYQcHdMVQHmY7xRTnk10090	intact-crc:41C1505D9F66FB56|rigid:YZ8O9VnPZdAHqfHbfjbVIBdF7sQ	false	sufficient binding region:10-245	sufficient binding region:1-176	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99N13	uniprotkb:Q63943	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	intact:EBI-645322|uniprotkb:E9QKS9|uniprotkb:Q63944|ensembl:ENSMUSP00000103184	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:mef2d_mouse(display_long)|uniprotkb:Mef2d(gene name)|psi-mi:Mef2d(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654251	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	refseq:XP_006501152.1|refseq:NP_001297516.1|refseq:XP_017174961.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007512"(adult heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q63943|reactome:R-MMU-525793|go:"GO:0006355"(regulation of transcription, DNA-templated)|ensembl:ENSMUSG00000001419(gene)|ensembl:ENSMUST00000107559(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	afcs:21098(primary-reference)|afcs:24669(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	rogid:aOqrCwCEMvYQcHdMVQHmY7xRTnk10090	intact-crc:34D42B2E424ED0C8|rigid:+MR3j4lC0BXAqGq6oYZ3XBOWOHQ	false	sufficient binding region:26-350	sufficient binding region:1-176	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99N13	uniprotkb:Q63943	intact:EBI-645361|uniprotkb:Q4QQN7|uniprotkb:Q8R4Y6|uniprotkb:Q9EPT2	intact:EBI-645322|uniprotkb:E9QKS9|uniprotkb:Q63944|ensembl:ENSMUSP00000103184	psi-mi:hdac9_mouse(display_long)|uniprotkb:Histone deacetylase 7B(gene name synonym)|uniprotkb:Histone deacetylase-related protein(gene name synonym)|uniprotkb:MEF2-interacting transcription repressor MITR(gene name synonym)|uniprotkb:Hdac9(gene name)|psi-mi:Hdac9(display_short)|uniprotkb:Hdac7b(gene name synonym)|uniprotkb:Hdrp(gene name synonym)|uniprotkb:Mitr(gene name synonym)	psi-mi:mef2d_mouse(display_long)|uniprotkb:Mef2d(gene name)|psi-mi:Mef2d(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654261	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077038.2|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006281"(DNA repair)|go:"GO:0006325"(chromatin organization)|go:"GO:0006954"(inflammatory response)|go:"GO:0007399"(nervous system development)|go:"GO:0007507"(heart development)|go:"GO:0008340"(determination of adult lifespan)|dip:DIP-41905N|go:"GO:0016575"(histone deacetylation)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0034739"("histone deacetylase activity (H4-K16 specific)")|go:"GO:0034983"(peptidyl-lysine deacetylation)|go:"GO:0035097"(histone methyltransferase complex)|go:"GO:0042113"(B cell activation)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048742"(regulation of skeletal muscle fiber development)|go:"GO:0051005"(negative regulation of lipoprotein lipase activity)|go:"GO:0051153"(regulation of striated muscle cell differentiation)|go:"GO:0070932"(histone H3 deacetylation)|go:"GO:0070933"(histone H4 deacetylation)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1990678"(histone H4-K16 deacetylation)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR024643|rcsb pdb:1TQE	refseq:XP_006501152.1|refseq:NP_001297516.1|refseq:XP_017174961.1|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006915"(apoptotic process)|go:"GO:0007399"(nervous system development)|go:"GO:0007512"(adult heart development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR022102|interpro:IPR033896|interpro:IPR036879|mint:Q63943|reactome:R-MMU-525793|go:"GO:0006355"(regulation of transcription, DNA-templated)|ensembl:ENSMUSG00000001419(gene)|ensembl:ENSMUST00000107559(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001958"(endochondral ossification)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	afcs:21098(primary-reference)|afcs:24669(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PFLDukT41qTdipVVfoa+Ck+6A6M10090	rogid:aOqrCwCEMvYQcHdMVQHmY7xRTnk10090	intact-crc:72F3A3100767F502|rigid:+MR3j4lC0BXAqGq6oYZ3XBOWOHQ	false	sufficient binding region:135-351	sufficient binding region:1-176	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QX47-2	uniprotkb:Q8BWG8	intact:EBI-643055|ensembl:ENSMUSP00000109670	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:q9qx47-2(display_long)|uniprotkb:Nrebp(gene name synonym)|uniprotkb:Negative regulatory element-binding protein(gene name synonym)|uniprotkb:Son(gene name)|psi-mi:Son(display_short)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-643037(son_mouse)|ensembl:ENSMUSG00000022961(gene)|ensembl:ENSMUST00000114036(transcript)	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:18406(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JyhEp99sJRLALu/9cXM5hv1zliw10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:88CBF201F9048E03|rigid:IOw5MUiNp61vHV3SLGjOz4/o7ZY	false	sufficient binding region:1737-1820	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R550	uniprotkb:Q9QUN3	intact:EBI-642709|uniprotkb:Q8CAL8|uniprotkb:Q8CEF6|uniprotkb:Q8R545|uniprotkb:Q8R546|uniprotkb:Q8R547|uniprotkb:Q8R548|uniprotkb:Q8R549|uniprotkb:Q8R551|uniprotkb:Q9CTQ9|uniprotkb:Q9DC14|uniprotkb:Q9JKC3|uniprotkb:B1AZ86|uniprotkb:B1AZ87|ensembl:ENSMUSP00000072840	intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844	psi-mi:sh3k1_mouse(display_long)|uniprotkb:SH3-containing, expressed in tumorigenic astrocytes(gene name synonym)|uniprotkb:Regulator of ubiquitous kinase(gene name synonym)|uniprotkb:Sh3kbp1(gene name)|psi-mi:Sh3kbp1(display_short)|uniprotkb:Ruk(gene name synonym)|uniprotkb:Seta(gene name synonym)	psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650580	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001129199.1|refseq:NP_001129200.1|refseq:NP_067364.2|refseq:XP_006528987.1|ensembl:ENSMUSG00000040990(gene)|ensembl:ENSMUST00000073094(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006897"(endocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030139"(endocytic vesicle)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0043005"(neuron projection)|go:"GO:0045202"(synapse)|go:"GO:0050871"(positive regulation of B cell activation)|interpro:IPR001452(Src homology-3)|interpro:IPR028506|interpro:IPR035770|interpro:IPR035771|interpro:IPR035772|interpro:IPR036028|mint:Q8R550|rcsb pdb:1WI7|rcsb pdb:2DA9|rcsb pdb:5XHZ|reactome:R-MMU-182971|reactome:R-MMU-6807004|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8866376|reactome:R-MMU-983695|refseq:XP_011246151.1|refseq:XP_011246153.1|refseq:NP_001277590.1|refseq:NP_001277593.1	refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)	afcs:21969(primary-reference)|afcs:23893(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Fd7WikE+fZIgob7Ax2vr9J291N010090	rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090	intact-crc:E096FFED04F097D1|rigid:CitRBks8Wrj5b3/GWKwylOMFTa8	false	sufficient binding region:218-520	sufficient binding region:150-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1T1	uniprotkb:P35991	intact:EBI-643061|uniprotkb:E9QQ08|uniprotkb:Q91YR4|ensembl:ENSMUSP00000022196	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:ap3b1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-3 subunit beta-1(gene name synonym)|uniprotkb:Beta-3A-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 3 beta-1 large chain(gene name synonym)|uniprotkb:Ap3b1(gene name)|psi-mi:Ap3b1(display_short)|uniprotkb:Adaptor-related protein complex 3 subunit beta-1(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650590	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033810.2|ensembl:ENSMUSG00000021686(gene)|ensembl:ENSMUST00000022196(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003016"(respiratory system process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006954"(inflammatory response)|go:"GO:0007040"(lysosome organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030324"(lung development)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032438"(melanosome organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0043473"(pigmentation)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0090152"(establishment of protein localization to mitochondrial membrane involved in mitochondrial fission)|go:"GO:0098773"(skin epidermis development)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026739|interpro:IPR026740|interpro:IPR029390|interpro:IPR029394|mint:Q9Z1T1|reactome:R-MMU-432722|dip:DIP-49018N	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:15675(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Xtcoo5Kk0ZYpVbr+WEBfVxidkVU10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:01C17B81D8227273|rigid:MNQPtkBqhTkc8CKGZOqA7ouzK6M	false	sufficient binding region:917-1105	sufficient binding region:210-280	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61656	uniprotkb:P35991	intact:EBI-643076|uniprotkb:E9Q105	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:ddx5_mouse(display_long)|uniprotkb:DEAD box protein 5(gene name synonym)|uniprotkb:RNA helicase p68(gene name synonym)|uniprotkb:DEAD box RNA helicase DEAD1(gene name synonym)|uniprotkb:Ddx5(gene name)|psi-mi:Ddx5(display_short)|uniprotkb:Tnz2(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650600	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR012587(P68HR)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|interpro:IPR027417|reactome:R-MMU-3899300|reactome:R-MMU-72163|reactome:R-MMU-9018519|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000380"(alternative mRNA splicing, via spliceosome)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000956"(nuclear-transcribed mRNA catabolic process)|go:"GO:0001837"(epithelial to mesenchymal transition)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007623"(circadian rhythm)|go:"GO:0009299"(mRNA transcription)|go:"GO:0019899"(enzyme binding)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0030520"(intracellular estrogen receptor signaling pathway)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0035500"(MH2 domain binding)|go:"GO:0036002"(pre-mRNA binding)|go:"GO:0043021"(ribonucleoprotein complex binding)|go:"GO:0043517"(positive regulation of DNA damage response, signal transduction by p53 class mediator)|go:"GO:0045069"(regulation of viral genome replication)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061614"(miRNA transcription)|go:"GO:0070412"(R-SMAD binding)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0072332"(intrinsic apoptotic signaling pathway by p53 class mediator)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903800"(positive regulation of production of miRNAs involved in gene silencing by miRNA)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2001014"(regulation of skeletal muscle cell differentiation)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|dip:DIP-32293N|mint:Q61656	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:14179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:X5OQN/Gdq852njTrHnlDliAjrQY10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:A7FB103E9EABC703|rigid:zTytXJGcw3wFPt1TpOQ5s8smCoA	false	sufficient binding region:369-564	sufficient binding region:210-280	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35654	uniprotkb:Q60591	intact:EBI-643134|uniprotkb:Q99J61|ensembl:ENSMUSP00000099986	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:dpod2_mouse(display_long)|uniprotkb:DNA polymerase delta subunit p50(gene name synonym)|uniprotkb:Pold2(gene name)|psi-mi:Pold2(display_short)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650621	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032920.2|refseq:XP_006514650.1|ensembl:ENSMUSG00000020471(gene)|ensembl:ENSMUST00000102922(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006260"(DNA replication)|go:"GO:0006261"(DNA-dependent DNA replication)|go:"GO:0006271"(DNA strand elongation involved in DNA replication)|go:"GO:0006281"(DNA repair)|go:"GO:0042575"(DNA polymerase complex)|go:"GO:0043625"(delta DNA polymerase complex)|go:"GO:0071897"(DNA biosynthetic process)|interpro:IPR007185(DNA polymerase alpha/epsilon, subunit B)|interpro:IPR024826|interpro:IPR040663|interpro:IPR041863|reactome:R-MMU-110314|reactome:R-MMU-174411|reactome:R-MMU-174414|reactome:R-MMU-174417|reactome:R-MMU-174437|reactome:R-MMU-5358565|reactome:R-MMU-5358606|reactome:R-MMU-5651801|reactome:R-MMU-5656169|reactome:R-MMU-5685942|reactome:R-MMU-5696397|reactome:R-MMU-5696400|reactome:R-MMU-6782135|reactome:R-MMU-6782210|reactome:R-MMU-69091|reactome:R-MMU-69166|reactome:R-MMU-69183|go:"GO:0016035"(zeta DNA polymerase complex)	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	afcs:53032(primary-reference)|afcs:15058(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:eDVDjCipz2OOM4K5zryjoRpB/Dc10090	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	intact-crc:46FEDC176978F877|rigid:JGwH26DjENSCcbwLektkMoBsUdQ	false	sufficient binding region:309-469	sufficient binding region:200-420	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35381	uniprotkb:Q60591	intact:EBI-643140|uniprotkb:P97437|ensembl:ENSMUSP00000082652	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:an32a_mouse(display_long)|uniprotkb:Potent heat-stable protein phosphatase 2A inhibitor I1PP2A(gene name synonym)|uniprotkb:Acidic nuclear phosphoprotein pp32(gene name synonym)|uniprotkb:Leucine-rich acidic nuclear protein(gene name synonym)|uniprotkb:Anp32a(gene name)|psi-mi:Anp32a(display_short)|uniprotkb:Anp32(gene name synonym)|uniprotkb:Lanp(gene name synonym)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650632	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033802.2|ensembl:ENSMUSG00000032249(gene)|ensembl:ENSMUST00000085519(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0042393"(histone binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:O35381|rcsb pdb:2JQD|reactome:R-MMU-450520	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	afcs:53032(primary-reference)|afcs:15668(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:flk6xO1N5PloQyQ9bOBHDzr3Hr010090	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	intact-crc:F7F44CB14074B7F7|rigid:aUs2NoAU3eDP1uoDOBzQobx0Z6w	false	sufficient binding region:3-165	sufficient binding region:200-420	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JLQ2	uniprotkb:Q91YD9	intact:EBI-642860|uniprotkb:E9QPU7|ensembl:ENSMUSP00000107803	intact:EBI-642417|ensembl:ENSMUSP00000031695	psi-mi:git2_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 2(gene name synonym)|uniprotkb:GRK-interacting protein 2(gene name synonym)|uniprotkb:Cool-interacting tyrosine-phosphorylated protein 2(gene name synonym)|uniprotkb:Git2(gene name)|psi-mi:Git2(display_short)	psi-mi:wasl_mouse(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650652	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062808.3|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q9JLQ2|rcsb pdb:6JMT|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|ensembl:ENSMUSG00000041890(gene)|ensembl:ENSMUST00000112185(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)	refseq:NP_082735.2|ensembl:ENSMUSG00000029684(gene)|ensembl:ENSMUST00000031695(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010324"(membrane invagination)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045010"(actin nucleation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:Q91YD9|rcsb pdb:3M3N|rcsb pdb:6UHC|dip:DIP-29788N	afcs:21850(primary-reference)|afcs:18337(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mOkKto/u8bzW0feEp3Kah7fYeOI10090	rogid:TXI8wfugOptN0kVS3yEJxaM4uq810090	intact-crc:AE7F928A75B45E66|rigid:mrw2XkswFNqGXNbbq2sXvjWgN08	false	sufficient binding region:1-366	sufficient binding region:1-210	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JLQ2	uniprotkb:Q91YD9	intact:EBI-642860|uniprotkb:E9QPU7|ensembl:ENSMUSP00000107803	intact:EBI-642417|ensembl:ENSMUSP00000031695	psi-mi:git2_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 2(gene name synonym)|uniprotkb:GRK-interacting protein 2(gene name synonym)|uniprotkb:Cool-interacting tyrosine-phosphorylated protein 2(gene name synonym)|uniprotkb:Git2(gene name)|psi-mi:Git2(display_short)	psi-mi:wasl_mouse(display_long)|uniprotkb:Wasl(gene name)|psi-mi:Wasl(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650662	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062808.3|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q9JLQ2|rcsb pdb:6JMT|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|ensembl:ENSMUSG00000041890(gene)|ensembl:ENSMUST00000112185(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)	refseq:NP_082735.2|ensembl:ENSMUSG00000029684(gene)|ensembl:ENSMUST00000031695(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0010324"(membrane invagination)|go:"GO:0016050"(vesicle organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030050"(vesicle transport along actin filament)|go:"GO:0030478"(actin cap)|go:"GO:0031252"(cell leading edge)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0034629"|go:"GO:0042802"(identical protein binding)|go:"GO:0045010"(actin nucleation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0051301"(cell division)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051653"(spindle localization)|go:"GO:0060997"(dendritic spine morphogenesis)|go:"GO:0097320"(plasma membrane tubulation)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1903526"(negative regulation of membrane tubulation)|go:"GO:2000370"(positive regulation of clathrin-dependent endocytosis)|go:"GO:2000402"(negative regulation of lymphocyte migration)|go:"GO:0060491"(regulation of cell projection assembly)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR030214|interpro:IPR033927|interpro:IPR036936|mint:Q91YD9|rcsb pdb:3M3N|rcsb pdb:6UHC|dip:DIP-29788N	afcs:21850(primary-reference)|afcs:18337(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mOkKto/u8bzW0feEp3Kah7fYeOI10090	rogid:TXI8wfugOptN0kVS3yEJxaM4uq810090	intact-crc:421F8F662A572C4B|rigid:mrw2XkswFNqGXNbbq2sXvjWgN08	false	sufficient binding region:249-274	sufficient binding region:1-210	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3URD3-4	uniprotkb:Q8BH43	intact:EBI-3294998|intact:EBI-647394	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:q3urd3-4(display_long)|uniprotkb:Slmap(gene name)|psi-mi:Slmap(display_short)|uniprotkb:Kiaa1601(gene name synonym)|uniprotkb:Slap(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650703	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-643207(isoform-parent)	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34965(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:z1xfy2NNULIGTqg9HvzD9/EHRCQ10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:8CABCA463DA723E9|rigid:4a6pwCubc5XFX1dpL15fLx0epeY	false	sufficient binding region:50-359	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3URD3-4	uniprotkb:Q8BH43	intact:EBI-3294998|intact:EBI-647394	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:q3urd3-4(display_long)|uniprotkb:Slmap(gene name)|psi-mi:Slmap(display_short)|uniprotkb:Kiaa1601(gene name synonym)|uniprotkb:Slap(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650713	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-643207(isoform-parent)	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34965(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:z1xfy2NNULIGTqg9HvzD9/EHRCQ10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:77F15FA533E79ADC|rigid:4a6pwCubc5XFX1dpL15fLx0epeY	false	sufficient binding region:190-352	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q70FJ1	uniprotkb:P12367	intact:EBI-645887|uniprotkb:Q3TH74|uniprotkb:Q80TR6	intact:EBI-645747	psi-mi:akap9_mouse(display_long)|uniprotkb:Akap9(gene name)|psi-mi:Akap9(display_short)|uniprotkb:Kiaa0803(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 9(gene name synonym)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654853	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_919444.2|interpro:IPR019528|interpro:IPR028745|go:"GO:0000242"(pericentriolar material)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005795"(Golgi stack)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005813"(centrosome)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007165"(signal transduction)|go:"GO:0007194"(negative regulation of adenylate cyclase activity)|go:"GO:0007283"(spermatogenesis)|go:"GO:0015459"(potassium channel regulator activity)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0034705"(potassium channel complex)|go:"GO:0036064"(ciliary basal body)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044307"(dendritic branch)|go:"GO:0051661"(maintenance of centrosome location)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060307"(regulation of ventricular cardiac muscle cell membrane repolarization)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097729"(9+2 motile cilium)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0120219"(subapical part of cell)|go:"GO:1901018"(positive regulation of potassium ion transmembrane transporter activity)|go:"GO:1903358"(regulation of Golgi organization)|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5576890|reactome:R-MMU-5576893|reactome:R-MMU-5620912|reactome:R-MMU-8854518|mint:Q70FJ1	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	afcs:19329(primary-reference)|afcs:53749(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:9yyCeoX35wNULJg413iGM9TIQxA10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	intact-crc:63DF5D7108E338BC|rigid:y/BGFzi+EFLLyLcvALx8A77dIKM	false	sufficient binding region:1296-1568	sufficient binding region:2-126	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CRT8	uniprotkb:Q9Z1T1	intact:EBI-644629|uniprotkb:Q52KI1|ensembl:ENSMUSP00000043488	intact:EBI-643061|uniprotkb:E9QQ08|uniprotkb:Q91YR4|ensembl:ENSMUSP00000022196	psi-mi:xpot_mouse(display_long)|uniprotkb:tRNA exportin(gene name synonym)|uniprotkb:"Exportin(tRNA)"(gene name synonym)|uniprotkb:Xpot(gene name)|psi-mi:Xpot(display_short)	psi-mi:ap3b1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-3 subunit beta-1(gene name synonym)|uniprotkb:Beta-3A-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 3 beta-1 large chain(gene name synonym)|uniprotkb:Ap3b1(gene name)|psi-mi:Ap3b1(display_short)|uniprotkb:Adaptor-related protein complex 3 subunit beta-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654863	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034667(gene)|ensembl:ENSMUST00000039810(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006409"(tRNA export from nucleus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0016363"(nuclear matrix)|go:"GO:0031267"(small GTPase binding)|go:"GO:0071528"(tRNA re-export from nucleus)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013598(Exportin-1/Importin-beta-like)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040017|mint:Q9CRT8	refseq:NP_033810.2|ensembl:ENSMUSG00000021686(gene)|ensembl:ENSMUST00000022196(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003016"(respiratory system process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006954"(inflammatory response)|go:"GO:0007040"(lysosome organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030324"(lung development)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032438"(melanosome organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0043473"(pigmentation)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0090152"(establishment of protein localization to mitochondrial membrane involved in mitochondrial fission)|go:"GO:0098773"(skin epidermis development)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026739|interpro:IPR026740|interpro:IPR029390|interpro:IPR029394|mint:Q9Z1T1|reactome:R-MMU-432722|dip:DIP-49018N	afcs:15675(primary-reference)|afcs:53752(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sxoS4tNMBaRRDwVJM5HlK1c2avE10090	rogid:Xtcoo5Kk0ZYpVbr+WEBfVxidkVU10090	intact-crc:D6AD7D8745B7B3CA|rigid:COuM63Py+uKOHvsytbJYrzd7+yc	false	sufficient binding region:1-89	sufficient binding region:1-201	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BQ46	uniprotkb:Q9DBC7	intact:EBI-645898|ensembl:ENSMUSP00000021018	intact:EBI-645677|uniprotkb:Q3UKU7|uniprotkb:Q9JHR5|uniprotkb:Q9JHR6|ensembl:ENSMUSP00000056500|ensembl:ENSMUSP00000102288	psi-mi:q8bq46_mouse(display_long)|uniprotkb:Taf15(gene name)|psi-mi:Taf15(display_short)	psi-mi:kap0_mouse(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654874	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081703.1|ensembl:ENSMUSG00000020680(gene)|ensembl:ENSMUST00000021018(transcript)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0008380"(RNA splicing)|go:"GO:0010467"(gene expression)|go:"GO:0046872"(metal ion binding)|go:"GO:0048255"(mRNA stabilization)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034870|interpro:IPR034875|interpro:IPR035979|interpro:IPR036443|mint:Q8BQ46|reactome:R-MMU-674695|reactome:R-MMU-6804756|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042	refseq:NP_001300902.1|refseq:NP_001300903.1|refseq:NP_001300904.1|refseq:NP_001300905.1|refseq:NP_068680.1|refseq:XP_017169829.1|dip:DIP-32450N|ensembl:ENSMUSG00000020612(gene)|ensembl:ENSMUST00000049527(transcript)|ensembl:ENSMUST00000106677(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-983231|reactome:R-MMU-5610787|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:Q9DBC7|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|go:"GO:0043949"(regulation of cAMP-mediated signaling)|reactome:R-MMU-442720	afcs:20225(primary-reference)|afcs:53759(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:IIxzQ1cZR0jQ0HIn6PUfdNwfuH410090	rogid:0KqlQxZjK8QfS6VPEiTDtvHNTj410090	intact-crc:9B1C5073AB9FEBED|rigid:cfSJYiWyOVYZAQEeGuhWIi3scTE	false	sufficient binding region:271-441	sufficient binding region:119-325	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0K2	uniprotkb:P12849	intact:EBI-645913|uniprotkb:Q9CV92|uniprotkb:Q3TIW6|ensembl:ENSMUSP00000106318	intact:EBI-645585|ensembl:ENSMUSP00000026973|ensembl:ENSMUSP00000106515	psi-mi:scot1_mouse(display_long)|uniprotkb:"Somatic-type succinyl-CoA:3-oxoacid CoA-transferase"(gene name synonym)|uniprotkb:Oxct1(gene name)|psi-mi:Oxct1(display_short)|uniprotkb:Oxct(gene name synonym)|uniprotkb:Scot(gene name synonym)|uniprotkb:3-oxoacid CoA-transferase 1(gene name synonym)	psi-mi:kap1_mouse(display_long)|uniprotkb:Prkar1b(gene name)|psi-mi:Prkar1b(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654884	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077150.1|interpro:IPR004163(Coenzyme A transferase binding site)|interpro:IPR004164(Coenzyme A transferase active site)|interpro:IPR004165(Coenzyme A transferase)|interpro:IPR012791(3-oxoacid CoA-transferase, subunit B)|interpro:IPR012792(3-oxoacid CoA-transferase, subunit A)|interpro:IPR014388(3-oxoacid CoA-transferase)|interpro:IPR037171|mint:Q9D0K2|reactome:R-MMU-77108|ensembl:ENSMUST00000110690(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0007584"(response to nutrient)|go:"GO:0008260"(3-oxoacid CoA-transferase activity)|go:"GO:0008410"(CoA-transferase activity)|go:"GO:0009725"(response to hormone)|go:"GO:0014823"(response to activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042182"(ketone catabolic process)|go:"GO:0042493"|go:"GO:0042594"(response to starvation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045471"(response to ethanol)|go:"GO:0046950"(cellular ketone body metabolic process)|go:"GO:0046952"(ketone body catabolic process)|go:"GO:0060612"(adipose tissue development)|ensembl:ENSMUSG00000022186(gene)	refseq:NP_032949.3|refseq:XP_006504723.1|refseq:XP_006504724.1|refseq:XP_006504726.1|refseq:NP_001240819.1|refseq:XP_017176208.1|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0030552"(cAMP binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|go:"GO:0009887"(animal organ morphogenesis)|interpro:IPR018488|interpro:IPR018490|interpro:IPR042818|mint:P12849|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720|reactome:R-MMU-5610787|reactome:R-MMU-983231|ensembl:ENSMUSG00000025855(gene)|ensembl:ENSMUST00000026973(transcript)|ensembl:ENSMUST00000110890(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007611"(learning or memory)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)	afcs:15079(primary-reference)|afcs:53760(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:KSJpQdbufFtI07fqqPLQdJrkT2I10090	rogid:w65y6gB5uVAjfKjbAidQPpWtgAo10090	intact-crc:1B965610D74E008E|rigid:4kQBD9XlyGF6lCYfBEdD2RAQmj4	false	sufficient binding region:287-470	sufficient binding region:2-381	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61053	uniprotkb:Q8CBW3	intact:EBI-645927	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:q61053_mouse(display_long)|uniprotkb:Fnbp1(gene name)|psi-mi:Fnbp1(display_short)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654894	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001452(Src homology-3)|interpro:IPR028532|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR036028|interpro:IPR011072(HR1 rho-binding repeat)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:53761(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3mtAdYK1I1lbz0iCkvGUhUVfY9c10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:CD78E9FE65607746|rigid:UfNJLJZ55BhzizRsuL7siqJOI9E	false	sufficient binding region:65-232	sufficient binding region:2-317	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61053	uniprotkb:Q8CBW3	intact:EBI-645927	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:q61053_mouse(display_long)|uniprotkb:Fnbp1(gene name)|psi-mi:Fnbp1(display_short)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654904	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001452(Src homology-3)|interpro:IPR028532|go:"GO:0006897"(endocytosis)|go:"GO:0007165"(signal transduction)|interpro:IPR036028|interpro:IPR011072(HR1 rho-binding repeat)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:53761(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3mtAdYK1I1lbz0iCkvGUhUVfY9c10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:2A0ABE452166E97B|rigid:UfNJLJZ55BhzizRsuL7siqJOI9E	false	sufficient binding region:77-237	sufficient binding region:2-317	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q68FF6	uniprotkb:O70172	intact:EBI-645933|ensembl:ENSMUSP00000037210	intact:EBI-644828|ensembl:ENSMUSP00000006912	psi-mi:git1_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 1(gene name synonym)|uniprotkb:GRK-interacting protein 1(gene name synonym)|uniprotkb:Git1(gene name)|psi-mi:Git1(display_short)	psi-mi:pi42a_mouse(display_long)|uniprotkb:"PtdIns(5)P-4-kinase isoform 2-alpha"(gene name synonym)|uniprotkb:Diphosphoinositide kinase 2-alpha(gene name synonym)|uniprotkb:Pip4k2a(gene name)|psi-mi:Pip4k2a(display_short)|uniprotkb:Pip5k2a(gene name synonym)|uniprotkb:1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-Phosphate 4-Kinase(gene name synonym)|uniprotkb:Pi5p4ka(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654914	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001004144.1|ensembl:ENSMUSG00000011877(gene)|ensembl:ENSMUST00000037285(transcript)|go:"GO:0001771"(immunological synapse formation)|go:"GO:0001957"(intramembranous ossification)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005925"(focal adhesion)|go:"GO:0007420"(brain development)|go:"GO:0007626"(locomotory behavior)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030027"(lamellipodium)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032013"(negative regulation of ARF protein signal transduction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045454"(cell redox homeostasis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0046872"(metal ion binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048666"(neuron development)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061743"(motor learning)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098879"(structural constituent of postsynaptic specialization)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)|go:"GO:0099645"(neurotransmitter receptor localization to postsynaptic specialization membrane)|go:"GO:0106015"(negative regulation of inflammatory response to wounding)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:2000646"(positive regulation of receptor catabolic process)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR032352|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q68FF6|rcsb pdb:6JMU|reactome:R-MMU-3928664|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424	refseq:NP_032871.3|ensembl:ENSMUSG00000026737(gene)|ensembl:ENSMUST00000006912(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0090119"(vesicle-mediated cholesterol transport)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:O70172|reactome:R-MMU-1660499|reactome:R-MMU-6811555|reactome:R-MMU-6811558|reactome:R-MMU-8847453|dip:DIP-49438N	afcs:15014(primary-reference)|afcs:53768(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3br9Xz6GZQV409u3u7CZDfqKMIM10090	rogid:tnXc4oMaOV1P8hQRrM6/4G5CPOQ10090	intact-crc:20C68FBAAFDDCA35|rigid:nO49oTV656TQsSOIzhx4g7LLbZ4	false	sufficient binding region:179-394	sufficient binding region:300-405	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q924X9	uniprotkb:P12367	intact:EBI-685481	intact:EBI-645747	psi-mi:q924x9_mouse(display_long)|uniprotkb:Akap13(gene name)|psi-mi:Akap13(display_short)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688203	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR028852|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0035023"(regulation of Rho protein signal transduction)	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	afcs:19329(primary-reference)|afcs:53754(primary-reference)|afcs:53754(secondary-ac)	caution:"Protein [uniprotkb:Q924X9] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"|comment:"A kinase (PRKA) anchor protein 13; type II cAMP-dependent protein kinase anchoring protein Ht31; BRX; LBC; AKAP-Lbc; PROTO-LB; PROTO-LBC"|comment:AfCS Y2H protein. Translated from nucleotide sequence.|caution:"The sequence differs in amino-terminus to AfCS ID: A000240 and is truncated at the C-terminus."|comment:"similar to a mouse AKAP13 fragment (99%)."	-	caution:"Protein [uniprotkb:Q924X9] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:iGu7PI8I+0GMvjAKc8o5okpPcUg10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	intact-crc:DA6DC9C095EC4C0C|rigid:joqswUaaxQ31A6hvgwCMTBteAkE	false	sufficient binding region:?-?	sufficient binding region:2-126	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6ZQ08	uniprotkb:P09055	intact:EBI-682479|intact:EBI-2104684|uniprotkb:B2RY28|uniprotkb:Q3UPB7|uniprotkb:Q8BSB4|uniprotkb:Q8BXB2|uniprotkb:Q8C0H2|uniprotkb:Q8K3D8	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:cnot1_mouse(display_long)|uniprotkb:Cnot1(gene name)|psi-mi:Cnot1(display_short)|uniprotkb:Kiaa1007(gene name synonym)|uniprotkb:CCR4-associated factor 1(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688179	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_835179.1|refseq:XP_006530937.1|dip:DIP-46845N|mint:Q6ZQ08|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000288"(nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:0000932"(P-body)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0004535"("poly(A)-specific ribonuclease activity")|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0010606"(positive regulation of cytoplasmic mRNA processing body assembly)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030014"(CCR4-NOT complex)|go:"GO:0030015"(CCR4-NOT core complex)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0033147"(negative regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035195"(gene silencing by miRNA)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0048387"(negative regulation of retinoic acid receptor signaling pathway)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060213"("positive regulation of nuclear-transcribed mRNA poly(A) tail shortening")|go:"GO:0061014"(positive regulation of mRNA catabolic process)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:1900153"(positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay)|go:"GO:2000036"(regulation of stem cell population maintenance)|interpro:IPR007196(CCR4-Not complex component, Not1)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR024557|interpro:IPR032191|interpro:IPR032193|interpro:IPR032194|interpro:IPR038535|interpro:IPR040398|reactome:R-MMU-429947|reactome:R-MMU-6804115	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:18892(primary-reference)|afcs:39306(primary-reference)|afcs:39306(secondary-ac)	comment:AfCS Y2H protein 39306. Translated from nucleotide sequence.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2Q4quoSuPlUbD4QkiAkc9Hr9avI10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:62706197B247E5F4|rigid:0PTzKc5+D3Y4GsnPzzThdx31nvM	false	sufficient binding region:1585-1706	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYE6	uniprotkb:Q99N72	intact:EBI-644242|uniprotkb:O88317|uniprotkb:Q3TGE7|uniprotkb:Q3U6S5|uniprotkb:Q3UUF9|ensembl:ENSMUSP00000021609|ensembl:ENSMUSP00000137305	intact:EBI-641874	psi-mi:goga5_mouse(display_long)|uniprotkb:Golgin-84(gene name synonym)|uniprotkb:Protein Sumiko(gene name synonym)|uniprotkb:Protein Ret-II(gene name synonym)|uniprotkb:Golga5(gene name)|psi-mi:Golga5(display_short)|uniprotkb:Retii(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651891	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185933.1|refseq:NP_038775.1|refseq:XP_006515998.1|ensembl:ENSMUSG00000021192(gene)|ensembl:ENSMUST00000021609(transcript)|ensembl:ENSMUST00000179218(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000301"(retrograde transport, vesicle recycling within Golgi)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR019177	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:17417(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c7FH+gQxrIBgwdT419J+D6i+fKg10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:DB335E2D57677744|rigid:8FZWbuVBt9CNAjJSgJ8jfsiUYgA	false	sufficient binding region:283-562	sufficient binding region:5-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYE6	uniprotkb:Q99N72	intact:EBI-644242|uniprotkb:O88317|uniprotkb:Q3TGE7|uniprotkb:Q3U6S5|uniprotkb:Q3UUF9|ensembl:ENSMUSP00000021609|ensembl:ENSMUSP00000137305	intact:EBI-641874	psi-mi:goga5_mouse(display_long)|uniprotkb:Golgin-84(gene name synonym)|uniprotkb:Protein Sumiko(gene name synonym)|uniprotkb:Protein Ret-II(gene name synonym)|uniprotkb:Golga5(gene name)|psi-mi:Golga5(display_short)|uniprotkb:Retii(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651912	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185933.1|refseq:NP_038775.1|refseq:XP_006515998.1|ensembl:ENSMUSG00000021192(gene)|ensembl:ENSMUST00000021609(transcript)|ensembl:ENSMUST00000179218(transcript)|go:"GO:0000137"(Golgi cis cisterna)|go:"GO:0000138"(Golgi trans cisterna)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000301"(retrograde transport, vesicle recycling within Golgi)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005797"(Golgi medial cisterna)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0007030"(Golgi organization)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030663"(COPI-coated vesicle membrane)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031985"(Golgi cisterna)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0048193"(Golgi vesicle transport)|interpro:IPR019177	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:17417(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c7FH+gQxrIBgwdT419J+D6i+fKg10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:DCBA12535A1F0300|rigid:8FZWbuVBt9CNAjJSgJ8jfsiUYgA	false	sufficient binding region:381-580	sufficient binding region:5-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61990	uniprotkb:P26450	intact:EBI-644300|uniprotkb:Q61383|uniprotkb:Q62042|ensembl:ENSMUSP00000076294|ensembl:ENSMUSP00000077509	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:pcbp2_mouse(display_long)|uniprotkb:Alpha-CP2(gene name synonym)|uniprotkb:Putative heterogeneous nuclear ribonucleoprotein X(gene name synonym)|uniprotkb:CTBP(gene name synonym)|uniprotkb:Pcbp2(gene name)|psi-mi:Pcbp2(display_short)|uniprotkb:Cbp(gene name synonym)|uniprotkb:Hnrnpx(gene name synonym)|uniprotkb:Hnrpx(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652024	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001096635.1|refseq:NP_001096636.1|refseq:NP_035172.2|ensembl:ENSMUST00000077037(transcript)|ensembl:ENSMUST00000078404(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014069"(postsynaptic density)|go:"GO:0019899"(enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0039694"(viral RNA genome replication)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050687"(negative regulation of defense response to virus)|go:"GO:0051252"(regulation of RNA metabolic process)|go:"GO:0051607"(defense response to virus)|go:"GO:0075522"(IRES-dependent viral translational initiation)|go:"GO:1990829"(C-rich single-stranded DNA binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR036612|mint:Q61990|reactome:R-MMU-72163|reactome:R-MMU-72203|ensembl:ENSMUSG00000056851(gene)	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:7154(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:yU+DhZ+Fk16mrIjcAU4S2ttCOxo10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:CD66F1709DF81703|rigid:Zf+U3tfPQzlQLM6zUZGWbKF5La4	false	sufficient binding region:172-331	sufficient binding region:1-251	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z179	uniprotkb:P98083	intact:EBI-644352|uniprotkb:Q3UED9|uniprotkb:Q3UMD9|ensembl:ENSMUSP00000022945	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:shcbp_mouse(display_long)|uniprotkb:Protein expressed in activated lymphocytes(gene name synonym)|uniprotkb:SHC-binding protein(gene name synonym)|uniprotkb:Shcbp1(gene name)|psi-mi:Shcbp1(display_short)|uniprotkb:Pal(gene name synonym)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652034	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035499.1|ensembl:ENSMUSG00000022322(gene)|ensembl:ENSMUST00000022945(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0042169"(SH2 domain binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR039448	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:16731(secondary-ac)	-	-	caution:The prey construct contains 3 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MgcPGnEzLfUPCtS+m+6NJ4Yyr2k10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:D55D96FBDED03B48|rigid:J4QPdBrChXQdBwLoyulvqNyg/do	false	sufficient binding region:1-504	sufficient binding region:350-577	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z179	uniprotkb:P98083	intact:EBI-644352|uniprotkb:Q3UED9|uniprotkb:Q3UMD9|ensembl:ENSMUSP00000022945	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:shcbp_mouse(display_long)|uniprotkb:Protein expressed in activated lymphocytes(gene name synonym)|uniprotkb:SHC-binding protein(gene name synonym)|uniprotkb:Shcbp1(gene name)|psi-mi:Shcbp1(display_short)|uniprotkb:Pal(gene name synonym)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652045	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035499.1|ensembl:ENSMUSG00000022322(gene)|ensembl:ENSMUST00000022945(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0042169"(SH2 domain binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR039448	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:16731(secondary-ac)|afcs:6875(primary-reference)	-	-	caution:The prey construct contains 2 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MgcPGnEzLfUPCtS+m+6NJ4Yyr2k10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:0DF7983029509BE0|rigid:J4QPdBrChXQdBwLoyulvqNyg/do	false	sufficient binding region:1-417	sufficient binding region:350-577	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z179	uniprotkb:P98083	intact:EBI-644352|uniprotkb:Q3UED9|uniprotkb:Q3UMD9|ensembl:ENSMUSP00000022945	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:shcbp_mouse(display_long)|uniprotkb:Protein expressed in activated lymphocytes(gene name synonym)|uniprotkb:SHC-binding protein(gene name synonym)|uniprotkb:Shcbp1(gene name)|psi-mi:Shcbp1(display_short)|uniprotkb:Pal(gene name synonym)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652055	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035499.1|ensembl:ENSMUSG00000022322(gene)|ensembl:ENSMUST00000022945(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0042169"(SH2 domain binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR039448	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:16731(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MgcPGnEzLfUPCtS+m+6NJ4Yyr2k10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:F50D698F64008987|rigid:J4QPdBrChXQdBwLoyulvqNyg/do	false	sufficient binding region:9-416	sufficient binding region:350-577	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5RJI5	uniprotkb:P98083	intact:EBI-644361|uniprotkb:A7LH90|uniprotkb:A7LH91|uniprotkb:B7SRN7|uniprotkb:Q699J6|ensembl:ENSMUSP00000039517	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:brsk1_mouse(display_long)|uniprotkb:Sadb(gene name synonym)|uniprotkb:Brain-specific serine/threonine-protein kinase 1(gene name synonym)|uniprotkb:Gm1100(gene name synonym)|uniprotkb:Serine/threonine-protein kinase SAD-B(gene name synonym)|uniprotkb:Brsk1(gene name)|psi-mi:Brsk1(display_short)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652086	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003920.2|refseq:NP_001162044.1|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0051298"(centrosome duplication)|go:"GO:0090176"(microtubule cytoskeleton organization involved in establishment of planar polarity)|go:"GO:0099504"(synaptic vesicle cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0150034"(distal axon)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|rcsb pdb:5IRI|go:"GO:0050321"(tau-protein kinase activity)|ensembl:ENSMUSG00000035390(gene)|ensembl:ENSMUST00000048248(transcript)|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007095"(mitotic G2 DNA damage checkpoint signaling)|go:"GO:0007269"(neurotransmitter secretion)|go:"GO:0007409"(axonogenesis)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008306"(associative learning)|go:"GO:0009411"(response to UV)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030054"(cell junction)|go:"GO:0030182"(neuron differentiation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042149"(cellular response to glucose starvation)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0005524"(ATP binding)|go:"GO:0048812"(neuron projection morphogenesis)	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:35821(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hen6KZZ8RSmCcJInuHR6+FsFq2U10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:A4BD95B152D9E7B7|rigid:LvTJGZTof4E+vkmjiCDgbYIuT2o	false	sufficient binding region:269-373	sufficient binding region:350-577	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0S9	uniprotkb:E9PZQ0	intact:EBI-643030|ensembl:ENSMUSP00000030192	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:hint2_mouse(display_long)|uniprotkb:HINT-3(gene name synonym)|uniprotkb:Hint2(gene name)|psi-mi:Hint2(display_short)|uniprotkb:Histidine triad nucleotide-binding protein 2, mitochondrial(gene name synonym)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650560	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081147.1|ensembl:ENSMUSG00000028470(gene)|ensembl:ENSMUST00000030192(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0000166"(nucleotide binding)|go:"GO:0006694"(steroid biosynthetic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0016042"(lipid catabolic process)|go:"GO:0016787"(hydrolase activity)|go:"GO:2000757"(negative regulation of peptidyl-lysine acetylation)|interpro:IPR001310("Histidine triad (HIT) protein")|interpro:IPR011146(Histidine triad-like motif)|interpro:IPR019808|interpro:IPR036265|mint:Q9D0S9|reactome:R-MMU-9013405	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34657(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Gdlz2PAb1DzgAyTvfzwnLexPkho10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:9B8652ED6862CA38|rigid:SDsWWQFUCtD/Dh35HIkeNYB+IWM	false	sufficient binding region:2-144	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63001	uniprotkb:Q9QUI0	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	intact:EBI-643583|uniprotkb:O88336|ensembl:ENSMUSP00000007959	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:rhoa_mouse(display_long)|uniprotkb:Rhoa(gene name)|psi-mi:Rhoa(display_short)|uniprotkb:Arha(gene name synonym)|uniprotkb:Arha2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	refseq:NP_058082.2|refseq:NP_001300890.1|refseq:NP_001300891.1|ensembl:ENSMUST00000007959(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001822"(kidney development)|go:"GO:0001998"(angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure)|go:"GO:0002363"(alpha-beta T cell lineage commitment)|go:"GO:0003100"(regulation of systemic arterial blood pressure by endothelin)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007266"(Rho protein signal transduction)|ensembl:ENSMUSG00000007815(gene)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021795"(cerebral cortex cell migration)|go:"GO:0021861"(forebrain radial glial cell differentiation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030154"(cell differentiation)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0030496"(midbody)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0030521"(androgen receptor signaling pathway)|go:"GO:0009612"(response to mechanical stimulus)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0009749"(response to glucose)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031982"(vesicle)|go:"GO:0032154"(cleavage furrow)|go:"GO:0010812"(negative regulation of cell-substrate adhesion)|go:"GO:0032467"(positive regulation of cytokinesis)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033144"(negative regulation of intracellular steroid hormone receptor signaling pathway)|go:"GO:0033688"(regulation of osteoblast proliferation)|go:"GO:0034329"(cell junction assembly)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035385"(Roundabout signaling pathway)|go:"GO:0036089"(cleavage furrow formation)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0038027"(apolipoprotein A-I-mediated signaling pathway)|go:"GO:0042476"(odontogenesis)|go:"GO:0042493"|go:"GO:0042995"(cell projection)|go:"GO:0016020"(membrane)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043124"(negative regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043197"(dendritic spine)|go:"GO:0043200"(response to amino acid)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043296"(apical junction complex)|go:"GO:0043297"(apical junction assembly)|go:"GO:0016477"(cell migration)|go:"GO:0017022"(myosin binding)|go:"GO:0019003"(GDP binding)|go:"GO:0043366"(beta selection)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0044319"(wound healing, spreading of cells)|go:"GO:0045198"(establishment of epithelial cell apical/basal polarity)|go:"GO:0045471"(response to ethanol)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0070507"(regulation of microtubule cytoskeleton organization)|go:"GO:0045792"(negative regulation of cell size)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071803"(positive regulation of podosome assembly)|go:"GO:0071902"(positive regulation of protein serine/threonine kinase activity)|go:"GO:0071944"(cell periphery)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0090307"(mitotic spindle assembly)|go:"GO:0090324"(negative regulation of oxidative phosphorylation)|go:"GO:0097498"(endothelial tube lumen extension)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:1902766"(skeletal muscle satellite cell migration)|go:"GO:1903427"(negative regulation of reactive oxygen species biosynthetic process)|go:"GO:1903673"(mitotic cleavage furrow formation)|go:"GO:1904695"(positive regulation of vascular associated smooth muscle contraction)|go:"GO:0046039"(GTP metabolic process)|go:"GO:1904706"(negative regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904753"(negative regulation of vascular associated smooth muscle cell migration)|go:"GO:0046638"(positive regulation of alpha-beta T cell differentiation)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1905274"(regulation of modification of postsynaptic actin cytoskeleton)|go:"GO:1990869"(cellular response to chemokine)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|go:"GO:2000406"(positive regulation of T cell migration)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|go:"GO:0048812"(neuron projection morphogenesis)|mint:Q9QUI0|rcsb pdb:4F38|reactome:R-MMU-114604|reactome:R-MMU-193634|reactome:R-MMU-198203|reactome:R-MMU-209563|reactome:R-MMU-2173791|reactome:R-MMU-392451|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-4086400|reactome:R-MMU-416482|go:"GO:0050773"(regulation of dendrite development)|reactome:R-MMU-416550|reactome:R-MMU-416572|reactome:R-MMU-4420097|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5627117|reactome:R-MMU-5663220|reactome:R-MMU-5666185|reactome:R-MMU-5689896|go:"GO:0050919"(negative chemotaxis)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|reactome:R-MMU-6785631|go:"GO:0051384"(response to glucocorticoid)|reactome:R-MMU-6798695|go:"GO:0051496"(positive regulation of stress fiber assembly)|reactome:R-MMU-8849471|reactome:R-MMU-8980692|reactome:R-MMU-8985586|reactome:R-MMU-9013106|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0060193"(positive regulation of lipase activity)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061383"(trabecula morphogenesis)|dip:DIP-29984N	afcs:17758(primary-reference)|afcs:23265(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	rogid:HKBQaI187g5GnvTF9bilOaiTaXM10090	intact-crc:ADF9E606D26DA1A0|rigid:+X2Zj0hOaUKy1xoxULEoLTm+SwE	false	sufficient binding region:76-192	sufficient binding region:1-121	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01768	uniprotkb:Q99N72	intact:EBI-642573|ensembl:ENSMUSP00000021217|ensembl:ENSMUSP00000103476	intact:EBI-641874	psi-mi:ndkb_mouse(display_long)|uniprotkb:nm23-M2(gene name synonym)|uniprotkb:P18(gene name synonym)|uniprotkb:Nme2(gene name)|psi-mi:Nme2(display_short)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651308	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070997.1|refseq:NP_032731.1|ensembl:ENSMUSG00000020857(gene)|ensembl:ENSMUST00000021217(transcript)|ensembl:ENSMUST00000072566(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1901363"(heterocyclic compound binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q01768|reactome:R-MMU-499943|reactome:R-MMU-6798695	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:7069(secondary-ac)	-	-	caution:The prey construct contains 5 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AJ1Depmyy9zwTEUOZMRO7TKPd1k10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:786C5BC70F158FBB|rigid:UjjFKmQKWqXWOKBNx6oxoQYsE60	false	sufficient binding region:1-152	sufficient binding region:600-850	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYB1	uniprotkb:P70181	intact:EBI-645175|uniprotkb:Q8BMG5|ensembl:ENSMUSP00000041453	intact:EBI-645167|uniprotkb:O70335|uniprotkb:Q8JZY6|ensembl:ENSMUSP00000025800	psi-mi:clic4_mouse(display_long)|uniprotkb:Clic4(gene name)|psi-mi:Clic4(display_short)	psi-mi:pi51b_mouse(display_long)|uniprotkb:Pip5k1b(gene name)|psi-mi:Pip5k1b(display_short)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I beta(gene name synonym)|uniprotkb:68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653908	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038913.1|ensembl:ENSMUSG00000037242(gene)|ensembl:ENSMUST00000037099(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006821"(chloride transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002946(Intracellular chloride channel)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR030257|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:Q9QYB1	refseq:NP_032872.1|refseq:XP_006526826.1|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|reactome:R-MMU-1660499|reactome:R-MMU-201688|reactome:R-MMU-6811558|ensembl:ENSMUSG00000024867(gene)|ensembl:ENSMUST00000025800(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)	afcs:15015(primary-reference)|afcs:17522(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ghFdQmcUo1BuprnYT0mQRKnjgcw10090	rogid:heOUYCsDnkVH7SY/9uX3eoH0d+k10090	intact-crc:7181C2C47F4CCF33|rigid:hMkRHw6cBF2ee14irdYJVjx39r4	false	sufficient binding region:74-232	sufficient binding region:350-500	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1Q5	uniprotkb:P70181	intact:EBI-645184|ensembl:ENSMUSP00000007257	intact:EBI-645167|uniprotkb:O70335|uniprotkb:Q8JZY6|ensembl:ENSMUSP00000025800	psi-mi:clic1_mouse(display_long)|uniprotkb:Nuclear chloride ion channel 27(gene name synonym)|uniprotkb:Clic1(gene name)|psi-mi:Clic1(display_short)	psi-mi:pi51b_mouse(display_long)|uniprotkb:Pip5k1b(gene name)|psi-mi:Pip5k1b(display_short)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I beta(gene name synonym)|uniprotkb:68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653938	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_254279.1|ensembl:ENSMUSG00000007041(gene)|ensembl:ENSMUST00000007257(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006821"(chloride transport)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002946(Intracellular chloride channel)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR030259|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:Q9Z1Q5|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)	refseq:NP_032872.1|refseq:XP_006526826.1|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|reactome:R-MMU-1660499|reactome:R-MMU-201688|reactome:R-MMU-6811558|ensembl:ENSMUSG00000024867(gene)|ensembl:ENSMUST00000025800(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)	afcs:15015(primary-reference)|afcs:40286(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jYlg790vEs26tJ+6hGzV2KEGFQM10090	rogid:heOUYCsDnkVH7SY/9uX3eoH0d+k10090	intact-crc:FC716067F5B4FB31|rigid:HODvfMRR0Huc1VAmznvBRK6pjFQ	false	sufficient binding region:68-241	sufficient binding region:350-500	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88532	uniprotkb:P70392	intact:EBI-645485|uniprotkb:Q3TY30|uniprotkb:Q8BS85|uniprotkb:Q8CGG5|uniprotkb:Q91VZ0|uniprotkb:Q9CT34|ensembl:ENSMUSP00000118911	intact:EBI-645472|uniprotkb:Q3TYN3|uniprotkb:Q9QX51|ensembl:ENSMUSP00000116892	psi-mi:zfr_mouse(display_long)|uniprotkb:Zfr(gene name)|psi-mi:Zfr(display_short)	psi-mi:rgrf2_mouse(display_long)|uniprotkb:Grf2(gene name synonym)|uniprotkb:Ras guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:Rasgrf2(gene name)|psi-mi:Rasgrf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654452	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035897.2|ensembl:ENSMUSG00000022201(gene)|ensembl:ENSMUST00000122941(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003725"(double-stranded RNA binding)|go:"GO:0003727"(single-stranded RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0008270"(zinc ion binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR006561(DZF)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|interpro:IPR043519|mint:O88532	refseq:NP_033053.2|ensembl:ENSMUSG00000021708(gene)|ensembl:ENSMUST00000151408(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030744|interpro:IPR035899|interpro:IPR036964|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-5673001|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149	afcs:15164(primary-reference)|afcs:9598(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ncNwFUEUk0r2XotuXm/9Tt4iB5w10090	rogid:ot1s64p6SCwAmdb7PBYjuO4mLKk10090	intact-crc:42260BD8B8937016|rigid:GjgWNTyBduSkyNv45e0M1NJQAnM	false	sufficient binding region:614-778	sufficient binding region:150-445	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P26040	uniprotkb:P46662	intact:EBI-645505|uniprotkb:Q80ZT8|uniprotkb:Q9DCI1|ensembl:ENSMUSP00000063734	intact:EBI-644586|uniprotkb:Q8BR03|ensembl:ENSMUSP00000105536	psi-mi:ezri_mouse(display_long)|uniprotkb:Vil2(gene name synonym)|uniprotkb:p81(gene name synonym)|uniprotkb:Cytovillin(gene name synonym)|uniprotkb:Villin-2(gene name synonym)|uniprotkb:Ezr(gene name)|psi-mi:Ezr(display_short)	psi-mi:merl_mouse(display_long)|uniprotkb:Moesin-ezrin-radixin-like protein(gene name synonym)|uniprotkb:Neurofibromin-2(gene name synonym)|uniprotkb:Schwannomin(gene name synonym)|uniprotkb:Nf2(gene name)|psi-mi:Nf2(display_short)|uniprotkb:Nf-2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654485	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033536.2|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022614"(membrane to membrane docking)|go:"GO:0030175"(filopodium)|go:"GO:0030315"(T-tubule)|go:"GO:0030953"(astral microtubule organization)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032532"(regulation of microvillus length)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034629"|go:"GO:0035088"(establishment or maintenance of apical/basal cell polarity)|go:"GO:0036064"(ciliary basal body)|go:"GO:0040018"(positive regulation of multicellular organism growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043209"(myelin sheath)|go:"GO:0043622"(cortical microtubule organization)|go:"GO:0044297"(cell body)|go:"GO:0044393"(microspike)|go:"GO:0044548"(S100 protein binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0046847"(filopodium assembly)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050860"(negative regulation of T cell receptor signaling pathway)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051286"(cell tip)|go:"GO:0051660"(establishment of centrosome localization)|go:"GO:0061028"(establishment of endothelial barrier)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071944"(cell periphery)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0072697"(protein localization to cell cortex)|go:"GO:0097449"(astrocyte projection)|go:"GO:0097454"(Schwann cell microvillus)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098592"(cytoplasmic side of apical plasma membrane)|go:"GO:1902115"(regulation of organelle assembly)|go:"GO:1902896"(terminal web assembly)|go:"GO:1902966"(positive regulation of protein localization to early endosome)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903364"(positive regulation of cellular protein catabolic process)|go:"GO:1903753"(negative regulation of p38MAPK cascade)|go:"GO:2000643"(positive regulation of early endosome to late endosome transport)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|interpro:IPR008954(Moesin)|mint:P26040|reactome:R-MMU-373752|reactome:R-MMU-437239|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|ensembl:ENSMUSG00000052397(gene)|ensembl:ENSMUST00000064234(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001650"(fibrillar center)|go:"GO:0001726"(ruffle)|go:"GO:0001772"(immunological synapse)|go:"GO:0001931"(uropod)|go:"GO:0001951"(intestinal D-glucose absorption)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)	refseq:NP_035028.2|refseq:XP_006514633.1|ensembl:ENSMUSG00000009073(gene)|ensembl:ENSMUST00000109910(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005769"(early endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007398"(ectoderm development)|go:"GO:0007420"(brain development)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014013"(regulation of gliogenesis)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030175"(filopodium)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030864"(cortical actin cytoskeleton)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035330"(regulation of hippo signaling)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042127"(regulation of cell population proliferation)|interpro:IPR008954(Moesin)|interpro:IPR011174(Ezrin/radixin/moesin)|interpro:IPR011259(Ezrin/radixin/moesin, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR035963|interpro:IPR041789|mint:P46662|rcsb pdb:1ISN|rcsb pdb:3WA0|interpro:IPR000798(Ezrin/radixin/moesin ERM)|rcsb pdb:4P7I|rcsb pdb:4ZRK|reactome:R-MMU-2029482|reactome:R-MMU-5627123|go:"GO:0042532"(negative regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043005"(neuron projection)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0044297"(cell body)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0046426"(negative regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050767"(regulation of neurogenesis)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070306"(lens fiber cell differentiation)|go:"GO:0072091"(regulation of stem cell proliferation)|go:"GO:1900180"(regulation of protein localization to nucleus)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000299(Band 4.1, N-terminal)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|refseq:NP_001239179.1|refseq:NP_001239180.1|refseq:XP_011241971.1|refseq:NP_001239181.1|refseq:NP_001239182.1	afcs:16460(primary-reference)|afcs:15556(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PspmkV3JA32h1VGLkUgha3a59AA10090	rogid:xDzmqR+fx4dbxWKxBm5h+sWkzEw10090	intact-crc:E8FCD106AC3DF5BC|rigid:xFhpIOIPi5+EwOq/SOMLqbqojB4	false	sufficient binding region:229-477	sufficient binding region:1-255	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64378	uniprotkb:P27671	intact:EBI-492796|ensembl:ENSMUSP00000078382|ensembl:ENSMUSP00000110440|ensembl:ENSMUSP00000136245|ensembl:ENSMUSP00000156418	intact:EBI-645522|ensembl:ENSMUSP00000034912	psi-mi:fkbp5_mouse(display_long)|uniprotkb:FK506-binding protein 5(gene name synonym)|uniprotkb:51 kDa FK506-binding protein(gene name synonym)|uniprotkb:Rotamase(gene name synonym)|uniprotkb:Fkbp5(gene name)|psi-mi:Fkbp5(display_short)|uniprotkb:Fkbp51(gene name synonym)	psi-mi:rgrf1_mouse(display_long)|uniprotkb:Guanine nucleotide-releasing protein(gene name synonym)|uniprotkb:Ras-specific nucleotide exchange factor CDC25(gene name synonym)|uniprotkb:CDC25Mm(gene name synonym)|uniprotkb:Rasgrf1(gene name)|psi-mi:Rasgrf1(display_short)|uniprotkb:Cdc25(gene name synonym)|uniprotkb:Grf1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654496	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034350.1|ensembl:ENSMUSG00000024222(gene)|ensembl:ENSMUST00000079413(transcript)|ensembl:ENSMUST00000114792(transcript)|ensembl:ENSMUST00000177939(transcript)|ensembl:ENSMUST00000233102(transcript)|go:"GO:0000413"(protein peptidyl-prolyl isomerization)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005528"(FK506 binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0009617"(response to bacterium)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0061077"(chaperone-mediated protein folding)|interpro:IPR001179(Peptidyl-prolyl cis-trans isomerase, FKBP-type)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|interpro:IPR031210|mint:Q64378|reactome:R-MMU-3371497|reactome:R-MMU-8939211	refseq:NP_035375.1|dip:DIP-41194N|ensembl:ENSMUSG00000032356(gene)|ensembl:ENSMUST00000034912(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030426"(growth cone)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031267"(small GTPase binding)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035020"(regulation of Rac protein signal transduction)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0035254"(glutamate receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046578"(regulation of Ras protein signal transduction)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048167"(regulation of synaptic plasticity)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0097440"(apical dendrite)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030745|interpro:IPR035899|interpro:IPR036964|mint:P27671|rcsb pdb:2IJE|reactome:R-MMU-5673001	afcs:16651(primary-reference)|afcs:16022(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ihh8rfBDWGjo3gceXNl406Y50pU10090	rogid:Y3Wcc5F9IuroG15HLFXPQkL+2is10090	intact-crc:BB8572882009F12F|rigid:Z/dxTgsrquMMB2C3iF6Ua78yIQw	false	sufficient binding region:142-343	sufficient binding region:780-1011	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P19182	uniprotkb:P70181	intact:EBI-645541|uniprotkb:Q80XM4|uniprotkb:P21835|uniprotkb:P70228|ensembl:ENSMUSP00000001672	intact:EBI-645167|uniprotkb:O70335|uniprotkb:Q8JZY6|ensembl:ENSMUSP00000025800	psi-mi:ifrd1_mouse(display_long)|uniprotkb:Nerve growth factor-inducible protein PC4(gene name synonym)|uniprotkb:TPA-induced sequence 7(gene name synonym)|uniprotkb:Ifrd1(gene name)|psi-mi:Ifrd1(display_short)|uniprotkb:Tis7(gene name synonym)	psi-mi:pi51b_mouse(display_long)|uniprotkb:Pip5k1b(gene name)|psi-mi:Pip5k1b(display_short)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I beta(gene name synonym)|uniprotkb:68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654507	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038590.2|ensembl:ENSMUSG00000001627(gene)|ensembl:ENSMUST00000001672(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0014706"(striated muscle tissue development)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0042692"(muscle cell differentiation)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048671"(negative regulation of collateral sprouting)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR006921(Interferon-related protein conserved region)|interpro:IPR007701(Interferon-related developmental regulator)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039777	refseq:NP_032872.1|refseq:XP_006526826.1|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|reactome:R-MMU-1660499|reactome:R-MMU-201688|reactome:R-MMU-6811558|ensembl:ENSMUSG00000024867(gene)|ensembl:ENSMUST00000025800(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)	afcs:15015(primary-reference)|afcs:17276(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AHtvfKIU3BdCG1bygJcQerLEeJ410090	rogid:heOUYCsDnkVH7SY/9uX3eoH0d+k10090	intact-crc:A63B1E137DD4F001|rigid:uKF7YL4uwczXlFKSCdlU0Mh0nwM	false	sufficient binding region:5-228	sufficient binding region:350-500	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R1C7-1	uniprotkb:Q8CBW3	intact:EBI-645566|ensembl:ENSMUSP00000159339	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:q9r1c7-1(display_long)|uniprotkb:Prpf40a(gene name)|psi-mi:Prpf40a(display_short)|uniprotkb:Fbp11(gene name synonym)|uniprotkb:Fnbp3(gene name synonym)|uniprotkb:Formin-binding protein 11(gene name synonym)|uniprotkb:Formin-binding protein 3(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654517	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645554(fnbp3_mouse)|ensembl:ENSMUSG00000061136(gene)|ensembl:ENSMUST00000239398(transcript)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:17951(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:urpZDf+jd9lovL7obd2Y+a/lBCE10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:721688B36D57DF69|rigid:m15au6ZxGAnvLsppMsrczAhUFMo	false	sufficient binding region:1-257	sufficient binding region:306-417	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80Y14	uniprotkb:P70392	intact:EBI-645575|uniprotkb:Q3YML1|uniprotkb:Q9D6E9|ensembl:ENSMUSP00000021522	intact:EBI-645472|uniprotkb:Q3TYN3|uniprotkb:Q9QX51|ensembl:ENSMUSP00000116892	psi-mi:glrx5_mouse(display_long)|uniprotkb:Glrx5(gene name)|psi-mi:Glrx5(display_short)|uniprotkb:Monothiol glutaredoxin-5(gene name synonym)	psi-mi:rgrf2_mouse(display_long)|uniprotkb:Grf2(gene name synonym)|uniprotkb:Ras guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:Rasgrf2(gene name)|psi-mi:Rasgrf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654549	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082695.1|ensembl:ENSMUSG00000021102(gene)|ensembl:ENSMUST00000021522(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030425"(dendrite)|go:"GO:0043025"(neuronal cell body)|go:"GO:0046872"(metal ion binding)|go:"GO:0051537"(2 iron, 2 sulfur cluster binding)|go:"GO:0097573"(glutathione oxidoreductase activity)|go:"GO:0106034"(protein maturation by [2Fe-2S] cluster transfer)|go:"GO:0106035"(protein maturation by [4Fe-4S] cluster transfer)|interpro:IPR002109(Glutaredoxin)|interpro:IPR004480(Glutaredoxin-related protein)|interpro:IPR033658|interpro:IPR036249|reactome:R-MMU-1362409|go:"GO:0044571"([2Fe-2S] cluster assembly)	refseq:NP_033053.2|ensembl:ENSMUSG00000021708(gene)|ensembl:ENSMUST00000151408(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030744|interpro:IPR035899|interpro:IPR036964|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-5673001|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149	afcs:15164(primary-reference)|afcs:53137(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qKMGEJ5oYXg0R4AfyNqzR5pIg0o10090	rogid:ot1s64p6SCwAmdb7PBYjuO4mLKk10090	intact-crc:5538FEACD8B1389F|rigid:40cvuDkXOEFNJ+vtyhv2Rh1JEC0	false	sufficient binding region:2-152	sufficient binding region:150-445	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q640L3	uniprotkb:Q64096	intact:EBI-645632|uniprotkb:Q05BJ9|uniprotkb:Q922W9|uniprotkb:Q8C692|ensembl:ENSMUSP00000122966	intact:EBI-602123|uniprotkb:E9PV70	psi-mi:ccpg1_mouse(display_long)|uniprotkb:Ccpg1(gene name)|psi-mi:Ccpg1(display_short)	psi-mi:mcf2l_mouse(display_long)|uniprotkb:DBL's big sister(gene name synonym)|uniprotkb:MCF2-transforming sequence-like protein(gene name synonym)|uniprotkb:Mcf2l(gene name)|psi-mi:Mcf2l(display_short)|uniprotkb:Dbs(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654570	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001273473.1|refseq:NP_001273474.1|refseq:NP_001273475.1|refseq:NP_001107800.1|refseq:NP_082457.3|ensembl:ENSMUSG00000034563(gene)|ensembl:ENSMUST00000150826(transcript)|go:"GO:0007049"(cell cycle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0045787"(positive regulation of cell cycle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:2001106"(regulation of Rho guanyl-nucleotide exchange factor activity)|interpro:IPR033588	mint:Q64096|dip:DIP-34544N|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005545"(1-phosphatidylinositol binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030027"(lamellipodium)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002017(Spectrin repeat)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR018159|interpro:IPR035532|interpro:IPR035534|interpro:IPR035899|interpro:IPR036028|interpro:IPR036865|rcsb pdb:1KZ7|rcsb pdb:1KZG|rcsb pdb:1LB1|rcsb pdb:1RJ2|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013408	afcs:13028(primary-reference)|afcs:53163(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c+tgIM7ZyawbjGFvrOLIiZamGCs10090	rogid:nIIFS7gLKii0O6GIj7BzA7zC9Rs10090	intact-crc:5E132E33C6CD5629|rigid:AOa8BKfDEAp/382xuwOxa4kjl0w	false	sufficient binding region:307-474	sufficient binding region:398-600	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CBW3	uniprotkb:B1AZP2	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	intact:EBI-645637|uniprotkb:B1AZP3|uniprotkb:Q3KQQ8|uniprotkb:Q6PD44|uniprotkb:Q6XBF1|uniprotkb:Q80TN3|uniprotkb:Q8R3U9|uniprotkb:B7ZNS1|ensembl:ENSMUSP00000126980	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:dlgp4_mouse(display_long)|uniprotkb:Kiaa0964(gene name synonym)|uniprotkb:Sapap4(gene name synonym)|uniprotkb:SAP90/PSD-95-associated protein 4(gene name synonym)|uniprotkb:PSD-95/SAP90-binding protein 4(gene name synonym)|uniprotkb:Dlgap4(gene name)|psi-mi:Dlgap4(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654581	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	refseq:NP_001035952.1|refseq:NP_666240.4|refseq:NP_001264115.1|refseq:NP_001035953.1|refseq:NP_001264116.1|refseq:XP_006499403.1|ensembl:ENSMUSG00000061689(gene)|ensembl:ENSMUST00000169464(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0023052"(signaling)|go:"GO:0030425"(dendrite)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045202"(synapse)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0098962"(regulation of postsynaptic neurotransmitter receptor activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098981"(cholinergic synapse)|go:"GO:0099572"(postsynaptic specialization)|interpro:IPR005026(Guanylate-kinase-associated protein)|interpro:IPR030527|mint:B1AZP2|reactome:R-MMU-6794361	afcs:33872(primary-reference)|afcs:53164(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rogid:Ksjp5jiwjvzSymdyt1kSs8I+1pE10090	intact-crc:69D603826B85F5E0|rigid:bV8hDYuI2dxYcYSiNbKu3zeGkoI	false	sufficient binding region:402-480	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QX11	uniprotkb:Q9QXJ2	intact:EBI-646678|uniprotkb:Q76MU4|uniprotkb:O88817|ensembl:ENSMUSP00000101912	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:cyh1_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 1(gene name synonym)|uniprotkb:SEC7 homolog A(gene name synonym)|uniprotkb:Cyth1(gene name)|psi-mi:Cyth1(display_short)|uniprotkb:Pscd1(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656752	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106169.1|refseq:NP_035310.2|ensembl:ENSMUSG00000017132(gene)|ensembl:ENSMUST00000106305(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|reactome:R-MMU-6811438	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:16612(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Cl1DtnqE/FsMVxm9QZko6yMX+Ds10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:B281EA015D380706|rigid:rGlsyXt/GPB/6iegy4WEV4ydZto	false	sufficient binding region:1-233	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657064	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:0F76800E3E7B1D80|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:85-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657074	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:AA9CB44F4BED91A4|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:113-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657084	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:51769BF12EDAF3B8|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:121-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:ECB6BDD58D2B704E|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:142-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657114	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:291D9C186C5474F1|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:146-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657134	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:D3A3D71DFE532F8F|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:152-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657144	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:D74ACC13B44D6580|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:159-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657154	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:6888111D02448803|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:165-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657174	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:1889A909422834D3|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:187-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657184	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:010C9860099F014A|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:204-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657204	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:BB733ADB02B89FA4|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:215-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657214	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:FC0D57FA334E472C|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:262-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657233	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:B429BF573A7465A4|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:317-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657243	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:707CC87CD7A344C8|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:326-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657253	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:763D1A0573DD7C03|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:361-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657263	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:492870CD00A523C2|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:371-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDB0	uniprotkb:P63085	intact:EBI-646209|uniprotkb:O08606|uniprotkb:Q75PY0|uniprotkb:Q9D893|ensembl:ENSMUSP00000143508	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk2_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 2(gene name synonym)|uniprotkb:Mknk2(gene name)|psi-mi:Mknk2(display_short)|uniprotkb:Mnk2(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657273	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067437.2|refseq:XP_006513379.1|refseq:XP_017169313.1|ensembl:ENSMUSG00000020190(gene)|ensembl:ENSMUST00000200082(transcript)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006417"(regulation of translation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0016605"(PML body)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0030097"(hemopoiesis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071243"(cellular response to arsenic-containing substance)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:17112(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7Njh80Vh6LeOKkd+GsKISXpkRJk10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:79E82167D9E95A82|rigid:7GyMWb6Jl7Bi2Php6WRBeK1edK0	false	sufficient binding region:396-412	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657314	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:025111B89A91D748|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:68-280	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657324	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:504D847891E3C60B|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:97-280	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657334	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:FF0D0FD198F60AFD|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:131-280	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657344	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:6A294BDB39107DA0|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:143-279	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657354	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:CB04F8E1FD678817|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:155-280	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657364	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:D1000379CFAF4962|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:167-280	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:P42227	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657384	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:4470229A70C26A7C|rigid:ucK29nqKVIDUD++ayTPBUi9Ja60	false	sufficient binding region:183-280	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03172	uniprotkb:P63085	intact:EBI-646850	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:zep1_mouse(display_long)|uniprotkb:Transcription factor alphaA-CRYBP1(gene name synonym)|uniprotkb:Alpha A-crystallin-binding protein I(gene name synonym)|uniprotkb:Alpha A-crystallin-binding protein 1(gene name synonym)|uniprotkb:Hivep1(gene name)|psi-mi:Hivep1(display_short)|uniprotkb:Cryabp1(gene name synonym)|uniprotkb:Znf40(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657484	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR034729|interpro:IPR036236|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:14118(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2aZZR3UcsEIiv2Hn0nBPw4ih2F010090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:002160FBC51EF86A|rigid:zmW3Wv69nOvYYwKxQTDjKSsjdHk	false	sufficient binding region:1382-1674	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z2B9	uniprotkb:P63085	intact:EBI-412887|uniprotkb:Q91X18|uniprotkb:Q3U3M8|ensembl:ENSMUSP00000159422	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:ks6a4_mouse(display_long)|uniprotkb:Rps6ka4(gene name)|psi-mi:Rps6ka4(display_short)|uniprotkb:Msk2(gene name synonym)|uniprotkb:Nuclear mitogen- and stress-activated protein kinase 2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 4(gene name synonym)|uniprotkb:RSK-like protein kinase(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657524	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064308.2|ensembl:ENSMUSG00000118668(gene)|ensembl:ENSMUST00000239527(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR037714|go:"GO:0033129"(positive regulation of histone phosphorylation)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:18366(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0KS9aQPZHUihMySfnnDnLkZl5dQ10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:A47B142611F683B8|rigid:KEg9r3dkdMgS8ch+RiEGTDQ44W0	false	sufficient binding region:315-773	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z2B9	uniprotkb:P63085	intact:EBI-412887|uniprotkb:Q91X18|uniprotkb:Q3U3M8|ensembl:ENSMUSP00000159422	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:ks6a4_mouse(display_long)|uniprotkb:Rps6ka4(gene name)|psi-mi:Rps6ka4(display_short)|uniprotkb:Msk2(gene name synonym)|uniprotkb:Nuclear mitogen- and stress-activated protein kinase 2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 4(gene name synonym)|uniprotkb:RSK-like protein kinase(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657544	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064308.2|ensembl:ENSMUSG00000118668(gene)|ensembl:ENSMUST00000239527(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR037714|go:"GO:0033129"(positive regulation of histone phosphorylation)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:18366(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0KS9aQPZHUihMySfnnDnLkZl5dQ10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:BA07DADE008ED61E|rigid:KEg9r3dkdMgS8ch+RiEGTDQ44W0	false	sufficient binding region:581-773	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z104	uniprotkb:P39428	intact:EBI-646920|uniprotkb:Q9NSF7|uniprotkb:Q9NSF8|ensembl:ENSMUSP00000020454|ensembl:ENSMUSP00000100960|ensembl:ENSMUSP00000100961|ensembl:ENSMUSP00000128807	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:hm20b_mouse(display_long)|uniprotkb:HMG box-containing protein 20B(gene name synonym)|uniprotkb:Structural DNA-binding protein BRAF35(gene name synonym)|uniprotkb:BRCA2-associated factor 35(gene name synonym)|uniprotkb:Hmg20b(gene name)|psi-mi:Hmg20b(display_short)|uniprotkb:Braf35(gene name synonym)|uniprotkb:Hmgx2(gene name synonym)|uniprotkb:Smarce1r(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657595	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156637.1|refseq:NP_001156638.1|refseq:NP_034570.1|ensembl:ENSMUSG00000020232(gene)|ensembl:ENSMUST00000020454(transcript)|ensembl:ENSMUST00000105323(transcript)|ensembl:ENSMUST00000105324(transcript)|ensembl:ENSMUST00000167481(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002111"(BRCA2-BRAF35 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|rcsb pdb:2CRJ|reactome:R-MMU-3214815|reactome:R-MMU-983231	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:23603(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FqfdR1RK6T2N0BYXOD5lfPay8AY10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:D14B4082223628BD|rigid:rmQtlbizNascaTRbPsASpl0MCXI	false	sufficient binding region:19-317	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6YIY0	uniprotkb:P42227	intact:EBI-646936	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:q6yiy0_mouse(display_long)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657625	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000840(Gamma-retroviral matrix, N-terminal)|interpro:IPR003036(Core shell protein Gag P30)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|interpro:IPR036946|go:"GO:0003676"(nucleic acid binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0019068"(virion assembly)|interpro:IPR002079(Gag polyprotein, inner coat protein p12)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:58152(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:zISceMvgZRzljc/e1euMwWHweDU10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:99345761A52EC9B9|rigid:WDWOmIK19+jsdZ3qXmBuyj88cCo	false	sufficient binding region:139-506	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6YIY0	uniprotkb:P42227	intact:EBI-646936	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:q6yiy0_mouse(display_long)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657635	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000840(Gamma-retroviral matrix, N-terminal)|interpro:IPR003036(Core shell protein Gag P30)|interpro:IPR008919(Retrovirus capsid, N-terminal core)|interpro:IPR010999(Retroviral matrix, N-terminal)|interpro:IPR001878(Zinc finger, CCHC-type)|interpro:IPR036875|interpro:IPR036946|go:"GO:0003676"(nucleic acid binding)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016020"(membrane)|go:"GO:0019068"(virion assembly)|interpro:IPR002079(Gag polyprotein, inner coat protein p12)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:58152(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:zISceMvgZRzljc/e1euMwWHweDU10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:AA634445E66F43E4|rigid:WDWOmIK19+jsdZ3qXmBuyj88cCo	false	sufficient binding region:367-508	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80VH0	uniprotkb:P42227	intact:EBI-646949|uniprotkb:E9QMV3|uniprotkb:Q3U178|uniprotkb:Q8BRV6|uniprotkb:Q8BRY8|ensembl:ENSMUSP00000035484	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:bank1_mouse(display_long)|uniprotkb:Protein AVIEF(gene name synonym)|uniprotkb:Bank1(gene name)|psi-mi:Bank1(display_short)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657645	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028522.2|ensembl:ENSMUSG00000037922(gene)|ensembl:ENSMUST00000041577(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|go:"GO:0051898"(negative regulation of protein kinase B signaling)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:58142(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ax47+UutyTUB1w4HpZlyod6A5rw10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:560460EBDCAC100B|rigid:CWTGSnrjeOxmA/csbe5a/xMDmcE	false	sufficient binding region:13-338	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80VH0	uniprotkb:P42227	intact:EBI-646949|uniprotkb:E9QMV3|uniprotkb:Q3U178|uniprotkb:Q8BRV6|uniprotkb:Q8BRY8|ensembl:ENSMUSP00000035484	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:bank1_mouse(display_long)|uniprotkb:Protein AVIEF(gene name synonym)|uniprotkb:Bank1(gene name)|psi-mi:Bank1(display_short)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657655	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028522.2|ensembl:ENSMUSG00000037922(gene)|ensembl:ENSMUST00000041577(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|go:"GO:0051898"(negative regulation of protein kinase B signaling)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:58142(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ax47+UutyTUB1w4HpZlyod6A5rw10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:13C39AE0E7261FE8|rigid:CWTGSnrjeOxmA/csbe5a/xMDmcE	false	sufficient binding region:122-332	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80VH0	uniprotkb:P42227	intact:EBI-646949|uniprotkb:E9QMV3|uniprotkb:Q3U178|uniprotkb:Q8BRV6|uniprotkb:Q8BRY8|ensembl:ENSMUSP00000035484	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:bank1_mouse(display_long)|uniprotkb:Protein AVIEF(gene name synonym)|uniprotkb:Bank1(gene name)|psi-mi:Bank1(display_short)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657665	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028522.2|ensembl:ENSMUSG00000037922(gene)|ensembl:ENSMUST00000041577(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|go:"GO:0051898"(negative regulation of protein kinase B signaling)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:58142(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ax47+UutyTUB1w4HpZlyod6A5rw10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:7FBC3A35CE85C7DA|rigid:CWTGSnrjeOxmA/csbe5a/xMDmcE	false	sufficient binding region:169-344	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80VH0	uniprotkb:P42227	intact:EBI-646949|uniprotkb:E9QMV3|uniprotkb:Q3U178|uniprotkb:Q8BRV6|uniprotkb:Q8BRY8|ensembl:ENSMUSP00000035484	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:bank1_mouse(display_long)|uniprotkb:Protein AVIEF(gene name synonym)|uniprotkb:Bank1(gene name)|psi-mi:Bank1(display_short)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657675	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028522.2|ensembl:ENSMUSG00000037922(gene)|ensembl:ENSMUST00000041577(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|go:"GO:0051898"(negative regulation of protein kinase B signaling)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:58142(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ax47+UutyTUB1w4HpZlyod6A5rw10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:FD9ABC430547CAD7|rigid:CWTGSnrjeOxmA/csbe5a/xMDmcE	false	sufficient binding region:178-332	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R332-1	uniprotkb:P39428	intact:EBI-646962|ensembl:ENSMUSP00000038716	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:q8r332-1(display_long)|uniprotkb:Nup58(gene name)|psi-mi:Nup58(display_short)|uniprotkb:58 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin-like protein 1(gene name synonym)|uniprotkb:Nupl1(gene name synonym)|uniprotkb:p58(isoform synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657685	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646954(nupl1_mouse)|ensembl:ENSMUSG00000114797(gene)|ensembl:ENSMUST00000041905(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58144(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YLsFTqH5EgU83bQb2r7ap3NDQac10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:47E4DD27C148B092|rigid:a7UIAoebyyB4QafaHfvo+kaNBJI	false	sufficient binding region:35-328	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P50247	uniprotkb:P39428	intact:EBI-646982|uniprotkb:Q91WF1|ensembl:ENSMUSP00000061851|ensembl:ENSMUSP00000127198	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:sahh_mouse(display_long)|uniprotkb:S-adenosyl-L-homocysteine hydrolase(gene name synonym)|uniprotkb:Liver copper-binding protein(gene name synonym)|uniprotkb:CUBP(gene name synonym)|uniprotkb:Ahcy(gene name)|psi-mi:Ahcy(display_short)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657705	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057870.3|refseq:NP_001291457.1|ensembl:ENSMUSG00000027597(gene)|ensembl:ENSMUSG00000048087(gene)|ensembl:ENSMUST00000054607(transcript)|ensembl:ENSMUST00000059524(transcript)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0004013"(adenosylhomocysteinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0019510"(S-adenosylhomocysteine catabolic process)|go:"GO:0030554"(adenyl nucleotide binding)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0042470"(melanosome)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0051287"(NAD binding)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:P50247|rcsb pdb:5AXA|rcsb pdb:5AXB|rcsb pdb:5AXC|reactome:R-MMU-156581|reactome:R-MMU-1614635|rcsb pdb:5AXD	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:17645(secondary-ac)	-	-	caution:The prey construct contains 11 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3huaZIY/NrWyXH/kTaMriwT35A410090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:BA552E9368FA04CE|rigid:cQc0LJoKQ3XWrfh/yWULGYUEPB0	false	sufficient binding region:2-186	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DC33	uniprotkb:P39428	intact:EBI-646990|uniprotkb:Q8BSK1|uniprotkb:Q8C3C1|uniprotkb:Q8CAA0|uniprotkb:Q9CYG2|uniprotkb:Q3LSF9|uniprotkb:Q6NV87|ensembl:ENSMUSP00000034879|ensembl:ENSMUSP00000149698	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:hm20a_mouse(display_long)|uniprotkb:HMG domain-containing protein HMGX1(gene name synonym)|uniprotkb:HMG box-containing protein 20A(gene name synonym)|uniprotkb:Inhibitor of BRAF35(gene name synonym)|uniprotkb:Hmg20a(gene name)|psi-mi:Hmg20a(display_short)|uniprotkb:Ibraf(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657745	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080088.1|refseq:XP_006511431.1|ensembl:ENSMUSG00000032329(gene)|ensembl:ENSMUST00000034879(transcript)|ensembl:ENSMUST00000215269(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q9DC33	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:30787(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uPs2AMRugDm5M7mcJY7852zxQOo10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:36CB0CA783BE6F6E|rigid:VenAq/JFPNL0H1+D0BRJs6V86tI	false	sufficient binding region:124-346	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80VH0	uniprotkb:P39428	intact:EBI-646949|uniprotkb:E9QMV3|uniprotkb:Q3U178|uniprotkb:Q8BRV6|uniprotkb:Q8BRY8|ensembl:ENSMUSP00000035484	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:bank1_mouse(display_long)|uniprotkb:Protein AVIEF(gene name synonym)|uniprotkb:Bank1(gene name)|psi-mi:Bank1(display_short)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657755	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028522.2|ensembl:ENSMUSG00000037922(gene)|ensembl:ENSMUST00000041577(transcript)|go:"GO:0002020"(protease binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0009617"(response to bacterium)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050869"(negative regulation of B cell activation)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000157(Toll-Interleukin receptor)|interpro:IPR017893|interpro:IPR035897|interpro:IPR041340|go:"GO:0051898"(negative regulation of protein kinase B signaling)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58142(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ax47+UutyTUB1w4HpZlyod6A5rw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:2B0E464803E00336|rigid:qP3unQfjxFkf8YEPo/OdgJh/HFo	false	sufficient binding region:122-332	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R332-1	uniprotkb:P63085	intact:EBI-646962|ensembl:ENSMUSP00000038716	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:q8r332-1(display_long)|uniprotkb:Nup58(gene name)|psi-mi:Nup58(display_short)|uniprotkb:58 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin-like protein 1(gene name synonym)|uniprotkb:Nupl1(gene name synonym)|uniprotkb:p58(isoform synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657764	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646954(nupl1_mouse)|ensembl:ENSMUSG00000114797(gene)|ensembl:ENSMUST00000041905(transcript)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:58144(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YLsFTqH5EgU83bQb2r7ap3NDQac10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:630A7550BE152438|rigid:z6iLQ56uOLYZNksid9rboLvJxcI	false	sufficient binding region:310-587	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R332-1	uniprotkb:P63085	intact:EBI-646962|ensembl:ENSMUSP00000038716	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:q8r332-1(display_long)|uniprotkb:Nup58(gene name)|psi-mi:Nup58(display_short)|uniprotkb:58 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin-like protein 1(gene name synonym)|uniprotkb:Nupl1(gene name synonym)|uniprotkb:p58(isoform synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657774	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646954(nupl1_mouse)|ensembl:ENSMUSG00000114797(gene)|ensembl:ENSMUST00000041905(transcript)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:58144(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YLsFTqH5EgU83bQb2r7ap3NDQac10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:AF5549E5F5305E1D|rigid:z6iLQ56uOLYZNksid9rboLvJxcI	false	sufficient binding region:355-587	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R332-1	uniprotkb:P63085	intact:EBI-646962|ensembl:ENSMUSP00000038716	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:q8r332-1(display_long)|uniprotkb:Nup58(gene name)|psi-mi:Nup58(display_short)|uniprotkb:58 kDa nucleoporin(gene name synonym)|uniprotkb:Nucleoporin-like protein 1(gene name synonym)|uniprotkb:Nupl1(gene name synonym)|uniprotkb:p58(isoform synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657784	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646954(nupl1_mouse)|ensembl:ENSMUSG00000114797(gene)|ensembl:ENSMUST00000041905(transcript)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:58144(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YLsFTqH5EgU83bQb2r7ap3NDQac10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:35A6E56916F11BF5|rigid:z6iLQ56uOLYZNksid9rboLvJxcI	false	sufficient binding region:359-530	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01768	uniprotkb:O88351	intact:EBI-642573|ensembl:ENSMUSP00000021217|ensembl:ENSMUSP00000103476	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:ndkb_mouse(display_long)|uniprotkb:nm23-M2(gene name synonym)|uniprotkb:P18(gene name synonym)|uniprotkb:Nme2(gene name)|psi-mi:Nme2(display_short)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657884	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070997.1|refseq:NP_032731.1|ensembl:ENSMUSG00000020857(gene)|ensembl:ENSMUST00000021217(transcript)|ensembl:ENSMUST00000072566(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1901363"(heterocyclic compound binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q01768|reactome:R-MMU-499943|reactome:R-MMU-6798695	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:7069(secondary-ac)|afcs:31405(primary-reference)	-	-	caution:The prey construct contains 18 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AJ1Depmyy9zwTEUOZMRO7TKPd1k10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:1A47F5BD1EC6C383|rigid:JakbgN7AsQQDoaH81hr6stZGKyk	false	sufficient binding region:1-152	sufficient binding region:490-735	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6P5D4	uniprotkb:P63085	intact:EBI-647072|uniprotkb:Q6A030|ensembl:ENSMUSP00000038674|ensembl:ENSMUSP00000112602	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:cp135_mouse(display_long)|uniprotkb:Centrosomal protein 4(gene name synonym)|uniprotkb:Cep135(gene name)|psi-mi:Cep135(display_short)|uniprotkb:Cep4(gene name synonym)|uniprotkb:Kiaa0635(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657894	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_950197.1|refseq:XP_006535086.1|ensembl:ENSMUST00000049060(transcript)|ensembl:ENSMUST00000121979(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0007099"(centriole replication)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:1902857"(positive regulation of non-motile cilium assembly)|go:"GO:1904951"(positive regulation of establishment of protein localization)|interpro:IPR026732|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|ensembl:ENSMUSG00000036403(gene)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:58150(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bnLzvANWuZvXXiue5WVyCKUIWkA10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:C999A10BBC20B8F3|rigid:YP40aNTdlsNHKMgpZxHKLbykOaA	false	sufficient binding region:1009-1140	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D318	uniprotkb:P63085	intact:EBI-647080	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:q9d318_mouse(display_long)|uniprotkb:Gramd3(gene name)|psi-mi:Gramd3(display_short)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657904	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004182(GRAM)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0016021"(integral component of membrane)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:58151(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jhUF4eqRzuKzdcUWIT8JF3IpwNg10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:83DD641203FDD059|rigid:nt2v4ZsawVqlVdOp2xyWC4Kq4Dc	false	sufficient binding region:115-481	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D318	uniprotkb:P63085	intact:EBI-647080	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:q9d318_mouse(display_long)|uniprotkb:Gramd3(gene name)|psi-mi:Gramd3(display_short)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657914	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR004182(GRAM)|interpro:IPR011993(Pleckstrin homology-type)|go:"GO:0016021"(integral component of membrane)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:58151(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jhUF4eqRzuKzdcUWIT8JF3IpwNg10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:77D2FB03A5EA5181|rigid:nt2v4ZsawVqlVdOp2xyWC4Kq4Dc	false	sufficient binding region:185-478	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63085	intact:EBI-687980	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	afcs:58422	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:mll2_mouse_protein(display_short)|psi-mi:EBI-687980(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688504	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	-	afcs:17112(primary-reference)|afcs:58122(primary-reference)|afcs:58122(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"similar to human Myeloid/lymphoid or mixed-lineage leukemia protein 2 (90%)"|comment:AfCS Y2H protein 58122. Translated from nucleotide sequence.