#ID(s) interactor A ID(s) interactor B Alt. ID(s) interactor A Alt. ID(s) interactor B Alias(es) interactor A Alias(es) interactor B Interaction detection method(s) Publication 1st author(s) Publication Identifier(s) Taxid interactor A Taxid interactor B Interaction type(s) Source database(s) Interaction identifier(s) Confidence value(s) Expansion method(s) Biological role(s) interactor A Biological role(s) interactor B Experimental role(s) interactor A Experimental role(s) interactor B Type(s) interactor A Type(s) interactor B Xref(s) interactor A Xref(s) interactor B Interaction Xref(s) Annotation(s) interactor A Annotation(s) interactor B Interaction annotation(s) Host organism(s) Interaction parameter(s) Creation date Update date Checksum(s) interactor A Checksum(s) interactor B Interaction Checksum(s) Negative Feature(s) interactor A Feature(s) interactor B Stoichiometry(s) interactor A Stoichiometry(s) interactor B Identification method participant A Identification method participant B uniprotkb:P28067 uniprotkb:P28068 intact:EBI-3865396|uniprotkb:Q29639|uniprotkb:Q29640|ensembl:ENSP00000363976|ensembl:ENSP00000372717|ensembl:ENSP00000392842|ensembl:ENSP00000395349|ensembl:ENSP00000404018|ensembl:ENSP00000407198|ensembl:ENSP00000410591 intact:EBI-2877138|ensembl:ENSP00000372718|ensembl:ENSP00000378723|ensembl:ENSP00000393646|ensembl:ENSP00000398890|ensembl:ENSP00000408453|ensembl:ENSP00000411321|ensembl:ENSP00000413471|ensembl:ENSP00000414817|uniprotkb:Q13012|uniprotkb:Q5SNZ8|uniprotkb:Q58ZE2|uniprotkb:O77936|uniprotkb:Q29751|uniprotkb:Q5STC4|uniprotkb:Q9XRX2 psi-mi:dma_human(display_long)|uniprotkb:HLA-DMA(gene name)|psi-mi:HLA-DMA(display_short)|uniprotkb:DMA(gene name synonym)|uniprotkb:RING6(gene name synonym)|uniprotkb:MHC class II antigen DMA(gene name synonym)|uniprotkb:Really interesting new gene 6 protein(gene name synonym) psi-mi:dmb_human(display_long)|uniprotkb:HLA-DMB(gene name)|psi-mi:HLA-DMB(display_short)|uniprotkb:DMB(gene name synonym)|uniprotkb:RING7(gene name synonym)|uniprotkb:MHC class II antigen DMB(gene name synonym)|uniprotkb:Really interesting new gene 7 protein(gene name synonym) psi-mi:"MI:0114"(x-ray crystallography) Mosyak et al. (1998) pubmed:9768757|mint:MINT-6548257|imex:IM-27288 taxid:9606(human)|taxid:9606(Homo sapiens) taxid:9606(human)|taxid:9606(Homo sapiens) psi-mi:"MI:0407"(direct interaction) psi-mi:"MI:0471"(MINT) intact:EBI-8685430|wwpdb:1hdm|mint:MINT-24982|imex:IM-27288-1 - - psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0499"(unspecified role) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0497"(neutral component) psi-mi:"MI:0326"(protein) psi-mi:"MI:0326"(protein) ensembl:ENSG00000204257(gene)|ensembl:ENSG00000239463(gene)|ensembl:ENSG00000242361(gene)|ensembl:ENSG00000242685(gene)|ensembl:ENSG00000243189(gene)|ensembl:ENSG00000243215(gene)|ensembl:ENSG00000243719(gene)|ensembl:ENST00000374843(transcript)|ensembl:ENST00000383230(transcript)|ensembl:ENST00000434337(transcript)|ensembl:ENST00000441375(transcript)|ensembl:ENST00000450601(transcript)|ensembl:ENST00000452615(transcript)|ensembl:ENST00000453490(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0009986"(cell surface)|go:"GO:0016020"(membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|interpro:IPR001003(MHC class II, alpha chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|rcsb pdb:4GBX|reactome:R-HSA-2132295|dip:DIP-6184N|mint:MINT-1539829(identity) ensembl:ENSG00000242386(gene)|ensembl:ENSG00000242574(gene)|ensembl:ENST00000383231(transcript)|ensembl:ENST00000395312(transcript)|ensembl:ENST00000412948(transcript)|ensembl:ENST00000418107(transcript)|ensembl:ENST00000424822(transcript)|ensembl:ENST00000428420(transcript)|ensembl:ENST00000440078(transcript)|ensembl:ENST00000450897(transcript)|go:"GO:0002250"(adaptive immune response)|go:"GO:0002399"(MHC class II protein complex assembly)|go:"GO:0002503"(peptide antigen assembly with MHC class II protein complex)|go:"GO:0005765"(lysosomal membrane)|go:"GO:0016021"(integral component of membrane)|go:"GO:0023026"(MHC class II protein complex binding)|go:"GO:0031902"(late endosome membrane)|go:"GO:0042102"(positive regulation of T cell proliferation)|go:"GO:0042613"(MHC class II protein complex)|go:"GO:0043231"(intracellular membrane-bounded organelle)|go:"GO:2001190"(positive regulation of T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell)|interpro:IPR000353(MHC class II, beta chain, N-terminal)|interpro:IPR003006(Immunoglobulin/major histocompatibility complex, conserved site)|interpro:IPR003597(Immunoglobulin C1-set)|interpro:IPR007110(Immunoglobulin-like)|interpro:IPR011162(MHC classes I and II-like antigen recognition)|interpro:IPR013783(Immunoglobulin-like fold)|interpro:IPR014745(MHC class II, alpha/beta chain, N-terminal)|interpro:IPR036179|rcsb pdb:1HDM|rcsb pdb:2BC4|rcsb pdb:4FQX|go:"GO:0019886"(antigen processing and presentation of exogenous peptide antigen via MHC class II)|rcsb pdb:4GBX|rcsb pdb:4I0P|reactome:R-HSA-2132295|ensembl:ENSG00000226264(gene)|ensembl:ENSG00000234154(gene)|ensembl:ENSG00000239329(gene)|ensembl:ENSG00000241296(gene)|ensembl:ENSG00000241674(gene)|ensembl:ENSG00000242092(gene)|refseq:NP_002109.2|dip:DIP-6185N|mint:MINT-1539836(identity) - comment:"Stoichiometry: 1.0" comment:"Stoichiometry: 1.0" 3d-r-factors:19.4 working, 25.6 free|figure legend:Table 1|3d-resolution:2.50A|full coverage:Only protein-protein interactions|curation depth:imex curation taxid:-1(in vitro)|taxid:-1(In vitro) - 2004/02/12 2015/05/19 rogid:QjF0NtsdYPY9nPAdSitRy+bPNIU9606 rogid:8GCrK2bWQedv8/K7AZkbodpaQJc9606 intact-crc:3E958812B4CCD0CE|rigid:S+47sW9LWBU9MPWeiiGnEGXhlNg false flag tag:?-?(MINT-1539830)|sufficient binding region:27-230 tag:?-?(MINT-1539837)|sufficient binding region:19-218 1 1 psi-mi:"MI:0078"(nucleotide sequence identification) psi-mi:"MI:0078"(nucleotide sequence identification)