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rogid:F0VCeE8RmWjHjgm8TR6EQ1iaSwQ10090	intact-crc:35B3175F9627D9D8|rigid:ZtXd7cPNXoTd/cctnARcSfwUiXQ	false	sufficient binding region:1-358	sufficient binding region:1100-1389	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63085	intact:EBI-687980	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	afcs:58422	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:mll2_mouse_protein(display_short)|psi-mi:EBI-687980(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688515	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	-	afcs:17112(primary-reference)|afcs:58122(primary-reference)|afcs:58122(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"similar to human Myeloid/lymphoid or mixed-lineage leukemia protein 2 (90%)"|comment:AfCS Y2H protein 58122. Translated from nucleotide sequence.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rogid:F0VCeE8RmWjHjgm8TR6EQ1iaSwQ10090	intact-crc:8BF02F01003F8333|rigid:ZtXd7cPNXoTd/cctnARcSfwUiXQ	false	sufficient binding region:1-358	sufficient binding region:1112-1336	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63085	intact:EBI-687980	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	afcs:58422	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:mll2_mouse_protein(display_short)|psi-mi:EBI-687980(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688526	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	-	afcs:17112(primary-reference)|afcs:58122(primary-reference)|afcs:58122(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"similar to human Myeloid/lymphoid or mixed-lineage leukemia protein 2 (90%)"|comment:AfCS Y2H protein 58122. Translated from nucleotide sequence.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	rogid:F0VCeE8RmWjHjgm8TR6EQ1iaSwQ10090	intact-crc:3B1E44BBE90143CF|rigid:ZtXd7cPNXoTd/cctnARcSfwUiXQ	false	sufficient binding region:1-358	sufficient binding region:1155-1315	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1A1	uniprotkb:Q60591	intact:EBI-308964|ensembl:ENSMUSP00000067867	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:q9z1a1_mouse(display_long)|uniprotkb:Tfg(gene name)|psi-mi:Tfg(display_short)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650982	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062652.1|ensembl:ENSMUSG00000022757(gene)|ensembl:ENSMUST00000065515(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0070971"(endoplasmic reticulum exit site)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR033512|interpro:IPR034857|mint:Q9Z1A1|reactome:R-MMU-204005|refseq:XP_006522043.1	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	afcs:53032(primary-reference)|afcs:18200(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1FKAyK5RtgkNH6VHJOpn+Xej1q810090	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	intact-crc:D69823E7DAA34B0C|rigid:243RToxu9zn88fbPznmek1Kx/BI	false	sufficient binding region:276-397	sufficient binding region:200-420	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CX30	uniprotkb:P97428	intact:EBI-643179|ensembl:ENSMUSP00000032809|uniprotkb:Q32M25|uniprotkb:Q3UXJ5	intact:EBI-643424|uniprotkb:O09091|uniprotkb:P97420|uniprotkb:Q80V16|ensembl:ENSMUSP00000027748	psi-mi:yif1b_mouse(display_long)|uniprotkb:YIP1-interacting factor homolog B(gene name synonym)|uniprotkb:Yif1b(gene name)|psi-mi:Yif1b(display_short)	psi-mi:rgs16_mouse(display_long)|uniprotkb:Retinally abundant regulator of G-protein signaling(gene name synonym)|uniprotkb:Retinal-specific RGS(gene name synonym)|uniprotkb:A28-RGS14P(gene name synonym)|uniprotkb:Rgs16(gene name)|psi-mi:Rgs16(display_short)|uniprotkb:Rgsr(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651012	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103671.1|refseq:NP_084163.2|ensembl:ENSMUSG00000030588(gene)|ensembl:ENSMUST00000032809(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|interpro:IPR005578(Hrf1)	refseq:NP_035397.2|ensembl:ENSMUSG00000026475(gene)|ensembl:ENSMUST00000027748(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045121"(membrane raft)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR036305|rcsb pdb:3C7K|rcsb pdb:3C7L|reactome:R-MMU-416476|reactome:R-MMU-418594|reactome:R-MMU-418597|go:"GO:0031224"(intrinsic component of membrane)|dip:DIP-29922N	afcs:13046(primary-reference)|afcs:3600(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:wUT7xFZMlSydfxqnCChePMSJeLU10090	rogid:buK6Jft9nH+59HSZtxpcY9e14hU10090	intact-crc:EA02C8614D9A72BC|rigid:02zaer9bpcmiA4Zc31R4aai/9Ew	false	sufficient binding region:20-311	sufficient binding region:1-40	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CG48	uniprotkb:Q8BH43	intact:EBI-643436|uniprotkb:Q52KE9|uniprotkb:Q61076|uniprotkb:Q9CS17|uniprotkb:Q9CSD8|ensembl:ENSMUSP00000099979|ensembl:ENSMUSP00000113940	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:smc2_mouse(display_long)|uniprotkb:Chromosome-associated protein E(gene name synonym)|uniprotkb:XCAP-E homolog(gene name synonym)|uniprotkb:FGF-inducible protein 16(gene name synonym)|uniprotkb:Smc2(gene name)|psi-mi:Smc2(display_short)|uniprotkb:Cape(gene name synonym)|uniprotkb:Fin16(gene name synonym)|uniprotkb:Smc2l1(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651023	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032043.3|refseq:NP_001288341.1|ensembl:ENSMUSG00000028312(gene)|ensembl:ENSMUST00000102915(transcript)|ensembl:ENSMUST00000117280(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027120|interpro:IPR027417|interpro:IPR036277|mint:Q8CG48|rcsb pdb:3L51|reactome:R-MMU-2299718|reactome:R-MMU-2514853	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:14330(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:A8IwiTQIuTw7BA9PQ5ZTSmxFIQA10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:1C7BE60F9AF31784|rigid:QCygLMCh/xAiHLcCmBB0gpuF9fY	false	sufficient binding region:801-979	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CG48	uniprotkb:Q8BH43	intact:EBI-643436|uniprotkb:Q52KE9|uniprotkb:Q61076|uniprotkb:Q9CS17|uniprotkb:Q9CSD8|ensembl:ENSMUSP00000099979|ensembl:ENSMUSP00000113940	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:smc2_mouse(display_long)|uniprotkb:Chromosome-associated protein E(gene name synonym)|uniprotkb:XCAP-E homolog(gene name synonym)|uniprotkb:FGF-inducible protein 16(gene name synonym)|uniprotkb:Smc2(gene name)|psi-mi:Smc2(display_short)|uniprotkb:Cape(gene name synonym)|uniprotkb:Fin16(gene name synonym)|uniprotkb:Smc2l1(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651043	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032043.3|refseq:NP_001288341.1|ensembl:ENSMUSG00000028312(gene)|ensembl:ENSMUST00000102915(transcript)|ensembl:ENSMUST00000117280(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027120|interpro:IPR027417|interpro:IPR036277|mint:Q8CG48|rcsb pdb:3L51|reactome:R-MMU-2299718|reactome:R-MMU-2514853	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:14330(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:A8IwiTQIuTw7BA9PQ5ZTSmxFIQA10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:0AC8CBEBA94DD72A|rigid:QCygLMCh/xAiHLcCmBB0gpuF9fY	false	sufficient binding region:814-980	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CHG3	uniprotkb:Q8BH43	intact:EBI-643470|uniprotkb:Q8BR44|uniprotkb:Q8R2Q5|uniprotkb:Q9CT45	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:gcc2_mouse(display_long)|uniprotkb:185 kDa Golgi coiled-coil protein(gene name synonym)|uniprotkb:Gcc2(gene name)|psi-mi:Gcc2(display_short)|uniprotkb:Kiaa0336(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651103	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000237(GRIP)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0016020"(membrane)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0070861"(regulation of protein exit from endoplasmic reticulum)|go:"GO:0071955"(recycling endosome to Golgi transport)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR032023|reactome:R-MMU-6811440	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34956(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jx7CHCvebJMJveYd27Mhq56/So010090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:280263A9569C6A37|rigid:Qh/wG84iqOi1poPkuEG4VvUxAcI	false	sufficient binding region:392-618	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CHG3	uniprotkb:Q8BH43	intact:EBI-643470|uniprotkb:Q8BR44|uniprotkb:Q8R2Q5|uniprotkb:Q9CT45	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:gcc2_mouse(display_long)|uniprotkb:185 kDa Golgi coiled-coil protein(gene name synonym)|uniprotkb:Gcc2(gene name)|psi-mi:Gcc2(display_short)|uniprotkb:Kiaa0336(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651133	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000237(GRIP)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0016020"(membrane)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0070861"(regulation of protein exit from endoplasmic reticulum)|go:"GO:0071955"(recycling endosome to Golgi transport)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR032023|reactome:R-MMU-6811440	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34956(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jx7CHCvebJMJveYd27Mhq56/So010090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:E4E8C3C22D1169F9|rigid:Qh/wG84iqOi1poPkuEG4VvUxAcI	false	sufficient binding region:457-769	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91VR8	uniprotkb:Q8BH43	intact:EBI-643491|uniprotkb:Q3TLB8|ensembl:ENSMUSP00000041644	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:brk1_mouse(display_long)|uniprotkb:Brk1(gene name)|psi-mi:Brk1(display_short)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651173	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000033940(gene)|ensembl:ENSMUST00000035725(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048870"(cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR033378|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_598698.1	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34964(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:i3lwUUzuMjLnJpAMYYhOg4YmpVc10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:4CC069CB08EBCE23|rigid:8nQY9ko8y5YI6cfmSnlnppNhwHc	false	sufficient binding region:4-75	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DBG5	uniprotkb:Q8BH43	intact:EBI-643495|uniprotkb:Q3TK05|uniprotkb:Q8BKV9|uniprotkb:Q9CZK1|ensembl:ENSMUSP00000019726	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:plin3_mouse(display_long)|uniprotkb:Cargo selection protein TIP47(gene name synonym)|uniprotkb:Plin3(gene name)|psi-mi:Plin3(display_short)|uniprotkb:Tip47(gene name synonym)|uniprotkb:M6prbp1(gene name synonym)|uniprotkb:Mannose-6-phosphate receptor-binding protein 1(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651182	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000024197(gene)|ensembl:ENSMUST00000019726(transcript)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0010008"(endosome membrane)|go:"GO:0010890"(positive regulation of sequestering of triglyceride)|go:"GO:0019915"(lipid storage)|interpro:IPR004279(Perilipin)|mint:Q9DBG5|rcsb pdb:1SZI|reactome:R-MMU-6811440|reactome:R-MMU-9706019|refseq:NP_080112.1|dip:DIP-49514N	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:30205(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:gCL47LSurG1CNSS2YZcYpaBV5vQ10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:F2BF54258480B2DF|rigid:V4OYWUL5vhBk7YQxgWoTxMSxktk	false	sufficient binding region:1-190	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70494	uniprotkb:E9PZQ0	intact:EBI-643514|uniprotkb:Q68FF2|uniprotkb:Q8CF64|uniprotkb:Q8K378|uniprotkb:A2AQK9|ensembl:ENSMUSP00000099750	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:sp3_mouse(display_long)|uniprotkb:Sp3(gene name)|psi-mi:Sp3(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651212	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001018052.1|refseq:NP_001091895.1|ensembl:ENSMUSG00000027109(gene)|ensembl:ENSMUST00000102689(transcript)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001779"(natural killer cell differentiation)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001889"(liver development)|go:"GO:0001892"(embryonic placenta development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0016605"(PML body)|go:"GO:0017053"(transcription repressor complex)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030219"(megakaryocyte differentiation)|go:"GO:0030224"(monocyte differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0043353"(enucleate erythrocyte differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0048596"(embryonic camera-type eye morphogenesis)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:0060136"(embryonic process involved in female pregnancy)|go:"GO:0060216"(definitive hemopoiesis)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030452|interpro:IPR036236|reactome:R-MMU-3232118|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34670(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:izeFtcV7YpLdKJa2hU8CA/8UqLc10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:56AED2B4EEF23F6A|rigid:RaN3PUIRBEq3Rjo5Up0QHNGFVYc	false	sufficient binding region:132-642	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O89100	uniprotkb:Q9QUN3	intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681	intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844	psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym)	psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N	refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)	afcs:21969(primary-reference)|afcs:7609(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090	rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090	intact-crc:2EAF89BF0EABE76F|rigid:2rJtSPvBgytIVQCq7OltBUzO5m8	false	sufficient binding region:31-322	sufficient binding region:150-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O89100	uniprotkb:Q9QUN3	intact:EBI-642151|ensembl:ENSMUSP00000046532|ensembl:ENSMUSP00000155681	intact:EBI-642145|uniprotkb:O88504|ensembl:ENSMUSP00000057844	psi-mi:grap2_mouse(display_long)|uniprotkb:GADS protein(gene name synonym)|uniprotkb:Growth factor receptor-binding protein(gene name synonym)|uniprotkb:GRBLG(gene name synonym)|uniprotkb:GRB-2-like protein(gene name synonym)|uniprotkb:Hematopoietic cell-associated adaptor protein GrpL(gene name synonym)|uniprotkb:GRB-2-related monocytic adapter protein(gene name synonym)|uniprotkb:Adapter protein GRID(gene name synonym)|uniprotkb:Grap2(gene name)|psi-mi:Grap2(display_short)|uniprotkb:Gads(gene name synonym)|uniprotkb:Grb2l(gene name synonym)|uniprotkb:Grid(gene name synonym)|uniprotkb:Mona(gene name synonym)	psi-mi:blnk_mouse(display_long)|uniprotkb:Cytoplasmic adapter protein(gene name synonym)|uniprotkb:B-cell adapter containing a SH2 domain protein(gene name synonym)|uniprotkb:B-cell adapter containing a Src homology 2 domain protein(gene name synonym)|uniprotkb:Src homology 2 domain-containing leukocyte protein of 65 kDa(gene name synonym)|uniprotkb:Lymphocyte antigen 57(gene name synonym)|uniprotkb:Blnk(gene name)|psi-mi:Blnk(display_short)|uniprotkb:Bash(gene name synonym)|uniprotkb:Ly57(gene name synonym)|uniprotkb:Slp65(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649308	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001276371.1|refseq:NP_034945.1|ensembl:ENSMUSG00000042351(gene)|ensembl:ENSMUST00000043149(transcript)|ensembl:ENSMUST00000229980(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035646|interpro:IPR036028|interpro:IPR036860|interpro:IPR043539|mint:O89100|rcsb pdb:1H3H|rcsb pdb:1OEB|rcsb pdb:1R1P|rcsb pdb:1R1Q|rcsb pdb:1R1S|rcsb pdb:1UTI|rcsb pdb:2D0N|rcsb pdb:2W10|reactome:R-MMU-1433557|reactome:R-MMU-202433|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-389356|reactome:R-MMU-9607240|dip:DIP-41343N	refseq:NP_032554.2|ensembl:ENSMUSG00000061132(gene)|ensembl:ENSMUST00000054769(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042113"(B cell activation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000980(SH2 motif)|interpro:IPR036860|rcsb pdb:2EO6|reactome:R-MMU-983695|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)	afcs:21969(primary-reference)|afcs:7609(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mHMapg+wLVtfZ6IQ2rAGoVeyEHQ10090	rogid:usS1n4qdW7RcYvhLK2O11z9O4uw10090	intact-crc:0192FD61A26CC513|rigid:2rJtSPvBgytIVQCq7OltBUzO5m8	false	sufficient binding region:187-322	sufficient binding region:150-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:Q8BWG8	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649729	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:2DC214ED9C3A88FF|rigid:jbF69OubAfrWvihbeLD0WRdjIUw	false	sufficient binding region:123-280	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:Q8BWG8	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649739	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:4A6173C1DFB30113|rigid:jbF69OubAfrWvihbeLD0WRdjIUw	false	sufficient binding region:129-280	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35387	uniprotkb:Q8BWG8	intact:EBI-642449|uniprotkb:Q542F8|ensembl:ENSMUSP00000078661	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:hax1_mouse(display_long)|uniprotkb:HS1-associating protein X-1(gene name synonym)|uniprotkb:HS1-binding protein 1(gene name synonym)|uniprotkb:Hax1(gene name)|psi-mi:Hax1(display_short)|uniprotkb:Hs1bp1(gene name synonym)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649749	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035956.1|ensembl:ENSMUSG00000027944(gene)|ensembl:ENSMUST00000079724(transcript)|go:"GO:0000932"(P-body)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005938"(cell cortex)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019966"(interleukin-1 binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030136"(clathrin-coated vesicle)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0030854"(positive regulation of granulocyte differentiation)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:2000251"(positive regulation of actin cytoskeleton reorganization)|interpro:IPR017248(HS1-associating, X-1)|mint:O35387|dip:DIP-49445N	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:7438(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Jsw3mjyZheyvkAXjJXFOWduNC4s10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:D5E4D90782F49E2B|rigid:jbF69OubAfrWvihbeLD0WRdjIUw	false	sufficient binding region:157-280	sufficient binding region:320-418	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JLQ2	uniprotkb:Q9ES28	intact:EBI-642860|uniprotkb:E9QPU7|ensembl:ENSMUSP00000107803	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:git2_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 2(gene name synonym)|uniprotkb:GRK-interacting protein 2(gene name synonym)|uniprotkb:Cool-interacting tyrosine-phosphorylated protein 2(gene name synonym)|uniprotkb:Git2(gene name)|psi-mi:Git2(display_short)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650276	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062808.3|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q9JLQ2|rcsb pdb:6JMT|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|ensembl:ENSMUSG00000041890(gene)|ensembl:ENSMUST00000112185(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	afcs:17882(primary-reference)|afcs:18337(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mOkKto/u8bzW0feEp3Kah7fYeOI10090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	intact-crc:AE2B757E4B16B8B6|rigid:Gf/L0bks/IehTveMU+ldy5LxVDw	false	sufficient binding region:1-364	sufficient binding region:300-581	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ES28	uniprotkb:Q9JLQ2	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	intact:EBI-642860|uniprotkb:E9QPU7|ensembl:ENSMUSP00000107803	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:git2_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 2(gene name synonym)|uniprotkb:GRK-interacting protein 2(gene name synonym)|uniprotkb:Cool-interacting tyrosine-phosphorylated protein 2(gene name synonym)|uniprotkb:Git2(gene name)|psi-mi:Git2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650297	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	refseq:NP_062808.3|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q9JLQ2|rcsb pdb:6JMT|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|ensembl:ENSMUSG00000041890(gene)|ensembl:ENSMUST00000112185(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)	afcs:17882(primary-reference)|afcs:18337(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	rogid:mOkKto/u8bzW0feEp3Kah7fYeOI10090	intact-crc:2E63430D4235C471|rigid:Gf/L0bks/IehTveMU+ldy5LxVDw	false	sufficient binding region:300-581	sufficient binding region:1-410	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JLQ2	uniprotkb:Q9ES28	intact:EBI-642860|uniprotkb:E9QPU7|ensembl:ENSMUSP00000107803	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:git2_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 2(gene name synonym)|uniprotkb:GRK-interacting protein 2(gene name synonym)|uniprotkb:Cool-interacting tyrosine-phosphorylated protein 2(gene name synonym)|uniprotkb:Git2(gene name)|psi-mi:Git2(display_short)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650317	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062808.3|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q9JLQ2|rcsb pdb:6JMT|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|ensembl:ENSMUSG00000041890(gene)|ensembl:ENSMUST00000112185(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	afcs:17882(primary-reference)|afcs:18337(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mOkKto/u8bzW0feEp3Kah7fYeOI10090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	intact-crc:466188D3C502F45A|rigid:Gf/L0bks/IehTveMU+ldy5LxVDw	false	sufficient binding region:168-486	sufficient binding region:300-581	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JLQ2	uniprotkb:Q9ES28	intact:EBI-642860|uniprotkb:E9QPU7|ensembl:ENSMUSP00000107803	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:git2_mouse(display_long)|uniprotkb:G protein-coupled receptor kinase-interactor 2(gene name synonym)|uniprotkb:GRK-interacting protein 2(gene name synonym)|uniprotkb:Cool-interacting tyrosine-phosphorylated protein 2(gene name synonym)|uniprotkb:Git2(gene name)|psi-mi:Git2(display_short)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650327	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062808.3|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR001164(Arf GTPase activating protein)|interpro:IPR002110(Ankyrin)|interpro:IPR013724("Spa2 homology (SHD) of GIT")|interpro:IPR020683|interpro:IPR022018|interpro:IPR036770|interpro:IPR037278|interpro:IPR038508|mint:Q9JLQ2|rcsb pdb:6JMT|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|ensembl:ENSMUSG00000041890(gene)|ensembl:ENSMUST00000112185(transcript)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0044305"(calyx of Held)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0099171"(presynaptic modulation of chemical synaptic transmission)	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	afcs:17882(primary-reference)|afcs:18337(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mOkKto/u8bzW0feEp3Kah7fYeOI10090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	intact-crc:E88981D3707FDBAA|rigid:Gf/L0bks/IehTveMU+ldy5LxVDw	false	sufficient binding region:260-513	sufficient binding region:300-581	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61457	uniprotkb:Q99N72	intact:EBI-643090|uniprotkb:Q05BA1|uniprotkb:Q05BA6|uniprotkb:Q05BB7|ensembl:ENSMUSP00000103658	intact:EBI-641874	psi-mi:ccne1_mouse(display_long)|uniprotkb:Ccne1(gene name)|psi-mi:Ccne1(display_short)|uniprotkb:Ccne(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031659.2|ensembl:ENSMUSG00000002068(gene)|ensembl:ENSMUST00000108023(transcript)|go:"GO:0000079"(regulation of cyclin-dependent protein serine/threonine kinase activity)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000307"(cyclin-dependent protein kinase holoenzyme complex)|go:"GO:0000723"(telomere maintenance)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0006270"(DNA replication initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007129"(homologous chromosome pairing at meiosis)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0016301"(kinase activity)|go:"GO:0016538"(cyclin-dependent protein serine/threonine kinase regulator activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0044772"(mitotic cell cycle phase transition)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0051301"(cell division)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0070192"(chromosome organization involved in meiotic cell cycle)|go:"GO:0097134"(cyclin E1-CDK2 complex)|go:"GO:1902462"(positive regulation of mesenchymal stem cell proliferation)|go:"GO:1903827"|interpro:IPR004367(Cyclin, C-terminal)|interpro:IPR006671(Cyclin, N-terminal)|interpro:IPR013763(Cyclin-related)|interpro:IPR028858|interpro:IPR036915|interpro:IPR039361|mint:Q61457|reactome:R-MMU-1538133|reactome:R-MMU-187577|reactome:R-MMU-2559586|reactome:R-MMU-6804116|reactome:R-MMU-69017|reactome:R-MMU-69200|reactome:R-MMU-69202|reactome:R-MMU-69231|reactome:R-MMU-69563|reactome:R-MMU-8849470|reactome:R-MMU-9706019|dip:DIP-45868N	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:13998(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:xSi4shI5OjbHkude4aCAmrzr/u410090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:525CA1847400EF84|rigid:nGYfj74SZ/z0bGrh1bhScCM5THM	false	sufficient binding region:1-128	sufficient binding region:218-328	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08529	uniprotkb:Q60591	intact:EBI-643151|uniprotkb:O35518|uniprotkb:O54843|ensembl:ENSMUSP00000068895	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:can2_mouse(display_long)|uniprotkb:Calpain-2 large subunit(gene name synonym)|uniprotkb:Calcium-activated neutral proteinase 2(gene name synonym)|uniprotkb:Calpain M-type(gene name synonym)|uniprotkb:Millimolar-calpain(gene name synonym)|uniprotkb:80 kDa M-calpain subunit(gene name synonym)|uniprotkb:Capn2(gene name)|psi-mi:Capn2(display_short)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650642	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033924.2|interpro:IPR002048(Calcium-binding EF-hand)|ensembl:ENSMUSG00000026509(gene)|ensembl:ENSMUST00000068505(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006508"(proteolysis)|go:"GO:0007520"(myoblast fusion)|go:"GO:0007565"(female pregnancy)|go:"GO:0000785"(chromatin)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008233"(peptidase activity)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010666"(positive regulation of cardiac muscle cell apoptotic process)|go:"GO:0016020"(membrane)|go:"GO:0016540"(protein autoprocessing)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001824"(blastocyst development)|go:"GO:0019899"(enzyme binding)|go:"GO:0030425"(dendrite)|go:"GO:0031143"(pseudopodium)|go:"GO:0032675"(regulation of interleukin-6 production)|go:"GO:0035458"(cellular response to interferon-beta)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0004198"(calcium-dependent cysteine-type endopeptidase activity)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048266"(behavioral response to pain)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051603"(proteolysis involved in cellular protein catabolic process)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0005509"(calcium ion binding)|go:"GO:0071230"(cellular response to amino acid stimulus)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2001247"(positive regulation of phosphatidylcholine biosynthetic process)|interpro:IPR000169(Peptidase, cysteine peptidase active site)|interpro:IPR001300(Peptidase C2, calpain)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005764"(lysosome)|go:"GO:0005783"(endoplasmic reticulum)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR022682|interpro:IPR022683|interpro:IPR022684|interpro:IPR029539|interpro:IPR033883|interpro:IPR036213|interpro:IPR038765|interpro:IPR042736|mint:O08529|reactome:R-MMU-1474228	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	afcs:53032(primary-reference)|afcs:15757(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1AC+IJ8bHwaYB7bBlMFxmV8PNss10090	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	intact-crc:D48A117693734682|rigid:IQh1fkf8pgGV/NxKx3a9FD5HUnQ	false	sufficient binding region:519-700	sufficient binding region:200-420	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CX30	uniprotkb:Q8BH43	intact:EBI-643179|ensembl:ENSMUSP00000032809|uniprotkb:Q32M25|uniprotkb:Q3UXJ5	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:yif1b_mouse(display_long)|uniprotkb:YIP1-interacting factor homolog B(gene name synonym)|uniprotkb:Yif1b(gene name)|psi-mi:Yif1b(display_short)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650672	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103671.1|refseq:NP_084163.2|ensembl:ENSMUSG00000030588(gene)|ensembl:ENSMUST00000032809(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0030134"(COPII-coated ER to Golgi transport vesicle)|go:"GO:0030173"(integral component of Golgi membrane)|go:"GO:0033116"(endoplasmic reticulum-Golgi intermediate compartment membrane)|interpro:IPR005578(Hrf1)	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:3600(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:wUT7xFZMlSydfxqnCChePMSJeLU10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:EAD01F9A71ABBF78|rigid:cQmhueBj9s2LMcGtQumlKUyIZ98	false	sufficient binding region:33-311	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91WZ8-1	uniprotkb:Q8BH43	intact:EBI-643199|ensembl:ENSMUSP00000072170	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:q91wz8-1(display_long)|uniprotkb:Dtnbp1(gene name)|psi-mi:Dtnbp1(display_short)|uniprotkb:Sdy(gene name synonym)|uniprotkb:Dysbindin-1(gene name synonym)|uniprotkb:Dystrobrevin-binding protein 1(gene name synonym)|uniprotkb:Hermansky-Pudlak syndrome 7 protein homolog(gene name synonym)|uniprotkb:Biogenesis of lysosome-related organelles complex 1 subunit 8(gene name synonym)|uniprotkb:Bloc1s8(gene name synonym)|uniprotkb:Dysbindin 1-A(isoform synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650683	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-643186(dtbp1_mouse)|ensembl:ENSMUSG00000057531(gene)|ensembl:ENSMUST00000072329(transcript)	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:30807(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Ti6ll21EIIXrlkURsG7Uj0XUg6010090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:2DD33F124CE1055B|rigid:V1fAvEqDeA+YZ390ETJco9XyzL8	false	sufficient binding region:1-350	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C3I8	uniprotkb:P09055	intact:EBI-644392|uniprotkb:Q9JJF4|ensembl:ENSMUSP00000023213	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:hgh1_mouse(display_long)|uniprotkb:Hgh1(gene name)|psi-mi:Hgh1(display_short)|uniprotkb:Brp16(gene name synonym)|uniprotkb:Fam203a(gene name synonym)|uniprotkb:MNCb-5873(orf name)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652249	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_067530.2|ensembl:ENSMUSG00000022554(gene)|ensembl:ENSMUST00000023213(transcript)|interpro:IPR007205(Protein of unknown function DUF383)|interpro:IPR007206(Protein of unknown function DUF384)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039717	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:18892(primary-reference)|afcs:24036(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/cIz6zUzGXE6w9k0tllMzCrxkWU10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:C49E23F375D2CCC2|rigid:VeOBisvO1p+zs24gfftKyLUMA7I	false	sufficient binding region:288-393	sufficient binding region:750-798	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C3J5	uniprotkb:Q99N72	intact:EBI-644125|uniprotkb:Q5SRI4|uniprotkb:Q99M79|ensembl:ENSMUSP00000090884	intact:EBI-641874	psi-mi:dock2_mouse(display_long)|uniprotkb:Protein Hch(gene name synonym)|uniprotkb:Dock2(gene name)|psi-mi:Dock2(display_short)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652259	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_203538.2|go:"GO:0001771"(immunological synapse formation)|go:"GO:0002277"(myeloid dendritic cell activation involved in immune response)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005856"(cytoskeleton)|go:"GO:0006935"(chemotaxis)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0035022"(positive regulation of Rac protein signal transduction)|go:"GO:0042098"(T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0044351"(macropinocytosis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045060"(negative thymic T cell selection)|go:"GO:0046631"(alpha-beta T cell activation)|go:"GO:0046633"(alpha-beta T cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|interpro:IPR001452(Src homology-3)|interpro:IPR010703(Dedicator of cytokinesis)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR026799|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|go:"GO:0001768"(establishment of T cell polarity)|ensembl:ENSMUSG00000020143(gene)|ensembl:ENSMUST00000093193(transcript)|go:"GO:0001766"(membrane raft polarization)|interpro:IPR043161|interpro:IPR043162|reactome:R-MMU-6798695|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-983231|interpro:IPR042455	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:30822(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0PrDsFHFXIL3v/zw0WssoOB8qbA10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:EDF46468F5F0082A|rigid:jzKN5uWF0ktqkqI6P/MvtBbnm/s	false	sufficient binding region:851-948	sufficient binding region:5-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1E3	uniprotkb:Q04207	intact:EBI-644427|uniprotkb:Q80ZX5|ensembl:ENSMUSP00000021413|uniprotkb:Q3U9W9|uniprotkb:Q3UB40	intact:EBI-644400|uniprotkb:Q62025|ensembl:ENSMUSP00000025867	psi-mi:ikba_mouse(display_long)|uniprotkb:I-kappa-B-alpha(gene name synonym)|uniprotkb:Nfkbia(gene name)|psi-mi:Nfkbia(display_short)|uniprotkb:Ikba(gene name synonym)	psi-mi:tf65_mouse(display_long)|uniprotkb:Nuclear factor NF-kappa-B p65 subunit(gene name synonym)|uniprotkb:Rela(gene name)|psi-mi:Rela(display_short)|uniprotkb:Nfkb3(gene name synonym)|uniprotkb:Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652269	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035037.2|ensembl:ENSMUSG00000021025(gene)|ensembl:ENSMUST00000021413(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007253"(cytoplasmic sequestering of NF-kappaB)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010745"(negative regulation of macrophage derived foam cell differentiation)|go:"GO:0010875"(positive regulation of cholesterol efflux)|go:"GO:0010888"(negative regulation of lipid storage)|go:"GO:0019899"(enzyme binding)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032270"(positive regulation of cellular protein metabolic process)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042994"(cytoplasmic sequestering of transcription factor)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045638"(negative regulation of myeloid cell differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0070427"(nucleotide-binding oligomerization domain containing 1 signaling pathway)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071407"(cellular response to organic cyclic compound)|interpro:IPR002110(Ankyrin)|interpro:IPR020683|interpro:IPR036770|mint:Q9Z1E3|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-9020702|reactome:R-MMU-933542|dip:DIP-36160N	refseq:NP_033071.1|reactome:R-MMU-2871837|reactome:R-MMU-3134963|reactome:R-MMU-3214841|reactome:R-MMU-445989|reactome:R-MMU-448706|reactome:R-MMU-4755510|reactome:R-MMU-5607764|reactome:R-MMU-5621575|reactome:R-MMU-9020702|reactome:R-MMU-933542|rcsb pdb:2RAM|rcsb pdb:5U01|rcsb pdb:6GGR|reactome:R-MMU-1169091|reactome:R-MMU-1810476|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-209560|ensembl:ENSMUSG00000024927(gene)|ensembl:ENSMUST00000025867(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000979"(RNA polymerase II core promoter sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001223"(transcription coactivator binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001889"(liver development)|go:"GO:0001942"(hair follicle development)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006117"(acetaldehyde metabolic process)|go:"GO:0006325"(chromatin organization)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010033"(response to organic substance)|go:"GO:0010224"(response to UV-B)|go:"GO:0014040"(positive regulation of Schwann cell differentiation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032332"(positive regulation of chondrocyte differentiation)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032570"(response to progesterone)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0033590"(response to cobalamin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035525"(NF-kappaB p50/p65 complex)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038061"(NIK/NF-kappaB signaling)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042277"(peptide binding)|go:"GO:0042301"(phosphate ion binding)|go:"GO:0042493"|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042805"(actinin binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043200"(response to amino acid)|go:"GO:0043278"(response to morphine)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050862"(positive regulation of T cell receptor signaling pathway)|go:"GO:0051059"(NF-kappaB binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051591"(response to cAMP)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070431"(nucleotide-binding oligomerization domain containing 2 signaling pathway)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0043620"(regulation of DNA-templated transcription in response to stress)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045202"(synapse)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071159"(NF-kappaB complex)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071224"(cellular response to peptidoglycan)|go:"GO:0071316"(cellular response to nicotine)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071354"(cellular response to interleukin-6)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071532"(ankyrin repeat binding)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0140296"(general transcription initiation factor binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1901522"(positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus)|go:"GO:1902004"(positive regulation of amyloid-beta formation)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000630"(positive regulation of miRNA metabolic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR000451(NF-kappa-B/Rel/dorsal)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR030492|interpro:IPR030495|interpro:IPR032397|interpro:IPR033926|mint:Q04207|rcsb pdb:1BFT|rcsb pdb:1IKN|rcsb pdb:1K3Z|rcsb pdb:1LE5|rcsb pdb:1LE9|rcsb pdb:1LEI|rcsb pdb:1MY5|rcsb pdb:1MY7|rcsb pdb:1OY3|rcsb pdb:1RAM|interpro:IPR037059|rcsb pdb:1VKX|rcsb pdb:2I9T|rcsb pdb:2LWW|dip:DIP-6219N	afcs:12430(primary-reference)|afcs:16466(secondary-ac)	-	-	caution:The prey construct contains 19 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:9uG+85E5n7tKNUUDcVTK2fH2UOM10090	rogid:poiJSPJwXK2Om5pfk8z5HwFgK1o10090	intact-crc:303231B0541B4B77|rigid:TnapRWmsu5aA4euGsip1JMZa5mk	false	sufficient binding region:1-314	sufficient binding region:200-430	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BKC5	uniprotkb:Q61210	intact:EBI-643605|uniprotkb:Q3TEG2|uniprotkb:Q7TQC6|uniprotkb:Q9EQ30|ensembl:ENSMUSP00000032898	intact:EBI-641821|uniprotkb:O89074|uniprotkb:Q3T9Q7|uniprotkb:Q80YE8|uniprotkb:Q80YE9|uniprotkb:Q91VL3|ensembl:ENSMUSP00000046469|ensembl:ENSMUSP00000113366	psi-mi:ipo5_mouse(display_long)|uniprotkb:Ranbp5(gene name synonym)|uniprotkb:Importin subunit beta-3(gene name synonym)|uniprotkb:Karyopherin beta-3(gene name synonym)|uniprotkb:Ran-binding protein 5(gene name synonym)|uniprotkb:Ipo5(gene name)|psi-mi:Ipo5(display_short)|uniprotkb:Kpnb3(gene name synonym)	psi-mi:arhg1_mouse(display_long)|uniprotkb:Lymphoid blast crisis-like 2(gene name synonym)|uniprotkb:Lbc's second cousin(gene name synonym)|uniprotkb:Arhgef1(gene name)|psi-mi:Arhgef1(display_short)|uniprotkb:Lbcl2(gene name synonym)|uniprotkb:Lsc(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651319	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076068.1|refseq:XP_006519603.1|ensembl:ENSMUSG00000030662(gene)|ensembl:ENSMUST00000032898(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006610"(ribosomal protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0061608"(nuclear import signal receptor activity)|go:"GO:0071230"(cellular response to amino acid stimulus)|interpro:IPR000357(HEAT)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR034085|interpro:IPR040122|interpro:IPR040928|interpro:IPR041389|interpro:IPR041653|mint:Q8BKC5|go:"GO:0006607"(NLS-bearing protein import into nucleus)	refseq:NP_001123622.1|refseq:NP_001123623.1|refseq:NP_001123624.1|refseq:NP_001123625.1|refseq:NP_032514.1|ensembl:ENSMUSG00000040940(gene)|ensembl:ENSMUST00000047873(transcript)|ensembl:ENSMUST00000117419(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR015212(Regulator of G protein signalling-like fold)|interpro:IPR035899|interpro:IPR036305|interpro:IPR037887|interpro:IPR041020|mint:Q61210|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106|interpro:IPR001849(Pleckstrin-like)	afcs:14722(primary-reference)|afcs:20927(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZtMfEhsr1lfJDBglaNlc7j4GHZ010090	rogid:4XIOfncTZyk1NOpLrFskWzCFAPE10090	intact-crc:EFEA14831FE45E16|rigid:S70J/O3NlOlRPXKFt0nCTk/LLdQ	false	sufficient binding region:363-695	sufficient binding region:200-502	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01853	uniprotkb:E9Q401	intact:EBI-80597|ensembl:ENSMUSP00000030164|uniprotkb:Q3TFH9|uniprotkb:Q3TIM2|uniprotkb:Q3TXN9|uniprotkb:Q6PI18|uniprotkb:Q8BSR6|uniprotkb:Q8CEG4	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	psi-mi:tera_mouse(display_long)|uniprotkb:Vcp(gene name)|psi-mi:Vcp(display_short)|uniprotkb:"15S Mg(2+)-ATPase p97 subunit"(gene name synonym)|uniprotkb:Valosin-containing protein(gene name synonym)	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651351	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045732"(positive regulation of protein catabolic process)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0046034"(ATP metabolic process)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050807"(regulation of synapse organization)|go:"GO:0051228"(mitotic spindle disassembly)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070842"(aggresome assembly)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0072389"(flavin adenine dinucleotide catabolic process)|go:"GO:0090263"(positive regulation of canonical Wnt signaling pathway)|go:"GO:0036513"(Derlin-1 retrotranslocation complex)|go:"GO:0097352"(autophagosome maturation)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0042288"(MHC class I protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043531"(ADP binding)|go:"GO:0044389"(ubiquitin-like protein ligase binding)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1903006"(positive regulation of protein K63-linked deubiquitination)|go:"GO:1903007"(positive regulation of Lys63-specific deubiquitinase activity)|go:"GO:1903715"(regulation of aerobic respiration)|go:"GO:1903843"(cellular response to arsenite ion)|go:"GO:1903862"(positive regulation of oxidative phosphorylation)|go:"GO:1904288"(BAT3 complex binding)|go:"GO:1904949"(ATPase complex)|go:"GO:1905634"(regulation of protein localization to chromatin)|go:"GO:1990381"(ubiquitin-specific protease binding)|go:"GO:1990730"(VCP-NSFL1C complex)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|interpro:IPR003338(AAA ATPase VAT, N-terminal)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR004201(Cell division protein 48, CDC48, domain 2)|interpro:IPR005938(AAA ATPase, CDC48)|interpro:IPR009010(Aspartate decarboxylase-like fold)|interpro:IPR015415(Vps4 oligomerisation, C-terminal)|interpro:IPR027417|interpro:IPR029067|interpro:IPR041569|mint:Q01853|rcsb pdb:1E32|rcsb pdb:1R7R|rcsb pdb:1S3S|rcsb pdb:2PJH|rcsb pdb:3CF0|rcsb pdb:3CF1|rcsb pdb:3CF2|rcsb pdb:3CF3|reactome:R-MMU-110320|reactome:R-MMU-3371511|reactome:R-MMU-382556|reactome:R-MMU-532668|reactome:R-MMU-5358346|reactome:R-MMU-5689877|reactome:R-MMU-5689896|reactome:R-MMU-6798695|reactome:R-MMU-8876725|reactome:R-MMU-9013407|ensembl:ENSMUSG00000028452(gene)|ensembl:ENSMUST00000030164(transcript)|go:"GO:0000502"(proteasome complex)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006302"(double-strand break repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006734"(NADH metabolic process)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008289"(lipid binding)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0010918"(positive regulation of mitochondrial membrane potential)|go:"GO:0016236"(macroautophagy)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016887"(ATP hydrolysis activity)|go:"GO:0019079"(viral genome replication)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019985"(translesion synthesis)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0032510"(endosome to lysosome transport via multivesicular body sorting pathway)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034098"(VCP-NPL4-UFD1 AAA ATPase complex)|go:"GO:0034605"(cellular response to heat)|go:"GO:0035617"(stress granule disassembly)|go:"GO:0035800"(deubiquitinase activator activity)|go:"GO:0035861"(site of double-strand break)|go:"GO:0036297"(interstrand cross-link repair)|go:"GO:0036435"(K48-linked polyubiquitin modification-dependent protein binding)|go:"GO:0036503"(ERAD pathway)|go:"GO:0019904"(protein domain specific binding)|refseq:NP_033529.3|dip:DIP-29796N	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	afcs:24653(primary-reference)|afcs:15549(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:HrjDhdsDcgaf8HEbqqMjUqxPaEs10090	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	intact-crc:88E5410895EED226|rigid:+mXGWWTluUkk/2bfjGzGNMVfwZs	false	sufficient binding region:507-806	sufficient binding region:625-901	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BH43	uniprotkb:Q3URD3-4	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	intact:EBI-3294998|intact:EBI-647394	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:q3urd3-4(display_long)|uniprotkb:Slmap(gene name)|psi-mi:Slmap(display_short)|uniprotkb:Kiaa1601(gene name synonym)|uniprotkb:Slap(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650693	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	intact:EBI-643207(isoform-parent)	afcs:22839(primary-reference)|afcs:34965(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	rogid:z1xfy2NNULIGTqg9HvzD9/EHRCQ10090	intact-crc:E9CD4E30A3C07166|rigid:4a6pwCubc5XFX1dpL15fLx0epeY	false	sufficient binding region:1-170	sufficient binding region:31-161	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O55108	uniprotkb:E9PZQ0	intact:EBI-643315	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:o55108_mouse(display_long)|uniprotkb:Bsg(gene name)|psi-mi:Bsg(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650783	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005537"(mannose binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34643(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:99x0BoyhEaFoUtTrud/7CV0STYg10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:973295C520586DAB|rigid:wXBdjOi7vfF1uLDsJgUTMAFO6Wg	false	sufficient binding region:64-253	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O55107	uniprotkb:E9PZQ0	intact:EBI-643324	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:o55107_mouse(display_long)|uniprotkb:Bsg(gene name)|psi-mi:Bsg(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650792	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003599(Immunoglobulin subtype)|go:"GO:0005537"(mannose binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34642(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:tuxM7lXLqJ8tgIyk90elDHBYHqQ10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:A605DA07CC8F7177|rigid:2hfs3aB+X1Z+n54xDA9cphtOZiw	false	sufficient binding region:1-263	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70318	uniprotkb:Q8CIH5	intact:EBI-643339|uniprotkb:G3X9B8|ensembl:ENSMUSP00000055122|ensembl:ENSMUSP00000090314	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:e41l2_mouse(display_long)|uniprotkb:Generally expressed protein 4.1(gene name synonym)|uniprotkb:Epb41l2(gene name)|psi-mi:Epb41l2(display_short)|uniprotkb:Epb4.1l2(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 2(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650812	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038539.2|refseq:NP_001186194.1|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0005654"(nucleoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030507"(spectrin binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0051301"(cell division)|go:"GO:0099738"(cell cortex region)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030546|interpro:IPR035963|mint:O70318|reactome:R-MMU-6794361|ensembl:ENSMUSG00000019978(gene)|ensembl:ENSMUST00000053748(transcript)|ensembl:ENSMUST00000092645(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:34668(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4hNttT3WQk43puSMmOdjpNS8oUo10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:ADE11590609892A2|rigid:Bks3zDjLRJuOnd2/YEcsqgX9qsA	false	sufficient binding region:808-987	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q02384	uniprotkb:Q8CIH5	intact:EBI-395573|ensembl:ENSMUSP00000138793	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:sos2_mouse(display_long)|uniprotkb:Sos2(gene name)|psi-mi:Sos2(display_short)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650822	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000034801(gene)|ensembl:ENSMUST00000183277(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|rcsb pdb:1GBR|reactome:R-MMU-416482|reactome:R-MMU-193648|refseq:XP_006515698.1|reactome:R-MMU-8983432|reactome:R-MMU-9013149	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:33836(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:s2OD+2IxmqGbJeKCshNho0MJczM10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:3CD4BCDEA0C75DFC|rigid:FTERSEhcJAFgYpOnQTcQ2DkiYtU	false	sufficient binding region:1072-1229	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ES97	uniprotkb:Q8BWG8	intact:EBI-643369|uniprotkb:Q3UF62|uniprotkb:Q544J1|uniprotkb:Q68FE4|uniprotkb:Q6IM69|uniprotkb:Q6R8K6|uniprotkb:Q6R8K7|uniprotkb:Q6T929|uniprotkb:Q8C6D5|uniprotkb:Q8CCU2|ensembl:ENSMUSP00000065810	intact:EBI-641778|uniprotkb:Q3UH95|uniprotkb:Q8BTJ5|ensembl:ENSMUSP00000095866	psi-mi:rtn3_mouse(display_long)|uniprotkb:Rtn3(gene name)|psi-mi:Rtn3(display_short)	psi-mi:arrb1_mouse(display_long)|uniprotkb:Arrestin beta-1(gene name synonym)|uniprotkb:Arrb1(gene name)|psi-mi:Arrb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650862	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001003933.1|refseq:NP_001003934.1|refseq:NP_444306.1|refseq:NP_001258415.1|refseq:NP_001258416.1|ensembl:ENSMUSG00000024758(gene)|ensembl:ENSMUST00000065304(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006915"(apoptotic process)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0045202"(synapse)|go:"GO:0071786"(endoplasmic reticulum tubular network organization)|go:"GO:0071787"(endoplasmic reticulum tubular network formation)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|interpro:IPR003388(Reticulon)|mint:Q9ES97|reactome:R-MMU-8849932	refseq:NP_796205.1|refseq:NP_835738.1|dip:DIP-49444N|ensembl:ENSMUSG00000018909(gene)|ensembl:ENSMUST00000098266(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0000785"(chromatin)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002031"(G protein-coupled receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006897"(endocytosis)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007602"(phototransduction)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015031"(protein transport)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016604"(nuclear body)|go:"GO:0019899"(enzyme binding)|go:"GO:0030276"(clathrin binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0031143"(pseudopodium)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031434"(mitogen-activated protein kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031691"(alpha-1A adrenergic receptor binding)|go:"GO:0031692"(alpha-1B adrenergic receptor binding)|go:"GO:0031701"(angiotensin receptor binding)|go:"GO:0031762"(follicle-stimulating hormone receptor binding)|go:"GO:0031896"(V2 vasopressin receptor binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0034260"(negative regulation of GTPase activity)|go:"GO:0005905"(clathrin-coated pit)|go:"GO:0034393"(positive regulation of smooth muscle cell apoptotic process)|go:"GO:0035025"(positive regulation of Rho protein signal transduction)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035612"(AP-2 adaptor complex binding)|go:"GO:0035615"(clathrin adaptor activity)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0042699"(follicle-stimulating hormone signaling pathway)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043280"(positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045309"(protein phosphorylated amino acid binding)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0090240"(positive regulation of histone H4 acetylation)|go:"GO:1990763"(arrestin family protein binding)|interpro:IPR000698(Arrestin)|interpro:IPR011021(Arrestin-like, N-terminal)|interpro:IPR011022(Arrestin-like, C-terminal)|interpro:IPR014752(Arrestin, C-terminal)|interpro:IPR014753(Arrestin, N-terminal)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017864|mint:Q8BWG8|reactome:R-MMU-432720|reactome:R-MMU-432722|reactome:R-MMU-456926|reactome:R-MMU-5635838|reactome:R-MMU-5674135|reactome:R-MMU-5689880|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-418555	afcs:21847(primary-reference)|afcs:33842(secondary-ac)	-	-	caution:The prey construct contains 40 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:6FGasKiLqE0qkcxmPiyTcBrk2ek10090	rogid:QnjSypgRI1Aym+xBu3vpHxVSAD010090	intact-crc:D3A4572D49E47185|rigid:Z2n6/eRugxix2+P7z0L2mafs1Ks	false	sufficient binding region:1-237	sufficient binding region:1-211	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99JZ7	uniprotkb:Q8CIH5	intact:EBI-643375|ensembl:ENSMUSP00000073285|ensembl:ENSMUSP00000030811	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:errfi_mouse(display_long)|uniprotkb:Mitogen-inducible gene 6 protein homolog(gene name synonym)|uniprotkb:Errfi1(gene name)|psi-mi:Errfi1(display_short)|uniprotkb:Mig6(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650871	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598514.1|refseq:XP_006539273.1|ensembl:ENSMUSG00000028967(gene)|ensembl:ENSMUST00000030811(transcript)|ensembl:ENSMUST00000073600(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007175"(negative regulation of epidermal growth factor-activated receptor activity)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031098"(stress-activated protein kinase signaling cascade)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031953"(negative regulation of protein autophosphorylation)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032966"(negative regulation of collagen biosynthetic process)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042059"(negative regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045616"(regulation of keratinocyte differentiation)|go:"GO:0048286"(lung alveolus development)|go:"GO:0050732"(negative regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0060426"(lung vasculature development)|go:"GO:0060428"(lung epithelium development)|go:"GO:0061469"(regulation of type B pancreatic cell proliferation)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0071474"(cellular hyperosmotic response)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:1903243"(negative regulation of cardiac muscle hypertrophy in response to stress)|interpro:IPR015116(GTPase binding)|interpro:IPR021619	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:34646(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:flZOynxPIeNiLKGeuDeo6JXWdgw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:9239AF18C13DDFB9|rigid:+P0w6T+BG2jLF+DCVwAoj3s8Ut8	false	sufficient binding region:217-415	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QXJ2	uniprotkb:Q61179	intact:EBI-646643|ensembl:ENSMUSP00000082855	intact:EBI-646653|ensembl:ENSMUSP00000120359	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:irf9_mouse(display_long)|uniprotkb:Isgf3g(gene name synonym)|uniprotkb:Transcriptional regulator ISGF3 subunit gamma(gene name synonym)|uniprotkb:IFN-alpha-responsive transcription factor subunit(gene name synonym)|uniprotkb:Interferon-stimulated gene factor 3 gamma(gene name synonym)|uniprotkb:ISGF3 p48 subunit(gene name synonym)|uniprotkb:Irf9(gene name)|psi-mi:Irf9(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656671	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	refseq:NP_001152889.1|refseq:NP_001152890.1|refseq:NP_032420.1|reactome:R-MMU-909733|rcsb pdb:5OEN|ensembl:ENSMUSG00000002325(gene)|ensembl:ENSMUST00000130697(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5OEM	afcs:18399(primary-reference)|afcs:14647(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	rogid:JHbDnrkiCtNJ9ktn4N0RE3lk21E10090	intact-crc:DBDF688575BB9918|rigid:GFChxDWvYbBnzQ5GgTqeUn2w0+o	false	sufficient binding region:1-300	sufficient binding region:320-339	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88544	uniprotkb:Q9QXJ2	intact:EBI-646659|ensembl:ENSMUSP00000048416	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:csn4_mouse(display_long)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym)|uniprotkb:Cops4(gene name)|psi-mi:Cops4(display_short)|uniprotkb:Csn4(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656691	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036131.1|ensembl:ENSMUSG00000035297(gene)|ensembl:ENSMUST00000045993(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:O88544|rcsb pdb:1UFM|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:17150(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:oD7xaeBArd5bKxdEAWM/r+5KMb010090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:18A0449D08E23794|rigid:5qsyKrwiKj5PKCK6c2f/41mgovI	false	sufficient binding region:118-394	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88544	uniprotkb:Q9QXJ2	intact:EBI-646659|ensembl:ENSMUSP00000048416	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:csn4_mouse(display_long)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym)|uniprotkb:Cops4(gene name)|psi-mi:Cops4(display_short)|uniprotkb:Csn4(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656721	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036131.1|ensembl:ENSMUSG00000035297(gene)|ensembl:ENSMUST00000045993(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:O88544|rcsb pdb:1UFM|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:17150(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:oD7xaeBArd5bKxdEAWM/r+5KMb010090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:272B711F410D5922|rigid:5qsyKrwiKj5PKCK6c2f/41mgovI	false	sufficient binding region:269-406	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656873	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:30F8F6424436B9A2|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:19-342	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656883	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:8D1DEE456ACE1354|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:21-223	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656893	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:195A4E0F0F0A711E|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:46-370	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C886	uniprotkb:P39428	intact:EBI-646708|uniprotkb:Q8R3H1|uniprotkb:A0A1W2P6Q7|uniprotkb:A0A1W2P7X5|ensembl:ENSMUSP00000151799	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:pkhn1_mouse(display_long)|uniprotkb:Plekhn1(gene name)|psi-mi:Plekhn1(display_short)|uniprotkb:Cardiolipin and phosphatidic acid-binding protein(gene name synonym)|uniprotkb:Clpabp(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656943	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000078485(gene)|ensembl:ENSMUST00000217885(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR042835	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58120(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2018/10/11	rogid:mIzWRQmmgEyEzjsKvhnwbO1Frgw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:E8BC7CF6806A3F18|rigid:tO4nwY0LpWX+MNgkDcCadhFlT10	false	sufficient binding region:?-?	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C886	uniprotkb:P39428	intact:EBI-646708|uniprotkb:Q8R3H1|uniprotkb:A0A1W2P6Q7|uniprotkb:A0A1W2P7X5|ensembl:ENSMUSP00000151799	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:pkhn1_mouse(display_long)|uniprotkb:Plekhn1(gene name)|psi-mi:Plekhn1(display_short)|uniprotkb:Cardiolipin and phosphatidic acid-binding protein(gene name synonym)|uniprotkb:Clpabp(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656963	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000078485(gene)|ensembl:ENSMUST00000217885(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR042835	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58120(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2018/10/11	rogid:mIzWRQmmgEyEzjsKvhnwbO1Frgw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:11217F74425E129C|rigid:tO4nwY0LpWX+MNgkDcCadhFlT10	false	sufficient binding region:?-?	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P50247	uniprotkb:P39428	intact:EBI-646982|uniprotkb:Q91WF1|ensembl:ENSMUSP00000061851|ensembl:ENSMUSP00000127198	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:sahh_mouse(display_long)|uniprotkb:S-adenosyl-L-homocysteine hydrolase(gene name synonym)|uniprotkb:Liver copper-binding protein(gene name synonym)|uniprotkb:CUBP(gene name synonym)|uniprotkb:Ahcy(gene name)|psi-mi:Ahcy(display_short)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657725	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057870.3|refseq:NP_001291457.1|ensembl:ENSMUSG00000027597(gene)|ensembl:ENSMUSG00000048087(gene)|ensembl:ENSMUST00000054607(transcript)|ensembl:ENSMUST00000059524(transcript)|go:"GO:0002439"(chronic inflammatory response to antigenic stimulus)|go:"GO:0004013"(adenosylhomocysteinase activity)|go:"GO:0005507"(copper ion binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006730"(one-carbon metabolic process)|go:"GO:0007584"(response to nutrient)|go:"GO:0019510"(S-adenosylhomocysteine catabolic process)|go:"GO:0030554"(adenyl nucleotide binding)|go:"GO:0033353"(S-adenosylmethionine cycle)|go:"GO:0042470"(melanosome)|go:"GO:0042745"(circadian sleep/wake cycle)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0051287"(NAD binding)|interpro:IPR000043(S-adenosyl-L-homocysteine hydrolase)|interpro:IPR015878(S-adenosyl-L-homocysteine hydrolase, NAD binding)|interpro:IPR020082|interpro:IPR036291|interpro:IPR042172|mint:P50247|rcsb pdb:5AXA|rcsb pdb:5AXB|rcsb pdb:5AXC|reactome:R-MMU-156581|reactome:R-MMU-1614635|rcsb pdb:5AXD	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:17645(secondary-ac)	-	-	caution:The prey construct contains 11 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3huaZIY/NrWyXH/kTaMriwT35A410090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:C91C8FD78EA2F55A|rigid:cQc0LJoKQ3XWrfh/yWULGYUEPB0	false	sufficient binding region:2-313	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P39428	uniprotkb:Q9DC33	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	intact:EBI-646990|uniprotkb:Q8BSK1|uniprotkb:Q8C3C1|uniprotkb:Q8CAA0|uniprotkb:Q9CYG2|uniprotkb:Q3LSF9|uniprotkb:Q6NV87|ensembl:ENSMUSP00000034879|ensembl:ENSMUSP00000149698	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:hm20a_mouse(display_long)|uniprotkb:HMG domain-containing protein HMGX1(gene name synonym)|uniprotkb:HMG box-containing protein 20A(gene name synonym)|uniprotkb:Inhibitor of BRAF35(gene name synonym)|uniprotkb:Hmg20a(gene name)|psi-mi:Hmg20a(display_short)|uniprotkb:Ibraf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657735	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	refseq:NP_080088.1|refseq:XP_006511431.1|ensembl:ENSMUSG00000032329(gene)|ensembl:ENSMUST00000034879(transcript)|ensembl:ENSMUST00000215269(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006325"(chromatin organization)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0045665"(negative regulation of neuron differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|mint:Q9DC33	afcs:55765(primary-reference)|afcs:30787(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	rogid:uPs2AMRugDm5M7mcJY7852zxQOo10090	intact-crc:EB6C4F079AD1C089|rigid:VenAq/JFPNL0H1+D0BRJs6V86tI	false	sufficient binding region:100-270	sufficient binding region:108-346	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O89032	uniprotkb:P47713	intact:EBI-647535|uniprotkb:E9QKJ2|uniprotkb:Q148Q8|ensembl:ENSMUSP00000080325	intact:EBI-397673|ensembl:ENSMUSP00000070868	psi-mi:spd2a_mouse(display_long)|uniprotkb:SH3 multiple domains protein 1(gene name synonym)|uniprotkb:Five SH3 domain-containing protein(gene name synonym)|uniprotkb:Sh3pxd2a(gene name)|psi-mi:Sh3pxd2a(display_short)|uniprotkb:Fish(gene name synonym)|uniprotkb:Tyrosine kinase substrate with five SH3 domains(gene name synonym)|uniprotkb:Sh3md1(gene name synonym)|uniprotkb:Tks5(gene name synonym)	psi-mi:pa24a_mouse(display_long)|uniprotkb:Pla2g4a(gene name)|psi-mi:Pla2g4a(display_short)|uniprotkb:Cpla2(gene name synonym)|uniprotkb:Pla2g4(gene name synonym)|uniprotkb:Phospholipase A2 group IVA(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658577	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032044.2|refseq:NP_001158189.1|ensembl:ENSMUSG00000053617(gene)|ensembl:ENSMUST00000081619(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0002020"(protease binding)|go:"GO:0002102"(podosome)|go:"GO:0005546"(phosphatidylinositol-4,5-bisphosphate binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0030054"(cell junction)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042995"(cell projection)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0072675"(osteoclast fusion)|interpro:IPR001452(Src homology-3)|interpro:IPR001683(Phox-like)|interpro:IPR034917|interpro:IPR035449|interpro:IPR035450|interpro:IPR035452|interpro:IPR035453|interpro:IPR035454|interpro:IPR036028|interpro:IPR036871|interpro:IPR037961|mint:O89032|reactome:R-MMU-8941237|reactome:R-MMU-9013148	refseq:NP_032895.1|ensembl:ENSMUSG00000056220(gene)|ensembl:ENSMUST00000070200(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001516"(prostaglandin biosynthetic process)|go:"GO:0001542"(ovulation from ovarian follicle)|go:"GO:0002827"(positive regulation of T-helper 1 type immune response)|go:"GO:0004622"(lysophospholipase activity)|go:"GO:0004623"(phospholipase A2 activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006071"(glycerol metabolic process)|go:"GO:0006640"(monoacylglycerol biosynthetic process)|go:"GO:0006663"(platelet activating factor biosynthetic process)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008374"(O-acyltransferase activity)|go:"GO:0010033"(response to organic substance)|go:"GO:0010314"(phosphatidylinositol-5-phosphate binding)|go:"GO:0010572"(positive regulation of platelet activation)|go:"GO:0019369"(arachidonic acid metabolic process)|go:"GO:0019370"(leukotriene biosynthetic process)|go:"GO:0031340"(positive regulation of vesicle fusion)|go:"GO:0031394"(positive regulation of prostaglandin biosynthetic process)|go:"GO:0032266"(phosphatidylinositol-3-phosphate binding)|go:"GO:0034478"(phosphatidylglycerol catabolic process)|go:"GO:0034638"(phosphatidylcholine catabolic process)|go:"GO:0035035"(histone acetyltransferase binding)|go:"GO:0036151"(phosphatidylcholine acyl-chain remodeling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042588"(zymogen granule)|go:"GO:0043032"(positive regulation of macrophage activation)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043129"(surfactant homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046456"(icosanoid biosynthetic process)|go:"GO:0046475"(glycerophospholipid catabolic process)|go:"GO:0046697"(decidualization)|go:"GO:0047498"(calcium-dependent phospholipase A2 activity)|go:"GO:0047499"(calcium-independent phospholipase A2 activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050482"(arachidonic acid secretion)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0051592"(response to calcium ion)|go:"GO:0070273"(phosphatidylinositol-4-phosphate binding)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0102545"(phosphatidyl phospholipase B activity)|go:"GO:0032308"(positive regulation of prostaglandin secretion)|go:"GO:0102567"|go:"GO:0102568"|go:"GO:1902387"(ceramide 1-phosphate binding)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR002642(Lysophospholipase, catalytic region)|interpro:IPR016035(Acyl transferase/acyl hydrolase/lysophospholipase)|interpro:IPR035892|interpro:IPR041847|mint:P47713|reactome:R-MMU-111995|reactome:R-MMU-1482788|reactome:R-MMU-1482798|reactome:R-MMU-1482801|reactome:R-MMU-1482839|reactome:R-MMU-1482922|reactome:R-MMU-1482925|reactome:R-MMU-1483115|reactome:R-MMU-1483166|reactome:R-MMU-2142753|reactome:R-MMU-418592|reactome:R-MMU-432142|reactome:R-MMU-6811436	afcs:15036(primary-reference)|afcs:14331(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SeaZyZCjlqkwOYE3VpELwBJXrwQ10090	rogid:3mjUfiApCMI2pQc6LflElRS9vCY10090	intact-crc:B4E210708C8A5BD1|rigid:WeaxcTjehHnfKqHRg2SlY8d444s	false	sufficient binding region:158-411	sufficient binding region:1-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35295	uniprotkb:Q9QXJ2	intact:EBI-647544|ensembl:ENSMUSP00000136957	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:purb_mouse(display_long)|uniprotkb:Purine-rich element-binding protein B(gene name synonym)|uniprotkb:Vascular actin single-stranded DNA-binding factor 2 p44 component(gene name synonym)|uniprotkb:Purb(gene name)|psi-mi:Purb(display_short)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658588	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0030154"(cell differentiation)|go:"GO:0032422"(purine-rich negative regulatory element binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSMUSG00000094483(gene)|ensembl:ENSMUST00000179343(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000900"(translation repressor activity, mRNA regulatory element binding)|go:"GO:0046332"(SMAD binding)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0000977"(RNA polymerase II transcription regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0003691"(double-stranded telomeric DNA binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006268"(DNA unwinding involved in DNA replication)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008283"(cell population proliferation)|refseq:NP_035351.1|interpro:IPR006628(PUR-alpha/beta/gamma, DNA/RNA-binding)|interpro:IPR030499|mint:O35295	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:16637(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZeoADmerELfkQ00oZ1w7a+wgQeA10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:B955D61D79AD11DA|rigid:k6vZpVmZQSH/1dPFLDLaBn9/1/g	false	sufficient binding region:188-324	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BP92	uniprotkb:Q9QXJ2	intact:EBI-642694|uniprotkb:O70341|uniprotkb:A2RT07|ensembl:ENSMUSP00000109915	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:rcn2_mouse(display_long)|uniprotkb:Taipoxin-associated calcium-binding protein 49(gene name synonym)|uniprotkb:Rcn2(gene name)|psi-mi:Rcn2(display_short)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658598	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036122.2|ensembl:ENSMUSG00000032320(gene)|ensembl:ENSMUST00000114276(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q8BP92|dip:DIP-46963N	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:18399(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:vsMMmWAPrlDNQDUxzH4wrp1Jub410090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:63AE1C4409240E09|rigid:mor5odw6S7AjTu8wcf0XTjXumY4	false	sufficient binding region:1-197	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CHH9	uniprotkb:Q9QXJ2	intact:EBI-647557|uniprotkb:Q80YC7|uniprotkb:Q9ESF7|uniprotkb:B1AQY7|ensembl:ENSMUSP00000104615	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:sept8_mouse(display_long)|uniprotkb:Septin8(gene name)|psi-mi:Septin8(display_short)|uniprotkb:Kiaa0202(gene name synonym)|uniprotkb:Sept8(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658608	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_149156.1|refseq:NP_001239261.1|refseq:NP_001239262.1|ensembl:ENSMUSG00000018398(gene)|ensembl:ENSMUST00000108987(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0003924"(GTPase activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005940"(septin ring)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030424"(axon)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0031105"(septin complex)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0032153"(cell division site)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0034613"(cellular protein localization)|go:"GO:0035542"(regulation of SNARE complex assembly)|go:"GO:0043209"(myelin sheath)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0061640"(cytoskeleton-dependent cytokinesis)|go:"GO:0098793"(presynapse)|interpro:IPR016491(Septin)|interpro:IPR027417|interpro:IPR030379|interpro:IPR030646|mint:Q8CHH9	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:20886(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8ces3FTpS8/MQKWnGkqIxiZJbBs10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:644C1CFC856B9DE6|rigid:WgWpNxqRyAXjM58D5/l3IFOgO0k	false	sufficient binding region:286-429	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QXJ2	uniprotkb:Q9JJ94	intact:EBI-646643|ensembl:ENSMUSP00000082855	intact:EBI-647574|ensembl:ENSMUSP00000028342	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:ssna1_mouse(display_long)|uniprotkb:Ssna1(gene name)|psi-mi:Ssna1(display_short)|uniprotkb:MNCb-2711(orf name)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658628	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	refseq:NP_075953.1|ensembl:ENSMUSG00000026966(gene)|ensembl:ENSMUST00000028342(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042073"(intraciliary transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0060830"(ciliary receptor clustering involved in smoothened signaling pathway)|interpro:IPR033362|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	afcs:18399(primary-reference)|afcs:24566(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	rogid:27XUjsivH0lBLAC9ePhdOlCiXps10090	intact-crc:AA09896211136A14|rigid:PsHQi3NPV0tjVo1KcFj0NycaFsk	false	sufficient binding region:1-300	sufficient binding region:66-113	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QXJ2	uniprotkb:Q499E6	intact:EBI-646643|ensembl:ENSMUSP00000082855	intact:EBI-647579|uniprotkb:Q148T1|uniprotkb:Q3TU44|uniprotkb:Q8BI05|ensembl:ENSMUSP00000154851	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:ca109_mouse(display_long)|uniprotkb:C1orf109(gene name)|psi-mi:C1orf109(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658638	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	refseq:NP_808241.2|refseq:XP_006502949.1|ensembl:ENSMUSG00000044730(gene)|ensembl:ENSMUST00000094769(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|interpro:IPR029159	afcs:18399(primary-reference)|afcs:58281(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	rogid:qALY6E/v32tcpLimzAvNcBgdFZ810090	intact-crc:4C830AE5876C27AA|rigid:dZSDZOkAkKg3Nkx19szcKxqZ+p8	false	sufficient binding region:1-300	sufficient binding region:11-91	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64705-1	uniprotkb:Q6PDN3	intact:EBI-647593|ensembl:ENSMUSP00000132256	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:q64705-1(display_long)|uniprotkb:Usf2(gene name)|psi-mi:Usf2(display_short)|uniprotkb:Major late transcription factor 2(gene name synonym)|uniprotkb:Upstream transcription factor 2(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658648	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-647583(usf2_mouse)|ensembl:ENSMUSG00000058239(gene)|ensembl:ENSMUST00000058860(transcript)	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:16919(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YLLkOCW5MB4zoW4P3KElEeRXHJU10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:E984424B791EA35C|rigid:4bOkrVOCemgSskMIFXVf5jG2bes	false	sufficient binding region:?-?	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3UIW5	uniprotkb:Q6PDN3	intact:EBI-647601|uniprotkb:Q6PDS8|uniprotkb:Q6ZQE8|uniprotkb:Q91YZ9|uniprotkb:Q9R0P0|ensembl:ENSMUSP00000107725	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:rnf10_mouse(display_long)|uniprotkb:Sid 2705(gene name synonym)|uniprotkb:Rnf10(gene name)|psi-mi:Rnf10(display_short)|uniprotkb:Kiaa0262(gene name synonym)|uniprotkb:Rie2(gene name synonym)|uniprotkb:Sid2705(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658658	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_057907.2|refseq:NP_001289377.1|refseq:NP_001289378.1|ensembl:ENSMUSG00000041740(gene)|ensembl:ENSMUST00000112096(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0010626"(negative regulation of Schwann cell proliferation)|go:"GO:0031643"(positive regulation of myelination)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099147"(extrinsic component of postsynaptic density membrane)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR039739	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:17675(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jk0OF5VoFD/Gc/fObdklFgNgIO810090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:3D1562858958D439|rigid:OJIPAAWhOp/TlgpJ8l+4LeKCTnY	false	sufficient binding region:462-804	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CCS6	uniprotkb:Q6PDN3	intact:EBI-647612|uniprotkb:O35935|ensembl:ENSMUSP00000022808	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:pabp2_mouse(display_long)|uniprotkb:"Poly(A)-binding protein II"(gene name synonym)|uniprotkb:Polyadenylate-binding nuclear protein 1(gene name synonym)|uniprotkb:"Nuclear poly(A)-binding protein 1"(gene name synonym)|uniprotkb:Pabpn1(gene name)|psi-mi:Pabpn1(display_short)|uniprotkb:Pab2(gene name synonym)|uniprotkb:Pabp2(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658668	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062275.1|reactome:R-MMU-72163|reactome:R-MMU-72187|reactome:R-MMU-73856|reactome:R-MMU-77595|ensembl:ENSMUSG00000022194(gene)|ensembl:ENSMUST00000022808(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006378"(mRNA polyadenylation)|go:"GO:0008143"("poly(A) binding")|go:"GO:0016607"(nuclear speck)|go:"GO:0016973"("poly(A)+ mRNA export from nucleus")|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043621"(protein self-association)|go:"GO:0070063"(RNA polymerase binding)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:1904247"(positive regulation of polynucleotide adenylyltransferase activity)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034911|interpro:IPR035979|mint:Q8CCS6	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:18041(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1+2pPmrrA0i20M6kR3eSl7CJSCE10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:788A9CD02D5F2F95|rigid:21nDWW+tnyVp6ydX1+lF7OK+UGw	false	sufficient binding region:103-265	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91Z31	uniprotkb:Q6PDN3	intact:EBI-647632|uniprotkb:Q7TNW7|uniprotkb:Q9CUW2|uniprotkb:Q9QYC2|uniprotkb:Q9R0V9|ensembl:ENSMUSP00000143510	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:ptbp2_mouse(display_long)|uniprotkb:Brain-enriched polypyrimidine tract-binding protein(gene name synonym)|uniprotkb:RRM-type RNA-binding protein brPTB(gene name synonym)|uniprotkb:Neural polypyrimidine tract-binding protein(gene name synonym)|uniprotkb:Ptbp2(gene name)|psi-mi:Ptbp2(display_short)|uniprotkb:Brptb(gene name synonym)|uniprotkb:Nptb(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658678	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062423.1|refseq:NP_001297640.1|ensembl:ENSMUSG00000028134(gene)|ensembl:ENSMUST00000200097(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0021510"(spinal cord development)|go:"GO:0021549"(cerebellum development)|go:"GO:0030426"(growth cone)|go:"GO:0033119"(negative regulation of RNA splicing)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034798|interpro:IPR034799|interpro:IPR034800|interpro:IPR035002|interpro:IPR035979|mint:Q91Z31	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:18131(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7kQenRcAKWB9MpwvcjsJ7MFU2u010090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:7F6FE01EE74C5220|rigid:3OoXefPokWQKo8iMf0vcrZr+iHY	false	sufficient binding region:27-193	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:E9Q5K9	uniprotkb:Q6PDN3	intact:EBI-647644|intact:EBI-8387264|intact:MINT-4119288|uniprotkb:E9PW44|uniprotkb:E9Q7Z8|uniprotkb:Q69Z54|uniprotkb:Q80V25|uniprotkb:Q8R5E6|ensembl:ENSMUSP00000039133	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:ytdc1_mouse(display_long)|uniprotkb:Ythdc1(gene name)|psi-mi:Ythdc1(display_short)|uniprotkb:Kiaa1966(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658688	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808348.2|refseq:NP_001334304.1|refseq:NP_001334305.1|ensembl:ENSMUSG00000035851(gene)|ensembl:ENSMUST00000038384(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006406"(mRNA export from nucleus)|go:"GO:0007283"(spermatogenesis)|go:"GO:0009048"(dosage compensation by inactivation of X chromosome)|go:"GO:0010608"(posttranscriptional regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0016607"(nuclear speck)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0048160"(primary follicle stage)|go:"GO:0110104"(mRNA alternative polyadenylation)|go:"GO:1990247"(N6-methyladenosine-containing RNA binding)|interpro:IPR007275(YT521-B-like protein)|mint:E9Q5K9	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:58294(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QSAdNTe3Gp42+kz7+8bzO74N9Ck10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:C974BA2278B80990|rigid:3HUcxga2mBJQd/acIaxhCSNz4NA	false	sufficient binding region:28-190	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54836	uniprotkb:P39428	intact:EBI-647650	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:zmat3_mouse(display_long)|uniprotkb:Zinc finger protein WIG-1(gene name synonym)|uniprotkb:Wild-type p53-induced gene 1 protein(gene name synonym)|uniprotkb:p53-activated gene 608 protein(gene name synonym)|uniprotkb:Zmat3(gene name)|psi-mi:Zmat3(display_short)|uniprotkb:Pag608(gene name synonym)|uniprotkb:Wig1(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658698	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR022755|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0008270"(zinc ion binding)|go:"GO:0015031"(protein transport)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0043065"(positive regulation of apoptotic process)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:15562(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:r3Pw+jmnAxuFtB87dpyW24sX+hY10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:C24F4737B0FDFDDF|rigid:z9v3jl9SCR7XYmuNfF1mnLljA40	false	sufficient binding region:38-267	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80ZI6	uniprotkb:P39428	intact:EBI-647658|ensembl:ENSMUSP00000028132|ensembl:ENSMUSP00000108825	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:lrsm1_mouse(display_long)|uniprotkb:Leucine-rich repeat and sterile alpha motif-containing protein 1(gene name synonym)|uniprotkb:Tsg101-associated ligase(gene name synonym)|uniprotkb:Lrsam1(gene name)|psi-mi:Lrsam1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase LRSAM1(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658708	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_955006.1|refseq:XP_006498032.1|refseq:XP_006498033.1|refseq:XP_006498034.1|refseq:XP_006498035.1|ensembl:ENSMUSG00000026792(gene)|ensembl:ENSMUST00000028132(transcript)|ensembl:ENSMUST00000113200(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0016020"(membrane)|go:"GO:0030163"(protein catabolic process)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0046755"(viral budding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070086"(ubiquitin-dependent endocytosis)|go:"GO:1904417"(positive regulation of xenophagy)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003591(Leucine-rich repeat, typical subtype)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR032675|reactome:R-MMU-983168	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58019(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:f3uhrAhkyTZPnMxktnsg0zqdWAU10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:FE35135092891BC7|rigid:ask3mVXkV7aXKcC6yPyE/EzPkfQ	false	sufficient binding region:148-348	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3UDK1	uniprotkb:P39428	intact:EBI-1396948|uniprotkb:Q8CFI8|ensembl:ENSMUSP00000047475	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:trad1_mouse(display_long)|uniprotkb:Protein FLN29(gene name synonym)|uniprotkb:Trafd1(gene name)|psi-mi:Trafd1(display_short)|uniprotkb:Fln29(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658718	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156942.1|refseq:NP_758479.2|refseq:XP_011246499.1|refseq:XP_006530365.1|refseq:XP_017176353.1|refseq:XP_017176354.1|refseq:XP_017176355.1|ensembl:ENSMUSG00000042726(gene)|ensembl:ENSMUST00000042312(transcript)|go:"GO:0008270"(zinc ion binding)|go:"GO:0045824"(negative regulation of innate immune response)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|mint:Q3UDK1	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58278(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uiqswqWKIeu+cpTvA7jSw/4YwdI10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:24D601F266BE9CCC|rigid:czgUYuASxI6zdGBk69+Wt5oiL58	false	sufficient binding region:151-346	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:E9QAT4	uniprotkb:P39428	intact:EBI-647676|uniprotkb:A2AIX1|uniprotkb:Q80U43|uniprotkb:Q811L5|intact:EBI-8820930|intact:EBI-10045685|intact:EBI-8573308|intact:MINT-8174146|ensembl:ENSMUSP00000088796	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:sc16a_mouse(display_long)|uniprotkb:Sec16a(gene name)|psi-mi:Sec16a(display_short)|uniprotkb:Kiaa0310(gene name synonym)|uniprotkb:SEC16 homolog A(gene name synonym)|uniprotkb:Sec16(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658728	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694765.2|refseq:XP_006497974.1|ensembl:ENSMUSG00000026924(gene)|ensembl:ENSMUST00000091252(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006914"(autophagy)|go:"GO:0007029"(endoplasmic reticulum organization)|go:"GO:0007030"(Golgi organization)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0031090"(organelle membrane)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0043000"(Golgi to plasma membrane CFTR protein transport)|go:"GO:0048208"(COPII vesicle coating)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050821"(protein stabilization)|go:"GO:0070863"(positive regulation of protein exit from endoplasmic reticulum)|go:"GO:0070971"(endoplasmic reticulum exit site)|go:"GO:0070973"(protein localization to endoplasmic reticulum exit site)|go:"GO:0072659"(protein localization to plasma membrane)|interpro:IPR024298|interpro:IPR024340|interpro:IPR024880|mint:E9QAT4|reactome:R-MMU-204005|go:"GO:0032527"(protein exit from endoplasmic reticulum)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58282(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2019/01/25	rogid:97WhpZFikynLgEykn8l5NJODOpo10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:94C5E35FE246158A|rigid:BXDG/mNQCzVDKig4rug1vV/lIcQ	false	sufficient binding region:164-304	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q924T7	uniprotkb:P39428	intact:EBI-647680|ensembl:ENSMUSP00000019443	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:rnf31_mouse(display_long)|uniprotkb:HOIL-1-interacting protein(gene name synonym)|uniprotkb:Rnf31(gene name)|psi-mi:Rnf31(display_short)|uniprotkb:Paul(gene name synonym)|uniprotkb:Putative Ariadne-like ubiquitin ligase(gene name synonym)|uniprotkb:RING finger protein 31(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF31(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658738	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_919327.2|dip:DIP-49579N|reactome:R-MMU-5357905|reactome:R-MMU-5357956|rcsb pdb:5Y3T|ensembl:ENSMUSG00000047098(gene)|ensembl:ENSMUST00000019443(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002867(Zinc finger, C6HC-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR018997|interpro:IPR026254|interpro:IPR032065|interpro:IPR036339|interpro:IPR036443|interpro:IPR040641|interpro:IPR041031|interpro:IPR044066	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58295(secondary-ac)	-	-	caution:The prey construct contains 25 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:xIbE6XjFXsobrXWbjabTL3rhhf410090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:0D2065636FDBC375|rigid:E7OB0rLM57WBSm1g+wwi++Wjau4	false	sufficient binding region:1-306	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P21460	uniprotkb:Q9Z2A0	intact:EBI-642162|uniprotkb:Q544Y0|ensembl:ENSMUSP00000028938	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:cytc_mouse(display_long)|uniprotkb:Cystatin-3(gene name synonym)|uniprotkb:Cst3(gene name)|psi-mi:Cst3(display_short)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649318	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034106.2|go:"GO:0031982"(vesicle)|go:"GO:0032355"(response to estradiol)|go:"GO:0042493"|go:"GO:0042747"(circadian sleep/wake cycle, REM sleep)|go:"GO:0042802"(identical protein binding)|go:"GO:0042995"(cell projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043067"(regulation of programmed cell death)|go:"GO:0043292"(contractile fiber)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0060009"(Sertoli cell development)|go:"GO:0060311"(negative regulation of elastin catabolic process)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0097435"(supramolecular fiber organization)|interpro:IPR000010(Proteinase inhibitor I25, cystatin)|interpro:IPR018073|mint:P21460|reactome:R-MMU-381426|reactome:R-MMU-6798695|reactome:R-MMU-8957275|go:"GO:0031965"(nuclear membrane)|ensembl:ENSMUSG00000027447(gene)|ensembl:ENSMUST00000028938(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001654"(eye development)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001775"(cell activation)|go:"GO:0002020"(protease binding)|go:"GO:0004866"(endopeptidase inhibitor activity)|go:"GO:0004869"(cysteine-type endopeptidase inhibitor activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005604"(basement membrane)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005771"(multivesicular body)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006915"(apoptotic process)|go:"GO:0006952"(defense response)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007420"(brain development)|go:"GO:0007431"(salivary gland development)|go:"GO:0007566"(embryo implantation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010466"(negative regulation of peptidase activity)|go:"GO:0030414"(peptidase inhibitor activity)|go:"GO:0030424"(axon)|go:"GO:0031667"(response to nutrient levels)	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:15876(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QukDaHiP8DQMaHOqRQkMHU3LrMU10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:CB9FF4DCFBAA9979|rigid:LwNR1I3nvZfW1yvMN1vjCc7cgBU	false	sufficient binding region:1-130	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P68033	uniprotkb:Q9Z2A0	intact:EBI-352284|uniprotkb:P04270|ensembl:ENSMUSP00000087736	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:actc_mouse(display_long)|uniprotkb:Actc1(gene name)|psi-mi:Actc1(display_short)|uniprotkb:Actc(gene name synonym)|uniprotkb:Alpha-cardiac actin(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649339	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033738.1|ensembl:ENSMUSG00000068614(gene)|ensembl:ENSMUST00000090269(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0007015"(actin filament organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0033275"(actin-myosin filament sliding)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070252"(actin-mediated cell contraction)|go:"GO:0090131"(mesenchyme migration)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P68033|reactome:R-MMU-390522|reactome:R-MMU-8980692|reactome:R-MMU-9013026	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:23582(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U/lKYqWUWMSC3fBHFaAcgzfk+3w10090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:EBD1A422F25ADB65|rigid:y9AQY/8ho0rsRZa0t5NepDXJ+JY	false	sufficient binding region:5-377	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P68033	uniprotkb:P35991	intact:EBI-352284|uniprotkb:P04270|ensembl:ENSMUSP00000087736	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:actc_mouse(display_long)|uniprotkb:Actc1(gene name)|psi-mi:Actc1(display_short)|uniprotkb:Actc(gene name synonym)|uniprotkb:Alpha-cardiac actin(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649349	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033738.1|ensembl:ENSMUSG00000068614(gene)|ensembl:ENSMUST00000090269(transcript)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005869"(dynactin complex)|go:"GO:0005884"(actin filament)|go:"GO:0007015"(actin filament organization)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0017022"(myosin binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030027"(lamellipodium)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0030175"(filopodium)|go:"GO:0030240"(skeletal muscle thin filament assembly)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0031674"(I band)|go:"GO:0033275"(actin-myosin filament sliding)|go:"GO:0042493"|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0045471"(response to ethanol)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0055008"(cardiac muscle tissue morphogenesis)|go:"GO:0060047"(heart contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0070252"(actin-mediated cell contraction)|go:"GO:0090131"(mesenchyme migration)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR004000(Actin/actin-like)|interpro:IPR004001(Actin, conserved site)|interpro:IPR020902|interpro:IPR043129|mint:P68033|reactome:R-MMU-390522|reactome:R-MMU-8980692|reactome:R-MMU-9013026	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:23582(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U/lKYqWUWMSC3fBHFaAcgzfk+3w10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:A88137681AE72AD8|rigid:apUriSc3wSrRstgebniTrAr+TgA	false	sufficient binding region:36-325	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P05064	uniprotkb:P35991	intact:EBI-494220|ensembl:ENSMUSP00000032934|ensembl:ENSMUSP00000101955	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:aldoa_mouse(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Aldolase 1(gene name synonym)|uniprotkb:Aldoa(gene name)|psi-mi:Aldoa(display_short)|uniprotkb:Aldo1(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649423	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006507273.1|refseq:XP_006507274.1|refseq:NP_001170779.1|refseq:NP_031464.1|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031430"(M band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061827"(sperm head)|go:"GO:0005886"(plasma membrane)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|ensembl:ENSMUSG00000030695(gene)|ensembl:ENSMUST00000032934(transcript)|ensembl:ENSMUST00000106348(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0002020"(protease binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|mint:P05064|reactome:R-MMU-114608|reactome:R-MMU-6798695|reactome:R-MMU-70171|reactome:R-MMU-70263|interpro:IPR029768	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:13808(secondary-ac)|afcs:17216(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:m116/AX8vWkh1JCGOnEZv9ZOU9010090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:20B623A885F41C34|rigid:Z3O9V464TEcpWF/7ocNjRKEEToI	false	sufficient binding region:229-364	sufficient binding region:210-402	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P05064	uniprotkb:Q9Z2A0	intact:EBI-494220|ensembl:ENSMUSP00000032934|ensembl:ENSMUSP00000101955	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:aldoa_mouse(display_long)|uniprotkb:Muscle-type aldolase(gene name synonym)|uniprotkb:Aldolase 1(gene name synonym)|uniprotkb:Aldoa(gene name)|psi-mi:Aldoa(display_short)|uniprotkb:Aldo1(gene name synonym)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649434	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006507273.1|refseq:XP_006507274.1|refseq:NP_001170779.1|refseq:NP_031464.1|go:"GO:0006000"(fructose metabolic process)|go:"GO:0006096"(glycolytic process)|go:"GO:0006754"(ATP biosynthetic process)|go:"GO:0006941"(striated muscle contraction)|go:"GO:0007339"(binding of sperm to zona pellucida)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0019242"(methylglyoxal biosynthetic process)|go:"GO:0030018"(Z disc)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030388"(fructose 1,6-bisphosphate metabolic process)|go:"GO:0031430"(M band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035686"(sperm fibrous sheath)|go:"GO:0042802"(identical protein binding)|go:"GO:0043209"(myelin sheath)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0061615"(glycolytic process through fructose-6-phosphate)|go:"GO:0061827"(sperm head)|go:"GO:0005886"(plasma membrane)|go:"GO:0070061"(fructose binding)|go:"GO:0070062"(extracellular exosome)|interpro:IPR000741(Fructose-bisphosphate aldolase, class-I)|interpro:IPR013785(Aldolase-type TIM barrel)|ensembl:ENSMUSG00000030695(gene)|ensembl:ENSMUST00000032934(transcript)|ensembl:ENSMUST00000106348(transcript)|go:"GO:0000792"(heterochromatin)|go:"GO:0002020"(protease binding)|go:"GO:0004332"(fructose-bisphosphate aldolase activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|mint:P05064|reactome:R-MMU-114608|reactome:R-MMU-6798695|reactome:R-MMU-70171|reactome:R-MMU-70263|interpro:IPR029768	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:13808(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:m116/AX8vWkh1JCGOnEZv9ZOU9010090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:BE81D9FE5781CBB8|rigid:GMZPe0HRvCg09gNagPW0Lh4qVmk	false	sufficient binding region:37-282	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70433	uniprotkb:Q8CIH5	intact:EBI-299379|ensembl:ENSMUSP00000008280|ensembl:ENSMUSP00000141170|uniprotkb:P97448	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:fhl2_mouse(display_long)|uniprotkb:Fhl2(gene name)|psi-mi:Fhl2(display_short)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649644	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000008136(gene)|ensembl:ENSMUST00000008280(transcript)|ensembl:ENSMUST00000185893(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|refseq:NP_034342.1|refseq:XP_011236736.1|refseq:NP_001276462.1	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:16014(secondary-ac)	-	-	caution:The prey construct contains 3 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:F/ksOc8Ay71/DwSdKCK0mehHCCs10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:29D9F0385024B09C|rigid:9/MD9xLlvu5MA9dp52mVE43ciUs	false	sufficient binding region:1-279	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70433	uniprotkb:Q8CIH5	intact:EBI-299379|ensembl:ENSMUSP00000008280|ensembl:ENSMUSP00000141170|uniprotkb:P97448	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:fhl2_mouse(display_long)|uniprotkb:Fhl2(gene name)|psi-mi:Fhl2(display_short)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649655	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000008136(gene)|ensembl:ENSMUST00000008280(transcript)|ensembl:ENSMUST00000185893(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|refseq:NP_034342.1|refseq:XP_011236736.1|refseq:NP_001276462.1	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:16014(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:F/ksOc8Ay71/DwSdKCK0mehHCCs10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:28C0D310F4D318C4|rigid:9/MD9xLlvu5MA9dp52mVE43ciUs	false	sufficient binding region:124-279	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70433	uniprotkb:Q8CIH5	intact:EBI-299379|ensembl:ENSMUSP00000008280|ensembl:ENSMUSP00000141170|uniprotkb:P97448	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:fhl2_mouse(display_long)|uniprotkb:Fhl2(gene name)|psi-mi:Fhl2(display_short)|uniprotkb:Skeletal muscle LIM-protein 3(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-649665	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000008136(gene)|ensembl:ENSMUST00000008280(transcript)|ensembl:ENSMUST00000185893(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008134"(transcription factor binding)|go:"GO:0009725"(response to hormone)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043425"(bHLH transcription factor binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0055014"(atrial cardiac muscle cell development)|go:"GO:0055015"(ventricular cardiac muscle cell development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0070885"(negative regulation of calcineurin-NFAT signaling cascade)|interpro:IPR001781(Zinc finger, LIM-type)|interpro:IPR037987|refseq:NP_034342.1|refseq:XP_011236736.1|refseq:NP_001276462.1	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:16014(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:F/ksOc8Ay71/DwSdKCK0mehHCCs10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:E2500119BD31249E|rigid:9/MD9xLlvu5MA9dp52mVE43ciUs	false	sufficient binding region:131-279	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P23927	uniprotkb:Q8CIH5	intact:EBI-299046|ensembl:ENSMUSP00000034562|ensembl:ENSMUSP00000149759|ensembl:ENSMUSP00000149803|ensembl:ENSMUSP00000150669|uniprotkb:Q64325	intact:EBI-617954|ensembl:ENSMUSP00000079991|uniprotkb:Q3UBA8|uniprotkb:Q3UQT0|uniprotkb:Q8VE69	psi-mi:cryab_mouse(display_long)|uniprotkb:Cryab(gene name)|psi-mi:Cryab(display_short)|uniprotkb:Crya2(gene name synonym)|uniprotkb:"Alpha(B)-crystallin"(gene name synonym)|uniprotkb:P23(gene name synonym)	psi-mi:plcg2_mouse(display_long)|uniprotkb:Phosphoinositide phospholipase C-gamma-2(gene name synonym)|uniprotkb:Phospholipase C-gamma-2(gene name synonym)|uniprotkb:Plcg2(gene name)|psi-mi:Plcg2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650460	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000032060(gene)|ensembl:ENSMUST00000034562(transcript)|ensembl:ENSMUST00000214962(transcript)|ensembl:ENSMUST00000216755(transcript)|ensembl:ENSMUST00000217475(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043292"(contractile fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR003090(Alpha-crystallin, N-terminal)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037882|mint:P23927|reactome:R-MMU-3371571|refseq:XP_006510033.1|refseq:NP_034094.1|refseq:NP_001276711.1|refseq:NP_001276713.1|refseq:NP_001276714.1|dip:DIP-31060N	ensembl:ENSMUSG00000034330(gene)|ensembl:ENSMUST00000081232(transcript)|go:"GO:0001775"(cell activation)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001878"(response to yeast)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002223"(stimulatory C-type lectin receptor signaling pathway)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002281"(macrophage activation involved in immune response)|go:"GO:0002316"(follicular B cell differentiation)|go:"GO:0002732"(positive regulation of dendritic cell cytokine production)|go:"GO:0004435"(phosphatidylinositol phospholipase C activity)|go:"GO:0004629"(phospholipase C activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0009395"(phospholipid catabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032747"(positive regulation of interleukin-23 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032237"(activation of store-operated calcium channel activity)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032959"(inositol trisphosphate biosynthetic process)|go:"GO:0033198"(response to ATP)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043069"(negative regulation of programmed cell death)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050850"(positive regulation of calcium-mediated signaling)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0060907"(positive regulation of macrophage cytokine production)|go:"GO:0061760"(antifungal innate immune response)|go:"GO:0070884"(regulation of calcineurin-NFAT signaling cascade)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097708"(intracellular vesicle)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:0150078"(positive regulation of neuroinflammatory response)|go:"GO:1900227"(positive regulation of NLRP3 inflammasome complex assembly)|go:"GO:1902808"(positive regulation of cell cycle G1/S phase transition)|go:"GO:1903428"(positive regulation of reactive oxygen species biosynthetic process)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:1990858"(cellular response to lectin)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR000909(Phospholipase C, phosphatidylinositol-specific , X region)|interpro:IPR000980(SH2 motif)|interpro:IPR001192("Phospholipase C, phosphoinositol-specific, C-terminal (PLC)")|interpro:IPR001452(Src homology-3)|interpro:IPR001711(Phospholipase C, phosphatidylinositol-specific, Y domain)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011992(EF-Hand type)|interpro:IPR035723|interpro:IPR035892|interpro:IPR036028|interpro:IPR036860|mint:Q8CIH5|rcsb pdb:2DX0|rcsb pdb:2EQI|reactome:R-MMU-114604|reactome:R-MMU-166016|reactome:R-MMU-1855204|reactome:R-MMU-202433|reactome:R-MMU-2029485|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-5607764|reactome:R-MMU-5621480|reactome:R-MMU-983695|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016279(Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase gamma)|interpro:IPR017946|interpro:IPR028381|interpro:IPR035023|interpro:IPR035024|refseq:NP_758489.1|dip:DIP-33368N	afcs:22821(primary-reference)|afcs:15868(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LOp5smbeRceV8/P+Eaoh7p+24Vw10090	rogid:YEhKUFDqvqqaUleIfGwQ4JUeIGY10090	intact-crc:9DBF44E0816819EE|rigid:21y6XHmjHxUayQuMzpRiqW1XuHY	false	sufficient binding region:22-175	sufficient binding region:450-835	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01768	uniprotkb:P26450	intact:EBI-642573|ensembl:ENSMUSP00000021217|ensembl:ENSMUSP00000103476	intact:EBI-641764|uniprotkb:Q8K3B3|ensembl:ENSMUSP00000056774	psi-mi:ndkb_mouse(display_long)|uniprotkb:nm23-M2(gene name synonym)|uniprotkb:P18(gene name synonym)|uniprotkb:Nme2(gene name)|psi-mi:Nme2(display_short)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:p85a_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha(gene name synonym)|uniprotkb:Pik3r1(gene name)|psi-mi:Pik3r1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651983	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070997.1|refseq:NP_032731.1|ensembl:ENSMUSG00000020857(gene)|ensembl:ENSMUST00000021217(transcript)|ensembl:ENSMUST00000072566(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1901363"(heterocyclic compound binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q01768|reactome:R-MMU-499943|reactome:R-MMU-6798695	refseq:NP_001070963.1|dip:DIP-39593N|reactome:R-MMU-5654720|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|reactome:R-MMU-9027276|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9696264|ensembl:ENSMUSG00000041417(gene)|ensembl:ENSMUST00000055518(transcript)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0001953"(negative regulation of cell-matrix adhesion)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005801"(cis-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0005943"(phosphatidylinositol 3-kinase complex, class IA)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007162"(negative regulation of cell adhesion)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0008625"(extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0010459"(negative regulation of heart rate)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010656"(negative regulation of muscle cell apoptotic process)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016303"(1-phosphatidylinositol-3-kinase activity)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030183"(B cell differentiation)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043559"(insulin binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045776"(negative regulation of blood pressure)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046626"(regulation of insulin receptor signaling pathway)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051117"(ATPase binding)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051384"(response to glucocorticoid)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0051591"(response to cAMP)|go:"GO:0051965"(positive regulation of synapse assembly)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|go:"GO:1900103"(positive regulation of endoplasmic reticulum unfolded protein response)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1990578"(perinuclear endoplasmic reticulum membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035591|interpro:IPR036028|interpro:IPR036860|interpro:IPR044124|mint:P26450|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1250342|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|go:"GO:0043125"(ErbB-3 class receptor binding)|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-1963642|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-430116|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033120"(positive regulation of RNA splicing)|go:"GO:0034644"(cellular response to UV)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035014"(phosphatidylinositol 3-kinase regulator activity)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0043005"(neuron projection)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0030335"(positive regulation of cell migration)|reactome:R-MMU-9696273|reactome:R-MMU-983695|reactome:R-MMU-9696270	afcs:52679(primary-reference)|afcs:7069(secondary-ac)	-	-	caution:The prey construct contains 4 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AJ1Depmyy9zwTEUOZMRO7TKPd1k10090	rogid:4pDYhQfVq5ytTuxu8YtWABiSLQw10090	intact-crc:14CDD1B1B9E9AE79|rigid:OuB3NSY9PWfFsZmsVA71U0L76js	false	sufficient binding region:1-152	sufficient binding region:1-251	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z179	uniprotkb:P98083	intact:EBI-644352|uniprotkb:Q3UED9|uniprotkb:Q3UMD9|ensembl:ENSMUSP00000022945	intact:EBI-300201|ensembl:ENSMUSP00000091940|uniprotkb:Q3U2Q7|uniprotkb:Q8BFY3|uniprotkb:Q8K4C6|uniprotkb:Q8K4C7	psi-mi:shcbp_mouse(display_long)|uniprotkb:Protein expressed in activated lymphocytes(gene name synonym)|uniprotkb:SHC-binding protein(gene name synonym)|uniprotkb:Shcbp1(gene name)|psi-mi:Shcbp1(display_short)|uniprotkb:Pal(gene name synonym)	psi-mi:shc1_mouse(display_long)|uniprotkb:ShcA(gene name synonym)|uniprotkb:Shc1(gene name)|psi-mi:Shc1(display_short)|uniprotkb:Shc(gene name synonym)|uniprotkb:Src homology 2 domain-containing-transforming protein C1(gene name synonym)|uniprotkb:SHC-transforming protein A(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652065	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035499.1|ensembl:ENSMUSG00000022322(gene)|ensembl:ENSMUST00000022945(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005819"(spindle)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0042169"(SH2 domain binding)|go:"GO:2000177"(regulation of neural precursor cell proliferation)|interpro:IPR006626(Parallel beta-helix repeat)|interpro:IPR011050(Pectin lyase fold/virulence factor)|interpro:IPR012334(Pectin lyase fold)|interpro:IPR039448	ensembl:ENSMUST00000094378(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005759"(mitochondrial matrix)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006940"(regulation of smooth muscle contraction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008286"(insulin receptor signaling pathway)|ensembl:ENSMUSG00000042626(gene)|go:"GO:0010008"(endosome membrane)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0040008"(regulation of growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045907"(positive regulation of vasoconstriction)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048408"(epidermal growth factor binding)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051721"(protein phosphatase 2A binding)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0070435"(Shc-EGFR complex)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|mint:P98083|reactome:R-MMU-1250196|reactome:R-MMU-1250347|reactome:R-MMU-167044|reactome:R-MMU-180336|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2428933|go:"GO:0090322"(regulation of superoxide metabolic process)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1990839"(response to endothelin)|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354192|reactome:R-MMU-512988|reactome:R-MMU-5654688|reactome:R-MMU-5654699|reactome:R-MMU-5654704|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|interpro:IPR000980(SH2 motif)|reactome:R-MMU-8851805|reactome:R-MMU-8853659|interpro:IPR006019("Phosphotyrosine interaction (PID or PI)")|reactome:R-MMU-8983432|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029586|interpro:IPR035676|interpro:IPR036860|reactome:R-MMU-9009391|reactome:R-MMU-9020558|reactome:R-MMU-9027284|reactome:R-MMU-9674555|reactome:R-MMU-912526|refseq:NP_001106802.1|refseq:NP_035498.2|dip:DIP-271N	afcs:6875(primary-reference)|afcs:16731(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MgcPGnEzLfUPCtS+m+6NJ4Yyr2k10090	rogid:BksNa7XxzDyhK8y6ZdU5tz9CLUU10090	intact-crc:EF2D2A92ADE8AE2B|rigid:J4QPdBrChXQdBwLoyulvqNyg/do	false	sufficient binding region:66-569	sufficient binding region:350-577	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BTX4	uniprotkb:P35991	intact:EBI-643390	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:q8btx4_mouse(display_long)|uniprotkb:Nop53(gene name)|psi-mi:Nop53(display_short)|uniprotkb:Gltscr2(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650901	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR011687(P60-like)|go:"GO:0000027"(ribosomal large subunit assembly)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:34962(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bu7hQQ5E7NDZJcYnYWfKA9IMJvs10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:9CD7951FB142378D|rigid:RJi/p5ONMfz9e9L1Na9HnqEiR80	false	sufficient binding region:348-474	sufficient binding region:210-280	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5SUF2	uniprotkb:P35991	intact:EBI-643396|uniprotkb:Q3U9D5|uniprotkb:Q8BUJ5|uniprotkb:Q921Z3|uniprotkb:Q9CRS7|uniprotkb:Q9CTY4|ensembl:ENSMUSP00000103450|ensembl:ENSMUSP00000103451	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:lc7l3_mouse(display_long)|uniprotkb:Luc7l3(gene name)|psi-mi:Luc7l3(display_short)|uniprotkb:Crop(gene name synonym)|uniprotkb:Cisplatin resistance-associated-overexpressed protein(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650911	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080589.1|refseq:XP_006534073.1|refseq:XP_006534074.1|ensembl:ENSMUSG00000020863(gene)|ensembl:ENSMUST00000107820(transcript)|ensembl:ENSMUST00000107821(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(primary-reference)|afcs:34957(secondary-ac)	-	-	caution:The prey construct contains 7 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:pb8JxU2FNO7WcXwgcRr4kx9hVbI10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:B19101030584CA83|rigid:tHv4l177vDne4705/ryU76mEaQ4	false	sufficient binding region:1-165	sufficient binding region:210-280	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P83917	uniprotkb:P35991	intact:EBI-78119|uniprotkb:P23197|ensembl:ENSMUSP00000091475	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:cbx1_mouse(display_long)|uniprotkb:Cbx1(gene name)|psi-mi:Cbx1(display_short)|uniprotkb:Cbx(gene name synonym)|uniprotkb:Heterochromatin protein 1 homolog beta(gene name synonym)|uniprotkb:Modifier 1 protein(gene name synonym)|uniprotkb:M31(gene name synonym)|uniprotkb:Heterochromatin protein p25(gene name synonym)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650921	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000018666(gene)|ensembl:ENSMUST00000093943(transcript)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0001939"(female pronucleus)|go:"GO:0001940"(male pronucleus)|go:"GO:0005634"(nucleus)|go:"GO:0005721"(pericentric heterochromatin)|go:"GO:0005819"(spindle)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010369"(chromocenter)|go:"GO:0019899"(enzyme binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0090734"(site of DNA damage)|go:"GO:1990226"(histone methyltransferase binding)|interpro:IPR000953(Chromo domain)|interpro:IPR008251(Chromo shadow)|interpro:IPR016197(Chromo domain-like)|interpro:IPR017984|interpro:IPR023779|interpro:IPR023780|mint:P83917|rcsb pdb:1AP0|rcsb pdb:1DZ1|rcsb pdb:1GUW|rcsb pdb:1S4Z|refseq:NP_031648.1|refseq:XP_006532162.1|refseq:XP_006532163.1|refseq:XP_011247006.1|refseq:XP_017169731.1|dip:DIP-30892N	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:17216(secondary-ac)|afcs:17216(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:W2npW/vFRcuTkStKpknsAP69q6I10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:A39BBFB988053C28|rigid:TCrF2mhCLKWIQ/cx9huMruZ/PZY	false	sufficient binding region:1-94	sufficient binding region:210-280	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VDV8	uniprotkb:Q99N72	intact:EBI-643403|uniprotkb:Q9DB13|ensembl:ENSMUSP00000027257|ensembl:ENSMUSP00000123009	intact:EBI-641874	psi-mi:mitd1_mouse(display_long)|uniprotkb:Mitd1(gene name)|psi-mi:Mitd1(display_short)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650941	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081189.1|ensembl:ENSMUSG00000026088(gene)|ensembl:ENSMUST00000027257(transcript)|ensembl:ENSMUST00000139725(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030496"(midbody)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0061952"(midbody abscission)|interpro:IPR007330(MIT)|interpro:IPR032341|interpro:IPR036181|interpro:IPR038113|rcsb pdb:1WFD	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:34966(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:zp0JVHvcgsivbtVef5vwyBwuIhA10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:4F592C24F252432B|rigid:QFyyGHS1vPpi6On2hJ/+XTRmksg	false	sufficient binding region:61-249	sufficient binding region:218-490	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61233	uniprotkb:Q99N72	intact:EBI-309345|uniprotkb:Q3UE24|uniprotkb:Q8R1X3|uniprotkb:Q9CV77|ensembl:ENSMUSP00000116271|ensembl:ENSMUSP00000117137|ensembl:ENSMUSP00000121201	intact:EBI-641874	psi-mi:plsl_mouse(display_long)|uniprotkb:Lcp1(gene name)|psi-mi:Lcp1(display_short)|uniprotkb:Pls2(gene name synonym)|uniprotkb:L-plastin(gene name synonym)|uniprotkb:Lymphocyte cytosolic protein 1(gene name synonym)|uniprotkb:65 kDa macrophage protein(gene name synonym)|uniprotkb:pp65(gene name synonym)	psi-mi:q99n72_mouse(display_long)|uniprotkb:Mcf2(gene name)|psi-mi:Mcf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650952	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032905.2|refseq:XP_006518762.1|refseq:XP_006518764.1|refseq:XP_006518765.1|refseq:XP_006518766.1|refseq:XP_006518767.1|refseq:NP_001234913.1|go:"GO:0009611"(response to wounding)|go:"GO:0010737"(protein kinase A signaling)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016477"(cell migration)|go:"GO:0022617"(extracellular matrix disassembly)|go:"GO:0030175"(filopodium)|go:"GO:0031100"(animal organ regeneration)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051015"(actin filament binding)|go:"GO:0051017"(actin filament bundle assembly)|go:"GO:0051020"(GTPase binding)|go:"GO:0051639"(actin filament network formation)|go:"GO:0071803"(positive regulation of podosome assembly)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR036872|interpro:IPR039956|interpro:IPR039959|mint:Q61233|ensembl:ENSMUSG00000021998(gene)|ensembl:ENSMUST00000124499(transcript)|ensembl:ENSMUST00000131802(transcript)|ensembl:ENSMUST00000145303(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0001726"(ruffle)|go:"GO:0001891"(phagocytic cup)|go:"GO:0002102"(podosome)|go:"GO:0002286"(T cell activation involved in immune response)|go:"GO:0005178"(integrin binding)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|refseq:XP_017171409.1	interpro:IPR001251(Cellular retinaldehyde-binding/triple function, C-terminal)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|go:"GO:0016358"(dendrite development)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|interpro:IPR035899	afcs:23263(primary-reference)|afcs:15044(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:kU9t6rNcFG1BiDoIuP1LuaUYl7I10090	rogid:sHXnu3xRnAzO32Q1Pz4wmj+ZfxE10090	intact-crc:9AB2739AF4D8BE15|rigid:PwrYMzQDmnQ8s368y+Dxsc24Sio	false	sufficient binding region:59-374	sufficient binding region:218-490	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P56477	uniprotkb:Q60591	intact:EBI-643408|ensembl:ENSMUSP00000004392|ensembl:ENSMUSP00000127021	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:irf5_mouse(display_long)|uniprotkb:Irf5(gene name)|psi-mi:Irf5(display_short)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650962	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036187.1|refseq:NP_001239311.1|refseq:XP_006505160.1|ensembl:ENSMUSG00000029771(gene)|ensembl:ENSMUST00000004392(transcript)|ensembl:ENSMUST00000163511(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR029838|interpro:IPR036388|interpro:IPR036390|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|dip:DIP-49382N	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	afcs:53032(primary-reference)|afcs:17187(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Mdz1n0MUvYYjxamfbVAzdusN1M810090	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	intact-crc:EFC89EB7BA22AEDF|rigid:V7DbH63nwta9wuiLEkuv5jJAbnQ	false	sufficient binding region:163-390	sufficient binding region:200-420	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P56477	uniprotkb:Q60591	intact:EBI-643408|ensembl:ENSMUSP00000004392|ensembl:ENSMUSP00000127021	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:irf5_mouse(display_long)|uniprotkb:Irf5(gene name)|psi-mi:Irf5(display_short)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650972	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036187.1|refseq:NP_001239311.1|refseq:XP_006505160.1|ensembl:ENSMUSG00000029771(gene)|ensembl:ENSMUST00000004392(transcript)|ensembl:ENSMUST00000163511(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006954"(inflammatory response)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032481"(positive regulation of type I interferon production)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0042802"(identical protein binding)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051607"(defense response to virus)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR029838|interpro:IPR036388|interpro:IPR036390|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|dip:DIP-49382N	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	afcs:53032(primary-reference)|afcs:17187(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Mdz1n0MUvYYjxamfbVAzdusN1M810090	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	intact-crc:134C0613ED423033|rigid:V7DbH63nwta9wuiLEkuv5jJAbnQ	false	sufficient binding region:164-390	sufficient binding region:200-420	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BUN3	uniprotkb:Q60591	intact:EBI-643414|ensembl:ENSMUSP00000141267	intact:EBI-643104|uniprotkb:B5B2Q3|uniprotkb:A2APK2|uniprotkb:A2APK3|uniprotkb:A2AQC5|uniprotkb:A2AQC6|uniprotkb:A2AQC7|uniprotkb:Q91Y65|uniprotkb:Q60984|uniprotkb:Q60985|ensembl:ENSMUSP00000074198	psi-mi:q8bun3_mouse(display_long)|uniprotkb:Qrich1(gene name)|psi-mi:Qrich1(display_short)	psi-mi:nfac2_mouse(display_long)|uniprotkb:T-cell transcription factor NFAT1(gene name synonym)|uniprotkb:NFAT pre-existing subunit(gene name synonym)|uniprotkb:Nfatc2(gene name)|psi-mi:Nfatc2(display_short)|uniprotkb:Nfat1(gene name synonym)|uniprotkb:Nfatp(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650992	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000006673(gene)|ensembl:ENSMUST00000193258(transcript)	refseq:NP_035029.2|ensembl:ENSMUSG00000027544(gene)|ensembl:ENSMUST00000074618(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0042493"|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:1905064"(negative regulation of vascular associated smooth muscle cell differentiation)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR002909(Cell surface receptor IPT/TIG)|interpro:IPR008366("Nuclear factor of activated T cells (NFAT)")|go:"GO:0005634"(nucleus)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|go:"GO:0005654"(nucleoplasm)|interpro:IPR011539(Rel homology)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR032397|interpro:IPR037059|reactome:R-MMU-2025928|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|reactome:R-MMU-2871809|reactome:R-MMU-5607763|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0014904"(myotube cell development)|go:"GO:0016477"(cell migration)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0033173"(calcineurin-NFAT signaling cascade)|dip:DIP-49476N	afcs:53032(primary-reference)|afcs:34961(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Fk+VPdJcSUYtuypfWyU3ccZODl410090	rogid:IKjLThZZ/+mxINbj5q5+R2GddJo10090	intact-crc:0E652AAD1916E870|rigid:s+yu9n/oOKXRtCipGDQkXcsPUMA	false	sufficient binding region:63-432	sufficient binding region:200-420	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D892	uniprotkb:Q9ES28	intact:EBI-643418|uniprotkb:Q8R0Q8|ensembl:ENSMUSP00000099482	intact:EBI-642580|uniprotkb:O08757|uniprotkb:Q3UTS5|uniprotkb:Q6XPA5|uniprotkb:Q6ZQI5|uniprotkb:Q8C750|uniprotkb:Q91ZZ6|uniprotkb:Q9ES27	psi-mi:itpa_mouse(display_long)|uniprotkb:Itpa(gene name)|psi-mi:Itpa(display_short)|uniprotkb:Non-canonical purine NTP pyrophosphatase(gene name synonym)|uniprotkb:Non-standard purine NTP pyrophosphatase(gene name synonym)|uniprotkb:Nucleoside-triphosphate diphosphatase(gene name synonym)|uniprotkb:Nucleoside-triphosphate pyrophosphatase(gene name synonym)	psi-mi:arhg7_mouse(display_long)|uniprotkb:PAK-interacting exchange factor beta(gene name synonym)|uniprotkb:Beta-Pix(gene name synonym)|uniprotkb:p85SPR(gene name synonym)|uniprotkb:Arhgef7(gene name)|psi-mi:Arhgef7(display_short)|uniprotkb:Pak3bp(gene name synonym)|uniprotkb:Kiaa0142(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651002	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080198.2|go:"GO:0005829"(cytosol)|go:"GO:0006193"(ITP catabolic process)|go:"GO:0009143"(nucleoside triphosphate catabolic process)|go:"GO:0009204"(deoxyribonucleoside triphosphate catabolic process)|go:"GO:0035529"(NADH pyrophosphatase activity)|go:"GO:0035870"(dITP diphosphatase activity)|go:"GO:0036218"(dTTP diphosphatase activity)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0046872"(metal ion binding)|go:"GO:0047429"(nucleoside-triphosphate diphosphatase activity)|go:"GO:0051276"(chromosome organization)|interpro:IPR002637(Ham1-like protein)|interpro:IPR027502|interpro:IPR029001|mint:Q9D892|reactome:R-MMU-74259|go:"GO:0005737"(cytoplasm)|ensembl:ENSMUSG00000074797(gene)|ensembl:ENSMUST00000103193(transcript)|go:"GO:0000166"(nucleotide binding)|go:"GO:0005654"(nucleoplasm)|refseq:XP_017171220.1	refseq:NP_001106989.1|refseq:NP_001106990.1|refseq:NP_059098.2|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001452(Src homology-3)|refseq:XP_006508906.2|refseq:XP_006508907.2|interpro:IPR032409|refseq:XP_006508904.2|reactome:R-MMU-416482|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013406|reactome:R-MMU-9013420|reactome:R-MMU-9013424|go:"GO:0000322"(storage vacuole)|go:"GO:0001726"(ruffle)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007030"(Golgi organization)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030426"(growth cone)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0043005"(neuron projection)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0043615"(astrocyte cell migration)|go:"GO:0060124"(positive regulation of growth hormone secretion)|go:"GO:0097431"(mitotic spindle pole)|go:"GO:0098794"(postsynapse)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099140"(presynaptic actin cytoskeleton organization)|go:"GO:1904424"(regulation of GTP binding)|go:"GO:1905833"(negative regulation of microtubule nucleation)|rcsb pdb:2ESW|rcsb pdb:6JMT|reactome:R-MMU-182971|reactome:R-MMU-193648|reactome:R-MMU-3928664|mint:Q9ES28|interpro:IPR035789|interpro:IPR035899|interpro:IPR036028|interpro:IPR036872	afcs:17882(primary-reference)|afcs:30241(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Lgw2jqVCIb6BbZhrGCOtc4KOel010090	rogid:+Bie+UoaAI9/ldibUxAjNYc3sYs10090	intact-crc:2D6F4839246D7892|rigid:JuFQFdCq84KnnpVZrmO8Jc7n1MI	false	sufficient binding region:1-198	sufficient binding region:300-581	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CG48	uniprotkb:Q8BH43	intact:EBI-643436|uniprotkb:Q52KE9|uniprotkb:Q61076|uniprotkb:Q9CS17|uniprotkb:Q9CSD8|ensembl:ENSMUSP00000099979|ensembl:ENSMUSP00000113940	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:smc2_mouse(display_long)|uniprotkb:Chromosome-associated protein E(gene name synonym)|uniprotkb:XCAP-E homolog(gene name synonym)|uniprotkb:FGF-inducible protein 16(gene name synonym)|uniprotkb:Smc2(gene name)|psi-mi:Smc2(display_short)|uniprotkb:Cape(gene name synonym)|uniprotkb:Fin16(gene name synonym)|uniprotkb:Smc2l1(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651033	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032043.3|refseq:NP_001288341.1|ensembl:ENSMUSG00000028312(gene)|ensembl:ENSMUST00000102915(transcript)|ensembl:ENSMUST00000117280(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027120|interpro:IPR027417|interpro:IPR036277|mint:Q8CG48|rcsb pdb:3L51|reactome:R-MMU-2299718|reactome:R-MMU-2514853	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:14330(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:A8IwiTQIuTw7BA9PQ5ZTSmxFIQA10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:761041121DE02F07|rigid:QCygLMCh/xAiHLcCmBB0gpuF9fY	false	sufficient binding region:812-956	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CG48	uniprotkb:Q8BH43	intact:EBI-643436|uniprotkb:Q52KE9|uniprotkb:Q61076|uniprotkb:Q9CS17|uniprotkb:Q9CSD8|ensembl:ENSMUSP00000099979|ensembl:ENSMUSP00000113940	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:smc2_mouse(display_long)|uniprotkb:Chromosome-associated protein E(gene name synonym)|uniprotkb:XCAP-E homolog(gene name synonym)|uniprotkb:FGF-inducible protein 16(gene name synonym)|uniprotkb:Smc2(gene name)|psi-mi:Smc2(display_short)|uniprotkb:Cape(gene name synonym)|uniprotkb:Fin16(gene name synonym)|uniprotkb:Smc2l1(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651053	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032043.3|refseq:NP_001288341.1|ensembl:ENSMUSG00000028312(gene)|ensembl:ENSMUST00000102915(transcript)|ensembl:ENSMUST00000117280(transcript)|go:"GO:0000012"(single strand break repair)|go:"GO:0000228"(nuclear chromosome)|go:"GO:0000793"(condensed chromosome)|go:"GO:0000796"(condensin complex)|go:"GO:0003682"(chromatin binding)|go:"GO:0003697"(single-stranded DNA binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007076"(mitotic chromosome condensation)|go:"GO:0010032"(meiotic chromosome condensation)|go:"GO:0045132"(meiotic chromosome segregation)|go:"GO:0051301"(cell division)|go:"GO:0051383"(kinetochore organization)|interpro:IPR003395(RecF/RecN/SMC protein, N-terminal)|interpro:IPR010935(SMCs flexible hinge)|interpro:IPR024704|interpro:IPR027120|interpro:IPR027417|interpro:IPR036277|mint:Q8CG48|rcsb pdb:3L51|reactome:R-MMU-2299718|reactome:R-MMU-2514853	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:14330(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:A8IwiTQIuTw7BA9PQ5ZTSmxFIQA10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:7AA56146515762E8|rigid:QCygLMCh/xAiHLcCmBB0gpuF9fY	false	sufficient binding region:822-954	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60952	uniprotkb:Q8BH43	intact:EBI-643450|uniprotkb:E9QMB2|uniprotkb:Q2I8G3|uniprotkb:Q3UTR4|uniprotkb:Q6PFF6|uniprotkb:Q8BLC6|ensembl:ENSMUSP00000091988	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:cp250_mouse(display_long)|uniprotkb:Centrosomal protein 2(gene name synonym)|uniprotkb:Centrosomal Nek2-associated protein 1(gene name synonym)|uniprotkb:Intranuclear matrix protein(gene name synonym)|uniprotkb:Cep250(gene name)|psi-mi:Cep250(display_short)|uniprotkb:Inmp(gene name synonym)|uniprotkb:Cep2(gene name synonym)|uniprotkb:250 kDa centrosomal protein(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651063	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123471.1|refseq:NP_032409.3|refseq:NP_796191.2|go:"GO:0060271"(cilium assembly)|go:"GO:1905515"(non-motile cilium assembly)|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518|go:"GO:1904781"(positive regulation of protein localization to centrosome)|ensembl:ENSMUST00000094421(transcript)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008104"(protein localization)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031616"(spindle pole centrosome)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0036064"(ciliary basal body)|go:"GO:0048471"(perinuclear region of cytoplasm)|ensembl:ENSMUSG00000038241(gene)|go:"GO:0050908"(detection of light stimulus involved in visual perception)	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:14638(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LMBHPhbk4EoafGzfDA/pkR4gIYY10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:FE225E04B1A0B14A|rigid:3jERRCwy1d/FadADAJXQjbXy6e4	false	sufficient binding region:1-157	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z2L7	uniprotkb:Q8BH43	intact:EBI-643455|uniprotkb:Q5SYK6|uniprotkb:Q91W21|uniprotkb:Q9R262|ensembl:ENSMUSP00000060028	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:crlf3_mouse(display_long)|uniprotkb:Cytokine receptor-related factor 4(gene name synonym)|uniprotkb:Cytokine receptor-like molecule 9(gene name synonym)|uniprotkb:Crlf3(gene name)|psi-mi:Crlf3(display_short)|uniprotkb:Cytor4(gene name synonym)|uniprotkb:Creme9(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651073	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001264035.1|refseq:NP_061246.1|ensembl:ENSMUSG00000017561(gene)|ensembl:ENSMUST00000061283(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046427"(positive regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0051726"(regulation of cell cycle)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR036116|mint:Q9Z2L7|rcsb pdb:6RPX|rcsb pdb:6RPY|rcsb pdb:6RPZ	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:17942(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ySwqnyGz+tl+A89wTSOF4Ent/es10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:FBF91D0018FBBB7A|rigid:cK9xJXkU/kCap9vZS/o9u/CD5W8	false	sufficient binding region:1-170	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99LU0	uniprotkb:Q8BH43	intact:EBI-643463|uniprotkb:Q3UB77|uniprotkb:Q9CXR5|ensembl:ENSMUSP00000147285	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:ch1b1_mouse(display_long)|uniprotkb:Chromatin-modifying protein 1b-1(gene name synonym)|uniprotkb:Chmp1b1(gene name)|psi-mi:Chmp1b1(display_short)|uniprotkb:Chmp1b(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651083	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077152.1|go:"GO:0039702"(viral budding via host ESCRT complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0045184"(establishment of protein localization)|go:"GO:0045324"(late endosome to vacuole transport)|go:"GO:0051301"(cell division)|go:"GO:0032509"(endosome transport via multivesicular body sorting pathway)|go:"GO:0061952"(midbody abscission)|go:"GO:1901673"(regulation of mitotic spindle assembly)|interpro:IPR005024(Snf7)|go:"GO:0031902"(late endosome membrane)|go:"GO:0030496"(midbody)|go:"GO:0030117"(membrane coat)|ensembl:ENSMUSG00000109901(gene)|ensembl:ENSMUST00000210564(transcript)|go:"GO:0000815"(ESCRT III complex)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005829"(cytosol)|go:"GO:0006997"(nucleus organization)|go:"GO:0007080"(mitotic metaphase plate congression)|go:"GO:0010008"(endosome membrane)|go:"GO:0010824"(regulation of centrosome duplication)|go:"GO:0015031"(protein transport)|go:"GO:0019904"(protein domain specific binding)	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:24683(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:KCyg+KsmufDDXOZzSQ8vXZPPxZI10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:27D1ADB8CBB3C961|rigid:+S9esqNWoOaWFoDKr+2F+U3ukQg	false	sufficient binding region:24-199	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CHG3	uniprotkb:Q8BH43	intact:EBI-643470|uniprotkb:Q8BR44|uniprotkb:Q8R2Q5|uniprotkb:Q9CT45	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:gcc2_mouse(display_long)|uniprotkb:185 kDa Golgi coiled-coil protein(gene name synonym)|uniprotkb:Gcc2(gene name)|psi-mi:Gcc2(display_short)|uniprotkb:Kiaa0336(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651093	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000237(GRIP)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0016020"(membrane)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0070861"(regulation of protein exit from endoplasmic reticulum)|go:"GO:0071955"(recycling endosome to Golgi transport)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR032023|reactome:R-MMU-6811440	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34956(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jx7CHCvebJMJveYd27Mhq56/So010090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:BA09FB06FCE97AB5|rigid:Qh/wG84iqOi1poPkuEG4VvUxAcI	false	sufficient binding region:101-635	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CHG3	uniprotkb:Q8BH43	intact:EBI-643470|uniprotkb:Q8BR44|uniprotkb:Q8R2Q5|uniprotkb:Q9CT45	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:gcc2_mouse(display_long)|uniprotkb:185 kDa Golgi coiled-coil protein(gene name synonym)|uniprotkb:Gcc2(gene name)|psi-mi:Gcc2(display_short)|uniprotkb:Kiaa0336(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651113	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000237(GRIP)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0016020"(membrane)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0070861"(regulation of protein exit from endoplasmic reticulum)|go:"GO:0071955"(recycling endosome to Golgi transport)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR032023|reactome:R-MMU-6811440	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34956(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jx7CHCvebJMJveYd27Mhq56/So010090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:4F5E89F94B5852B1|rigid:Qh/wG84iqOi1poPkuEG4VvUxAcI	false	sufficient binding region:414-719	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CHG3	uniprotkb:Q8BH43	intact:EBI-643470|uniprotkb:Q8BR44|uniprotkb:Q8R2Q5|uniprotkb:Q9CT45	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:gcc2_mouse(display_long)|uniprotkb:185 kDa Golgi coiled-coil protein(gene name synonym)|uniprotkb:Gcc2(gene name)|psi-mi:Gcc2(display_short)|uniprotkb:Kiaa0336(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651123	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000237(GRIP)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0016020"(membrane)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0070861"(regulation of protein exit from endoplasmic reticulum)|go:"GO:0071955"(recycling endosome to Golgi transport)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR032023|reactome:R-MMU-6811440	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34956(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jx7CHCvebJMJveYd27Mhq56/So010090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:32F7DD76C688872F|rigid:Qh/wG84iqOi1poPkuEG4VvUxAcI	false	sufficient binding region:415-619	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CHG3	uniprotkb:Q8BH43	intact:EBI-643470|uniprotkb:Q8BR44|uniprotkb:Q8R2Q5|uniprotkb:Q9CT45	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:gcc2_mouse(display_long)|uniprotkb:185 kDa Golgi coiled-coil protein(gene name synonym)|uniprotkb:Gcc2(gene name)|psi-mi:Gcc2(display_short)|uniprotkb:Kiaa0336(gene name synonym)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651143	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000237(GRIP)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0016020"(membrane)|go:"GO:0031023"(microtubule organizing center organization)|go:"GO:0034067"(protein localization to Golgi apparatus)|go:"GO:0034453"(microtubule anchoring)|go:"GO:0034499"(late endosome to Golgi transport)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0042802"(identical protein binding)|go:"GO:0070861"(regulation of protein exit from endoplasmic reticulum)|go:"GO:0071955"(recycling endosome to Golgi transport)|go:"GO:0090161"(Golgi ribbon formation)|interpro:IPR032023|reactome:R-MMU-6811440	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34956(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jx7CHCvebJMJveYd27Mhq56/So010090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:365B07E7B50C404A|rigid:Qh/wG84iqOi1poPkuEG4VvUxAcI	false	sufficient binding region:720-759	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91VW5	uniprotkb:Q8BH43	intact:EBI-643481|uniprotkb:O70365|uniprotkb:Q8CGH6|ensembl:ENSMUSP00000081880	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:goga4_mouse(display_long)|uniprotkb:tGolgin-1(gene name synonym)|uniprotkb:Golga4(gene name)|psi-mi:Golga4(display_short)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651153	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000038708(gene)|ensembl:ENSMUST00000084820(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0031267"(small GTPase binding)|go:"GO:0043001"(Golgi to plasma membrane protein transport)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0048193"(Golgi vesicle transport)|go:"GO:0051020"(GTPase binding)|interpro:IPR000237(GRIP)|reactome:R-MMU-6811440|refseq:NP_061218.2	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34963(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:pK5clT3BtNvFt3T/mXdqAHaCmDA10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:EDADEF61E9AC6883|rigid:kVj9Uj3tA/ln2Drlo5E5zOeyvqE	false	sufficient binding region:167-404	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91VR8	uniprotkb:Q8BH43	intact:EBI-643491|uniprotkb:Q3TLB8|ensembl:ENSMUSP00000041644	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:brk1_mouse(display_long)|uniprotkb:Brk1(gene name)|psi-mi:Brk1(display_short)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651163	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000033940(gene)|ensembl:ENSMUST00000035725(transcript)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0005856"(cytoskeleton)|go:"GO:0007015"(actin filament organization)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0031209"(SCAR complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0048870"(cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR033378|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|refseq:NP_598698.1	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:22839(primary-reference)|afcs:34964(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:i3lwUUzuMjLnJpAMYYhOg4YmpVc10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:214883124B13BEBE|rigid:8nQY9ko8y5YI6cfmSnlnppNhwHc	false	sufficient binding region:4-75	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q920A7	uniprotkb:E9PZQ0	intact:EBI-643503|uniprotkb:Q3THK2|uniprotkb:Q6PGJ7|uniprotkb:Q9CZN2|ensembl:ENSMUSP00000001520	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:afg31_mouse(display_long)|uniprotkb:Afg3l1(gene name)|psi-mi:Afg3l1(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651192	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0034982"(mitochondrial protein processing)|ensembl:ENSMUSG00000031967(gene)|ensembl:ENSMUST00000001520(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005745"(m-AAA complex)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|interpro:IPR041569|go:"GO:0042407"(cristae formation)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR027417|interpro:IPR037219|refseq:NP_473411.2|refseq:XP_011246578.1	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34658(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SSwXdNF47dkqrpKBMuQHK2DgMCk10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:260C8A90DE7751AE|rigid:w1OSXzA4QGaqwwVwT2Wjl7KYIiM	false	sufficient binding region:127-274	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q920A7	uniprotkb:E9PZQ0	intact:EBI-643503|uniprotkb:Q3THK2|uniprotkb:Q6PGJ7|uniprotkb:Q9CZN2|ensembl:ENSMUSP00000001520	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:afg31_mouse(display_long)|uniprotkb:Afg3l1(gene name)|psi-mi:Afg3l1(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651202	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0034982"(mitochondrial protein processing)|ensembl:ENSMUSG00000031967(gene)|ensembl:ENSMUST00000001520(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005745"(m-AAA complex)|go:"GO:0004176"(ATP-dependent peptidase activity)|go:"GO:0007005"(mitochondrion organization)|go:"GO:0004222"(metalloendopeptidase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0008053"(mitochondrial fusion)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016485"(protein processing)|interpro:IPR041569|go:"GO:0042407"(cristae formation)|go:"GO:0065003"(protein-containing complex assembly)|interpro:IPR000642(Peptidase M41)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR003959(AAA ATPase, core)|interpro:IPR003960(AAA ATPase, conserved site)|interpro:IPR005936(Peptidase M41, FtsH)|interpro:IPR011546(Peptidase M41, FtsH extracellular)|interpro:IPR027417|interpro:IPR037219|refseq:NP_473411.2|refseq:XP_011246578.1	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34658(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SSwXdNF47dkqrpKBMuQHK2DgMCk10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:ECD2A1A26EA46F21|rigid:w1OSXzA4QGaqwwVwT2Wjl7KYIiM	false	sufficient binding region:127-294	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R4X3	uniprotkb:P25911	intact:EBI-643560|uniprotkb:Q8K373|uniprotkb:Q8R302|uniprotkb:Q9CS80|uniprotkb:B6ICZ5|uniprotkb:Q3TKT7|uniprotkb:Q7TT14|ensembl:ENSMUSP00000050461|ensembl:ENSMUSP00000105233	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:rbm12_mouse(display_long)|uniprotkb:RNA-binding motif protein 12(gene name synonym)|uniprotkb:SH3/WW domain anchor protein in the nucleus(gene name synonym)|uniprotkb:Rbm12(gene name)|psi-mi:Rbm12(display_short)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651232	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083673.3|refseq:NP_733486.2|ensembl:ENSMUSG00000089824(gene)|ensembl:ENSMUST00000109604(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034591|interpro:IPR034594|interpro:IPR034854|interpro:IPR034855|interpro:IPR034856|interpro:IPR035979|rcsb pdb:2CQP|ensembl:ENSMUST00000059647(transcript)	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	afcs:7137(primary-reference)|afcs:34969(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:R/okh5JGU0qFpNksZevcR1MUN1w10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:847D0169B65DF86B|rigid:NEK6gtaQNwTyrTJVmAl8PUcgsBE	false	sufficient binding region:7-366	sufficient binding region:60-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P60766-2	uniprotkb:O88643	intact:EBI-287404|uniprotkb:P21181-4|ensembl:ENSMUSP00000054634	intact:EBI-457240	psi-mi:p60766-2(display_long)|uniprotkb:Cdc42(gene name)|psi-mi:Cdc42(display_short)|uniprotkb:G25K GTP-binding protein(gene name synonym)|uniprotkb:Placental(isoform synonym)	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651254	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-81763(cdc42_mouse)|ensembl:ENSMUSG00000006699(gene)|ensembl:ENSMUST00000051477(transcript)	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	afcs:16524(primary-reference)|afcs:15804(secondary-ac)	isoform-comment:Has not been isolated in bovine so far	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jiYEHWm+9LQyVj0eUGZOBGaajyU10090	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	intact-crc:53E75DBA72B222FE|rigid:8SLvWv2a/VFyNy05uzjvnAd76Qo	false	sufficient binding region:1-191	sufficient binding region:1-121	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-682373	uniprotkb:P35991	-	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	psi-mi:igh6-afcs_mouse(display_short)|psi-mi:EBI-682373(display_long)	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688224	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	afcs:34968(primary-reference)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	afcs:34968(secondary-ac)|afcs:17216(primary-reference)|afcs:34968(primary-reference)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"AfCS Y2H 34968 protein. Sequence deduced from cross-reference: protein GI:2995714."|comment:"similar to mouse Igh-6 protein (90%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:DRY2AzmmGQE+R3kH3Oa7VLK8TmQ10090	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	intact-crc:8D0D7282C0CCF5A9|rigid:xL5gmlDe3NKhJbEwbHdbjD4z02w	false	sufficient binding region:181-299	sufficient binding region:210-280	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-682042	uniprotkb:Q8BH43	-	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:cep2-afcs_mouse(display_short)|psi-mi:EBI-682042(display_long)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688235	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	afcs:14638(primary-reference)	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:14638(secondary-ac)|afcs:14638(primary-reference)|afcs:22839(primary-reference)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"AfCS Y2H protein 14638. Sequence deduced from the cross-reference: Protein GI: 6680455"|comment:"similar to mouse Centrosomal protein 2 (Intranuclear matrix protein) fragment"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LLl5kfffWIF72o39t+xD6ZsCP2Q10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:54F4C05BEA7B294E|rigid:8oBIRfAbD2T2xeWsDcpdOMSzrvs	false	sufficient binding region:1-158	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BH43	intact:EBI-682042	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	-	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:cep2-afcs_mouse(display_short)|psi-mi:EBI-682042(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688248	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:14638(primary-reference)	afcs:14638(secondary-ac)|afcs:14638(primary-reference)|afcs:22839(primary-reference)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"AfCS Y2H protein 14638. Sequence deduced from the cross-reference: Protein GI: 6680455"|comment:"similar to mouse Centrosomal protein 2 (Intranuclear matrix protein) fragment"	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	rogid:LLl5kfffWIF72o39t+xD6ZsCP2Q10090	intact-crc:C196D88BE0E88058|rigid:8oBIRfAbD2T2xeWsDcpdOMSzrvs	false	sufficient binding region:1-170	sufficient binding region:1-161	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-682042	uniprotkb:Q8BH43	-	intact:EBI-643162|ensembl:ENSMUSP00000081263|ensembl:ENSMUSP00000101532	psi-mi:cep2-afcs_mouse(display_short)|psi-mi:EBI-682042(display_long)	psi-mi:wasf2_mouse(display_long)|uniprotkb:Protein WAVE-2(gene name synonym)|uniprotkb:Wave2(gene name synonym)|uniprotkb:Wasf2(gene name)|psi-mi:Wasf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688259	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	afcs:14638(primary-reference)	refseq:NP_700472.1|refseq:XP_006538911.1|refseq:XP_006538912.1|refseq:XP_006538913.1|ensembl:ENSMUSG00000028868(gene)|ensembl:ENSMUST00000084241(transcript)|ensembl:ENSMUST00000105912(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001667"(ameboidal-type cell migration)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005769"(early endosome)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006897"(endocytosis)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031209"(SCAR complex)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0045202"(synapse)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071933"(Arp2/3 complex binding)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098974"(postsynaptic actin cytoskeleton organization)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR028288|mint:Q8BH43|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29535N	afcs:14638(secondary-ac)|afcs:14638(primary-reference)|afcs:22839(primary-reference)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"AfCS Y2H protein 14638. Sequence deduced from the cross-reference: Protein GI: 6680455"|comment:"similar to mouse Centrosomal protein 2 (Intranuclear matrix protein) fragment"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LLl5kfffWIF72o39t+xD6ZsCP2Q10090	rogid:uXkOyyt8x6/M/EU/uhIp8/BAc9w10090	intact-crc:C217DD851221E5FE|rigid:8oBIRfAbD2T2xeWsDcpdOMSzrvs	false	sufficient binding region:36-159	sufficient binding region:1-170	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37889-1	uniprotkb:P25118	intact:EBI-645953|ensembl:ENSMUSP00000048334	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654924	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:1F77C0A861555F82|rigid:ycHuOCAp791lpJWpmLMAtiP/7/k	false	sufficient binding region:187-373	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WVK0	uniprotkb:P25118	intact:EBI-645964|uniprotkb:Q9D8Z8|uniprotkb:Q9D940|uniprotkb:B2KFL8|uniprotkb:Q3U7X6|ensembl:ENSMUSP00000030865	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:atrap_mouse(display_long)|uniprotkb:AT1 receptor-associated protein(gene name synonym)|uniprotkb:Agtrap(gene name)|psi-mi:Agtrap(display_short)|uniprotkb:Atrap(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654935	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033772.2|ensembl:ENSMUSG00000029007(gene)|ensembl:ENSMUST00000030865(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0001666"(response to hypoxia)|go:"GO:0004945"(angiotensin type II receptor activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR009436(Angiotensin II, type I receptor-associated)	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:15648(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:lsUO0uebiZ/LA9e3ug/HJOlpYSI10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:F151294082DD4F34|rigid:VhxaJeXJnqvIU+8SVw4pGyNkPPo	false	sufficient binding region:1-68	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61491	uniprotkb:P25118	intact:EBI-642944	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:q61491_mouse(display_long)|uniprotkb:Zfp97(gene name)|psi-mi:Zfp97(display_short)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654945	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR036051|interpro:IPR036236	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:16966(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:9aawDNJKpT/07zRBL7d0EaY5T9k10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:1A405481AF51380B|rigid:yljjlxUTlZDstdYRFvMcE/SO0L8	false	sufficient binding region:10-546	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WV55	uniprotkb:P25118	intact:EBI-645974|uniprotkb:Q9QY77|uniprotkb:Q3TJM1|ensembl:ENSMUSP00000024897	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:vapa_mouse(display_long)|uniprotkb:33 kDa VAMP-associated protein(gene name synonym)|uniprotkb:Vapa(gene name)|psi-mi:Vapa(display_short)|uniprotkb:Vap33(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654955	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038961.2|ensembl:ENSMUSG00000024091(gene)|ensembl:ENSMUST00000024897(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0008017"(microtubule binding)|go:"GO:0008219"(cell death)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0031175"(neuron projection development)|go:"GO:0031965"(nuclear membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033149"(FFAT motif binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044791"(obsolete positive regulation by host of viral release from host cell)|go:"GO:0044828"(negative regulation by host of viral genome replication)|go:"GO:0044829"(positive regulation by host of viral genome replication)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0070972"(protein localization to endoplasmic reticulum)|go:"GO:0090114"(COPII-coated vesicle budding)|interpro:IPR000535(Major sperm protein)|interpro:IPR008962(PapD-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR016763(Vesicle-associated membrane protein)|mint:Q9WV55|rcsb pdb:2CRI|reactome:R-MMU-1660661|reactome:R-MMU-6798695|reactome:R-MMU-9609523	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:17557(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LQV6uN7oD/EpHQvexl/pGkG6bmE10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:A9355D815712BCCE|rigid:Q6KxVq3HZmZs9QTnlrXIxqKF6ak	false	sufficient binding region:16-202	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61165	uniprotkb:P25118	intact:EBI-645984|ensembl:ENSMUSP00000030669	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:sl9a1_mouse(display_long)|uniprotkb:"Na(+)/H(+) exchanger 1"(gene name synonym)|uniprotkb:Solute carrier family 9 member 1(gene name synonym)|uniprotkb:Slc9a1(gene name)|psi-mi:Slc9a1(display_short)|uniprotkb:Nhe1(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654965	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058677.1|ensembl:ENSMUSG00000028854(gene)|ensembl:ENSMUST00000030669(transcript)|go:"GO:0002026"(regulation of the force of heart contraction)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0035794"(positive regulation of mitochondrial membrane permeability)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0036376"(sodium ion export across plasma membrane)|go:"GO:0042383"(sarcolemma)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045121"(membrane raft)|go:"GO:0045760"(positive regulation of action potential)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051259"(protein complex oligomerization)|go:"GO:0051453"(regulation of intracellular pH)|go:"GO:0051930"(regulation of sensory perception of pain)|go:"GO:0055007"(cardiac muscle cell differentiation)|go:"GO:0070417"(cellular response to cold)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0070997"(neuron death)|go:"GO:0071236"(cellular response to antibiotic)|go:"GO:0071257"(cellular response to electrical stimulus)|go:"GO:0030346"(protein phosphatase 2B binding)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071468"(cellular response to acidic pH)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006814"(sodium ion transport)|go:"GO:0006883"(cellular sodium ion homeostasis)|go:"GO:0006885"(regulation of pH)|go:"GO:0009986"(cell surface)|go:"GO:0010447"(response to acidic pH)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0014704"(intercalated disc)|go:"GO:0015385"("sodium:proton antiporter activity")|go:"GO:0015386"("potassium:proton antiporter activity")|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030315"(T-tubule)|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0086003"(cardiac muscle cell contraction)|go:"GO:0086092"(regulation of the force of heart contraction by cardiac conduction)|go:"GO:0090533"(cation-transporting ATPase complex)|go:"GO:0098719"(sodium ion import across plasma membrane)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:1902533"(positive regulation of intracellular signal transduction)|go:"GO:1902600"(proton transmembrane transport)|go:"GO:1903281"("positive regulation of calcium:sodium antiporter activity")|interpro:IPR001970("Na+/H+ exchanger isoform 1 (NHE1)")|interpro:IPR004709(Sodium/hydrogen exchanger subfamily)|interpro:IPR006153(Sodium/hydrogen exchanger)|interpro:IPR018422|go:"GO:0071805"(potassium ion transmembrane transport)|interpro:IPR032103|reactome:R-MMU-2160916|reactome:R-MMU-425986	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:17854(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:wlBvjW/vuTmfN2WCp4+eh3FcJvo10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:22D292ABA8022D2B|rigid:e3b8O4D5KYTrpV3Finak7SifA5o	false	sufficient binding region:110-531	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QX47-2	uniprotkb:P25118	intact:EBI-643055|ensembl:ENSMUSP00000109670	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:q9qx47-2(display_long)|uniprotkb:Nrebp(gene name synonym)|uniprotkb:Negative regulatory element-binding protein(gene name synonym)|uniprotkb:Son(gene name)|psi-mi:Son(display_short)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654975	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-643037(son_mouse)|ensembl:ENSMUSG00000022961(gene)|ensembl:ENSMUST00000114036(transcript)	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:18406(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JyhEp99sJRLALu/9cXM5hv1zliw10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:831C18EA773758CD|rigid:s3/fUsvxHct0EstjK4xee8o4zHU	false	sufficient binding region:1328-1465	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K443	uniprotkb:Q9CZW5	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654996	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	intact-crc:BAC4016BA7C65EEA|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:1-158	sufficient binding region:282-611	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655046	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:23009(secondary-ac)|afcs:35827(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:8F6DC51B19EF78A2|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:350-611	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655076	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:29AA44C5BA058DD7|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:380-543	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZW5	uniprotkb:Q8K443	intact:EBI-642469|uniprotkb:Q8BNI6|ensembl:ENSMUSP00000129186	intact:EBI-645999|ensembl:ENSMUSP00000107572|ensembl:ENSMUSP00000058813	psi-mi:tom70_mouse(display_long)|uniprotkb:Tomm70(gene name)|psi-mi:Tomm70(display_short)|uniprotkb:D16Wsu109e(gene name synonym)|uniprotkb:Mitochondrial precursor proteins import receptor(gene name synonym)|uniprotkb:Tomm70a(gene name synonym)|uniprotkb:Translocase of outer membrane 70 kDa subunit(gene name synonym)|uniprotkb:Translocase of outer mitochondrial membrane protein 70(gene name synonym)	psi-mi:rgs13_mouse(display_long)|uniprotkb:Rgs13(gene name)|psi-mi:Rgs13(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655096	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_613065.2|ensembl:ENSMUSG00000022752(gene)|ensembl:ENSMUST00000166897(transcript)|go:"GO:0002218"(activation of innate immune response)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0005739"(mitochondrion)|go:"GO:0005742"(mitochondrial outer membrane translocase complex)|go:"GO:0006626"(protein targeting to mitochondrion)|go:"GO:0031307"(integral component of mitochondrial outer membrane)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0098586"(cellular response to virus)|go:"GO:1904591"(positive regulation of protein import)|interpro:IPR001440(Tetratricopeptide TPR-1)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR019734|mint:Q9CZW5|reactome:R-MMU-168928|reactome:R-MMU-5205685|reactome:R-MMU-5689880	refseq:NP_694811.1|refseq:XP_006529676.1|ensembl:ENSMUST00000052375(transcript)|ensembl:ENSMUST00000111941(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0045744"(negative regulation of G protein-coupled receptor signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR024066|interpro:IPR034954|interpro:IPR036305|reactome:R-MMU-416476|reactome:R-MMU-418594|ensembl:ENSMUSG00000051079(gene)	afcs:35827(primary-reference)|afcs:23009(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:RmCLZz8Lvz+5FRry2GydOLFAIjs10090	rogid:ddlrKh7Cg8pmEElQO57kcPU4NAc10090	intact-crc:FA1EEF8CC016A7C2|rigid:tHaLVMXGeHUMmgvK61yEtXUiOSI	false	sufficient binding region:400-611	sufficient binding region:1-158	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q31125	uniprotkb:P25118	intact:EBI-644519|uniprotkb:Q3TVU6|uniprotkb:Q9Z1W1|ensembl:ENSMUSP00000025186|ensembl:ENSMUSP00000130102	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:s39a7_mouse(display_long)|uniprotkb:Solute carrier family 39 member 7(gene name synonym)|uniprotkb:Histidine-rich membrane protein Ke4(gene name synonym)|uniprotkb:Slc39a7(gene name)|psi-mi:Slc39a7(display_short)|uniprotkb:H2-Ke4(gene name synonym)|uniprotkb:Hke4(gene name synonym)|uniprotkb:Zrt-, Irt-like protein 7(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655106	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001071177.1|refseq:NP_032228.2|ensembl:ENSMUSG00000024327(gene)|ensembl:ENSMUST00000025186(transcript)|ensembl:ENSMUST00000169397(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR003689(Zinc/iron permease)|reactome:R-MMU-442380	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:23552(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BVLmJQnAanBeKDcJBsaDieohUTk10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:8FE0B35A2CBBC6A5|rigid:m3j4aYx1HdmpEEN4tqQ6w/Vuz9U	false	sufficient binding region:19-146	sufficient binding region:1-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q31125	uniprotkb:P25118	intact:EBI-644519|uniprotkb:Q3TVU6|uniprotkb:Q9Z1W1|ensembl:ENSMUSP00000025186|ensembl:ENSMUSP00000130102	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:s39a7_mouse(display_long)|uniprotkb:Solute carrier family 39 member 7(gene name synonym)|uniprotkb:Histidine-rich membrane protein Ke4(gene name synonym)|uniprotkb:Slc39a7(gene name)|psi-mi:Slc39a7(display_short)|uniprotkb:H2-Ke4(gene name synonym)|uniprotkb:Hke4(gene name synonym)|uniprotkb:Zrt-, Irt-like protein 7(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655117	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001071177.1|refseq:NP_032228.2|ensembl:ENSMUSG00000024327(gene)|ensembl:ENSMUST00000025186(transcript)|ensembl:ENSMUST00000169397(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR003689(Zinc/iron permease)|reactome:R-MMU-442380	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:23552(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BVLmJQnAanBeKDcJBsaDieohUTk10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:8F08CFE77E90961C|rigid:m3j4aYx1HdmpEEN4tqQ6w/Vuz9U	false	sufficient binding region:29-254	sufficient binding region:1-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q31125	uniprotkb:P25118	intact:EBI-644519|uniprotkb:Q3TVU6|uniprotkb:Q9Z1W1|ensembl:ENSMUSP00000025186|ensembl:ENSMUSP00000130102	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:s39a7_mouse(display_long)|uniprotkb:Solute carrier family 39 member 7(gene name synonym)|uniprotkb:Histidine-rich membrane protein Ke4(gene name synonym)|uniprotkb:Slc39a7(gene name)|psi-mi:Slc39a7(display_short)|uniprotkb:H2-Ke4(gene name synonym)|uniprotkb:Hke4(gene name synonym)|uniprotkb:Zrt-, Irt-like protein 7(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655127	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001071177.1|refseq:NP_032228.2|ensembl:ENSMUSG00000024327(gene)|ensembl:ENSMUST00000025186(transcript)|ensembl:ENSMUST00000169397(transcript)|go:"GO:0005385"(zinc ion transmembrane transporter activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0016021"(integral component of membrane)|go:"GO:0071577"(zinc ion transmembrane transport)|interpro:IPR003689(Zinc/iron permease)|reactome:R-MMU-442380	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:23552(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BVLmJQnAanBeKDcJBsaDieohUTk10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:97E8FDCEEF7A6343|rigid:m3j4aYx1HdmpEEN4tqQ6w/Vuz9U	false	sufficient binding region:29-335	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CQS8	uniprotkb:P25118	intact:EBI-646010|ensembl:ENSMUSP00000067681	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:sc61b_mouse(display_long)|uniprotkb:Sec61b(gene name)|psi-mi:Sec61b(display_short)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655137	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077133.1|ensembl:ENSMUSG00000053317(gene)|ensembl:ENSMUST00000065678(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005784"(Sec61 translocon complex)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0006616"(SRP-dependent cotranslational protein targeting to membrane, translocation)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030970"(retrograde protein transport, ER to cytosol)|go:"GO:0031204"(posttranslational protein targeting to membrane, translocation)|go:"GO:0043022"(ribosome binding)|go:"GO:0044322"(endoplasmic reticulum quality control compartment)|go:"GO:0048408"(epidermal growth factor binding)|interpro:IPR016482(Preprotein translocase Sec, Sec61-beta subunit, eukarya)|interpro:IPR030671	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:24673(secondary-ac)	-	-	caution:The prey construct contains 2 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:oYv4LR4IHW0y8CFM1qhPln1/NB410090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:07C918047E4E5664|rigid:OvXem5a/d2BZE6gO12JVRk34TbU	false	sufficient binding region:2-96	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99ML9	uniprotkb:P25118	intact:EBI-646015|uniprotkb:Q8C881|uniprotkb:Q8CBC0|uniprotkb:Q3UVL7|uniprotkb:Q6NSW2|uniprotkb:Q7TMR3|ensembl:ENSMUSP00000034739|ensembl:ENSMUSP00000109225	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:rn111_mouse(display_long)|uniprotkb:RING finger protein 111(gene name synonym)|uniprotkb:Rnf111(gene name)|psi-mi:Rnf111(display_short)|uniprotkb:RING-type E3 ubiquitin transferase Arkadia(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655147	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_291082.1|refseq:XP_006511649.1|ensembl:ENSMUSG00000032217(gene)|ensembl:ENSMUST00000034739(transcript)|ensembl:ENSMUST00000113595(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR029306|reactome:R-MMU-2173796|reactome:R-MMU-5696395|reactome:R-MMU-983168|go:"GO:0004842"(ubiquitin-protein transferase activity)	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:33527(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1jqb63Pi0keEW6WZyK0W4+A1PIo10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:1EE47E1FEE836944|rigid:Gdgno8eOKxAbvsyfX+aV02ex0NY	false	sufficient binding region:285-521	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99ML9	uniprotkb:P25118	intact:EBI-646015|uniprotkb:Q8C881|uniprotkb:Q8CBC0|uniprotkb:Q3UVL7|uniprotkb:Q6NSW2|uniprotkb:Q7TMR3|ensembl:ENSMUSP00000034739|ensembl:ENSMUSP00000109225	intact:EBI-518014|ensembl:ENSMUSP00000032491	psi-mi:rn111_mouse(display_long)|uniprotkb:RING finger protein 111(gene name synonym)|uniprotkb:Rnf111(gene name)|psi-mi:Rnf111(display_short)|uniprotkb:RING-type E3 ubiquitin transferase Arkadia(gene name synonym)	psi-mi:tnr1a_mouse(display_long)|uniprotkb:p60(gene name synonym)|uniprotkb:Tumor necrosis factor receptor 1(gene name synonym)|uniprotkb:Tumor necrosis factor receptor type I(gene name synonym)|uniprotkb:p55(gene name synonym)|uniprotkb:Tnfrsf1a(gene name)|psi-mi:Tnfrsf1a(display_short)|uniprotkb:Tnfr1(gene name synonym)|uniprotkb:Tnfr-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655157	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_291082.1|refseq:XP_006511649.1|ensembl:ENSMUSG00000032217(gene)|ensembl:ENSMUST00000034739(transcript)|ensembl:ENSMUST00000113595(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006281"(DNA repair)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0007389"(pattern specification process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0030511"(positive regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0030579"(ubiquitin-dependent SMAD protein catabolic process)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032184"(SUMO polymer binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046332"(SMAD binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0061630"(ubiquitin protein ligase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR029306|reactome:R-MMU-2173796|reactome:R-MMU-5696395|reactome:R-MMU-983168|go:"GO:0004842"(ubiquitin-protein transferase activity)	refseq:NP_035739.2|dip:DIP-34532N|ensembl:ENSMUSG00000030341(gene)|ensembl:ENSMUST00000032491(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0002020"(protease binding)|go:"GO:0003176"(aortic valve development)|go:"GO:0003177"(pulmonary valve development)|go:"GO:0003332"(negative regulation of extracellular matrix constituent secretion)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006693"(prostaglandin metabolic process)|go:"GO:0006952"(defense response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0008630"(intrinsic apoptotic signaling pathway in response to DNA damage)|go:"GO:0009986"(cell surface)|go:"GO:0010614"(negative regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030424"(axon)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1902339"(positive regulation of apoptotic process involved in morphogenesis)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|interpro:IPR000488(Death)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR011029(DEATH-like)|interpro:IPR020419|interpro:IPR033993|interpro:IPR033994|mint:P25118|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|reactome:R-MMU-5669034|reactome:R-MMU-75893|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043235"(receptor complex)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)	afcs:6783(primary-reference)|afcs:33527(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1jqb63Pi0keEW6WZyK0W4+A1PIo10090	rogid:7ovm7yoJ2VOpT/hdIuGCOyqEhzM10090	intact-crc:8657A01E74A0F280|rigid:Gdgno8eOKxAbvsyfX+aV02ex0NY	false	sufficient binding region:312-696	sufficient binding region:80-220	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655167	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:9F099134E945344B|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:282-727	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655179	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:53636D4E45C44ECF|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:302-727	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655189	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:411EBE17E533EDF1|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:324-727	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655230	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:833698D512B8B29C|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:372-727	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655250	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:E957D89554F3D465|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:524-654	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BPU7-1	uniprotkb:Q8BUR4	intact:EBI-644162|ensembl:ENSMUSP00000072334	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:q8bpu7-1(display_long)|uniprotkb:Elmo1(gene name)|psi-mi:Elmo1(display_short)|uniprotkb:Protein ced-12 homolog(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655280	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-644143(elmo1_mouse)|ensembl:ENSMUSG00000041112(gene)|ensembl:ENSMUST00000072519(transcript)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:35253(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8fuu+TVFIrNgiHEaYqWg3e0LZ8010090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:1D4E6B049716C153|rigid:AOfZEjJXw5bX6RNgdfYYtwZzZ18	false	sufficient binding region:535-689	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BYZ7	uniprotkb:Q8BUR4	intact:EBI-646035|uniprotkb:Q6PDE4|ensembl:ENSMUSP00000105000	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:elmo3_mouse(display_long)|uniprotkb:Elmo3(gene name)|psi-mi:Elmo3(display_short)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655300	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766348.3|ensembl:ENSMUSG00000014791(gene)|ensembl:ENSMUST00000109375(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0048870"(cell motility)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030719	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:40199(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:J1VuWFosyLfFwcOdpjtSFgGvRHM10090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:11CE73CAC17315F7|rigid:UwROjZKhH/ywr/aSgpUy+zghg3I	false	sufficient binding region:?-?	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BYZ7	uniprotkb:Q8BUR4	intact:EBI-646035|uniprotkb:Q6PDE4|ensembl:ENSMUSP00000105000	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:elmo3_mouse(display_long)|uniprotkb:Elmo3(gene name)|psi-mi:Elmo3(display_short)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655310	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766348.3|ensembl:ENSMUSG00000014791(gene)|ensembl:ENSMUST00000109375(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0048870"(cell motility)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030719	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:40199(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:J1VuWFosyLfFwcOdpjtSFgGvRHM10090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:10628030B694C85E|rigid:UwROjZKhH/ywr/aSgpUy+zghg3I	false	sufficient binding region:475-649	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BYZ7	uniprotkb:Q8BUR4	intact:EBI-646035|uniprotkb:Q6PDE4|ensembl:ENSMUSP00000105000	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:elmo3_mouse(display_long)|uniprotkb:Elmo3(gene name)|psi-mi:Elmo3(display_short)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655320	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_766348.3|ensembl:ENSMUSG00000014791(gene)|ensembl:ENSMUST00000109375(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0048870"(cell motility)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030719	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:40199(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:J1VuWFosyLfFwcOdpjtSFgGvRHM10090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:8C547297639C96F7|rigid:UwROjZKhH/ywr/aSgpUy+zghg3I	false	sufficient binding region:479-633	sufficient binding region:1-250	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BUR4	uniprotkb:Q8R105	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	intact:EBI-646055|uniprotkb:Q3TY76|ensembl:ENSMUSP00000085264|ensembl:ENSMUSP00000158500	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:vp37c_mouse(display_long)|uniprotkb:Vps37c(gene name)|psi-mi:Vps37c(display_short)|uniprotkb:ESCRT-I complex subunit VPS37C(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655370	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	refseq:NP_852068.1|refseq:XP_006526635.1|refseq:XP_006526636.1|refseq:XP_006526637.1|refseq:XP_006526638.1|refseq:XP_011245412.1|go:"GO:0000813"(ESCRT I complex)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006623"(protein targeting to vacuole)|go:"GO:0031902"(late endosome membrane)|go:"GO:0043162"(ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0048306"(calcium-dependent protein binding)|interpro:IPR009851(Modifier of rudimentary, Modr)|interpro:IPR029012|interpro:IPR037202|reactome:R-MMU-917729|ensembl:ENSMUSG00000048832(gene)|ensembl:ENSMUST00000087951(transcript)|ensembl:ENSMUST00000235927(transcript)	afcs:35825(primary-reference)|afcs:54997(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	rogid:gLlCm+QPWgBZfX75QYo+B80eycY10090	intact-crc:4070BCA8BB9710DF|rigid:B/Ds0FUE7vSO8oHwydE5vMFhPZE	false	sufficient binding region:1-181	sufficient binding region:2-312	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BHL5	uniprotkb:Q8BUR4	intact:EBI-646085|uniprotkb:A2A5A6|uniprotkb:Q8BHL9|uniprotkb:Q8BQG1|uniprotkb:Q8CBM8|uniprotkb:Q8CC50|uniprotkb:Q8CH98|uniprotkb:Q91ZU2|uniprotkb:Q9CT75|uniprotkb:Q5GMG3|ensembl:ENSMUSP00000073691	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:elmo2_mouse(display_long)|uniprotkb:Elmo2(gene name)|psi-mi:Elmo2(display_short)|uniprotkb:Kiaa1834(gene name synonym)|uniprotkb:Protein ced-12 homolog A(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655422	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_525026.2|refseq:NP_997589.1|refseq:NP_001289681.1|refseq:NP_001289683.1|refseq:XP_011237586.1|refseq:XP_011237587.1|refseq:XP_011237588.1|refseq:XP_017170976.1|ensembl:ENSMUSG00000017670(gene)|ensembl:ENSMUST00000074046(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0048870"(cell motility)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030713|rcsb pdb:6UKA|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013408	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:40180(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:oNd1VPvn67exOyQdUCZ6riSI01U10090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:52FF077855ED46DE|rigid:eGIF4T4iKKe2Qb6stGsESb6T80A	false	sufficient binding region:481-730	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BHL5	uniprotkb:Q8BUR4	intact:EBI-646085|uniprotkb:A2A5A6|uniprotkb:Q8BHL9|uniprotkb:Q8BQG1|uniprotkb:Q8CBM8|uniprotkb:Q8CC50|uniprotkb:Q8CH98|uniprotkb:Q91ZU2|uniprotkb:Q9CT75|uniprotkb:Q5GMG3|ensembl:ENSMUSP00000073691	intact:EBI-646023|uniprotkb:Q6PD14|uniprotkb:Q8BVC9|uniprotkb:Q91Z55|uniprotkb:Q922V1|uniprotkb:Q3URT8|uniprotkb:Q3UY80|uniprotkb:Q4QQL8|ensembl:ENSMUSP00000081531	psi-mi:elmo2_mouse(display_long)|uniprotkb:Elmo2(gene name)|psi-mi:Elmo2(display_short)|uniprotkb:Kiaa1834(gene name synonym)|uniprotkb:Protein ced-12 homolog A(gene name synonym)	psi-mi:dock1_mouse(display_long)|uniprotkb:180 kDa protein downstream of CRK(gene name synonym)|uniprotkb:Dock1(gene name)|psi-mi:Dock1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655432	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_525026.2|refseq:NP_997589.1|refseq:NP_001289681.1|refseq:NP_001289683.1|refseq:XP_011237586.1|refseq:XP_011237587.1|refseq:XP_011237588.1|refseq:XP_017170976.1|ensembl:ENSMUSG00000017670(gene)|ensembl:ENSMUST00000074046(transcript)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007015"(actin filament organization)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0048870"(cell motility)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0098609"(cell-cell adhesion)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006816(Engulfment and cell motility, ELM)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR024574|interpro:IPR030713|rcsb pdb:6UKA|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013408	refseq:NP_001028592.1|ensembl:ENSMUSG00000058325(gene)|ensembl:ENSMUST00000084488(transcript)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006909"(phagocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010634"(positive regulation of epithelial cell migration)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016607"(nuclear speck)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0032045"(guanyl-nucleotide exchange factor complex)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001452(Src homology-3)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026791|interpro:IPR027007|interpro:IPR027357|interpro:IPR032376|interpro:IPR035892|interpro:IPR036028|interpro:IPR042455|interpro:IPR043161|interpro:IPR043162|mint:Q8BUR4|rcsb pdb:2M0Y|reactome:R-MMU-2029482|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-8849471|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|interpro:IPR010703(Dedicator of cytokinesis)|reactome:R-MMU-983231	afcs:35825(primary-reference)|afcs:40180(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:oNd1VPvn67exOyQdUCZ6riSI01U10090	rogid:S4GIwsM9C6JjeEiQiovvf4QZJGI10090	intact-crc:C16A6DDFEA2BF454|rigid:eGIF4T4iKKe2Qb6stGsESb6T80A	false	sufficient binding region:509-680	sufficient binding region:1-181	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61026	intact:EBI-688030	intact:EBI-688662|uniprotkb:E9QMH9|uniprotkb:O09001|uniprotkb:P97759|ensembl:ENSMUSP00000006037	afcs:35828	psi-mi:ncoa2_mouse(display_long)|uniprotkb:Transcriptional intermediary factor 2(gene name synonym)|uniprotkb:Glucocorticoid receptor-interacting protein 1(gene name synonym)|uniprotkb:Ncoa2(gene name)|psi-mi:Ncoa2(display_short)|uniprotkb:Grip1(gene name synonym)|uniprotkb:Tif2(gene name synonym)|uniprotkb:Src2(gene name synonym)|uniprotkb:Steroid receptor coactivator 2(gene name synonym)	psi-mi:ep300_mouse_protein(display_short)|psi-mi:EBI-688030(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688685	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032704.2|refseq:XP_006495528.1|dip:DIP-5979N|ensembl:ENSMUSG00000005886(gene)|ensembl:ENSMUST00000006037(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001162"(RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005874"(microtubule)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007623"(circadian rhythm)|go:"GO:0008134"(transcription factor binding)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010906"(regulation of glucose metabolic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016604"(nuclear body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0017162"(aryl hydrocarbon receptor binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0030425"(dendrite)|go:"GO:0032570"(response to progesterone)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0032922"(circadian regulation of gene expression)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033142"(progesterone receptor binding)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0042974"(retinoic acid receptor binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043197"(dendritic spine)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045475"(locomotor rhythm)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045925"(positive regulation of female receptivity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046965"(retinoid X receptor binding)|go:"GO:0046966"(thyroid hormone receptor binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048786"(presynaptic active zone)|go:"GO:0070182"(DNA polymerase binding)|go:"GO:1904017"(cellular response to Thyroglobulin triiodothyronine)|go:"GO:2000324"(positive regulation of glucocorticoid receptor signaling pathway)|interpro:IPR000014(PAS)|interpro:IPR009110(Nuclear receptor coactivator, interlocking)|interpro:IPR010011(Protein of unknown function DUF1518)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR013767(PAS fold)|interpro:IPR014920(Nuclear receptor coactivator, Ncoa-type, interlocking)|interpro:IPR014935(Steroid receptor coactivator)|interpro:IPR017426(Nuclear receptor coactivator)|interpro:IPR028822|interpro:IPR032565|interpro:IPR035965|interpro:IPR036638|interpro:IPR037077|mint:Q61026|rcsb pdb:1L2I|rcsb pdb:1OSV|rcsb pdb:1WM0|rcsb pdb:2Q6J|rcsb pdb:2QA6|rcsb pdb:2QA8|rcsb pdb:2QAB|rcsb pdb:2QGT|rcsb pdb:2QGW|rcsb pdb:2QH6|rcsb pdb:2QPY|rcsb pdb:2QR9|rcsb pdb:2QSE|rcsb pdb:2QXM|rcsb pdb:2QZO|rcsb pdb:3MNE|rcsb pdb:3MNO|rcsb pdb:3MNP|reactome:R-MMU-159418|reactome:R-MMU-192105|reactome:R-MMU-193368|reactome:R-MMU-193807|reactome:R-MMU-211976|reactome:R-MMU-3214847|reactome:R-MMU-400206|reactome:R-MMU-5625886|reactome:R-MMU-9018519|reactome:R-MMU-9707564	-	afcs:35828(primary-reference)|afcs:55500(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:AfCS Y2H protein 35828. Translated from nucleotide sequence.|comment:"similar to EP300_HUMAN E1A-associated protein p300 (EC 2.3.1.48)(95%)."	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:NiMKYc0EqYC+ubVPFVRai8H/cNk10090	rogid:UF1glEKf3P+SmamnZPz30gYwQHM10090	intact-crc:56E608ABE3E40B9D|rigid:Gy80tbLuZJURI+EZA72a8+zdIJc	false	sufficient binding region:1014-1459	sufficient binding region:1730-1970	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688018	uniprotkb:Q99LE1	afcs:35826	intact:EBI-688699|uniprotkb:Q3TB73|ensembl:ENSMUSP00000031347	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:ripl2_mouse(display_long)|uniprotkb:Rab-interacting lysosomal-like protein 2(gene name synonym)|uniprotkb:Rilpl2(gene name)|psi-mi:Rilpl2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688801	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_084535.1|ensembl:ENSMUSG00000029401(gene)|ensembl:ENSMUST00000031347(transcript)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005929"(cilium)|go:"GO:0016020"(membrane)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042802"(identical protein binding)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0060271"(cilium assembly)|go:"GO:1903445"(protein transport from ciliary membrane to plasma membrane)|interpro:IPR021563|interpro:IPR034743|interpro:IPR034744|rcsb pdb:4KP3	afcs:35826(primary-reference)|afcs:30168(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	rogid:BiK3OWBdnz/agb+8dWxuQdXTaFE10090	intact-crc:B9F49942D2535BCA|rigid:2l6ECc8b7mK4/Wab78X8vyYMUmI	false	sufficient binding region:248-450	sufficient binding region:63-197	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0I9	intact:EBI-688018	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	afcs:35826	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688954	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	-	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	caution:The prey construct contains 4 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:7D5FA15DE75C5025|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:1-145	sufficient binding region:248-450	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0I9	intact:EBI-688018	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	afcs:35826	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688966	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	-	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	caution:The prey construct contains 4 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:B819A70F76DDA96F|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:1-352	sufficient binding region:248-450	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0I9	intact:EBI-688018	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	afcs:35826	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688978	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	-	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	caution:The prey construct contains 3 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:1F53E6E82C1E01A5|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:1-201	sufficient binding region:248-450	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0I9	intact:EBI-688018	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	afcs:35826	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-689014	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	-	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	caution:The prey construct contains 2 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:43DF9666E2EB9A0C|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:1-351	sufficient binding region:248-450	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D0I9	intact:EBI-688018	intact:EBI-529738|uniprotkb:Q8VDW1|uniprotkb:Q3THP2|uniprotkb:Q3TM73|uniprotkb:Q3U8R2|uniprotkb:Q3U930|uniprotkb:Q5SXA8|ensembl:ENSMUSP00000018992	afcs:35826	psi-mi:syrc_mouse(display_long)|uniprotkb:Rars1(gene name)|psi-mi:Rars1(display_short)|uniprotkb:Arginyl-tRNA synthetase(gene name synonym)|uniprotkb:Rars(gene name synonym)	psi-mi:rasa1_mouse_protein(display_short)|psi-mi:EBI-688018(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-689026	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080212.2|ensembl:ENSMUSG00000018848(gene)|ensembl:ENSMUST00000018992(transcript)|go:"GO:0000049"(tRNA binding)|go:"GO:0004814"(arginine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006420"(arginyl-tRNA aminoacylation)|go:"GO:0017101"(aminoacyl-tRNA synthetase multienzyme complex)|go:"GO:0034618"(arginine binding)|interpro:IPR001278(Arginyl-tRNA synthetase, class Ic)|interpro:IPR001412(Aminoacyl-tRNA synthetase, class I, conserved site)|interpro:IPR005148(Arginyl tRNA synthetase, class Ic, N-terminal)|interpro:IPR008909(DALR anticodon binding)|interpro:IPR009080(Aminoacyl-tRNA synthetase, class 1a, anticodon-binding)|interpro:IPR014729(Rossmann-like alpha/beta/alpha sandwich fold)|interpro:IPR035684|interpro:IPR036695|mint:Q9D0I9	-	afcs:35826(primary-reference)|afcs:40168(secondary-ac)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:RAS p21 protein activator 1; GTPase-activating protein; Gap; Rasa; RasGAP; p120-rasGAP|comment:AfCS Y2H protein 35826. Translated from nucleotide sequence.|comment:"Similar to RASA_RAT Ras GTPase-activating protein 1 (GTPase-activating protein) (92%)."	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1WhOMv/SKJ4+ILpXXgQKPx8Kqg10090	rogid:QW4Ig4NsOvD3T1Q4O0/TiotBd5810090	intact-crc:C1190A7BD9EEBB2C|rigid:O/cyXPDcEdbvhgnDKoZj0t60XBY	false	sufficient binding region:2-333	sufficient binding region:248-450	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08863	uniprotkb:P39429	intact:EBI-642236|uniprotkb:E9QLX3	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:birc3_mouse(display_long)|uniprotkb:Inhibitor of apoptosis protein 1(gene name synonym)|uniprotkb:Birc3(gene name)|psi-mi:Birc3(display_short)|uniprotkb:RING-type E3 ubiquitin transferase BIRC3(gene name synonym)|uniprotkb:Cellular inhibitor of apoptosis 2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658405	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031490.2|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016740"(transferase activity)|go:"GO:0031398"(positive regulation of protein ubiquitination)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042326"(negative regulation of phosphorylation)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043027"(cysteine-type endopeptidase inhibitor activity involved in apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046872"(metal ion binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060544"(regulation of necroptotic process)|go:"GO:0060546"(negative regulation of necroptotic process)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070266"(necroptotic process)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:1901222"(regulation of NIK/NF-kappaB signaling)|go:"GO:1902916"(positive regulation of protein polyubiquitination)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001315(Caspase Recruitment)|interpro:IPR001370(Proteinase inhibitor I32, inhibitor of apoptosis)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR011029(DEATH-like)|interpro:IPR041933|reactome:R-MMU-168638|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-937041|mint:O08863|dip:DIP-43742N	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:13827(secondary-ac)	-	-	caution:The prey construct contains 35 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rPZRfzbIHpwQop1BRwyZl+TfhUg10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:4C95F3B4558269BE|rigid:wHeVbAt+bLLgWVL8zorSZQCspSo	false	sufficient binding region:1-325	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3URD3	uniprotkb:P39429	intact:EBI-643207|uniprotkb:Q3TLP0|uniprotkb:Q3UIZ6|uniprotkb:Q6ZPL8|uniprotkb:Q8VC86|intact:EBI-647394|uniprotkb:Q9EQ03|ensembl:ENSMUSP00000117816	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:slmap_mouse(display_long)|uniprotkb:Slmap(gene name)|psi-mi:Slmap(display_short)|uniprotkb:Kiaa1601(gene name synonym)|uniprotkb:Slap(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658415	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_114397.3|refseq:NP_001297374.1|refseq:NP_001334423.1|ensembl:ENSMUSG00000021870(gene)|ensembl:ENSMUST00000139075(transcript)|go:"GO:0005615"(extracellular space)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0006936"(muscle contraction)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030018"(Z disc)|go:"GO:0031430"(M band)|go:"GO:0042383"(sarcolemma)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:1900825"(regulation of membrane depolarization during cardiac muscle cell action potential)|go:"GO:1902305"(regulation of sodium ion transmembrane transport)|go:"GO:1905150"(regulation of voltage-gated sodium channel activity)|interpro:IPR000253(Forkhead-associated)|interpro:IPR001363(Proteinase inhibitor I25C, fetuin, conserved site)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR030498|refseq:XP_017171716.1|refseq:XP_017171717.1	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:58183(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:KBjyLmT/EkqWeyWMydbyiGy1BjI10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:653354506ABE5FC3|rigid:yydYWVytiTShKxWRw4MbMQAfnOM	false	sufficient binding region:564-804	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648399	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	caution:The prey construct contains 26 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:BB38BA558BE68592|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:1-381	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648411	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:84ABB4AEFD03F7E3|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:79-372	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648441	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:FA20A74A64678260|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:183-443	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648461	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:9CA50EBD1EE57A68|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:230-430	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648481	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:71C633527979C94D|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:261-410	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648491	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:64861997EAE9B038|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:268-443	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P60764	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-644949|uniprotkb:O14658|ensembl:ENSMUSP00000018156	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:rac3_mouse(display_long)|uniprotkb:p21-Rac3(gene name synonym)|uniprotkb:Rac3(gene name)|psi-mi:Rac3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653444	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	refseq:NP_573486.1|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|ensembl:ENSMUSG00000018012(gene)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|ensembl:ENSMUST00000018156(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0071944"(cell periphery)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P60764|reactome:R-MMU-4086400|reactome:R-MMU-9013423	afcs:6614(secondary-ac)|afcs:35065(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:YWu9Tmqxzxu49RSwmyfhawoOUis10090	intact-crc:A8E4A6F6AB910A9C|rigid:gvzGKErrDMKHQ6YTL0Ephs3nQUo	false	sufficient binding region:261-410	sufficient binding region:1-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C2G0	uniprotkb:P39688	intact:EBI-645004	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:q8c2g0_mouse(display_long)|uniprotkb:Ptk2b(gene name)|psi-mi:Ptk2b(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653463	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR019749|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR019748|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR020635|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR029071|interpro:IPR041390|interpro:IPR030610|go:"GO:0007165"(signal transduction)|go:"GO:0007172"(signal complex assembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030500"(regulation of bone mineralization)|go:"GO:0001525"(angiogenesis)|go:"GO:0002688"(regulation of leukocyte chemotaxis)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005925"(focal adhesion)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042995"(cell projection)|go:"GO:0045765"(regulation of angiogenesis)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|interpro:IPR035963|interpro:IPR036137|interpro:IPR041784	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:40208(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Ti7RhQjmzsTUjA8jnRN9rn6v+ok10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:C8689ACEE189C87E|rigid:HUKHCvnQFrYGf9tuNGxZwkuqKnE	false	sufficient binding region:360-701	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61140	uniprotkb:P39688	intact:EBI-77088|uniprotkb:Q6PFF9|uniprotkb:Q60869|ensembl:ENSMUSP00000129584	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:bcar1_mouse(display_long)|uniprotkb:Bcar1(gene name)|psi-mi:Bcar1(display_short)|uniprotkb:Cas(gene name synonym)|uniprotkb:Crkas(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:CRK-associated substrate(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653473	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185768.1|refseq:NP_034084.2|rcsb pdb:5W93|reactome:R-MMU-186763|reactome:R-MMU-372708|reactome:R-MMU-4420097|reactome:R-MMU-8849471|ensembl:ENSMUSG00000031955(gene)|ensembl:ENSMUST00000166232(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990859"(cellular response to endothelin)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:Q61140	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:55282(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sbyvN4CE9k2skJV5C/LySCgu++E10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:2DD1911A8EC3C375|rigid:XRxB1K9AwZWMBf5euBLRTBBKUZE	false	sufficient binding region:621-874	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O55108	uniprotkb:E9PZQ0	intact:EBI-643315	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:o55108_mouse(display_long)|uniprotkb:Bsg(gene name)|psi-mi:Bsg(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650763	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|go:"GO:0005537"(mannose binding)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0007155"(cell adhesion)|go:"GO:0007411"(axon guidance)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|interpro:IPR036179|interpro:IPR043204|interpro:IPR044157	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34643(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:99x0BoyhEaFoUtTrud/7CV0STYg10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:4F79753F66731C41|rigid:wXBdjOi7vfF1uLDsJgUTMAFO6Wg	false	sufficient binding region:62-257	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61193	uniprotkb:P08556	intact:EBI-644290|uniprotkb:Q9QUJ2|ensembl:ENSMUSP00000041082	intact:EBI-644882	psi-mi:rgl2_mouse(display_long)|uniprotkb:RalGDS-like factor(gene name synonym)|uniprotkb:Ras-associated protein RAB2L(gene name synonym)|uniprotkb:Rgl2(gene name)|psi-mi:Rgl2(display_short)|uniprotkb:Rab2l(gene name synonym)|uniprotkb:Rlf(gene name synonym)	psi-mi:rasn_mouse(display_long)|uniprotkb:Transforming protein N-Ras(gene name synonym)|uniprotkb:Nras(gene name)|psi-mi:Nras(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653304	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033085.2|ensembl:ENSMUSG00000041354(gene)|ensembl:ENSMUST00000047503(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0032485"(regulation of Ral protein signal transduction)|interpro:IPR000159(Ras-association)|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR019804|interpro:IPR023578|interpro:IPR029071|interpro:IPR030749|interpro:IPR036964|rcsb pdb:1RLF|rcsb pdb:4JGW|rcsb pdb:5CM8|rcsb pdb:5CM9|reactome:R-MMU-5673001	reactome:R-MMU-9648002|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR001806(Ras GTPase)|interpro:IPR020849|interpro:IPR027417|go:"GO:0000139"(Golgi membrane)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001938"(positive regulation of endothelial cell proliferation)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0019003"(GDP binding)|go:"GO:0032729"(positive regulation of interferon-gamma production)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042832"(defense response to protozoan)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0016020"(membrane)|go:"GO:0048642"(negative regulation of skeletal muscle tissue development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0051726"(regulation of cell cycle)|reactome:R-MMU-1169092|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-171007|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-375165|reactome:R-MMU-5218921|reactome:R-MMU-5621575|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5658442|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-8849471|reactome:R-MMU-8851805|reactome:R-MMU-9634635|reactome:R-MMU-9607240	afcs:16488(primary-reference)|afcs:6853(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:nzMfBum+YeniQUocbEauEEzbniU10090	rogid:d/cSjl7Sse4v4T0S5ipO0mXomX410090	intact-crc:AF34B6F40749A307|rigid:8z6lOhfNlru2zdhuz64g0hkoGEs	false	sufficient binding region:490-778	sufficient binding region:1-171	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R1Q7	uniprotkb:P27870	intact:EBI-644894|uniprotkb:Q3U4I3|ensembl:ENSMUSP00000033486|ensembl:ENSMUSP00000132645	intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889	psi-mi:plp2_mouse(display_long)|uniprotkb:Plp2(gene name)|psi-mi:Plp2(display_short)	psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653315	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062729.1|ensembl:ENSMUST00000071118(transcript)|go:"GO:0005886"(plasma membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019956"(chemokine binding)|interpro:IPR008253(Marvel)|ensembl:ENSMUSG00000031146(gene)|ensembl:ENSMUSG00000057762(gene)|ensembl:ENSMUST00000033486(transcript)	refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809	afcs:55736(primary-reference)|afcs:18271(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qeo2iHgGYi7vTpfHycbLsnW6jks10090	rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090	intact-crc:2165C9D6F9AD212D|rigid:ezZ56vuwzOBxF4IWl8NIhC4jgJ4	false	sufficient binding region:23-152	sufficient binding region:150-390	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648368	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:567FF517E260C419|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:67-365	sufficient binding region:2-146	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648379	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:0CF363332E745624|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:125-443	sufficient binding region:2-146	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PT1	uniprotkb:P60764	intact:EBI-494354|uniprotkb:Q5M9P6|uniprotkb:Q8BPI0|uniprotkb:Q99KC4|ensembl:ENSMUSP00000063714|ensembl:ENSMUSP00000101803	intact:EBI-644949|uniprotkb:O14658|ensembl:ENSMUSP00000018156	psi-mi:gdir1_mouse(display_long)|uniprotkb:Rho-GDI alpha(gene name synonym)|uniprotkb:GDI-1(gene name synonym)|uniprotkb:Arhgdia(gene name)|psi-mi:Arhgdia(display_short)|uniprotkb:C87222(gene name synonym)|uniprotkb:Gdi1(gene name synonym)	psi-mi:rac3_mouse(display_long)|uniprotkb:p21-Rac3(gene name synonym)|uniprotkb:Rac3(gene name)|psi-mi:Rac3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653347	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006532612.1|refseq:NP_598557.3|ensembl:ENSMUST00000067936(transcript)|ensembl:ENSMUST00000106197(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071461"(cellular response to redox state)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024792|mint:Q99PT1|rcsb pdb:4F38|reactome:R-MMU-193634|reactome:R-MMU-209563|reactome:R-MMU-8980692|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013407|reactome:R-MMU-9013408|go:"GO:0071260"(cellular response to mechanical stimulus)|ensembl:ENSMUSG00000025132(gene)	refseq:NP_573486.1|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|ensembl:ENSMUSG00000018012(gene)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|ensembl:ENSMUST00000018156(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0071944"(cell periphery)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P60764|reactome:R-MMU-4086400|reactome:R-MMU-9013423	afcs:35065(primary-reference)|afcs:34645(secondary-ac)	-	-	caution:The prey construct contains 13 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T543bldr5c9EXiP1DXLnG6GuTsc10090	rogid:YWu9Tmqxzxu49RSwmyfhawoOUis10090	intact-crc:2C0C6258E9FA1BDD|rigid:JOXHixVvamjKd96lLtIGyqGtLFE	false	sufficient binding region:1-204	sufficient binding region:1-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61599	uniprotkb:P60764	intact:EBI-644961|uniprotkb:Q3TEB3|ensembl:ENSMUSP00000032344|ensembl:ENSMUSP00000107522|ensembl:ENSMUSP00000107523	intact:EBI-644949|uniprotkb:O14658|ensembl:ENSMUSP00000018156	psi-mi:gdir2_mouse(display_long)|uniprotkb:Rho-GDI beta(gene name synonym)|uniprotkb:D4(gene name synonym)|uniprotkb:Arhgdib(gene name)|psi-mi:Arhgdib(display_short)|uniprotkb:Gdid4(gene name synonym)	psi-mi:rac3_mouse(display_long)|uniprotkb:p21-Rac3(gene name synonym)|uniprotkb:Rac3(gene name)|psi-mi:Rac3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653366	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031512.1|refseq:NP_001288230.1|refseq:NP_001288232.1|refseq:NP_001288234.1|refseq:NP_001288237.1|refseq:NP_001288238.1|refseq:XP_006505467.1|ensembl:ENSMUSG00000030220(gene)|ensembl:ENSMUST00000032344(transcript)|ensembl:ENSMUST00000111891(transcript)|ensembl:ENSMUST00000111892(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0071461"(cellular response to redox state)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024792|mint:Q61599|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_573486.1|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|ensembl:ENSMUSG00000018012(gene)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|ensembl:ENSMUST00000018156(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0071944"(cell periphery)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P60764|reactome:R-MMU-4086400|reactome:R-MMU-9013423	afcs:35065(primary-reference)|afcs:35521(secondary-ac)	-	-	caution:The prey construct contains 19 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:q4GoTuJcORyPFUiFyFJNmGFkMog10090	rogid:YWu9Tmqxzxu49RSwmyfhawoOUis10090	intact-crc:A86FA6A7B0ACC265|rigid:NWkH0zeCHKDJzlWAGP1EsHqnqi4	false	sufficient binding region:1-164	sufficient binding region:1-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CW46	uniprotkb:P39688	intact:EBI-644967|uniprotkb:Q5DTT6|uniprotkb:Q811K0|uniprotkb:Q8C3Z1|uniprotkb:Q8CA14|ensembl:ENSMUSP00000111150|ensembl:ENSMUSP00000151195	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:ravr1_mouse(display_long)|uniprotkb:Protein raver-1(gene name synonym)|uniprotkb:Raver1(gene name)|psi-mi:Raver1(display_short)|uniprotkb:Kiaa1978(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653386	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082187.1|ensembl:ENSMUSG00000010205(gene)|ensembl:ENSMUSG00000111497(gene)|ensembl:ENSMUST00000115487(transcript)|ensembl:ENSMUST00000217359(transcript)|go:"GO:0000398"(mRNA splicing, via spliceosome)|go:"GO:0003676"(nucleic acid binding)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034633|interpro:IPR034635|interpro:IPR035979|mint:Q9CW46|rcsb pdb:1WI6|rcsb pdb:3ZZY|rcsb pdb:3ZZZ|dip:DIP-44609N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:31479(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8tlOX5yFmrXkpW1qGwJLK4alHqM10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:CA398E6F1F2E4CB5|rigid:h/ZpM9ECsfUo0gJe2ksf8TggedU	false	sufficient binding region:541-616	sufficient binding region:2-146	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BKT8	uniprotkb:P27870	intact:EBI-644976|uniprotkb:A2AIF2|intact:EBI-2553055|uniprotkb:Q924Z7|ensembl:ENSMUSP00000033737	intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889	psi-mi:haus7_mouse(display_long)|uniprotkb:Haus7(gene name)|psi-mi:Haus7(display_short)|uniprotkb:Uip1(gene name synonym)|uniprotkb:26S proteasome-associated UCH37-interacting protein 1(gene name synonym)|uniprotkb:Uchl5ip(gene name synonym)|uniprotkb:UCHL5-interacting protein(gene name synonym)	psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653396	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082909.1|refseq:NP_996987.1|ensembl:ENSMUSG00000031371(gene)|ensembl:ENSMUST00000033737(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0007098"(centrosome cycle)|go:"GO:0031996"(thioesterase binding)|go:"GO:0051011"(microtubule minus-end binding)|go:"GO:0051225"(spindle assembly)|go:"GO:0051301"(cell division)|go:"GO:0070652"(HAUS complex)|go:"GO:1990498"(mitotic spindle microtubule)|interpro:IPR029711|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-8854518	refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809	afcs:55736(primary-reference)|afcs:39862(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Hkg1fWoylAP4Ge0kcBVHZjFmcCU10090	rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090	intact-crc:3725F3277DB54530|rigid:EN3i8rsovPyGFitlQTXV+0IVyEs	false	sufficient binding region:224-364	sufficient binding region:150-390	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O89086	uniprotkb:Q8CBW3	intact:EBI-645649|ensembl:ENSMUSP00000111277|ensembl:ENSMUSP00000111282|ensembl:ENSMUSP00000111284	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:rbm3_mouse(display_long)|uniprotkb:RNA-binding motif protein 3(gene name synonym)|uniprotkb:Rbm3(gene name)|psi-mi:Rbm3(display_short)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654601	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001159882.1|refseq:NP_001159883.1|ensembl:ENSMUSG00000031167(gene)|ensembl:ENSMUST00000115615(transcript)|ensembl:ENSMUST00000115619(transcript)|ensembl:ENSMUST00000115621(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0006412"(translation)|go:"GO:0006417"(regulation of translation)|go:"GO:0009409"(response to cold)|go:"GO:0030425"(dendrite)|go:"GO:0035196"(production of miRNAs involved in gene silencing by miRNA)|go:"GO:0043023"(ribosomal large subunit binding)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034278|interpro:IPR035979|mint:O89086	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:12931(secondary-ac)	-	-	caution:The prey construct contains 19 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:loZc/KXvfUWniBvL99ZXgx7d9hQ10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:02D432E712F73AA4|rigid:mfonxC0c8kTlnQihDcnuelF8XQw	false	sufficient binding region:1-153	sufficient binding region:2-317	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70481	uniprotkb:Q62245	intact:EBI-645659|uniprotkb:A2AQ54|uniprotkb:Q5BKR8|uniprotkb:Q792M3|uniprotkb:Q8BN40|uniprotkb:Q8C5K3|ensembl:ENSMUSP00000028728	intact:EBI-1693|uniprotkb:Q62244|ensembl:ENSMUSP00000067786	psi-mi:ubr1_mouse(display_long)|uniprotkb:N-recognin-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-1(gene name synonym)|uniprotkb:Ubiquitin-protein ligase E3-alpha-I(gene name synonym)|uniprotkb:Ubr1(gene name)|psi-mi:Ubr1(display_short)|uniprotkb:RING-type E3 ubiquitin transferase UBR1(gene name synonym)	psi-mi:sos1_mouse(display_long)|uniprotkb:Sos1(gene name)|psi-mi:Sos1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654618	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033487.2|ensembl:ENSMUSG00000027272(gene)|ensembl:ENSMUST00000028728(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0000502"(proteasome complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0032007"(negative regulation of TOR signaling)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070728"(leucine binding)|go:"GO:0071233"(cellular response to leucine)|go:"GO:0071596"(ubiquitin-dependent protein catabolic process via the N-end rule pathway)|interpro:IPR003126(Zinc finger, N-recognin)|interpro:IPR003769(Adaptor protein ClpS, core)|interpro:IPR014719(Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like)|interpro:IPR036390|interpro:IPR039164|interpro:IPR044046|reactome:R-MMU-983168	refseq:NP_033257.2|dip:DIP-29230N|ensembl:ENSMUSG00000024241(gene)|ensembl:ENSMUST00000068714(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001942"(hair follicle development)|go:"GO:0002260"(lymphocyte homeostasis)|go:"GO:0003007"(heart morphogenesis)|go:"GO:0003209"(cardiac atrium morphogenesis)|go:"GO:0003344"(pericardium morphogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007296"(vitellogenesis)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0033081"(regulation of T cell differentiation in thymus)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045742"(positive regulation of epidermal growth factor receptor signaling pathway)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048514"(blood vessel morphogenesis)|go:"GO:0051057"(positive regulation of small GTPase mediated signal transduction)|go:"GO:0060021"(roof of mouth development)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061384"(heart trabecula morphogenesis)|go:"GO:1904693"(midbrain morphogenesis)|go:"GO:2000973"(regulation of pro-B cell differentiation)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR007125(Histone core)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR009072(Histone-fold)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR035899|interpro:IPR036964|mint:Q62245|rcsb pdb:1B07|rcsb pdb:1GBQ|rcsb pdb:1PMS|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180336|reactome:R-MMU-186763|reactome:R-MMU-193648|reactome:R-MMU-1963640|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-416482|reactome:R-MMU-5654688|reactome:R-MMU-5654693|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5673001|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8853659|reactome:R-MMU-8983432|reactome:R-MMU-9013149|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-9607240|reactome:R-MMU-983695	afcs:6871(primary-reference)|afcs:13860(secondary-ac)	-	crc64:3286088A5BA0A4A6	caution:The prey construct contains 4 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MSaRJnUGFioOkUOT0B0XM6ZxPtg10090	rogid:n5Gaz6esU+5ryBPr8s91dizgMnE10090	intact-crc:6B4F3D88BDB1E2EC|rigid:2aVt0M4IUT4/JZtgIFDDI8zED9U	false	sufficient binding region:1-161	sufficient binding region:558-759	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q09014	uniprotkb:Q8CBW3	intact:EBI-645700|uniprotkb:Q3UE58|uniprotkb:O70144|uniprotkb:Q9JI34|ensembl:ENSMUSP00000106906|ensembl:ENSMUSP00000138121	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:ncf1_mouse(display_long)|uniprotkb:Neutrophil NADPH oxidase factor 1(gene name synonym)|uniprotkb:47 kDa neutrophil oxidase factor(gene name synonym)|uniprotkb:p47-phox(gene name synonym)|uniprotkb:NCF-47K(gene name synonym)|uniprotkb:Ncf1(gene name)|psi-mi:Ncf1(display_short)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654660	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272966.1|refseq:NP_035006.3|dip:DIP-2665N|ensembl:ENSMUSG00000015950(gene)|ensembl:ENSMUST00000111275(transcript)|ensembl:ENSMUST00000146354(transcript)|go:"GO:0001878"(response to yeast)|go:"GO:0001909"(leukocyte mediated cytotoxicity)|go:"GO:0002679"(respiratory burst involved in defense response)|go:"GO:0005737"(cytoplasm)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006612"(protein targeting to membrane)|go:"GO:0006691"(leukotriene metabolic process)|go:"GO:0006742"(NADP catabolic process)|go:"GO:0006801"(superoxide metabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0006954"(inflammatory response)|go:"GO:0006968"(cellular defense response)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009617"(response to bacterium)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0016020"(membrane)|go:"GO:0016175"("superoxide-generating NAD(P)H oxidase activity")|go:"GO:0016176"(superoxide-generating NADPH oxidase activator activity)|go:"GO:0060090"(molecular adaptor activity)|go:"GO:0060264"(regulation of respiratory burst involved in inflammatory response)|go:"GO:0070946"(neutrophil-mediated killing of gram-positive bacterium)|go:"GO:0070947"(neutrophil-mediated killing of fungus)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:1903409"(reactive oxygen species biosynthetic process)|interpro:IPR001452(Src homology-3)|interpro:IPR001655(Neutrophil cytosol factor 1)|interpro:IPR001683(Phox-like)|interpro:IPR015039(NADPH oxidase subunit p47Phox, C terminal)|interpro:IPR032136|interpro:IPR034909|interpro:IPR035756|interpro:IPR035757|interpro:IPR036028|interpro:IPR036871|reactome:R-MMU-1222556|reactome:R-MMU-1236973|reactome:R-MMU-3299685|reactome:R-MMU-4420097|reactome:R-MMU-5668599|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|go:"GO:0019898"(extrinsic component of membrane)|go:"GO:0030425"(dendrite)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0042554"(superoxide anion generation)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0043020"(NADPH oxidase complex)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043325"(phosphatidylinositol-3,4-bisphosphate binding)|go:"GO:0045730"(respiratory burst)|go:"GO:0045741"(positive regulation of epidermal growth factor-activated receptor activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050665"(hydrogen peroxide biosynthetic process)|go:"GO:0050830"(defense response to Gram-positive bacterium)|go:"GO:0050832"(defense response to fungus)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:33718(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZWnBYkjZZ3PdwlX33lXRDd6H7AM10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:C5F8769F5CF6756A|rigid:Nqn9HiflzLkTEsjjM8bInRC/aHg	false	sufficient binding region:73-267	sufficient binding region:2-317	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70452	uniprotkb:Q8CBW3	intact:EBI-645716|ensembl:ENSMUSP00000033075|ensembl:ENSMUSP00000112927|uniprotkb:Q3TSL5|uniprotkb:Q3UKQ8|uniprotkb:Q80WT8	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:stx4_mouse(display_long)|uniprotkb:Stx4(gene name)|psi-mi:Stx4(display_short)|uniprotkb:Stx4a(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654670	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033320.1|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|ensembl:ENSMUSG00000030805(gene)|ensembl:ENSMUST00000033075(transcript)|ensembl:ENSMUST00000121705(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000322"(storage vacuole)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|dip:DIP-41399N|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016230"(sphingomyelin phosphodiesterase activator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030507"(spectrin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042383"(sarcolemma)|go:"GO:0042581"(specific granule)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043219"(lateral loop)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048278"(vesicle docking)|go:"GO:0048284"(organelle fusion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:P70452|rcsb pdb:3PUJ|rcsb pdb:3PUK|reactome:R-MMU-114516|reactome:R-MMU-1236974|reactome:R-MMU-199992|reactome:R-MMU-449836	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:15375(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rXjZl/EaKwHyd3Sl3aW5hbD6pbg10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:7C512D785E591E98|rigid:5qlyJ8LfaKS8cZJjQ9gaHskkNMY	false	sufficient binding region:79-268	sufficient binding region:2-317	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CBW3	uniprotkb:P70452	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	intact:EBI-645716|ensembl:ENSMUSP00000033075|ensembl:ENSMUSP00000112927|uniprotkb:Q3TSL5|uniprotkb:Q3UKQ8|uniprotkb:Q80WT8	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:stx4_mouse(display_long)|uniprotkb:Stx4(gene name)|psi-mi:Stx4(display_short)|uniprotkb:Stx4a(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654680	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	refseq:NP_033320.1|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009986"(cell surface)|go:"GO:0012505"(endomembrane system)|go:"GO:0016020"(membrane)|ensembl:ENSMUSG00000030805(gene)|ensembl:ENSMUST00000033075(transcript)|ensembl:ENSMUST00000121705(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0000322"(storage vacuole)|go:"GO:0002639"(positive regulation of immunoglobulin production)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006887"(exocytosis)|go:"GO:0006906"(vesicle fusion)|dip:DIP-41399N|go:"GO:0016021"(integral component of membrane)|go:"GO:0016079"(synaptic vesicle exocytosis)|go:"GO:0016081"(synaptic vesicle docking)|go:"GO:0016230"(sphingomyelin phosphodiesterase activator activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0017157"(regulation of exocytosis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030507"(spectrin binding)|go:"GO:0031201"(SNARE complex)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031629"(synaptic vesicle fusion to presynaptic active zone membrane)|go:"GO:0032589"(neuron projection membrane)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0035493"(SNARE complex assembly)|go:"GO:0035749"(myelin sheath adaxonal region)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036477"(somatodendritic compartment)|go:"GO:0042383"(sarcolemma)|go:"GO:0042581"(specific granule)|go:"GO:0043085"(positive regulation of catalytic activity)|go:"GO:0043197"(dendritic spine)|go:"GO:0043219"(lateral loop)|go:"GO:0043311"(positive regulation of eosinophil degranulation)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048278"(vesicle docking)|go:"GO:0048284"(organelle fusion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050921"(positive regulation of chemotaxis)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0061025"(membrane fusion)|go:"GO:0065003"(protein-containing complex assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:0098794"(postsynapse)|go:"GO:0098967"(exocytic insertion of neurotransmitter receptor to postsynaptic membrane)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099003"(vesicle-mediated transport in synapse)|go:"GO:1902041"(regulation of extrinsic apoptotic signaling pathway via death domain receptors)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:2000010"(positive regulation of protein localization to cell surface)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:P70452|rcsb pdb:3PUJ|rcsb pdb:3PUK|reactome:R-MMU-114516|reactome:R-MMU-1236974|reactome:R-MMU-199992|reactome:R-MMU-449836	afcs:33872(primary-reference)|afcs:15375(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	rogid:rXjZl/EaKwHyd3Sl3aW5hbD6pbg10090	intact-crc:57873A6EB0199715|rigid:5qlyJ8LfaKS8cZJjQ9gaHskkNMY	false	sufficient binding region:2-317	sufficient binding region:129-244	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CGI9	uniprotkb:O70172	intact:EBI-645739	intact:EBI-644828|ensembl:ENSMUSP00000006912	psi-mi:q8cgi9_mouse(display_long)|uniprotkb:Psmd1(gene name)|psi-mi:Psmd1(display_short)|uniprotkb:26S proteasome regulatory subunit RPN2(gene name synonym)|uniprotkb:26S proteasome regulatory subunit S1(gene name synonym)	psi-mi:pi42a_mouse(display_long)|uniprotkb:"PtdIns(5)P-4-kinase isoform 2-alpha"(gene name synonym)|uniprotkb:Diphosphoinositide kinase 2-alpha(gene name synonym)|uniprotkb:Pip4k2a(gene name)|psi-mi:Pip4k2a(display_short)|uniprotkb:Pip5k2a(gene name synonym)|uniprotkb:1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-phosphate 4-kinase type II alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 5-Phosphate 4-Kinase(gene name synonym)|uniprotkb:Pi5p4ka(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654701	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR016642(26S proteasome regulatory complex, non-ATPase subcomplex, Rpn2/Psmd1 subunit)|interpro:IPR002015(Proteasome/cyclosome, regulatory subunit)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR040623|go:"GO:0000502"(proteasome complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0042176"(regulation of protein catabolic process)|interpro:IPR035266	refseq:NP_032871.3|ensembl:ENSMUSG00000026737(gene)|ensembl:ENSMUST00000006912(transcript)|go:"GO:0001750"(photoreceptor outer segment)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005764"(lysosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0016309"(1-phosphatidylinositol-5-phosphate 4-kinase activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:0090119"(vesicle-mediated cholesterol transport)|go:"GO:0090217"(negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:1902635"(1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process)|go:"GO:2000786"(positive regulation of autophagosome assembly)|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|mint:O70172|reactome:R-MMU-1660499|reactome:R-MMU-6811555|reactome:R-MMU-6811558|reactome:R-MMU-8847453|dip:DIP-49438N	afcs:15014(primary-reference)|afcs:52566(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4VuUHSIdF4VOyLMCBxzBB4l5yDo10090	rogid:tnXc4oMaOV1P8hQRrM6/4G5CPOQ10090	intact-crc:21815A95A383ED3D|rigid:xREL0GKA8/D7/drWoUpvlyE8nxI	false	sufficient binding region:172-290	sufficient binding region:300-405	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61207	uniprotkb:P12367	intact:EBI-645756|uniprotkb:Q60861|uniprotkb:Q64006|uniprotkb:Q64219|ensembl:ENSMUSP00000137476	intact:EBI-645747	psi-mi:sap_mouse(display_long)|uniprotkb:Psap(gene name)|psi-mi:Psap(display_short)|uniprotkb:Sgp1(gene name synonym)|uniprotkb:Sulfated glycoprotein 1(gene name synonym)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654711	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139592.1|refseq:NP_001139593.1|refseq:NP_001139594.1|refseq:NP_001139595.1|refseq:NP_001139596.1|refseq:NP_035309.3|go:"GO:0003335"(corneocyte development)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005764"(lysosome)|go:"GO:0005770"(late endosome)|go:"GO:0006643"(membrane lipid metabolic process)|go:"GO:0006664"(glycolipid metabolic process)|go:"GO:0006665"(sphingolipid metabolic process)|go:"GO:0006672"(ceramide metabolic process)|go:"GO:0006678"(glucosylceramide metabolic process)|go:"GO:0006683"(galactosylceramide catabolic process)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007041"(lysosomal transport)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0002020"(protease binding)|go:"GO:0007605"(sensory perception of sound)|ensembl:ENSMUSG00000004207(gene)|ensembl:ENSMUST00000179238(transcript)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0010467"(gene expression)|go:"GO:0016235"(aggresome)|go:"GO:0019216"(regulation of lipid metabolic process)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0021702"(cerebellar Purkinje cell differentiation)|go:"GO:0030882"(lipid antigen binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042552"(myelination)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0048589"(developmental growth)|go:"GO:0050877"(nervous system process)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0051345"(positive regulation of hydrolase activity)|go:"GO:0060073"(micturition)|go:"GO:0060736"(prostate gland growth)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0009306"(protein secretion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0090102"(cochlea development)|go:"GO:0090659"(walking behavior)|go:"GO:1903206"(negative regulation of hydrogen peroxide-induced cell death)|go:"GO:1903575"(cornified envelope assembly)|go:"GO:1903771"(positive regulation of beta-galactosidase activity)|go:"GO:1905146"(lysosomal protein catabolic process)|go:"GO:1905572"(ganglioside GM1 transport to membrane)|go:"GO:1905573"(ganglioside GM1 binding)|go:"GO:1905574"(ganglioside GM2 binding)|go:"GO:1905575"(ganglioside GM3 binding)|go:"GO:1905576"(ganglioside GT1b binding)|go:"GO:1905577"(ganglioside GP1c binding)|interpro:IPR003119(Saposin type A)|interpro:IPR007856(Saposin-like type B, 1)|interpro:IPR008138(Saposin-like type B, 2)|interpro:IPR008139(Saposin B)|interpro:IPR008373(Saposin)|interpro:IPR011001(Saposin-like)|interpro:IPR021165|mint:Q61207|rcsb pdb:5NXB|rcsb pdb:5U85|reactome:R-MMU-114608|reactome:R-MMU-1660662|reactome:R-MMU-375276|reactome:R-MMU-418594|reactome:R-MMU-6798695|go:"GO:0070841"(inclusion body assembly)	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	afcs:19329(primary-reference)|afcs:16611(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:IOmtR34fe4aSy6aqmQvkB2xvuwU10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	intact-crc:4916FE5CF698E4FB|rigid:G1jHKbb9rdoc7dImt8uwRT08BP4	false	sufficient binding region:184-371	sufficient binding region:2-126	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88845	uniprotkb:P12367	intact:EBI-645773|uniprotkb:Q5SUB5|uniprotkb:Q5SUB7|uniprotkb:Q7TPE7|uniprotkb:Q8BQL6|ensembl:ENSMUSP00000099710	intact:EBI-645747	psi-mi:aka10_mouse(display_long)|uniprotkb:Protein kinase A-anchoring protein 10(gene name synonym)|uniprotkb:Dual specificity A kinase-anchoring protein 2(gene name synonym)|uniprotkb:Akap10(gene name)|psi-mi:Akap10(display_short)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654722	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064305.2|ensembl:ENSMUSG00000047804(gene)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0008104"(protein localization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0051018"(protein kinase A binding)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR036305|interpro:IPR037719|mint:O88845|reactome:R-MMU-983231|ensembl:ENSMUST00000102650(transcript)	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	afcs:19329(primary-reference)|afcs:11879(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:07HJ8UTUEOj2VvPiGvZHweTtWS810090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	intact-crc:4CAD178F2BE03F1B|rigid:vhF5aY237ZaRAtBUAtS9SEsf0xA	false	sufficient binding region:491-662	sufficient binding region:2-126	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QZ84	uniprotkb:Q8CBW3	intact:EBI-645799	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:q9qz84_mouse(display_long)|uniprotkb:Cenpf(gene name)|psi-mi:Cenpf(display_short)|uniprotkb:Lek1(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654742	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR043513|interpro:IPR019513|interpro:IPR018302|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0000922"(spindle pole)|go:"GO:0000940"(outer kinetochore)|go:"GO:0001822"(kidney development)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005819"(spindle)|go:"GO:0005930"(axoneme)|go:"GO:0008017"(microtubule binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010389"(regulation of G2/M transition of mitotic cell cycle)|go:"GO:0015031"(protein transport)|go:"GO:0016202"(regulation of striated muscle tissue development)|go:"GO:0016363"(nuclear matrix)|go:"GO:0021591"(ventricular system development)|go:"GO:0030496"(midbody)|go:"GO:0036064"(ciliary basal body)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0045120"(pronucleus)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0051310"(metaphase plate congression)|go:"GO:0070840"(dynein complex binding)|go:"GO:0097539"(ciliary transition fiber)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:0007059"(chromosome segregation)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:40292(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uSINHVUwfph6SoNuo5ImQlBOBxU10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:191DA99F1D2197DE|rigid:cNm6XJ5qeIhsXXAT53KvwwDsmkA	false	sufficient binding region:265-511	sufficient binding region:2-317	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54931-3	uniprotkb:P12367	intact:EBI-645828|ensembl:ENSMUSP00000099966|ensembl:ENSMUSP00000099967	intact:EBI-645747	psi-mi:o54931-3(display_long)|uniprotkb:Akap2(gene name)|psi-mi:Akap2(display_short)|uniprotkb:AKAP expressed in kidney and lung(gene name synonym)|uniprotkb:Protein kinase A-anchoring protein 2(gene name synonym)|uniprotkb:KL3A(isoform synonym)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654752	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645808(akap2_mouse)|ensembl:ENSMUSG00000038729(gene)|ensembl:ENSMUST00000102902(transcript)|ensembl:ENSMUST00000102903(transcript)	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	afcs:19329(primary-reference)|afcs:15654(secondary-ac)	isoform-comment:Produced by alternative splicing.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BmKdvJPFV+F8yvKjm35Js8ahxVw10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	intact-crc:4AFB9F584D0DF7A2|rigid:xWfPjo2vB/aeDijjX5Gv4oWcSuo	false	sufficient binding region:420-768	sufficient binding region:2-126	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P01872	uniprotkb:P12849	intact:EBI-645833|uniprotkb:P01873	intact:EBI-645585|ensembl:ENSMUSP00000026973|ensembl:ENSMUSP00000106515	psi-mi:ighm_mouse(display_long)|uniprotkb:Ighm(gene name)|psi-mi:Ighm(display_short)|uniprotkb:Igh-6(gene name synonym)	psi-mi:kap1_mouse(display_long)|uniprotkb:Prkar1b(gene name)|psi-mi:Prkar1b(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654782	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002455"(humoral immune response mediated by circulating immunoglobulin)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0003823"(antigen binding)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006910"(phagocytosis, recognition)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006958"(complement activation, classical pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016064"(immunoglobulin mediated immune response)|go:"GO:0019815"(B cell receptor complex)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030890"(positive regulation of B cell proliferation)|go:"GO:0034987"(immunoglobulin receptor binding)|go:"GO:0042571"(immunoglobulin complex, circulating)|go:"GO:0042742"(defense response to bacterium)|go:"GO:0042802"(identical protein binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045022"(early endosome to late endosome transport)|go:"GO:0045087"(innate immune response)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050778"(positive regulation of immune response)|go:"GO:0050829"(defense response to Gram-negative bacterium)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050871"(positive regulation of B cell activation)|rcsb pdb:4BA8|rcsb pdb:4JVU|rcsb pdb:4JVW|reactome:R-MMU-202733|reactome:R-MMU-5690714|reactome:R-MMU-983695|interpro:IPR036179|mint:P01872	refseq:NP_032949.3|refseq:XP_006504723.1|refseq:XP_006504724.1|refseq:XP_006504726.1|refseq:NP_001240819.1|refseq:XP_017176208.1|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0030552"(cAMP binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|go:"GO:0009887"(animal organ morphogenesis)|interpro:IPR018488|interpro:IPR018490|interpro:IPR042818|mint:P12849|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720|reactome:R-MMU-5610787|reactome:R-MMU-983231|ensembl:ENSMUSG00000025855(gene)|ensembl:ENSMUST00000026973(transcript)|ensembl:ENSMUST00000110890(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007611"(learning or memory)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)	afcs:15079(primary-reference)|afcs:15079(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4+PnUlhyUfPZS43gGZMtyePhlCw10090	rogid:w65y6gB5uVAjfKjbAidQPpWtgAo10090	intact-crc:8423F75D6C77315A|rigid:jV2ngnuZzGuqPxG5faXtXxwF4vA	false	sufficient binding region:?-?	sufficient binding region:2-381	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P11835	uniprotkb:Q9DBC7	intact:EBI-644501|uniprotkb:Q64482	intact:EBI-645677|uniprotkb:Q3UKU7|uniprotkb:Q9JHR5|uniprotkb:Q9JHR6|ensembl:ENSMUSP00000056500|ensembl:ENSMUSP00000102288	psi-mi:itb2_mouse(display_long)|uniprotkb:Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta(gene name synonym)|uniprotkb:Complement receptor C3 subunit beta(gene name synonym)|uniprotkb:Itgb2(gene name)|psi-mi:Itgb2(display_short)	psi-mi:kap0_mouse(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654793	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_032430.2|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001851"(complement component C3b binding)|go:"GO:0002523"(leukocyte migration involved in inflammatory response)|go:"GO:0005178"(integrin binding)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006898"(receptor-mediated endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030369"(ICAM-3 receptor activity)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0031072"(heat shock protein binding)|go:"GO:0031623"(receptor internalization)|go:"GO:0032930"(positive regulation of superoxide anion generation)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034687"(integrin alphaL-beta2 complex)|go:"GO:0034688"(integrin alphaM-beta2 complex)|go:"GO:0043113"(receptor clustering)|go:"GO:0043235"(receptor complex)|go:"GO:0043315"(positive regulation of neutrophil degranulation)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045123"(cellular extravasation)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0046872"(metal ion binding)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0097242"(amyloid-beta clearance)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:1990266"(neutrophil migration)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015439(Integrin beta-2 subunit, C-terminal)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|reactome:R-MMU-166016|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-216083|reactome:R-MMU-6798695|dip:DIP-37428N|mint:P11835	refseq:NP_001300902.1|refseq:NP_001300903.1|refseq:NP_001300904.1|refseq:NP_001300905.1|refseq:NP_068680.1|refseq:XP_017169829.1|dip:DIP-32450N|ensembl:ENSMUSG00000020612(gene)|ensembl:ENSMUST00000049527(transcript)|ensembl:ENSMUST00000106677(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-983231|reactome:R-MMU-5610787|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:Q9DBC7|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|go:"GO:0043949"(regulation of cAMP-mediated signaling)|reactome:R-MMU-442720	afcs:20225(primary-reference)|afcs:14656(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:a6PSt0Keij+/xNNHH2GNomc28SM10090	rogid:0KqlQxZjK8QfS6VPEiTDtvHNTj410090	intact-crc:4F2E114C15F0AEA2|rigid:eVjNd08YSsaphRkNV1FR4geeNvo	false	sufficient binding region:637-771	sufficient binding region:119-325	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R0I7	uniprotkb:Q8CBW3	intact:EBI-644694|uniprotkb:E9QKY3|uniprotkb:Q7TMM4|ensembl:ENSMUSP00000098763	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:ylpm1_mouse(display_long)|uniprotkb:Nuclear protein ZAP3(gene name synonym)|uniprotkb:Ylpm1(gene name)|psi-mi:Ylpm1(display_short)|uniprotkb:Zap(gene name synonym)|uniprotkb:Zap3(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654803	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0032204"(regulation of telomere maintenance)|interpro:IPR026314|ensembl:ENSMUSG00000021244(gene)|ensembl:ENSMUST00000101202(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|interpro:IPR027417|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|mint:Q9R0I7|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0016607"(nuclear speck)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:33546(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+1aQLNgVl385Mxmx32eA6x9ccDg10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:A271E612B3C4412C|rigid:LkO0A1Tp/e+Y/SJ0LzNllkEgOuY	false	sufficient binding region:797-933	sufficient binding region:2-317	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q69ZK0	uniprotkb:Q8CBW3	intact:EBI-645862|uniprotkb:A2A5U1|uniprotkb:Q6PFD4|uniprotkb:Q8BN08|ensembl:ENSMUSP00000037180	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:prex1_mouse(display_long)|uniprotkb:Prex1(gene name)|psi-mi:Prex1(display_short)|uniprotkb:Kiaa1415(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654823	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_808450.2|ensembl:ENSMUSG00000039621(gene)|ensembl:ENSMUST00000036719(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005543"(phospholipid binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030426"(growth cone)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050773"(regulation of dendrite development)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000591(Pleckstrin/ G-protein, interacting region)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR035899|interpro:IPR036034|interpro:IPR036388|interpro:IPR036390|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013408|reactome:R-MMU-9013409|reactome:R-MMU-9013423|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:33872(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZIutFFrewJcYdGQ2jnIHauqR03k10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:F82603468FE8B850|rigid:7BdV7dl06B/BMK/WeKMDktwLQbI	false	sufficient binding region:989-1234	sufficient binding region:2-317	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61179	uniprotkb:Q9QXJ2	intact:EBI-646653|ensembl:ENSMUSP00000120359	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:irf9_mouse(display_long)|uniprotkb:Isgf3g(gene name synonym)|uniprotkb:Transcriptional regulator ISGF3 subunit gamma(gene name synonym)|uniprotkb:IFN-alpha-responsive transcription factor subunit(gene name synonym)|uniprotkb:Interferon-stimulated gene factor 3 gamma(gene name synonym)|uniprotkb:ISGF3 p48 subunit(gene name synonym)|uniprotkb:Irf9(gene name)|psi-mi:Irf9(display_short)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656590	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152889.1|refseq:NP_001152890.1|refseq:NP_032420.1|reactome:R-MMU-909733|rcsb pdb:5OEN|ensembl:ENSMUSG00000002325(gene)|ensembl:ENSMUST00000130697(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5OEM	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:14647(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JHbDnrkiCtNJ9ktn4N0RE3lk21E10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:4B7B18C7BF1D15C7|rigid:GFChxDWvYbBnzQ5GgTqeUn2w0+o	false	sufficient binding region:62-339	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61179	uniprotkb:Q9QXJ2	intact:EBI-646653|ensembl:ENSMUSP00000120359	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:irf9_mouse(display_long)|uniprotkb:Isgf3g(gene name synonym)|uniprotkb:Transcriptional regulator ISGF3 subunit gamma(gene name synonym)|uniprotkb:IFN-alpha-responsive transcription factor subunit(gene name synonym)|uniprotkb:Interferon-stimulated gene factor 3 gamma(gene name synonym)|uniprotkb:ISGF3 p48 subunit(gene name synonym)|uniprotkb:Irf9(gene name)|psi-mi:Irf9(display_short)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656601	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152889.1|refseq:NP_001152890.1|refseq:NP_032420.1|reactome:R-MMU-909733|rcsb pdb:5OEN|ensembl:ENSMUSG00000002325(gene)|ensembl:ENSMUST00000130697(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5OEM	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:14647(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JHbDnrkiCtNJ9ktn4N0RE3lk21E10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:1AEAE24713CC1E67|rigid:GFChxDWvYbBnzQ5GgTqeUn2w0+o	false	sufficient binding region:90-339	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61179	uniprotkb:Q9QXJ2	intact:EBI-646653|ensembl:ENSMUSP00000120359	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:irf9_mouse(display_long)|uniprotkb:Isgf3g(gene name synonym)|uniprotkb:Transcriptional regulator ISGF3 subunit gamma(gene name synonym)|uniprotkb:IFN-alpha-responsive transcription factor subunit(gene name synonym)|uniprotkb:Interferon-stimulated gene factor 3 gamma(gene name synonym)|uniprotkb:ISGF3 p48 subunit(gene name synonym)|uniprotkb:Irf9(gene name)|psi-mi:Irf9(display_short)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656611	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152889.1|refseq:NP_001152890.1|refseq:NP_032420.1|reactome:R-MMU-909733|rcsb pdb:5OEN|ensembl:ENSMUSG00000002325(gene)|ensembl:ENSMUST00000130697(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5OEM	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:14647(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JHbDnrkiCtNJ9ktn4N0RE3lk21E10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:D53CD5C8A89F9F5D|rigid:GFChxDWvYbBnzQ5GgTqeUn2w0+o	false	sufficient binding region:114-339	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61179	uniprotkb:Q9QXJ2	intact:EBI-646653|ensembl:ENSMUSP00000120359	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:irf9_mouse(display_long)|uniprotkb:Isgf3g(gene name synonym)|uniprotkb:Transcriptional regulator ISGF3 subunit gamma(gene name synonym)|uniprotkb:IFN-alpha-responsive transcription factor subunit(gene name synonym)|uniprotkb:Interferon-stimulated gene factor 3 gamma(gene name synonym)|uniprotkb:ISGF3 p48 subunit(gene name synonym)|uniprotkb:Irf9(gene name)|psi-mi:Irf9(display_short)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656621	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152889.1|refseq:NP_001152890.1|refseq:NP_032420.1|reactome:R-MMU-909733|rcsb pdb:5OEN|ensembl:ENSMUSG00000002325(gene)|ensembl:ENSMUST00000130697(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5OEM	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:14647(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JHbDnrkiCtNJ9ktn4N0RE3lk21E10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:8332EDDB99D3BDE1|rigid:GFChxDWvYbBnzQ5GgTqeUn2w0+o	false	sufficient binding region:123-339	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61179	uniprotkb:Q9QXJ2	intact:EBI-646653|ensembl:ENSMUSP00000120359	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:irf9_mouse(display_long)|uniprotkb:Isgf3g(gene name synonym)|uniprotkb:Transcriptional regulator ISGF3 subunit gamma(gene name synonym)|uniprotkb:IFN-alpha-responsive transcription factor subunit(gene name synonym)|uniprotkb:Interferon-stimulated gene factor 3 gamma(gene name synonym)|uniprotkb:ISGF3 p48 subunit(gene name synonym)|uniprotkb:Irf9(gene name)|psi-mi:Irf9(display_short)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656631	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152889.1|refseq:NP_001152890.1|refseq:NP_032420.1|reactome:R-MMU-909733|rcsb pdb:5OEN|ensembl:ENSMUSG00000002325(gene)|ensembl:ENSMUST00000130697(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5OEM	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:14647(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JHbDnrkiCtNJ9ktn4N0RE3lk21E10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:BA0FD7B6E482AECD|rigid:GFChxDWvYbBnzQ5GgTqeUn2w0+o	false	sufficient binding region:127-339	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61179	uniprotkb:Q9QXJ2	intact:EBI-646653|ensembl:ENSMUSP00000120359	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:irf9_mouse(display_long)|uniprotkb:Isgf3g(gene name synonym)|uniprotkb:Transcriptional regulator ISGF3 subunit gamma(gene name synonym)|uniprotkb:IFN-alpha-responsive transcription factor subunit(gene name synonym)|uniprotkb:Interferon-stimulated gene factor 3 gamma(gene name synonym)|uniprotkb:ISGF3 p48 subunit(gene name synonym)|uniprotkb:Irf9(gene name)|psi-mi:Irf9(display_short)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656641	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152889.1|refseq:NP_001152890.1|refseq:NP_032420.1|reactome:R-MMU-909733|rcsb pdb:5OEN|ensembl:ENSMUSG00000002325(gene)|ensembl:ENSMUST00000130697(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5OEM	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:14647(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JHbDnrkiCtNJ9ktn4N0RE3lk21E10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:A2D54DD74A066564|rigid:GFChxDWvYbBnzQ5GgTqeUn2w0+o	false	sufficient binding region:161-339	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61179	uniprotkb:Q9QXJ2	intact:EBI-646653|ensembl:ENSMUSP00000120359	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:irf9_mouse(display_long)|uniprotkb:Isgf3g(gene name synonym)|uniprotkb:Transcriptional regulator ISGF3 subunit gamma(gene name synonym)|uniprotkb:IFN-alpha-responsive transcription factor subunit(gene name synonym)|uniprotkb:Interferon-stimulated gene factor 3 gamma(gene name synonym)|uniprotkb:ISGF3 p48 subunit(gene name synonym)|uniprotkb:Irf9(gene name)|psi-mi:Irf9(display_short)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656651	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152889.1|refseq:NP_001152890.1|refseq:NP_032420.1|reactome:R-MMU-909733|rcsb pdb:5OEN|ensembl:ENSMUSG00000002325(gene)|ensembl:ENSMUST00000130697(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5OEM	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:14647(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JHbDnrkiCtNJ9ktn4N0RE3lk21E10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:0B5AD13430A5FC7D|rigid:GFChxDWvYbBnzQ5GgTqeUn2w0+o	false	sufficient binding region:172-339	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QXJ2	uniprotkb:Q61179	intact:EBI-646643|ensembl:ENSMUSP00000082855	intact:EBI-646653|ensembl:ENSMUSP00000120359	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:irf9_mouse(display_long)|uniprotkb:Isgf3g(gene name synonym)|uniprotkb:Transcriptional regulator ISGF3 subunit gamma(gene name synonym)|uniprotkb:IFN-alpha-responsive transcription factor subunit(gene name synonym)|uniprotkb:Interferon-stimulated gene factor 3 gamma(gene name synonym)|uniprotkb:ISGF3 p48 subunit(gene name synonym)|uniprotkb:Irf9(gene name)|psi-mi:Irf9(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656661	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	refseq:NP_001152889.1|refseq:NP_001152890.1|refseq:NP_032420.1|reactome:R-MMU-909733|rcsb pdb:5OEN|ensembl:ENSMUSG00000002325(gene)|ensembl:ENSMUST00000130697(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0002376"(immune system process)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR001346(Interferon regulatory factor)|interpro:IPR008984(SMAD/FHA domain)|interpro:IPR017855(SMAD domain-like)|interpro:IPR019471|interpro:IPR019817|interpro:IPR036388|interpro:IPR036390|rcsb pdb:5OEM	afcs:18399(primary-reference)|afcs:14647(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	rogid:JHbDnrkiCtNJ9ktn4N0RE3lk21E10090	intact-crc:FB0391977CC0F494|rigid:GFChxDWvYbBnzQ5GgTqeUn2w0+o	false	sufficient binding region:1-300	sufficient binding region:203-339	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88544	uniprotkb:Q9QXJ2	intact:EBI-646659|ensembl:ENSMUSP00000048416	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:csn4_mouse(display_long)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym)|uniprotkb:Cops4(gene name)|psi-mi:Cops4(display_short)|uniprotkb:Csn4(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656681	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036131.1|ensembl:ENSMUSG00000035297(gene)|ensembl:ENSMUST00000045993(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:O88544|rcsb pdb:1UFM|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:17150(secondary-ac)	-	-	caution:The prey construct contains 4 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:oD7xaeBArd5bKxdEAWM/r+5KMb010090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:57631F738560BAC5|rigid:5qsyKrwiKj5PKCK6c2f/41mgovI	false	sufficient binding region:1-141	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88544	uniprotkb:Q9QXJ2	intact:EBI-646659|ensembl:ENSMUSP00000048416	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:csn4_mouse(display_long)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym)|uniprotkb:Cops4(gene name)|psi-mi:Cops4(display_short)|uniprotkb:Csn4(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656701	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036131.1|ensembl:ENSMUSG00000035297(gene)|ensembl:ENSMUST00000045993(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:O88544|rcsb pdb:1UFM|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:17150(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:oD7xaeBArd5bKxdEAWM/r+5KMb010090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:BC5621573DDD70C9|rigid:5qsyKrwiKj5PKCK6c2f/41mgovI	false	sufficient binding region:119-406	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88544	uniprotkb:Q9QXJ2	intact:EBI-646659|ensembl:ENSMUSP00000048416	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:csn4_mouse(display_long)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym)|uniprotkb:Cops4(gene name)|psi-mi:Cops4(display_short)|uniprotkb:Csn4(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656711	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036131.1|ensembl:ENSMUSG00000035297(gene)|ensembl:ENSMUST00000045993(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:O88544|rcsb pdb:1UFM|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:17150(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:oD7xaeBArd5bKxdEAWM/r+5KMb010090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:74E5B00B04FEF552|rigid:5qsyKrwiKj5PKCK6c2f/41mgovI	false	sufficient binding region:255-406	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88544	uniprotkb:Q9QXJ2	intact:EBI-646659|ensembl:ENSMUSP00000048416	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:csn4_mouse(display_long)|uniprotkb:JAB1-containing signalosome subunit 4(gene name synonym)|uniprotkb:Cops4(gene name)|psi-mi:Cops4(display_short)|uniprotkb:Csn4(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656731	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036131.1|ensembl:ENSMUSG00000035297(gene)|ensembl:ENSMUST00000045993(transcript)|go:"GO:0000338"(protein deneddylation)|go:"GO:0005829"(cytosol)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0016607"(nuclear speck)|go:"GO:0030054"(cell junction)|interpro:IPR000717(Proteasome component region PCI)|interpro:IPR036388|interpro:IPR036390|interpro:IPR037754|interpro:IPR040134|interpro:IPR041406|mint:O88544|rcsb pdb:1UFM|reactome:R-MMU-5696394|reactome:R-MMU-6781823|reactome:R-MMU-8856825|reactome:R-MMU-8951664|reactome:R-MMU-9013422	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:17150(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:oD7xaeBArd5bKxdEAWM/r+5KMb010090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:AEC7B3A08CE8D44D|rigid:5qsyKrwiKj5PKCK6c2f/41mgovI	false	sufficient binding region:277-406	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ERR1	uniprotkb:Q9QXJ2	intact:EBI-646668|uniprotkb:Q9D0Q4|uniprotkb:Q9EPT6|ensembl:ENSMUSP00000018880	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:ndel1_mouse(display_long)|uniprotkb:Protein mNudE-like(gene name synonym)|uniprotkb:Ndel1(gene name)|psi-mi:Ndel1(display_short)|uniprotkb:Nudel(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656741	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076157.2|dip:DIP-29553N|ensembl:ENSMUSG00000018736(gene)|ensembl:ENSMUST00000018880(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0000776"(kinetochore)|go:"GO:0001764"(neuron migration)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0005871"(kinesin complex)|go:"GO:0005874"(microtubule)|go:"GO:0005875"(microtubule associated complex)|go:"GO:0007020"(microtubule nucleation)|go:"GO:0007059"(chromosome segregation)|go:"GO:0007100"(mitotic centrosome separation)|go:"GO:0008017"(microtubule binding)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010975"(regulation of neuron projection development)|go:"GO:0016477"(cell migration)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0030424"(axon)|go:"GO:0031175"(neuron projection development)|go:"GO:0031252"(cell leading edge)|go:"GO:0032418"(lysosome localization)|go:"GO:0033157"(regulation of intracellular protein transport)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043203"(axon hillock)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044297"(cell body)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0047496"(vesicle transport along microtubule)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048680"(positive regulation of axon regeneration)|go:"GO:0051081"(nuclear membrane disassembly)|go:"GO:0051303"(establishment of chromosome localization)|go:"GO:0051642"(centrosome localization)|go:"GO:0060052"(neurofilament cytoskeleton organization)|go:"GO:0060053"(neurofilament cytoskeleton)|go:"GO:0070012"(oligopeptidase activity)|go:"GO:0090630"(activation of GTPase activity)|go:"GO:0090724"(central region of growth cone)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1990138"(neuron projection extension)|go:"GO:2000574"(obsolete regulation of microtubule motor activity)|interpro:IPR033493|interpro:IPR033494|mint:Q9ERR1|rcsb pdb:5YI4|rcsb pdb:6KZJ|reactome:R-MMU-141444|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|interpro:IPR006964(NUDE protein, C-terminal)	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:34669(secondary-ac)	-	-	caution:The prey construct contains 41 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c69FdVwX1uLP9KZrbrhxKlgGO3c10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:9E5052CF3AFE43DD|rigid:60+UvRZ5F0p7Zk0bcdWkttrxtFU	false	sufficient binding region:1-186	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QX11	uniprotkb:Q9QXJ2	intact:EBI-646678|uniprotkb:Q76MU4|uniprotkb:O88817|ensembl:ENSMUSP00000101912	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:cyh1_mouse(display_long)|uniprotkb:PH, SEC7 and coiled-coil domain-containing protein 1(gene name synonym)|uniprotkb:SEC7 homolog A(gene name synonym)|uniprotkb:Cyth1(gene name)|psi-mi:Cyth1(display_short)|uniprotkb:Pscd1(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656762	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001106169.1|refseq:NP_035310.2|ensembl:ENSMUSG00000017132(gene)|ensembl:ENSMUST00000106305(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0008289"(lipid binding)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0032012"(regulation of ARF protein signal transduction)|go:"GO:0090162"(establishment of epithelial cell polarity)|go:"GO:0098888"(extrinsic component of presynaptic membrane)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|interpro:IPR000904(SEC7-like)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR023394|interpro:IPR035999|reactome:R-MMU-6811438	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:16612(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Cl1DtnqE/FsMVxm9QZko6yMX+Ds10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:C75217ED24397E3B|rigid:rGlsyXt/GPB/6iegy4WEV4ydZto	false	sufficient binding region:9-208	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6ZQ38	uniprotkb:Q9QXJ2	intact:EBI-597255|uniprotkb:Q6PFR0|uniprotkb:Q9CV45|ensembl:ENSMUSP00000020315	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:cand1_mouse(display_long)|uniprotkb:Cullin-associated and neddylation-dissociated protein 1(gene name synonym)|uniprotkb:p120 CAND1(gene name synonym)|uniprotkb:Cand1(gene name)|psi-mi:Cand1(display_short)|uniprotkb:D10Ertd516e(gene name synonym)|uniprotkb:Kiaa0829(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656772	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082270.1|ensembl:ENSMUSG00000020114(gene)|ensembl:ENSMUST00000020315(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0010265"(SCF complex assembly)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017025"(TBP-class protein binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0031461"(cullin-RING ubiquitin ligase complex)|go:"GO:0043086"(negative regulation of catalytic activity)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045899"(positive regulation of RNA polymerase II transcription preinitiation complex assembly)|interpro:IPR013932("TATA-binding protein interacting (TIP20)")|interpro:IPR016024(Armadillo-type fold)|interpro:IPR039852|mint:Q6ZQ38|reactome:R-MMU-6798695|reactome:R-MMU-8951664|reactome:R-MMU-917937	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:58119(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:E6bJujLfT/V3C8Iyk0hUD1m4gT010090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:5FAA437F964AC4BE|rigid:iYsZEvrvV1DoF4bu+nwoLTJQCCI	false	sufficient binding region:318-734	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DBZ2	uniprotkb:P39428	intact:EBI-646701	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:q9dbz2_mouse(display_long)|uniprotkb:Spop(gene name)|psi-mi:Spop(display_short)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656782	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079563.2|interpro:IPR000210(BTB/POZ-like)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:20652(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0gZCAz2RkWd/4EqGRXxKaJ+0c2410090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:EEC953F2156F82F5|rigid:7r8CGacWoOT6QHPZWPRR7MzoWiI	false	sufficient binding region:33-425	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656793	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 18 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:9AE05F0CCC8B56DC|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:1-229	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656803	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 18 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:617D213D3014F1EC|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:1-369	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656813	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 16 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:425020E18940A174|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:1-220	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656823	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:16826(secondary-ac)|afcs:55765(primary-reference)	-	-	caution:The prey construct contains 16 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:3FB83ED436761011|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:1-318	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656833	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 8 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:08E6473F18C5EF10|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:1-225	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656853	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 7 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:CA6552CB030B5D3F|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:1-444	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656863	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 1 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:D0E591C5927B9E59|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:1-369	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39428	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656903	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:16826(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:9409EA158F772E3B|rigid:asgeUVYxs0kXKJFWCogPdZMuZ6A	false	sufficient binding region:173-318	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C886	uniprotkb:P39428	intact:EBI-646708|uniprotkb:Q8R3H1|uniprotkb:A0A1W2P6Q7|uniprotkb:A0A1W2P7X5|ensembl:ENSMUSP00000151799	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:pkhn1_mouse(display_long)|uniprotkb:Plekhn1(gene name)|psi-mi:Plekhn1(display_short)|uniprotkb:Cardiolipin and phosphatidic acid-binding protein(gene name synonym)|uniprotkb:Clpabp(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656933	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000078485(gene)|ensembl:ENSMUST00000217885(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0005739"(mitochondrion)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0061158"(3'-UTR-mediated mRNA destabilization)|go:"GO:0070300"(phosphatidic acid binding)|go:"GO:1901612"(cardiolipin binding)|go:"GO:1901981"(phosphatidylinositol phosphate binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR042835	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:58120(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2018/10/11	rogid:mIzWRQmmgEyEzjsKvhnwbO1Frgw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:DC50435B0DE9B39B|rigid:tO4nwY0LpWX+MNgkDcCadhFlT10	false	sufficient binding region:?-?	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q924A0	uniprotkb:P39428	intact:EBI-646713|uniprotkb:O70574|uniprotkb:Q91XP2|uniprotkb:Q91XP3|uniprotkb:Q91XP4|uniprotkb:Q924A1|uniprotkb:Q9Z0V3|uniprotkb:Q9Z0V4|uniprotkb:Q8C834	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:tf7l2_mouse(display_long)|uniprotkb:HMG box transcription factor 4(gene name synonym)|uniprotkb:T-cell-specific transcription factor 4(gene name synonym)|uniprotkb:Tcf7l2(gene name)|psi-mi:Tcf7l2(display_short)|uniprotkb:Tcf4(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656993	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001136393.1|refseq:NP_001136396.1|dip:DIP-40920N|refseq:NP_001136390.1|mint:Q924A0|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009749"(response to glucose)|go:"GO:0009791"(post-embryonic development)|go:"GO:0010867"(positive regulation of triglyceride biosynthetic process)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0016605"(PML body)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021915"(neural tube development)|go:"GO:0021983"(pituitary gland development)|go:"GO:0030282"(bone mineralization)|go:"GO:0030514"(negative regulation of BMP signaling pathway)|go:"GO:0030538"(embryonic genitalia morphogenesis)|go:"GO:0031641"(regulation of myelination)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032092"(positive regulation of protein binding)|go:"GO:0032252"(secretory granule localization)|go:"GO:0032350"(regulation of hormone metabolic process)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0035019"(somatic stem cell population maintenance)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0040037"(negative regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043433"(negative regulation of DNA-binding transcription factor activity)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043570"(maintenance of DNA repeat elements)|go:"GO:0043588"(skin development)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0045295"(gamma-catenin binding)|go:"GO:0045444"(fat cell differentiation)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045722"(positive regulation of gluconeogenesis)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0046889"(positive regulation of lipid biosynthetic process)|go:"GO:0048557"(embryonic digestive tract morphogenesis)|go:"GO:0048619"(embryonic hindgut morphogenesis)|go:"GO:0048625"(myoblast fate commitment)|go:"GO:0048641"(regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048713"(regulation of oligodendrocyte differentiation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060325"(face morphogenesis)|go:"GO:0061178"(regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070016"(armadillo repeat domain binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0071664"(catenin-TCF7L2 complex)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1901142"(insulin metabolic process)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:2000675"(negative regulation of type B pancreatic cell apoptotic process)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR013558(CTNNB1 binding, N-teminal)|interpro:IPR024940|interpro:IPR027397|interpro:IPR036910|reactome:R-MMU-201722|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-4641265|reactome:R-MMU-8853884|reactome:R-MMU-8951430|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001568"(blood vessel development)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005829"(cytosol)|go:"GO:0005977"(glycogen metabolic process)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006355"(regulation of transcription, DNA-templated)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:15412(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sg7QuRHMz8m1+v07Fmk+iPachlw10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:1C5219F3C8043DB5|rigid:SAp2ddgMruSp2irgtdD9Vs+GqfY	false	sufficient binding region:47-278	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:Q99M51	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651809	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:7326(primary-reference)|afcs:6614(secondary-ac)	-	-	caution:The prey construct contains 33 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:96B4074BC30E04A3|rigid:vKk4Gi3zzXxp8fYT8ChGr+3Efqg	false	sufficient binding region:1-367	sufficient binding region:1-377	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99M51	uniprotkb:B9EKI5	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	intact:EBI-682463|ensembl:ENSMUSP00000110115|ensembl:ENSMUSP00000154583	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:b9eki5_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688292	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	refseq:NP_001028410.1|refseq:XP_006522014.1|ensembl:ENSMUSG00000022637(gene)|ensembl:ENSMUST00000114471(transcript)|ensembl:ENSMUST00000227062(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023051"(regulation of signaling)|go:"GO:0047690"(aspartyltransferase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520	afcs:20358(secondary-ac)|afcs:35574(primary-reference)|afcs:7326(primary-reference)	-	comment:"AfCS Y2H protein 20358. Sequence deduced from cross-reference: protein GI: 20894431, replaced by protein GI: 51769670."|comment:"similat to rat Casitas B-lineage lymphoma b; Cbl-b protein (98%)"	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	rogid:/a/ZrHmGa1+dJMyubsxdzGfCrdQ10090	intact-crc:9D3A831264FA331B|rigid:DyprUSyzzO73EpILdLrtGHr324c	false	sufficient binding region:1-377	sufficient binding region:10-208	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35991	uniprotkb:Q60631	intact:EBI-625119|uniprotkb:Q61365|ensembl:ENSMUSP00000033617	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:btk_mouse(display_long)|uniprotkb:Bruton tyrosine kinase(gene name synonym)|uniprotkb:B-cell progenitor kinase(gene name synonym)|uniprotkb:Kinase EMB(gene name synonym)|uniprotkb:Btk(gene name)|psi-mi:Btk(display_short)|uniprotkb:Bpk(gene name synonym)|uniprotkb:Agammaglobulinemia tyrosine kinase(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652208	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035574|interpro:IPR036028|interpro:IPR036860|rcsb pdb:4XI2|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871809|reactome:R-MMU-416476|reactome:R-MMU-416482|reactome:R-MMU-5663213|reactome:R-MMU-8964315|reactome:R-MMU-983695|ensembl:ENSMUSG00000031264(gene)|ensembl:ENSMUST00000033617(transcript)|go:"GO:0001805"(positive regulation of type III hypersensitivity)|go:"GO:0001812"(positive regulation of type I hypersensitivity)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005547"(phosphatidylinositol-3,4,5-trisphosphate binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0010033"(response to organic substance)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0071226"(cellular response to molecule of fungal origin)|go:"GO:0098761"(cellular response to interleukin-7)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|refseq:NP_038510.2|refseq:XP_006528546.1|refseq:XP_006528547.1|refseq:XP_006528548.1	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:17216(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:SunADPMj2KtwnsSakRuNDqNAss410090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:B95F247183BCE7D6|rigid:KpeZ6uMd5MDk4wkGJvyIgL4gVIg	false	sufficient binding region:137-298	sufficient binding region:1-70	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6NZN1	uniprotkb:Q9QYY0	intact:EBI-644797|uniprotkb:Q3UGG3|uniprotkb:Q80TW6|uniprotkb:Q8BXP6|uniprotkb:Q91YW8|ensembl:ENSMUSP00000107530	intact:EBI-644784|uniprotkb:Q91VW7|ensembl:ENSMUSP00000034150	psi-mi:pprc1_mouse(display_long)|uniprotkb:PGC-1-related coactivator(gene name synonym)|uniprotkb:Pprc1(gene name)|psi-mi:Pprc1(display_short)|uniprotkb:Kiaa0595(gene name synonym)	psi-mi:gab1_mouse(display_long)|uniprotkb:Growth factor receptor bound protein 2-associated protein 1(gene name synonym)|uniprotkb:GRB2-associated binder 1(gene name synonym)|uniprotkb:Gab1(gene name)|psi-mi:Gab1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-652977	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074683.1|ensembl:ENSMUST00000111899(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0030374"(nuclear receptor coactivator activity)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR034597|interpro:IPR034605|interpro:IPR034834|interpro:IPR035979|ensembl:ENSMUSG00000055491(gene)|refseq:NP_001333730.1|refseq:XP_017173655.1	refseq:NP_067331.2|ensembl:ENSMUSG00000031714(gene)|ensembl:ENSMUST00000034150(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001525"(angiogenesis)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0008544"(epidermis development)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0035728"(response to hepatocyte growth factor)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0038084"(vascular endothelial growth factor signaling pathway)|go:"GO:0038089"(positive regulation of cell migration by vascular endothelial growth factor signaling pathway)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0060711"(labyrinthine layer development)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0090668"(endothelial cell chemotaxis to vascular endothelial growth factor)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR011993(Pleckstrin homology-type)|mint:Q9QYY0|reactome:R-MMU-109704|reactome:R-MMU-1257604|reactome:R-MMU-180292|reactome:R-MMU-1963642|reactome:R-MMU-5654689|reactome:R-MMU-5654695|reactome:R-MMU-5654710|reactome:R-MMU-5654720|reactome:R-MMU-6811558|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-9027276|dip:DIP-39377N	afcs:23867(primary-reference)|afcs:21362(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:wbe4I3sDNj5uVIWbwhxCVkrQkWg10090	rogid:SVtcnzm9XpYftTZ3qAV/IQgJaJE10090	intact-crc:578146CBCC98F506|rigid:zB6nWOT0UzdgcWh70ipc7um3fHU	false	sufficient binding region:?-?	sufficient binding region:1-352	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P27870	uniprotkb:Q60631	intact:EBI-1697|uniprotkb:Q8BTV7|ensembl:ENSMUSP00000005889	intact:EBI-1688|uniprotkb:Q61240|ensembl:ENSMUSP00000021090|ensembl:ENSMUSP00000102106	psi-mi:vav_mouse(display_long)|uniprotkb:Vav1(gene name)|psi-mi:Vav1(display_short)|uniprotkb:p95vav(gene name synonym)|uniprotkb:Vav(gene name synonym)	psi-mi:grb2_mouse(display_long)|uniprotkb:Grb2(gene name)|psi-mi:Grb2(display_short)|uniprotkb:Adapter protein GRB2(gene name synonym)|uniprotkb:SH2/SH3 adapter GRB2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653009	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035821.3|ensembl:ENSMUSG00000034116(gene)|ensembl:ENSMUST00000005889(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006909"(phagocytosis)|go:"GO:0006955"(immune response)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0008361"(regulation of cell size)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030593"(neutrophil chemotaxis)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042110"(T cell activation)|go:"GO:0043087"(regulation of GTPase activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045954"(positive regulation of natural killer cell mediated cytotoxicity)|dip:DIP-31010N|go:"GO:0046872"(metal ion binding)|go:"GO:0072593"(reactive oxygen species metabolic process)|go:"GO:0140031"(phosphorylation-dependent protein binding)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000980(SH2 motif)|interpro:IPR001331(Guanine-nucleotide dissociation stimulator, CDC24, conserved site)|interpro:IPR001452(Src homology-3)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR003096(SM22/calponin)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR022613|interpro:IPR028530|interpro:IPR035729|interpro:IPR035730|interpro:IPR035879|interpro:IPR035899|interpro:IPR036028|interpro:IPR036860|interpro:IPR036872|interpro:IPR037832|mint:P27870|rcsb pdb:1F5X|rcsb pdb:1GCP|rcsb pdb:1GCQ|rcsb pdb:1K1Z|rcsb pdb:2KBT|rcsb pdb:2VRW|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-389359|reactome:R-MMU-416482|reactome:R-MMU-4420097|reactome:R-MMU-512988|reactome:R-MMU-5218920|reactome:R-MMU-6811558|reactome:R-MMU-8980692|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013408|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-983695|reactome:R-MMU-1433557|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-2871809	refseq:NP_032189.1|refseq:NP_001300865.1|refseq:NP_001300866.1|dip:DIP-259N|ensembl:ENSMUSG00000059923(gene)|ensembl:ENSMUST00000021090(transcript)|ensembl:ENSMUST00000106497(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0005154"(epidermal growth factor receptor binding)|go:"GO:0005168"(neurotrophin TRKA receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007568"(aging)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031623"(receptor internalization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0042802"(identical protein binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048646"(anatomical structure formation involved in morphogenesis)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0060670"(branching involved in labyrinthine layer morphogenesis)|go:"GO:0070436"(Grb2-EGFR complex)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR035641|interpro:IPR035643|interpro:IPR036028|interpro:IPR036860|mint:Q60631|rcsb pdb:1GBQ|rcsb pdb:1GBR|rcsb pdb:2GBQ|rcsb pdb:3GBQ|rcsb pdb:4GBQ|reactome:R-MMU-109704|reactome:R-MMU-112412|reactome:R-MMU-1250347|reactome:R-MMU-1257604|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-167044|reactome:R-MMU-179812|reactome:R-MMU-180292|reactome:R-MMU-180336|reactome:R-MMU-182971|reactome:R-MMU-186763|reactome:R-MMU-1963640|reactome:R-MMU-1963642|reactome:R-MMU-2029482|reactome:R-MMU-210993|reactome:R-MMU-2179392|reactome:R-MMU-2424491|reactome:R-MMU-2428933|reactome:R-MMU-2730905|reactome:R-MMU-2871796|reactome:R-MMU-2871809|reactome:R-MMU-354194|reactome:R-MMU-375165|reactome:R-MMU-388841|reactome:R-MMU-389359|reactome:R-MMU-391160|reactome:R-MMU-5654688|reactome:R-MMU-5654689|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654699|reactome:R-MMU-5654700|reactome:R-MMU-5654704|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654719|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-6807004|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-74751|reactome:R-MMU-8851805|reactome:R-MMU-8851907|reactome:R-MMU-8853659|reactome:R-MMU-8856825|reactome:R-MMU-8856828|reactome:R-MMU-8865999|reactome:R-MMU-8875555|reactome:R-MMU-8875656|reactome:R-MMU-8983432|reactome:R-MMU-9027284|reactome:R-MMU-9028731|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9607240|reactome:R-MMU-9674555|reactome:R-MMU-983695	afcs:53767(primary-reference)|afcs:55736(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:qKKIBVHCiVoVPxnwwMqZYBZyBhA10090	rogid:0Zuj4toqaPeuo3snXLa7fckMXU410090	intact-crc:4DCF829ED84FA4CE|rigid:5Lph7Pd2MBFWGNm8AjVZTueb+RI	false	sufficient binding region:572-824	sufficient binding region:150-217	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1R2	uniprotkb:O35305	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658252	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	afcs:15472(primary-reference)|afcs:15472(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:4ACCFD8BB811F42F|rigid:dgOZHTV6TlJ5N5X4U/W50zuqnh4	false	sufficient binding region:22-390	sufficient binding region:450-621	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1R2	uniprotkb:O35305	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658263	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	afcs:15472(primary-reference)|afcs:15472(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:0FB79293196136AD|rigid:dgOZHTV6TlJ5N5X4U/W50zuqnh4	false	sufficient binding region:28-314	sufficient binding region:450-621	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1R2	uniprotkb:O35305	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658283	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	afcs:15472(primary-reference)|afcs:15472(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:1DB89316A16ACC82|rigid:dgOZHTV6TlJ5N5X4U/W50zuqnh4	false	sufficient binding region:31-266	sufficient binding region:450-621	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60803	uniprotkb:O35305	intact:EBI-520135|uniprotkb:B2RPW3|uniprotkb:Q62380|ensembl:ENSMUSP00000021706	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:traf3_mouse(display_long)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:TRAFAMN(gene name synonym)|uniprotkb:Traf3(gene name)|psi-mi:Traf3(display_short)|uniprotkb:Craf1(gene name synonym)|uniprotkb:Trafamn(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658303	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035762.2|ensembl:ENSMUSG00000021277(gene)|ensembl:ENSMUST00000021706(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q60803|rcsb pdb:4GHU|reactome:R-MMU-5668541|reactome:R-MMU-5676594|reactome:R-MMU-5689896|reactome:R-MMU-936964|refseq:XP_006515861.1|refseq:XP_006515862.1|refseq:XP_006515863.1|refseq:XP_006515864.1|dip:DIP-34050N	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	afcs:15472(primary-reference)|afcs:55740(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2MrUSSGdyGB3zrZ39xovGDK6ysE10090	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:B76959F7EE4CE827|rigid:taqsxFT2BVdIw9E5jrq8QF25/n4	false	sufficient binding region:309-567	sufficient binding region:450-621	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60803	uniprotkb:O35305	intact:EBI-520135|uniprotkb:B2RPW3|uniprotkb:Q62380|ensembl:ENSMUSP00000021706	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:traf3_mouse(display_long)|uniprotkb:CD40 receptor-associated factor 1(gene name synonym)|uniprotkb:TRAFAMN(gene name synonym)|uniprotkb:Traf3(gene name)|psi-mi:Traf3(display_short)|uniprotkb:Craf1(gene name synonym)|uniprotkb:Trafamn(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF3(gene name synonym)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658313	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035762.2|ensembl:ENSMUSG00000021277(gene)|ensembl:ENSMUST00000021706(transcript)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005768"(endosome)|go:"GO:0006915"(apoptotic process)|go:"GO:0008063"(Toll signaling pathway)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030162"(regulation of proteolysis)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032648"(regulation of interferon-beta production)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0045087"(innate immune response)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0050688"(regulation of defense response to virus)|go:"GO:0070534"(protein K63-linked ubiquitination)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027128|interpro:IPR037304|interpro:IPR043211|mint:Q60803|rcsb pdb:4GHU|reactome:R-MMU-5668541|reactome:R-MMU-5676594|reactome:R-MMU-5689896|reactome:R-MMU-936964|refseq:XP_006515861.1|refseq:XP_006515862.1|refseq:XP_006515863.1|refseq:XP_006515864.1|dip:DIP-34050N	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	afcs:15472(primary-reference)|afcs:55740(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2MrUSSGdyGB3zrZ39xovGDK6ysE10090	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:8979BF2455E848CC|rigid:taqsxFT2BVdIw9E5jrq8QF25/n4	false	sufficient binding region:321-567	sufficient binding region:450-621	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K0E1	uniprotkb:O35305	intact:EBI-647373|ensembl:ENSMUSP00000032709|ensembl:ENSMUSP00000103704|ensembl:ENSMUSP00000103705	intact:EBI-647362|uniprotkb:Q8VCT7|ensembl:ENSMUSP00000027559	psi-mi:kcd15_mouse(display_long)|uniprotkb:Kctd15(gene name)|psi-mi:Kctd15(display_short)|uniprotkb:Potassium channel tetramerization domain-containing protein 15(gene name synonym)	psi-mi:tnr11_mouse(display_long)|uniprotkb:Receptor activator of NF-KB(gene name synonym)|uniprotkb:Osteoclast differentiation factor receptor(gene name synonym)|uniprotkb:Tnfrsf11a(gene name)|psi-mi:Tnfrsf11a(display_short)|uniprotkb:Rank(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658323	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666300.1|refseq:XP_006539963.1|refseq:XP_006539964.1|refseq:XP_006539965.1|refseq:XP_006539966.1|refseq:XP_006539967.1|refseq:XP_006539968.1|ensembl:ENSMUSG00000030499(gene)|ensembl:ENSMUST00000032709(transcript)|ensembl:ENSMUST00000108069(transcript)|ensembl:ENSMUST00000108070(transcript)|go:"GO:0042802"(identical protein binding)|go:"GO:0051260"(protein homooligomerization)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR011333(BTB/POZ fold)	refseq:NP_033425.3|dip:DIP-48710N|ensembl:ENSMUSG00000026321(gene)|ensembl:ENSMUST00000027559(transcript)|go:"GO:0001503"(ossification)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004888"(transmembrane signaling receptor activity)|go:"GO:0005031"(tumor necrosis factor-activated receptor activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0009314"(response to radiation)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019955"(cytokine binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0048535"(lymph node development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0060086"(circadian temperature homeostasis)|go:"GO:0060749"(mammary gland alveolus development)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071812"(positive regulation of fever generation by positive regulation of prostaglandin secretion)|go:"GO:0071847"(TNFSF11-mediated signaling pathway)|go:"GO:0071848"(positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling)|go:"GO:0072674"(multinuclear osteoclast differentiation)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR022323|interpro:IPR022361|interpro:IPR034040|interpro:IPR041648|rcsb pdb:3ME2|rcsb pdb:3ME4|rcsb pdb:3QBQ|rcsb pdb:4GIQ|rcsb pdb:5BNQ|reactome:R-MMU-5668541|reactome:R-MMU-5676594	afcs:15472(primary-reference)|afcs:58186(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:E12xMgdhCrx8f/IgS0SqPun5vE010090	rogid:i4ywqFZctL9NJvryst9My52nv4810090	intact-crc:702C11F7FF4EB200|rigid:066sr63wKuxXu8AcDcledGv3e/I	false	sufficient binding region:151-283	sufficient binding region:450-621	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91VM5	uniprotkb:Q6PDN3	intact:EBI-647431|uniprotkb:O35479|ensembl:ENSMUSP00000048153|ensembl:ENSMUSP00000147384	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:rmxl1_mouse(display_long)|uniprotkb:Rbmxl1(gene name)|psi-mi:Rbmxl1(display_short)|uniprotkb:Heterogeneous nuclear ribonucleoprotein G-like 1(gene name synonym)|uniprotkb:RNA binding motif protein, X chromosome retrogene(gene name synonym)|uniprotkb:Rbmxrt(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658435	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006530838.1|refseq:XP_006530839.1|refseq:NP_001239018.1|refseq:NP_033059.2|ensembl:ENSMUSG00000037070(gene)|ensembl:ENSMUST00000049245(transcript)|ensembl:ENSMUST00000211719(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000791"(euchromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005681"(spliceosomal complex)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0006509"(membrane protein ectodomain proteolysis)|go:"GO:0044530"(supraspliceosomal complex)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0070062"(extracellular exosome)|go:"GO:0071013"(catalytic step 2 spliceosome)|go:"GO:0071347"(cellular response to interleukin-1)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR012604(RBM1CTR)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR035979|mint:Q91VM5	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:9148(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1aPRrfU5gcmzCimlfwuz07A4gyA10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:4559C95D85C2AE15|rigid:TVLFsngm5s/rUmF7SAwXEf+AZ04	false	sufficient binding region:95-388	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54724	uniprotkb:Q6PDN3	intact:EBI-645496|uniprotkb:Q2TAW6|ensembl:ENSMUSP00000058321	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:cavn1_mouse(display_long)|uniprotkb:Cavin1(gene name)|psi-mi:Cavin1(display_short)|uniprotkb:Cav-p60(gene name synonym)|uniprotkb:Cavin-1(gene name synonym)|uniprotkb:Polymerase I and transcript release factor(gene name synonym)|uniprotkb:Ptrf(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658446	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033012.1|dip:DIP-40506N|ensembl:ENSMUSG00000004044(gene)|ensembl:ENSMUST00000060792(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006363"(termination of RNA polymerase I transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009306"(protein secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR026752|interpro:IPR033297|mint:O54724|rcsb pdb:4QKV|reactome:R-MMU-73863|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:15128(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hPJHFyrpyl5yz+7Brojuu3W2bEA10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:FC9CEBB335B2CF25|rigid:pHeaa3GQU8lAoP5HuLOie70jqS8	false	sufficient binding region:11-190	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R0N3	uniprotkb:Q6PDN3	intact:EBI-647443|uniprotkb:Q7TQG8|ensembl:ENSMUSP00000088464|ensembl:ENSMUSP00000103129	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:syt11_mouse(display_long)|uniprotkb:Synaptotagmin XI(gene name synonym)|uniprotkb:Syt11(gene name)|psi-mi:Syt11(display_short)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658456	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_061274.2|refseq:XP_006501411.1|ensembl:ENSMUSG00000068923(gene)|ensembl:ENSMUST00000090945(transcript)|ensembl:ENSMUST00000107505(transcript)|go:"GO:0000149"(SNARE binding)|go:"GO:0001778"(plasma membrane repair)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0001891"(phagocytic cup)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005544"(calcium-dependent phospholipid binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006906"(vesicle fusion)|go:"GO:0006914"(autophagy)|go:"GO:0007612"(learning)|go:"GO:0007613"(memory)|go:"GO:0009611"(response to wounding)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0017156"(calcium-ion regulated exocytosis)|go:"GO:0017158"(regulation of calcium ion-dependent exocytosis)|go:"GO:0030276"(clathrin binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0033602"(negative regulation of dopamine secretion)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0044297"(cell body)|go:"GO:0045202"(synapse)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045806"(negative regulation of endocytosis)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048487"(beta-tubulin binding)|go:"GO:0048787"(presynaptic active zone membrane)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051650"(establishment of vesicle localization)|go:"GO:0055037"(recycling endosome)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060076"(excitatory synapse)|go:"GO:0060077"(inhibitory synapse)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:1900186"(negative regulation of clathrin-dependent endocytosis)|go:"GO:1900243"(negative regulation of synaptic vesicle endocytosis)|go:"GO:1900424"(regulation of defense response to bacterium)|go:"GO:1903979"(negative regulation of microglial cell activation)|go:"GO:1905154"(negative regulation of membrane invagination)|go:"GO:1905162"(regulation of phagosome maturation)|go:"GO:1905171"(positive regulation of protein localization to phagocytic vesicle)|go:"GO:1905469"(negative regulation of clathrin-coated pit assembly)|go:"GO:1990927"(calcium ion regulated lysosome exocytosis)|interpro:IPR000008(C2 calcium-dependent membrane targeting)|interpro:IPR001565(Synaptotagmin)|interpro:IPR028699|interpro:IPR035892|mint:Q9R0N3|reactome:R-MMU-8856825|reactome:R-MMU-8856828	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:18749(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hmxn6TCXurR8053TJ6OB1+IMiJ410090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:F9CB6C18C4627C21|rigid:jWw6cbHtKROb4YwxugRtpzGO5xM	false	sufficient binding region:67-200	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JMG9	uniprotkb:Q6PDN3	intact:EBI-647451|ensembl:ENSMUSP00000050684	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:q9jmg9_mouse(display_long)|uniprotkb:Patz1(gene name)|psi-mi:Patz1(display_short)|uniprotkb:mazr(gene name synonym)|uniprotkb:Zfp278(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658466	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062520.1|ensembl:ENSMUSG00000020453(gene)|ensembl:ENSMUST00000057089(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:19033(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:m7We0Bhp0gKP4tZJ+cLTOVGEoiI10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:8087B6734C990828|rigid:wDlOKQGiFcHriRjj+tedh+7bTB0	false	sufficient binding region:144-246	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JMG9	uniprotkb:Q6PDN3	intact:EBI-647451|ensembl:ENSMUSP00000050684	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:q9jmg9_mouse(display_long)|uniprotkb:Patz1(gene name)|psi-mi:Patz1(display_short)|uniprotkb:mazr(gene name synonym)|uniprotkb:Zfp278(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658476	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062520.1|ensembl:ENSMUSG00000020453(gene)|ensembl:ENSMUST00000057089(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:19033(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:m7We0Bhp0gKP4tZJ+cLTOVGEoiI10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:C870D2C29159C649|rigid:wDlOKQGiFcHriRjj+tedh+7bTB0	false	sufficient binding region:156-426	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JMG9	uniprotkb:Q6PDN3	intact:EBI-647451|ensembl:ENSMUSP00000050684	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:q9jmg9_mouse(display_long)|uniprotkb:Patz1(gene name)|psi-mi:Patz1(display_short)|uniprotkb:mazr(gene name synonym)|uniprotkb:Zfp278(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658486	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_062520.1|ensembl:ENSMUSG00000020453(gene)|ensembl:ENSMUST00000057089(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008584"(male gonad development)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR000637(HMG-I and HMG-Y, DNA-binding)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:19033(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:m7We0Bhp0gKP4tZJ+cLTOVGEoiI10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:B2F82C0C7655626C|rigid:wDlOKQGiFcHriRjj+tedh+7bTB0	false	sufficient binding region:178-445	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BU11	uniprotkb:Q6PDN3	intact:EBI-642377|uniprotkb:Q3UGN7|uniprotkb:Q80UI2|uniprotkb:Q99PN9|uniprotkb:Q9CS16|ensembl:ENSMUSP00000022766	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:tox4_mouse(display_long)|uniprotkb:Epidermal Langerhans cell protein LCP1(gene name synonym)|uniprotkb:Tox4(gene name)|psi-mi:Tox4(display_short)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658496	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_075923.2|ensembl:ENSMUSG00000016831(gene)|ensembl:ENSMUST00000022766(transcript)|go:"GO:0000781"(chromosome, telomeric region)|go:"GO:0000785"(chromatin)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0072357"(PTW/PP1 phosphatase complex)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|interpro:IPR037985|mint:Q8BU11	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:24561(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:kKlAMyudBIO92oXcn2QcaRHOruw10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:AE491E39B32DD856|rigid:37vYoyVmQH9gA5h9L0JEc/wIK/4	false	sufficient binding region:45-412	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99LW6	uniprotkb:Q6PDN3	intact:EBI-647461|uniprotkb:Q3UFD4|uniprotkb:Q9DBE4|ensembl:ENSMUSP00000079179	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:yaf2_mouse(display_long)|uniprotkb:Yaf2(gene name)|psi-mi:Yaf2(display_short)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658506	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_077151.3|ensembl:ENSMUSG00000022634(gene)|ensembl:ENSMUST00000080299(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR033774|interpro:IPR036443|interpro:IPR038039|interpro:IPR039958|reactome:R-MMU-8939243|reactome:R-MMU-8953750	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:24682(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0Oi4XcynspLGWIlar7RFa2g5cAs10090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:14E13C1D4510B9EB|rigid:9FsWQAb+IG46eieXPbXxh2ABgrU	false	sufficient binding region:1-179	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R081	uniprotkb:Q6PDN3	intact:EBI-647483|uniprotkb:O54789|uniprotkb:Q8K0S7|uniprotkb:Q499X2|ensembl:ENSMUSP00000049407|ensembl:ENSMUSP00000133728	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:hnrpl_mouse(display_long)|uniprotkb:Hnrpl(gene name synonym)|uniprotkb:Hnrnpl(gene name)|psi-mi:Hnrnpl(display_short)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658516	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_796275.3|refseq:XP_006539621.1|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR006536(HnRNP-L/PTB/hephaestus splicing factor)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR021790|interpro:IPR034816|interpro:IPR034817|interpro:IPR035005|interpro:IPR035008|interpro:IPR035979|mint:Q8R081|rcsb pdb:3S01|rcsb pdb:3TYT|reactome:R-MMU-72163|reactome:R-MMU-72203|go:"GO:1990715"(mRNA CDS binding)|ensembl:ENSMUSG00000015165(gene)|ensembl:ENSMUST00000038572(transcript)|ensembl:ENSMUST00000174548(transcript)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006397"(mRNA processing)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0035770"(ribonucleoprotein granule)|go:"GO:0043484"(regulation of RNA splicing)|go:"GO:0045120"(pronucleus)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0048025"(negative regulation of mRNA splicing, via spliceosome)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0097157"(pre-mRNA intronic binding)|go:"GO:1902416"(positive regulation of mRNA binding)	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:35767(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:BApt4fekoyJ285Ve13kxstcLbV010090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:7D3BE388ACF4CB5C|rigid:u+Ymy3dywmscWQynQUhHEj4KdOk	false	sufficient binding region:82-226	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9DBU5	uniprotkb:Q6PDN3	intact:EBI-647493|uniprotkb:B2RRR0|uniprotkb:Q8K565|ensembl:ENSMUSP00000067559|ensembl:ENSMUSP00000124293|ensembl:ENSMUSP00000128774	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:rnf6_mouse(display_long)|uniprotkb:Rnf6(gene name)|psi-mi:Rnf6(display_short)|uniprotkb:RLIM-like protein(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase RNF6(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658526	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_083050.1|refseq:NP_001243014.1|refseq:NP_001243016.1|ensembl:ENSMUSG00000029634(gene)|ensembl:ENSMUST00000067837(transcript)|ensembl:ENSMUST00000161859(transcript)|ensembl:ENSMUST00000169407(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016605"(PML body)|go:"GO:0030424"(axon)|go:"GO:0030517"(negative regulation of axon extension)|go:"GO:0031965"(nuclear membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044314"(protein K27-linked ubiquitination)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050681"(androgen receptor binding)|go:"GO:0060765"(regulation of androgen receptor signaling pathway)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070936"(protein K48-linked ubiquitination)|go:"GO:0085020"(protein K6-linked ubiquitination)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|reactome:R-MMU-983168	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:55692(secondary-ac)	-	-	caution:The prey construct contains 39 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:OS6gMKIgr0AdAGrQCtxoREYRl8410090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:663E58D108DACBC3|rigid:SZuLrPX5GWkgZeQULcXAOEvJgHk	false	sufficient binding region:1-331	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q80X90	uniprotkb:Q6PDN3	intact:EBI-688023|intact:EBI-777273|uniprotkb:E9QNV9|uniprotkb:Q8VHX4|uniprotkb:Q8VHX7|uniprotkb:Q99KY3|ensembl:ENSMUSP00000052020	intact:EBI-647412|uniprotkb:Q3TSJ7|uniprotkb:Q80UX0|uniprotkb:Q80YN7|uniprotkb:Q80YN8|uniprotkb:Q8K026|uniprotkb:Q924D2|uniprotkb:Q9ERD3	psi-mi:flnb_mouse(display_long)|uniprotkb:Flnb(gene name)|psi-mi:Flnb(display_short)|uniprotkb:ABP-280-like protein(gene name synonym)|uniprotkb:Actin-binding-like protein(gene name synonym)|uniprotkb:Beta-filamin(gene name synonym)	psi-mi:mylk_mouse(display_long)|uniprotkb:Telokin(gene name synonym)|uniprotkb:Kinase-related protein(gene name synonym)|uniprotkb:Mylk(gene name)|psi-mi:Mylk(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688546	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001074896.1|ensembl:ENSMUSG00000025278(gene)|ensembl:ENSMUST00000052678(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0003334"(keratinocyte development)|go:"GO:0003382"(epithelial cell morphogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005903"(brush border)|go:"GO:0005925"(focal adhesion)|go:"GO:0005938"(cell cortex)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0030018"(Z disc)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0051015"(actin filament binding)|go:"GO:0071346"(cellular response to interferon-gamma)|interpro:IPR001298(Filamin/ABP280 repeat)|interpro:IPR001589(Actinin-type, actin-binding, conserved site)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR017868|interpro:IPR029874|interpro:IPR036872|interpro:IPR044801|mint:Q80X90|reactome:R-MMU-1169408|go:"GO:0005737"(cytoplasm)	interpro:IPR015725(Myosin Light Chain Kinase)|interpro:IPR003961(Fibronectin, type III)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR013098(Immunoglobulin I-set)|interpro:IPR003599(Immunoglobulin subtype)|interpro:IPR003598(Immunoglobulin subtype 2)|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|mint:Q6PDN3|interpro:IPR036116|interpro:IPR036179|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071476"(cellular hypotonic response)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0060414"(aorta smooth muscle tissue morphogenesis)|reactome:R-MMU-445355|reactome:R-MMU-5627123|go:"GO:0001725"(stress fiber)|go:"GO:0003779"(actin binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004687"(myosin light chain kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006939"(smooth muscle contraction)|go:"GO:0014820"(tonic smooth muscle contraction)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032060"(bleb assembly)|go:"GO:0032154"(cleavage furrow)|go:"GO:0035690"|go:"GO:0035865"(cellular response to potassium ion)|go:"GO:0046872"(metal ion binding)|go:"GO:0051928"(positive regulation of calcium ion transport)	afcs:35660(primary-reference)|afcs:55100(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:A5bnyO/GwzIgn56NbxZGMkAWYk410090	rogid:jWLQayynUVwCHoaUn27vnHB45/o10090	intact-crc:190FFF0B7946FA4B|rigid:2F+UxPXz4FqXmjrCFwnLb93vtQk	false	sufficient binding region:435-969	sufficient binding region:500-800	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648565	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	caution:The prey construct contains 9 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:65F4B223FC5C6A4D|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:1-293	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648588	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	caution:The prey construct contains 2 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:DE819146FF687A27|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:1-206	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648599	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:94DB13AEA454CE94|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:5-172	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648609	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:9BEB45E6115B9D01|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:17-208	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648619	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:FF7AD7F8455112C7|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:19-189	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648629	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:BCE4BBDA14ED3007|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:21-293	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648639	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:D69F98187B69B395|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:26-127	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648649	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:E74F3A7B08C5CECE|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:26-208	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648659	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:F7DD4EA52D6A7510|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:35-226	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648669	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:5B12F83E911A8338|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:46-218	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64337	uniprotkb:Q9WVS7	intact:EBI-645025|uniprotkb:Q99JM8|ensembl:ENSMUSP00000099835	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:sqstm_mouse(display_long)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:STONE14(gene name synonym)|uniprotkb:Sqstm1(gene name)|psi-mi:Sqstm1(display_short)|uniprotkb:A170(gene name synonym)|uniprotkb:STAP(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653524	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277698.1|refseq:NP_035148.1|ensembl:ENSMUSG00000015837(gene)|ensembl:ENSMUST00000102774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033741|interpro:IPR034866|interpro:IPR043145|mint:Q64337|rcsb pdb:2RRU|rcsb pdb:2ZJD|rcsb pdb:3ADE|rcsb pdb:3B0F|rcsb pdb:3WDZ|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-5205685|reactome:R-MMU-9020702|reactome:R-MMU-9664873|dip:DIP-38490N	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:16512(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/BktZPkmiLsU1fKVqPSQ8ae2+SY10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:73C1E86C48C8298E|rigid:En2oBm2XyRSl3RyGD228hwVam84	false	sufficient binding region:2-442	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653574	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:8137EFF4FE171A1D|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:35-320	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653594	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:4294AD4BA1E95571|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:92-321	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653604	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:7B7AF40466A6F422|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:112-304	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653614	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:124913AA74E41AD2|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:131-322	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653634	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:19F4A751E4839ECE|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:160-391	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653644	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:E75100B10E52D3BE|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:162-320	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653664	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:654304C227957297|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:174-363	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653674	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:951B7D2751ECEB47|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:178-358	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653684	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:09726CAE66717D3D|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:178-375	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653694	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:F94E184019F18259|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:178-391	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653724	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:3144F7088339B56E|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:181-324	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653734	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:F2CFB751E2ABF5BD|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:181-346	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653744	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:9B4F664157D17682|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:205-358	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653754	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:C6D871603DC9487B|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:255-391	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WUI1	uniprotkb:P47811	intact:EBI-645081|uniprotkb:Q569F1|ensembl:ENSMUSP00000086204	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk11_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase p38 beta(gene name synonym)|uniprotkb:Mapk11(gene name)|psi-mi:Mapk11(display_short)|uniprotkb:Prkm11(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653865	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035291.4|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6804756|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000053137(gene)|ensembl:ENSMUST00000088823(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:16597(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T7B5ln4XE1gB3AwhK0A48i+Ne4Q10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:A6BE80F42090C7A8|rigid:YePgabS6/cCWGNkXfUwhh282msw	false	sufficient binding region:151-364	sufficient binding region:2-160	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P47811	uniprotkb:Q9WUI1	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	intact:EBI-645081|uniprotkb:Q569F1|ensembl:ENSMUSP00000086204	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:mk11_mouse(display_long)|uniprotkb:Mitogen-activated protein kinase p38 beta(gene name synonym)|uniprotkb:Mapk11(gene name)|psi-mi:Mapk11(display_short)|uniprotkb:Prkm11(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653876	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	refseq:NP_035291.4|go:"GO:0006468"(protein phosphorylation)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060043"(regulation of cardiac muscle cell proliferation)|go:"GO:0060044"(negative regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0098586"(cellular response to virus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6804756|go:"GO:0005829"(cytosol)|ensembl:ENSMUSG00000053137(gene)|ensembl:ENSMUST00000088823(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)	afcs:17113(primary-reference)|afcs:16597(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	rogid:T7B5ln4XE1gB3AwhK0A48i+Ne4Q10090	intact-crc:482048193DEAE72D|rigid:YePgabS6/cCWGNkXfUwhh282msw	false	sufficient binding region:2-160	sufficient binding region:250-364	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P35922	uniprotkb:P26323	intact:EBI-645094	intact:EBI-645152|ensembl:ENSMUSP00000016231	psi-mi:fmr1_mouse(display_long)|uniprotkb:Fmr1(gene name)|psi-mi:Fmr1(display_short)|uniprotkb:Fmr-1(gene name synonym)|uniprotkb:Fragile X mental retardation protein 1 homolog(gene name synonym)	psi-mi:fli1_mouse(display_long)|uniprotkb:Retroviral integration site protein Fli-1(gene name synonym)|uniprotkb:Fli1(gene name)|psi-mi:Fli1(display_short)|uniprotkb:Fli-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653886	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR008395(Agenet)|interpro:IPR022034|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032196|interpro:IPR040472|go:"GO:0000340"(RNA 7-methylguanosine cap binding)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0000775"(chromosome, centromeric region)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002091"(negative regulation of receptor internalization)|go:"GO:0002092"(positive regulation of receptor internalization)|go:"GO:0002151"(G-quadruplex RNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015030"(Cajal body)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030371"(translation repressor activity)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031047"(gene silencing by RNA)|go:"GO:0031369"(translation initiation factor binding)|go:"GO:0032433"(filopodium tip)|go:"GO:0033129"(positive regulation of histone phosphorylation)|go:"GO:0033592"(RNA strand annealing activity)|go:"GO:0034046"("poly(G) binding")|go:"GO:0034644"(cellular response to UV)|go:"GO:0035064"(methylated histone binding)|go:"GO:0035197"(siRNA binding)|go:"GO:0035198"(miRNA binding)|go:"GO:0035613"(RNA stem-loop binding)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043195"(terminal bouton)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043488"(regulation of mRNA stability)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043679"(axon terminus)|go:"GO:0003723"(RNA binding)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:1990825"(sequence-specific mRNA binding)|go:"GO:1990904"(ribonucleoprotein complex)|go:"GO:2000301"(negative regulation of synaptic vesicle exocytosis)|go:"GO:2000766"(negative regulation of cytoplasmic translation)|go:"GO:2001022"(positive regulation of response to DNA damage stimulus)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044326"(dendritic spine neck)|go:"GO:0044327"(dendritic spine head)|go:"GO:0044830"(modulation by host of viral RNA genome replication)|go:"GO:0045182"(translation regulator activity)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045947"(negative regulation of translational initiation)|go:"GO:0046928"(regulation of neurotransmitter secretion)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048027"(mRNA 5'-UTR binding)|go:"GO:0048170"(positive regulation of long-term neuronal synaptic plasticity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051028"(mRNA transport)|go:"GO:0051489"(regulation of filopodium assembly)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0060964"(regulation of gene silencing by miRNA)|go:"GO:0060996"(dendritic spine development)|go:"GO:0060998"(regulation of dendritic spine development)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0070840"(dynein complex binding)|go:"GO:0071598"(neuronal ribonucleoprotein granule)|go:"GO:0072711"(cellular response to hydroxyurea)|go:"GO:0097386"(glial cell projection)|go:"GO:0097444"(spine apparatus)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098793"(presynapse)|go:"GO:0098794"(postsynapse)|go:"GO:0098908"(regulation of neuronal action potential)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099523"(presynaptic cytosol)|go:"GO:0099524"(postsynaptic cytosol)|go:"GO:0099577"(regulation of translation at presynapse, modulating synaptic transmission)|go:"GO:0099578"(regulation of translation at postsynapse, modulating synaptic transmission)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1900453"(negative regulation of long-term synaptic depression)|go:"GO:1900454"(positive regulation of long-term synaptic depression)|go:"GO:1901254"(positive regulation of intracellular transport of viral material)|go:"GO:1901386"(negative regulation of voltage-gated calcium channel activity)|go:"GO:1901800"(positive regulation of proteasomal protein catabolic process)|go:"GO:1902373"(negative regulation of mRNA catabolic process)|go:"GO:1902416"(positive regulation of mRNA binding)|go:"GO:1902737"(dendritic filopodium)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905244"(regulation of modification of synaptic structure)|go:"GO:1990124"(messenger ribonucleoprotein complex)|go:"GO:1990635"(proximal dendrite)|go:"GO:1990812"(growth cone filopodium)|go:"GO:0044297"(cell body)|go:"GO:0003730"(mRNA 3'-UTR binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005844"(polysome)|go:"GO:0005845"(mRNA cap binding complex)|go:"GO:0003729"(mRNA binding)|go:"GO:0006397"(mRNA processing)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007215"(glutamate receptor signaling pathway)|go:"GO:0007417"(central nervous system development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0008380"(RNA splicing)|go:"GO:0010369"(chromocenter)|go:"GO:0010494"(cytoplasmic stress granule)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010955"(negative regulation of protein processing)|mint:P35922|interpro:IPR036612|interpro:IPR040148|interpro:IPR041560	refseq:NP_032052.1|ensembl:ENSMUSG00000016087(gene)|ensembl:ENSMUST00000016231(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008015"(blood circulation)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009987"(cellular process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR000418(Ets)|go:"GO:0016604"(nuclear body)|interpro:IPR003118(Sterile alpha motif/pointed)|interpro:IPR013761(Sterile alpha motif-type)|go:"GO:0030154"(cell differentiation)|interpro:IPR035573|interpro:IPR035575|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|interpro:IPR036388|interpro:IPR036390	afcs:14342(primary-reference)|afcs:14337(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/NR92KtQt5zwsa+U6lel3sXQyu810090	rogid:auNSYuPCwW44fXwHIT9bVmYpwYc10090	intact-crc:5F8558E7C555DE8E|rigid:aHokX0r+ZFeiJxMAJ4M7t+gDLw8	false	sufficient binding region:1-125	sufficient binding region:24-150	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYB1	uniprotkb:P70181	intact:EBI-645175|uniprotkb:Q8BMG5|ensembl:ENSMUSP00000041453	intact:EBI-645167|uniprotkb:O70335|uniprotkb:Q8JZY6|ensembl:ENSMUSP00000025800	psi-mi:clic4_mouse(display_long)|uniprotkb:Clic4(gene name)|psi-mi:Clic4(display_short)	psi-mi:pi51b_mouse(display_long)|uniprotkb:Pip5k1b(gene name)|psi-mi:Pip5k1b(display_short)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I beta(gene name synonym)|uniprotkb:68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653918	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038913.1|ensembl:ENSMUSG00000037242(gene)|ensembl:ENSMUST00000037099(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006821"(chloride transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002946(Intracellular chloride channel)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR030257|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:Q9QYB1	refseq:NP_032872.1|refseq:XP_006526826.1|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|reactome:R-MMU-1660499|reactome:R-MMU-201688|reactome:R-MMU-6811558|ensembl:ENSMUSG00000024867(gene)|ensembl:ENSMUST00000025800(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)	afcs:15015(primary-reference)|afcs:17522(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ghFdQmcUo1BuprnYT0mQRKnjgcw10090	rogid:heOUYCsDnkVH7SY/9uX3eoH0d+k10090	intact-crc:8B17EF2BAC88D8A9|rigid:hMkRHw6cBF2ee14irdYJVjx39r4	false	sufficient binding region:74-253	sufficient binding region:350-500	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1Q5	uniprotkb:P70181	intact:EBI-645184|ensembl:ENSMUSP00000007257	intact:EBI-645167|uniprotkb:O70335|uniprotkb:Q8JZY6|ensembl:ENSMUSP00000025800	psi-mi:clic1_mouse(display_long)|uniprotkb:Nuclear chloride ion channel 27(gene name synonym)|uniprotkb:Clic1(gene name)|psi-mi:Clic1(display_short)	psi-mi:pi51b_mouse(display_long)|uniprotkb:Pip5k1b(gene name)|psi-mi:Pip5k1b(display_short)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I beta(gene name synonym)|uniprotkb:68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653948	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_254279.1|ensembl:ENSMUSG00000007041(gene)|ensembl:ENSMUST00000007257(transcript)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0006749"(glutathione metabolic process)|go:"GO:0006821"(chloride transport)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051881"(regulation of mitochondrial membrane potential)|go:"GO:0070062"(extracellular exosome)|interpro:IPR002946(Intracellular chloride channel)|interpro:IPR004045(Glutathione S-transferase, N-terminal)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR030259|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:Q9Z1Q5|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005886"(plasma membrane)	refseq:NP_032872.1|refseq:XP_006526826.1|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|reactome:R-MMU-1660499|reactome:R-MMU-201688|reactome:R-MMU-6811558|ensembl:ENSMUSG00000024867(gene)|ensembl:ENSMUST00000025800(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)	afcs:15015(primary-reference)|afcs:40286(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jYlg790vEs26tJ+6hGzV2KEGFQM10090	rogid:heOUYCsDnkVH7SY/9uX3eoH0d+k10090	intact-crc:67B0F4E40E414522|rigid:HODvfMRR0Huc1VAmznvBRK6pjFQ	false	sufficient binding region:97-241	sufficient binding region:350-500	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-684233	uniprotkb:Q9WVS7	afcs:40254	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:big1_mouse_protein(display_short)|psi-mi:EBI-684233(display_long)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688369	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:40254(secondary-ac)|afcs:17026(primary-reference)|afcs:40254(primary-reference)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:ADP-ribosylation factor guanine nucleotide-exchange factor 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; BIG1; P200; ARFGEP1; D130059B05Rik; D730028O18Rik|comment:"AfCS Y2H protein 40254. Sequence translated from nucleotide sequence and the full-length was deduced from the cross-reference Protein GI: 51704830."|comment:"similar to human BIG1 (97%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QACpRgUhkx50zGB4gpb2zZezcx810090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:6A12F0770C913CE2|rigid:lQ9x269dbTU1aMXWTFE3ZDmWsGA	false	sufficient binding region:1454-1646	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C2B3	uniprotkb:Q8CFN5-4	intact:EBI-643830|uniprotkb:Q8C2C9|uniprotkb:Q8C8X4|uniprotkb:Q8CB80|uniprotkb:Q8CDA3|uniprotkb:Q9JL72|ensembl:ENSMUSP00000085744	intact:EBI-643822|ensembl:ENSMUSP00000143742	psi-mi:hdac7_mouse(display_long)|uniprotkb:Histone deacetylase 7A(gene name synonym)|uniprotkb:Hdac7(gene name)|psi-mi:Hdac7(display_short)|uniprotkb:Hdac7a(gene name synonym)	psi-mi:q8cfn5-4(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651467	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001191204.1|refseq:NP_001191205.1|refseq:NP_001191206.1|refseq:NP_001191207.1|refseq:NP_062518.2|ensembl:ENSMUSG00000022475|ensembl:ENSMUSG00000022475(gene)|ensembl:ENSMUST00000088402(transcript)|go:"GO:0000118"(histone deacetylase complex)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001570"(vasculogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0004407"(histone deacetylase activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006476"(protein deacetylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0007043"(cell-cell junction assembly)|go:"GO:0007399"(nervous system development)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030183"(B cell differentiation)|go:"GO:0032041"("NAD-dependent histone deacetylase activity (H3-K14 specific)")|go:"GO:0032703"(negative regulation of interleukin-2 production)|go:"GO:0033558"(protein deacetylase activity)|go:"GO:0042113"(B cell activation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045843"(negative regulation of striated muscle tissue development)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0071889"(14-3-3 protein binding)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1901223"(negative regulation of NIK/NF-kappaB signaling)|interpro:IPR000286(Histone deacetylase superfamily)|interpro:IPR017320(Histone deacetylase class II, eukaryotic)|interpro:IPR023696|interpro:IPR023801|interpro:IPR033660|interpro:IPR037138|mint:Q8C2B3|reactome:R-MMU-3108214|reactome:R-MMU-350054|go:"GO:0006325"(chromatin organization)|refseq:XP_006521268.1|refseq:XP_006521270.1|refseq:XP_006521271.1|refseq:XP_006521272.1|refseq:XP_006521273.1|dip:DIP-42594N	intact:EBI-643797(mef2c_mouse)|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000198199(transcript)	afcs:7289(primary-reference)|afcs:11900(secondary-ac)	-	isoform-comment:Contains a phosphothreonine at position 108.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ndT8bcA7GrstuJrxHqbakZwEg0Q10090	rogid:1ZAceE7Fb8MF58fpsYpHgRfA+pM10090	intact-crc:526E079D18E59E9E|rigid:Yah2xtwWJ96mhURhW+kQB1ITlKo	false	sufficient binding region:61-341	sufficient binding region:1-200	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1Y4	uniprotkb:Q8CFN5-4	intact:EBI-643879|uniprotkb:Q3TX74|ensembl:ENSMUSP00000024119	intact:EBI-643822|ensembl:ENSMUSP00000143742	psi-mi:trip6_mouse(display_long)|uniprotkb:Zyxin-related protein 1(gene name synonym)|uniprotkb:Trip6(gene name)|psi-mi:Trip6(display_short)|uniprotkb:Zrp1(gene name synonym)	psi-mi:q8cfn5-4(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651478	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035769.1|ensembl:ENSMUSG00000023348(gene)|ensembl:ENSMUST00000024119(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q9Z1Y4	intact:EBI-643797(mef2c_mouse)|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000198199(transcript)	afcs:7289(primary-reference)|afcs:16891(secondary-ac)	-	isoform-comment:Contains a phosphothreonine at position 108.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:7eIRYOt0EYhXcPOpabbr1GUYO0g10090	rogid:1ZAceE7Fb8MF58fpsYpHgRfA+pM10090	intact-crc:195072392D617F08|rigid:ucvV9EoRmux76gdgC0nk1dkUIAA	false	sufficient binding region:252-480	sufficient binding region:60-260	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CFN5-4	uniprotkb:Q9Z1Y4	intact:EBI-643822|ensembl:ENSMUSP00000143742	intact:EBI-643879|uniprotkb:Q3TX74|ensembl:ENSMUSP00000024119	psi-mi:q8cfn5-4(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:trip6_mouse(display_long)|uniprotkb:Zyxin-related protein 1(gene name synonym)|uniprotkb:Trip6(gene name)|psi-mi:Trip6(display_short)|uniprotkb:Zrp1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651489	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-643797(mef2c_mouse)|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000198199(transcript)	refseq:NP_035769.1|ensembl:ENSMUSG00000023348(gene)|ensembl:ENSMUST00000024119(transcript)|go:"GO:0001725"(stress fiber)|go:"GO:0005149"(interleukin-1 receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007165"(signal transduction)|go:"GO:0019900"(kinase binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0043009"(chordate embryonic development)|go:"GO:0046872"(metal ion binding)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|interpro:IPR001781(Zinc finger, LIM-type)|mint:Q9Z1Y4	afcs:7289(primary-reference)|afcs:16891(secondary-ac)	isoform-comment:Contains a phosphothreonine at position 108.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:1ZAceE7Fb8MF58fpsYpHgRfA+pM10090	rogid:7eIRYOt0EYhXcPOpabbr1GUYO0g10090	intact-crc:A4D2B6D522B5F2F5|rigid:ucvV9EoRmux76gdgC0nk1dkUIAA	false	sufficient binding region:60-260	sufficient binding region:310-480	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P49025-1	uniprotkb:Q8CFN5-4	intact:EBI-487861	intact:EBI-643822|ensembl:ENSMUSP00000143742	psi-mi:p49025-1(display_long)|uniprotkb:CRIK(isoform synonym)|uniprotkb:Cit(gene name)|psi-mi:Cit(display_short)|uniprotkb:Rho-interacting, serine/threonine-protein kinase 21(gene name synonym)|uniprotkb:Crik(gene name synonym)	psi-mi:q8cfn5-4(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651499	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-397301(ctro_mouse)	intact:EBI-643797(mef2c_mouse)|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000198199(transcript)	afcs:7289(primary-reference)|afcs:9354(secondary-ac)	-	isoform-comment:Contains a phosphothreonine at position 108.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8kykadVIiyk12GjGCZNn0bQ13C010090	rogid:1ZAceE7Fb8MF58fpsYpHgRfA+pM10090	intact-crc:15D5AACA4C131E65|rigid:FtDCpIyZ6YkPYhsQ+NpXzPj8GFs	false	sufficient binding region:1620-2055	sufficient binding region:250-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99K48-1	uniprotkb:P63001	intact:EBI-607507|ensembl:ENSMUSP00000033673	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:q99k48-1(display_long)|uniprotkb:Nono(gene name)|psi-mi:Nono(display_short)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651510	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031311(gene)|ensembl:ENSMUST00000033673(transcript)|intact:EBI-607499(nono_mouse)	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	afcs:23265(primary-reference)|afcs:24473(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:78ly3/4yzdfLjl9d/cV6Ob/SFG810090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:83CF93C6849B8AE1|rigid:6kNWzJut6gBE8gQlHIikKlhw4CE	false	sufficient binding region:166-381	sufficient binding region:50-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99K48-1	uniprotkb:P63001	intact:EBI-607507|ensembl:ENSMUSP00000033673	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:q99k48-1(display_long)|uniprotkb:Nono(gene name)|psi-mi:Nono(display_short)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651521	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000031311(gene)|ensembl:ENSMUST00000033673(transcript)|intact:EBI-607499(nono_mouse)	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	afcs:23265(primary-reference)|afcs:24473(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:78ly3/4yzdfLjl9d/cV6Ob/SFG810090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:411B43E6623818E8|rigid:6kNWzJut6gBE8gQlHIikKlhw4CE	false	sufficient binding region:199-347	sufficient binding region:50-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O70318	uniprotkb:P63001	intact:EBI-643339|uniprotkb:G3X9B8|ensembl:ENSMUSP00000055122|ensembl:ENSMUSP00000090314	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:e41l2_mouse(display_long)|uniprotkb:Generally expressed protein 4.1(gene name synonym)|uniprotkb:Epb41l2(gene name)|psi-mi:Epb41l2(display_short)|uniprotkb:Epb4.1l2(gene name synonym)|uniprotkb:Erythrocyte membrane protein band 4.1-like 2(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651531	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038539.2|refseq:NP_001186194.1|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007049"(cell cycle)|go:"GO:0008180"(COP9 signalosome)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0005654"(nucleoplasm)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030054"(cell junction)|go:"GO:0030507"(spectrin binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031032"(actomyosin structure organization)|go:"GO:0042731"(PH domain binding)|go:"GO:0051301"(cell division)|go:"GO:0099738"(cell cortex region)|go:"GO:1904778"(positive regulation of protein localization to cell cortex)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000798(Ezrin/radixin/moesin ERM)|interpro:IPR007477(SAB)|interpro:IPR008379(Band 4.1, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR014847("FERM adjacent (FA)")|interpro:IPR018979|interpro:IPR018980|interpro:IPR019747|interpro:IPR019748|interpro:IPR019749|interpro:IPR029071|interpro:IPR030546|interpro:IPR035963|mint:O70318|reactome:R-MMU-6794361|ensembl:ENSMUSG00000019978(gene)|ensembl:ENSMUST00000053748(transcript)|ensembl:ENSMUST00000092645(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	afcs:23265(primary-reference)|afcs:34668(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4hNttT3WQk43puSMmOdjpNS8oUo10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:24322C5869F5F6D2|rigid:hPewzClEIxeey6qT6HFTpuJwUrY	false	sufficient binding region:799-987	sufficient binding region:50-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97366	uniprotkb:P63001	intact:EBI-643888|uniprotkb:Q3TPQ1	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:evi5_mouse(display_long)|uniprotkb:Evi5(gene name)|psi-mi:Evi5(display_short)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651541	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR000195(RabGAP/TBC)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0007049"(cell cycle)|go:"GO:0031267"(small GTPase binding)|go:"GO:0042147"(retrograde transport, endosome to Golgi)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0051301"(cell division)|go:"GO:0090630"(activation of GTPase activity)|interpro:IPR031214|interpro:IPR035969	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	afcs:23265(primary-reference)|afcs:14285(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4oBWLmyLLxPgj0MJR3v3qjNYLEQ10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:0AD7F55D32D7F8E9|rigid:RytrsRI7sOZrCcBMUd0fcV9GQoE	false	sufficient binding region:559-809	sufficient binding region:50-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CG19	uniprotkb:P63001	intact:EBI-643893|uniprotkb:O88349|uniprotkb:Q8BNW7|uniprotkb:Q8C7F5|uniprotkb:Q8CIR0|uniprotkb:B1B1D9|uniprotkb:B1B1E1|uniprotkb:Q505C9|uniprotkb:Q8CG18|ensembl:ENSMUSP00000001927	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:ltbp1_mouse(display_long)|uniprotkb:Transforming growth factor beta-1-binding protein 1(gene name synonym)|uniprotkb:Ltbp1(gene name)|psi-mi:Ltbp1(display_short)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651551	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064303.2|refseq:NP_996841.1|ensembl:ENSMUST00000001927(transcript)|go:"GO:0001527"(microfibril)|go:"GO:0003281"(ventricular septum development)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005576"(extracellular region)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0030425"(dendrite)|go:"GO:0031012"(extracellular matrix)|go:"GO:0032967"(positive regulation of collagen biosynthetic process)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035583"(sequestering of TGFbeta in extracellular matrix)|go:"GO:0035904"(aorta development)|go:"GO:0038045"(large latent transforming growth factor-beta complex)|go:"GO:0043025"(neuronal cell body)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050431"(transforming growth factor beta binding)|go:"GO:0050436"(microfibril binding)|ensembl:ENSMUSG00000001870(gene)|go:"GO:0060976"(coronary vasculature development)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:1901388"(regulation of transforming growth factor beta activation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR017878|interpro:IPR018097|interpro:IPR026823|interpro:IPR036773|reactome:R-MMU-2129379|reactome:R-MMU-381426|reactome:R-MMU-8957275|refseq:NP_001318166.1	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	afcs:23265(primary-reference)|afcs:18363(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:6UWbo7DbOLmgtGoQ0zgAicqdBts10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:76ACA17089A2FC15|rigid:2xY0hI1D9OzloyWHwhNkt6btklY	false	sufficient binding region:830-1157	sufficient binding region:50-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:E9PW05	uniprotkb:O88643	intact:EBI-643920|ensembl:ENSMUSP00000007884|ensembl:ENSMUSP00000132983|uniprotkb:O88631|uniprotkb:Q66JT2|uniprotkb:Q6R5P4	intact:EBI-457240	psi-mi:zfp54_mouse(display_long)|uniprotkb:Zfp54(gene name)|psi-mi:Zfp54(display_short)|uniprotkb:Krueppel-associated box protein 10(gene name synonym)	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651561	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000023882(gene)|ensembl:ENSMUST00000007884(transcript)|ensembl:ENSMUST00000165230(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR001909(Krueppel-associated  box)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036051|interpro:IPR036236|refseq:NP_035890.2	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	afcs:16524(primary-reference)|afcs:16963(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2019/01/23	rogid:iKaReRJvtc92dPSv2Hbs2/PCtgU10090	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	intact-crc:80BA03068B8A8165|rigid:IJD6NHbcGqPqprlni6SdsrhlkiQ	false	sufficient binding region:44-142	sufficient binding region:150-401	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88665	uniprotkb:O08908	intact:EBI-643930|uniprotkb:Q3UQ56|uniprotkb:Q3UU06|uniprotkb:Q9CT78|ensembl:ENSMUSP00000034085	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:brd7_mouse(display_long)|uniprotkb:75 kDa bromodomain protein(gene name synonym)|uniprotkb:Brd7(gene name)|psi-mi:Brd7(display_short)|uniprotkb:Bp75(gene name synonym)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651582	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036177.1|ensembl:ENSMUSG00000031660(gene)|ensembl:ENSMUST00000034085(transcript)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0002039"(p53 binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007049"(cell cycle)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0042393"(histone binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0070577"(lysine-acetylated histone binding)|go:"GO:2000134"(negative regulation of G1/S transition of mitotic cell cycle)|interpro:IPR001487(Bromodomain)|interpro:IPR021900|interpro:IPR036427|mint:O88665|reactome:R-MMU-6804758|refseq:XP_017168329.1	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:17179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:TehDHB6PCW5X591xzodcZrNQbHY10090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:0AB901395A460A9D|rigid:1FBhY6eBXGI3TUXgmerzWs1aXe0	false	sufficient binding region:402-651	sufficient binding region:397-624	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P08207	uniprotkb:O08908	intact:EBI-643986|ensembl:ENSMUSP00000036949|ensembl:ENSMUSP00000130712	intact:EBI-643570|ensembl:ENSMUSP00000034296|uniprotkb:Q5U3K7	psi-mi:s10aa_mouse(display_long)|uniprotkb:S100 calcium-binding protein A10(gene name synonym)|uniprotkb:Calpactin-1 light chain(gene name synonym)|uniprotkb:Calpactin I light chain(gene name synonym)|uniprotkb:p10 protein(gene name synonym)|uniprotkb:p11(gene name synonym)|uniprotkb:Cellular ligand of annexin II(gene name synonym)|uniprotkb:S100a10(gene name)|psi-mi:S100a10(display_short)|uniprotkb:Cal1l(gene name synonym)	psi-mi:p85b_mouse(display_long)|uniprotkb:Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta(gene name synonym)|uniprotkb:Pik3r2(gene name)|psi-mi:Pik3r2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651644	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033138.1|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990665"(AnxA2-p11 complex)|interpro:IPR001751(S100/CaBP-9k-type, calcium binding)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR013787(S100/CaBP-9k-type, calcium binding, subdomain)|interpro:IPR028476|mint:P08207|reactome:R-MMU-75205|go:"GO:0072659"(protein localization to plasma membrane)|ensembl:ENSMUSG00000041959(gene)|ensembl:ENSMUST00000045756(transcript)|ensembl:ENSMUST00000170612(transcript)|go:"GO:0001765"(membrane raft assembly)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006900"(vesicle budding from membrane)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0042493"|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0045121"(membrane raft)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0051099"(positive regulation of binding)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0062023"(collagen-containing extracellular matrix)	ensembl:ENSMUSG00000031834(gene)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034976"(response to endoplasmic reticulum stress)|ensembl:ENSMUST00000034296(transcript)|go:"GO:0036312"(phosphatidylinositol 3-kinase regulatory subunit binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0001678"(cellular glucose homeostasis)|go:"GO:0043409"(negative regulation of MAPK cascade)|go:"GO:0043551"(regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|go:"GO:0046935"(1-phosphatidylinositol-3-kinase regulator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005925"(focal adhesion)|go:"GO:0005942"(phosphatidylinositol 3-kinase complex)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010506"(regulation of autophagy)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0015031"(protein transport)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030833"(regulation of actin filament polymerization)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0030971"(receptor tyrosine kinase binding)|refseq:NP_032867.2|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:1903076"(regulation of protein localization to plasma membrane)|interpro:IPR000198(RhoGAP)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR008936(Rho GTPase activation protein)|interpro:IPR032498|interpro:IPR035020|interpro:IPR035022|interpro:IPR035586|interpro:IPR036028|interpro:IPR036860|rcsb pdb:2Y3A|reactome:R-MMU-109704|reactome:R-MMU-112399|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-1660499|reactome:R-MMU-186763|reactome:R-MMU-198203|reactome:R-MMU-202424|reactome:R-MMU-2029485|reactome:R-MMU-210993|reactome:R-MMU-2424491|reactome:R-MMU-2730905|reactome:R-MMU-388841|reactome:R-MMU-389357|reactome:R-MMU-416476|reactome:R-MMU-4420097|reactome:R-MMU-6811558|reactome:R-MMU-512988|reactome:R-MMU-8853659|reactome:R-MMU-8980692|reactome:R-MMU-9009391|reactome:R-MMU-9013026|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013405|reactome:R-MMU-9013409|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9035034|reactome:R-MMU-912526|reactome:R-MMU-912631|reactome:R-MMU-9696264|reactome:R-MMU-5673001|reactome:R-MMU-9696270|reactome:R-MMU-9696273	afcs:52682(primary-reference)|afcs:52666(secondary-ac)	-	-	caution:The prey construct contains 5 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZMDpz9SmMc3cQ195GiMFbhaCuR410090	rogid:8SNYg9Yr1SPNGhxsho1rANQT/Ks10090	intact-crc:C83746F88687A57E|rigid:iYx7oR8HxJHytphMRNtzSdKvhTk	false	sufficient binding region:2-97	sufficient binding region:497-722	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-644013	uniprotkb:P63001	-	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:q99l76_mouse(display_short)|psi-mi:EBI-644013(display_long)|uniprotkb:Prpf4b(gene name)|psi-mi:Prpf4b(display_short)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651664	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	uniprotkb:Q99L76(uniprot-removed-ac)	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	afcs:23265(primary-reference)|afcs:35255(secondary-ac)	no-uniprot-update:|caution:The sequence has been withdrawn from uniprot.	-	caution:The prey construct contains 8 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Pb9f+9RPEjVkXoiihOJtGkUBvE810090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:9D4C5C3E45B5AC9C|rigid:A5nRqUDcPt2mLtfL9zO7TM7O85Q	false	sufficient binding region:1-194	sufficient binding region:50-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8R0T2	uniprotkb:O88643	intact:EBI-644020|ensembl:ENSMUSP00000055374	intact:EBI-457240	psi-mi:zn768_mouse(display_long)|uniprotkb:Znf768(gene name)|psi-mi:Znf768(display_short)|uniprotkb:Zfp768(gene name synonym)	psi-mi:pak1_mouse(display_long)|uniprotkb:p21-activated kinase 1(gene name synonym)|uniprotkb:p65-PAK(gene name synonym)|uniprotkb:Alpha-PAK(gene name synonym)|uniprotkb:CDC42/RAC effector kinase PAK-A(gene name synonym)|uniprotkb:Pak1(gene name)|psi-mi:Pak1(display_short)|uniprotkb:Paka(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651674	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_666314.1|reactome:R-MMU-212436|ensembl:ENSMUST00000060783(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|interpro:IPR000684(RNA polymerase II, heptapeptide repeat, eukaryotic)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|ensembl:ENSMUSG00000047371(gene)	go:"GO:0001666"(response to hypoxia)|go:"GO:0001726"(ruffle)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005518"(collagen binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006887"(exocytosis)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007528"(neuromuscular junction development)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010033"(response to organic substance)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016310"(phosphorylation)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0019226"(transmission of nerve impulse)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021764"(amygdala development)|go:"GO:0030010"(establishment of cell polarity)|go:"GO:0030018"(Z disc)|go:"GO:0030027"(lamellipodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0030426"(growth cone)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0042802"(identical protein binding)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043113"(receptor clustering)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0050770"(regulation of axonogenesis)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033138"(positive regulation of peptidyl-serine phosphorylation)|go:"GO:0033148"(positive regulation of intracellular estrogen receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042060"(wound healing)|go:"GO:1900271"(regulation of long-term synaptic potentiation)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033923|interpro:IPR036936|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-399954|reactome:R-MMU-445144|reactome:R-MMU-445355|reactome:R-MMU-5218920|reactome:R-MMU-5621575|reactome:R-MMU-5627123|reactome:R-MMU-5687128|reactome:R-MMU-8964616|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013406|reactome:R-MMU-9013407|reactome:R-MMU-9013420|reactome:R-MMU-9013423|reactome:R-MMU-9013424|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0060244"(negative regulation of cell proliferation involved in contact inhibition)|go:"GO:0060996"(dendritic spine development)|go:"GO:0061052"(negative regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0061534"(gamma-aminobutyric acid secretion, neurotransmission)|go:"GO:0061535"(glutamate secretion, neurotransmission)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0090063"(positive regulation of microtubule nucleation)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0098597"(observational learning)|go:"GO:0098793"(presynapse)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099553"(trans-synaptic signaling by endocannabinoid, modulating synaptic transmission)|dip:DIP-32847N|mint:O88643	afcs:16524(primary-reference)|afcs:16524(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bTUdW3fkPL/cBbA+jzd78iNMw4c10090	rogid:96Cg20ZJuaGLWTlK9dOIdVHQLGQ10090	intact-crc:C074ECB12E8713E3|rigid:5RspEAhUspF5NnivBuxVTb4otQE	false	sufficient binding region:166-440	sufficient binding region:150-401	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ERU9	uniprotkb:P63141	intact:EBI-643756|uniprotkb:E9QM01|uniprotkb:Q61992|uniprotkb:Q8C9K9|ensembl:ENSMUSP00000003310	intact:EBI-644033|uniprotkb:P15386|uniprotkb:Q02010|uniprotkb:Q8C8W4|uniprotkb:B2RS05|ensembl:ENSMUSP00000041702|ensembl:ENSMUSP00000142873|ensembl:ENSMUSP00000143798	psi-mi:rbp2_mouse(display_long)|uniprotkb:Ran-binding protein 2(gene name synonym)|uniprotkb:Ranbp2(gene name)|psi-mi:Ranbp2(display_short)	psi-mi:kcna2_mouse(display_long)|uniprotkb:Voltage-gated potassium channel subunit Kv1.2(gene name synonym)|uniprotkb:Kcna2(gene name)|psi-mi:Kcna2(display_short)|uniprotkb:MK2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651684	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035370.2|reactome:R-MMU-191859|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3232142|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-4615885|reactome:R-MMU-5578749|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-9648025|ensembl:ENSMUSG00000003226(gene)|ensembl:ENSMUST00000003310(transcript)|go:"GO:0001975"(response to amphetamine)|go:"GO:0003723"(RNA binding)|go:"GO:0003755"(peptidyl-prolyl cis-trans isomerase activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005642"(annulate lamellae)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006111"(regulation of gluconeogenesis)|go:"GO:0006457"(protein folding)|go:"GO:0006607"(NLS-bearing protein import into nucleus)|go:"GO:0016925"(protein sumoylation)|go:"GO:0019789"(SUMO transferase activity)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031965"(nuclear membrane)|go:"GO:0033133"(positive regulation of glucokinase activity)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0044614"(nuclear pore cytoplasmic filaments)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0051028"(mRNA transport)|go:"GO:0051642"(centrosome localization)|go:"GO:0061665"(SUMO ligase activity)|go:"GO:1990723"(cytoplasmic periphery of the nuclear pore complex)|interpro:IPR000156(Ran Binding Protein 1)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR002130(Peptidyl-prolyl cis-trans isomerase, cyclophilin-type)|interpro:IPR011990(Tetratricopeptide-like helical)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019734|interpro:IPR020892|interpro:IPR022011|interpro:IPR029000|interpro:IPR036443|mint:Q9ERU9|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-170822	refseq:NP_032443.3|ensembl:ENSMUSG00000040724(gene)|ensembl:ENSMUST00000038695(transcript)|ensembl:ENSMUST00000196403(transcript)|ensembl:ENSMUST00000197470(transcript)|go:"GO:0005249"(voltage-gated potassium channel activity)|go:"GO:0005251"(delayed rectifier potassium channel activity)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0014059"(regulation of dopamine secretion)|go:"GO:0015271"(outward rectifier potassium channel activity)|go:"GO:0016021"(integral component of membrane)|go:"GO:0019228"(neuronal action potential)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019894"(kinesin binding)|go:"GO:0021633"(optic nerve structural organization)|go:"GO:0030027"(lamellipodium)|go:"GO:0030424"(axon)|go:"GO:0030425"(dendrite)|go:"GO:0031258"(lamellipodium membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0033010"(paranodal junction)|go:"GO:0034705"(potassium channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0043204"(perikaryon)|go:"GO:0043679"(axon terminus)|go:"GO:0044224"(juxtaparanode region of axon)|go:"GO:0044305"(calyx of Held)|go:"GO:0045188"(regulation of circadian sleep/wake cycle, non-REM sleep)|go:"GO:0051260"(protein homooligomerization)|go:"GO:0071805"(potassium ion transmembrane transport)|go:"GO:0097623"(potassium ion export across plasma membrane)|go:"GO:0099056"(integral component of presynaptic membrane)|interpro:IPR000210(BTB/POZ-like)|interpro:IPR003131(Potassium channel, voltage dependent, Kv,  tetramerisation)|interpro:IPR003968(Potassium channel, voltage dependent, Kv)|interpro:IPR003972(Potassium channel, voltage dependent, Kv1)|interpro:IPR004049(Potassium channel, voltage dependent, Kv1.2)|interpro:IPR005821(Ion transport)|interpro:IPR011333(BTB/POZ fold)|interpro:IPR027359|interpro:IPR028325|rcsb pdb:5WIE|reactome:R-MMU-1296072|refseq:XP_006501113.1|refseq:XP_006501114.1|refseq:XP_006501111.1|refseq:XP_006501112.1|refseq:XP_006501115.1|refseq:XP_006501116.1|refseq:XP_006501117.1|refseq:XP_006501118.1|dip:DIP-32239N	afcs:14666(primary-reference)|afcs:35179(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:cjIAIF0uuxSMRXErJiJc+OBJpAw10090	rogid:AimFojHr+yjzzdtmfxUCRBTvJyc10090	intact-crc:43D29D5EE341FA1C|rigid:z9vwmYxhl7F435OQlpqangPNsLI	false	sufficient binding region:1571-1896	sufficient binding region:1-160	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CR09	uniprotkb:Q8CFN5-4	intact:EBI-309143|ensembl:ENSMUSP00000078914|ensembl:ENSMUSP00000106933	intact:EBI-643822|ensembl:ENSMUSP00000143742	psi-mi:ufc1_mouse(display_long)|uniprotkb:Ufc1(gene name)|psi-mi:Ufc1(display_short)	psi-mi:q8cfn5-4(display_long)|uniprotkb:Myocyte enhancer factor 2C(gene name synonym)|uniprotkb:Mef2c(gene name)|psi-mi:Mef2c(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651726	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079664.1|ensembl:ENSMUSG00000062963(gene)|ensembl:ENSMUST00000080001(transcript)|ensembl:ENSMUST00000111302(transcript)|go:"GO:0007420"(brain development)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0061657"(UFM1 conjugating enzyme activity)|go:"GO:0061709"(reticulophagy)|go:"GO:0071568"(UFM1 transferase activity)|go:"GO:0071569"(protein ufmylation)|go:"GO:1990592"(protein K69-linked ufmylation)|interpro:IPR014806(Protein of unknown function DUF1782)|interpro:IPR016135(Ubiquitin-conjugating enzyme/RWD-like)|mint:Q9CR09	intact:EBI-643797(mef2c_mouse)|ensembl:ENSMUSG00000005583(gene)|ensembl:ENSMUST00000198199(transcript)	afcs:7289(primary-reference)|afcs:30074(secondary-ac)	-	isoform-comment:Contains a phosphothreonine at position 108.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sYaZHkqlJvk/lKhf8AVLGvFDBkg10090	rogid:1ZAceE7Fb8MF58fpsYpHgRfA+pM10090	intact-crc:3266CC1BCC280098|rigid:8lDl7XPnHmhSn6mUwnZbh+d/NXw	false	sufficient binding region:18-167	sufficient binding region:250-432	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8VH51	uniprotkb:P63001	intact:EBI-644098|uniprotkb:Q5RJI0|uniprotkb:Q99KV0|ensembl:ENSMUSP00000105216	intact:EBI-413646|ensembl:ENSMUSP00000079380|uniprotkb:O95501|uniprotkb:P15154|uniprotkb:Q9BTB4	psi-mi:rbm39_mouse(display_long)|uniprotkb:RNA-binding motif protein 39(gene name synonym)|uniprotkb:RNA-binding region-containing protein 2(gene name synonym)|uniprotkb:Coactivator of activating protein 1 and estrogen receptors(gene name synonym)|uniprotkb:Rbm39(gene name)|psi-mi:Rbm39(display_short)|uniprotkb:Caper(gene name synonym)|uniprotkb:Rnpc2(gene name synonym)	psi-mi:rac1_mouse(display_long)|uniprotkb:Rac1(gene name)|psi-mi:Rac1(display_short)|uniprotkb:p21-Rac1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651748	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_573505.2|ensembl:ENSMUSG00000027620(gene)|ensembl:ENSMUST00000109587(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0008380"(RNA splicing)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0016607"(nuclear speck)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050733"(RS domain binding)|interpro:IPR000504(RNA recognition motif, RNP-1)|interpro:IPR003954(RNA recognition, region 1)|interpro:IPR006509(Splicing factor, CC1-like)|interpro:IPR012677(Nucleotide-binding, alpha-beta plait)|interpro:IPR029123|interpro:IPR035979|mint:Q8VH51|rcsb pdb:2LQ5|rcsb pdb:3S6E|rcsb pdb:4J5O|rcsb pdb:4RU2|rcsb pdb:5CXT|refseq:XP_011237629.1|refseq:NP_001278043.1|refseq:NP_001278044.1|refseq:XP_017171483.1|refseq:XP_017171494.1|refseq:XP_017171497.1|refseq:XP_011237628.1|refseq:XP_017171487.1	go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002093"(auditory receptor cell morphogenesis)|go:"GO:0002551"(mast cell chemotaxis)|go:"GO:0003376"(sphingosine-1-phosphate receptor signaling pathway)|go:"GO:0003382"(epithelial cell morphogenesis)|ensembl:ENSMUSG00000001847(gene)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|ensembl:ENSMUST00000080537(transcript)|go:"GO:0005938"(cell cortex)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000242"(pericentriolar material)|go:"GO:0001764"(neuron migration)|go:"GO:0006897"(endocytosis)|go:"GO:0006911"(phagocytosis, engulfment)|go:"GO:0006935"(chemotaxis)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007010"(cytoskeleton organization)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0001891"(phagocytic cup)|go:"GO:0008045"(motor neuron axon guidance)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008361"(regulation of cell size)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0010592"(positive regulation of lamellipodium assembly)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0010764"(negative regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016020"(membrane)|go:"GO:0016358"(dendrite development)|go:"GO:0016477"(cell migration)|go:"GO:0007411"(axon guidance)|go:"GO:0016601"(Rac protein signal transduction)|go:"GO:0019897"(extrinsic component of plasma membrane)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021799"(cerebral cortex radially oriented cell migration)|go:"GO:0021831"(embryonic olfactory bulb interneuron precursor migration)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0030900"(forebrain development)|go:"GO:0031116"(positive regulation of microtubule polymerization)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031529"(ruffle organization)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032707"(negative regulation of interleukin-23 production)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|go:"GO:0035567"(non-canonical Wnt signaling pathway)|go:"GO:0035774"(positive regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0036464"(cytoplasmic ribonucleoprotein granule)|go:"GO:0042470"(melanosome)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042995"(cell projection)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0043652"(engulfment of apoptotic cell)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045216"(cell-cell junction organization)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045453"(bone resorption)|go:"GO:0045740"(positive regulation of DNA replication)|go:"GO:0046425"(regulation of receptor signaling pathway via JAK-STAT)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0048168"(regulation of neuronal synaptic plasticity)|go:"GO:0048532"(anatomical structure arrangement)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0048870"(cell motility)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0051022"(Rho GDP-dissociation inhibitor binding)|go:"GO:0051117"(ATPase binding)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051496"(positive regulation of stress fiber assembly)|go:"GO:0051668"(localization within membrane)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0060071"(Wnt signaling pathway, planar cell polarity pathway)|go:"GO:0060091"(kinocilium)|go:"GO:0060263"(regulation of respiratory burst)|go:"GO:0060999"(positive regulation of dendritic spine development)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:0071542"(dopaminergic neuron differentiation)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0090023"(positive regulation of neutrophil chemotaxis)|go:"GO:0090103"(cochlea morphogenesis)|go:"GO:0097178"(ruffle assembly)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|go:"GO:1902622"(regulation of neutrophil migration)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:2000386"(positive regulation of ovarian follicle development)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|go:"GO:0061344"(regulation of cell adhesion involved in heart morphogenesis)|interpro:IPR027417|mint:P63001|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-1433557|interpro:IPR005225(Small GTP-binding protein)|reactome:R-MMU-193648|reactome:R-MMU-2029482|reactome:R-MMU-2424491|reactome:R-MMU-2871796|reactome:R-MMU-376172|reactome:R-MMU-389359|reactome:R-MMU-3928662|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-4086400|reactome:R-MMU-416550|reactome:R-MMU-5663213|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663220|reactome:R-MMU-5668599|reactome:R-MMU-5687128|reactome:R-MMU-6798695|reactome:R-MMU-445144|reactome:R-MMU-6811558|reactome:R-MMU-8849471|reactome:R-MMU-8875555|reactome:R-MMU-9013149|reactome:R-MMU-9032759|reactome:R-MMU-983231|reactome:R-MMU-5218920|reactome:R-MMU-5625740|reactome:R-MMU-5625900|reactome:R-MMU-5625970|reactome:R-MMU-5626467|reactome:R-MMU-5627123|refseq:NP_033033.1|dip:DIP-31545N	afcs:23265(primary-reference)|afcs:33886(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:dW5PuXllczFeyQ6ask6CFrukMKk10090	rogid:8rkYyZSFL5tIfbRNKZgP/UDxD+A10090	intact-crc:5AD86438FBF44CA2|rigid:oDsEd+sPaqEcMtJxVclMq4GQMZU	false	sufficient binding region:241-391	sufficient binding region:50-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648421	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:7166DC56768772EC|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:101-365	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648431	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:C238EBF760B405F0|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:130-443	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648451	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:8DBF67C9D17FFB47|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:227-369	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648471	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:FF89A50BC6F61341|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:235-443	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PT1	uniprotkb:P60764	intact:EBI-494354|uniprotkb:Q5M9P6|uniprotkb:Q8BPI0|uniprotkb:Q99KC4|ensembl:ENSMUSP00000063714|ensembl:ENSMUSP00000101803	intact:EBI-644949|uniprotkb:O14658|ensembl:ENSMUSP00000018156	psi-mi:gdir1_mouse(display_long)|uniprotkb:Rho-GDI alpha(gene name synonym)|uniprotkb:GDI-1(gene name synonym)|uniprotkb:Arhgdia(gene name)|psi-mi:Arhgdia(display_short)|uniprotkb:C87222(gene name synonym)|uniprotkb:Gdi1(gene name synonym)	psi-mi:rac3_mouse(display_long)|uniprotkb:p21-Rac3(gene name synonym)|uniprotkb:Rac3(gene name)|psi-mi:Rac3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653336	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006532612.1|refseq:NP_598557.3|ensembl:ENSMUST00000067936(transcript)|ensembl:ENSMUST00000106197(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071461"(cellular response to redox state)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024792|mint:Q99PT1|rcsb pdb:4F38|reactome:R-MMU-193634|reactome:R-MMU-209563|reactome:R-MMU-8980692|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013407|reactome:R-MMU-9013408|go:"GO:0071260"(cellular response to mechanical stimulus)|ensembl:ENSMUSG00000025132(gene)	refseq:NP_573486.1|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|ensembl:ENSMUSG00000018012(gene)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|ensembl:ENSMUST00000018156(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0071944"(cell periphery)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P60764|reactome:R-MMU-4086400|reactome:R-MMU-9013423	afcs:35065(primary-reference)|afcs:34645(secondary-ac)	-	-	caution:The prey construct contains 13 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T543bldr5c9EXiP1DXLnG6GuTsc10090	rogid:YWu9Tmqxzxu49RSwmyfhawoOUis10090	intact-crc:D169C31A3589A471|rigid:JOXHixVvamjKd96lLtIGyqGtLFE	false	sufficient binding region:1-168	sufficient binding region:1-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PT1	uniprotkb:P60764	intact:EBI-494354|uniprotkb:Q5M9P6|uniprotkb:Q8BPI0|uniprotkb:Q99KC4|ensembl:ENSMUSP00000063714|ensembl:ENSMUSP00000101803	intact:EBI-644949|uniprotkb:O14658|ensembl:ENSMUSP00000018156	psi-mi:gdir1_mouse(display_long)|uniprotkb:Rho-GDI alpha(gene name synonym)|uniprotkb:GDI-1(gene name synonym)|uniprotkb:Arhgdia(gene name)|psi-mi:Arhgdia(display_short)|uniprotkb:C87222(gene name synonym)|uniprotkb:Gdi1(gene name synonym)	psi-mi:rac3_mouse(display_long)|uniprotkb:p21-Rac3(gene name synonym)|uniprotkb:Rac3(gene name)|psi-mi:Rac3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653357	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:XP_006532612.1|refseq:NP_598557.3|ensembl:ENSMUST00000067936(transcript)|ensembl:ENSMUST00000106197(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0016020"(membrane)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0045202"(synapse)|go:"GO:0051879"(Hsp90 protein binding)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0071461"(cellular response to redox state)|go:"GO:0071526"(semaphorin-plexin signaling pathway)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024792|mint:Q99PT1|rcsb pdb:4F38|reactome:R-MMU-193634|reactome:R-MMU-209563|reactome:R-MMU-8980692|reactome:R-MMU-9013106|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013407|reactome:R-MMU-9013408|go:"GO:0071260"(cellular response to mechanical stimulus)|ensembl:ENSMUSG00000025132(gene)	refseq:NP_573486.1|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|ensembl:ENSMUSG00000018012(gene)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|ensembl:ENSMUST00000018156(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0071944"(cell periphery)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P60764|reactome:R-MMU-4086400|reactome:R-MMU-9013423	afcs:35065(primary-reference)|afcs:34645(secondary-ac)	-	-	caution:The prey construct contains 13 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:T543bldr5c9EXiP1DXLnG6GuTsc10090	rogid:YWu9Tmqxzxu49RSwmyfhawoOUis10090	intact-crc:0B2B13A32F44CD4A|rigid:JOXHixVvamjKd96lLtIGyqGtLFE	false	sufficient binding region:1-204	sufficient binding region:1-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61599	uniprotkb:P60764	intact:EBI-644961|uniprotkb:Q3TEB3|ensembl:ENSMUSP00000032344|ensembl:ENSMUSP00000107522|ensembl:ENSMUSP00000107523	intact:EBI-644949|uniprotkb:O14658|ensembl:ENSMUSP00000018156	psi-mi:gdir2_mouse(display_long)|uniprotkb:Rho-GDI beta(gene name synonym)|uniprotkb:D4(gene name synonym)|uniprotkb:Arhgdib(gene name)|psi-mi:Arhgdib(display_short)|uniprotkb:Gdid4(gene name synonym)	psi-mi:rac3_mouse(display_long)|uniprotkb:p21-Rac3(gene name synonym)|uniprotkb:Rac3(gene name)|psi-mi:Rac3(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653376	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_031512.1|refseq:NP_001288230.1|refseq:NP_001288232.1|refseq:NP_001288234.1|refseq:NP_001288237.1|refseq:NP_001288238.1|refseq:XP_006505467.1|ensembl:ENSMUSG00000030220(gene)|ensembl:ENSMUST00000032344(transcript)|ensembl:ENSMUST00000111891(transcript)|ensembl:ENSMUST00000111892(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0005094"(Rho GDP-dissociation inhibitor activity)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0007266"(Rho protein signal transduction)|go:"GO:0016020"(membrane)|go:"GO:0031267"(small GTPase binding)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0071461"(cellular response to redox state)|go:"GO:1901164"(negative regulation of trophoblast cell migration)|go:"GO:2000249"(regulation of actin cytoskeleton reorganization)|interpro:IPR000406(RHO protein GDP dissociation inhibitor)|interpro:IPR014756(Immunoglobulin E-set)|interpro:IPR024792|mint:Q61599|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149|reactome:R-MMU-9013407|reactome:R-MMU-9013408|reactome:R-MMU-9013423	refseq:NP_573486.1|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0007264"(small GTPase mediated signal transduction)|ensembl:ENSMUSG00000018012(gene)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0012505"(endomembrane system)|go:"GO:0014041"(regulation of neuron maturation)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0021894"(cerebral cortex GABAergic interneuron development)|go:"GO:0022604"(regulation of cell morphogenesis)|go:"GO:0030027"(lamellipodium)|go:"GO:0030031"(cell projection assembly)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030426"(growth cone)|go:"GO:0030865"(cortical cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|ensembl:ENSMUST00000018156(transcript)|go:"GO:0003924"(GTPase activity)|go:"GO:0003925"(G protein activity)|go:"GO:0005525"(GTP binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0007015"(actin filament organization)|go:"GO:0031941"(filamentous actin)|go:"GO:0032956"(regulation of actin cytoskeleton organization)|go:"GO:0033630"(positive regulation of cell adhesion mediated by integrin)|go:"GO:0042995"(cell projection)|go:"GO:0043005"(neuron projection)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045202"(synapse)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050885"(neuromuscular process controlling balance)|go:"GO:0050905"(neuromuscular process)|go:"GO:0051932"(synaptic transmission, GABAergic)|go:"GO:0071944"(cell periphery)|go:"GO:1900026"(positive regulation of substrate adhesion-dependent cell spreading)|interpro:IPR001806(Ras GTPase)|interpro:IPR003578(Ras small GTPase, Rho type)|interpro:IPR005225(Small GTP-binding protein)|interpro:IPR027417|mint:P60764|reactome:R-MMU-4086400|reactome:R-MMU-9013423	afcs:35065(primary-reference)|afcs:35521(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:q4GoTuJcORyPFUiFyFJNmGFkMog10090	rogid:YWu9Tmqxzxu49RSwmyfhawoOUis10090	intact-crc:BE3B5EA7545963C4|rigid:NWkH0zeCHKDJzlWAGP1EsHqnqi4	false	sufficient binding region:10-174	sufficient binding region:1-192	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51807	uniprotkb:P39688	intact:EBI-642797|uniprotkb:Q5M8S6|ensembl:ENSMUSP00000137171|ensembl:ENSMUSP00000135978|ensembl:ENSMUSP00000090644|ensembl:ENSMUSP00000127990	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:dylt1_mouse(display_long)|uniprotkb:T-complex testis-specific protein 1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym)|uniprotkb:Tctex1(gene name synonym)|uniprotkb:Tctex-1(gene name synonym)|uniprotkb:Dynlt1(gene name)|psi-mi:Dynlt1(display_short)|uniprotkb:Activator of G-protein signaling 2(gene name synonym)|uniprotkb:Tctel1(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653425	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001160099.1|refseq:NP_001160101.1|refseq:NP_001160102.1|refseq:NP_033368.1|ensembl:ENSMUST00000092966(transcript)|ensembl:ENSMUST00000169415(transcript)|ensembl:ENSMUST00000179554(transcript)|ensembl:ENSMUST00000179569(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0099503"(secretory vesicle)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|mint:P51807|rcsb pdb:5WI4|reactome:R-MMU-6798695|go:"GO:0030742"(GTP-dependent protein binding)|ensembl:ENSMUSG00000000579(gene)|ensembl:ENSMUSG00000092074(gene)|ensembl:ENSMUSG00000095677(gene)|ensembl:ENSMUSG00000096255(gene)|refseq:XP_017172676.1	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:9401(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fn6QN4J3aA++93iJwG3rFDjPBvM10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:4D44D3596F899B06|rigid:jhHT445UrXIn2xRjN6t7m27AtE0	false	sufficient binding region:1-113	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P34152	uniprotkb:P39688	intact:EBI-77070|uniprotkb:Q5DTH7|uniprotkb:Q8C513|uniprotkb:Q8CFH7|uniprotkb:Q8CHM2|uniprotkb:Q8K2S0|uniprotkb:Q9DAW3|intact:EBI-644981|uniprotkb:O08578|ensembl:ENSMUSP00000105663	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:fak1_mouse(display_long)|uniprotkb:Ptk2(gene name)|psi-mi:Ptk2(display_short)|uniprotkb:Fadk(gene name synonym)|uniprotkb:Fak(gene name synonym)|uniprotkb:Fak1(gene name synonym)|uniprotkb:Kiaa4203(gene name synonym)|uniprotkb:pp125FAK(gene name synonym)|uniprotkb:Protein-tyrosine kinase 2(gene name synonym)|uniprotkb:Focal adhesion kinase-related nonkinase(gene name synonym)|uniprotkb:p125FAK(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653453	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123881.1|refseq:NP_032008.2|refseq:XP_006520496.1|dip:DIP-31045N|ensembl:ENSMUSG00000022607(gene)|ensembl:ENSMUST00000110036(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000226"(microtubule cytoskeleton organization)|go:"GO:0001525"(angiogenesis)|go:"GO:0001568"(blood vessel development)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001725"(stress fiber)|go:"GO:0001764"(neuron migration)|go:"GO:0001932"(regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003779"(actin binding)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007097"(nuclear migration)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007172"(signal complex assembly)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007254"(JNK cascade)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0008432"(JUN kinase binding)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010632"(regulation of epithelial cell migration)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014704"(intercalated disc)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0016477"(cell migration)|go:"GO:0016604"(nuclear body)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021955"(central nervous system neuron axonogenesis)|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030027"(lamellipodium)|go:"GO:0030154"(cell differentiation)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030198"(extracellular matrix organization)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030644"(cellular chloride ion homeostasis)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0036064"(ciliary basal body)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042311"(vasodilation)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043542"(endothelial cell migration)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045785"(positive regulation of cell adhesion)|go:"GO:0045860"(positive regulation of protein kinase activity)|go:"GO:0046621"(negative regulation of organ growth)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050766"(positive regulation of phagocytosis)|go:"GO:0050771"(negative regulation of axonogenesis)|go:"GO:0050806"(positive regulation of synaptic transmission)|go:"GO:0051893"(regulation of focal adhesion assembly)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051964"(negative regulation of synapse assembly)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0098794"(postsynapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1900024"(regulation of substrate adhesion-dependent cell spreading)|go:"GO:2000060"(positive regulation of ubiquitin-dependent protein catabolic process)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR005189(Focal adhesion targeting region)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR014352(FERM/acyl-CoA-binding protein, 3-helical bundle)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR019748|interpro:IPR019749|interpro:IPR020635|interpro:IPR029071|interpro:IPR035963|interpro:IPR036137|interpro:IPR041390|interpro:IPR041784|mint:P34152|rcsb pdb:1K40|rcsb pdb:1KKY|rcsb pdb:1KL0|rcsb pdb:5F28|rcsb pdb:6BZ3|reactome:R-MMU-111465|reactome:R-MMU-2029482|reactome:R-MMU-354192|reactome:R-MMU-354194|reactome:R-MMU-372708|reactome:R-MMU-375165|reactome:R-MMU-3928662|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-5673001|reactome:R-MMU-8874081|reactome:R-MMU-9009391	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:55280(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2019/02/20	rogid:ZO/rmkDeJv5vec4ug3C3YrIwSIM10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:2ED83A4E01BB8BEC|rigid:CvbptCRCp7ChGJ06V7SiZNEOBuU	false	sufficient binding region:338-688	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99PM9	uniprotkb:P39688	intact:EBI-644712|ensembl:ENSMUSP00000060202	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:uck2_mouse(display_long)|uniprotkb:Uridine monophosphokinase 2(gene name synonym)|uniprotkb:Cytidine monophosphokinase 2(gene name synonym)|uniprotkb:Uck2(gene name)|psi-mi:Uck2(display_short)|uniprotkb:Umpk(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653483	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_109649.1|ensembl:ENSMUSG00000026558(gene)|ensembl:ENSMUST00000053686(transcript)|go:"GO:0004849"(uridine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044206"(UMP salvage)|go:"GO:0044211"(CTP salvage)|interpro:IPR000764(Uridine kinase)|interpro:IPR027417|interpro:IPR029925|reactome:R-MMU-73614|interpro:IPR006083(Phosphoribulokinase/uridine kinase)	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:33845(secondary-ac)	-	-	caution:The prey construct contains 56 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:E+lz+mNwgjWmI4Lgx8J9eEuoxRY10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:817BC93A1B433458|rigid:UWtDOWW3D8fUlrdsFxZyLSboyvM	false	sufficient binding region:1-261	sufficient binding region:2-261	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6F5E0	uniprotkb:P09055	intact:EBI-645317	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:tm158_mouse(display_long)|uniprotkb:Ras-induced senescence protein 1(gene name synonym)|uniprotkb:40 kDa BINP-binding protein(gene name synonym)|uniprotkb:Tmem158(gene name)|psi-mi:Tmem158(display_short)|uniprotkb:Mbbp(gene name synonym)|uniprotkb:Ris1(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654210	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR038962|go:"GO:0016021"(integral component of membrane)|go:"GO:0042277"(peptide binding)	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:18892(primary-reference)|afcs:18892(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JGR2NiDmjrv92CXOqmsbpneuYmw10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:CC05577202D7E087|rigid:0SQf8C86XsS9ZXQeQXphd89tFOM	false	sufficient binding region:173-286	sufficient binding region:350-602	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6F5E0	uniprotkb:P09055	intact:EBI-645317	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:tm158_mouse(display_long)|uniprotkb:Ras-induced senescence protein 1(gene name synonym)|uniprotkb:40 kDa BINP-binding protein(gene name synonym)|uniprotkb:Tmem158(gene name)|psi-mi:Tmem158(display_short)|uniprotkb:Mbbp(gene name synonym)|uniprotkb:Ris1(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654230	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR038962|go:"GO:0016021"(integral component of membrane)|go:"GO:0042277"(peptide binding)	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:18892(primary-reference)|afcs:18892(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JGR2NiDmjrv92CXOqmsbpneuYmw10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:A08B51E5A8253EAA|rigid:0SQf8C86XsS9ZXQeQXphd89tFOM	false	sufficient binding region:239-286	sufficient binding region:350-602	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q924X9	uniprotkb:P12367	intact:EBI-685481	intact:EBI-645747	psi-mi:q924x9_mouse(display_long)|uniprotkb:Akap13(gene name)|psi-mi:Akap13(display_short)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688190	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR028852|go:"GO:0004691"(cAMP-dependent protein kinase activity)|go:"GO:0035023"(regulation of Rho protein signal transduction)	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	afcs:19329(primary-reference)|afcs:53754(primary-reference)|afcs:53754(secondary-ac)	caution:"Protein [uniprotkb:Q924X9] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"|comment:"A kinase (PRKA) anchor protein 13; type II cAMP-dependent protein kinase anchoring protein Ht31; BRX; LBC; AKAP-Lbc; PROTO-LB; PROTO-LBC"|comment:AfCS Y2H protein. Translated from nucleotide sequence.|caution:"The sequence differs in amino-terminus to AfCS ID: A000240 and is truncated at the C-terminus."|comment:"similar to a mouse AKAP13 fragment (99%)."	-	caution:"Protein [uniprotkb:Q924X9] has undergone a significant sequence change since this entry was originally annotated which may effect the results shown. For further information, please access the IntAct curation manual and for details of the sequence change go to [unisave]"|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:iGu7PI8I+0GMvjAKc8o5okpPcUg10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	intact-crc:0A7C64D574DC6F70|rigid:joqswUaaxQ31A6hvgwCMTBteAkE	false	sufficient binding region:?-?	sufficient binding region:2-126	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-688037	uniprotkb:P12367	-	intact:EBI-645747	psi-mi:akap150_mouse_protei(display_short)|psi-mi:EBI-688037(display_long)	psi-mi:kap2_mouse(display_long)|uniprotkb:Prkar2a(gene name)|psi-mi:Prkar2a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688214	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	afcs:53763(primary-reference)	rcsb pdb:3J4Q|rcsb pdb:3J4R|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR018490|interpro:IPR018488|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR014710(RmlC-like jelly roll fold)|rcsb pdb:1KMU|rcsb pdb:1KMW|rcsb pdb:1L6E|rcsb pdb:1R2A|rcsb pdb:2IZY|rcsb pdb:2QVS|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030315"(T-tubule)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031698"(beta-2 adrenergic receptor binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0036094"(small molecule binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-5610787|reactome:R-MMU-983231|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720	afcs:19329(primary-reference)|afcs:53763(primary-reference)|afcs:53763(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:"AfCS Y2H protein 53763. Sequence retrieved from cross-reference : Protein GI: 20909862."|comment:"Similar to rat A-kinase anchoring protein AKAP150 (70%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:HGxHCsdYpmSTll1mCVpRztwq4Dw10090	rogid:/SHXBtLe0gVa9Rf+boM1hNLRAms10090	intact-crc:C9CA14C99141D5BD|rigid:PNsYMRgthTuGCYH362G5ewA4+C4	false	sufficient binding region:378-688	sufficient binding region:2-126	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61084	uniprotkb:Q9WVS7	intact:EBI-446250|ensembl:ENSMUSP00000002044	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:m3k3_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase 3(gene name synonym)|uniprotkb:Map3k3(gene name)|psi-mi:Map3k3(display_short)|uniprotkb:Mekk3(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648577	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036077.1|ensembl:ENSMUSG00000020700(gene)|ensembl:ENSMUST00000002044(transcript)|go:"GO:0001568"(blood vessel development)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004709"(MAP kinase kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0071864"(positive regulation of cell proliferation in bone marrow)|go:"GO:0090050"(positive regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900745"(positive regulation of p38MAPK cascade)|go:"GO:2000773"(negative regulation of cellular senescence)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR034879|mint:Q61084|reactome:R-MMU-9020702	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:9754(secondary-ac)	-	-	caution:The prey construct contains 4 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:U+hPCo3Bms3bXgD1kDtEFTKcnqo10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:BB6EA22E67808729|rigid:uYB3dqnetF16Y1kgYlUbxJ/mg6Y	false	sufficient binding region:1-207	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WVS7	uniprotkb:Q02248	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	intact:EBI-397872|ensembl:ENSMUSP00000007130|ensembl:ENSMUSP00000136294|uniprotkb:Q922W1|uniprotkb:Q9D335	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:ctnb1_mouse(display_long)|uniprotkb:Beta-catenin(gene name synonym)|uniprotkb:Ctnnb1(gene name)|psi-mi:Ctnnb1(display_short)|uniprotkb:Catnb(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653494	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	go:"GO:0045667"(regulation of osteoblast differentiation)|go:"GO:0045603"(positive regulation of endothelial cell differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045670"(regulation of osteoclast differentiation)|go:"GO:0045671"(negative regulation of osteoclast differentiation)|go:"GO:0045743"(positive regulation of fibroblast growth factor receptor signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045976"(negative regulation of mitotic cell cycle, embryonic)|go:"GO:0046332"(SMAD binding)|go:"GO:0048469"(cell maturation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048489"(synaptic vesicle transport)|go:"GO:0048513"(animal organ development)|go:"GO:0048538"(thymus development)|go:"GO:0048568"(embryonic organ development)|go:"GO:0048599"(oocyte development)|go:"GO:0048617"(embryonic foregut morphogenesis)|go:"GO:0048643"(positive regulation of skeletal muscle tissue development)|go:"GO:0048660"(regulation of smooth muscle cell proliferation)|go:"GO:0048715"(negative regulation of oligodendrocyte differentiation)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0050808"(synapse organization)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051145"(smooth muscle cell differentiation)|go:"GO:0051571"(positive regulation of histone H3-K4 methylation)|go:"GO:0051884"(regulation of timing of anagen)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0060066"(oviduct development)|go:"GO:0060070"(canonical Wnt signaling pathway)|go:"GO:0060173"(limb development)|go:"GO:0060439"(trachea morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060441"(epithelial tube branching involved in lung morphogenesis)|refseq:NP_001159374.1|refseq:NP_031640.1|ensembl:ENSMUSG00000006932(gene)|ensembl:ENSMUST00000007130(transcript)|ensembl:ENSMUST00000178812(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0000578"(embryonic axis specification)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000791"(euchromatin)|go:"GO:0000904"(cell morphogenesis involved in differentiation)|go:"GO:0000922"(spindle pole)|go:"GO:0001221"(transcription coregulator binding)|go:"GO:0001501"(skeletal system development)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001570"(vasculogenesis)|go:"GO:0001658"(branching involved in ureteric bud morphogenesis)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001702"(gastrulation with mouth forming second)|go:"GO:0001706"(endoderm formation)|go:"GO:0001708"(cell fate specification)|go:"GO:0001709"(cell fate determination)|go:"GO:0001711"(endodermal cell fate commitment)|go:"GO:0001764"(neuron migration)|go:"GO:0001822"(kidney development)|go:"GO:0001840"(neural plate development)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001944"(vasculature development)|go:"GO:0002052"(positive regulation of neuroblast proliferation)|go:"GO:0002053"(positive regulation of mesenchymal cell proliferation)|go:"GO:0002089"(lens morphogenesis in camera-type eye)|go:"GO:0003223"(ventricular compact myocardium morphogenesis)|go:"GO:0003266"(regulation of secondary heart field cardioblast proliferation)|go:"GO:0003338"(metanephros morphogenesis)|go:"GO:0003340"(negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)|go:"GO:0003682"(chromatin binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005916"(fascia adherens)|go:"GO:0007155"(cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007268"(chemical synaptic transmission)|go:"GO:0007398"(ectoderm development)|go:"GO:0007403"(glial cell fate determination)|go:"GO:0005923"(bicellular tight junction)|go:"GO:0007507"(heart development)|go:"GO:0005938"(cell cortex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008013"(beta-catenin binding)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009948"(anterior/posterior axis specification)|go:"GO:0009950"(dorsal/ventral axis specification)|go:"GO:0009953"(dorsal/ventral pattern formation)|go:"GO:0009954"(proximal/distal pattern formation)|go:"GO:0009987"(cellular process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010718"(positive regulation of epithelial to mesenchymal transition)|go:"GO:0010909"(positive regulation of heparan sulfate proteoglycan biosynthetic process)|go:"GO:0014010"(Schwann cell proliferation)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016327"(apicolateral plasma membrane)|go:"GO:0016328"(lateral plasma membrane)|go:"GO:0016331"(morphogenesis of embryonic epithelium)|go:"GO:0016342"(catenin complex)|go:"GO:0016525"(negative regulation of angiogenesis)|go:"GO:0016600"(flotillin complex)|go:"GO:0016922"(nuclear receptor binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0021819"(layer formation in cerebral cortex)|go:"GO:0022009"(central nervous system vasculogenesis)|go:"GO:0022405"(hair cycle process)|go:"GO:0030027"(lamellipodium)|go:"GO:0030054"(cell junction)|go:"GO:0030018"(Z disc)|go:"GO:0030154"(cell differentiation)|go:"GO:0030182"(neuron differentiation)|go:"GO:0030217"(T cell differentiation)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030331"(estrogen receptor binding)|go:"GO:0030539"(male genitalia development)|go:"GO:0030856"(regulation of epithelial cell differentiation)|go:"GO:0030858"(positive regulation of epithelial cell differentiation)|go:"GO:0030877"(beta-catenin destruction complex)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030900"(forebrain development)|go:"GO:0030901"(midbrain development)|go:"GO:0030902"(hindbrain development)|go:"GO:0030997"(regulation of centriole-centriole cohesion)|go:"GO:0031016"(pancreas development)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031253"(cell projection membrane)|go:"GO:0031528"(microvillus membrane)|go:"GO:0031641"(regulation of myelination)|go:"GO:0031965"(nuclear membrane)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032355"(response to estradiol)|go:"GO:0032968"(positive regulation of transcription elongation from RNA polymerase II promoter)|go:"GO:0032991"(protein-containing complex)|go:"GO:0032993"(protein-DNA complex)|go:"GO:0033077"(T cell differentiation in thymus)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0034097"(response to cytokine)|go:"GO:0034332"(adherens junction organization)|go:"GO:0034333"(adherens junction assembly)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0034613"(cellular protein localization)|go:"GO:0034750"(Scrib-APC-beta-catenin complex)|go:"GO:0035050"(embryonic heart tube development)|go:"GO:0035112"(genitalia morphogenesis)|go:"GO:0035115"(embryonic forelimb morphogenesis)|go:"GO:0035116"(embryonic hindlimb morphogenesis)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0036023"(embryonic skeletal limb joint morphogenesis)|go:"GO:0036520"(astrocyte-dopaminergic neuron signaling)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042129"(regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042493"|go:"GO:0042733"(embryonic digit morphogenesis)|go:"GO:0042734"(presynaptic membrane)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043198"(dendritic shaft)|go:"GO:0043296"(apical junction complex)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043525"(positive regulation of neuron apoptotic process)|go:"GO:0043588"(skin development)|go:"GO:0043627"(response to estrogen)|go:"GO:0044093"(positive regulation of molecular function)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044334"(canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)|go:"GO:0044338"(canonical Wnt signaling pathway involved in mesenchymal stem cell differentiation)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045294"(alpha-catenin binding)|go:"GO:0045296"(cadherin binding)|go:"GO:0045453"(bone resorption)|go:"GO:0045595"(regulation of cell differentiation)|go:"GO:0045596"(negative regulation of cell differentiation)|dip:DIP-31560N|go:"GO:0060479"(lung cell differentiation)|go:"GO:0060484"(lung-associated mesenchyme development)|go:"GO:0060485"(mesenchyme development)|go:"GO:0060492"(lung induction)|go:"GO:0060742"(epithelial cell differentiation involved in prostate gland development)|go:"GO:0060769"(positive regulation of epithelial cell proliferation involved in prostate gland development)|go:"GO:0060789"(hair follicle placode formation)|go:"GO:0060916"(mesenchymal cell proliferation involved in lung development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0060982"(coronary artery morphogenesis)|go:"GO:0060983"(epicardium-derived cardiac vascular smooth muscle cell differentiation)|go:"GO:0061047"(positive regulation of branching involved in lung morphogenesis)|go:"GO:0061154"(endothelial tube morphogenesis)|go:"GO:0061198"(fungiform papilla formation)|go:"GO:0061324"(canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)|go:"GO:0061549"(sympathetic ganglion development)|go:"GO:0061550"(cranial ganglion development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070369"(beta-catenin-TCF7L2 complex)|go:"GO:0070411"(I-SMAD binding)|go:"GO:0070602"(regulation of centromeric sister chromatid cohesion)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0071681"(cellular response to indole-3-methanol)|go:"GO:0071944"(cell periphery)|go:"GO:0072033"(renal vesicle formation)|go:"GO:0072053"(renal inner medulla development)|go:"GO:0072054"(renal outer medulla development)|go:"GO:0072079"(nephron tubule formation)|go:"GO:0072132"(mesenchyme morphogenesis)|go:"GO:0072182"(regulation of nephron tubule epithelial cell differentiation)|go:"GO:0090279"(regulation of calcium ion import)|go:"GO:0097091"(synaptic vesicle clustering)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098831"(presynaptic active zone cytoplasmic component)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1903204"(negative regulation of oxidative stress-induced neuron death)|go:"GO:1904796"(regulation of core promoter binding)|go:"GO:1904798"(positive regulation of core promoter binding)|go:"GO:1904888"(cranial skeletal system development)|go:"GO:1904948"(midbrain dopaminergic neuron differentiation)|go:"GO:1904954"(canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)|go:"GO:1990138"(neuron projection extension)|go:"GO:1990226"(histone methyltransferase binding)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|go:"GO:1990403"(embryonic brain development)|go:"GO:1990791"(dorsal root ganglion development)|go:"GO:1990907"(beta-catenin-TCF complex)|go:"GO:1990909"(Wnt signalosome)|go:"GO:2000008"(regulation of protein localization to cell surface)|go:"GO:2000017"(positive regulation of determination of dorsal identity)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|go:"GO:2001234"(negative regulation of apoptotic signaling pathway)|interpro:IPR000225(Armadillo)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013284(Beta-catenin)|interpro:IPR016024(Armadillo-type fold)|mint:Q02248|rcsb pdb:1DOW|rcsb pdb:1I7W|rcsb pdb:1I7X|rcsb pdb:1JPP|rcsb pdb:1M1E|rcsb pdb:1V18|rcsb pdb:2BCT|rcsb pdb:3BCT|rcsb pdb:3OUW|rcsb pdb:3OUX|rcsb pdb:4EV8|rcsb pdb:4EV9|rcsb pdb:4EVA|rcsb pdb:4EVP|rcsb pdb:4EVT|rcsb pdb:4ONS|reactome:R-MMU-195253|reactome:R-MMU-196299|reactome:R-MMU-201681|reactome:R-MMU-201722|reactome:R-MMU-3134973|reactome:R-MMU-351906|reactome:R-MMU-3769402|reactome:R-MMU-4086398|reactome:R-MMU-418990|reactome:R-MMU-4641262|reactome:R-MMU-5218920|reactome:R-MMU-525793|reactome:R-MMU-5626467|reactome:R-MMU-8853884|reactome:R-MMU-8951430	afcs:17026(primary-reference)|afcs:13985(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	rogid:xvyhb43JmWo6JgTE/YnFdAgvRlU10090	intact-crc:EA526B7A320C54D8|rigid:Uti3hV3PhA5ceatSord/lmD3IsY	false	sufficient binding region:1-159	sufficient binding region:512-781	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q78ZA7	uniprotkb:Q9WVS7	intact:EBI-645017|uniprotkb:O88701|ensembl:ENSMUSP00000072510	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l4_mouse(display_long)|uniprotkb:Nap1l4(gene name)|psi-mi:Nap1l4(display_short)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653504	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272418.1|refseq:NP_001272419.1|refseq:NP_032698.1|ensembl:ENSMUSG00000059119(gene)|ensembl:ENSMUST00000072727(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0030425"(dendrite)|go:"GO:0031491"(nucleosome binding)|go:"GO:0042393"(histone binding)|go:"GO:0043025"(neuronal cell body)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:Q78ZA7	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:14875(secondary-ac)	-	-	caution:The prey construct contains 4 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:wEHrLDNg3hwUMaUS8fNw0+AjBz410090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:9F68E817BE0F271C|rigid:e/qY9u92nUSIlQ7c2dvQSChbdGs	false	sufficient binding region:1-295	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64337	uniprotkb:Q9WVS7	intact:EBI-645025|uniprotkb:Q99JM8|ensembl:ENSMUSP00000099835	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:sqstm_mouse(display_long)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:STONE14(gene name synonym)|uniprotkb:Sqstm1(gene name)|psi-mi:Sqstm1(display_short)|uniprotkb:A170(gene name synonym)|uniprotkb:STAP(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653514	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277698.1|refseq:NP_035148.1|ensembl:ENSMUSG00000015837(gene)|ensembl:ENSMUST00000102774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033741|interpro:IPR034866|interpro:IPR043145|mint:Q64337|rcsb pdb:2RRU|rcsb pdb:2ZJD|rcsb pdb:3ADE|rcsb pdb:3B0F|rcsb pdb:3WDZ|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-5205685|reactome:R-MMU-9020702|reactome:R-MMU-9664873|dip:DIP-38490N	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:16512(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/BktZPkmiLsU1fKVqPSQ8ae2+SY10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:B01620C9BD62EAF9|rigid:En2oBm2XyRSl3RyGD228hwVam84	false	sufficient binding region:2-422	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64337	uniprotkb:Q9WVS7	intact:EBI-645025|uniprotkb:Q99JM8|ensembl:ENSMUSP00000099835	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:sqstm_mouse(display_long)|uniprotkb:Ubiquitin-binding protein p62(gene name synonym)|uniprotkb:STONE14(gene name synonym)|uniprotkb:Sqstm1(gene name)|psi-mi:Sqstm1(display_short)|uniprotkb:A170(gene name synonym)|uniprotkb:STAP(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653534	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001277698.1|refseq:NP_035148.1|ensembl:ENSMUSG00000015837(gene)|ensembl:ENSMUST00000102774(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0000423"(mitophagy)|go:"GO:0000932"(P-body)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002376"(immune system process)|go:"GO:0002931"(response to ischemia)|go:"GO:0003712"(transcription coregulator activity)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005770"(late endosome)|go:"GO:0005776"(autophagosome)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006914"(autophagy)|go:"GO:0006915"(apoptotic process)|go:"GO:0007032"(endosome organization)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016234"(inclusion body)|go:"GO:0016235"(aggresome)|go:"GO:0016236"(macroautophagy)|go:"GO:0016605"(PML body)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030154"(cell differentiation)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0035255"(ionotropic glutamate receptor binding)|go:"GO:0035973"(aggrephagy)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044753"(amphisome)|go:"GO:0044754"(autolysosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0061635"(regulation of protein complex stability)|go:"GO:0061912"(selective autophagy)|go:"GO:0070530"(K63-linked polyubiquitin modification-dependent protein binding)|go:"GO:0097225"(sperm midpiece)|go:"GO:0097413"(Lewy body)|go:"GO:0098780"(response to mitochondrial depolarisation)|go:"GO:1900273"(positive regulation of long-term synaptic potentiation)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1905719"(protein localization to perinuclear region of cytoplasm)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000433(Zinc finger, ZZ-type)|interpro:IPR009060(UBA-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR033741|interpro:IPR034866|interpro:IPR043145|mint:Q64337|rcsb pdb:2RRU|rcsb pdb:2ZJD|rcsb pdb:3ADE|rcsb pdb:3B0F|rcsb pdb:3WDZ|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-5205685|reactome:R-MMU-9020702|reactome:R-MMU-9664873|dip:DIP-38490N	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:16512(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/BktZPkmiLsU1fKVqPSQ8ae2+SY10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:CC4DC4F9CADAA44D|rigid:En2oBm2XyRSl3RyGD228hwVam84	false	sufficient binding region:5-276	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WTJ4	uniprotkb:Q9WVS7	intact:EBI-645044|uniprotkb:Q91W14|uniprotkb:Q9CTG3|ensembl:ENSMUSP00000076603|ensembl:ENSMUSP00000126765|ensembl:ENSMUSP00000128105|ensembl:ENSMUSP00000147011|ensembl:ENSMUSP00000147082	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:fiz1_mouse(display_long)|uniprotkb:Fiz1(gene name)|psi-mi:Fiz1(display_short)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653544	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103798.1|refseq:NP_001103799.1|refseq:NP_001103800.1|refseq:NP_035943.3|refseq:XP_006539970.1|ensembl:ENSMUSG00000061374(gene)|ensembl:ENSMUST00000077385(transcript)|ensembl:ENSMUST00000165320(transcript)|ensembl:ENSMUST00000167804(transcript)|ensembl:ENSMUST00000207030(transcript)|ensembl:ENSMUST00000208944(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9WTJ4	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17005(secondary-ac)	-	-	caution:The prey construct contains 11 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:XAqWkgbiR7Xk5/XuE+Ss0Gkxz5Q10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:6023FD17FD255889|rigid:NIsN8UKHMT99T5mXW0SgcrQ1omQ	false	sufficient binding region:1-334	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WTJ4	uniprotkb:Q9WVS7	intact:EBI-645044|uniprotkb:Q91W14|uniprotkb:Q9CTG3|ensembl:ENSMUSP00000076603|ensembl:ENSMUSP00000126765|ensembl:ENSMUSP00000128105|ensembl:ENSMUSP00000147011|ensembl:ENSMUSP00000147082	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:fiz1_mouse(display_long)|uniprotkb:Fiz1(gene name)|psi-mi:Fiz1(display_short)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653554	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001103798.1|refseq:NP_001103799.1|refseq:NP_001103800.1|refseq:NP_035943.3|refseq:XP_006539970.1|ensembl:ENSMUSG00000061374(gene)|ensembl:ENSMUST00000077385(transcript)|ensembl:ENSMUST00000165320(transcript)|ensembl:ENSMUST00000167804(transcript)|ensembl:ENSMUST00000207030(transcript)|ensembl:ENSMUST00000208944(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q9WTJ4	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17005(secondary-ac)	-	-	caution:The prey construct contains 11 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:XAqWkgbiR7Xk5/XuE+Ss0Gkxz5Q10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:674ABECF8F325B63|rigid:NIsN8UKHMT99T5mXW0SgcrQ1omQ	false	sufficient binding region:1-500	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	caution:The prey construct contains 16 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:681CDFEC5CF9DEA9|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:1-139	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653584	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17604(secondary-ac)|afcs:17026(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:96DA1C84514AB7E7|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:38-391	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653624	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:3B83A6C0005520FF|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:147-321	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653654	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:7514EAD5F8A3D0AD|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:173-391	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653704	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:A7CE2F22640E3A3B|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:180-337	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P28656	uniprotkb:Q9WVS7	intact:EBI-645055|uniprotkb:Q3UL14|ensembl:ENSMUSP00000070068|ensembl:ENSMUSP00000151750|ensembl:ENSMUSP00000151972	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:np1l1_mouse(display_long)|uniprotkb:NAP-1-related protein(gene name synonym)|uniprotkb:Brain protein DN38(gene name synonym)|uniprotkb:Nap1l1(gene name)|psi-mi:Nap1l1(display_short)|uniprotkb:Nrp(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653714	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056596.1|ensembl:ENSMUSG00000058799(gene)|ensembl:ENSMUST00000065917(transcript)|ensembl:ENSMUST00000217908(transcript)|ensembl:ENSMUST00000218828(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006334"(nucleosome assembly)|go:"GO:0019900"(kinase binding)|go:"GO:0042393"(histone binding)|go:"GO:0042470"(melanosome)|go:"GO:0043005"(neuron projection)|go:"GO:0050769"(positive regulation of neurogenesis)|go:"GO:2000179"(positive regulation of neural precursor cell proliferation)|interpro:IPR002164("Nucleosome assembly protein (NAP)")|interpro:IPR037231|mint:P28656	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17604(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AW+O1Tr5ZJ+2UVKVdK/5fqXesSs10090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:2E439B441FC74A15|rigid:ioK78XmkKgcep5ILT8CuTYP986Q	false	sufficient binding region:180-363	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JHU4	uniprotkb:Q9WVS7	intact:EBI-645061|uniprotkb:E9QM71|ensembl:ENSMUSP00000018851	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:dyhc1_mouse(display_long)|uniprotkb:Dhc1(gene name synonym)|uniprotkb:Dyhc(gene name synonym)|uniprotkb:Cytoplasmic dynein heavy chain 1(gene name synonym)|uniprotkb:Dynein heavy chain, cytosolic(gene name synonym)|uniprotkb:Dync1h1(gene name)|psi-mi:Dync1h1(display_short)|uniprotkb:Dnch1(gene name synonym)|uniprotkb:Dnchc1(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653764	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_084514.2|ensembl:ENSMUSG00000018707(gene)|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0002177"(manchette)|go:"GO:0003341"(cilium movement)|go:"GO:0005524"(ATP binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005874"(microtubule)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0005938"(cell cortex)|go:"GO:0007018"(microtubule-based movement)|go:"GO:0007097"(nuclear migration)|go:"GO:0008090"(retrograde axonal transport)|go:"GO:0008569"(minus-end-directed microtubule motor activity)|go:"GO:0030175"(filopodium)|go:"GO:0030286"(dynein complex)|go:"GO:0030424"(axon)|go:"GO:0031122"(cytoplasmic microtubule organization)|go:"GO:0032388"(positive regulation of intracellular transport)|go:"GO:0033962"(P-body assembly)|go:"GO:0034063"(stress granule assembly)|go:"GO:0043025"(neuronal cell body)|go:"GO:0045505"(dynein intermediate chain binding)|go:"GO:0051293"(establishment of spindle localization)|go:"GO:0051301"(cell division)|go:"GO:0051959"(dynein light intermediate chain binding)|go:"GO:0060236"(regulation of mitotic spindle organization)|go:"GO:0072382"(minus-end-directed vesicle transport along microtubule)|go:"GO:0090235"(regulation of metaphase plate congression)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1904115"(axon cytoplasm)|go:"GO:1905832"(positive regulation of spindle assembly)|interpro:IPR003593(AAA+ ATPase, core)|interpro:IPR004273(Dynein heavy chain)|interpro:IPR013594(Dynein heavy chain, N-terminal region 1)|interpro:IPR013602(Dynein heavy chain, N-terminal region 2)|interpro:IPR024317|interpro:IPR024743|interpro:IPR027417|interpro:IPR035699|interpro:IPR035706|interpro:IPR041228|interpro:IPR041466|interpro:IPR041658|ensembl:ENSMUST00000018851(transcript)|interpro:IPR042222|interpro:IPR042228|interpro:IPR043157|interpro:IPR043160|interpro:IPR042219|mint:Q9JHU4|rcsb pdb:3ERR|rcsb pdb:3J1T|rcsb pdb:3J1U|rcsb pdb:3WUQ|rcsb pdb:5AYH|rcsb pdb:6RZA|rcsb pdb:6RZB|reactome:R-MMU-141444|reactome:R-MMU-2132295|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-2565942|reactome:R-MMU-3371497|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5663220|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811436|reactome:R-MMU-68877|reactome:R-MMU-8854518|reactome:R-MMU-9646399|reactome:R-MMU-9648025	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:22061(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sbED0xqQpe32T7I8ijeS3Xqlx7010090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:F143F37652D0ECBD|rigid:uEAvTwMn89bOdD4Or8aOqqmTQeE	false	sufficient binding region:3363-3538	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TSH3	uniprotkb:Q9WVS7	intact:EBI-645074|ensembl:ENSMUSP00000071216|ensembl:ENSMUSP00000126629	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:zn516_mouse(display_long)|uniprotkb:Znf516(gene name)|psi-mi:Znf516(display_short)|uniprotkb:Kiaa0222(gene name synonym)|uniprotkb:Zfp516(gene name synonym)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653774	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001170935.1|refseq:NP_898854.1|refseq:XP_006526561.1|refseq:XP_006526562.1|refseq:XP_006526563.1|refseq:XP_006526564.1|refseq:XP_006526565.1|refseq:XP_006526566.1|refseq:XP_011245387.1|ensembl:ENSMUSG00000058881(gene)|ensembl:ENSMUST00000071233(transcript)|ensembl:ENSMUST00000171238(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0000987"(cis-regulatory region sequence-specific DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0009409"(response to cold)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050873"(brown fat cell differentiation)|go:"GO:0060612"(adipose tissue development)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:0140297"(DNA-binding transcription factor binding)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR036236|mint:Q7TSH3	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:17026(primary-reference)|afcs:17026(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ZHf1LTueAKPZvNSSHt1obLOPQ8010090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:CBA2D93F081F18CD|rigid:D1oxwzxHugcUv68C+0py1pUi+TE	false	sufficient binding region:945-1157	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-684233	uniprotkb:Q9WVS7	afcs:40254	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	psi-mi:big1_mouse_protein(display_short)|psi-mi:EBI-684233(display_long)	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688345	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	-	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	afcs:40254(secondary-ac)|afcs:17026(primary-reference)|afcs:40254(primary-reference)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:ADP-ribosylation factor guanine nucleotide-exchange factor 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; BIG1; P200; ARFGEP1; D130059B05Rik; D730028O18Rik|comment:"AfCS Y2H protein 40254. Sequence translated from nucleotide sequence and the full-length was deduced from the cross-reference Protein GI: 51704830."|comment:"similar to human BIG1 (97%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:QACpRgUhkx50zGB4gpb2zZezcx810090	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	intact-crc:145BBA98174B2127|rigid:lQ9x269dbTU1aMXWTFE3ZDmWsGA	false	sufficient binding region:1430-1646	sufficient binding region:1-159	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WVS7	intact:EBI-684233	intact:EBI-446144|uniprotkb:Q8CFM3|uniprotkb:Q8K360|uniprotkb:Q9D222|ensembl:ENSMUSP00000034920	afcs:40254	psi-mi:mp2k5_mouse(display_long)|uniprotkb:MAPK/ERK kinase 5(gene name synonym)|uniprotkb:Map2k5(gene name)|psi-mi:Map2k5(display_short)|uniprotkb:Mek5(gene name synonym)|uniprotkb:Mkk5(gene name synonym)|uniprotkb:Prkmk5(gene name synonym)	psi-mi:big1_mouse_protein(display_short)|psi-mi:EBI-684233(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688358	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035970.1|refseq:XP_006511208.1|ensembl:ENSMUSG00000058444(gene)|ensembl:ENSMUST00000034920(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005819"(spindle)|go:"GO:0005829"(cytosol)|go:"GO:0007507"(heart development)|go:"GO:0030307"(positive regulation of cell growth)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032717"(negative regulation of interleukin-8 production)|go:"GO:0034115"(negative regulation of heterotypic cell-cell adhesion)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051247"(positive regulation of protein metabolic process)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070375"(ERK5 cascade)|go:"GO:0071363"(cellular response to growth factor stimulus)|go:"GO:0090051"(negative regulation of cell migration involved in sprouting angiogenesis)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:2000342"("negative regulation of chemokine (C-X-C motif) ligand 2 production")|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000270(Octicosapeptide/Phox/Bem1p)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR034851|rcsb pdb:1WI0|go:"GO:0006468"(protein phosphorylation)	-	afcs:40254(secondary-ac)|afcs:17026(primary-reference)|afcs:40254(primary-reference)	-	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:ADP-ribosylation factor guanine nucleotide-exchange factor 1; brefeldin A-inhibited guanine nucleotide-exchange protein 1; BIG1; P200; ARFGEP1; D130059B05Rik; D730028O18Rik|comment:"AfCS Y2H protein 40254. Sequence translated from nucleotide sequence and the full-length was deduced from the cross-reference Protein GI: 51704830."|comment:"similar to human BIG1 (97%)"	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:9IxSvyJTcGTVoZF4jLf709Odong10090	rogid:QACpRgUhkx50zGB4gpb2zZezcx810090	intact-crc:A7A5A5807E9126A8|rigid:lQ9x269dbTU1aMXWTFE3ZDmWsGA	false	sufficient binding region:1-159	sufficient binding region:1440-1646	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P39429	uniprotkb:P39429	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655442	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:53738(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:84789CA1B42D5FD5|rigid:h7TwHYOdmbH8W5fj6F6Kqf+EfEk	false	sufficient binding region:75-373	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99M51	uniprotkb:P97820	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	intact:EBI-644181	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:m4k4_mouse(display_long)|uniprotkb:MAPK/ERK kinase kinase kinase 4(gene name synonym)|uniprotkb:HPK/GCK-like kinase HGK(gene name synonym)|uniprotkb:Nck-interacting kinase(gene name synonym)|uniprotkb:Map4k4(gene name)|psi-mi:Map4k4(display_short)|uniprotkb:Nik(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651779	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	refseq:NP_001239129.1|refseq:NP_001239130.1|refseq:NP_001239131.1|refseq:NP_032722.2|go:"GO:0120183"(positive regulation of focal adhesion disassembly)|interpro:IPR000719(Protein kinase, core)|interpro:IPR001180(Citron-like)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|reactome:R-MMU-2559580|go:"GO:0106311"|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0008017"(microtubule binding)|go:"GO:0010977"(negative regulation of neuron projection development)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0032014"(positive regulation of ARF protein signal transduction)|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048812"(neuron projection morphogenesis)|go:"GO:0051549"(positive regulation of keratinocyte migration)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0061179"(negative regulation of insulin secretion involved in cellular response to glucose stimulus)|go:"GO:0070571"(negative regulation of neuron projection regeneration)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0000165"(MAPK cascade)|go:"GO:0004111"(creatine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|dip:DIP-40973N|mint:P97820	afcs:7326(primary-reference)|afcs:55356(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	rogid:laMTX6DrOoTz4D8zxLP5ohzqKyw10090	intact-crc:519892BAB62590E9|rigid:WH7kwgnRi25Y7Ul8p+PCDAMBso4	false	sufficient binding region:1-377	sufficient binding region:465-593	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70315	uniprotkb:Q99M51	intact:EBI-644195|ensembl:ENSMUSP00000033505	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651789	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:7326(primary-reference)|afcs:10670(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:378869ABC9A30E26|rigid:U/DAQDZUfTQ+e0RPcT2VJkANwEU	false	sufficient binding region:63-221	sufficient binding region:1-377	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70315	uniprotkb:Q99M51	intact:EBI-644195|ensembl:ENSMUSP00000033505	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:wasp_mouse(display_long)|uniprotkb:Was(gene name)|psi-mi:Was(display_short)|uniprotkb:Wasp(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651799	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033541.1|ensembl:ENSMUSG00000031165(gene)|ensembl:ENSMUST00000033505(transcript)|go:"GO:0002625"(regulation of T cell antigen processing and presentation)|go:"GO:0003779"(actin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006955"(immune response)|go:"GO:0008064"(regulation of actin polymerization or depolymerization)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0010591"(regulation of lamellipodium assembly)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016197"(endosomal transport)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030041"(actin filament polymerization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031267"(small GTPase binding)|go:"GO:0032488"(Cdc42 protein signal transduction)|go:"GO:0035861"(site of double-strand break)|go:"GO:0042110"(T cell activation)|go:"GO:0042802"(identical protein binding)|go:"GO:0043274"(phospholipase binding)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0051492"(regulation of stress fiber assembly)|go:"GO:0051497"(negative regulation of stress fiber assembly)|go:"GO:0071346"(cellular response to interferon-gamma)|go:"GO:1905168"(positive regulation of double-strand break repair via homologous recombination)|go:"GO:2000146"(negative regulation of cell motility)|go:"GO:2000601"(positive regulation of Arp2/3 complex-mediated actin nucleation)|interpro:IPR000095(PAK-box/P21-Rho-binding)|interpro:IPR000697(EVH1)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011026(Wiscott-Aldrich syndrome, C-terminal)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027641|interpro:IPR033927|interpro:IPR036936|mint:P70315|dip:DIP-36426N	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:7326(primary-reference)|afcs:10670(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:HbZjGXPVByZsiabjyX43YwKnJeA10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:0DDCA138CC0D03DF|rigid:U/DAQDZUfTQ+e0RPcT2VJkANwEU	false	sufficient binding region:127-250	sufficient binding region:1-377	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P39054-2	uniprotkb:E9Q401	intact:EBI-642353|ensembl:ENSMUSP00000088616	intact:EBI-643628|ensembl:ENSMUSP00000021750|uniprotkb:O70181|uniprotkb:Q62174|uniprotkb:Q62197|uniprotkb:Q9ERN6	psi-mi:p39054-2(display_long)|uniprotkb:Dnm2(gene name)|psi-mi:Dnm2(display_short)|uniprotkb:Dyn2(gene name synonym)|uniprotkb:Dynamin UDNM(gene name synonym)	psi-mi:ryr2_mouse(display_long)|uniprotkb:Ryr2(gene name)|psi-mi:Ryr2(display_short)|uniprotkb:Cardiac muscle ryanodine receptor(gene name synonym)|uniprotkb:Cardiac muscle ryanodine receptor-calcium release channel(gene name synonym)|uniprotkb:Type 2 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651820	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-642337(dyn2_mouse)|ensembl:ENSMUSG00000033335(gene)|ensembl:ENSMUST00000091087(transcript)	refseq:NP_076357.2|go:"GO:0071872"(cellular response to epinephrine stimulus)|go:"GO:0072599"(establishment of protein localization to endoplasmic reticulum)|go:"GO:0086005"(ventricular cardiac muscle cell action potential)|go:"GO:0086029"(Purkinje myocyte to ventricular cardiac muscle cell signaling)|go:"GO:0097050"(type B pancreatic cell apoptotic process)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0071421"(manganese ion transmembrane transport)|go:"GO:0097159"(organic cyclic compound binding)|go:"GO:0098735"(positive regulation of the force of heart contraction)|go:"GO:0098904"(regulation of AV node cell action potential)|go:"GO:0098907"(regulation of SA node cell action potential)|go:"GO:0098910"(regulation of atrial cardiac muscle cell action potential)|go:"GO:0098911"(regulation of ventricular cardiac muscle cell action potential)|go:"GO:1901896"(positive regulation of ATPase-coupled calcium transmembrane transporter activity)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|interpro:IPR005821(Ion transport)|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|go:"GO:0005886"(plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0010460"(positive regulation of heart rate)|go:"GO:0010881"(regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion)|go:"GO:0010882"(regulation of cardiac muscle contraction by calcium ion signaling)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0014850"(response to muscle activity)|go:"GO:0015278"(calcium-release channel activity)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019899"(enzyme binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030017"(sarcomere)|go:"GO:0030018"(Z disc)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031672"(A band)|go:"GO:0032026"(response to magnesium ion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034220"(ion transmembrane transport)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0034237"(protein kinase A regulatory subunit binding)|go:"GO:0034704"(calcium channel complex)|go:"GO:0035584"(calcium-mediated signaling using intracellular calcium source)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0042383"(sarcolemma)|go:"GO:0042802"(identical protein binding)|go:"GO:0043005"(neuron projection)|go:"GO:0043621"(protein self-association)|go:"GO:0043924"(suramin binding)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051284"(positive regulation of sequestering of calcium ion)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051592"(response to calcium ion)|go:"GO:0051775"(response to redox state)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0060048"(cardiac muscle contraction)|go:"GO:0060401"(cytosolic calcium ion transport)|go:"GO:0060402"(calcium ion transport into cytosol)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0070588"(calcium ion transmembrane transport)|go:"GO:0071313"(cellular response to caffeine)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|rcsb pdb:4ETV|rcsb pdb:4KEI|rcsb pdb:4KEJ|rcsb pdb:4KEK|rcsb pdb:4L4H|interpro:IPR013333(Ryanodine receptor, N-terminal)|rcsb pdb:4L4I|rcsb pdb:4P9I|interpro:IPR013662(RyR and IP3R Homology associated)|rcsb pdb:4P9L|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|rcsb pdb:5C33|rcsb pdb:5VSN|rcsb pdb:6J6L|rcsb pdb:6MM5|rcsb pdb:6MM6|rcsb pdb:6MM7|interpro:IPR016093(MIR motif)|rcsb pdb:6MM8|interpro:IPR035761|rcsb pdb:6WOU|rcsb pdb:6WOV|reactome:R-MMU-2672351|interpro:IPR035762|reactome:R-MMU-5578775|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|mint:E9Q401|rcsb pdb:2MC2|rcsb pdb:3IM5|rcsb pdb:3IM6|rcsb pdb:3IM7|rcsb pdb:3QR5|ensembl:ENSMUSG00000021313(gene)|ensembl:ENSMUST00000021750(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002027"(regulation of heart rate)|go:"GO:0003143"(embryonic heart tube morphogenesis)|go:"GO:0003220"(left ventricular cardiac muscle tissue morphogenesis)|go:"GO:0003300"(cardiac muscle hypertrophy)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005790"(smooth endoplasmic reticulum)	afcs:24653(primary-reference)|afcs:14203(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:erJ4QqPwOjhyjX7e5ST4NEus3lo10090	rogid:HHxj8k5HJe0bbt0o041H0inQo0w10090	intact-crc:BE170BF311A8732D|rigid:hmFQcV5LYwBLbBip6UhMZ+wC90Y	false	sufficient binding region:823-866	sufficient binding region:4799-4960	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:B9EKI5	uniprotkb:Q99M51	intact:EBI-682463|ensembl:ENSMUSP00000110115|ensembl:ENSMUSP00000154583	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:b9eki5_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688279	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028410.1|refseq:XP_006522014.1|ensembl:ENSMUSG00000022637(gene)|ensembl:ENSMUST00000114471(transcript)|ensembl:ENSMUST00000227062(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023051"(regulation of signaling)|go:"GO:0047690"(aspartyltransferase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:20358(secondary-ac)|afcs:7326(primary-reference)|afcs:35574(primary-reference)	comment:"AfCS Y2H protein 20358. Sequence deduced from cross-reference: protein GI: 20894431, replaced by protein GI: 51769670."|comment:"similat to rat Casitas B-lineage lymphoma b; Cbl-b protein (98%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/a/ZrHmGa1+dJMyubsxdzGfCrdQ10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:E39EB78168CCAAA7|rigid:DyprUSyzzO73EpILdLrtGHr324c	false	sufficient binding region:213-289	sufficient binding region:1-377	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q09163	uniprotkb:Q62406-1	intact:EBI-646470|uniprotkb:Q07645|uniprotkb:Q62208	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:dlk1_mouse(display_long)|uniprotkb:Preadipocyte factor 1(gene name synonym)|uniprotkb:Adipocyte differentiation inhibitor protein(gene name synonym)|uniprotkb:Dlk1(gene name)|psi-mi:Dlk1(display_short)|uniprotkb:Dlk(gene name synonym)|uniprotkb:Pref1(gene name synonym)|uniprotkb:Scp-1(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656238	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034182.2|dip:DIP-6010N|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030282"(bone mineralization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:12588(secondary-ac)	-	-	caution:The prey construct contains 8 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LlVT6V8bZp5yYAxg9litO6uvziw10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:F25C6F729DE8C981|rigid:LEw5VlJWMwW8IaHj7Yj2Fgxghhc	false	sufficient binding region:1-289	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q62406-1	uniprotkb:P37889-1	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	intact:EBI-645953|ensembl:ENSMUSP00000048334	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656268	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	afcs:14620(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	intact-crc:3772D6879026C1D3|rigid:/vAILo4zesG8yEikADQz1kvVntI	false	sufficient binding region:433-710	sufficient binding region:967-1221	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37889-1	uniprotkb:Q62406-1	intact:EBI-645953|ensembl:ENSMUSP00000048334	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656288	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:3F6E8C63C3B40AF4|rigid:/vAILo4zesG8yEikADQz1kvVntI	false	sufficient binding region:1018-1221	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37889-1	uniprotkb:Q62406-1	intact:EBI-645953|ensembl:ENSMUSP00000048334	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656308	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:92900DAFD4380E75|rigid:/vAILo4zesG8yEikADQz1kvVntI	false	sufficient binding region:1037-1221	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37889-1	uniprotkb:Q62406-1	intact:EBI-645953|ensembl:ENSMUSP00000048334	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656318	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:8834B3026A103432|rigid:/vAILo4zesG8yEikADQz1kvVntI	false	sufficient binding region:1054-1221	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O35459	uniprotkb:Q62406-1	intact:EBI-646510|uniprotkb:Q5M8P6|ensembl:ENSMUSP00000066092	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:ech1_mouse(display_long)|uniprotkb:Ech1(gene name)|psi-mi:Ech1(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656368	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_058052.1|ensembl:ENSMUSG00000053898(gene)|ensembl:ENSMUST00000066264(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005777"(peroxisome)|go:"GO:0006635"(fatty acid beta-oxidation)|interpro:IPR001753(Crotonase, core)|interpro:IPR014748(Crontonase, C-terminal)|interpro:IPR018376|interpro:IPR029045|mint:O35459|reactome:R-MMU-9033241|go:"GO:0051750"("delta(3,5)-delta(2,4)-dienoyl-CoA isomerase activity")	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:17730(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FSiH0dZUTf0WqDSQ8otpzG5WOMY10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:8E2A661B2454EBBE|rigid:d+Y3/flbDB/vyTBWEYmSP/s+w0c	false	sufficient binding region:64-300	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K2C1	uniprotkb:Q62406-1	intact:EBI-646567	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:q8k2c1_mouse(display_long)|uniprotkb:Aamp(gene name)|psi-mi:Aamp(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656388	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR001680(WD40 repeat)|interpro:IPR019775|interpro:IPR036322|go:"GO:0005829"(cytosol)|go:"GO:0008201"(heparin binding)|go:"GO:0009986"(cell surface)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0045171"(intercellular bridge)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:53888(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:aZBaabESPMppJO3EsKT91pH8Yd010090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:EED2ACC5302D5333|rigid:fE+428agylSt0IaHFLCZFBsOhXI	false	sufficient binding region:26-344	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3THG9	uniprotkb:Q62406-1	intact:EBI-646572|uniprotkb:Q3UWH8|uniprotkb:Q8BVJ6|uniprotkb:Q99JS9|ensembl:ENSMUSP00000067912	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:aasd1_mouse(display_long)|uniprotkb:Aarsd1(gene name)|psi-mi:Aarsd1(display_short)|uniprotkb:Alax(gene name synonym)|uniprotkb:Alanyl-tRNA deacylase alaX(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656408	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659078.1|ensembl:ENSMUST00000070395(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR018165|mint:Q3THG9|ensembl:ENSMUSG00000075528(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:55462(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LOhCc9VYhW33LcVAjKY7U5mBxG010090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:3610F3BA52D6B824|rigid:TTlbLetSO6InReymD4LD/BGv5zE	false	sufficient binding region:89-356	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3THG9	uniprotkb:Q62406-1	intact:EBI-646572|uniprotkb:Q3UWH8|uniprotkb:Q8BVJ6|uniprotkb:Q99JS9|ensembl:ENSMUSP00000067912	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:aasd1_mouse(display_long)|uniprotkb:Aarsd1(gene name)|psi-mi:Aarsd1(display_short)|uniprotkb:Alax(gene name synonym)|uniprotkb:Alanyl-tRNA deacylase alaX(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656418	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659078.1|ensembl:ENSMUST00000070395(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR018165|mint:Q3THG9|ensembl:ENSMUSG00000075528(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:55462(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LOhCc9VYhW33LcVAjKY7U5mBxG010090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:BFF1D5BA0CE2C38D|rigid:TTlbLetSO6InReymD4LD/BGv5zE	false	sufficient binding region:89-412	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91YU6	uniprotkb:P39429	intact:EBI-646581|uniprotkb:E9QKK6|uniprotkb:Q569X6|ensembl:ENSMUSP00000045478|ensembl:ENSMUSP00000136405|ensembl:ENSMUSP00000137571	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:lzts2_mouse(display_long)|uniprotkb:Lzts2(gene name)|psi-mi:Lzts2(display_short)|uniprotkb:Kiaa1813(gene name synonym)|uniprotkb:Lapser1(gene name synonym)|uniprotkb:Protein LAPSER1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656448	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123997.1|refseq:NP_001123998.1|refseq:NP_663478.2|refseq:XP_006527067.1|ensembl:ENSMUSG00000035342(gene)|ensembl:ENSMUST00000039016(transcript)|ensembl:ENSMUST00000178087(transcript)|ensembl:ENSMUST00000179108(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001822"(kidney development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:54901(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8vF1Urk1kDHDPcvi4VqWQyRbxig10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:BD8B0B7F1FDE9B7C|rigid:4HA5vboSq2acUBfq3HCxLukiNI0	false	sufficient binding region:348-562	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91YU6	uniprotkb:P39429	intact:EBI-646581|uniprotkb:E9QKK6|uniprotkb:Q569X6|ensembl:ENSMUSP00000045478|ensembl:ENSMUSP00000136405|ensembl:ENSMUSP00000137571	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:lzts2_mouse(display_long)|uniprotkb:Lzts2(gene name)|psi-mi:Lzts2(display_short)|uniprotkb:Kiaa1813(gene name synonym)|uniprotkb:Lapser1(gene name synonym)|uniprotkb:Protein LAPSER1(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656458	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001123997.1|refseq:NP_001123998.1|refseq:NP_663478.2|refseq:XP_006527067.1|ensembl:ENSMUSG00000035342(gene)|ensembl:ENSMUST00000039016(transcript)|ensembl:ENSMUST00000178087(transcript)|ensembl:ENSMUST00000179108(transcript)|go:"GO:0000281"(mitotic cytokinesis)|go:"GO:0001822"(kidney development)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005874"(microtubule)|go:"GO:0005886"(plasma membrane)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010942"(positive regulation of cell death)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030496"(midbody)|go:"GO:0031982"(vesicle)|go:"GO:0051013"(microtubule severing)|go:"GO:0051168"(nuclear export)|go:"GO:0051255"(spindle midzone assembly)|go:"GO:0060682"(primary ureteric bud growth)|go:"GO:0072197"(ureter morphogenesis)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:1900181"(negative regulation of protein localization to nucleus)|interpro:IPR028597	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:54901(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8vF1Urk1kDHDPcvi4VqWQyRbxig10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:A22AD3A5D7FEEC7B|rigid:4HA5vboSq2acUBfq3HCxLukiNI0	false	sufficient binding region:375-591	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z2V4	uniprotkb:Q62120	intact:EBI-646627|uniprotkb:Q3UEH3|ensembl:ENSMUSP00000029017	intact:EBI-646604|uniprotkb:Q7TQD0|uniprotkb:Q62124|intact:EBI-16039126|ensembl:ENSMUSP00000025705|ensembl:ENSMUSP00000064394|ensembl:ENSMUSP00000158242|uniprotkb:G5E852	psi-mi:pckgc_mouse(display_long)|uniprotkb:Pck1(gene name)|psi-mi:Pck1(display_short)|uniprotkb:Pepck(gene name synonym)|uniprotkb:Serine-protein kinase PCK1(gene name synonym)	psi-mi:jak2_mouse(display_long)|uniprotkb:Janus kinase 2(gene name synonym)|uniprotkb:Jak2(gene name)|psi-mi:Jak2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656539	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035174.1|ensembl:ENSMUSG00000027513(gene)|ensembl:ENSMUST00000029017(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004611"(phosphoenolpyruvate carboxykinase activity)|go:"GO:0004613"("phosphoenolpyruvate carboxykinase (GTP) activity")|go:"GO:0005525"(GTP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006094"(gluconeogenesis)|go:"GO:0006107"(oxaloacetate metabolic process)|go:"GO:0005739"(mitochondrion)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0007568"(aging)|go:"GO:0009617"(response to bacterium)|go:"GO:0014823"(response to activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019003"(GDP binding)|go:"GO:0019543"(propionate catabolic process)|go:"GO:0030145"(manganese ion binding)|go:"GO:0031406"(carboxylic acid binding)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032868"(response to insulin)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0033993"(response to lipid)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042594"(response to starvation)|go:"GO:0043382"(positive regulation of memory T cell differentiation)|go:"GO:0046327"(glycerol biosynthetic process from pyruvate)|go:"GO:0046890"(regulation of lipid biosynthetic process)|go:"GO:0051365"(cellular response to potassium ion starvation)|go:"GO:0061402"(positive regulation of transcription from RNA polymerase II promoter in response to acidic pH)|go:"GO:0070365"(hepatocyte differentiation)|go:"GO:0070741"(response to interleukin-6)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071332"(cellular response to fructose stimulus)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071377"(cellular response to glucagon stimulus)|go:"GO:0071456"(cellular response to hypoxia)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0106264"("protein serine kinase activity (using GTP as donor)")|go:"GO:1904640"(response to methionine)|interpro:IPR008209(Phosphoenolpyruvate carboxykinase, GTP-utilising)|interpro:IPR008210(Phosphoenolpyruvate carboxykinase, N-terminal)|interpro:IPR013035(Phosphoenolpyruvate carboxykinase, C-terminal)|interpro:IPR018091|interpro:IPR035077|interpro:IPR035078|reactome:R-MMU-70263	refseq:NP_001041642.1|refseq:NP_032439.2|dip:DIP-320N|ensembl:ENSMUSG00000024789(gene)|ensembl:ENSMUST00000025705(transcript)|ensembl:ENSMUST00000065796(transcript)|ensembl:ENSMUST00000238009(transcript)|go:"GO:0000186"(obsolete activation of MAPKK activity)|go:"GO:0000791"(euchromatin)|go:"GO:0001774"(microglial cell activation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050867"(positive regulation of cell activation)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0060333"(interferon-gamma-mediated signaling pathway)|go:"GO:0060391"(positive regulation of SMAD protein signal transduction)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060399"(positive regulation of growth hormone receptor signaling pathway)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061180"(mammary gland epithelium development)|go:"GO:0070671"(response to interleukin-12)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071549"(cellular response to dexamethasone stimulus)|go:"GO:0097012"(response to granulocyte macrophage colony-stimulating factor)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0097296"(activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1904037"(positive regulation of epithelial cell apoptotic process)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2001235"(positive regulation of apoptotic signaling pathway)|interpro:IPR000299(Band 4.1, N-terminal)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR016251(Tyrosine-protein kinase, Jak/Tyk2)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|go:"GO:0098794"(postsynapse)|interpro:IPR019749|go:"GO:0022408"(negative regulation of cell-cell adhesion)|go:"GO:0030099"(myeloid cell differentiation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031103"(axon regeneration)|go:"GO:0031702"(type 1 angiotensin receptor binding)|go:"GO:0031959"(mineralocorticoid receptor signaling pathway)|go:"GO:0032024"(positive regulation of insulin secretion)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0033130"(acetylcholine receptor binding)|go:"GO:0033194"(response to hydroperoxide)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0020037"(heme binding)|interpro:IPR020693|interpro:IPR035588|interpro:IPR035589|interpro:IPR035860|interpro:IPR035963|interpro:IPR036860|interpro:IPR037838|interpro:IPR041046|interpro:IPR041155|interpro:IPR041381|mint:Q62120|rcsb pdb:2HDX|rcsb pdb:4GL9|reactome:R-MMU-1059683|reactome:R-MMU-110056|interpro:IPR020635|reactome:R-MMU-112411|reactome:R-MMU-1170546|go:"GO:0034612"(response to tumor necrosis factor)|go:"GO:0035166"(post-embryonic hemopoiesis)|go:"GO:0035401"("histone kinase activity (H3-Y41 specific)")|go:"GO:0035409"(histone H3-Y41 phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035722"(interleukin-12-mediated signaling pathway)|go:"GO:0036016"(cellular response to interleukin-3)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042393"(histone binding)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042802"(identical protein binding)|go:"GO:0042976"(activation of Janus kinase activity)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0034050"(programmed cell death induced by symbiont)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005131"(growth hormone receptor binding)|go:"GO:0005143"(interleukin-12 receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005730"(nucleolus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007167"(enzyme linked receptor protein signaling pathway)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0006979"(response to oxidative stress)|go:"GO:0007165"(signal transduction)|reactome:R-MMU-512988|reactome:R-MMU-5673000|reactome:R-MMU-5673001|reactome:R-MMU-6785807|reactome:R-MMU-6788467|reactome:R-MMU-69231|reactome:R-MMU-877300|reactome:R-MMU-877312|reactome:R-MMU-8854691|reactome:R-MMU-8984722|reactome:R-MMU-9020591|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912526|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|reactome:R-MMU-983231|reactome:R-MMU-1433557|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007204"(positive regulation of cytosolic calcium ion concentration)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007260"(tyrosine phosphorylation of STAT protein)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008631"(intrinsic apoptotic signaling pathway in response to oxidative stress)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0012505"(endomembrane system)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0043392"(negative regulation of DNA binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045348"(positive regulation of MHC class II biosynthetic process)|go:"GO:0045428"(regulation of nitric oxide biosynthetic process)|go:"GO:0045429"(positive regulation of nitric oxide biosynthetic process)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045822"(negative regulation of heart contraction)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046677"(response to antibiotic)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0043388"(positive regulation of DNA binding)|dip:DIP-60238N|refseq:XP_011245457.1	afcs:55384(primary-reference)|afcs:16531(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2021/02/15	rogid:z9qhjxhtVgO2h4voODVUW/661E010090	rogid:pdjCNCHmNTiJ1gGtJyiWoGgtq4I10090	intact-crc:9DB08F6E49937B8B|rigid:lIibMMmYYAFaJc5S4BIdAv6WxXg	false	sufficient binding region:348-620	sufficient binding region:800-1125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97447-1	uniprotkb:Q9WTQ5	intact:EBI-643787|ensembl:ENSMUSP00000023854|ensembl:ENSMUSP00000112295|intact:EBI-7485892|intact:MINT-1326991	intact:EBI-643771|uniprotkb:Q80SS4|uniprotkb:Q8BPK4|uniprotkb:Q99MP1|uniprotkb:Q810D4|ensembl:ENSMUSP00000035829	psi-mi:p97447-1(display_long)|uniprotkb:KyoT1(isoform synonym)|uniprotkb:Fhl1(gene name)|psi-mi:Fhl1(display_short)|uniprotkb:KyoT(gene name synonym)|uniprotkb:RBP-associated molecule 14-1(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 1(gene name synonym)	psi-mi:aka12_mouse(display_long)|uniprotkb:Ssecks(gene name synonym)|uniprotkb:Src-suppressed C kinase substrate(gene name synonym)|uniprotkb:Germ cell lineage protein gercelin(gene name synonym)|uniprotkb:Akap12(gene name)|psi-mi:Akap12(display_short)|uniprotkb:Gag12(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651435	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-643780(fhl1_mouse)|ensembl:ENSMUSG00000023092(gene)|ensembl:ENSMUST00000023854(transcript)|ensembl:ENSMUST00000116596(transcript)	refseq:NP_112462.1|ensembl:ENSMUSG00000038587(gene)|ensembl:ENSMUST00000045730(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061870"(positive regulation of hepatic stellate cell migration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090036"(regulation of protein kinase C signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1900143"(positive regulation of oligodendrocyte apoptotic process)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR018459|interpro:IPR028540|mint:Q9WTQ5|reactome:R-MMU-9013405|reactome:R-MMU-9035034	afcs:21848(primary-reference)|afcs:12021(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:aRTinreahM4oHvZJgLx9Wf0t89E10090	rogid:RXRSkp9BL27+a/XTM8s7aTaXrMc10090	intact-crc:1B893DDD46DFE632|rigid:hxEUD2ejM+KaMqkwooA/QxyOlMo	false	sufficient binding region:107-280	sufficient binding region:800-1151	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97447-1	uniprotkb:Q9WTQ5	intact:EBI-643787|ensembl:ENSMUSP00000023854|ensembl:ENSMUSP00000112295|intact:EBI-7485892|intact:MINT-1326991	intact:EBI-643771|uniprotkb:Q80SS4|uniprotkb:Q8BPK4|uniprotkb:Q99MP1|uniprotkb:Q810D4|ensembl:ENSMUSP00000035829	psi-mi:p97447-1(display_long)|uniprotkb:KyoT1(isoform synonym)|uniprotkb:Fhl1(gene name)|psi-mi:Fhl1(display_short)|uniprotkb:KyoT(gene name synonym)|uniprotkb:RBP-associated molecule 14-1(gene name synonym)|uniprotkb:Skeletal muscle LIM-protein 1(gene name synonym)	psi-mi:aka12_mouse(display_long)|uniprotkb:Ssecks(gene name synonym)|uniprotkb:Src-suppressed C kinase substrate(gene name synonym)|uniprotkb:Germ cell lineage protein gercelin(gene name synonym)|uniprotkb:Akap12(gene name)|psi-mi:Akap12(display_short)|uniprotkb:Gag12(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651446	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-643780(fhl1_mouse)|ensembl:ENSMUSG00000023092(gene)|ensembl:ENSMUST00000023854(transcript)|ensembl:ENSMUST00000116596(transcript)	refseq:NP_112462.1|ensembl:ENSMUSG00000038587(gene)|ensembl:ENSMUST00000045730(transcript)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007193"(adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway)|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0010739"(positive regulation of protein kinase A signaling)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0035733"(hepatic stellate cell activation)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043116"(negative regulation of vascular permeability)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051018"(protein kinase A binding)|go:"GO:0051602"(response to electrical stimulus)|go:"GO:0051770"(positive regulation of nitric-oxide synthase biosynthetic process)|go:"GO:0061870"(positive regulation of hepatic stellate cell migration)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|go:"GO:0071347"(cellular response to interleukin-1)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0090036"(regulation of protein kinase C signaling)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:1900143"(positive regulation of oligodendrocyte apoptotic process)|interpro:IPR001573(Protein kinase A anchoring region)|interpro:IPR018459|interpro:IPR028540|mint:Q9WTQ5|reactome:R-MMU-9013405|reactome:R-MMU-9035034	afcs:21848(primary-reference)|afcs:12021(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:aRTinreahM4oHvZJgLx9Wf0t89E10090	rogid:RXRSkp9BL27+a/XTM8s7aTaXrMc10090	intact-crc:2372A2CE22BAC7BF|rigid:hxEUD2ejM+KaMqkwooA/QxyOlMo	false	sufficient binding region:139-280	sufficient binding region:800-1151	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q60749	uniprotkb:P39688	intact:EBI-519077|uniprotkb:A2ACH3|uniprotkb:Q7M4N5|uniprotkb:Q3U8T3|uniprotkb:Q60735|uniprotkb:Q99M33|ensembl:ENSMUSP00000066516|ensembl:ENSMUSP00000115402|uniprotkb:B2KG38	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:khdr1_mouse(display_long)|uniprotkb:p21 Ras GTPase-activating protein-associated p62(gene name synonym)|uniprotkb:GAP-associated tyrosine phosphoprotein p62(gene name synonym)|uniprotkb:Src-associated in mitosis 68 kDa protein(gene name synonym)|uniprotkb:p68(gene name synonym)|uniprotkb:Khdrbs1(gene name)|psi-mi:Khdrbs1(display_short)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648389	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000028790(gene)|ensembl:ENSMUST00000066257(transcript)|ensembl:ENSMUST00000129342(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000381"(regulation of alternative mRNA splicing, via spliceosome)|go:"GO:0003723"(RNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006397"(mRNA processing)|go:"GO:0007049"(cell cycle)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007283"(spermatogenesis)|go:"GO:0008143"("poly(A) binding")|go:"GO:0008266"("poly(U) RNA binding")|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045948"(positive regulation of translational initiation)|go:"GO:0046831"(regulation of RNA export from nucleus)|go:"GO:0046833"(positive regulation of RNA export from nucleus)|go:"GO:0048024"(regulation of mRNA splicing, via spliceosome)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0070618"(Grb2-Sos complex)|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR004087(K Homology)|interpro:IPR004088(K Homology, type 1)|interpro:IPR032335|interpro:IPR032571|interpro:IPR036612|mint:Q60749|reactome:R-MMU-8849468|refseq:NP_035447.3|dip:DIP-2861N	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:6614(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FtKudvPZeoFATHi0fUbnPsJgons10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:5C735AEACC300076|rigid:9F5SbbSPce/+uzYf9jIoGfMCYGE	false	sufficient binding region:131-377	sufficient binding region:2-146	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51807	uniprotkb:P35329-1	intact:EBI-642797|uniprotkb:Q5M8S6|ensembl:ENSMUSP00000137171|ensembl:ENSMUSP00000135978|ensembl:ENSMUSP00000090644|ensembl:ENSMUSP00000127990	intact:EBI-432391	psi-mi:dylt1_mouse(display_long)|uniprotkb:T-complex testis-specific protein 1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym)|uniprotkb:Tctex1(gene name synonym)|uniprotkb:Tctex-1(gene name synonym)|uniprotkb:Dynlt1(gene name)|psi-mi:Dynlt1(display_short)|uniprotkb:Activator of G-protein signaling 2(gene name synonym)|uniprotkb:Tctel1(gene name synonym)	psi-mi:p35329-1(display_long)|uniprotkb:CD22-beta(isoform synonym)|uniprotkb:Cd22(gene name)|psi-mi:Cd22(display_short)|uniprotkb:Lyb-8(gene name synonym)|uniprotkb:Siglec2(gene name synonym)|uniprotkb:B-lymphocyte cell adhesion molecule(gene name synonym)|uniprotkb:Sialic acid-binding Ig-like lectin 2(gene name synonym)|uniprotkb:T-cell surface antigen Leu-14(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653406	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001160099.1|refseq:NP_001160101.1|refseq:NP_001160102.1|refseq:NP_033368.1|ensembl:ENSMUST00000092966(transcript)|ensembl:ENSMUST00000169415(transcript)|ensembl:ENSMUST00000179554(transcript)|ensembl:ENSMUST00000179569(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0099503"(secretory vesicle)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|mint:P51807|rcsb pdb:5WI4|reactome:R-MMU-6798695|go:"GO:0030742"(GTP-dependent protein binding)|ensembl:ENSMUSG00000000579(gene)|ensembl:ENSMUSG00000092074(gene)|ensembl:ENSMUSG00000095677(gene)|ensembl:ENSMUSG00000096255(gene)|refseq:XP_017172676.1	intact:EBI-300059(cd22_mouse)	afcs:9401(secondary-ac)|afcs:15793(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fn6QN4J3aA++93iJwG3rFDjPBvM10090	rogid:G3TJTROpwehqmpb+7OjLe3e+YCc10090	intact-crc:A22A2E5AA3C7016A|rigid:KM05JC/085vR6YcF1r8LrBQ8G9E	false	sufficient binding region:1-113	sufficient binding region:136-341	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51807	uniprotkb:P39688	intact:EBI-642797|uniprotkb:Q5M8S6|ensembl:ENSMUSP00000137171|ensembl:ENSMUSP00000135978|ensembl:ENSMUSP00000090644|ensembl:ENSMUSP00000127990	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:dylt1_mouse(display_long)|uniprotkb:T-complex testis-specific protein 1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym)|uniprotkb:Tctex1(gene name synonym)|uniprotkb:Tctex-1(gene name synonym)|uniprotkb:Dynlt1(gene name)|psi-mi:Dynlt1(display_short)|uniprotkb:Activator of G-protein signaling 2(gene name synonym)|uniprotkb:Tctel1(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653416	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001160099.1|refseq:NP_001160101.1|refseq:NP_001160102.1|refseq:NP_033368.1|ensembl:ENSMUST00000092966(transcript)|ensembl:ENSMUST00000169415(transcript)|ensembl:ENSMUST00000179554(transcript)|ensembl:ENSMUST00000179569(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0099503"(secretory vesicle)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|mint:P51807|rcsb pdb:5WI4|reactome:R-MMU-6798695|go:"GO:0030742"(GTP-dependent protein binding)|ensembl:ENSMUSG00000000579(gene)|ensembl:ENSMUSG00000092074(gene)|ensembl:ENSMUSG00000095677(gene)|ensembl:ENSMUSG00000096255(gene)|refseq:XP_017172676.1	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:52691(primary-reference)|afcs:9401(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fn6QN4J3aA++93iJwG3rFDjPBvM10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:5614D1A36AD72FB9|rigid:jhHT445UrXIn2xRjN6t7m27AtE0	false	sufficient binding region:1-113	sufficient binding region:2-146	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51807	uniprotkb:P39688	intact:EBI-642797|uniprotkb:Q5M8S6|ensembl:ENSMUSP00000137171|ensembl:ENSMUSP00000135978|ensembl:ENSMUSP00000090644|ensembl:ENSMUSP00000127990	intact:EBI-524514|uniprotkb:Q3TAT3|uniprotkb:Q3U0T5|uniprotkb:Q8K2A3|ensembl:ENSMUSP00000097547	psi-mi:dylt1_mouse(display_long)|uniprotkb:T-complex testis-specific protein 1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym)|uniprotkb:Tctex1(gene name synonym)|uniprotkb:Tctex-1(gene name synonym)|uniprotkb:Dynlt1(gene name)|psi-mi:Dynlt1(display_short)|uniprotkb:Activator of G-protein signaling 2(gene name synonym)|uniprotkb:Tctel1(gene name synonym)	psi-mi:fyn_mouse(display_long)|uniprotkb:p59-Fyn(gene name synonym)|uniprotkb:Fyn(gene name)|psi-mi:Fyn(display_short)|uniprotkb:Proto-oncogene c-Fyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653434	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001160099.1|refseq:NP_001160101.1|refseq:NP_001160102.1|refseq:NP_033368.1|ensembl:ENSMUST00000092966(transcript)|ensembl:ENSMUST00000169415(transcript)|ensembl:ENSMUST00000179554(transcript)|ensembl:ENSMUST00000179569(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0099503"(secretory vesicle)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|mint:P51807|rcsb pdb:5WI4|reactome:R-MMU-6798695|go:"GO:0030742"(GTP-dependent protein binding)|ensembl:ENSMUSG00000000579(gene)|ensembl:ENSMUSG00000092074(gene)|ensembl:ENSMUSG00000095677(gene)|ensembl:ENSMUSG00000096255(gene)|refseq:XP_017172676.1	ensembl:ENSMUSG00000019843(gene)|ensembl:ENSMUST00000099967(transcript)|go:"GO:0000304"(response to singlet oxygen)|go:"GO:0001664"(G protein-coupled receptor binding)|go:"GO:0001764"(neuron migration)|go:"GO:0002250"(adaptive immune response)|go:"GO:0003015"(heart process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005739"(mitochondrion)|go:"GO:0005768"(endosome)|go:"GO:0005829"(cytosol)|go:"GO:0005884"(actin filament)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008360"(regulation of cell shape)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0050730"(regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050798"(activated T cell proliferation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050966"(detection of mechanical stimulus involved in sensory perception of pain)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0070851"(growth factor receptor binding)|go:"GO:0071375"(cellular response to peptide hormone stimulus)|go:"GO:0071560"(cellular response to transforming growth factor beta stimulus)|go:"GO:0071944"(cell periphery)|go:"GO:0090314"(positive regulation of protein targeting to membrane)|go:"GO:0097038"(perinuclear endoplasmic reticulum)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0097386"(glial cell projection)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042552"(myelination)|go:"GO:0042608"(T cell receptor binding)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0042610"(CD8 receptor binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043014"(alpha-tubulin binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0044297"(cell body)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045471"(response to ethanol)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048156"(tau protein binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0015631"(tubulin binding)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016020"(membrane)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0019899"(enzyme binding)|go:"GO:0030154"(cell differentiation)|go:"GO:0030425"(dendrite)|go:"GO:0030900"(forebrain development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031397"(negative regulation of protein ubiquitination)|go:"GO:0031802"(type 5 metabotropic glutamate receptor binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0036120"(cellular response to platelet-derived growth factor stimulus)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042493"|go:"GO:0014069"(postsynaptic density)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035750|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099092"(postsynaptic density, intracellular component)|go:"GO:1900182"(positive regulation of protein localization to nucleus)|go:"GO:1900449"(regulation of glutamate receptor signaling pathway)|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1902951"(negative regulation of dendritic spine maintenance)|go:"GO:1903202"(negative regulation of oxidative stress-induced cell death)|go:"GO:1904645"(response to amyloid-beta)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1905232"(cellular response to L-glutamate)|go:"GO:1905430"(cellular response to glycine)|go:"GO:1905664"(regulation of calcium ion import across plasma membrane)|go:"GO:2001056"(positive regulation of cysteine-type endopeptidase activity)|go:"GO:2001240"(negative regulation of extrinsic apoptotic signaling pathway in absence of ligand)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|interpro:IPR036028|mint:P39688|rcsb pdb:3UF4|interpro:IPR036860|reactome:R-MMU-114604|reactome:R-MMU-1227986|reactome:R-MMU-1257604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2424491|reactome:R-MMU-373753|reactome:R-MMU-375165|reactome:R-MMU-389356|reactome:R-MMU-389357|reactome:R-MMU-389359|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928664|reactome:R-MMU-3928665|reactome:R-MMU-399954|reactome:R-MMU-399955|reactome:R-MMU-399956|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5673001|reactome:R-MMU-6811558|reactome:R-MMU-75892|reactome:R-MMU-8866376|reactome:R-MMU-9032759|reactome:R-MMU-912631|refseq:NP_001116364.1|refseq:NP_001116365.1|refseq:NP_032080.2|refseq:XP_006512602.1|refseq:XP_006512603.1|refseq:XP_011241419.1|dip:DIP-198N	afcs:9401(secondary-ac)|afcs:52691(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fn6QN4J3aA++93iJwG3rFDjPBvM10090	rogid:QVU98HrNOdxdJIzSvFWdhZ914MQ10090	intact-crc:1069A457074322EC|rigid:jhHT445UrXIn2xRjN6t7m27AtE0	false	sufficient binding region:1-113	sufficient binding region:144-267	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CQB4	uniprotkb:Q9DBC7	intact:EBI-645694|ensembl:ENSMUSP00000021993	intact:EBI-645677|uniprotkb:Q3UKU7|uniprotkb:Q9JHR5|uniprotkb:Q9JHR6|ensembl:ENSMUSP00000056500|ensembl:ENSMUSP00000102288	psi-mi:q9cqb4_mouse(display_long)|uniprotkb:Uqcrb(gene name)|psi-mi:Uqcrb(display_short)	psi-mi:kap0_mouse(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654629	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080495.1|ensembl:ENSMUSG00000021520(gene)|ensembl:ENSMUST00000021993(transcript)|go:"GO:0005750"(mitochondrial respiratory chain complex III)|go:"GO:0006122"(mitochondrial electron transport, ubiquinol to cytochrome c)|interpro:IPR003197(Cytochrome bd ubiquinol oxidase, 14 kDa subunit)|interpro:IPR036544|mint:Q9CQB4	refseq:NP_001300902.1|refseq:NP_001300903.1|refseq:NP_001300904.1|refseq:NP_001300905.1|refseq:NP_068680.1|refseq:XP_017169829.1|dip:DIP-32450N|ensembl:ENSMUSG00000020612(gene)|ensembl:ENSMUST00000049527(transcript)|ensembl:ENSMUST00000106677(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-983231|reactome:R-MMU-5610787|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:Q9DBC7|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|go:"GO:0043949"(regulation of cAMP-mediated signaling)|reactome:R-MMU-442720	afcs:20225(primary-reference)|afcs:30364(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uqZtpTGJVDAe85rBGuVC25bujMs10090	rogid:0KqlQxZjK8QfS6VPEiTDtvHNTj410090	intact-crc:96126ECF4641F55D|rigid:01Mv5n7HYQouzDY77tFli25iKoA	false	sufficient binding region:2-111	sufficient binding region:119-325	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C0D7-2	uniprotkb:Q9DBC7	intact:EBI-645612|ensembl:ENSMUSP00000032480	intact:EBI-645677|uniprotkb:Q3UKU7|uniprotkb:Q9JHR5|uniprotkb:Q9JHR6|ensembl:ENSMUSP00000056500|ensembl:ENSMUSP00000102288	psi-mi:q8c0d7-2(display_long)|uniprotkb:Ing4(gene name)|psi-mi:Ing4(display_short)|uniprotkb:p29ING4(gene name synonym)|uniprotkb:mINGh-M(isoform synonym)	psi-mi:kap0_mouse(display_long)|uniprotkb:Prkar1a(gene name)|psi-mi:Prkar1a(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654640	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645598(ing4_mouse)|ensembl:ENSMUSG00000030330(gene)|ensembl:ENSMUST00000032480(transcript)	refseq:NP_001300902.1|refseq:NP_001300903.1|refseq:NP_001300904.1|refseq:NP_001300905.1|refseq:NP_068680.1|refseq:XP_017169829.1|dip:DIP-32450N|ensembl:ENSMUSG00000020612(gene)|ensembl:ENSMUST00000049527(transcript)|ensembl:ENSMUST00000106677(transcript)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001772"(immunological synapse)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005813"(centrosome)|go:"GO:0005930"(axoneme)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0007143"(female meiotic nuclear division)|go:"GO:0007507"(heart development)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030552"(cAMP binding)|go:"GO:0031588"(nucleotide-activated protein kinase complex)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|reactome:R-MMU-983231|reactome:R-MMU-5610787|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045835"(negative regulation of meiotic nuclear division)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0046007"(negative regulation of activated T cell proliferation)|go:"GO:0060038"(cardiac muscle cell proliferation)|go:"GO:0097224"(sperm connecting piece)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR014710(RmlC-like jelly roll fold)|interpro:IPR018488|interpro:IPR018490|mint:Q9DBC7|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|go:"GO:0043949"(regulation of cAMP-mediated signaling)|reactome:R-MMU-442720	afcs:20225(primary-reference)|afcs:53140(secondary-ac)	isoform-comment:May be due to a competing donor splice site.	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:zv972KDJy09rLn9CTrSNKrK/zDs10090	rogid:0KqlQxZjK8QfS6VPEiTDtvHNTj410090	intact-crc:7ADFA3E6CD61F41C|rigid:GN9aUa5lehr8dtPkCzgeBfR583U	false	sufficient binding region:8-190	sufficient binding region:119-325	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P61979-1	uniprotkb:Q03526	intact:EBI-1453334|ensembl:ENSMUSP00000039269|uniprotkb:Q07244-1	intact:EBI-647969|ensembl:ENSMUSP00000104860	psi-mi:p61979-1(display_long)|uniprotkb:Hnrnpk(gene name)|psi-mi:Hnrnpk(display_short)|uniprotkb:Hnrpk(gene name synonym)	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659083	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021546(gene)|ensembl:ENSMUST00000043269(transcript)|intact:EBI-299907(isoform-parent)	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)	afcs:16254(primary-reference)|afcs:24767(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc10090	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	intact-crc:3E97240F93C94C13|rigid:nc147cgT/QCXzTjK2as9rQMlQHE	false	sufficient binding region:196-404	sufficient binding region:170-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91WK7	uniprotkb:Q03526	intact:EBI-647914|uniprotkb:Q3UPC5|uniprotkb:Q3UZL7|ensembl:ENSMUSP00000047042	intact:EBI-647969|ensembl:ENSMUSP00000104860	psi-mi:anr54_mouse(display_long)|uniprotkb:Ankrd54(gene name)|psi-mi:Ankrd54(display_short)|uniprotkb:Liar(gene name synonym)|uniprotkb:Lyn-interacting ankyrin repeat protein(gene name synonym)	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659094	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659098.1|ensembl:ENSMUSG00000033055(gene)|ensembl:ENSMUST00000040676(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030496"(midbody)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:1902531"(regulation of intracellular signal transduction)|interpro:IPR002110(Ankyrin)|interpro:IPR036770	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)	afcs:16254(primary-reference)|afcs:16254(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c9kYWjbA+UFKS8Lhu0WO9c10iUk10090	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	intact-crc:C275123EB85CA211|rigid:LQG7xNjhae9I4CSmQHD0uxA9GGY	false	sufficient binding region:?-?	sufficient binding region:170-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91WK7	uniprotkb:Q03526	intact:EBI-647914|uniprotkb:Q3UPC5|uniprotkb:Q3UZL7|ensembl:ENSMUSP00000047042	intact:EBI-647969|ensembl:ENSMUSP00000104860	psi-mi:anr54_mouse(display_long)|uniprotkb:Ankrd54(gene name)|psi-mi:Ankrd54(display_short)|uniprotkb:Liar(gene name synonym)|uniprotkb:Lyn-interacting ankyrin repeat protein(gene name synonym)	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659104	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659098.1|ensembl:ENSMUSG00000033055(gene)|ensembl:ENSMUST00000040676(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030496"(midbody)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:1902531"(regulation of intracellular signal transduction)|interpro:IPR002110(Ankyrin)|interpro:IPR036770	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)	afcs:16254(primary-reference)|afcs:16254(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c9kYWjbA+UFKS8Lhu0WO9c10iUk10090	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	intact-crc:66C76871809CBEF9|rigid:LQG7xNjhae9I4CSmQHD0uxA9GGY	false	sufficient binding region:66-239	sufficient binding region:170-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TSI1	uniprotkb:Q03526	intact:EBI-647984|uniprotkb:Q3U3L2|uniprotkb:Q8CHU5|ensembl:ENSMUSP00000047327	intact:EBI-647969|ensembl:ENSMUSP00000104860	psi-mi:pkhm1_mouse(display_long)|uniprotkb:Plekhm1(gene name)|psi-mi:Plekhm1(display_short)	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659114	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_898855.1|ensembl:ENSMUSG00000034247(gene)|ensembl:ENSMUST00000041272(transcript)|go:"GO:0005730"(nucleolus)|go:"GO:0005764"(lysosome)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0015031"(protein transport)|go:"GO:0031902"(late endosome membrane)|go:"GO:0032418"(lysosome localization)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044754"(autolysosome)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046872"(metal ion binding)|go:"GO:0061909"(autophagosome-lysosome fusion)|go:"GO:1900029"(positive regulation of ruffle assembly)|go:"GO:1902774"(late endosome to lysosome transport)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR002219(Protein kinase C, phorbol ester/diacylglycerol binding)|interpro:IPR004012(RUN)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR025258|interpro:IPR037213|interpro:IPR042827	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)	afcs:16254(primary-reference)|afcs:91697(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Yjd7f9xDR0MLR5CADvnxqcO81Jk10090	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	intact-crc:145AB4676D0FEBD2|rigid:5i5rrVUXV5zsO745oXtFhlypbTg	false	sufficient binding region:449-660	sufficient binding region:170-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08791-2	uniprotkb:Q03526	intact:EBI-648010|ensembl:ENSMUSP00000033378	intact:EBI-647969|ensembl:ENSMUSP00000104860	psi-mi:o08791-2(display_long)|uniprotkb:0S(isoform synonym)|uniprotkb:Ebf3(gene name)|psi-mi:Ebf3(display_short)|uniprotkb:Coe3(gene name synonym)|uniprotkb:Early B-cell factor 3(gene name synonym)|uniprotkb:Olf-1/EBF-like 2(gene name synonym)	psi-mi:itk_mouse(display_long)|uniprotkb:T-cell-specific kinase(gene name synonym)|uniprotkb:IL-2-inducible T-cell kinase(gene name synonym)|uniprotkb:Kinase EMT(gene name synonym)|uniprotkb:Kinase TLK(gene name synonym)|uniprotkb:Itk(gene name)|psi-mi:Itk(display_short)|uniprotkb:Emt(gene name synonym)|uniprotkb:Tlk(gene name synonym)|uniprotkb:Tsk(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659124	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-647994(coe3_mouse)|ensembl:ENSMUSG00000010476(gene)|ensembl:ENSMUST00000033378(transcript)	refseq:NP_034713.2|refseq:NP_001268894.1|refseq:NP_001268895.1|refseq:NP_001268897.1|dip:DIP-29283N|ensembl:ENSMUSG00000020395(gene)|ensembl:ENSMUST00000109237(transcript)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0001865"(NK T cell differentiation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007202"(activation of phospholipase C activity)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038083"(peptidyl-tyrosine autophosphorylation)|go:"GO:0046629"(gamma-delta T cell activation)|go:"GO:0046872"(metal ion binding)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR001562(Tec/Btk)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR020635|interpro:IPR035583|interpro:IPR036028|interpro:IPR036860|interpro:IPR042785|mint:Q03526|rcsb pdb:1AWJ|rcsb pdb:1LUI|rcsb pdb:1LUK|rcsb pdb:1LUM|rcsb pdb:1LUN|rcsb pdb:2ETZ|rcsb pdb:2EU0|rcsb pdb:2K79|rcsb pdb:2K7A|rcsb pdb:2RN8|rcsb pdb:2RNA|rcsb pdb:3S9K|reactome:R-MMU-202433|reactome:R-MMU-2871809|go:"GO:0004713"(protein tyrosine kinase activity)	afcs:16254(primary-reference)|afcs:15951(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fY4CtQiyiUCPzo/m4gFSlOq81s410090	rogid:dcWqyqFSAMw1j5Ifa96f85GrdTA10090	intact-crc:3823A693C1BFD456|rigid:HZqfVJ6r+uNhENKeMvDLDuxkDxk	false	sufficient binding region:205-268	sufficient binding region:170-351	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54824	uniprotkb:Q7TS72	intact:EBI-641708|uniprotkb:O70236|uniprotkb:Q3TEM4|uniprotkb:Q8R0G5|uniprotkb:Q5DTR5|uniprotkb:Q9QZP6|ensembl:ENSMUSP00000001792	intact:EBI-648015|uniprotkb:Q3U384|ensembl:ENSMUSP00000003850	psi-mi:il16_mouse(display_long)|uniprotkb:Il16(gene name)|psi-mi:Il16(display_short)	psi-mi:ip3kc_mouse(display_long)|uniprotkb:Inositol 1,4,5-trisphosphate 3-kinase C(gene name synonym)|uniprotkb:Itpkc(gene name)|psi-mi:Itpkc(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659134	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034681.2|refseq:XP_006507449.1|refseq:XP_011239983.1|ensembl:ENSMUSG00000001741(gene)|ensembl:ENSMUST00000001792(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:1902565"(positive regulation of neutrophil activation)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR020450|interpro:IPR036034|mint:O54824|reactome:R-MMU-449836|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090543"(Flemming body)	refseq:NP_853624.1|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|interpro:IPR005522(Inositol polyphosphate kinase)|interpro:IPR038286|reactome:R-MMU-1855204|ensembl:ENSMUSG00000003752(gene)|ensembl:ENSMUST00000003850(transcript)|go:"GO:0000828"(inositol hexakisphosphate kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)	afcs:58014(primary-reference)|afcs:16232(secondary-ac)	-	-	caution:The prey construct contains 41 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:i4rzjOOqd/moda02EJD7CC5j+5Q10090	rogid:3mbDKQ5z4FUk/g2u5OPguk1U8eA10090	intact-crc:D7E84DEAC676FFE1|rigid:tRXFfwnyvKjyyId+uVecBfk56bE	false	sufficient binding region:699-1160	sufficient binding region:580-678	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54824	uniprotkb:Q7TS72	intact:EBI-641708|uniprotkb:O70236|uniprotkb:Q3TEM4|uniprotkb:Q8R0G5|uniprotkb:Q5DTR5|uniprotkb:Q9QZP6|ensembl:ENSMUSP00000001792	intact:EBI-648015|uniprotkb:Q3U384|ensembl:ENSMUSP00000003850	psi-mi:il16_mouse(display_long)|uniprotkb:Il16(gene name)|psi-mi:Il16(display_short)	psi-mi:ip3kc_mouse(display_long)|uniprotkb:Inositol 1,4,5-trisphosphate 3-kinase C(gene name synonym)|uniprotkb:Itpkc(gene name)|psi-mi:Itpkc(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659145	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034681.2|refseq:XP_006507449.1|refseq:XP_011239983.1|ensembl:ENSMUSG00000001741(gene)|ensembl:ENSMUST00000001792(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:1902565"(positive regulation of neutrophil activation)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR020450|interpro:IPR036034|mint:O54824|reactome:R-MMU-449836|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090543"(Flemming body)	refseq:NP_853624.1|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|interpro:IPR005522(Inositol polyphosphate kinase)|interpro:IPR038286|reactome:R-MMU-1855204|ensembl:ENSMUSG00000003752(gene)|ensembl:ENSMUST00000003850(transcript)|go:"GO:0000828"(inositol hexakisphosphate kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)	afcs:58014(primary-reference)|afcs:16232(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:i4rzjOOqd/moda02EJD7CC5j+5Q10090	rogid:3mbDKQ5z4FUk/g2u5OPguk1U8eA10090	intact-crc:8AD10C079EB90969|rigid:tRXFfwnyvKjyyId+uVecBfk56bE	false	sufficient binding region:782-1143	sufficient binding region:580-678	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54824	uniprotkb:Q7TS72	intact:EBI-641708|uniprotkb:O70236|uniprotkb:Q3TEM4|uniprotkb:Q8R0G5|uniprotkb:Q5DTR5|uniprotkb:Q9QZP6|ensembl:ENSMUSP00000001792	intact:EBI-648015|uniprotkb:Q3U384|ensembl:ENSMUSP00000003850	psi-mi:il16_mouse(display_long)|uniprotkb:Il16(gene name)|psi-mi:Il16(display_short)	psi-mi:ip3kc_mouse(display_long)|uniprotkb:Inositol 1,4,5-trisphosphate 3-kinase C(gene name synonym)|uniprotkb:Itpkc(gene name)|psi-mi:Itpkc(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659155	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034681.2|refseq:XP_006507449.1|refseq:XP_011239983.1|ensembl:ENSMUSG00000001741(gene)|ensembl:ENSMUST00000001792(transcript)|go:"GO:0005125"(cytokine activity)|go:"GO:0005615"(extracellular space)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0016607"(nuclear speck)|go:"GO:1902565"(positive regulation of neutrophil activation)|interpro:IPR001478(PDZ/DHR/GLGF)|interpro:IPR020450|interpro:IPR036034|mint:O54824|reactome:R-MMU-449836|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0030595"(leukocyte chemotaxis)|go:"GO:0032722"(positive regulation of chemokine production)|go:"GO:0032730"(positive regulation of interleukin-1 alpha production)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0042609"(CD4 receptor binding)|go:"GO:0050729"(positive regulation of inflammatory response)|go:"GO:0050930"(induction of positive chemotaxis)|go:"GO:0051924"(regulation of calcium ion transport)|go:"GO:0062023"(collagen-containing extracellular matrix)|go:"GO:0090543"(Flemming body)	refseq:NP_853624.1|go:"GO:0032958"(inositol phosphate biosynthetic process)|go:"GO:0046854"(phosphatidylinositol phosphate biosynthetic process)|interpro:IPR005522(Inositol polyphosphate kinase)|interpro:IPR038286|reactome:R-MMU-1855204|ensembl:ENSMUSG00000003752(gene)|ensembl:ENSMUST00000003850(transcript)|go:"GO:0000828"(inositol hexakisphosphate kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0008440"(inositol-1,4,5-trisphosphate 3-kinase activity)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)	afcs:58014(primary-reference)|afcs:16232(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:i4rzjOOqd/moda02EJD7CC5j+5Q10090	rogid:3mbDKQ5z4FUk/g2u5OPguk1U8eA10090	intact-crc:19BD6F5AF4412597|rigid:tRXFfwnyvKjyyId+uVecBfk56bE	false	sufficient binding region:892-1161	sufficient binding region:580-678	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9CZ62	uniprotkb:P62204	intact:EBI-648025|uniprotkb:Q8BL35|ensembl:ENSMUSP00000023270	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:cep97_mouse(display_long)|uniprotkb:Lrriq2(gene name synonym)|uniprotkb:Leucine-rich repeat and IQ domain-containing protein 2(gene name synonym)|uniprotkb:Cep97(gene name)|psi-mi:Cep97(display_short)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659165	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001152836.1|refseq:NP_001152837.1|refseq:NP_001152838.1|refseq:NP_083091.1|ensembl:ENSMUSG00000022604(gene)|ensembl:ENSMUST00000023270(transcript)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0030030"(cell projection organization)|go:"GO:0032991"(protein-containing complex)|go:"GO:0034451"(centriolar satellite)|go:"GO:1901673"(regulation of mitotic spindle assembly)|go:"GO:1902018"(negative regulation of cilium assembly)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR001611(Leucine-rich repeat)|interpro:IPR032675|mint:Q9CZ62|reactome:R-MMU-5620912|reactome:R-MMU-9013424	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	afcs:15753(primary-reference)|afcs:91693(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:DWiMTuw3lDIkq7+vwiCf3HJZZ7k10090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:92CE086967222165|rigid:PljMiTMWNdyrbLP/Nn05Yqt1f3A	false	sufficient binding region:415-657	sufficient binding region:1-149	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TSH4	uniprotkb:P62204	intact:EBI-646843|uniprotkb:Q6A072|ensembl:ENSMUSP00000038881|ensembl:ENSMUSP00000102167	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:cp110_mouse(display_long)|uniprotkb:Cep110(gene name synonym)|uniprotkb:Ccp110(gene name)|psi-mi:Ccp110(display_short)|uniprotkb:Kiaa0419(gene name synonym)|uniprotkb:Cp110(gene name synonym)|uniprotkb:Centrosomal protein of 110 kDa(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659176	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_892040.1|ensembl:ENSMUSG00000033904(gene)|ensembl:ENSMUST00000038650(transcript)|ensembl:ENSMUST00000106557(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005929"(cilium)|go:"GO:0007099"(centriole replication)|go:"GO:0032053"(ciliary basal body organization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1903723"(negative regulation of centriole elongation)|interpro:IPR033207|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5689880|reactome:R-MMU-8854518|reactome:R-MMU-9013424	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	afcs:15753(primary-reference)|afcs:55737(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Ma+OC215nDGgK9D4XMR9h7X4EV410090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:E2C463DBBF201256|rigid:p4aGVMaog91Kx0HeEQYhzwSKbsI	false	sufficient binding region:217-1004	sufficient binding region:1-149	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TSH4	uniprotkb:P62204	intact:EBI-646843|uniprotkb:Q6A072|ensembl:ENSMUSP00000038881|ensembl:ENSMUSP00000102167	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:cp110_mouse(display_long)|uniprotkb:Cep110(gene name synonym)|uniprotkb:Ccp110(gene name)|psi-mi:Ccp110(display_short)|uniprotkb:Kiaa0419(gene name synonym)|uniprotkb:Cp110(gene name synonym)|uniprotkb:Centrosomal protein of 110 kDa(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659186	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_892040.1|ensembl:ENSMUSG00000033904(gene)|ensembl:ENSMUST00000038650(transcript)|ensembl:ENSMUST00000106557(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005929"(cilium)|go:"GO:0007099"(centriole replication)|go:"GO:0032053"(ciliary basal body organization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1903723"(negative regulation of centriole elongation)|interpro:IPR033207|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5689880|reactome:R-MMU-8854518|reactome:R-MMU-9013424	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	afcs:15753(primary-reference)|afcs:55737(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Ma+OC215nDGgK9D4XMR9h7X4EV410090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:3D1791774DECCFF7|rigid:p4aGVMaog91Kx0HeEQYhzwSKbsI	false	sufficient binding region:444-959	sufficient binding region:1-149	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TSH4	uniprotkb:P62204	intact:EBI-646843|uniprotkb:Q6A072|ensembl:ENSMUSP00000038881|ensembl:ENSMUSP00000102167	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:cp110_mouse(display_long)|uniprotkb:Cep110(gene name synonym)|uniprotkb:Ccp110(gene name)|psi-mi:Ccp110(display_short)|uniprotkb:Kiaa0419(gene name synonym)|uniprotkb:Cp110(gene name synonym)|uniprotkb:Centrosomal protein of 110 kDa(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659196	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_892040.1|ensembl:ENSMUSG00000033904(gene)|ensembl:ENSMUST00000038650(transcript)|ensembl:ENSMUST00000106557(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005929"(cilium)|go:"GO:0007099"(centriole replication)|go:"GO:0032053"(ciliary basal body organization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1903723"(negative regulation of centriole elongation)|interpro:IPR033207|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5689880|reactome:R-MMU-8854518|reactome:R-MMU-9013424	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	afcs:15753(primary-reference)|afcs:55737(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Ma+OC215nDGgK9D4XMR9h7X4EV410090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:DA1427013BCF4C20|rigid:p4aGVMaog91Kx0HeEQYhzwSKbsI	false	sufficient binding region:589-887	sufficient binding region:1-149	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TSH4	uniprotkb:P62204	intact:EBI-646843|uniprotkb:Q6A072|ensembl:ENSMUSP00000038881|ensembl:ENSMUSP00000102167	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:cp110_mouse(display_long)|uniprotkb:Cep110(gene name synonym)|uniprotkb:Ccp110(gene name)|psi-mi:Ccp110(display_short)|uniprotkb:Kiaa0419(gene name synonym)|uniprotkb:Cp110(gene name synonym)|uniprotkb:Centrosomal protein of 110 kDa(gene name synonym)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659206	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_892040.1|ensembl:ENSMUSG00000033904(gene)|ensembl:ENSMUST00000038650(transcript)|ensembl:ENSMUST00000106557(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005929"(cilium)|go:"GO:0007099"(centriole replication)|go:"GO:0032053"(ciliary basal body organization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1903723"(negative regulation of centriole elongation)|interpro:IPR033207|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5689880|reactome:R-MMU-8854518|reactome:R-MMU-9013424	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	afcs:15753(primary-reference)|afcs:55737(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Ma+OC215nDGgK9D4XMR9h7X4EV410090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:FEB86341E66961D5|rigid:p4aGVMaog91Kx0HeEQYhzwSKbsI	false	sufficient binding region:623-998	sufficient binding region:1-149	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P97496-1	uniprotkb:P35235	intact:EBI-648064|ensembl:ENSMUSP00000086094	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:p97496-1(display_long)|uniprotkb:Smarcc1(gene name)|psi-mi:Smarcc1(display_short)|uniprotkb:Baf155(gene name synonym)|uniprotkb:Srg3(gene name synonym)|uniprotkb:BRG1-associated factor 155(gene name synonym)|uniprotkb:SWI/SNF complex 155 kDa subunit(gene name synonym)|uniprotkb:SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily C member 1(gene name synonym)|uniprotkb:SWI3-related protein(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659216	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-648047(smrc1_mouse)|ensembl:ENSMUSG00000032481(gene)|ensembl:ENSMUST00000088716(transcript)	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N	afcs:7464(primary-reference)|afcs:15304(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2020/01/07	rogid:yhuZC6SRcw/jSKI2+nruFD+QqlE10090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:AB5676AD6E736E43|rigid:CHEyH9EsA6nM5xt+cOvxwPUViFM	false	sufficient binding region:403-775	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6P1G0	uniprotkb:P35235	intact:EBI-648075|uniprotkb:Q3UUN8|uniprotkb:Q99KZ5|uniprotkb:Q9CSQ4|ensembl:ENSMUSP00000001002	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:heat6_mouse(display_long)|uniprotkb:Heatr6(gene name)|psi-mi:Heatr6(display_short)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659227	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_663407.2|ensembl:ENSMUSG00000000976(gene)|ensembl:ENSMUST00000001002(transcript)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR025283	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N	afcs:7464(primary-reference)|afcs:91701(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2020/01/07	rogid:MeIoA+j0crXcWqA2cYGHa7FcQhg10090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:6252BE24164EB2DC|rigid:wHMFkCgPwc+/GylsHlqC1G5yZXw	false	sufficient binding region:20-320	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q5SUF2	uniprotkb:P35235	intact:EBI-643396|uniprotkb:Q3U9D5|uniprotkb:Q8BUJ5|uniprotkb:Q921Z3|uniprotkb:Q9CRS7|uniprotkb:Q9CTY4|ensembl:ENSMUSP00000103450|ensembl:ENSMUSP00000103451	intact:EBI-397236|uniprotkb:Q3TQ84|uniprotkb:Q64509|uniprotkb:Q6PCL5|ensembl:ENSMUSP00000098333	psi-mi:lc7l3_mouse(display_long)|uniprotkb:Luc7l3(gene name)|psi-mi:Luc7l3(display_short)|uniprotkb:Crop(gene name synonym)|uniprotkb:Cisplatin resistance-associated-overexpressed protein(gene name synonym)	psi-mi:ptn11_mouse(display_long)|uniprotkb:Ptpn11(gene name)|psi-mi:Ptpn11(display_short)|uniprotkb:Protein-tyrosine phosphatase SYP(gene name synonym)|uniprotkb:SH-PTP2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659237	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080589.1|refseq:XP_006534073.1|refseq:XP_006534074.1|ensembl:ENSMUSG00000020863(gene)|ensembl:ENSMUST00000107820(transcript)|ensembl:ENSMUST00000107821(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0008380"(RNA splicing)|go:"GO:0016607"(nuclear speck)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)	refseq:NP_001103462.1|refseq:NP_035332.1|go:"GO:0048609"(multicellular organismal reproductive process)|go:"GO:0048659"(smooth muscle cell proliferation)|go:"GO:0048806"(genitalia development)|go:"GO:0048839"(inner ear development)|go:"GO:0048873"(homeostasis of number of cells within a tissue)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0051428"(peptide hormone receptor binding)|go:"GO:0051463"(negative regulation of cortisol secretion)|go:"GO:0051894"(positive regulation of focal adhesion assembly)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060125"(negative regulation of growth hormone secretion)|go:"GO:0060325"(face morphogenesis)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0061582"(intestinal epithelial cell migration)|go:"GO:0070301"(cellular response to hydrogen peroxide)|go:"GO:0070374"(positive regulation of ERK1 and ERK2 cascade)|interpro:IPR012152(Protein-tyrosine phosphatase, non-receptor type-6, -11)|interpro:IPR016130(Protein-tyrosine phosphatase, active site)|interpro:IPR029021|interpro:IPR036860|mint:P35235|rcsb pdb:1AYA|rcsb pdb:1AYB|rcsb pdb:1AYC|rcsb pdb:1AYD|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|reactome:R-MMU-1059683|reactome:R-MMU-109704|go:"GO:1904385"(cellular response to angiotensin)|go:"GO:1990314"(cellular response to insulin-like growth factor stimulus)|reactome:R-MMU-110056|go:"GO:1990782"(protein tyrosine kinase binding)|interpro:IPR000242(Protein-tyrosine phosphatase, receptor/non-receptor type)|reactome:R-MMU-112411|reactome:R-MMU-114604|interpro:IPR000387(Protein-tyrosine phosphatase)|interpro:IPR000980(SH2 motif)|reactome:R-MMU-1257604|interpro:IPR003595(Protein-tyrosine phosphatase, catalytic)|reactome:R-MMU-1295596|reactome:R-MMU-1433557|reactome:R-MMU-180292|reactome:R-MMU-186763|reactome:R-MMU-210990|reactome:R-MMU-210993|reactome:R-MMU-388841|reactome:R-MMU-389513|reactome:R-MMU-389948|reactome:R-MMU-432142|reactome:R-MMU-512988|reactome:R-MMU-5654689|reactome:R-MMU-8854691|reactome:R-MMU-8865999|reactome:R-MMU-8934593|reactome:R-MMU-909733|reactome:R-MMU-912694|reactome:R-MMU-936964|reactome:R-MMU-9674555|reactome:R-MMU-5654693|reactome:R-MMU-5654695|reactome:R-MMU-5654700|reactome:R-MMU-5654706|reactome:R-MMU-5654710|reactome:R-MMU-5654712|reactome:R-MMU-5654720|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-6811558|reactome:R-MMU-8853659|ensembl:ENSMUSG00000043733(gene)|ensembl:ENSMUST00000100770(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004721"(phosphoprotein phosphatase activity)|go:"GO:0004725"(protein tyrosine phosphatase activity)|go:"GO:0004726"(non-membrane spanning protein tyrosine phosphatase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006629"(lipid metabolic process)|go:"GO:0006641"(triglyceride metabolic process)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0007409"(axonogenesis)|go:"GO:0007420"(brain development)|go:"GO:0007507"(heart development)|go:"GO:0008543"(fibroblast growth factor receptor signaling pathway)|go:"GO:0009755"(hormone-mediated signaling pathway)|go:"GO:0009967"(positive regulation of signal transduction)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0021697"(cerebellar cortex formation)|go:"GO:0030159"(signaling receptor complex adaptor activity)|go:"GO:0030220"(platelet formation)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031748"(D1 dopamine receptor binding)|go:"GO:0032331"(negative regulation of chondrocyte differentiation)|go:"GO:0032528"(microvillus organization)|go:"GO:0032728"(positive regulation of interferon-beta production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0006470"(protein dephosphorylation)|go:"GO:0033277"(abortive mitotic cell cycle)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0033629"(negative regulation of cell adhesion mediated by integrin)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0035265"(organ growth)|go:"GO:0035335"(peptidyl-tyrosine dephosphorylation)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0036302"(atrioventricular canal development)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042445"(hormone metabolic process)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043408"(regulation of MAPK cascade)|go:"GO:0043560"(insulin receptor substrate binding)|go:"GO:0044853"(plasma membrane raft)|go:"GO:0045296"(cadherin binding)|go:"GO:0045778"(positive regulation of ossification)|go:"GO:0045931"(positive regulation of mitotic cell cycle)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046628"(positive regulation of insulin receptor signaling pathway)|go:"GO:0046676"(negative regulation of insulin secretion)|go:"GO:0046825"(regulation of protein export from nucleus)|go:"GO:0046887"(positive regulation of hormone secretion)|go:"GO:0046888"(negative regulation of hormone secretion)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|dip:DIP-29669N	afcs:7464(primary-reference)|afcs:34957(secondary-ac)	-	-	caution:The prey construct contains 6 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2020/01/07	rogid:pb8JxU2FNO7WcXwgcRr4kx9hVbI10090	rogid:KL26Wt9vwG525fZ5SfvLc71Wsng10090	intact-crc:E723641C65ECF6F2|rigid:CJB13Ai66/wKBjFe/kYZsCXqZ6g	false	sufficient binding region:1-153	sufficient binding region:?-?	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ERK4	uniprotkb:G5E829	intact:EBI-400836|intact:EBI-4283823|ensembl:ENSMUSP00000002790	intact:EBI-687987|ensembl:ENSMUSP00000020107	psi-mi:xpo2_mouse(display_long)|uniprotkb:Cse1l(gene name)|psi-mi:Cse1l(display_short)|uniprotkb:Importin-alpha re-exporter(gene name synonym)|uniprotkb:Chromosome segregation 1-like protein(gene name synonym)|uniprotkb:Xpo2(gene name synonym)	psi-mi:at2b1_mouse(display_long)|uniprotkb:Atp2b1(gene name)|psi-mi:Atp2b1(display_short)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688581	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_076054.1|ensembl:ENSMUSG00000002718(gene)|ensembl:ENSMUST00000002790(transcript)|go:"GO:0005049"(nuclear export signal receptor activity)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006611"(protein export from nucleus)|go:"GO:0031267"(small GTPase binding)|interpro:IPR001494(Importin-beta, N-terminal)|interpro:IPR005043(CAS/CSE, C-terminal)|interpro:IPR011989(Armadillo-like helical)|interpro:IPR013713(Exportin, Cse1-like)|interpro:IPR016024(Armadillo-type fold)|mint:Q9ERK4	refseq:NP_080758.1|refseq:XP_011241851.1|ensembl:ENSMUSG00000019943(gene)|ensembl:ENSMUST00000020107(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1901660"(calcium ion export)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|reactome:R-MMU-418359|reactome:R-MMU-5578775|reactome:R-MMU-936837	afcs:53735(primary-reference)|afcs:24596(secondary-ac)	-	comment:ATPase, Ca++ transporting, plasma membrane 1|comment:"AfCS Y2H protein 53735. Sequence retrieved from cross-reference Protein GI: 28500402"|comment:"similar to AT2B1_PIG Plasma membrane calcium-transporting ATPase 1 (99%)."|caution:"[gi:28500402] This record was removed as a result of standard genome annotation processing."	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:vJpTu+2YjwIRrjM3V815K3lZzAg10090	rogid:xCo2VYA4dyZrc2qUJTS9IbA4TIQ10090	intact-crc:79759B38C2194986|rigid:xv+FGNV3lSQ0KAIgqioz3hXvyNM	false	sufficient binding region:8-262	sufficient binding region:1-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:G5E829	intact:EBI-687548	intact:EBI-687987|ensembl:ENSMUSP00000020107	-	psi-mi:at2b1_mouse(display_long)|uniprotkb:Atp2b1(gene name)|psi-mi:Atp2b1(display_short)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym)	psi-mi:sec31l1_mouse_protei(display_short)|psi-mi:EBI-687548(display_long)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688594	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080758.1|refseq:XP_011241851.1|ensembl:ENSMUSG00000019943(gene)|ensembl:ENSMUST00000020107(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1901660"(calcium ion export)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|reactome:R-MMU-418359|reactome:R-MMU-5578775|reactome:R-MMU-936837	afcs:40270(primary-reference)	afcs:53735(primary-reference)|afcs:40270(secondary-ac)	comment:ATPase, Ca++ transporting, plasma membrane 1|comment:"AfCS Y2H protein 53735. Sequence retrieved from cross-reference Protein GI: 28500402"|comment:"similar to AT2B1_PIG Plasma membrane calcium-transporting ATPase 1 (99%)."|caution:"[gi:28500402] This record was removed as a result of standard genome annotation processing."	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:AfCS Y2H protein. Translated from nucleotide sequence.|comment:"similar to human SEC31L1 protein (90%)."	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:xCo2VYA4dyZrc2qUJTS9IbA4TIQ10090	rogid:KKcbi6CaFBl5ed3b0Y9sNstcTp010090	intact-crc:068FB7108013C7D2|rigid:hXmIHeP1VnGapCZ/qCOp3xXhYTk	false	sufficient binding region:1-110	sufficient binding region:168-521	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99LQ1	uniprotkb:G5E829	intact:EBI-688604|uniprotkb:Q3TBM3|ensembl:ENSMUSP00000021416	intact:EBI-687987|ensembl:ENSMUSP00000020107	psi-mi:mbip1_mouse(display_long)|uniprotkb:MAPK upstream kinase-binding inhibitory protein(gene name synonym)|uniprotkb:Mbip(gene name)|psi-mi:Mbip(display_short)	psi-mi:at2b1_mouse(display_long)|uniprotkb:Atp2b1(gene name)|psi-mi:Atp2b1(display_short)|uniprotkb:Plasma membrane calcium ATPase isoform 1(gene name synonym)|uniprotkb:Plasma membrane calcium pump isoform 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688610	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_663417.1|ensembl:ENSMUSG00000021028(gene)|ensembl:ENSMUST00000021416(transcript)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005671"(obsolete Ada2/Gcn5/Ada3 transcription activator complex)|go:"GO:0005730"(nucleolus)|go:"GO:0005829"(cytosol)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0042802"(identical protein binding)|go:"GO:0043966"(histone H3 acetylation)|go:"GO:0046330"(positive regulation of JNK cascade)|interpro:IPR026062|mint:Q99LQ1	refseq:NP_080758.1|refseq:XP_011241851.1|ensembl:ENSMUSG00000019943(gene)|ensembl:ENSMUST00000020107(transcript)|go:"GO:0001772"(immunological synapse)|go:"GO:0001818"(negative regulation of cytokine production)|go:"GO:0003056"(regulation of vascular associated smooth muscle contraction)|go:"GO:0003407"(neural retina development)|go:"GO:0005388"(P-type calcium transporter activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005887"(integral component of plasma membrane)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006874"(cellular calcium ion homeostasis)|go:"GO:0007420"(brain development)|go:"GO:0007568"(aging)|go:"GO:0008217"(regulation of blood pressure)|go:"GO:0009409"(response to cold)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0015085"(calcium ion transmembrane transporter activity)|go:"GO:0016323"(basolateral plasma membrane)|go:"GO:0016324"(apical plasma membrane)|go:"GO:0019829"(ATPase-coupled cation transmembrane transporter activity)|go:"GO:0030165"(PDZ domain binding)|go:"GO:0030285"(integral component of synaptic vesicle membrane)|go:"GO:0030501"(positive regulation of bone mineralization)|go:"GO:0032590"(dendrite membrane)|go:"GO:0032591"(dendritic spine membrane)|go:"GO:0032809"(neuronal cell body membrane)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045177"(apical part of cell)|go:"GO:0046872"(metal ion binding)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0051481"(negative regulation of cytosolic calcium ion concentration)|go:"GO:0051928"(positive regulation of calcium ion transport)|go:"GO:0071305"(cellular response to vitamin D)|go:"GO:0071386"(cellular response to corticosterone stimulus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0098982"(GABA-ergic synapse)|go:"GO:0099056"(integral component of presynaptic membrane)|go:"GO:0099059"(integral component of presynaptic active zone membrane)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|go:"GO:1900076"(regulation of cellular response to insulin stimulus)|go:"GO:1901660"(calcium ion export)|go:"GO:1905056"(P-type calcium transporter activity involved in regulation of presynaptic cytosolic calcium ion concentration)|go:"GO:1990034"(calcium ion export across plasma membrane)|interpro:IPR001757(ATPase, P-type, K/Mg/Cd/Cu/Zn/Na/Ca/Na/H-transporter)|interpro:IPR004014(ATPase, P-type cation-transporter, N-terminal)|interpro:IPR006068(ATPase, P-type cation-transporter, C-terminal)|interpro:IPR006408(Calcium-translocating P-type ATPase, PMCA-type)|interpro:IPR008250(E1-E2 ATPase-associated region)|interpro:IPR018303|interpro:IPR022141|interpro:IPR023214|interpro:IPR023298|interpro:IPR023299|interpro:IPR030320|interpro:IPR036412|interpro:IPR044492|reactome:R-MMU-418359|reactome:R-MMU-5578775|reactome:R-MMU-936837	afcs:53735(primary-reference)|afcs:91695(secondary-ac)	-	comment:ATPase, Ca++ transporting, plasma membrane 1|comment:"AfCS Y2H protein 53735. Sequence retrieved from cross-reference Protein GI: 28500402"|comment:"similar to AT2B1_PIG Plasma membrane calcium-transporting ATPase 1 (99%)."|caution:"[gi:28500402] This record was removed as a result of standard genome annotation processing."	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:KtWoLiw2udaTSOzc3EHifvyF45M10090	rogid:xCo2VYA4dyZrc2qUJTS9IbA4TIQ10090	intact-crc:CD6D0BAFE614B3DD|rigid:jF78h9x1l+jA94LRS4ms4MWrIcI	false	sufficient binding region:85-341	sufficient binding region:1-110	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CBI8	uniprotkb:P62204	intact:EBI-687996	intact:EBI-397460|uniprotkb:P02593|uniprotkb:P70667|uniprotkb:P99014|uniprotkb:Q3TEH7|uniprotkb:Q3THK5|uniprotkb:Q3U6Z5|uniprotkb:Q3U7C7|uniprotkb:Q498A3|uniprotkb:Q61379|uniprotkb:Q61380|uniprotkb:Q8BNC9|uniprotkb:Q91VQ9|uniprotkb:Q9D6G4|dip:DIP-31550N|uniprotkb:P0DP26|uniprotkb:P0DP28	psi-mi:q8cbi8_mouse(display_long)|uniprotkb:AI115600(gene name synonym)|uniprotkb:Dennd4a(gene name)|psi-mi:Dennd4a(display_short)	psi-mi:calm_mouse(display_long)|uniprotkb:Calm1(gene name)|psi-mi:Calm1(display_short)|uniprotkb:Calm(gene name synonym)|uniprotkb:Cam1(gene name synonym)|uniprotkb:Calm2(gene name)|psi-mi:Calm2(display_short)|uniprotkb:Cam2(gene name synonym)|uniprotkb:Camb(gene name synonym)|uniprotkb:Calm3(gene name)|psi-mi:Calm3(display_short)|uniprotkb:Cam3(gene name synonym)|uniprotkb:Camc(gene name synonym)|uniprotkb:Cam(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688620	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032483"(regulation of Rab protein signal transduction)	rcsb pdb:3WFN|rcsb pdb:4HEX|go:"GO:0005509"(calcium ion binding)|go:"GO:0000922"(spindle pole)|refseq:NP_031615.1|refseq:NP_031616.1|refseq:NP_033920.1|rcsb pdb:2IX7|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|interpro:IPR002048(Calcium-binding EF-hand)|rcsb pdb:2DFS|refseq:NP_001300863.1|go:"GO:0000086"(G2/M transition of mitotic cell cycle)|go:"GO:0008076"(voltage-gated potassium channel complex)|go:"GO:0043388"(positive regulation of DNA binding)|reactome:R-MMU-2672351|reactome:R-MMU-418359|reactome:R-MMU-425561|reactome:R-MMU-5578775|reactome:R-MMU-936837|go:"GO:0005829"(cytosol)|reactome:R-MMU-8876725|rcsb pdb:4E50|rcsb pdb:4E53|go:"GO:0061024"(membrane organization)|rcsb pdb:4ZLK|reactome:R-MMU-1445148|reactome:R-MMU-5576892|ensembl:ENSMUST00000019514|ensembl:ENSMUST00000040440|ensembl:ENSMUST00000110082|reactome:R-MMU-111932|reactome:R-MMU-111933|reactome:R-MMU-111957|reactome:R-MMU-114608|reactome:R-MMU-1474151|reactome:R-MMU-1855204|reactome:R-MMU-203615|reactome:R-MMU-2871809|reactome:R-MMU-4086398|reactome:R-MMU-442717|reactome:R-MMU-442729|reactome:R-MMU-442745|reactome:R-MMU-442982|reactome:R-MMU-445355|reactome:R-MMU-451308|reactome:R-MMU-5607763|reactome:R-MMU-5626467|reactome:R-MMU-5218920|reactome:R-MMU-5627123|reactome:R-MMU-5673001|reactome:R-MMU-70221|ensembl:ENSMUSG00000001175|ensembl:ENSMUSG00000019370|ensembl:ENSMUSG00000036438|ensembl:ENSMUSP00000019514|ensembl:ENSMUSP00000048857|ensembl:ENSMUSP00000105709|reactome:R-MMU-2514859|reactome:R-MMU-163615|go:"GO:0034704"(calcium channel complex)|go:"GO:0005813"(centrosome)|go:"GO:0070062"(extracellular exosome)|go:"GO:0030426"(growth cone)|go:"GO:0005634"(nucleus)|go:"GO:0030017"(sarcomere)|go:"GO:0005876"(spindle microtubule)|go:"GO:0030235"(nitric-oxide synthase regulator activity)|go:"GO:0072542"(protein phosphatase activator activity)|go:"GO:0007190"(activation of adenylate cyclase activity)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0005513"(detection of calcium ion)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051000"(positive regulation of nitric-oxide synthase activity)|go:"GO:0032516"(positive regulation of phosphoprotein phosphatase activity)|go:"GO:0060316"(positive regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0055117"(regulation of cardiac muscle contraction)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0002027"(regulation of heart rate)|go:"GO:1901841"(regulation of high voltage-gated calcium channel activity)|go:"GO:0010880"(regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0001975"(response to amphetamine)|go:"GO:0051412"(response to corticosterone)|go:"GO:0021762"(substantia nigra development)|rcsb pdb:1UP5|go:"GO:1902494"(catalytic complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0043209"(myelin sheath)|go:"GO:0014069"(postsynaptic density)|go:"GO:0043234"|go:"GO:0008179"(adenylate cyclase binding)|go:"GO:0019855"(calcium channel inhibitor activity)|go:"GO:0097718"(disordered domain specific binding)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0031432"(titin binding)|go:"GO:0060315"(negative regulation of ryanodine-sensitive calcium-release channel activity)|go:"GO:0030819"(obsolete positive regulation of cAMP biosynthetic process)|go:"GO:0060314"(regulation of ryanodine-sensitive calcium-release channel activity)|reactome:R-MMU-2025928|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0043005"(neuron projection)|go:"GO:0005886"(plasma membrane)|go:"GO:0030672"(synaptic vesicle membrane)|go:"GO:0010856"(adenylate cyclase activator activity)|go:"GO:0048306"(calcium-dependent protein binding)|go:"GO:0030234"(enzyme regulator activity)|go:"GO:0031997"(N-terminal myristoylation domain binding)|go:"GO:0050998"(nitric-oxide synthase binding)|go:"GO:0043548"(phosphatidylinositol 3-kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0031800"(type 3 metabotropic glutamate receptor binding)|go:"GO:0090151"(establishment of protein localization to mitochondrial membrane)|go:"GO:0075206"(obsolete positive regulation by host of symbiont cAMP-mediated signal transduction)|go:"GO:1900242"(regulation of synaptic vesicle endocytosis)|go:"GO:2000300"(regulation of synaptic vesicle exocytosis)|go:"GO:0051300"(spindle pole body organization)|interpro:IPR039030	afcs:91699(secondary-ac)|afcs:15753(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Bl/I6JvRemIIGojswh8vduSwNtk10090	rogid:tTYcOd9bOh211njZVz7cYVybAMQ10090	intact-crc:FBD9AB02D80813F4|rigid:DXZ9V+5N5dMBw7KfMgoQKi9d2f4	false	-	sufficient binding region:1-149	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08911	uniprotkb:P47811	intact:EBI-645214|uniprotkb:Q9D0M4|ensembl:ENSMUSP00000086207	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:mk12_mouse(display_long)|uniprotkb:Extracellular signal-regulated kinase 6(gene name synonym)|uniprotkb:Stress-activated protein kinase 3(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 gamma(gene name synonym)|uniprotkb:Mapk12(gene name)|psi-mi:Mapk12(display_short)|uniprotkb:Sapk3(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654029	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038899.1|ensembl:ENSMUSG00000022610(gene)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007049"(cell cycle)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045786"(negative regulation of cell cycle)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|go:"GO:0000287"(magnesium ion binding)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038786|reactome:R-MMU-168638|reactome:R-MMU-376172|reactome:R-MMU-4420097|reactome:R-MMU-525793|reactome:R-MMU-5675221|ensembl:ENSMUST00000088827(transcript)|dip:DIP-49622N	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:17512(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:mrjME9tgwfe4Bfu/d2D+JHstrLI10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:772EA5C6354D2BAF|rigid:pbIaqxCD4nPpeO4h5wLud9M2gd8	false	sufficient binding region:261-367	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9WTU6-2	uniprotkb:P47811	intact:EBI-432211|ensembl:ENSMUSP00000099839|ensembl:ENSMUSP00000104808	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:q9wtu6-2(display_long)|uniprotkb:Mapk9(gene name)|psi-mi:Mapk9(display_short)|uniprotkb:Jnk2(gene name synonym)|uniprotkb:Prkm9(gene name synonym)|uniprotkb:Stress-activated protein kinase JNK2(gene name synonym)|uniprotkb:c-Jun N-terminal kinase 2(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654039	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020366(gene)|ensembl:ENSMUST00000102778(transcript)|ensembl:ENSMUST00000109179(transcript)|intact:EBI-298798(mk09_mouse)	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:17841(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:UwEqrgBBGhS9sCyCbrt1RtYH8iI10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:E7B6D7D252DE7621|rigid:zQsiMynZhS+yxghUxkbxNZrEmTw	false	sufficient binding region:231-381	sufficient binding region:3-125	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q01768	uniprotkb:P47811	intact:EBI-642573|ensembl:ENSMUSP00000021217|ensembl:ENSMUSP00000103476	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:ndkb_mouse(display_long)|uniprotkb:nm23-M2(gene name synonym)|uniprotkb:P18(gene name synonym)|uniprotkb:Nme2(gene name)|psi-mi:Nme2(display_short)|uniprotkb:Histidine protein kinase NDKB(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654079	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001070997.1|refseq:NP_032731.1|ensembl:ENSMUSG00000020857(gene)|ensembl:ENSMUST00000021217(transcript)|ensembl:ENSMUST00000072566(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0004550"(nucleoside diphosphate kinase activity)|go:"GO:0004673"(protein histidine kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005504"(fatty acid binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005882"(intermediate filament)|go:"GO:0006165"(nucleoside diphosphate phosphorylation)|go:"GO:0006183"(GTP biosynthetic process)|go:"GO:0006228"(UTP biosynthetic process)|go:"GO:0006241"(CTP biosynthetic process)|go:"GO:0007189"(adenylate cyclase-activating G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0009142"(nucleoside triphosphate biosynthetic process)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0019003"(GDP binding)|go:"GO:0019215"(intermediate filament binding)|go:"GO:0019899"(enzyme binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0034599"(cellular response to oxidative stress)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043209"(myelin sheath)|go:"GO:0045618"(positive regulation of keratinocyte differentiation)|go:"GO:0045682"(regulation of epidermis development)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046872"(metal ion binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0051880"(G-quadruplex DNA binding)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071398"(cellular response to fatty acid)|go:"GO:0071944"(cell periphery)|go:"GO:1901363"(heterocyclic compound binding)|interpro:IPR001564(Nucleoside diphosphate kinase, core)|interpro:IPR023005|interpro:IPR034907|interpro:IPR036850|mint:Q01768|reactome:R-MMU-499943|reactome:R-MMU-6798695	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:7069(secondary-ac)	-	-	caution:The prey construct contains 18 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AJ1Depmyy9zwTEUOZMRO7TKPd1k10090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:3BB8AA6051A58B2A|rigid:hF+ISmhym7vfDk+9uxa1/7LrnOM	false	sufficient binding region:1-152	sufficient binding region:200-360	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BP92	uniprotkb:P47811	intact:EBI-642694|uniprotkb:O70341|uniprotkb:A2RT07|ensembl:ENSMUSP00000109915	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:rcn2_mouse(display_long)|uniprotkb:Taipoxin-associated calcium-binding protein 49(gene name synonym)|uniprotkb:Rcn2(gene name)|psi-mi:Rcn2(display_short)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654089	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036122.2|ensembl:ENSMUSG00000032320(gene)|ensembl:ENSMUST00000114276(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q8BP92|dip:DIP-46963N	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:17113(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:vsMMmWAPrlDNQDUxzH4wrp1Jub410090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:36F8D726933E911A|rigid:H/GM9ux8qSwVV4dkaTxjsTdtUrg	false	sufficient binding region:1-249	sufficient binding region:200-360	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BP92	uniprotkb:P47811	intact:EBI-642694|uniprotkb:O70341|uniprotkb:A2RT07|ensembl:ENSMUSP00000109915	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:rcn2_mouse(display_long)|uniprotkb:Taipoxin-associated calcium-binding protein 49(gene name synonym)|uniprotkb:Rcn2(gene name)|psi-mi:Rcn2(display_short)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654099	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036122.2|ensembl:ENSMUSG00000032320(gene)|ensembl:ENSMUST00000114276(transcript)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005730"(nucleolus)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005788"(endoplasmic reticulum lumen)|interpro:IPR002048(Calcium-binding EF-hand)|interpro:IPR011992(EF-Hand type)|interpro:IPR018247|mint:Q8BP92|dip:DIP-46963N	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:17113(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:vsMMmWAPrlDNQDUxzH4wrp1Jub410090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:B3EF6C67B82F519C|rigid:H/GM9ux8qSwVV4dkaTxjsTdtUrg	false	sufficient binding region:1-229	sufficient binding region:200-360	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JIF7	uniprotkb:P47811	intact:EBI-643655|uniprotkb:Q3T9Y4|uniprotkb:Q3TT72|uniprotkb:Q3U8G9|uniprotkb:Q3UE02|ensembl:ENSMUSP00000033012	intact:EBI-298727|ensembl:ENSMUSP00000061958|uniprotkb:O08666|uniprotkb:Q3U6R5|uniprotkb:Q3UZS3|uniprotkb:Q8C289|uniprotkb:Q9JLV8|uniprotkb:Q9QZ80|uniprotkb:B2KF37|uniprotkb:B2KF38	psi-mi:copb_mouse(display_long)|uniprotkb:Beta-coat protein(gene name synonym)|uniprotkb:Copb1(gene name)|psi-mi:Copb1(display_short)|uniprotkb:Copb(gene name synonym)	psi-mi:mk14_mouse(display_long)|uniprotkb:Mapk14(gene name)|psi-mi:Mapk14(display_short)|uniprotkb:Crk1(gene name synonym)|uniprotkb:Csbp1(gene name synonym)|uniprotkb:Csbp2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase p38 alpha(gene name synonym)|uniprotkb:CRK1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654119	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_203534.1|ensembl:ENSMUSG00000030754(gene)|ensembl:ENSMUST00000033012(transcript)|go:"GO:0000139"(Golgi membrane)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005793"(endoplasmic reticulum-Golgi intermediate compartment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005798"(Golgi-associated vesicle)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006888"(endoplasmic reticulum to Golgi vesicle-mediated transport)|go:"GO:0006891"(intra-Golgi vesicle-mediated transport)|go:"GO:0030126"(COPI vesicle coat)|go:"GO:0030137"(COPI-coated vesicle)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR011710(Coatomer, beta subunit, C-terminal)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR016460(Coatomer, beta subunit)|interpro:IPR029446|mint:Q9JIF7|rcsb pdb:5A1U|rcsb pdb:5A1V|rcsb pdb:5A1W|rcsb pdb:5A1X|rcsb pdb:5A1Y|rcsb pdb:5NZR|rcsb pdb:5NZS|rcsb pdb:5NZT|rcsb pdb:5NZU|rcsb pdb:5NZV|reactome:R-MMU-6798695|reactome:R-MMU-6807878|reactome:R-MMU-6811434|dip:DIP-42642N	reactome:R-MMU-4420097|reactome:R-MMU-450302|reactome:R-MMU-450341|reactome:R-MMU-525793|reactome:R-MMU-5668599|reactome:R-MMU-6798695|reactome:R-MMU-6804756|ensembl:ENSMUSG00000053436(gene)|ensembl:ENSMUST00000062694(transcript)|go:"GO:0000077"(DNA damage checkpoint signaling)|go:"GO:0000165"(MAPK cascade)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0000922"(spindle pole)|go:"GO:0001502"(cartilage condensation)|go:"GO:0001525"(angiogenesis)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001890"(placenta development)|go:"GO:0002062"(chondrocyte differentiation)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006006"(glucose metabolic process)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0007519"(skeletal muscle tissue development)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010831"(positive regulation of myotube differentiation)|go:"GO:0016301"(kinase activity)|go:"GO:0016607"(nuclear speck)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019395"(fatty acid oxidation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031281"(positive regulation of cyclase activity)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032495"(response to muramyl dipeptide)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0035331"(negative regulation of hippo signaling)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0035924"(cellular response to vascular endothelial growth factor stimulus)|go:"GO:0035994"(response to muscle stretch)|go:"GO:0038066"(p38MAPK cascade)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042770"(signal transduction in response to DNA damage)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045663"(positive regulation of myoblast differentiation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048273"(mitogen-activated protein kinase p38 binding)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051525"(NFAT protein binding)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060348"(bone development)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071223"(cellular response to lipoteichoic acid)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0071479"(cellular response to ionizing radiation)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0090336"(positive regulation of brown fat cell differentiation)|rcsb pdb:1LEZ|rcsb pdb:1YW2|rcsb pdb:1YWR|rcsb pdb:2EWA|rcsb pdb:2GHL|rcsb pdb:2GHM|rcsb pdb:2GTM|rcsb pdb:2GTN|go:"GO:0090400"(stress-induced premature senescence)|go:"GO:0098586"(cellular response to virus)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099179"(regulation of synaptic membrane adhesion)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1900015"(regulation of cytokine production involved in inflammatory response)|go:"GO:1901741"(positive regulation of myoblast fusion)|go:"GO:2000379"(positive regulation of reactive oxygen species metabolic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008352(MAP kinase, p38)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR038784|mint:P47811|rcsb pdb:1LEW|rcsb pdb:5R9F|rcsb pdb:5R9G|rcsb pdb:5R9H|rcsb pdb:5R9I|rcsb pdb:2OZA|rcsb pdb:2PUU|rcsb pdb:3P4K|rcsb pdb:3P5K|rcsb pdb:3P78|rcsb pdb:3P79|rcsb pdb:3P7A|rcsb pdb:3P7B|rcsb pdb:3P7C|rcsb pdb:3PY3|rcsb pdb:3TG1|rcsb pdb:4KA3|rcsb pdb:4LOO|rcsb pdb:4LOP|rcsb pdb:4LOQ|rcsb pdb:4TYH|rcsb pdb:5LAR|rcsb pdb:5NZZ|rcsb pdb:5O90|rcsb pdb:5R8U|rcsb pdb:5R8V|rcsb pdb:5R8W|rcsb pdb:5R8X|rcsb pdb:5R8Y|rcsb pdb:5R8Z|rcsb pdb:5R90|rcsb pdb:5R91|rcsb pdb:5R92|rcsb pdb:5R93|rcsb pdb:5R94|rcsb pdb:5R95|rcsb pdb:5R96|rcsb pdb:5R97|rcsb pdb:5R98|rcsb pdb:5R99|rcsb pdb:5R9A|rcsb pdb:5R9B|rcsb pdb:5R9C|rcsb pdb:5R9D|rcsb pdb:5R9E|rcsb pdb:5R9J|rcsb pdb:5R9K|rcsb pdb:5R9L|rcsb pdb:5R9M|rcsb pdb:5R9N|rcsb pdb:5R9O|rcsb pdb:5R9P|rcsb pdb:5R9Q|rcsb pdb:5R9R|rcsb pdb:5R9S|rcsb pdb:5R9T|rcsb pdb:5R9U|rcsb pdb:5R9V|rcsb pdb:5R9W|rcsb pdb:5R9X|rcsb pdb:5R9Y|rcsb pdb:5R9Z|rcsb pdb:5RA0|rcsb pdb:5RA1|rcsb pdb:5RA2|rcsb pdb:5RA3|rcsb pdb:5RA4|rcsb pdb:5RA5|rcsb pdb:5RA6|rcsb pdb:5RA7|rcsb pdb:5RA8|rcsb pdb:5RA9|rcsb pdb:5UOJ|rcsb pdb:6SO1|rcsb pdb:6SO2|rcsb pdb:6SO4|rcsb pdb:6SOD|rcsb pdb:6SOI|rcsb pdb:6SOT|rcsb pdb:6SOU|rcsb pdb:6SOV|rcsb pdb:6SP9|rcsb pdb:6SPL|rcsb pdb:6Y4T|rcsb pdb:6Y4U|rcsb pdb:6Y4V|rcsb pdb:6Y4W|rcsb pdb:6Y4X|rcsb pdb:6Y6V|rcsb pdb:6Y7W|rcsb pdb:6Y7X|rcsb pdb:6Y7Y|rcsb pdb:6Y7Z|rcsb pdb:6Y80|rcsb pdb:6Y81|rcsb pdb:6Y82|rcsb pdb:6Y85|rcsb pdb:6Y8H|rcsb pdb:6YCU|rcsb pdb:6YCW|rcsb pdb:6YJC|rcsb pdb:6YK7|rcsb pdb:6ZWR|rcsb pdb:7BDO|rcsb pdb:7BDQ|rcsb pdb:7BE4|rcsb pdb:7BE5|reactome:R-MMU-168638|reactome:R-MMU-171007|reactome:R-MMU-198753|reactome:R-MMU-2559580|reactome:R-MMU-376172|reactome:R-MMU-418592|reactome:R-MMU-432142|refseq:NP_001161980.1|refseq:NP_001161985.1|refseq:NP_001161986.1|refseq:NP_036081.1|dip:DIP-31073N	afcs:17113(primary-reference)|afcs:30821(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:iDZBrOVDDEDKOg968HyvA3hXWF810090	rogid:ks/9pIKb9SsZnYW71qj+5v5GVaw10090	intact-crc:535DCE3CDD4067A2|rigid:Iu8UXnCbxQbDtpgpQqO62HF8zNY	false	sufficient binding region:567-953	sufficient binding region:200-360	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70178	uniprotkb:Q9JM73	intact:EBI-645265|ensembl:ENSMUSP00000045973	intact:EBI-493266|ensembl:ENSMUSP00000015749	psi-mi:six5_mouse(display_long)|uniprotkb:DM locus-associated homeodomain protein homolog(gene name synonym)|uniprotkb:Six5(gene name)|psi-mi:Six5(display_short)|uniprotkb:Dmahp(gene name synonym)|uniprotkb:Sine oculis homeobox homolog 5(gene name synonym)	psi-mi:srf_mouse(display_long)|uniprotkb:Srf(gene name)|psi-mi:Srf(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654140	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_035513.1|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:1902723"(negative regulation of skeletal muscle satellite cell proliferation)|interpro:IPR001356(Homeobox)|interpro:IPR009057(Homeodomain-like)|interpro:IPR017970|interpro:IPR031701|ensembl:ENSMUST00000049454(transcript)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007286"(spermatid development)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|ensembl:ENSMUSG00000040841(gene)	refseq:NP_065239.1|ensembl:ENSMUSG00000015605(gene)|ensembl:ENSMUST00000015749(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001764"(neuron migration)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002521"(leukocyte differentiation)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009725"(response to hormone)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010736"(serum response element binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030038"(contractile actin filament bundle assembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030220"(platelet formation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046016"(positive regulation of transcription by glucose)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048589"(developmental growth)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060324"(face development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090398"(cellular senescence)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR033897|interpro:IPR036879|reactome:R-MMU-5663220|reactome:R-MMU-9031628|dip:DIP-49624N	afcs:18507(primary-reference)|afcs:33888(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Y6Cb3HRNXdjo2ZGZp1nX2sLcc4c10090	rogid:SQozUJAK6ZF0wewxfDKlanQwbaI10090	intact-crc:BA80DCC3AF04E9D4|rigid:6/cU49QSgtlpeFYKIcIpglZv7og	false	sufficient binding region:390-543	sufficient binding region:220-504	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3U1N2	uniprotkb:Q9JM73	intact:EBI-645275|uniprotkb:Q9ESZ4|uniprotkb:Q925C2|ensembl:ENSMUSP00000023100	intact:EBI-493266|ensembl:ENSMUSP00000015749	psi-mi:srbp2_mouse(display_long)|uniprotkb:Sterol regulatory element-binding transcription factor 2(gene name synonym)|uniprotkb:Srebf2(gene name)|psi-mi:Srebf2(display_short)|uniprotkb:Srebp2(gene name synonym)	psi-mi:srf_mouse(display_long)|uniprotkb:Srf(gene name)|psi-mi:Srf(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654160	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_150087.1|ensembl:ENSMUSG00000022463(gene)|ensembl:ENSMUST00000023100(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001227"(DNA-binding transcription repressor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008203"(cholesterol metabolic process)|go:"GO:0009267"(cellular response to starvation)|go:"GO:0009725"(response to hormone)|go:"GO:0010886"(positive regulation of cholesterol storage)|go:"GO:0012507"(ER to Golgi transport vesicle membrane)|go:"GO:0016020"(membrane)|go:"GO:0030425"(dendrite)|go:"GO:0032933"(SREBP signaling pathway)|go:"GO:0032937"(SREBP-SCAP-Insig complex)|go:"GO:0042632"(cholesterol homeostasis)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045542"(positive regulation of cholesterol biosynthetic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0070888"(E-box binding)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0090370"(negative regulation of cholesterol efflux)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR011598(Helix-loop-helix DNA-binding)|interpro:IPR036638|reactome:R-MMU-1655829|go:"GO:0008593"(regulation of Notch signaling pathway)	refseq:NP_065239.1|ensembl:ENSMUSG00000015605(gene)|ensembl:ENSMUST00000015749(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001569"(branching involved in blood vessel morphogenesis)|go:"GO:0001666"(response to hypoxia)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001707"(mesoderm formation)|go:"GO:0001764"(neuron migration)|go:"GO:0001829"(trophectodermal cell differentiation)|go:"GO:0001947"(heart looping)|go:"GO:0002011"(morphogenesis of an epithelial sheet)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0002521"(leukocyte differentiation)|go:"GO:0003257"(positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007015"(actin filament organization)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007369"(gastrulation)|go:"GO:0007507"(heart development)|go:"GO:0007616"(long-term memory)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008306"(associative learning)|go:"GO:0009725"(response to hormone)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0010735"(positive regulation of transcription via serum response element binding)|go:"GO:0010736"(serum response element binding)|go:"GO:0021766"(hippocampus development)|go:"GO:0022028"(tangential migration from the subventricular zone to the olfactory bulb)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030038"(contractile actin filament bundle assembly)|go:"GO:0030155"(regulation of cell adhesion)|go:"GO:0030168"(platelet activation)|go:"GO:0030220"(platelet formation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030878"(thyroid gland development)|go:"GO:0030900"(forebrain development)|go:"GO:0031175"(neuron projection development)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0033561"(regulation of water loss via skin)|go:"GO:0034097"(response to cytokine)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0035912"(dorsal aorta morphogenesis)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0043149"(stress fiber assembly)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0043589"(skin morphogenesis)|go:"GO:0045059"(positive thymic T cell selection)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045597"(positive regulation of cell differentiation)|go:"GO:0045773"(positive regulation of axon extension)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0045987"(positive regulation of smooth muscle contraction)|go:"GO:0046016"(positive regulation of transcription by glucose)|go:"GO:0046716"(muscle cell cellular homeostasis)|go:"GO:0048538"(thymus development)|go:"GO:0048589"(developmental growth)|go:"GO:0048821"(erythrocyte development)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051491"(positive regulation of filopodium assembly)|go:"GO:0055003"(cardiac myofibril assembly)|go:"GO:0060218"(hematopoietic stem cell differentiation)|go:"GO:0060261"(positive regulation of transcription initiation from RNA polymerase II promoter)|go:"GO:0060292"(long-term synaptic depression)|go:"GO:0060324"(face development)|go:"GO:0060347"(heart trabecula formation)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060532"(bronchus cartilage development)|go:"GO:0060534"(trachea cartilage development)|go:"GO:0060947"(cardiac vascular smooth muscle cell differentiation)|go:"GO:0061029"(eyelid development in camera-type eye)|go:"GO:0061145"(lung smooth muscle development)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0090009"(primitive streak formation)|go:"GO:0090136"(epithelial cell-cell adhesion)|go:"GO:0090398"(cellular senescence)|go:"GO:0098609"(cell-cell adhesion)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:1900222"(negative regulation of amyloid-beta clearance)|go:"GO:1902894"(negative regulation of miRNA transcription)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|interpro:IPR002100(Transcription factor, MADS-box)|interpro:IPR033897|interpro:IPR036879|reactome:R-MMU-5663220|reactome:R-MMU-9031628|dip:DIP-49624N	afcs:18507(primary-reference)|afcs:35117(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:uDjwj6tUHAmJizC11vcpYHK/sUc10090	rogid:SQozUJAK6ZF0wewxfDKlanQwbaI10090	intact-crc:BE414ACA30907B31|rigid:UFyDO/pRdUSZDpJOwJcZuvXJMt4	false	sufficient binding region:113-319	sufficient binding region:220-504	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q6F5E0	uniprotkb:P09055	intact:EBI-645317	intact:EBI-644224|uniprotkb:F6R105|uniprotkb:Q60993|uniprotkb:Q61126|uniprotkb:Q3TIW5|uniprotkb:Q3TWH6|uniprotkb:Q8BTU0|uniprotkb:Q8BVU1|ensembl:ENSMUSP00000087457	psi-mi:tm158_mouse(display_long)|uniprotkb:Ras-induced senescence protein 1(gene name synonym)|uniprotkb:40 kDa BINP-binding protein(gene name synonym)|uniprotkb:Tmem158(gene name)|psi-mi:Tmem158(display_short)|uniprotkb:Mbbp(gene name synonym)|uniprotkb:Ris1(gene name synonym)	psi-mi:itb1_mouse(display_long)|uniprotkb:Fibronectin receptor subunit beta(gene name synonym)|uniprotkb:VLA-4 subunit beta(gene name synonym)|uniprotkb:Itgb1(gene name)|psi-mi:Itgb1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654220	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR038962|go:"GO:0016021"(integral component of membrane)|go:"GO:0042277"(peptide binding)	refseq:NP_034708.1|ensembl:ENSMUSG00000025809(gene)|ensembl:ENSMUST00000090006(transcript)|go:"GO:0000082"(G1/S transition of mitotic cell cycle)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001669"(acrosomal vesicle)|go:"GO:0001701"(in utero embryonic development)|go:"GO:0001708"(cell fate specification)|go:"GO:0001894"(tissue homeostasis)|go:"GO:0001968"(fibronectin binding)|go:"GO:0002020"(protease binding)|go:"GO:0002042"(cell migration involved in sprouting angiogenesis)|go:"GO:0003779"(actin binding)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005518"(collagen binding)|go:"GO:0005604"(basement membrane)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0005912"(adherens junction)|go:"GO:0005925"(focal adhesion)|go:"GO:0006909"(phagocytosis)|go:"GO:0007155"(cell adhesion)|go:"GO:0007159"(leukocyte cell-cell adhesion)|go:"GO:0007160"(cell-matrix adhesion)|go:"GO:0007161"(calcium-independent cell-matrix adhesion)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014704"(intercalated disc)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0008305"(integrin complex)|go:"GO:0008354"(germ cell migration)|go:"GO:0008542"(visual learning)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0009986"(cell surface)|go:"GO:0010710"(regulation of collagen catabolic process)|go:"GO:0010763"(positive regulation of fibroblast migration)|go:"GO:0010811"(positive regulation of cell-substrate adhesion)|go:"GO:0019900"(kinase binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0019960"(C-X3-C chemokine binding)|go:"GO:0021943"(formation of radial glial scaffolds)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030027"(lamellipodium)|go:"GO:0030030"(cell projection organization)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030056"(hemidesmosome)|go:"GO:0030175"(filopodium)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031175"(neuron projection development)|go:"GO:0031345"(negative regulation of cell projection organization)|go:"GO:0031589"(cell-substrate adhesion)|go:"GO:0031594"(neuromuscular junction)|go:"GO:0031623"(receptor internalization)|go:"GO:0032587"(ruffle membrane)|go:"GO:0032594"(protein transport within lipid bilayer)|go:"GO:0033627"(cell adhesion mediated by integrin)|go:"GO:0033631"(cell-cell adhesion mediated by integrin)|go:"GO:0034113"(heterotypic cell-cell adhesion)|go:"GO:0034665"(integrin alpha1-beta1 complex)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0034667"(integrin alpha3-beta1 complex)|reactome:R-MMU-445144|reactome:R-MMU-446343|reactome:R-MMU-8874081|reactome:R-MMU-8875513|reactome:R-MMU-9013149|reactome:R-MMU-9013404|go:"GO:0034674"(integrin alpha5-beta1 complex)|reactome:R-MMU-9013408|reactome:R-MMU-9013423|go:"GO:0034679"(integrin alpha9-beta1 complex)|go:"GO:0034680"(integrin alpha10-beta1 complex)|go:"GO:0034681"(integrin alpha11-beta1 complex)|go:"GO:0035024"(negative regulation of Rho protein signal transduction)|go:"GO:0035748"(myelin sheath abaxonal region)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042383"(sarcolemma)|go:"GO:0042470"(melanosome)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043235"(receptor complex)|go:"GO:0043236"(laminin binding)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045202"(synapse)|go:"GO:0045211"(postsynaptic membrane)|go:"GO:0045214"(sarcomere organization)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045665"(negative regulation of neuron differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045807"(positive regulation of endocytosis)|go:"GO:0046872"(metal ion binding)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0048333"(mesodermal cell differentiation)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048675"(axon extension)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0050839"(cell adhesion molecule binding)|go:"GO:0050901"(leukocyte tethering or rolling)|go:"GO:0051393"(alpha-actinin binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0051951"(positive regulation of glutamate uptake involved in transmission of nerve impulse)|go:"GO:0034677"(integrin alpha7-beta1 complex)|go:"GO:0055037"(recycling endosome)|go:"GO:0070830"(bicellular tight junction assembly)|go:"GO:0071404"(cellular response to low-density lipoprotein particle stimulus)|go:"GO:0071711"(basement membrane organization)|go:"GO:0090303"(positive regulation of wound healing)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097386"(glial cell projection)|go:"GO:0098639"(collagen binding involved in cell-matrix adhesion)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099055"(integral component of postsynaptic membrane)|go:"GO:0099699"(integral component of synaptic membrane)|go:"GO:0150003"(regulation of spontaneous synaptic transmission)|go:"GO:0150103"(reactive gliosis)|go:"GO:1901979"(regulation of inward rectifier potassium channel activity)|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1990782"(protein tyrosine kinase binding)|go:"GO:2000273"(positive regulation of signaling receptor activity)|go:"GO:2000811"(negative regulation of anoikis)|interpro:IPR002369(Integrin beta subunit, N-terminal)|interpro:IPR012896(Integrin beta subunit, tail)|interpro:IPR013111(EGF, extracellular)|interpro:IPR014836(Integrin beta subunit, cytoplasmic)|interpro:IPR015812(Integrin beta subunit)|interpro:IPR016201(Plexin-like fold)|interpro:IPR027071|interpro:IPR032695|interpro:IPR033760|interpro:IPR036349|interpro:IPR036465|interpro:IPR040622|mint:P09055|rcsb pdb:5XQ0|reactome:R-MMU-1566948|reactome:R-MMU-1566977|reactome:R-MMU-198933|reactome:R-MMU-202733|reactome:R-MMU-210991|reactome:R-MMU-2129379|reactome:R-MMU-216083|reactome:R-MMU-3000157|reactome:R-MMU-3000170|reactome:R-MMU-3000178|go:"GO:0055007"(cardiac muscle cell differentiation)|dip:DIP-46247N	afcs:18892(primary-reference)|afcs:18892(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JGR2NiDmjrv92CXOqmsbpneuYmw10090	rogid:jlfpHCJp8eLzWN+3rdIOSG7Ijas10090	intact-crc:DF39C109AE03B1E3|rigid:0SQf8C86XsS9ZXQeQXphd89tFOM	false	sufficient binding region:234-286	sufficient binding region:350-602	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K1I7	uniprotkb:Q99M51	intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651841	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:7326(primary-reference)|afcs:35608(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:11778D2A630F81B6|rigid:5QRWGjcsWm1y/YgbMv4toknc1Nw	false	sufficient binding region:226-361	sufficient binding region:1-377	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K1I7	uniprotkb:Q99M51	intact:EBI-644216|uniprotkb:Q3U0U8|ensembl:ENSMUSP00000092268|ensembl:ENSMUSP00000099740|ensembl:ENSMUSP00000099741	intact:EBI-642202|uniprotkb:O55032|uniprotkb:Q9Z279|intact:EBI-2642686|intact:EBI-643937|ensembl:ENSMUSP00000112221	psi-mi:wipf1_mouse(display_long)|uniprotkb:Wiskott-Aldrich syndrome protein-interacting protein(gene name synonym)|uniprotkb:Wipf1(gene name)|psi-mi:Wipf1(display_short)|uniprotkb:Wip(gene name synonym)|uniprotkb:Waspip(gene name synonym)	psi-mi:nck1_mouse(display_long)|uniprotkb:Nck1(gene name)|psi-mi:Nck1(display_short)|uniprotkb:NCK adaptor protein 1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-651851	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_694778.1|refseq:NP_001276651.1|refseq:NP_001276652.1|ensembl:ENSMUSG00000075284(gene)|ensembl:ENSMUST00000094681(transcript)|ensembl:ENSMUST00000102679(transcript)|ensembl:ENSMUST00000102680(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0003779"(actin binding)|go:"GO:0005884"(actin filament)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030048"(actin filament-based movement)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0046827"(positive regulation of protein export from nucleus)|go:"GO:0051707"(response to other organism)|interpro:IPR003124(Actin-binding WH2)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR028295|mint:Q8K1I7|reactome:R-MMU-2029482|reactome:R-MMU-5663213|refseq:XP_006499187.1|refseq:XP_006499190.1|refseq:XP_011237735.1|dip:DIP-37798N	refseq:NP_035008.2|refseq:XP_006510903.1|ensembl:ENSMUSG00000032475(gene)|ensembl:ENSMUST00000116522(transcript)|go:"GO:0000164"(protein phosphatase type 1 complex)|go:"GO:0004860"(protein kinase inhibitor activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005840"(ribosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006930"(substrate-dependent cell migration, cell extension)|go:"GO:0007015"(actin filament organization)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0012506"(vesicle membrane)|go:"GO:0016477"(cell migration)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030032"(lamellipodium assembly)|go:"GO:0030334"(regulation of cell migration)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0030838"(positive regulation of actin filament polymerization)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0036493"(positive regulation of translation in response to endoplasmic reticulum stress)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042110"(T cell activation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046627"(negative regulation of insulin receptor signaling pathway)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048013"(ephrin receptor signaling pathway)|go:"GO:0051707"(response to other organism)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0070262"(peptidyl-serine dephosphorylation)|go:"GO:0071074"(eukaryotic initiation factor eIF2 binding)|go:"GO:1902237"(positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)|go:"GO:1903676"(positive regulation of cap-dependent translational initiation)|go:"GO:1903679"(positive regulation of cap-independent translational initiation)|go:"GO:1903898"(negative regulation of PERK-mediated unfolded protein response)|go:"GO:1903912"(negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation)|go:"GO:1990441"(negative regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)|interpro:IPR000980(SH2 motif)|interpro:IPR001452(Src homology-3)|interpro:IPR017304(Cytoplasmic, NCK)|interpro:IPR028526|interpro:IPR035562|interpro:IPR035564|interpro:IPR035565|interpro:IPR035882|interpro:IPR036028|interpro:IPR036860|reactome:R-MMU-186763|reactome:R-MMU-202433|reactome:R-MMU-2029482|reactome:R-MMU-373753|reactome:R-MMU-418885|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013420|reactome:R-MMU-9013424|reactome:R-MMU-983695|dip:DIP-37524N	afcs:7326(primary-reference)|afcs:35608(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:+MJIlqhSgZh/kkeKDo5zLhWuLeA10090	rogid:uq7YGxP9zh6bhhrOJdJa9D+3O2g10090	intact-crc:4A0E717D3933B9FB|rigid:5QRWGjcsWm1y/YgbMv4toknc1Nw	false	sufficient binding region:280-461	sufficient binding region:1-377	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P61979-1	uniprotkb:P25911	intact:EBI-1453334|ensembl:ENSMUSP00000039269|uniprotkb:Q07244-1	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:p61979-1(display_long)|uniprotkb:Hnrnpk(gene name)|psi-mi:Hnrnpk(display_short)|uniprotkb:Hnrpk(gene name synonym)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-658993	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000021546(gene)|ensembl:ENSMUST00000043269(transcript)|intact:EBI-299907(isoform-parent)	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	afcs:7137(primary-reference)|afcs:24767(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:YZQD5JJkHPUMtZ4XUA9fQkNfXzc10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:CC149F07BC5E623C|rigid:TVV3ZyfPP74VNSs3OgVQ+OdPQvM	false	sufficient binding region:111-458	sufficient binding region:60-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q64355	uniprotkb:P25911	intact:EBI-647907|uniprotkb:Q8BSX4|ensembl:ENSMUSP00000022813	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:efs_mouse(display_long)|uniprotkb:Signal-integrating protein(gene name synonym)|uniprotkb:SRC-interacting protein(gene name synonym)|uniprotkb:Efs(gene name)|psi-mi:Efs(display_short)|uniprotkb:Sin(gene name synonym)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659003	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034242.2|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0090527"(actin filament reorganization)|interpro:IPR001452(Src homology-3)|interpro:IPR021901|interpro:IPR035747|interpro:IPR036028|interpro:IPR037362|ensembl:ENSMUSG00000022203(gene)|ensembl:ENSMUST00000022813(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	afcs:7137(primary-reference)|afcs:9773(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:d8wLjEIN550CIYfjhspzngsmOas10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:0B596E39C752F36A|rigid:F5PRHmEkrEtdPsEBgGdq8rWAbbA	false	sufficient binding region:302-560	sufficient binding region:60-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91WK7	uniprotkb:P25911	intact:EBI-647914|uniprotkb:Q3UPC5|uniprotkb:Q3UZL7|ensembl:ENSMUSP00000047042	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:anr54_mouse(display_long)|uniprotkb:Ankrd54(gene name)|psi-mi:Ankrd54(display_short)|uniprotkb:Liar(gene name synonym)|uniprotkb:Lyn-interacting ankyrin repeat protein(gene name synonym)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659013	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659098.1|ensembl:ENSMUSG00000033055(gene)|ensembl:ENSMUST00000040676(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006913"(nucleocytoplasmic transport)|go:"GO:0019887"(protein kinase regulator activity)|go:"GO:0030496"(midbody)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:1902531"(regulation of intracellular signal transduction)|interpro:IPR002110(Ankyrin)|interpro:IPR036770	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	afcs:7137(primary-reference)|afcs:7137(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:c9kYWjbA+UFKS8Lhu0WO9c10iUk10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:15182E359BA731AF|rigid:Zei7H4AxMnMvaDXuQhEvDPJcrKk	false	sufficient binding region:90-276	sufficient binding region:60-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z0Z7	uniprotkb:P25911	intact:EBI-647919|uniprotkb:Q9JMI2|ensembl:ENSMUSP00000005279	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:klf5_mouse(display_long)|uniprotkb:Intestinal-enriched krueppel-like factor(gene name synonym)|uniprotkb:Transcription factor BTEB2(gene name synonym)|uniprotkb:Basic transcription element-binding protein 2(gene name synonym)|uniprotkb:Klf5(gene name)|psi-mi:Klf5(display_short)|uniprotkb:Bteb2(gene name synonym)|uniprotkb:Iklf(gene name synonym)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-659023	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033899.2|dip:DIP-49582N|ensembl:ENSMUSG00000005148(gene)|ensembl:ENSMUST00000005279(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001525"(angiogenesis)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0014816"(skeletal muscle satellite cell differentiation)|go:"GO:0014901"(satellite cell activation involved in skeletal muscle regeneration)|go:"GO:0014908"(myotube differentiation involved in skeletal muscle regeneration)|go:"GO:0030033"(microvillus assembly)|go:"GO:0032534"(regulation of microvillus assembly)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043403"(skeletal muscle tissue regeneration)|go:"GO:0043426"(MRF binding)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0045600"(positive regulation of fat cell differentiation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046872"(metal ion binding)|go:"GO:0060576"(intestinal epithelial cell development)|go:"GO:0061586"(positive regulation of transcription by transcription factor localization)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0099156"(cell-cell signaling via exosome)|go:"GO:1901653"(cellular response to peptide)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1990830"(cellular response to leukemia inhibitory factor)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)|go:"GO:2000723"(negative regulation of cardiac vascular smooth muscle cell differentiation)|interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR030401|interpro:IPR036236|mint:Q9Z0Z7	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	afcs:7137(primary-reference)|afcs:15736(secondary-ac)	-	-	caution:The prey construct contains 35 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jxgbCaFB4L8JIVdagGl2JZ/PxxQ10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:0C4BF5E2702AE9EF|rigid:lX0LZyW/quzXIaXD8raU15FOGuI	false	sufficient binding region:1-228	sufficient binding region:60-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:B9EKI5	uniprotkb:P25911	intact:EBI-682463|ensembl:ENSMUSP00000110115|ensembl:ENSMUSP00000154583	intact:EBI-643537|uniprotkb:Q62127|ensembl:ENSMUSP00000038838	psi-mi:b9eki5_mouse(display_long)|uniprotkb:Cblb(gene name)|psi-mi:Cblb(display_short)	psi-mi:lyn_mouse(display_long)|uniprotkb:Lyn(gene name)|psi-mi:Lyn(display_short)|uniprotkb:V-yes-1 Yamaguchi sarcoma viral related oncogene homolog(gene name synonym)|uniprotkb:p53Lyn(gene name synonym)|uniprotkb:p56Lyn(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688631	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001028410.1|refseq:XP_006522014.1|ensembl:ENSMUSG00000022637(gene)|ensembl:ENSMUST00000114471(transcript)|ensembl:ENSMUST00000227062(transcript)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0023051"(regulation of signaling)|go:"GO:0047690"(aspartyltransferase activity)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR003153(Adaptor protein Cbl, N-terminal helical)|interpro:IPR011992(EF-Hand type)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR014741(Adaptor protein Cbl, EF hand-like)|interpro:IPR014742(Adaptor protein Cbl, SH2-like)|interpro:IPR015940(Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote)|interpro:IPR017907|interpro:IPR024159|interpro:IPR024162|interpro:IPR036537|interpro:IPR036860|interpro:IPR039520	refseq:NP_001104566.1|go:"GO:0019899"(enzyme binding)|go:"GO:0030061"(mitochondrial crista)|go:"GO:0030097"(hemopoiesis)|go:"GO:0030154"(cell differentiation)|go:"GO:0030218"(erythrocyte differentiation)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030889"(negative regulation of B cell proliferation)|go:"GO:0031175"(neuron projection development)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0031966"(mitochondrial membrane)|go:"GO:0032868"(response to insulin)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033003"(regulation of mast cell activation)|go:"GO:0033628"(regulation of cell adhesion mediated by integrin)|go:"GO:0034136"(negative regulation of toll-like receptor 2 signaling pathway)|go:"GO:0034142"(toll-like receptor 4 signaling pathway)|go:"GO:0034144"(negative regulation of toll-like receptor 4 signaling pathway)|go:"GO:0034605"(cellular response to heat)|go:"GO:0034666"(integrin alpha2-beta1 complex)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042327"(positive regulation of phosphorylation)|go:"GO:0042493"|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042541"(hemoglobin biosynthetic process)|go:"GO:0043015"(gamma-tubulin binding)|go:"GO:0043200"(response to amino acid)|go:"GO:0043208"(glycosphingolipid binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|ensembl:ENSMUSG00000042228(gene)|ensembl:ENSMUST00000041377(transcript)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001817"(regulation of cytokine production)|go:"GO:0001933"(negative regulation of protein phosphorylation)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002431"(Fc receptor mediated stimulatory signaling pathway)|go:"GO:0002513"(tolerance induction to self antigen)|go:"GO:0002553"(histamine secretion by mast cell)|go:"GO:0002576"(platelet degranulation)|go:"GO:0002762"(negative regulation of myeloid leukocyte differentiation)|go:"GO:0002768"(immune response-regulating cell surface receptor signaling pathway)|go:"GO:0002774"(Fc receptor mediated inhibitory signaling pathway)|go:"GO:0002902"(regulation of B cell apoptotic process)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004713"(protein tyrosine kinase activity)|go:"GO:0004714"(transmembrane receptor protein tyrosine kinase activity)|go:"GO:0004715"(non-membrane spanning protein tyrosine kinase activity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005128"(erythropoietin receptor binding)|go:"GO:0005161"(platelet-derived growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005758"(mitochondrial intermembrane space)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005912"(adherens junction)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0006991"(response to sterol depletion)|go:"GO:0007165"(signal transduction)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009725"(response to hormone)|go:"GO:0009743"(response to carbohydrate)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0014003"(oligodendrocyte development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0014070"(response to organic cyclic compound)|go:"GO:0016020"(membrane)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0070304"(positive regulation of stress-activated protein kinase signaling cascade)|go:"GO:0070372"(regulation of ERK1 and ERK2 cascade)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0070447"(positive regulation of oligodendrocyte progenitor proliferation)|go:"GO:0070667"(negative regulation of mast cell proliferation)|go:"GO:0070668"(positive regulation of mast cell proliferation)|go:"GO:0071300"(cellular response to retinoic acid)|go:"GO:0090025"(regulation of monocyte chemotaxis)|go:"GO:0090330"(regulation of platelet aggregation)|go:"GO:0097028"(dendritic cell differentiation)|go:"GO:0099091"(postsynaptic specialization, intracellular component)|go:"GO:0140031"(phosphorylation-dependent protein binding)|go:"GO:1902532"(negative regulation of intracellular signal transduction)|go:"GO:1902961"(positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process)|go:"GO:2000670"(positive regulation of dendritic cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR000980(SH2 motif)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0098978"(glutamatergic synapse)|interpro:IPR001245(Tyrosine protein kinase)|interpro:IPR001452(Src homology-3)|interpro:IPR008266(Tyrosine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|go:"GO:0043552"(positive regulation of phosphatidylinositol 3-kinase activity)|go:"GO:0044325"(transmembrane transporter binding)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045087"(innate immune response)|go:"GO:0045121"(membrane raft)|go:"GO:0045646"(regulation of erythrocyte differentiation)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046875"(ephrin receptor binding)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048678"(response to axon injury)|go:"GO:0050727"(regulation of inflammatory response)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0050855"(regulation of B cell receptor signaling pathway)|go:"GO:0051219"(phosphoprotein binding)|go:"GO:0051272"(positive regulation of cellular component movement)|go:"GO:0051279"(regulation of release of sequestered calcium ion into cytosol)|go:"GO:0060252"(positive regulation of glial cell proliferation)|go:"GO:0060369"(positive regulation of Fc receptor mediated stimulatory signaling pathway)|go:"GO:0043407"(negative regulation of MAP kinase activity)|reactome:R-MMU-2871837|reactome:R-MMU-389356|reactome:R-MMU-389513|reactome:R-MMU-3928662|reactome:R-MMU-3928663|reactome:R-MMU-3928665|reactome:R-MMU-5621480|reactome:R-MMU-5621575|reactome:R-MMU-5690714|reactome:R-MMU-69231|reactome:R-MMU-75892|reactome:R-MMU-9027276|reactome:R-MMU-9027284|reactome:R-MMU-912631|reactome:R-MMU-9674555|reactome:R-MMU-9705462|reactome:R-MMU-982772|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR035748|interpro:IPR035852|interpro:IPR036028|interpro:IPR036860|mint:P25911|rcsb pdb:2ZV7|rcsb pdb:2ZV8|rcsb pdb:2ZV9|rcsb pdb:2ZVA|rcsb pdb:4TZI|reactome:R-MMU-114604|reactome:R-MMU-1433557|reactome:R-MMU-1433559|reactome:R-MMU-202733|reactome:R-MMU-2029481|reactome:R-MMU-210990|reactome:R-MMU-2454202|reactome:R-MMU-2730905|interpro:IPR020635|reactome:R-MMU-2871796|reactome:R-MMU-2871809|dip:DIP-37806N	afcs:20358(secondary-ac)|afcs:7137(primary-reference)	comment:"AfCS Y2H protein 20358. Sequence deduced from cross-reference: protein GI: 20894431, replaced by protein GI: 51769670."|comment:"similat to rat Casitas B-lineage lymphoma b; Cbl-b protein (98%)"	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/a/ZrHmGa1+dJMyubsxdzGfCrdQ10090	rogid:LjzRpfHDK7fzcRGOrdNV3LH/N2U10090	intact-crc:584B9063C376940D|rigid:xlewpAHlkgkTjn8qgpUILBfKHmo	false	sufficient binding region:328-412	sufficient binding region:60-130	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51807	uniprotkb:Q01815-1	intact:EBI-642797|uniprotkb:Q5M8S6|ensembl:ENSMUSP00000137171|ensembl:ENSMUSP00000135978|ensembl:ENSMUSP00000090644|ensembl:ENSMUSP00000127990	intact:EBI-644929|ensembl:ENSMUSP00000075021|ensembl:ENSMUSP00000077433	psi-mi:dylt1_mouse(display_long)|uniprotkb:T-complex testis-specific protein 1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym)|uniprotkb:Tctex1(gene name synonym)|uniprotkb:Tctex-1(gene name synonym)|uniprotkb:Dynlt1(gene name)|psi-mi:Dynlt1(display_short)|uniprotkb:Activator of G-protein signaling 2(gene name synonym)|uniprotkb:Tctel1(gene name synonym)	psi-mi:q01815-1(display_long)|uniprotkb:CACH2A(isoform synonym)|uniprotkb:Cacna1c(gene name)|psi-mi:Cacna1c(display_short)|uniprotkb:Cach2(gene name synonym)|uniprotkb:Cacn2(gene name synonym)|uniprotkb:Cacnl1a1(gene name synonym)|uniprotkb:Cchl1a1(gene name synonym)|uniprotkb:Calcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscle(gene name synonym)|uniprotkb:MELC-CC(gene name synonym)|uniprotkb:Mouse brain class C(gene name synonym)|uniprotkb:Voltage-gated calcium channel subunit alpha Cav1.2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653326	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001160099.1|refseq:NP_001160101.1|refseq:NP_001160102.1|refseq:NP_033368.1|ensembl:ENSMUST00000092966(transcript)|ensembl:ENSMUST00000169415(transcript)|ensembl:ENSMUST00000179554(transcript)|ensembl:ENSMUST00000179569(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0099503"(secretory vesicle)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|mint:P51807|rcsb pdb:5WI4|reactome:R-MMU-6798695|go:"GO:0030742"(GTP-dependent protein binding)|ensembl:ENSMUSG00000000579(gene)|ensembl:ENSMUSG00000092074(gene)|ensembl:ENSMUSG00000095677(gene)|ensembl:ENSMUSG00000096255(gene)|refseq:XP_017172676.1	intact:EBI-644904(cac1c_mouse)|ensembl:ENSMUSG00000051331(gene)|ensembl:ENSMUST00000075591(transcript)|ensembl:ENSMUST00000078320(transcript)	afcs:9401(secondary-ac)|afcs:15745(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fn6QN4J3aA++93iJwG3rFDjPBvM10090	rogid:fl3WWY9hkShz2t1DpMRNX0t2OgU10090	intact-crc:D14BB4E4FF4A73D4|rigid:4b0UrIVsZ6+7im28kv56rlKcpW0	false	sufficient binding region:1-113	sufficient binding region:1700-1975	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q810A7	uniprotkb:Q9Z2A0	intact:EBI-642967|ensembl:ENSMUSP00000021046|uniprotkb:Q3TAN3|uniprotkb:Q3TE60|uniprotkb:Q8BWZ7|uniprotkb:Q9D8Q2	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:ddx42_mouse(display_long)|uniprotkb:DEAD box protein 42(gene name synonym)|uniprotkb:Ddx42(gene name)|psi-mi:Ddx42(display_short)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650510	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000020705(gene)|ensembl:ENSMUST00000021046(transcript)|go:"GO:0003723"(RNA binding)|go:"GO:0003724"(RNA helicase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0008104"(protein localization)|go:"GO:0015030"(Cajal body)|go:"GO:0016607"(nuclear speck)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0140603"(obsolete ATP hydrolysis activity)|interpro:IPR000629(RNA helicase, ATP-dependent, DEAD-box, conserved site)|interpro:IPR001650(DNA/RNA helicase, C-terminal)|interpro:IPR011545(DNA/RNA helicase, DEAD/DEAH box type, N-terminal)|interpro:IPR014001(DEAD-like helicase, N-terminal)|interpro:IPR014014(RNA helicase, DEAD-box type, Q motif)|refseq:NP_082350.3|interpro:IPR027417|mint:Q810A7|reactome:R-MMU-72163|reactome:R-MMU-72165	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:34637(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fNeWrnbWicNqyoy+Vc1d0YVu69810090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:2A395F9DAFC57329|rigid:BjM2VRXagFwv+jvuQgJZDkymgk8	false	sufficient binding region:244-356	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91YQ5	uniprotkb:Q9Z2A0	intact:EBI-642977|uniprotkb:Q3U985|ensembl:ENSMUSP00000032143	intact:EBI-400345|uniprotkb:Q9R1D8|uniprotkb:Q9R215|uniprotkb:A6H6U3|ensembl:ENSMUSP00000099991	psi-mi:rpn1_mouse(display_long)|uniprotkb:Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 67 kDa subunit(gene name synonym)|uniprotkb:Ribophorin-1(gene name synonym)|uniprotkb:Ribophorin I(gene name synonym)|uniprotkb:Rpn1(gene name)|psi-mi:Rpn1(display_short)	psi-mi:pdpk1_mouse(display_long)|uniprotkb:Pdpk1(gene name)|psi-mi:Pdpk1(display_short)|uniprotkb:Pdk1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650520	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598694.3|ensembl:ENSMUSG00000030062(gene)|ensembl:ENSMUST00000032143(transcript)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005791"(rough endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0006487"(protein N-linked glycosylation)|go:"GO:0008250"(oligosaccharyltransferase complex)|go:"GO:0016021"(integral component of membrane)|go:"GO:0018279"(protein N-linked glycosylation via asparagine)|go:"GO:0042470"(melanosome)|interpro:IPR007676(Ribophorin I)|mint:Q91YQ5	refseq:NP_035192.2|ensembl:ENSMUSG00000024122(gene)|ensembl:ENSMUST00000102927(transcript)|go:"GO:0003323"(type B pancreatic cell development)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004676"(3-phosphoinositide-dependent protein kinase activity)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006469"(negative regulation of protein kinase activity)|go:"GO:0006972"(hyperosmotic response)|go:"GO:0007165"(signal transduction)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0010518"(positive regulation of phospholipase activity)|go:"GO:0010594"(regulation of endothelial cell migration)|go:"GO:0010667"(negative regulation of cardiac muscle cell apoptotic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016004"(phospholipase activator activity)|go:"GO:0016477"(cell migration)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019722"(calcium-mediated signaling)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030512"(negative regulation of transforming growth factor beta receptor signaling pathway)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032869"(cellular response to insulin stimulus)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042995"(cell projection)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR033931|interpro:IPR039046|mint:Q9Z2A0|reactome:R-MMU-114604|reactome:R-MMU-1257604|reactome:R-MMU-165158|reactome:R-MMU-202424|reactome:R-MMU-2730905|reactome:R-MMU-2871837|reactome:R-MMU-354192|reactome:R-MMU-389357|reactome:R-MMU-392451|reactome:R-MMU-5218920|reactome:R-MMU-5218921|reactome:R-MMU-5607764|reactome:R-MMU-5625740|reactome:R-MMU-6804757|reactome:R-MMU-9634635|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043204"(perikaryon)|go:"GO:0043274"(phospholipase binding)|go:"GO:0043304"(regulation of mast cell degranulation)|go:"GO:0043524"(negative regulation of neuron apoptotic process)|go:"GO:0043536"(positive regulation of blood vessel endothelial cell migration)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0048041"(focal adhesion assembly)|go:"GO:0051281"(positive regulation of release of sequestered calcium ion into cytosol)|go:"GO:0071364"(cellular response to epidermal growth factor stimulus)|go:"GO:0097191"(extrinsic apoptotic signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1903078"(positive regulation of protein localization to plasma membrane)|go:"GO:1903672"(positive regulation of sprouting angiogenesis)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1990416"(cellular response to brain-derived neurotrophic factor stimulus)|go:"GO:2000352"(negative regulation of endothelial cell apoptotic process)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)	afcs:16541(primary-reference)|afcs:34639(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fkMLaj/vo2SbXmURvjhv896RtZ410090	rogid:xtiYItB0ax0L6bm4mrjVToLmGZc10090	intact-crc:6B2D828469C171D8|rigid:3ed1fPLfkGMpJlhkR4r7Y2Rg2tg	false	sufficient binding region:153-382	sufficient binding region:340-559	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QZH6	uniprotkb:P70196	intact:EBI-527020|uniprotkb:Q91V53	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:ecsit_mouse(display_long)|uniprotkb:Protein SITPEC(gene name synonym)|uniprotkb:Ecsit(gene name)|psi-mi:Ecsit(display_short)|uniprotkb:Sitpec(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-648555	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_036159.1|refseq:XP_011240840.1|refseq:XP_006510433.1|refseq:NP_001240826.1|refseq:NP_001240827.1|go:"GO:0005739"(mitochondrion)|go:"GO:0001707"(mesoderm formation)|go:"GO:0003682"(chromatin binding)|go:"GO:0005829"(cytosol)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0007178"(transmembrane receptor protein serine/threonine kinase signaling pathway)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045087"(innate immune response)|go:"GO:0051341"(regulation of oxidoreductase activity)|go:"GO:0061635"(regulation of protein complex stability)|interpro:IPR010418(ECSIT)|interpro:IPR029342|dip:DIP-33901N|reactome:R-MMU-166058|reactome:R-MMU-6799198|reactome:R-MMU-975138|reactome:R-MMU-975871	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:11847(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:OJosVT4SJO/B9WEMImjhVyFef3Q10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:A88BC730CCC4A666|rigid:vuhPXY9OzGnJftEFCLbDfTJvfVE	false	sufficient binding region:83-435	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91WA6	uniprotkb:P39429	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655453	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:55436(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:B268DFE03D337895|rigid:bgBtnJKhW9Xi/pTpXrdAGabDHCA	false	sufficient binding region:107-330	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91WA6	uniprotkb:P39429	intact:EBI-646097|uniprotkb:Q7TNT3|uniprotkb:Q8CHL3|ensembl:ENSMUSP00000023211	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:shrpn_mouse(display_long)|uniprotkb:Shank-associated RH domain-interacting protein(gene name synonym)|uniprotkb:Shank-interacting protein-like 1(gene name synonym)|uniprotkb:Sharpin(gene name)|psi-mi:Sharpin(display_short)|uniprotkb:Sipl1(gene name synonym)|uniprotkb:Cpdm(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655463	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_079616.2|dip:DIP-49461N|go:"GO:0007005"(mitochondrion organization)|go:"GO:0007420"(brain development)|go:"GO:0008544"(epidermis development)|go:"GO:0010803"(regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:0014069"(postsynaptic density)|go:"GO:0030262"(apoptotic nuclear changes)|go:"GO:0030425"(dendrite)|go:"GO:0031424"(keratinization)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043130"(ubiquitin binding)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0046872"(metal ion binding)|go:"GO:0050728"(negative regulation of inflammatory response)|go:"GO:0071797"(LUBAC complex)|go:"GO:0097039"(protein linear polyubiquitination)|go:"GO:2000348"(regulation of CD40 signaling pathway)|interpro:IPR001876(Zinc finger, RanBP2-type)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR026261|interpro:IPR029071|interpro:IPR031912|interpro:IPR036443|rcsb pdb:5Y3T|reactome:R-MMU-5357905|reactome:R-MMU-5357956|ensembl:ENSMUSG00000022552(gene)|ensembl:ENSMUST00000023211(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005829"(cytosol)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:55436(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:X0S3ADbUc34U7NHcxNjatvqgE2010090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:D4B5E17A7A122040|rigid:bgBtnJKhW9Xi/pTpXrdAGabDHCA	false	sufficient binding region:132-349	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P39429	uniprotkb:Q6PFD9	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-646104|uniprotkb:Q68G59	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:nup98_mouse(display_long)|uniprotkb:Nup98(gene name)|psi-mi:Nup98(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655473	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	interpro:IPR021967|rcsb pdb:3TKN|refseq:NP_075355.1|interpro:IPR007230(Peptidase S59, nucleoporin)|refseq:NP_001274093.1|refseq:NP_001274094.1|interpro:IPR037665|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042277"(peptide binding)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR036903|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-191859|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4615885|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-170822|reactome:R-MMU-3232142|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-5578749|reactome:R-MMU-9648025|reactome:R-MMU-9615933|interpro:IPR037637	afcs:53738(primary-reference)|afcs:53738(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:xpADUMqRI2bAH6d/gdlx0T3X6MA10090	intact-crc:B1E9145EAABE93F2|rigid:46/fHIo7nIff9TJsiv5WYJZUceE	false	sufficient binding region:233-353	sufficient binding region:108-793	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P39429	uniprotkb:Q6PFD9	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-646104|uniprotkb:Q68G59	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:nup98_mouse(display_long)|uniprotkb:Nup98(gene name)|psi-mi:Nup98(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655483	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	interpro:IPR021967|rcsb pdb:3TKN|refseq:NP_075355.1|interpro:IPR007230(Peptidase S59, nucleoporin)|refseq:NP_001274093.1|refseq:NP_001274094.1|interpro:IPR037665|go:"GO:0003713"(transcription coactivator activity)|go:"GO:0003729"(mRNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005643"(nuclear pore)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0008139"(nuclear localization sequence binding)|go:"GO:0008236"(serine-type peptidase activity)|go:"GO:0016604"(nuclear body)|go:"GO:0017056"(structural constituent of nuclear pore)|go:"GO:0031080"(nuclear pore outer ring)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034399"(nuclear periphery)|go:"GO:0042277"(peptide binding)|go:"GO:0042405"(nuclear inclusion body)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044615"(nuclear pore nuclear basket)|go:"GO:0048026"(positive regulation of mRNA splicing, via spliceosome)|go:"GO:0051028"(mRNA transport)|go:"GO:0051292"(nuclear pore complex assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|go:"GO:1990904"(ribonucleoprotein complex)|interpro:IPR036903|reactome:R-MMU-141444|reactome:R-MMU-159227|reactome:R-MMU-159230|reactome:R-MMU-159231|reactome:R-MMU-159236|reactome:R-MMU-191859|reactome:R-MMU-2467813|reactome:R-MMU-2500257|reactome:R-MMU-3108214|reactome:R-MMU-3301854|reactome:R-MMU-3371453|reactome:R-MMU-4615885|reactome:R-MMU-5663220|reactome:R-MMU-68877|reactome:R-MMU-170822|reactome:R-MMU-3232142|reactome:R-MMU-4085377|reactome:R-MMU-4551638|reactome:R-MMU-4570464|reactome:R-MMU-5578749|reactome:R-MMU-9648025|reactome:R-MMU-9615933|interpro:IPR037637	afcs:53738(primary-reference)|afcs:55517(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:xpADUMqRI2bAH6d/gdlx0T3X6MA10090	intact-crc:55BE0A33CBB03CF9|rigid:46/fHIo7nIff9TJsiv5WYJZUceE	false	sufficient binding region:233-353	sufficient binding region:180-709	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BXV2	uniprotkb:P39429	intact:EBI-646111|uniprotkb:Q8BXP1|uniprotkb:Q9CWE5|ensembl:ENSMUSP00000037609	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:bri3b_mouse(display_long)|uniprotkb:Bri3bp(gene name)|psi-mi:Bri3bp(display_short)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655493	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_084028.1|ensembl:ENSMUSG00000037905(gene)|ensembl:ENSMUST00000049040(transcript)|go:"GO:0005739"(mitochondrion)|go:"GO:0005741"(mitochondrial outer membrane)|go:"GO:0016021"(integral component of membrane)|interpro:IPR033367	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:55520(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:bd7CaxLp5zV0/QKMeMONvZEiKZE10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:C55718E5F29C49DE|rigid:CPn81Ch/it1s2PQ/f9hC37DJgcE	false	sufficient binding region:186-247	sufficient binding region:233-353	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39429	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655503	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 18 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:9824AD9F8354BEA5|rigid:zasCBbUD5WsoMLSoNC5925q7ak4	false	sufficient binding region:1-311	sufficient binding region:293-501	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39429	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655514	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 7 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:3472BC754F38AECE|rigid:zasCBbUD5WsoMLSoNC5925q7ak4	false	sufficient binding region:1-217	sufficient binding region:293-501	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39429	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655524	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 7 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:9E378EF9C97864D1|rigid:zasCBbUD5WsoMLSoNC5925q7ak4	false	sufficient binding region:1-230	sufficient binding region:293-501	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39429	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655534	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 6 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:78474887B67D11A2|rigid:zasCBbUD5WsoMLSoNC5925q7ak4	false	sufficient binding region:1-390	sufficient binding region:293-501	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70347-1	uniprotkb:P39429	intact:EBI-646125|ensembl:ENSMUSP00000077219	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:p70347-1(display_long)|uniprotkb:Beta(isoform synonym)|uniprotkb:Tank(gene name)|psi-mi:Tank(display_short)|uniprotkb:Itraf(gene name synonym)|uniprotkb:TRAF-interacting protein(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655544	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-646116(tank_mouse)|ensembl:ENSMUSG00000064289(gene)|ensembl:ENSMUST00000078074(transcript)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:16826(secondary-ac)	-	-	caution:The prey construct contains 2 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:PHOTssyAMm3MUY1hQfgJq+llEdM10090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:6336D00491DBA660|rigid:zasCBbUD5WsoMLSoNC5925q7ak4	false	sufficient binding region:1-371	sufficient binding region:293-501	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P70196	uniprotkb:Q62406-1	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655594	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:6999(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:F920C29FF08BC7D3|rigid:NcTkqDpX3fuJqYwrtGBR9nF1dy0	false	sufficient binding region:319-530	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51807	uniprotkb:Q62406-1	intact:EBI-642797|uniprotkb:Q5M8S6|ensembl:ENSMUSP00000137171|ensembl:ENSMUSP00000135978|ensembl:ENSMUSP00000090644|ensembl:ENSMUSP00000127990	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:dylt1_mouse(display_long)|uniprotkb:T-complex testis-specific protein 1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym)|uniprotkb:Tctex1(gene name synonym)|uniprotkb:Tctex-1(gene name synonym)|uniprotkb:Dynlt1(gene name)|psi-mi:Dynlt1(display_short)|uniprotkb:Activator of G-protein signaling 2(gene name synonym)|uniprotkb:Tctel1(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655615	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001160099.1|refseq:NP_001160101.1|refseq:NP_001160102.1|refseq:NP_033368.1|ensembl:ENSMUST00000092966(transcript)|ensembl:ENSMUST00000169415(transcript)|ensembl:ENSMUST00000179554(transcript)|ensembl:ENSMUST00000179569(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0099503"(secretory vesicle)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|mint:P51807|rcsb pdb:5WI4|reactome:R-MMU-6798695|go:"GO:0030742"(GTP-dependent protein binding)|ensembl:ENSMUSG00000000579(gene)|ensembl:ENSMUSG00000092074(gene)|ensembl:ENSMUSG00000095677(gene)|ensembl:ENSMUSG00000096255(gene)|refseq:XP_017172676.1	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:9401(secondary-ac)|afcs:14620(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fn6QN4J3aA++93iJwG3rFDjPBvM10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:CC0CE52B06CA90EC|rigid:xId3Qdcom3unULhUblmrgvrzcaQ	false	sufficient binding region:1-113	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CDG3	uniprotkb:Q62406-1	intact:EBI-646144|uniprotkb:Q7TMU9|uniprotkb:Q8BP90	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:vcip1_mouse(display_long)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein p135(gene name synonym)|uniprotkb:Valosin-containing protein p97/p47 complex-interacting protein 1(gene name synonym)|uniprotkb:Vcpip1(gene name)|psi-mi:Vcpip1(display_short)|uniprotkb:Vcip135(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655624	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR029071|refseq:NP_775619.2|interpro:IPR003323(Ovarian tumour, otubain)|mint:Q8CDG3|go:"GO:0000278"(mitotic cell cycle)|go:"GO:0004843"(thiol-dependent deubiquitinase)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005795"(Golgi stack)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007030"(Golgi organization)|go:"GO:0016320"(endoplasmic reticulum membrane fusion)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0016579"(protein deubiquitination)|go:"GO:0035871"(protein K11-linked deubiquitination)|go:"GO:0045202"(synapse)|go:"GO:0071108"(protein K48-linked deubiquitination)|go:"GO:0090168"(Golgi reassembly)|go:"GO:0106300"(protein-DNA covalent cross-linking repair)|go:"GO:1905634"(regulation of protein localization to chromatin)|reactome:R-MMU-5689896|interpro:IPR039087	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:55485(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jTwHlp3wXtIw4o5+Oqvb47HbKEk10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:16D41C6DC4575B12|rigid:gUzaKLfT2C9Zwmi7Oo+8TuU8g/E	false	sufficient binding region:838-1026	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8N7N6	uniprotkb:P70196	intact:EBI-646165|uniprotkb:Q8BH33|ensembl:ENSMUSP00000019987	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:ciks_mouse(display_long)|uniprotkb:Traf3ip2(gene name)|psi-mi:Traf3ip2(display_short)|uniprotkb:Adapter protein CIKS(gene name synonym)|uniprotkb:Connection to IKK and SAPK/JNK(gene name synonym)|uniprotkb:E3 ubiquitin-protein ligase CIKS(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B activator 1(gene name synonym)|uniprotkb:TRAF3-interacting protein 2(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655644	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598761.2|ensembl:ENSMUSG00000019842(gene)|ensembl:ENSMUST00000019987(transcript)|go:"GO:0000209"(protein polyubiquitination)|go:"GO:0001768"(establishment of T cell polarity)|go:"GO:0001782"(B cell homeostasis)|go:"GO:0001783"(B cell apoptotic process)|go:"GO:0001822"(kidney development)|go:"GO:0002230"(positive regulation of defense response to virus by host)|go:"GO:0002269"(leukocyte activation involved in inflammatory response)|go:"GO:0002334"(transitional two stage B cell differentiation)|go:"GO:0002344"(B cell affinity maturation)|go:"GO:0002447"(eosinophil mediated immunity)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0006954"(inflammatory response)|go:"GO:0006955"(immune response)|go:"GO:0006959"(humoral immune response)|go:"GO:0007507"(heart development)|go:"GO:0010467"(gene expression)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019724"(B cell mediated immunity)|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0023035"(CD40 signaling pathway)|go:"GO:0030217"(T cell differentiation)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0034504"(protein localization to nucleus)|go:"GO:0038173"(interleukin-17A-mediated signaling pathway)|go:"GO:0042092"(type 2 immune response)|go:"GO:0042110"(T cell activation)|go:"GO:0042119"(neutrophil activation)|go:"GO:0042493"|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043588"(skin development)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0048535"(lymph node development)|go:"GO:0048536"(spleen development)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070254"(mucus secretion)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097398"(cellular response to interleukin-17)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:0110012"(protein localization to P-body)|go:"GO:1990959"(eosinophil homeostasis)|interpro:IPR013568(SEFIR)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:55457(secondary-ac)	-	-	caution:The prey construct contains 2 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:5bulclSzhDkoS6yscEwLOSbhRi410090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:97B1DDF424E4711B|rigid:9gCKZQcgmYw5wMfxE1RsFjRypNM	false	sufficient binding region:1-138	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z1R2	uniprotkb:P70196	intact:EBI-644645|uniprotkb:Q8SNA3|ensembl:ENSMUSP00000025250	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:bag6_mouse(display_long)|uniprotkb:HLA-B-associated transcript 3(gene name synonym)|uniprotkb:Bat3(gene name synonym)|uniprotkb:BCL2-associated athanogene 6(gene name synonym)|uniprotkb:Bag6(gene name)|psi-mi:Bag6(display_short)|uniprotkb:BAG family molecular chaperone regulator 6(gene name synonym)|uniprotkb:Protein Scythe(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655654	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_476512.1|ensembl:ENSMUSG00000024392(gene)|ensembl:ENSMUST00000025250(transcript)|go:"GO:0001822"(kidney development)|go:"GO:0002429"(immune response-activating cell surface receptor signaling pathway)|go:"GO:0002474"(antigen processing and presentation of peptide antigen via MHC class I)|go:"GO:0005102"(signaling receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006325"(chromatin organization)|go:"GO:0006511"(ubiquitin-dependent protein catabolic process)|go:"GO:0006915"(apoptotic process)|go:"GO:0007130"(synaptonemal complex assembly)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007420"(brain development)|go:"GO:0010498"(proteasomal protein catabolic process)|go:"GO:0016020"(membrane)|go:"GO:0018393"(internal peptidyl-lysine acetylation)|go:"GO:0030101"(natural killer cell activation)|go:"GO:0030154"(cell differentiation)|go:"GO:0030324"(lung development)|go:"GO:0030433"(ubiquitin-dependent ERAD pathway)|go:"GO:0030544"(Hsp70 protein binding)|go:"GO:0031593"(polyubiquitin modification-dependent protein binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0032435"(negative regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042771"(intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043022"(ribosome binding)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043161"(proteasome-mediated ubiquitin-dependent protein catabolic process)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045861"(negative regulation of proteolysis)|go:"GO:0045995"(regulation of embryonic development)|go:"GO:0050821"(protein stabilization)|go:"GO:0051787"(misfolded protein binding)|go:"GO:0061857"(endoplasmic reticulum stress-induced pre-emptive quality control)|go:"GO:0070059"(intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)|go:"GO:0070062"(extracellular exosome)|go:"GO:0070628"(proteasome binding)|go:"GO:0071712"(ER-associated misfolded protein catabolic process)|go:"GO:0071816"(tail-anchored membrane protein insertion into ER membrane)|go:"GO:0071818"(BAT3 complex)|go:"GO:1904294"(positive regulation of ERAD pathway)|go:"GO:1904378"(maintenance of unfolded protein involved in ERAD pathway)|go:"GO:1990381"(ubiquitin-specific protease binding)|interpro:IPR000626(Ubiquitin)|interpro:IPR019954|interpro:IPR021925|interpro:IPR029071|mint:Q9Z1R2|dip:DIP-49391N	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:6999(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:psW3TZRi1goIL8R7JOGiBON/bk810090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:3648C93B5845A918|rigid:6pYWLd+M/1g8hbGjlJFBDa5xSdE	false	sufficient binding region:44-312	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D8Q6	uniprotkb:P70196	intact:EBI-646175|ensembl:ENSMUSP00000036912|ensembl:ENSMUSP00000137735	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:ck053_mouse(display_long)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655674	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081493.1|refseq:XP_006510651.1|refseq:XP_006510652.1|ensembl:ENSMUSG00000036027(gene)|ensembl:ENSMUST00000039959(transcript)|ensembl:ENSMUST00000181366(transcript)|interpro:IPR037655	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:55521(secondary-ac)	-	-	caution:The prey construct contains 83 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JGKRU7YUxprtPe4oyM6bu4D3p2s10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:95C631584BC2A1A1|rigid:T+1Jubt04ROloxdpKcpbojum8e8	false	sufficient binding region:1-235	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D8Q6	uniprotkb:P70196	intact:EBI-646175|ensembl:ENSMUSP00000036912|ensembl:ENSMUSP00000137735	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:ck053_mouse(display_long)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655685	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_081493.1|refseq:XP_006510651.1|refseq:XP_006510652.1|ensembl:ENSMUSG00000036027(gene)|ensembl:ENSMUST00000039959(transcript)|ensembl:ENSMUST00000181366(transcript)|interpro:IPR037655	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:55521(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JGKRU7YUxprtPe4oyM6bu4D3p2s10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:DC0D349561118279|rigid:T+1Jubt04ROloxdpKcpbojum8e8	false	sufficient binding region:107-235	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K4B2	uniprotkb:P70196	intact:EBI-646179|uniprotkb:Q8C7U8|uniprotkb:Q8CE40|uniprotkb:Q8K1S8|ensembl:ENSMUSP00000020448	intact:EBI-448028|ensembl:ENSMUSP00000004949|uniprotkb:Q8BLV2|uniprotkb:Q6P9M0	psi-mi:irak3_mouse(display_long)|uniprotkb:IL-1 receptor-associated kinase M(gene name synonym)|uniprotkb:Irak3(gene name)|psi-mi:Irak3(display_short)|uniprotkb:Inactive IL-1 receptor-associated kinase 3(gene name synonym)	psi-mi:traf6_mouse(display_long)|uniprotkb:RING-type E3 ubiquitin transferase TRAF6(gene name synonym)|uniprotkb:Traf6(gene name)|psi-mi:Traf6(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF6(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655695	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082955.2|go:"GO:0001960"(negative regulation of cytokine-mediated signaling pathway)|go:"GO:0002755"(MyD88-dependent toll-like receptor signaling pathway)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009615"(response to virus)|go:"GO:0010933"(positive regulation of macrophage tolerance induction)|go:"GO:0010936"(negative regulation of macrophage cytokine production)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019901"(protein kinase binding)|go:"GO:0032088"(negative regulation of NF-kappaB transcription factor activity)|go:"GO:0032494"(response to peptidoglycan)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032695"(negative regulation of interleukin-12 production)|go:"GO:0032715"(negative regulation of interleukin-6 production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034122"(negative regulation of toll-like receptor signaling pathway)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0042177"(negative regulation of protein catabolic process)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043242"(negative regulation of protein-containing complex disassembly)|go:"GO:0043244"(regulation of protein-containing complex disassembly)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043407"(negative regulation of MAP kinase activity)|go:"GO:0045824"(negative regulation of innate immune response)|go:"GO:0046777"(protein autophosphorylation)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070555"(response to interleukin-1)|interpro:IPR000488(Death)|interpro:IPR000719(Protein kinase, core)|interpro:IPR011009(Protein kinase-like)|interpro:IPR011029(DEATH-like)|interpro:IPR033610|interpro:IPR042698|interpro:IPR042747|mint:Q8K4B2|reactome:R-MMU-9020702|ensembl:ENSMUSG00000020227(gene)|ensembl:ENSMUST00000020448(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0001819"(positive regulation of cytokine production)	ensembl:ENSMUSG00000027164(gene)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000209"(protein polyubiquitination)|ensembl:ENSMUST00000004949(transcript)|go:"GO:0001503"(ossification)|go:"GO:0001701"(in utero embryonic development)|refseq:NP_033450.2|refseq:NP_001290202.1|go:"GO:0001843"(neural tube closure)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005811"(lipid droplet)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006955"(immune response)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007165"(signal transduction)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0007254"(JNK cascade)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|go:"GO:0019901"(protein kinase binding)|go:"GO:0030316"(osteoclast differentiation)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031624"(ubiquitin conjugating enzyme binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031666"(positive regulation of lipopolysaccharide-mediated signaling pathway)|go:"GO:0031996"(thioesterase binding)|dip:DIP-29812N|go:"GO:0032147"(activation of protein kinase activity)|go:"GO:0032735"(positive regulation of interleukin-12 production)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032813"(tumor necrosis factor receptor superfamily binding)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042088"(T-helper 1 type immune response)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042475"(odontogenesis of dentin-containing tooth)|go:"GO:0042802"(identical protein binding)|go:"GO:0042826"(histone deacetylase binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043422"(protein kinase B binding)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0045453"(bone resorption)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0061630"(ubiquitin protein ligase activity)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0071222"(cellular response to lipopolysaccharide)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1901224"(positive regulation of NIK/NF-kappaB signaling)|go:"GO:1904996"(positive regulation of leukocyte adhesion to vascular endothelial cell)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR027139|interpro:IPR037309|interpro:IPR041310|interpro:IPR043211|mint:P70196|reactome:R-MMU-1257604|reactome:R-MMU-166058|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|reactome:R-MMU-168638|reactome:R-MMU-193692|reactome:R-MMU-202424|reactome:R-MMU-205043|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-450302|reactome:R-MMU-450321|reactome:R-MMU-5607764|reactome:R-MMU-5689880|reactome:R-MMU-5689896|reactome:R-MMU-6811558|reactome:R-MMU-9020702|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-937042|reactome:R-MMU-937072|reactome:R-MMU-9645460|reactome:R-MMU-975138|go:"GO:0046330"(positive regulation of JNK cascade)|reactome:R-MMU-975144|reactome:R-MMU-975163|reactome:R-MMU-975871|go:"GO:0046849"(bone remodeling)|go:"GO:0047485"(protein N-terminus binding)|go:"GO:0048468"(cell development)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050852"(T cell receptor signaling pathway)	afcs:6999(primary-reference)|afcs:55444(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:oIjgqYFjr3oyFSGixSb2jrq03Cc10090	rogid:ugYIdBBXOfQsUJo4CPEuVY1hzm810090	intact-crc:F65E77BCBC94F869|rigid:yHw6JrNlgBKX6i+ICo11wQc+u0w	false	sufficient binding region:464-609	sufficient binding region:265-530	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9D902	uniprotkb:O88351	intact:EBI-309435|uniprotkb:Q3U5Y7|uniprotkb:Q8BTZ2|uniprotkb:Q8VE14|ensembl:ENSMUSP00000126284|ensembl:ENSMUSP00000129834|ensembl:ENSMUSP00000132287	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:t2eb_mouse(display_long)|uniprotkb:Gtf2e2(gene name)|psi-mi:Gtf2e2(display_short)|uniprotkb:Transcription initiation factor IIE subunit beta(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655705	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	dip:DIP-49546N|refseq:NP_001161393.1|refseq:NP_001161394.1|refseq:NP_080860.3|refseq:XP_006509249.1|refseq:XP_006509250.1|refseq:XP_006509251.1|ensembl:ENSMUSG00000031585(gene)|ensembl:ENSMUST00000167264(transcript)|ensembl:ENSMUST00000170705(transcript)|ensembl:ENSMUST00000171010(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005669"(transcription factor TFIID complex)|go:"GO:0005673"(transcription factor TFIIE complex)|go:"GO:0005829"(cytosol)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006367"(transcription initiation from RNA polymerase II promoter)|go:"GO:0016251"(RNA polymerase II general transcription initiation factor activity)|go:"GO:0016607"(nuclear speck)|interpro:IPR003166(Transcription factor TFIIE beta subunit, core)|interpro:IPR016656(Transcription initiation factor IIE, beta subunit)|interpro:IPR036388|interpro:IPR036390|interpro:IPR040501|mint:Q9D902|reactome:R-MMU-674695|reactome:R-MMU-6807505|reactome:R-MMU-73776|reactome:R-MMU-73779|reactome:R-MMU-75953|reactome:R-MMU-76042	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:30508(secondary-ac)	-	-	caution:The prey construct contains 9 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:EODfoQNfoUeYFU67UZPql9HzCB410090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:DD0682D717207069|rigid:j+kh51wbVFCPp0FOLmYUuj6QYHc	false	sufficient binding region:1-292	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P68040	uniprotkb:O88351	intact:EBI-296749|ensembl:ENSMUSP00000020640|uniprotkb:P25388|uniprotkb:P99049|intact:EBI-1183965|uniprotkb:Q3THP0|uniprotkb:Q3THY7|uniprotkb:Q3TKQ0|uniprotkb:Q3TW88|uniprotkb:Q5NCC5|uniprotkb:Q5NCC6|uniprotkb:Q9CSQ0|uniprotkb:Q9ERM6	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:rack1_mouse(display_long)|uniprotkb:p205(gene name synonym)|uniprotkb:Receptor of activated protein kinase C 1(gene name synonym)|uniprotkb:12-3(gene name synonym)|uniprotkb:Gnb2-rs1(gene name synonym)|uniprotkb:Gnb2l1(gene name synonym)|uniprotkb:Guanine nucleotide-binding protein subunit beta-2-like 1(gene name synonym)|uniprotkb:Rack1(gene name)|psi-mi:Rack1(display_short)|uniprotkb:Receptor for activated C kinase(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655716	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:1903076"(regulation of protein localization to plasma membrane)|go:"GO:1903208"(negative regulation of hydrogen peroxide-induced neuron death)|go:"GO:1990630"(IRE1-RACK1-PP2A complex)|go:"GO:2000114"(regulation of establishment of cell polarity)|go:"GO:2000543"(positive regulation of gastrulation)|go:"GO:2001244"(positive regulation of intrinsic apoptotic signaling pathway)|interpro:IPR001680(WD40 repeat)|interpro:IPR015943(WD40/YVTN repeat-like)|interpro:IPR019775|interpro:IPR020472|interpro:IPR036322|mint:P68040|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5626978|go:"GO:0072344"(rescue of stalled ribosome)|ensembl:ENSMUSG00000020372(gene)|ensembl:ENSMUST00000020640(transcript)|go:"GO:0001891"(phagocytic cup)|go:"GO:0001934"(positive regulation of protein phosphorylation)|go:"GO:0005080"(protein kinase C binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006919"(activation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0007049"(cell cycle)|go:"GO:0007369"(gastrulation)|go:"GO:0008104"(protein localization)|go:"GO:0008200"(ion channel inhibitor activity)|go:"GO:0008656"(cysteine-type endopeptidase activator activity involved in apoptotic process)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0015935"(small ribosomal subunit)|go:"GO:0016567"(protein ubiquitination)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0019899"(enzyme binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030178"(negative regulation of Wnt signaling pathway)|go:"GO:0030292"(protein tyrosine kinase inhibitor activity)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030332"(cyclin binding)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030425"(dendrite)|go:"GO:0030496"(midbody)|go:"GO:0030971"(receptor tyrosine kinase binding)|go:"GO:0031334"(positive regulation of protein-containing complex assembly)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0032436"(positive regulation of proteasomal ubiquitin-dependent protein catabolic process)|go:"GO:0006412"(translation)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0038023"(signaling receptor activity)|go:"GO:0042169"(SH2 domain binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0042998"(positive regulation of Golgi to plasma membrane protein transport)|go:"GO:0043005"(neuron projection)|go:"GO:0043022"(ribosome binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0043065"(positive regulation of apoptotic process)|go:"GO:0043204"(perikaryon)|go:"GO:0032880"(regulation of protein localization)|go:"GO:0043473"(pigmentation)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0033137"(negative regulation of peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0044297"(cell body)|go:"GO:0045879"(negative regulation of smoothened signaling pathway)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048511"(rhythmic process)|go:"GO:0050765"(negative regulation of phagocytosis)|go:"GO:0051302"(regulation of cell division)|go:"GO:0051343"(positive regulation of cyclic-nucleotide phosphodiesterase activity)|go:"GO:0051434"(BH3 domain binding)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0051898"(negative regulation of protein kinase B signaling)|go:"GO:0051901"(positive regulation of mitochondrial depolarization)|go:"GO:0071333"(cellular response to glucose stimulus)|go:"GO:0071363"(cellular response to growth factor stimulus)|refseq:NP_032169.1	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:14441(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LXHlhPtxUzHJNncoPteGw2iXsFg10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:7909E66E7EE58BCF|rigid:mBT8Z1z8uu7hetnSaKOmcFuXQWg	false	sufficient binding region:176-317	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9JI13-1	uniprotkb:O88351	intact:EBI-514329|ensembl:ENSMUSP00000087896	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:q9ji13-1(display_long)|uniprotkb:Utp3(gene name)|psi-mi:Utp3(display_short)|uniprotkb:Crl1(gene name synonym)|uniprotkb:Crlz1(gene name synonym)|uniprotkb:Sas10(gene name synonym)|uniprotkb:Charged amino acid-rich leucine zipper 1(gene name synonym)|uniprotkb:Disrupter of silencing SAS10(gene name synonym)|uniprotkb:UTP3 homolog(gene name synonym)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655758	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-475579(sas10_mouse)|ensembl:ENSMUSG00000070697(gene)|ensembl:ENSMUST00000090413(transcript)	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:24221(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:MyKNlQ06NA9Va0veY+CMxvltjXo10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:DC0B98FB84BABA0C|rigid:e0ah71Tx7gm68K+7pCIWIOcsJCg	false	sufficient binding region:109-339	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q91VK1	uniprotkb:O88351	intact:EBI-646202|uniprotkb:Q9D0N4|ensembl:ENSMUSP00000020856	intact:EBI-447960|uniprotkb:Q9R1J6	psi-mi:bzw2_mouse(display_long)|uniprotkb:Bzw2(gene name)|psi-mi:Bzw2(display_short)	psi-mi:ikkb_mouse(display_long)|uniprotkb:I-kappa-B kinase 2(gene name synonym)|uniprotkb:Nuclear factor NF-kappa-B inhibitor kinase beta(gene name synonym)|uniprotkb:Ikbkb(gene name)|psi-mi:Ikbkb(display_short)|uniprotkb:Ikkb(gene name synonym)|uniprotkb:Serine/threonine protein kinase IKBKB(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-655768	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_080116.2|ensembl:ENSMUSG00000020547(gene)|ensembl:ENSMUST00000020856(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0007399"(nervous system development)|go:"GO:0030154"(cell differentiation)|interpro:IPR003307(eIF4-gamma/eIF5/eIF2-epsilon)|interpro:IPR016021(MIF4-like, type 1/2/3)|interpro:IPR043510|interpro:IPR016024(Armadillo-type fold)	refseq:NP_034676.1|dip:DIP-29813N|mint:O88351|go:"GO:0001782"(B cell homeostasis)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007249"(I-kappaB kinase/NF-kappaB signaling)|go:"GO:0007252"(I-kappaB phosphorylation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008384"(IkappaB kinase activity)|go:"GO:0008385"(IkappaB kinase complex)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0010765"(positive regulation of sodium ion transport)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030866"(cortical actin cytoskeleton organization)|go:"GO:0031175"(neuron projection development)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0035509"(negative regulation of myosin-light-chain-phosphatase activity)|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042325"(regulation of phosphorylation)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046982"(protein heterodimerization activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0061847"(response to cholecystokinin)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072659"(protein localization to plasma membrane)|go:"GO:0097110"(scaffold protein binding)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:1901216"(positive regulation of neuron death)|go:"GO:1903140"(regulation of establishment of endothelial barrier)|go:"GO:1903347"(negative regulation of bicellular tight junction assembly)|go:"GO:1990459"(transferrin receptor binding)|go:"GO:2001259"(positive regulation of cation channel activity)|interpro:IPR000719(Protein kinase, core)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR022007|interpro:IPR041185|reactome:R-MMU-1169091|reactome:R-MMU-168638|reactome:R-MMU-1810476|reactome:R-MMU-202424|reactome:R-MMU-209543|reactome:R-MMU-209560|reactome:R-MMU-2871837|reactome:R-MMU-445989|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5607764|reactome:R-MMU-5684264|reactome:R-MMU-9020702|reactome:R-MMU-933542|go:"GO:0005829"(cytosol)|reactome:R-MMU-937039|reactome:R-MMU-937041|reactome:R-MMU-975144	afcs:31405(primary-reference)|afcs:31405(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:JcMA6deOV3O1HtL/V+pBIn59bgU10090	rogid:hpX+Y9AKB4hMKVP4cnfMfvIlPKw10090	intact-crc:96CD3256F07B3665|rigid:FEY7/Kb/61uE4Vgx8DhZojRE1BY	false	sufficient binding region:1-360	sufficient binding region:300-540	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q921C5-1	uniprotkb:Q9JL25	intact:EBI-642995|ensembl:ENSMUSP00000105712	intact:EBI-642400|uniprotkb:Q3TBD1|uniprotkb:Q3TC18|uniprotkb:Q3TD56|uniprotkb:Q3U477|ensembl:ENSMUSP00000140624	psi-mi:q921c5-1(display_long)|uniprotkb:Bicd2(gene name)|psi-mi:Bicd2(display_short)|uniprotkb:Kiaa0699(gene name synonym)	psi-mi:rgs1_mouse(display_long)|uniprotkb:Rgs1(gene name)|psi-mi:Rgs1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650530	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-642984(bicd2_mouse)|ensembl:ENSMUSG00000037933(gene)|ensembl:ENSMUST00000110085(transcript)	refseq:NP_056626.2|reactome:R-MMU-416476|reactome:R-MMU-418594|interpro:IPR036305|ensembl:ENSMUSG00000026358(gene)|ensembl:ENSMUST00000189061(transcript)|go:"GO:0001965"(G-protein alpha-subunit binding)|go:"GO:0005096"(GTPase activator activity)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007165"(signal transduction)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0009617"(response to bacterium)|go:"GO:0009968"(negative regulation of signal transduction)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0043547"(positive regulation of GTPase activity)|go:"GO:0061737"(leukotriene signaling pathway)|interpro:IPR016137(Regulator of G protein signalling superfamily)|interpro:IPR030409	afcs:17628(primary-reference)|afcs:34665(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:dAuH2ow12eQPI8yTZQfH6I4E9LE10090	rogid:tkOVK7JJ2n/5EyhCM6ChMjMWv6410090	intact-crc:D738C7B88AF71D01|rigid:lPa6m+6WMkP5oTwFYbT3zqw6XXc	false	sufficient binding region:26-132	sufficient binding region:14-113	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TNC4	uniprotkb:E9PZQ0	intact:EBI-643009|uniprotkb:Q99LM5|uniprotkb:Q99PC3|ensembl:ENSMUSP00000055254	intact:EBI-642079|uniprotkb:Q60834|uniprotkb:Q61779|uniprotkb:Q61780|uniprotkb:Q62173|uniprotkb:Q62196|uniprotkb:Q62235|uniprotkb:Q78EJ6|uniprotkb:Q7TNG1|uniprotkb:Q80UQ5|uniprotkb:Q80X16|uniprotkb:Q99JF9|ensembl:ENSMUSP00000137123	psi-mi:lc7l2_mouse(display_long)|uniprotkb:CGI-74 homolog(gene name synonym)|uniprotkb:Luc7l2(gene name)|psi-mi:Luc7l2(display_short)	psi-mi:ryr1_mouse(display_long)|uniprotkb:Ryr1(gene name)|psi-mi:Ryr1(display_short)|uniprotkb:Skeletal muscle calcium release channel(gene name synonym)|uniprotkb:Skeletal muscle ryanodine receptor(gene name synonym)|uniprotkb:Skeletal muscle-type ryanodine receptor(gene name synonym)|uniprotkb:Type 1 ryanodine receptor(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-650550	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001164320.1|refseq:NP_619621.2|ensembl:ENSMUSG00000029823(gene)|ensembl:ENSMUST00000057692(transcript)|go:"GO:0003729"(mRNA binding)|go:"GO:0005685"(U1 snRNP)|go:"GO:0006376"(mRNA splice site selection)|go:"GO:0016607"(nuclear speck)|go:"GO:0019899"(enzyme binding)|go:"GO:0071004"(U2-type prespliceosome)|interpro:IPR004882(LUC7 related)|mint:Q7TNC4	refseq:NP_033135.2|interpro:IPR009460(Ryanodine Receptor TM 4-6)|interpro:IPR011992(EF-Hand type)|interpro:IPR013320(Concanavalin A-like lectin/glucanase, subgroup)|interpro:IPR013333(Ryanodine receptor, N-terminal)|interpro:IPR013662(RyR and IP3R Homology associated)|interpro:IPR014821(Inositol 1,4,5-trisphosphate/ryanodine receptor)|interpro:IPR016093(MIR motif)|interpro:IPR033215|interpro:IPR035761|interpro:IPR035762|interpro:IPR035764|interpro:IPR035910|interpro:IPR036300|interpro:IPR043136|reactome:R-MMU-2672351|reactome:R-MMU-5578775|interpro:IPR005821(Ion transport)|ensembl:ENSMUSG00000030592(gene)|ensembl:ENSMUST00000179893(transcript)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002020"(protease binding)|go:"GO:0003151"(outflow tract morphogenesis)|go:"GO:0005219"(ryanodine-sensitive calcium-release channel activity)|go:"GO:0005245"(voltage-gated calcium channel activity)|go:"GO:0005262"(calcium channel activity)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005790"(smooth endoplasmic reticulum)|go:"GO:0005886"(plasma membrane)|go:"GO:0005938"(cell cortex)|go:"GO:0006816"(calcium ion transport)|go:"GO:0006936"(muscle contraction)|go:"GO:0006937"(regulation of muscle contraction)|go:"GO:0014802"(terminal cisterna)|go:"GO:0014808"(release of sequestered calcium ion into cytosol by sarcoplasmic reticulum)|go:"GO:0016020"(membrane)|go:"GO:0016529"(sarcoplasmic reticulum)|go:"GO:0019899"(enzyme binding)|go:"GO:0030018"(Z disc)|go:"GO:0030314"(junctional membrane complex)|go:"GO:0030315"(T-tubule)|go:"GO:0005516"(calmodulin binding)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0031000"(response to caffeine)|go:"GO:0031234"(extrinsic component of cytoplasmic side of plasma membrane)|go:"GO:0031301"(integral component of organelle membrane)|go:"GO:0031674"(I band)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033017"(sarcoplasmic reticulum membrane)|go:"GO:0034704"(calcium channel complex)|go:"GO:0042383"(sarcolemma)|go:"GO:0043588"(skin development)|go:"GO:0043931"(ossification involved in bone maturation)|go:"GO:0048741"(skeletal muscle fiber development)|go:"GO:0048763"(calcium-induced calcium release activity)|go:"GO:0051209"(release of sequestered calcium ion into cytosol)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0051480"(regulation of cytosolic calcium ion concentration)|go:"GO:0070296"(sarcoplasmic reticulum calcium ion transport)|go:"GO:0071277"(cellular response to calcium ion)|go:"GO:0071313"(cellular response to caffeine)|go:"GO:0071318"(cellular response to ATP)|go:"GO:1990425"(ryanodine receptor complex)|interpro:IPR000699(Intracellular calcium-release channel)|interpro:IPR001870("B302 (SPRY)-like")|interpro:IPR003032(Ryanodine receptor Ryr)|interpro:IPR003877(SPla/RYanodine receptor SPRY)|dip:DIP-29705N	afcs:23471(primary-reference)|afcs:34661(secondary-ac)	-	caution:This sequence has been withdrawn from Uniprot.|crc64:D15D2E764B445573	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4x7JD0FyuuhCrHahqU96S6UyD1o10090	rogid:7pqK+A18JdTdARXDh+VTkS0z73c10090	intact-crc:19871ABAE18F37BB|rigid:CpozIbClrdiBsFP7+yYutUMK5j8	false	sufficient binding region:267-342	sufficient binding region:4917-5035	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYB1	uniprotkb:P70181	intact:EBI-645175|uniprotkb:Q8BMG5|ensembl:ENSMUSP00000041453	intact:EBI-645167|uniprotkb:O70335|uniprotkb:Q8JZY6|ensembl:ENSMUSP00000025800	psi-mi:clic4_mouse(display_long)|uniprotkb:Clic4(gene name)|psi-mi:Clic4(display_short)	psi-mi:pi51b_mouse(display_long)|uniprotkb:Pip5k1b(gene name)|psi-mi:Pip5k1b(display_short)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I beta(gene name synonym)|uniprotkb:68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653897	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038913.1|ensembl:ENSMUSG00000037242(gene)|ensembl:ENSMUST00000037099(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006821"(chloride transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002946(Intracellular chloride channel)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR030257|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:Q9QYB1	refseq:NP_032872.1|refseq:XP_006526826.1|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|reactome:R-MMU-1660499|reactome:R-MMU-201688|reactome:R-MMU-6811558|ensembl:ENSMUSG00000024867(gene)|ensembl:ENSMUST00000025800(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)	afcs:15015(primary-reference)|afcs:17522(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ghFdQmcUo1BuprnYT0mQRKnjgcw10090	rogid:heOUYCsDnkVH7SY/9uX3eoH0d+k10090	intact-crc:C8E20F5900A8AF8A|rigid:hMkRHw6cBF2ee14irdYJVjx39r4	false	sufficient binding region:66-253	sufficient binding region:350-500	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QYB1	uniprotkb:P70181	intact:EBI-645175|uniprotkb:Q8BMG5|ensembl:ENSMUSP00000041453	intact:EBI-645167|uniprotkb:O70335|uniprotkb:Q8JZY6|ensembl:ENSMUSP00000025800	psi-mi:clic4_mouse(display_long)|uniprotkb:Clic4(gene name)|psi-mi:Clic4(display_short)	psi-mi:pi51b_mouse(display_long)|uniprotkb:Pip5k1b(gene name)|psi-mi:Pip5k1b(display_short)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I alpha(gene name synonym)|uniprotkb:Phosphatidylinositol 4-phosphate 5-kinase type I beta(gene name synonym)|uniprotkb:68 kDa type I phosphatidylinositol 4-phosphate 5-kinase beta(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-653928	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_038913.1|ensembl:ENSMUSG00000037242(gene)|ensembl:ENSMUST00000037099(transcript)|go:"GO:0001525"(angiogenesis)|go:"GO:0001886"(endothelial cell morphogenesis)|go:"GO:0005244"(voltage-gated ion channel activity)|go:"GO:0005254"(chloride channel activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005813"(centrosome)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005911"(cell-cell junction)|go:"GO:0006821"(chloride transport)|go:"GO:0007035"(vacuolar acidification)|go:"GO:0009566"(fertilization)|go:"GO:0009986"(cell surface)|go:"GO:0016363"(nuclear matrix)|go:"GO:0030216"(keratinocyte differentiation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0030496"(midbody)|go:"GO:0030659"(cytoplasmic vesicle membrane)|go:"GO:0034707"(chloride channel complex)|go:"GO:0034765"(regulation of ion transmembrane transport)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045177"(apical part of cell)|go:"GO:0048471"(perinuclear region of cytoplasm)|go:"GO:0048754"(branching morphogenesis of an epithelial tube)|go:"GO:0061299"(retina vasculature morphogenesis in camera-type eye)|go:"GO:0071277"(cellular response to calcium ion)|interpro:IPR002946(Intracellular chloride channel)|interpro:IPR010987(Glutathione S-transferase, C-terminal-like)|interpro:IPR030257|interpro:IPR036249|interpro:IPR036282|interpro:IPR040079|mint:Q9QYB1	refseq:NP_032872.1|refseq:XP_006526826.1|interpro:IPR002498(Phosphatidylinositol-4-phosphate 5-kinase, core)|interpro:IPR023610|interpro:IPR027484|reactome:R-MMU-1660499|reactome:R-MMU-201688|reactome:R-MMU-6811558|ensembl:ENSMUSG00000024867(gene)|ensembl:ENSMUST00000025800(transcript)|go:"GO:0001931"(uropod)|go:"GO:0005524"(ATP binding)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006661"(phosphatidylinositol biosynthetic process)|go:"GO:0012505"(endomembrane system)|go:"GO:0016308"(1-phosphatidylinositol-4-phosphate 5-kinase activity)|go:"GO:0046488"(phosphatidylinositol metabolic process)	afcs:15015(primary-reference)|afcs:17522(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:ghFdQmcUo1BuprnYT0mQRKnjgcw10090	rogid:heOUYCsDnkVH7SY/9uX3eoH0d+k10090	intact-crc:931FC9486C5DB996|rigid:hMkRHw6cBF2ee14irdYJVjx39r4	false	sufficient binding region:113-253	sufficient binding region:350-500	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P51807	uniprotkb:Q9Z1T1	intact:EBI-642797|uniprotkb:Q5M8S6|ensembl:ENSMUSP00000137171|ensembl:ENSMUSP00000135978|ensembl:ENSMUSP00000090644|ensembl:ENSMUSP00000127990	intact:EBI-643061|uniprotkb:E9QQ08|uniprotkb:Q91YR4|ensembl:ENSMUSP00000022196	psi-mi:dylt1_mouse(display_long)|uniprotkb:T-complex testis-specific protein 1(gene name synonym)|uniprotkb:TCTEX-1(gene name synonym)|uniprotkb:Tctex1(gene name synonym)|uniprotkb:Tctex-1(gene name synonym)|uniprotkb:Dynlt1(gene name)|psi-mi:Dynlt1(display_short)|uniprotkb:Activator of G-protein signaling 2(gene name synonym)|uniprotkb:Tctel1(gene name synonym)	psi-mi:ap3b1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-3 subunit beta-1(gene name synonym)|uniprotkb:Beta-3A-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 3 beta-1 large chain(gene name synonym)|uniprotkb:Ap3b1(gene name)|psi-mi:Ap3b1(display_short)|uniprotkb:Adaptor-related protein complex 3 subunit beta-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654442	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001160099.1|refseq:NP_001160101.1|refseq:NP_001160102.1|refseq:NP_033368.1|ensembl:ENSMUST00000092966(transcript)|ensembl:ENSMUST00000169415(transcript)|ensembl:ENSMUST00000179554(transcript)|ensembl:ENSMUST00000179569(transcript)|go:"GO:0000132"(establishment of mitotic spindle orientation)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005819"(spindle)|go:"GO:0005868"(cytoplasmic dynein complex)|go:"GO:0005881"(cytoplasmic microtubule)|go:"GO:0008022"(protein C-terminus binding)|go:"GO:0008277"(regulation of G protein-coupled receptor signaling pathway)|go:"GO:0010976"(positive regulation of neuron projection development)|go:"GO:0030027"(lamellipodium)|go:"GO:0030426"(growth cone)|go:"GO:0031681"(G-protein beta-subunit binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043025"(neuronal cell body)|go:"GO:0044295"(axonal growth cone)|go:"GO:0044297"(cell body)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051301"(cell division)|go:"GO:0070373"(negative regulation of ERK1 and ERK2 cascade)|go:"GO:0099503"(secretory vesicle)|interpro:IPR005334(Tctex-1)|interpro:IPR038586|mint:P51807|rcsb pdb:5WI4|reactome:R-MMU-6798695|go:"GO:0030742"(GTP-dependent protein binding)|ensembl:ENSMUSG00000000579(gene)|ensembl:ENSMUSG00000092074(gene)|ensembl:ENSMUSG00000095677(gene)|ensembl:ENSMUSG00000096255(gene)|refseq:XP_017172676.1	refseq:NP_033810.2|ensembl:ENSMUSG00000021686(gene)|ensembl:ENSMUST00000022196(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003016"(respiratory system process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006954"(inflammatory response)|go:"GO:0007040"(lysosome organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030324"(lung development)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032438"(melanosome organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0043473"(pigmentation)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0090152"(establishment of protein localization to mitochondrial membrane involved in mitochondrial fission)|go:"GO:0098773"(skin epidermis development)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026739|interpro:IPR026740|interpro:IPR029390|interpro:IPR029394|mint:Q9Z1T1|reactome:R-MMU-432722|dip:DIP-49018N	afcs:9401(secondary-ac)|afcs:15675(primary-reference)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:fn6QN4J3aA++93iJwG3rFDjPBvM10090	rogid:Xtcoo5Kk0ZYpVbr+WEBfVxidkVU10090	intact-crc:C3B7192A63CDB350|rigid:BpMxmq/dwYpXuGnEYxfcU84RTTQ	false	sufficient binding region:1-113	sufficient binding region:1-160	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54724	uniprotkb:Q9Z1T1	intact:EBI-645496|uniprotkb:Q2TAW6|ensembl:ENSMUSP00000058321	intact:EBI-643061|uniprotkb:E9QQ08|uniprotkb:Q91YR4|ensembl:ENSMUSP00000022196	psi-mi:cavn1_mouse(display_long)|uniprotkb:Cavin1(gene name)|psi-mi:Cavin1(display_short)|uniprotkb:Cav-p60(gene name synonym)|uniprotkb:Cavin-1(gene name synonym)|uniprotkb:Polymerase I and transcript release factor(gene name synonym)|uniprotkb:Ptrf(gene name synonym)	psi-mi:ap3b1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-3 subunit beta-1(gene name synonym)|uniprotkb:Beta-3A-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 3 beta-1 large chain(gene name synonym)|uniprotkb:Ap3b1(gene name)|psi-mi:Ap3b1(display_short)|uniprotkb:Adaptor-related protein complex 3 subunit beta-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654463	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033012.1|dip:DIP-40506N|ensembl:ENSMUSG00000004044(gene)|ensembl:ENSMUST00000060792(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006363"(termination of RNA polymerase I transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009306"(protein secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR026752|interpro:IPR033297|mint:O54724|rcsb pdb:4QKV|reactome:R-MMU-73863|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106	refseq:NP_033810.2|ensembl:ENSMUSG00000021686(gene)|ensembl:ENSMUST00000022196(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003016"(respiratory system process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006954"(inflammatory response)|go:"GO:0007040"(lysosome organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030324"(lung development)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032438"(melanosome organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0043473"(pigmentation)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0090152"(establishment of protein localization to mitochondrial membrane involved in mitochondrial fission)|go:"GO:0098773"(skin epidermis development)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026739|interpro:IPR026740|interpro:IPR029390|interpro:IPR029394|mint:Q9Z1T1|reactome:R-MMU-432722|dip:DIP-49018N	afcs:15675(primary-reference)|afcs:15128(secondary-ac)	-	-	caution:The prey construct contains 32 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hPJHFyrpyl5yz+7Brojuu3W2bEA10090	rogid:Xtcoo5Kk0ZYpVbr+WEBfVxidkVU10090	intact-crc:8828FD85A909A7DB|rigid:ALJzPC4+FInTQdDtEDrQKPZ/3j8	false	sufficient binding region:1-186	sufficient binding region:634-911	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O54724	uniprotkb:Q9Z1T1	intact:EBI-645496|uniprotkb:Q2TAW6|ensembl:ENSMUSP00000058321	intact:EBI-643061|uniprotkb:E9QQ08|uniprotkb:Q91YR4|ensembl:ENSMUSP00000022196	psi-mi:cavn1_mouse(display_long)|uniprotkb:Cavin1(gene name)|psi-mi:Cavin1(display_short)|uniprotkb:Cav-p60(gene name synonym)|uniprotkb:Cavin-1(gene name synonym)|uniprotkb:Polymerase I and transcript release factor(gene name synonym)|uniprotkb:Ptrf(gene name synonym)	psi-mi:ap3b1_mouse(display_long)|uniprotkb:Adaptor protein complex AP-3 subunit beta-1(gene name synonym)|uniprotkb:Beta-3A-adaptin(gene name synonym)|uniprotkb:Clathrin assembly protein complex 3 beta-1 large chain(gene name synonym)|uniprotkb:Ap3b1(gene name)|psi-mi:Ap3b1(display_short)|uniprotkb:Adaptor-related protein complex 3 subunit beta-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654475	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_033012.1|dip:DIP-40506N|ensembl:ENSMUSG00000004044(gene)|ensembl:ENSMUST00000060792(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0006361"(transcription initiation from RNA polymerase I promoter)|go:"GO:0006363"(termination of RNA polymerase I transcription)|go:"GO:0009303"(rRNA transcription)|go:"GO:0009306"(protein secretion)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042134"(rRNA primary transcript binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:2000147"(positive regulation of cell motility)|interpro:IPR026752|interpro:IPR033297|mint:O54724|rcsb pdb:4QKV|reactome:R-MMU-73863|reactome:R-MMU-8980692|reactome:R-MMU-9013026|reactome:R-MMU-9013106	refseq:NP_033810.2|ensembl:ENSMUSG00000021686(gene)|ensembl:ENSMUST00000022196(transcript)|go:"GO:0000902"(cell morphogenesis)|go:"GO:0002224"(toll-like receptor signaling pathway)|go:"GO:0002244"(hematopoietic progenitor cell differentiation)|go:"GO:0003016"(respiratory system process)|go:"GO:0005739"(mitochondrion)|go:"GO:0005802"(trans-Golgi network)|go:"GO:0006464"(cellular protein modification process)|go:"GO:0006622"(protein targeting to lysosome)|go:"GO:0006829"(zinc ion transport)|go:"GO:0006882"(cellular zinc ion homeostasis)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006954"(inflammatory response)|go:"GO:0007040"(lysosome organization)|go:"GO:0007283"(spermatogenesis)|go:"GO:0007338"(single fertilization)|go:"GO:0007596"(blood coagulation)|go:"GO:0008089"(anterograde axonal transport)|go:"GO:0016182"(synaptic vesicle budding from endosome)|go:"GO:0016192"(vesicle-mediated transport)|go:"GO:0019882"(antigen processing and presentation)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0030123"(AP-3 adaptor complex)|go:"GO:0030131"(clathrin adaptor complex)|go:"GO:0030324"(lung development)|go:"GO:0030665"(clathrin-coated vesicle membrane)|go:"GO:0030742"(GTP-dependent protein binding)|go:"GO:0030851"(granulocyte differentiation)|go:"GO:0032438"(melanosome organization)|go:"GO:0034394"(protein localization to cell surface)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0043473"(pigmentation)|go:"GO:0045202"(synapse)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0048007"(antigen processing and presentation, exogenous lipid antigen via MHC class Ib)|go:"GO:0048490"(anterograde synaptic vesicle transport)|go:"GO:0048872"(homeostasis of number of cells)|go:"GO:0050790"(regulation of catalytic activity)|go:"GO:0051138"(positive regulation of NK T cell differentiation)|go:"GO:0060155"(platelet dense granule organization)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0061024"(membrane organization)|go:"GO:0090152"(establishment of protein localization to mitochondrial membrane involved in mitochondrial fission)|go:"GO:0098773"(skin epidermis development)|go:"GO:1904115"(axon cytoplasm)|interpro:IPR002553(Clathrin/coatomer adaptor, adaptin-like, N-terminal)|interpro:IPR015151(Clathrin adaptor, beta-adaptin, appendage, C-terminal subdomain)|interpro:IPR016024(Armadillo-type fold)|interpro:IPR026739|interpro:IPR026740|interpro:IPR029390|interpro:IPR029394|mint:Q9Z1T1|reactome:R-MMU-432722|dip:DIP-49018N	afcs:15675(primary-reference)|afcs:15128(secondary-ac)	-	-	caution:The prey construct contains 16 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:hPJHFyrpyl5yz+7Brojuu3W2bEA10090	rogid:Xtcoo5Kk0ZYpVbr+WEBfVxidkVU10090	intact-crc:F683322045173BF6|rigid:ALJzPC4+FInTQdDtEDrQKPZ/3j8	false	sufficient binding region:1-179	sufficient binding region:634-911	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9R1C7-1	uniprotkb:Q8CBW3	intact:EBI-645566|ensembl:ENSMUSP00000159339	intact:EBI-375511|uniprotkb:Q3U8V0|uniprotkb:Q60747|uniprotkb:Q91ZM5|uniprotkb:Q923I9|uniprotkb:Q99KH4|ensembl:ENSMUSP00000118491	psi-mi:q9r1c7-1(display_long)|uniprotkb:Prpf40a(gene name)|psi-mi:Prpf40a(display_short)|uniprotkb:Fbp11(gene name synonym)|uniprotkb:Fnbp3(gene name synonym)|uniprotkb:Formin-binding protein 11(gene name synonym)|uniprotkb:Formin-binding protein 3(gene name synonym)	psi-mi:abi1_mouse(display_long)|uniprotkb:Abi1(gene name)|psi-mi:Abi1(display_short)|uniprotkb:Ssh3bp1(gene name synonym)|uniprotkb:Abelson interactor 1(gene name synonym)|uniprotkb:Spectrin SH3 domain-binding protein 1(gene name synonym)|uniprotkb:Eps8 SH3 domain-binding protein(gene name synonym)|uniprotkb:e3B1(gene name synonym)|uniprotkb:Ablphilin-1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654528	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645554(fnbp3_mouse)|ensembl:ENSMUSG00000061136(gene)|ensembl:ENSMUST00000239398(transcript)	refseq:NP_031406.2|refseq:NP_001070658.1|refseq:NP_001070660.1|refseq:NP_001070661.1|ensembl:ENSMUSG00000058835(gene)|ensembl:ENSMUST00000123948(transcript)|go:"GO:0001756"(somitogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005856"(cytoskeleton)|go:"GO:0008154"(actin polymerization or depolymerization)|go:"GO:0014069"(postsynaptic density)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0018108"(peptidyl-tyrosine phosphorylation)|go:"GO:0030027"(lamellipodium)|go:"GO:0030296"(protein tyrosine kinase activator activity)|go:"GO:0030426"(growth cone)|go:"GO:0031209"(SCAR complex)|go:"GO:0031252"(cell leading edge)|go:"GO:0032433"(filopodium tip)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0035855"(megakaryocyte development)|go:"GO:0043005"(neuron projection)|go:"GO:0048813"(dendrite morphogenesis)|go:"GO:0072673"(lamellipodium morphogenesis)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR001452(Src homology-3)|interpro:IPR012849(Abl-interactor, homeo-domain homologous region)|interpro:IPR028456|interpro:IPR028457|interpro:IPR035725|interpro:IPR036028|mint:Q8CBW3|reactome:R-MMU-2029482|reactome:R-MMU-4420097|reactome:R-MMU-5663213|reactome:R-MMU-9013149|reactome:R-MMU-9013404|reactome:R-MMU-9013423|dip:DIP-29534N	afcs:33872(primary-reference)|afcs:17951(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:urpZDf+jd9lovL7obd2Y+a/lBCE10090	rogid:mDXRmY9uUy6POYZDWeVlwDPxAIs10090	intact-crc:BDBBC4F47D6866E2|rigid:m15au6ZxGAnvLsppMsrczAhUFMo	false	sufficient binding region:113-265	sufficient binding region:306-417	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O88974	uniprotkb:P70392	intact:EBI-79658|uniprotkb:Q6AXH8|uniprotkb:Q78N64|uniprotkb:Q78N65|uniprotkb:Q80U84|uniprotkb:Q8BTV6|uniprotkb:Q8CIX7|uniprotkb:Q922K1	intact:EBI-645472|uniprotkb:Q3TYN3|uniprotkb:Q9QX51|ensembl:ENSMUSP00000116892	psi-mi:setb1_mouse(display_long)|uniprotkb:Setdb1(gene name)|psi-mi:Setdb1(display_short)|uniprotkb:Eset(gene name synonym)|uniprotkb:Kiaa0067(gene name synonym)|uniprotkb:SET domain bifurcated 1(gene name synonym)|uniprotkb:ERG-associated protein with SET domain(gene name synonym)	psi-mi:rgrf2_mouse(display_long)|uniprotkb:Grf2(gene name synonym)|uniprotkb:Ras guanine nucleotide exchange factor 2(gene name synonym)|uniprotkb:Rasgrf2(gene name)|psi-mi:Rasgrf2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654538	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001833"(inner cell mass cell proliferation)|go:"GO:0003677"(DNA binding)|go:"GO:0003682"(chromatin binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005694"(chromosome)|go:"GO:0005737"(cytoplasm)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0008270"(zinc ion binding)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0018024"(histone-lysine N-methyltransferase activity)|go:"GO:0036124"(histone H3-K9 trimethylation)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045869"(negative regulation of single stranded viral RNA replication via double stranded DNA intermediate)|go:"GO:0046974"("histone methyltransferase activity (H3-K9 specific)")|go:"GO:0051567"(histone H3-K9 methylation)|go:"GO:0060348"(bone development)|go:"GO:0070828"(heterochromatin organization)|go:"GO:0090309"(positive regulation of DNA methylation-dependent heterochromatin assembly)|go:"GO:1990841"(promoter-specific chromatin binding)|interpro:IPR016177(DNA-binding, integrase-type)|interpro:IPR001739(Methyl-CpG DNA binding)|interpro:IPR003616(Post-SET zinc-binding region)|interpro:IPR007728(Pre-SET zinc-binding region)|interpro:IPR001214(SET)|interpro:IPR040880|interpro:IPR041291|interpro:IPR041292|reactome:R-MMU-3214841|interpro:IPR002999(Tudor)|interpro:IPR025796	refseq:NP_033053.2|ensembl:ENSMUSG00000021708(gene)|ensembl:ENSMUST00000151408(transcript)|go:"GO:0005085"(guanyl-nucleotide exchange factor activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005783"(endoplasmic reticulum)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0007264"(small GTPase mediated signal transduction)|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:0035023"(regulation of Rho protein signal transduction)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:2000310"(regulation of NMDA receptor activity)|interpro:IPR000048(IQ calmodulin-binding region)|interpro:IPR000219("Dbl homology (DH) domain")|interpro:IPR000651(Guanine nucleotide exchange factor for Ras-like GTPases, N-terminal)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR001895(Guanine-nucleotide dissociation stimulator CDC25)|interpro:IPR008937(Ras guanine nucleotide exchange factor)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR019804|interpro:IPR023578|interpro:IPR030744|interpro:IPR035899|interpro:IPR036964|reactome:R-MMU-193648|reactome:R-MMU-416482|reactome:R-MMU-5673001|reactome:R-MMU-8980692|reactome:R-MMU-9013148|reactome:R-MMU-9013149	afcs:15164(primary-reference)|afcs:18020(secondary-ac)	-	-	caution:The prey construct contains 30 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:wopdjnSA/Ng9vtDW1AdBfPicNdo10090	rogid:ot1s64p6SCwAmdb7PBYjuO4mLKk10090	intact-crc:B0D874D62C6C8884|rigid:MUUTjmkve83EEib9GvT1OCfJeZM	false	sufficient binding region:1-211	sufficient binding region:150-445	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8C0D7-2	uniprotkb:P12849	intact:EBI-645612|ensembl:ENSMUSP00000032480	intact:EBI-645585|ensembl:ENSMUSP00000026973|ensembl:ENSMUSP00000106515	psi-mi:q8c0d7-2(display_long)|uniprotkb:Ing4(gene name)|psi-mi:Ing4(display_short)|uniprotkb:p29ING4(gene name synonym)|uniprotkb:mINGh-M(isoform synonym)	psi-mi:kap1_mouse(display_long)|uniprotkb:Prkar1b(gene name)|psi-mi:Prkar1b(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-654559	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645598(ing4_mouse)|ensembl:ENSMUSG00000030330(gene)|ensembl:ENSMUST00000032480(transcript)	refseq:NP_032949.3|refseq:XP_006504723.1|refseq:XP_006504724.1|refseq:XP_006504726.1|refseq:NP_001240819.1|refseq:XP_017176208.1|go:"GO:0010738"(regulation of protein kinase A signaling)|go:"GO:0030552"(cAMP binding)|go:"GO:0034236"(protein kinase A catalytic subunit binding)|go:"GO:0043949"(regulation of cAMP-mediated signaling)|go:"GO:0045202"(synapse)|go:"GO:0045859"(regulation of protein kinase activity)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098686"(hippocampal mossy fiber to CA3 synapse)|go:"GO:0098693"(regulation of synaptic vesicle cycle)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:2000480"(negative regulation of cAMP-dependent protein kinase activity)|interpro:IPR000595(Cyclic nucleotide-binding)|interpro:IPR003117(cAMP-dependent protein kinase, regulatory subunit, type I/II alpha/beta)|interpro:IPR012198(cAMP-dependent protein kinase regulatory subunit)|interpro:IPR014710(RmlC-like jelly roll fold)|go:"GO:0009887"(animal organ morphogenesis)|interpro:IPR018488|interpro:IPR018490|interpro:IPR042818|mint:P12849|reactome:R-MMU-163615|reactome:R-MMU-164378|reactome:R-MMU-180024|reactome:R-MMU-432040|reactome:R-MMU-442720|reactome:R-MMU-5610787|reactome:R-MMU-983231|ensembl:ENSMUSG00000025855(gene)|ensembl:ENSMUST00000026973(transcript)|ensembl:ENSMUST00000110890(transcript)|go:"GO:0004862"(cAMP-dependent protein kinase inhibitor activity)|go:"GO:0005737"(cytoplasm)|go:"GO:0005771"(multivesicular body)|go:"GO:0005886"(plasma membrane)|go:"GO:0005952"(cAMP-dependent protein kinase complex)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0007611"(learning or memory)|go:"GO:0008603"(cAMP-dependent protein kinase regulator activity)	afcs:15079(primary-reference)|afcs:53140(secondary-ac)	isoform-comment:May be due to a competing donor splice site.	-	caution:The prey construct contains 2 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:zv972KDJy09rLn9CTrSNKrK/zDs10090	rogid:w65y6gB5uVAjfKjbAidQPpWtgAo10090	intact-crc:89598204553FA740|rigid:DtSmFFARMqn+VMwwf48UOqij9s0	false	sufficient binding region:1-247	sufficient binding region:70-259	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q09163	uniprotkb:Q62406-1	intact:EBI-646470|uniprotkb:Q07645|uniprotkb:Q62208	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:dlk1_mouse(display_long)|uniprotkb:Preadipocyte factor 1(gene name synonym)|uniprotkb:Adipocyte differentiation inhibitor protein(gene name synonym)|uniprotkb:Dlk1(gene name)|psi-mi:Dlk1(display_short)|uniprotkb:Dlk(gene name synonym)|uniprotkb:Pref1(gene name synonym)|uniprotkb:Scp-1(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656248	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034182.2|dip:DIP-6010N|go:"GO:0001503"(ossification)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001819"(positive regulation of cytokine production)|go:"GO:0005509"(calcium ion binding)|go:"GO:0005615"(extracellular space)|go:"GO:0005737"(cytoplasm)|go:"GO:0005886"(plasma membrane)|go:"GO:0009791"(post-embryonic development)|go:"GO:0009897"(external side of plasma membrane)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0030154"(cell differentiation)|go:"GO:0030279"(negative regulation of ossification)|go:"GO:0030282"(bone mineralization)|go:"GO:0035264"(multicellular organism growth)|go:"GO:0045599"(negative regulation of fat cell differentiation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045672"(positive regulation of osteoclast differentiation)|go:"GO:0045746"(negative regulation of Notch signaling pathway)|go:"GO:0045780"(positive regulation of bone resorption)|go:"GO:0046850"(regulation of bone remodeling)|go:"GO:0048706"(embryonic skeletal system development)|go:"GO:1905563"(negative regulation of vascular endothelial cell proliferation)|interpro:IPR000152(Aspartic acid and asparagine hydroxylation site)|interpro:IPR000742(EGF-like, type 3)|interpro:IPR001881(EGF-like calcium-binding)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:12588(secondary-ac)	-	-	caution:The prey construct contains 1 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LlVT6V8bZp5yYAxg9litO6uvziw10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:A045FDA9604EE6DF|rigid:LEw5VlJWMwW8IaHj7Yj2Fgxghhc	false	sufficient binding region:1-173	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37889-1	uniprotkb:Q62406-1	intact:EBI-645953|ensembl:ENSMUSP00000048334	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656258	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:ACA5B35305556670|rigid:/vAILo4zesG8yEikADQz1kvVntI	false	sufficient binding region:961-1221	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37889-1	uniprotkb:Q62406-1	intact:EBI-645953|ensembl:ENSMUSP00000048334	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656278	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:03F0BD8F270D7433|rigid:/vAILo4zesG8yEikADQz1kvVntI	false	sufficient binding region:1004-1221	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37889-1	uniprotkb:Q62406-1	intact:EBI-645953|ensembl:ENSMUSP00000048334	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656298	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:962F4BB539E8092F|rigid:/vAILo4zesG8yEikADQz1kvVntI	false	sufficient binding region:1035-1221	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37889-1	uniprotkb:Q62406-1	intact:EBI-645953|ensembl:ENSMUSP00000048334	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656328	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:1AB24B85FB419205|rigid:/vAILo4zesG8yEikADQz1kvVntI	false	sufficient binding region:1071-1221	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37889-1	uniprotkb:Q62406-1	intact:EBI-645953|ensembl:ENSMUSP00000048334	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656338	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:081265579E311B6A|rigid:/vAILo4zesG8yEikADQz1kvVntI	false	sufficient binding region:1084-1221	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P37889-1	uniprotkb:Q62406-1	intact:EBI-645953|ensembl:ENSMUSP00000048334	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:p37889-1(display_long)|uniprotkb:Fbln2(gene name)|psi-mi:Fbln2(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656348	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	intact:EBI-645941(fbln2_mouse)|ensembl:ENSMUST00000041544(transcript)|ensembl:ENSMUSG00000064080(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:14306(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4kvzu0U6xFByoudTl6Pq4mBF/dc10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:F335255BAE9B7DA0|rigid:/vAILo4zesG8yEikADQz1kvVntI	false	sufficient binding region:1095-1221	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3THG9	uniprotkb:Q62406-1	intact:EBI-646572|uniprotkb:Q3UWH8|uniprotkb:Q8BVJ6|uniprotkb:Q99JS9|ensembl:ENSMUSP00000067912	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:aasd1_mouse(display_long)|uniprotkb:Aarsd1(gene name)|psi-mi:Aarsd1(display_short)|uniprotkb:Alax(gene name synonym)|uniprotkb:Alanyl-tRNA deacylase alaX(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656398	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659078.1|ensembl:ENSMUST00000070395(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR018165|mint:Q3THG9|ensembl:ENSMUSG00000075528(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:55462(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LOhCc9VYhW33LcVAjKY7U5mBxG010090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:B9CA0FF228B68D7E|rigid:TTlbLetSO6InReymD4LD/BGv5zE	false	sufficient binding region:88-412	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q3THG9	uniprotkb:Q62406-1	intact:EBI-646572|uniprotkb:Q3UWH8|uniprotkb:Q8BVJ6|uniprotkb:Q99JS9|ensembl:ENSMUSP00000067912	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:aasd1_mouse(display_long)|uniprotkb:Aarsd1(gene name)|psi-mi:Aarsd1(display_short)|uniprotkb:Alax(gene name synonym)|uniprotkb:Alanyl-tRNA deacylase alaX(gene name synonym)|uniprotkb:Alanyl-tRNA synthetase domain-containing protein 1(gene name synonym)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-656428	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_659078.1|ensembl:ENSMUST00000070395(transcript)|go:"GO:0002161"(aminoacyl-tRNA editing activity)|go:"GO:0002196"("Ser-tRNA(Ala) hydrolase activity")|go:"GO:0003676"(nucleic acid binding)|go:"GO:0004813"(alanine-tRNA ligase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006419"(alanyl-tRNA aminoacylation)|go:"GO:0006450"(regulation of translational fidelity)|go:"GO:0046872"(metal ion binding)|interpro:IPR009000(Translation elongation and initiation factors/Ribosomal, beta-barrel)|interpro:IPR012947(Threonyl/alanyl tRNA synthetase, SAD)|interpro:IPR018163|interpro:IPR018165|mint:Q3THG9|ensembl:ENSMUSG00000075528(gene)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:55462(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:LOhCc9VYhW33LcVAjKY7U5mBxG010090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:A7AC00EE7CFB1005|rigid:TTlbLetSO6InReymD4LD/BGv5zE	false	sufficient binding region:102-253	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q99KX1	uniprotkb:P42227	intact:EBI-646781|ensembl:ENSMUSP00000032214|ensembl:ENSMUSP00000135920	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:mlf2_mouse(display_long)|uniprotkb:Myelodysplasia-myeloid leukemia factor 2(gene name synonym)|uniprotkb:Mlf2(gene name)|psi-mi:Mlf2(display_short)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657414	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001163812.1|refseq:NP_663360.1|ensembl:ENSMUSG00000030120(gene)|ensembl:ENSMUST00000032214(transcript)|ensembl:ENSMUST00000180095(transcript)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0006355"(regulation of transcription, DNA-templated)|interpro:IPR019376|mint:Q99KX1	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:58076(secondary-ac)	-	-	caution:The prey construct contains 1 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:/TTRBTfO7JkzWbvIALSR+GeA5aU10090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:D42613C70DA0633D|rigid:adSjUDcCmlHQs2LsnAT+LC6M9/8	false	sufficient binding region:1-201	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P42227	uniprotkb:P23927	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	intact:EBI-299046|ensembl:ENSMUSP00000034562|ensembl:ENSMUSP00000149759|ensembl:ENSMUSP00000149803|ensembl:ENSMUSP00000150669|uniprotkb:Q64325	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:cryab_mouse(display_long)|uniprotkb:Cryab(gene name)|psi-mi:Cryab(display_short)|uniprotkb:Crya2(gene name synonym)|uniprotkb:"Alpha(B)-crystallin"(gene name synonym)|uniprotkb:P23(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657444	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	ensembl:ENSMUSG00000032060(gene)|ensembl:ENSMUST00000034562(transcript)|ensembl:ENSMUST00000214962(transcript)|ensembl:ENSMUST00000216755(transcript)|ensembl:ENSMUST00000217475(transcript)|go:"GO:0001540"(amyloid-beta binding)|go:"GO:0001666"(response to hypoxia)|go:"GO:0002088"(lens development in camera-type eye)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005212"(structural constituent of eye lens)|go:"GO:0005576"(extracellular region)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006457"(protein folding)|go:"GO:0007021"(tubulin complex assembly)|go:"GO:0007517"(muscle organ development)|go:"GO:0008017"(microtubule binding)|go:"GO:0008092"(cytoskeletal protein binding)|go:"GO:0009986"(cell surface)|go:"GO:0010259"(multicellular organism aging)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0010941"(regulation of cell death)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015630"(microtubule cytoskeleton)|go:"GO:0030018"(Z disc)|go:"GO:0030308"(negative regulation of cell growth)|go:"GO:0030424"(axon)|go:"GO:0031109"(microtubule polymerization or depolymerization)|go:"GO:0031333"(negative regulation of protein-containing complex assembly)|go:"GO:0031430"(M band)|go:"GO:0031674"(I band)|go:"GO:0032355"(response to estradiol)|go:"GO:0032387"(negative regulation of intracellular transport)|go:"GO:0032432"(actin filament bundle)|go:"GO:0032991"(protein-containing complex)|go:"GO:0042542"(response to hydrogen peroxide)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043010"(camera-type eye development)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043154"(negative regulation of cysteine-type endopeptidase activity involved in apoptotic process)|go:"GO:0043197"(dendritic spine)|go:"GO:0043204"(perikaryon)|go:"GO:0043209"(myelin sheath)|go:"GO:0043292"(contractile fiber)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045202"(synapse)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0046872"(metal ion binding)|go:"GO:0050821"(protein stabilization)|go:"GO:0051082"(unfolded protein binding)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0060561"(apoptotic process involved in morphogenesis)|go:"GO:0071480"(cellular response to gamma radiation)|go:"GO:0097060"(synaptic membrane)|go:"GO:0097512"(cardiac myofibril)|go:"GO:1905907"(negative regulation of amyloid fibril formation)|go:"GO:2000378"(negative regulation of reactive oxygen species metabolic process)|interpro:IPR001436(Alpha crystallin/Heat shock protein)|interpro:IPR002068(Heat shock protein Hsp20)|interpro:IPR003090(Alpha-crystallin, N-terminal)|interpro:IPR008978(HSP20-like chaperone)|interpro:IPR037882|mint:P23927|reactome:R-MMU-3371571|refseq:XP_006510033.1|refseq:NP_034094.1|refseq:NP_001276711.1|refseq:NP_001276713.1|refseq:NP_001276714.1|dip:DIP-31060N	afcs:6701(primary-reference)|afcs:15868(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	rogid:LOp5smbeRceV8/P+Eaoh7p+24Vw10090	intact-crc:B228C8C41D18AB0B|rigid:+Xhf28SpRPusbDb1z4BecWSSI00	false	sufficient binding region:103-330	sufficient binding region:35-175	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q7TSH4	uniprotkb:P42227	intact:EBI-646843|uniprotkb:Q6A072|ensembl:ENSMUSP00000038881|ensembl:ENSMUSP00000102167	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:cp110_mouse(display_long)|uniprotkb:Cep110(gene name synonym)|uniprotkb:Ccp110(gene name)|psi-mi:Ccp110(display_short)|uniprotkb:Kiaa0419(gene name synonym)|uniprotkb:Cp110(gene name synonym)|uniprotkb:Centrosomal protein of 110 kDa(gene name synonym)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657454	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_892040.1|ensembl:ENSMUSG00000033904(gene)|ensembl:ENSMUST00000038650(transcript)|ensembl:ENSMUST00000106557(transcript)|go:"GO:0005737"(cytoplasm)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005929"(cilium)|go:"GO:0007099"(centriole replication)|go:"GO:0032053"(ciliary basal body organization)|go:"GO:0032465"(regulation of cytokinesis)|go:"GO:0032991"(protein-containing complex)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051298"(centrosome duplication)|go:"GO:1902018"(negative regulation of cilium assembly)|go:"GO:1903723"(negative regulation of centriole elongation)|interpro:IPR033207|reactome:R-MMU-2565942|reactome:R-MMU-380259|reactome:R-MMU-380270|reactome:R-MMU-380284|reactome:R-MMU-380320|reactome:R-MMU-5620912|reactome:R-MMU-5689880|reactome:R-MMU-8854518|reactome:R-MMU-9013424	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:55737(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Ma+OC215nDGgK9D4XMR9h7X4EV410090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:95472C61847086EB|rigid:NFp0dagXC8qpQO0vsbVpoLSw23w	false	sufficient binding region:487-797	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03172	uniprotkb:P63085	intact:EBI-646850	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:zep1_mouse(display_long)|uniprotkb:Transcription factor alphaA-CRYBP1(gene name synonym)|uniprotkb:Alpha A-crystallin-binding protein I(gene name synonym)|uniprotkb:Alpha A-crystallin-binding protein 1(gene name synonym)|uniprotkb:Hivep1(gene name)|psi-mi:Hivep1(display_short)|uniprotkb:Cryabp1(gene name synonym)|uniprotkb:Znf40(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657464	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR034729|interpro:IPR036236|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:14118(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2aZZR3UcsEIiv2Hn0nBPw4ih2F010090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:CF11280F1BCD32A7|rigid:zmW3Wv69nOvYYwKxQTDjKSsjdHk	false	sufficient binding region:1318-1470	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q03172	uniprotkb:P63085	intact:EBI-646850	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:zep1_mouse(display_long)|uniprotkb:Transcription factor alphaA-CRYBP1(gene name synonym)|uniprotkb:Alpha A-crystallin-binding protein I(gene name synonym)|uniprotkb:Alpha A-crystallin-binding protein 1(gene name synonym)|uniprotkb:Hivep1(gene name)|psi-mi:Hivep1(display_short)|uniprotkb:Cryabp1(gene name synonym)|uniprotkb:Znf40(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657494	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	interpro:IPR013087(Zinc finger, C2H2-type/integrase, DNA-binding)|interpro:IPR003604(Zinc finger, U1-type)|interpro:IPR034729|interpro:IPR036236|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005829"(cytosol)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0008270"(zinc ion binding)|go:"GO:0016604"(nuclear body)|go:"GO:0030509"(BMP signaling pathway)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0071837"(HMG box domain binding)|go:"GO:1990837"(sequence-specific double-stranded DNA binding)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:14118(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:2aZZR3UcsEIiv2Hn0nBPw4ih2F010090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:F4B6E202AA8572AC|rigid:zmW3Wv69nOvYYwKxQTDjKSsjdHk	false	sufficient binding region:1411-1589	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:O08605	uniprotkb:P63085	intact:EBI-646859	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:mknk1_mouse(display_long)|uniprotkb:MAP kinase signal-integrating kinase 1(gene name synonym)|uniprotkb:Mknk1(gene name)|psi-mi:Mknk1(display_short)|uniprotkb:Mnk1(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657504	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001272417.1|refseq:NP_067436.1|interpro:IPR011009(Protein kinase-like)|interpro:IPR000719(Protein kinase, core)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004683"(calmodulin-dependent protein kinase activity)|go:"GO:0005516"(calmodulin binding)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0006446"(regulation of translational initiation)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0009651"(response to salt stress)|go:"GO:0009931"(calcium-dependent protein serine/threonine kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0046872"(metal ion binding)|go:"GO:0097192"(extrinsic apoptotic signaling pathway in absence of ligand)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0046777"(protein autophosphorylation)|reactome:R-MMU-1295596	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:12169(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:nQ9d4dPH4qSOOl8O0nNMUXa46/w10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:203D166E27667771|rigid:GWjaCTbXKpqOv+Pjs9O0EwmzHUw	false	sufficient binding region:222-393	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z2B9	uniprotkb:P63085	intact:EBI-412887|uniprotkb:Q91X18|uniprotkb:Q3U3M8|ensembl:ENSMUSP00000159422	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:ks6a4_mouse(display_long)|uniprotkb:Rps6ka4(gene name)|psi-mi:Rps6ka4(display_short)|uniprotkb:Msk2(gene name synonym)|uniprotkb:Nuclear mitogen- and stress-activated protein kinase 2(gene name synonym)|uniprotkb:90 kDa ribosomal protein S6 kinase 4(gene name synonym)|uniprotkb:RSK-like protein kinase(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657534	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_064308.2|ensembl:ENSMUSG00000118668(gene)|ensembl:ENSMUST00000239527(transcript)|go:"GO:0000287"(magnesium ion binding)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006954"(inflammatory response)|go:"GO:0016572"(histone phosphorylation)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0035066"(positive regulation of histone acetylation)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0043987"(histone H3-S10 phosphorylation)|go:"GO:0043988"(histone H3-S28 phosphorylation)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0070498"(interleukin-1-mediated signaling pathway)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|interpro:IPR000719(Protein kinase, core)|interpro:IPR000961(Protein kinase, C-terminal)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR011009(Protein kinase-like)|interpro:IPR016239(Ribosomal protein S6 kinase II)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|interpro:IPR017892|interpro:IPR037714|go:"GO:0033129"(positive regulation of histone phosphorylation)	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:18366(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0KS9aQPZHUihMySfnnDnLkZl5dQ10090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:B515F5CD17B19398|rigid:KEg9r3dkdMgS8ch+RiEGTDQ44W0	false	sufficient binding region:511-773	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8CJ40	uniprotkb:P63085	intact:EBI-646873|uniprotkb:A2AA81|uniprotkb:Q7TQL2|uniprotkb:Q80U01|uniprotkb:Q8R0B9|ensembl:ENSMUSP00000099549	intact:EBI-397697|uniprotkb:P27703|uniprotkb:Q3V1U6|ensembl:ENSMUSP00000156154|ensembl:ENSMUSP00000065983|ensembl:ENSMUSP00000111396	psi-mi:crocc_mouse(display_long)|uniprotkb:Ciliary rootlet coiled-coil protein(gene name synonym)|uniprotkb:Crocc(gene name)|psi-mi:Crocc(display_short)|uniprotkb:Kiaa0445(gene name synonym)	psi-mi:mk01_mouse(display_long)|uniprotkb:Mapk1(gene name)|psi-mi:Mapk1(display_short)|uniprotkb:Erk2(gene name synonym)|uniprotkb:Mapk(gene name synonym)|uniprotkb:Prkm1(gene name synonym)|uniprotkb:Extracellular signal-regulated kinase 2(gene name synonym)|uniprotkb:Mitogen-activated protein kinase 2(gene name synonym)|uniprotkb:MAP kinase isoform p42(gene name synonym)|uniprotkb:ERT1(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657554	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001139430.1|refseq:NP_742120.2|ensembl:ENSMUSG00000040860(gene)|ensembl:ENSMUST00000102491(transcript)|go:"GO:0001917"(photoreceptor inner segment)|go:"GO:0003779"(actin binding)|go:"GO:0005198"(structural molecule activity)|go:"GO:0005200"(structural constituent of cytoskeleton)|go:"GO:0005813"(centrosome)|go:"GO:0005814"(centriole)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0007098"(centrosome cycle)|go:"GO:0008104"(protein localization)|go:"GO:0010457"(centriole-centriole cohesion)|go:"GO:0010669"(epithelial structure maintenance)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0019894"(kinesin binding)|go:"GO:0032053"(ciliary basal body organization)|go:"GO:0033365"(protein localization to organelle)|go:"GO:0035253"(ciliary rootlet)|go:"GO:0045494"(photoreceptor cell maintenance)|go:"GO:0045724"(positive regulation of cilium assembly)|go:"GO:0051656"(establishment of organelle localization)|go:"GO:0097729"(9+2 motile cilium)|go:"GO:0120219"(subapical part of cell)|go:"GO:1903566"(positive regulation of protein localization to cilium)|interpro:IPR026733	refseq:NP_001033752.1|refseq:NP_036079.1|refseq:XP_006522210.1|dip:DIP-661N|ensembl:ENSMUST00000069107(transcript)|ensembl:ENSMUST00000115731(transcript)|ensembl:ENSMUST00000232611(transcript)|go:"GO:0000165"(MAPK cascade)|go:"GO:0001784"(phosphotyrosine residue binding)|go:"GO:0003690"(double-stranded DNA binding)|go:"GO:0004672"(protein kinase activity)|go:"GO:0004674"(protein serine/threonine kinase activity)|go:"GO:0004707"(MAP kinase activity)|go:"GO:0004708"(MAP kinase kinase activity)|go:"GO:0005524"(ATP binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005769"(early endosome)|go:"GO:0005770"(late endosome)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005815"(microtubule organizing center)|go:"GO:0005829"(cytosol)|go:"GO:0005856"(cytoskeleton)|go:"GO:0005886"(plasma membrane)|go:"GO:0005901"(caveola)|go:"GO:0005925"(focal adhesion)|go:"GO:0006351"(transcription, DNA-templated)|go:"GO:0006468"(protein phosphorylation)|go:"GO:0006915"(apoptotic process)|go:"GO:0006974"(cellular response to DNA damage stimulus)|go:"GO:0007049"(cell cycle)|go:"GO:0007165"(signal transduction)|go:"GO:0007166"(cell surface receptor signaling pathway)|go:"GO:0007507"(heart development)|go:"GO:0007568"(aging)|go:"GO:0008353"(RNA polymerase II CTD heptapeptide repeat kinase activity)|go:"GO:0009636"(response to toxic substance)|go:"GO:0009887"(animal organ morphogenesis)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010759"(positive regulation of macrophage chemotaxis)|go:"GO:0010800"(positive regulation of peptidyl-threonine phosphorylation)|go:"GO:0014032"(neural crest cell development)|go:"GO:0014069"(postsynaptic density)|go:"GO:0015966"(diadenosine tetraphosphate biosynthetic process)|go:"GO:0016301"(kinase activity)|go:"GO:0018105"(peptidyl-serine phosphorylation)|go:"GO:0018107"(peptidyl-threonine phosphorylation)|go:"GO:0019233"(sensory perception of pain)|go:"GO:0019858"(cytosine metabolic process)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019902"(phosphatase binding)|go:"GO:0030278"(regulation of ossification)|go:"GO:0030424"(axon)|go:"GO:0030641"(regulation of cellular pH)|go:"GO:0030878"(thyroid gland development)|go:"GO:0031143"(pseudopodium)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031647"(regulation of protein stability)|go:"GO:0031663"(lipopolysaccharide-mediated signaling pathway)|go:"GO:0032212"(positive regulation of telomere maintenance via telomerase)|go:"GO:0032496"(response to lipopolysaccharide)|go:"GO:0032839"(dendrite cytoplasm)|go:"GO:0032872"(regulation of stress-activated MAPK cascade)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033598"(mammary gland epithelial cell proliferation)|go:"GO:0034198"(cellular response to amino acid starvation)|go:"GO:0034614"(cellular response to reactive oxygen species)|go:"GO:0035094"(response to nicotine)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0038127"(ERBB signaling pathway)|go:"GO:0042307"(positive regulation of protein import into nucleus)|go:"GO:0042473"(outer ear morphogenesis)|go:"GO:0042802"(identical protein binding)|go:"GO:0043204"(perikaryon)|go:"GO:0043330"(response to exogenous dsRNA)|go:"GO:0043627"(response to estrogen)|go:"GO:0045596"(negative regulation of cell differentiation)|go:"GO:0045727"(positive regulation of translation)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0046697"(decidualization)|go:"GO:0048538"(thymus development)|go:"GO:0050852"(T cell receptor signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0051090"(regulation of DNA-binding transcription factor activity)|go:"GO:0051403"(stress-activated MAPK cascade)|go:"GO:0051493"(regulation of cytoskeleton organization)|go:"GO:0051973"(positive regulation of telomerase activity)|go:"GO:0060020"(Bergmann glial cell differentiation)|go:"GO:0060045"(positive regulation of cardiac muscle cell proliferation)|go:"GO:0060291"(long-term synaptic potentiation)|go:"GO:0060324"(face development)|go:"GO:0060425"(lung morphogenesis)|go:"GO:0060440"(trachea formation)|go:"GO:0060716"(labyrinthine layer blood vessel development)|go:"GO:0061308"(cardiac neural crest cell development involved in heart development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070849"(response to epidermal growth factor)|go:"GO:0071276"(cellular response to cadmium ion)|go:"GO:0071310"(cellular response to organic substance)|go:"GO:0071356"(cellular response to tumor necrosis factor)|go:"GO:0072584"(caveolin-mediated endocytosis)|go:"GO:0072686"(mitotic spindle)|go:"GO:0090170"(regulation of Golgi inheritance)|go:"GO:0097011"(cellular response to granulocyte macrophage colony-stimulating factor stimulus)|go:"GO:0106310"(protein serine kinase activity)|go:"GO:0106311"|go:"GO:0120041"(positive regulation of macrophage proliferation)|go:"GO:1903351"(cellular response to dopamine)|go:"GO:1904355"(positive regulation of telomere capping)|go:"GO:2000641"(regulation of early endosome to late endosome transport)|interpro:IPR000719(Protein kinase, core)|interpro:IPR003527(MAP kinase, conserved site)|interpro:IPR008271(Serine/threonine protein kinase, active site)|interpro:IPR008349(ERK1/2 MAP kinase)|interpro:IPR011009(Protein kinase-like)|interpro:IPR017441(Protein kinase ATP binding, conserved site)|mint:P63085|reactome:R-MMU-111995|reactome:R-MMU-112409|reactome:R-MMU-112411|reactome:R-MMU-1295596|reactome:R-MMU-162658|reactome:R-MMU-170968|reactome:R-MMU-198753|reactome:R-MMU-202670|reactome:R-MMU-2029482|reactome:R-MMU-2559580|reactome:R-MMU-2559582|reactome:R-MMU-2559585|reactome:R-MMU-2871796|reactome:R-MMU-3371453|reactome:R-MMU-375165|reactome:R-MMU-437239|reactome:R-MMU-445144|reactome:R-MMU-450341|reactome:R-MMU-456926|reactome:R-MMU-5654726|reactome:R-MMU-5654727|reactome:R-MMU-5654732|reactome:R-MMU-5654733|reactome:R-MMU-5663213|reactome:R-MMU-5668599|reactome:R-MMU-5673001|reactome:R-MMU-5674135|reactome:R-MMU-5674499|reactome:R-MMU-5675221|reactome:R-MMU-6798695|reactome:R-MMU-6811558|reactome:R-MMU-74749|reactome:R-MMU-881907|reactome:R-MMU-8939211|reactome:R-MMU-9627069|reactome:R-MMU-9634635|ensembl:ENSMUSG00000063358(gene)|reactome:R-MMU-9634638|reactome:R-MMU-982772	afcs:17112(primary-reference)|afcs:58147(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:Ot15r5R8qOlQpFKf+8ccn+XuaH810090	rogid:4STZhl2O+Ilh0lj8wQp8y2vVehA10090	intact-crc:9B0A310BD0B6557F|rigid:KddF1a6jHFdhyTJY8N7dV4KdyFg	false	sufficient binding region:41-535	sufficient binding region:1-358	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K3X6	uniprotkb:P39428	intact:EBI-646879|uniprotkb:Q9D8A5|uniprotkb:Q148R3|ensembl:ENSMUSP00000033201	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:ans4b_mouse(display_long)|uniprotkb:Harmonin-interacting ankyrin repeat-containing protein(gene name synonym)|uniprotkb:Anks4b(gene name)|psi-mi:Anks4b(display_short)|uniprotkb:Harp(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657564	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_082361.2|ensembl:ENSMUSG00000030909(gene)|ensembl:ENSMUST00000033201(transcript)|go:"GO:0005789"(endoplasmic reticulum membrane)|go:"GO:0005886"(plasma membrane)|go:"GO:0005902"(microvillus)|go:"GO:0005903"(brush border)|go:"GO:0030154"(cell differentiation)|go:"GO:0034622"|go:"GO:0034976"(response to endoplasmic reticulum stress)|go:"GO:1904106"(protein localization to microvillus)|go:"GO:1904970"(brush border assembly)|interpro:IPR001660(Sterile alpha motif SAM)|interpro:IPR002110(Ankyrin)|interpro:IPR013761(Sterile alpha motif-type)|interpro:IPR020683|interpro:IPR036770|interpro:IPR037601|rcsb pdb:5F3X|rcsb pdb:5F3Y	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:55688(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:8OV95L5TI4bGkmO7lZ83gCcpogA10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:06BCE8AA4C5D16F0|rigid:jhlFvVxlGdLsHwyD0K3q9wvMxQY	false	sufficient binding region:156-305	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P63002	uniprotkb:P39428	intact:EBI-646888|uniprotkb:Q06195|ensembl:ENSMUSP00000002518	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:tle5_mouse(display_long)|uniprotkb:Tle5(gene name)|psi-mi:Tle5(display_short)|uniprotkb:Aes(gene name synonym)|uniprotkb:Amino-terminal enhancer of split(gene name synonym)|uniprotkb:Esp1(gene name synonym)|uniprotkb:Grg(gene name synonym)|uniprotkb:Grg-5(gene name synonym)|uniprotkb:Grg5(gene name synonym)|uniprotkb:Groucho-related protein 5(gene name synonym)|uniprotkb:Protein ESP1(gene name synonym)|uniprotkb:Protein GRG(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657574	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034477.1|ensembl:ENSMUSG00000054452(gene)|ensembl:ENSMUST00000002518(transcript)|go:"GO:0000122"(negative regulation of transcription by RNA polymerase II)|go:"GO:0001501"(skeletal system development)|go:"GO:0003714"(transcription corepressor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0031668"(cellular response to extracellular stimulus)|go:"GO:0032091"(negative regulation of protein binding)|go:"GO:0040008"(regulation of growth)|go:"GO:0042802"(identical protein binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0060761"(negative regulation of response to cytokine stimulus)|go:"GO:0070555"(response to interleukin-1)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:0140297"(DNA-binding transcription factor binding)|go:"GO:2000210"(positive regulation of anoikis)|interpro:IPR005617(Groucho/TLE, N-terminal Q-rich region)|interpro:IPR009146(Groucho/transducin-like enhancer)|mint:P63002	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:6445(secondary-ac)	-	-	caution:The prey construct contains 13 additional amino acids at the amino terminus.|dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:3rMMpP0J+0tEUlSLA/PofvANFjU10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:3056376A057BF669|rigid:MZHQnJKB2ARuG/kSbXUpKV0Kf2Q	false	sufficient binding region:1-179	sufficient binding region:205-409	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8BJS4	uniprotkb:P39428	intact:EBI-646914|uniprotkb:Q3TBU0|uniprotkb:Q3U160|uniprotkb:Q6B4H2|ensembl:ENSMUSP00000047864	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:sun2_mouse(display_long)|uniprotkb:Sad1/unc-84 protein-like 2(gene name synonym)|uniprotkb:Sun2(gene name)|psi-mi:Sun2(display_short)|uniprotkb:Unc84b(gene name synonym)|uniprotkb:Protein unc-84 homolog B(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657584	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001192274.1|refseq:NP_001192275.1|refseq:NP_919323.2|dip:DIP-49694N|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0005521"(lamin binding)|go:"GO:0005635"(nuclear envelope)|go:"GO:0005637"(nuclear inner membrane)|go:"GO:0005639"(integral component of nuclear inner membrane)|go:"GO:0006998"(nuclear envelope organization)|go:"GO:0010008"(endosome membrane)|go:"GO:0021817"(nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031022"(nuclear migration along microfilament)|go:"GO:0031965"(nuclear membrane)|go:"GO:0034993"(meiotic nuclear membrane microtubule tethering complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0043495"(protein-membrane adaptor activity)|go:"GO:0051321"(meiotic cell cycle)|go:"GO:0051642"(centrosome localization)|go:"GO:0090292"(nuclear matrix anchoring at nuclear membrane)|go:"GO:0140444"(cytoskeleton-nuclear membrane anchor activity)|interpro:IPR012919(Sad1/UNC-like, C-terminal)|interpro:IPR030272|interpro:IPR040994|rcsb pdb:5ED8|rcsb pdb:5ED9|ensembl:ENSMUSG00000042524(gene)|ensembl:ENSMUST00000046259(transcript)|go:"GO:0000781"(chromosome, telomeric region)	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:55738(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:F+gOC6NhX2BXG3iU0TI2DNxYWYQ10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:0AC3C1BB329ECAD6|rigid:BHwfozLLcQanDOoLBLGQL55uilQ	false	sufficient binding region:298-482	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9Z104	uniprotkb:P39428	intact:EBI-646920|uniprotkb:Q9NSF7|uniprotkb:Q9NSF8|ensembl:ENSMUSP00000020454|ensembl:ENSMUSP00000100960|ensembl:ENSMUSP00000100961|ensembl:ENSMUSP00000128807	intact:EBI-520123|intact:EBI-646694|uniprotkb:Q8CE28|ensembl:ENSMUSP00000028234|ensembl:ENSMUSP00000108687|ensembl:ENSMUSP00000130759	psi-mi:hm20b_mouse(display_long)|uniprotkb:HMG box-containing protein 20B(gene name synonym)|uniprotkb:Structural DNA-binding protein BRAF35(gene name synonym)|uniprotkb:BRCA2-associated factor 35(gene name synonym)|uniprotkb:Hmg20b(gene name)|psi-mi:Hmg20b(display_short)|uniprotkb:Braf35(gene name synonym)|uniprotkb:Hmgx2(gene name synonym)|uniprotkb:Smarce1r(gene name synonym)	psi-mi:traf1_mouse(display_long)|uniprotkb:Traf1(gene name)|psi-mi:Traf1(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657605	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001156637.1|refseq:NP_001156638.1|refseq:NP_034570.1|ensembl:ENSMUSG00000020232(gene)|ensembl:ENSMUST00000020454(transcript)|ensembl:ENSMUST00000105323(transcript)|ensembl:ENSMUST00000105324(transcript)|ensembl:ENSMUST00000167481(transcript)|go:"GO:0000400"(four-way junction DNA binding)|go:"GO:0000794"(condensed nuclear chromosome)|go:"GO:0002111"(BRCA2-BRAF35 complex)|go:"GO:0003677"(DNA binding)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0006325"(chromatin organization)|go:"GO:0006338"(chromatin remodeling)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0007049"(cell cycle)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0016604"(nuclear body)|go:"GO:0033234"(negative regulation of protein sumoylation)|go:"GO:0035914"(skeletal muscle cell differentiation)|go:"GO:0045666"(positive regulation of neuron differentiation)|interpro:IPR009071(High mobility group box, HMG)|interpro:IPR036910|rcsb pdb:2CRJ|reactome:R-MMU-3214815|reactome:R-MMU-983231	refseq:NP_033447.2|ensembl:ENSMUSG00000026875(gene)|ensembl:ENSMUST00000028234(transcript)|ensembl:ENSMUST00000113064(transcript)|ensembl:ENSMUST00000172159(transcript)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0006915"(apoptotic process)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0042802"(identical protein binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:2001236"(regulation of extrinsic apoptotic signaling pathway)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR027136|interpro:IPR032070|interpro:IPR037306|interpro:IPR043211|reactome:R-MMU-5357905|reactome:R-MMU-5357956|refseq:XP_011237352.1|refseq:XP_011237353.1|refseq:XP_011237354.1|refseq:XP_011237355.1|refseq:XP_011237356.1|refseq:NP_001313530.1|refseq:XP_017172618.1|dip:DIP-260N	afcs:55765(primary-reference)|afcs:23603(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:FqfdR1RK6T2N0BYXOD5lfPay8AY10090	rogid:w/0cx287jcp6ppPA4xKjaKmkjDc10090	intact-crc:31B9B4CFD7AF23A9|rigid:rmQtlbizNascaTRbPsASpl0MCXI	false	sufficient binding region:88-317	sufficient binding region:100-270	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q61140	uniprotkb:Q9QXJ2	intact:EBI-77088|uniprotkb:Q6PFF9|uniprotkb:Q60869|ensembl:ENSMUSP00000129584	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:bcar1_mouse(display_long)|uniprotkb:Bcar1(gene name)|psi-mi:Bcar1(display_short)|uniprotkb:Cas(gene name synonym)|uniprotkb:Crkas(gene name synonym)|uniprotkb:p130cas(gene name synonym)|uniprotkb:CRK-associated substrate(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657794	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001185768.1|refseq:NP_034084.2|rcsb pdb:5W93|reactome:R-MMU-186763|reactome:R-MMU-372708|reactome:R-MMU-4420097|reactome:R-MMU-8849471|ensembl:ENSMUSG00000031955(gene)|ensembl:ENSMUST00000166232(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0005925"(focal adhesion)|go:"GO:0007015"(actin filament organization)|go:"GO:0007155"(cell adhesion)|go:"GO:0007169"(transmembrane receptor protein tyrosine kinase signaling pathway)|go:"GO:0007173"(epidermal growth factor receptor signaling pathway)|go:"GO:0007186"(G protein-coupled receptor signaling pathway)|go:"GO:0007229"(integrin-mediated signaling pathway)|go:"GO:0008286"(insulin receptor signaling pathway)|go:"GO:0010595"(positive regulation of endothelial cell migration)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0016020"(membrane)|go:"GO:0016477"(cell migration)|go:"GO:0017124"(SH3 domain binding)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019904"(protein domain specific binding)|go:"GO:0030027"(lamellipodium)|go:"GO:0030036"(actin cytoskeleton organization)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030424"(axon)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0048008"(platelet-derived growth factor receptor signaling pathway)|go:"GO:0048010"(vascular endothelial growth factor receptor signaling pathway)|go:"GO:0048011"(neurotrophin TRK receptor signaling pathway)|go:"GO:0048012"(hepatocyte growth factor receptor signaling pathway)|go:"GO:0050851"(antigen receptor-mediated signaling pathway)|go:"GO:0050853"(B cell receptor signaling pathway)|go:"GO:0060326"(cell chemotaxis)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0086100"(endothelin receptor signaling pathway)|go:"GO:0090527"(actin filament reorganization)|go:"GO:1900025"(negative regulation of substrate adhesion-dependent cell spreading)|go:"GO:1990859"(cellular response to endothelin)|interpro:IPR001452(Src homology-3)|interpro:IPR014928(Serine rich protein interaction)|interpro:IPR021901|interpro:IPR028848|interpro:IPR035745|interpro:IPR036028|interpro:IPR037362|interpro:IPR038319|mint:Q61140	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:15865(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:sbyvN4CE9k2skJV5C/LySCgu++E10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:6B30778A3601996C|rigid:9HO51LHauHFizvcZkMGpSJNhU14	false	sufficient binding region:502-682	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ER00	uniprotkb:Q9QXJ2	intact:EBI-646997|uniprotkb:Q3UIV9|uniprotkb:Q921T9|ensembl:ENSMUSP00000030698	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:stx12_mouse(display_long)|uniprotkb:Stx12(gene name)|psi-mi:Stx12(display_short)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657804	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_598648.1|ensembl:ENSMUSG00000028879(gene)|ensembl:ENSMUST00000030698(transcript)|go:"GO:0000045"(autophagosome assembly)|go:"GO:0000139"(Golgi membrane)|go:"GO:0000149"(SNARE binding)|go:"GO:0000407"(phagophore assembly site)|go:"GO:0005484"(SNAP receptor activity)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0006886"(intracellular protein transport)|go:"GO:0006906"(vesicle fusion)|go:"GO:0008021"(synaptic vesicle)|go:"GO:0012505"(endomembrane system)|go:"GO:0016021"(integral component of membrane)|go:"GO:0016189"(synaptic vesicle to endosome fusion)|go:"GO:0031083"(BLOC-1 complex)|go:"GO:0031201"(SNARE complex)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0033344"(cholesterol efflux)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:0045121"(membrane raft)|go:"GO:0045335"(phagocytic vesicle)|go:"GO:0048278"(vesicle docking)|go:"GO:0050821"(protein stabilization)|go:"GO:0055038"(recycling endosome membrane)|go:"GO:0098837"(postsynaptic recycling endosome)|interpro:IPR000727(Target SNARE coiled-coil region)|interpro:IPR006011(Syntaxin, N-terminal)|interpro:IPR006012(Syntaxin/epimorphin, conserved site)|interpro:IPR010989(t-SNARE)|mint:Q9ER00|go:"GO:0030285"(integral component of synaptic vesicle membrane)	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:29928(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:wLDB+JLvf6XfFv8HHbpZtODgH+k10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:53EF462293F182A3|rigid:+IKwqvZOHrfu7+T4cg+sX4T+7EI	false	sufficient binding region:47-186	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q8K3G9	uniprotkb:Q9QXJ2	intact:EBI-647007|uniprotkb:Q99LT7|ensembl:ENSMUSP00000020500	intact:EBI-646643|ensembl:ENSMUSP00000082855	psi-mi:dp13b_mouse(display_long)|uniprotkb:Adapter protein containing PH domain, PTB domain and leucine zipper motif 2(gene name synonym)|uniprotkb:Appl2(gene name)|psi-mi:Appl2(display_short)|uniprotkb:Dip13b(gene name synonym)|uniprotkb:Dip3b(gene name synonym)	psi-mi:q9qxj2_mouse(display_long)|uniprotkb:Stat2(gene name)|psi-mi:Stat2(display_short)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657814	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_660255.1|ensembl:ENSMUSG00000020263(gene)|ensembl:ENSMUST00000020500(transcript)|go:"GO:0001726"(ruffle)|go:"GO:0001786"(phosphatidylserine binding)|go:"GO:0002024"(diet induced thermogenesis)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0005768"(endosome)|go:"GO:0005886"(plasma membrane)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0007049"(cell cycle)|go:"GO:0007179"(transforming growth factor beta receptor signaling pathway)|go:"GO:0008283"(cell population proliferation)|go:"GO:0009631"(cold acclimation)|go:"GO:0010008"(endosome membrane)|go:"GO:0010762"(regulation of fibroblast migration)|go:"GO:0016020"(membrane)|go:"GO:0023052"(signaling)|go:"GO:0031267"(small GTPase binding)|go:"GO:0031410"(cytoplasmic vesicle)|go:"GO:0031901"(early endosome membrane)|go:"GO:0031982"(vesicle)|go:"GO:0032009"(early phagosome)|go:"GO:0032587"(ruffle membrane)|go:"GO:0033211"(adiponectin-activated signaling pathway)|go:"GO:0034143"(regulation of toll-like receptor 4 signaling pathway)|go:"GO:0035091"(phosphatidylinositol binding)|go:"GO:0035729"(cellular response to hepatocyte growth factor stimulus)|go:"GO:0036186"(early phagosome membrane)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042802"(identical protein binding)|go:"GO:0044354"(macropinosome)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045088"(regulation of innate immune response)|go:"GO:0046322"(negative regulation of fatty acid oxidation)|go:"GO:0046325"(negative regulation of glucose import)|go:"GO:0050768"(negative regulation of neurogenesis)|go:"GO:0051289"(protein homotetramerization)|go:"GO:0060100"(positive regulation of phagocytosis, engulfment)|go:"GO:0120162"(positive regulation of cold-induced thermogenesis)|go:"GO:1900016"(negative regulation of cytokine production involved in inflammatory response)|go:"GO:1900077"(negative regulation of cellular response to insulin stimulus)|go:"GO:1905303"(positive regulation of macropinocytosis)|go:"GO:1905451"(positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis)|go:"GO:2000045"(regulation of G1/S transition of mitotic cell cycle)|go:"GO:2000178"(negative regulation of neural precursor cell proliferation)|interpro:IPR001849(Pleckstrin-like)|interpro:IPR006020(Phosphotyrosine interaction region)|interpro:IPR011993(Pleckstrin homology-type)|interpro:IPR027267|go:"GO:0042803"(protein homodimerization activity)	refseq:NP_064347.1|ensembl:ENSMUSG00000040033(gene)|ensembl:ENSMUST00000085708(transcript)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005737"(cytoplasm)|go:"GO:0007165"(signal transduction)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR022756|interpro:IPR035854|interpro:IPR036535|interpro:IPR036860	afcs:18399(primary-reference)|afcs:58145(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:wd57HQ8H/qlUZQ3kRbY5nhqnJ/Y10090	rogid:rqLwSu56f3fYSQdaEITgDU0mT9010090	intact-crc:A163EC94A9887D94|rigid:QYFCRtBMn5mDG06FJIRLnzO3NMc	false	sufficient binding region:36-171	sufficient binding region:1-300	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P50284	uniprotkb:P39429	intact:EBI-647023|ensembl:ENSMUSP00000032489	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	psi-mi:tnr3_mouse(display_long)|uniprotkb:Lymphotoxin-beta receptor(gene name synonym)|uniprotkb:Ltbr(gene name)|psi-mi:Ltbr(display_short)|uniprotkb:Tnfcr(gene name synonym)|uniprotkb:Tnfrsf3(gene name synonym)	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657824	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_034866.1|dip:DIP-49695N|ensembl:ENSMUSG00000030339(gene)|ensembl:ENSMUST00000032489(transcript)|go:"GO:0005794"(Golgi apparatus)|go:"GO:0005886"(plasma membrane)|go:"GO:0006955"(immune response)|go:"GO:0016021"(integral component of membrane)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0042802"(identical protein binding)|go:"GO:0043011"(myeloid dendritic cell differentiation)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0048535"(lymph node development)|go:"GO:0071260"(cellular response to mechanical stimulus)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001368(TNFR/CD27/30/40/95 cysteine-rich region)|interpro:IPR017349(Tumour necrosis factor receptor superfamily member 3)|interpro:IPR033997|mint:P50284|reactome:R-MMU-5668541|reactome:R-MMU-5676594|go:"GO:0006915"(apoptotic process)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	afcs:53738(primary-reference)|afcs:16341(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4ixbHyVjgcKKRm9BtEemaW9e9h810090	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	intact-crc:263DC614AF36852E|rigid:8lzq1yM8enhnolY5adpTHBiJmcY	false	sufficient binding region:329-415	sufficient binding region:293-501	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:P39429	uniprotkb:Q6P1E1-1	intact:EBI-520016|ensembl:ENSMUSP00000028311|uniprotkb:O54896|uniprotkb:A2AJA3	intact:EBI-647043|ensembl:ENSMUSP00000124863	psi-mi:traf2_mouse(display_long)|uniprotkb:Traf2(gene name)|psi-mi:Traf2(display_short)|uniprotkb:E3 ubiquitin-protein ligase TRAF2(gene name synonym)|uniprotkb:RING-type E3 ubiquitin transferase TRAF2(gene name synonym)	psi-mi:q6p1e1-1(display_long)|uniprotkb:Zmiz1(gene name)|psi-mi:Zmiz1(display_short)|uniprotkb:Rai17(gene name synonym)|uniprotkb:Zimp10(gene name synonym)|uniprotkb:PIAS-like protein Zimp10(gene name synonym)|uniprotkb:Retinoic acid-induced protein 17(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657834	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|ensembl:ENSMUSG00000026942(gene)|ensembl:ENSMUST00000028311(transcript)|go:"GO:0000151"(ubiquitin ligase complex)|go:"GO:0002637"(regulation of immunoglobulin production)|go:"GO:0002726"(positive regulation of T cell cytokine production)|go:"GO:0002947"(tumor necrosis factor receptor superfamily complex)|go:"GO:0004842"(ubiquitin-protein transferase activity)|go:"GO:0005164"(tumor necrosis factor receptor binding)|go:"GO:0005174"(CD40 receptor binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005829"(cytosol)|go:"GO:0005938"(cell cortex)|go:"GO:0006915"(apoptotic process)|go:"GO:0007165"(signal transduction)|go:"GO:0007250"(activation of NF-kappaB-inducing kinase activity)|go:"GO:0008270"(zinc ion binding)|go:"GO:0009898"(cytoplasmic side of plasma membrane)|go:"GO:0012506"(vesicle membrane)|go:"GO:0019899"(enzyme binding)|refseq:NP_033448.2|reactome:R-MMU-5218900|reactome:R-MMU-5357786|reactome:R-MMU-5357905|reactome:R-MMU-5357956|reactome:R-MMU-5668541|reactome:R-MMU-5675482|reactome:R-MMU-5676594|reactome:R-MMU-5689880|reactome:R-MMU-69416|reactome:R-MMU-75893|go:"GO:0023019"(signal transduction involved in regulation of gene expression)|go:"GO:0030163"(protein catabolic process)|go:"GO:0030674"(protein-macromolecule adaptor activity)|go:"GO:0031435"(mitogen-activated protein kinase kinase kinase binding)|go:"GO:0031625"(ubiquitin protein ligase binding)|go:"GO:0031996"(thioesterase binding)|go:"GO:0032743"(positive regulation of interleukin-2 production)|go:"GO:0032991"(protein-containing complex)|go:"GO:0033209"(tumor necrosis factor-mediated signaling pathway)|go:"GO:0034351"(negative regulation of glial cell apoptotic process)|go:"GO:0034622"|go:"GO:0035631"(CD40 receptor complex)|go:"GO:0042802"(identical protein binding)|go:"GO:0042981"(regulation of apoptotic process)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043120"(tumor necrosis factor binding)|go:"GO:0043122"(regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043123"(positive regulation of I-kappaB kinase/NF-kappaB signaling)|go:"GO:0043254"(regulation of protein-containing complex assembly)|go:"GO:0043507"(positive regulation of JUN kinase activity)|go:"GO:0044877"(protein-containing complex binding)|go:"GO:0045121"(membrane raft)|go:"GO:0046328"(regulation of JNK cascade)|go:"GO:0046330"(positive regulation of JNK cascade)|go:"GO:0046625"(sphingolipid binding)|go:"GO:0048255"(mRNA stabilization)|go:"GO:0051091"(positive regulation of DNA-binding transcription factor activity)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051865"(protein autoubiquitination)|go:"GO:0070534"(protein K63-linked ubiquitination)|go:"GO:0071732"(cellular response to nitric oxide)|go:"GO:0097057"(TRAF2-GSTP1 complex)|go:"GO:0097300"(programmed necrotic cell death)|go:"GO:0097400"(interleukin-17-mediated signaling pathway)|go:"GO:1903265"(positive regulation of tumor necrosis factor-mediated signaling pathway)|go:"GO:1903721"(positive regulation of I-kappaB phosphorylation)|go:"GO:1990604"(IRE1-TRAF2-ASK1 complex)|go:"GO:2001238"(positive regulation of extrinsic apoptotic signaling pathway)|interpro:IPR001293(Zinc finger, TRAF-type)|interpro:IPR001841(Zinc finger, RING-type)|interpro:IPR002083(MATH)|interpro:IPR008974(TRAF-like)|interpro:IPR012227(TNF receptor-associated factor TRAF)|interpro:IPR013083(Zinc finger, RING/FYVE/PHD-type)|interpro:IPR017907|interpro:IPR018957|interpro:IPR027133|interpro:IPR032070|interpro:IPR037305|interpro:IPR043211|mint:P39429|reactome:R-MMU-3371378|refseq:NP_001277342.1|dip:DIP-468N	intact:EBI-647033(zim10_mouse)|ensembl:ENSMUSG00000007817(gene)|ensembl:ENSMUST00000162645(transcript)	afcs:53738(primary-reference)|afcs:58153(secondary-ac)	-	isoform-comment:No experimental confirmation available.	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:4bEtgL7iKGmKF7YXm9vpRd2CHww10090	rogid:YDCZA1JO5KiYFqN/y8VMYNLfUTA10090	intact-crc:B65BA0F8BB1FB90D|rigid:Ia+xSY7xcEBa7c8d/WfFkZ3RGpM	false	sufficient binding region:293-501	sufficient binding region:555-972	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9ERD8	uniprotkb:Q62406-1	intact:EBI-647060|uniprotkb:Q8BH45|uniprotkb:Q91X89|ensembl:ENSMUSP00000023074	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:parvg_mouse(display_long)|uniprotkb:Parvg(gene name)|psi-mi:Parvg(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657864	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_001155972.1|refseq:NP_071716.3|refseq:XP_011244008.1|ensembl:ENSMUSG00000022439(gene)|ensembl:ENSMUST00000023074(transcript)|go:"GO:0003779"(actin binding)|go:"GO:0005737"(cytoplasm)|go:"GO:0005925"(focal adhesion)|go:"GO:0007163"(establishment or maintenance of cell polarity)|go:"GO:0015629"(actin cytoskeleton)|go:"GO:0030031"(cell projection assembly)|go:"GO:0031532"(actin cytoskeleton reorganization)|go:"GO:0034446"(substrate adhesion-dependent cell spreading)|interpro:IPR001715(Calponin-like actin-binding)|interpro:IPR028433|interpro:IPR036872|go:"GO:0005886"(plasma membrane)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:24153(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:0M9tnXAjmF+2EQtmFznsK2s7SKo10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:4CB47643CE36B67A|rigid:VnUN9PRPRG6BYputLtq9+k2P4D8	false	sufficient binding region:41-331	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
uniprotkb:Q9QUN9	uniprotkb:Q62406-1	intact:EBI-647066|ensembl:ENSMUSP00000033036	intact:EBI-488313|ensembl:ENSMUSP00000064448|ensembl:ENSMUSP00000109992	psi-mi:dkk3_mouse(display_long)|uniprotkb:Dkk3(gene name)|psi-mi:Dkk3(display_short)	psi-mi:q62406-1(display_long)|uniprotkb:Irak1(gene name)|psi-mi:Irak1(display_short)|uniprotkb:Il1rak(gene name synonym)|uniprotkb:Pelle-like protein kinase(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-657874	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	refseq:NP_056629.1|refseq:XP_006508076.1|go:"GO:0039706"(co-receptor binding)|go:"GO:0045892"(negative regulation of transcription, DNA-templated)|go:"GO:0048019"(receptor antagonist activity)|go:"GO:0090090"(negative regulation of canonical Wnt signaling pathway)|go:"GO:2000065"(negative regulation of cortisol biosynthetic process)|interpro:IPR006796(Dickkopf, N-terminal cysteine-rich)|interpro:IPR039863|ensembl:ENSMUSG00000030772(gene)|ensembl:ENSMUST00000033036(transcript)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0016055"(Wnt signaling pathway)|go:"GO:0032348"(negative regulation of aldosterone biosynthetic process)	intact:EBI-448533(irak1_mouse)|ensembl:ENSMUSG00000031392(gene)|ensembl:ENSMUST00000068286(transcript)|ensembl:ENSMUST00000114352(transcript)	afcs:14620(primary-reference)|afcs:18692(secondary-ac)	-	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:AjlEpRHm44Um/+UzjoILCN4IHNQ10090	rogid:f0/zWzQ/pwn4saHTcFh7pChaKIQ10090	intact-crc:BAEEF5AF71F5A453|rigid:jsH+V83+j4xuuhODCtppfHjMouc	false	sufficient binding region:157-296	sufficient binding region:433-710	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)
intact:EBI-687548	uniprotkb:P42227	-	intact:EBI-602878|uniprotkb:A2A5D1|uniprotkb:B7ZC17|ensembl:ENSMUSP00000120152	psi-mi:sec31l1_mouse_protei(display_short)|psi-mi:EBI-687548(display_long)	psi-mi:stat3_mouse(display_long)|uniprotkb:Acute-phase response factor(gene name synonym)|uniprotkb:Stat3(gene name)|psi-mi:Stat3(display_short)|uniprotkb:Aprf(gene name synonym)	psi-mi:"MI:0018"(two hybrid)	Papin et al. (2004)	pubmed:15102471	taxid:10090(mouse)|taxid:10090(Mus musculus)	taxid:10090(mouse)|taxid:10090(Mus musculus)	psi-mi:"MI:0915"(physical association)	psi-mi:"MI:0469"(IntAct)	intact:EBI-688535	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0498"(prey)	psi-mi:"MI:0496"(bait)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	afcs:40270(primary-reference)	refseq:NP_998824.1|refseq:NP_998825.1|dip:DIP-442N|ensembl:ENSMUSG00000004040(gene)|ensembl:ENSMUST00000127638(transcript)|go:"GO:0000785"(chromatin)|go:"GO:0000976"(transcription cis-regulatory region binding)|go:"GO:0000978"(RNA polymerase II cis-regulatory region sequence-specific DNA binding)|go:"GO:0000981"(DNA-binding transcription factor activity, RNA polymerase II-specific)|go:"GO:0001228"(DNA-binding transcription activator activity, RNA polymerase II-specific)|go:"GO:0001659"(temperature homeostasis)|go:"GO:0001754"(eye photoreceptor cell differentiation)|go:"GO:0003677"(DNA binding)|go:"GO:0003700"(DNA-binding transcription factor activity)|go:"GO:0004879"(nuclear receptor activity)|go:"GO:0005634"(nucleus)|go:"GO:0005654"(nucleoplasm)|go:"GO:0005667"(transcription regulator complex)|go:"GO:0005737"(cytoplasm)|go:"GO:0005739"(mitochondrion)|go:"GO:0005743"(mitochondrial inner membrane)|go:"GO:0005829"(cytosol)|go:"GO:0005886"(plasma membrane)|go:"GO:0006355"(regulation of transcription, DNA-templated)|go:"GO:0006357"(regulation of transcription by RNA polymerase II)|go:"GO:0006366"(transcription by RNA polymerase II)|go:"GO:0006606"(protein import into nucleus)|go:"GO:0006952"(defense response)|go:"GO:0006953"(acute-phase response)|go:"GO:0006954"(inflammatory response)|go:"GO:0007259"(receptor signaling pathway via JAK-STAT)|go:"GO:0007568"(aging)|go:"GO:0008134"(transcription factor binding)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0008285"(negative regulation of cell population proliferation)|go:"GO:0010507"(negative regulation of autophagy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010730"(negative regulation of hydrogen peroxide biosynthetic process)|go:"GO:0014069"(postsynaptic density)|go:"GO:0016310"(phosphorylation)|go:"GO:0019221"(cytokine-mediated signaling pathway)|go:"GO:0019827"(stem cell population maintenance)|go:"GO:0019901"(protein kinase binding)|go:"GO:0019903"(protein phosphatase binding)|go:"GO:0019953"(sexual reproduction)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0030522"(intracellular receptor signaling pathway)|go:"GO:0031490"(chromatin DNA binding)|go:"GO:0031730"(CCR5 chemokine receptor binding)|go:"GO:0032355"(response to estradiol)|go:"GO:0032731"(positive regulation of interleukin-1 beta production)|go:"GO:0032733"(positive regulation of interleukin-10 production)|go:"GO:0032755"(positive regulation of interleukin-6 production)|go:"GO:0032757"(positive regulation of interleukin-8 production)|go:"GO:0032760"(positive regulation of tumor necrosis factor production)|go:"GO:0032870"(cellular response to hormone stimulus)|go:"GO:0033210"(leptin-mediated signaling pathway)|go:"GO:0034097"(response to cytokine)|go:"GO:0035259"(glucocorticoid receptor binding)|go:"GO:0035591"(signaling adaptor activity)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042127"(regulation of cell population proliferation)|go:"GO:0042493"|go:"GO:0042593"(glucose homeostasis)|go:"GO:0042755"(eating behavior)|go:"GO:0042789"(mRNA transcription by RNA polymerase II)|go:"GO:0042802"(identical protein binding)|go:"GO:0042803"(protein homodimerization activity)|go:"GO:0043434"(response to peptide hormone)|go:"GO:0043565"(sequence-specific DNA binding)|go:"GO:0044320"(cellular response to leptin stimulus)|go:"GO:0044321"(response to leptin)|go:"GO:0045471"(response to ethanol)|go:"GO:0045648"(positive regulation of erythrocyte differentiation)|go:"GO:0045747"(positive regulation of Notch signaling pathway)|go:"GO:0045766"(positive regulation of angiogenesis)|go:"GO:0045820"(negative regulation of glycolytic process)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046902"(regulation of mitochondrial membrane permeability)|go:"GO:0046983"(protein dimerization activity)|go:"GO:0048708"(astrocyte differentiation)|go:"GO:0050804"(modulation of chemical synaptic transmission)|go:"GO:0051092"(positive regulation of NF-kappaB transcription factor activity)|go:"GO:0051726"(regulation of cell cycle)|go:"GO:0060019"(radial glial cell differentiation)|go:"GO:0060259"(regulation of feeding behavior)|go:"GO:0060396"(growth hormone receptor signaling pathway)|go:"GO:0060397"(growth hormone receptor signaling pathway via JAK-STAT)|go:"GO:0060548"(negative regulation of cell death)|go:"GO:0061629"(RNA polymerase II-specific DNA-binding transcription factor binding)|go:"GO:0070102"(interleukin-6-mediated signaling pathway)|go:"GO:0070878"(primary miRNA binding)|go:"GO:0071345"(cellular response to cytokine stimulus)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:0072538"(T-helper 17 type immune response)|go:"GO:0072540"(T-helper 17 cell lineage commitment)|go:"GO:0090575"(RNA polymerase II transcription regulator complex)|go:"GO:0097009"(energy homeostasis)|go:"GO:0098685"(Schaffer collateral - CA1 synapse)|go:"GO:0098978"(glutamatergic synapse)|go:"GO:0099527"(postsynapse to nucleus signaling pathway)|go:"GO:1900017"(positive regulation of cytokine production involved in inflammatory response)|go:"GO:1901215"(negative regulation of neuron death)|go:"GO:1902728"(positive regulation of growth factor dependent skeletal muscle satellite cell proliferation)|go:"GO:1902895"(positive regulation of miRNA transcription)|go:"GO:1904685"(positive regulation of metalloendopeptidase activity)|go:"GO:1905564"(positive regulation of vascular endothelial cell proliferation)|go:"GO:1905618"(positive regulation of miRNA-mediated gene silencing by inhibition of translation)|go:"GO:2000635"(negative regulation of primary miRNA processing)|go:"GO:2000637"(positive regulation of gene silencing by miRNA)|go:"GO:2000737"(negative regulation of stem cell differentiation)|go:"GO:2001171"(positive regulation of ATP biosynthetic process)|go:"GO:2001223"(negative regulation of neuron migration)|interpro:IPR000980(SH2 motif)|interpro:IPR001217(STAT transcription factor, core)|interpro:IPR008967(p53-like transcription factor, DNA-binding)|interpro:IPR012345(STAT transcription factor, DNA-binding, subdomain)|interpro:IPR013799(STAT transcription factor, protein interaction)|interpro:IPR013800(STAT transcription factor, all-alpha)|interpro:IPR013801(STAT transcription factor, DNA-binding)|interpro:IPR015988(STAT transcription factor, coiled coil)|interpro:IPR035855|interpro:IPR036535|interpro:IPR036860|mint:P42227|rcsb pdb:1BG1|rcsb pdb:3CWG|rcsb pdb:4E68|rcsb pdb:4ZIA|reactome:R-MMU-1059683|reactome:R-MMU-1266695|reactome:R-MMU-1433557|reactome:R-MMU-186763|reactome:R-MMU-6783783|reactome:R-MMU-6785807|reactome:R-MMU-8849474|reactome:R-MMU-8854691|reactome:R-MMU-8875791|reactome:R-MMU-8984722|reactome:R-MMU-8985947|reactome:R-MMU-9008059|reactome:R-MMU-9020933|reactome:R-MMU-9020956|reactome:R-MMU-9020958|reactome:R-MMU-8983432	afcs:6701(primary-reference)|afcs:40270(secondary-ac)	no-uniprot-update:An amino acid sequence which is not represented in UniProt|comment:AfCS Y2H protein. Translated from nucleotide sequence.|comment:"similar to human SEC31L1 protein (90%)."	-	dataset:Apoptosis - Interactions involving proteins with a function related to apoptosis|dataset:AFCS - Interactions from the Alliance for Cell Signaling database	taxid:4932(yeasx)|taxid:4932("Saccharomyces cerevisiae (Baker's yeast)")	-	2005/09/28	2014/10/16	rogid:KKcbi6CaFBl5ed3b0Y9sNstcTp010090	rogid:jWu9RTbZkTUtGrXQlg1K79zHowM10090	intact-crc:07041121951D258F|rigid:oSGwDvNgIdNgqOJ5Pj0WfKLYCVc	false	sufficient binding region:543-748	sufficient binding region:103-330	-	-	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)