#ID(s) interactor A	ID(s) interactor B	Alt. ID(s) interactor A	Alt. ID(s) interactor B	Alias(es) interactor A	Alias(es) interactor B	Interaction detection method(s)	Publication 1st author(s)	Publication Identifier(s)	Taxid interactor A	Taxid interactor B	Interaction type(s)	Source database(s)	Interaction identifier(s)	Confidence value(s)	Expansion method(s)	Biological role(s) interactor A	Biological role(s) interactor B	Experimental role(s) interactor A	Experimental role(s) interactor B	Type(s) interactor A	Type(s) interactor B	Xref(s) interactor A	Xref(s) interactor B	Interaction Xref(s)	Annotation(s) interactor A	Annotation(s) interactor B	Interaction annotation(s)	Host organism(s)	Interaction parameter(s)	Creation date	Update date	Checksum(s) interactor A	Checksum(s) interactor B	Interaction Checksum(s)	Negative	Feature(s) interactor A	Feature(s) interactor B	Stoichiometry(s) interactor A	Stoichiometry(s) interactor B	Identification method participant A	Identification method participant B
uniprotkb:P24594	uniprotkb:P05019	intact:EBI-7902235|intact:MINT-204226|ensembl:ENSRNOP00000023530	intact:EBI-7902275|uniprotkb:Q14620|intact:MINT-6376445|uniprotkb:B2RWM7|uniprotkb:P01343|uniprotkb:E9PD02|intact:MINT-204184|ensembl:ENSP00000302665	psi-mi:ibp5_rat(display_long)|uniprotkb:Igfbp5(gene name)|psi-mi:Igfbp5(display_short)|uniprotkb:Igfbp-5(gene name synonym)	psi-mi:igf1_human(display_long)|uniprotkb:IGF1(gene name)|psi-mi:IGF1(display_short)|uniprotkb:IBP1(gene name synonym)|uniprotkb:Somatomedin-C(gene name synonym)|uniprotkb:Mechano growth factor(gene name synonym)	psi-mi:"MI:0114"(x-ray crystallography)	Zesławski et al. (2001)	pubmed:11447105|mint:MINT-5214254	taxid:10116(rat)|taxid:10116("Rattus norvegicus (Rat)")	taxid:9606(human)|taxid:9606(Homo sapiens)	psi-mi:"MI:0407"(direct interaction)	psi-mi:"MI:0471"(MINT)	intact:EBI-7902412|mint:MINT-24973	-	-	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0499"(unspecified role)	psi-mi:"MI:0326"(protein)	psi-mi:"MI:0326"(protein)	rgd:2876|refseq:NP_036949.1|ensembl:ENSRNOG00000017206(gene)|ensembl:ENSRNOT00000023530(transcript)|go:"GO:0001558"(regulation of cell growth)|go:"GO:0001649"(osteoblast differentiation)|go:"GO:0001968"(fibronectin binding)|go:"GO:0005520"(insulin-like growth factor binding)|go:"GO:0005615"(extracellular space)|go:"GO:0007565"(female pregnancy)|go:"GO:0007568"(aging)|go:"GO:0014912"(negative regulation of smooth muscle cell migration)|go:"GO:0017148"(negative regulation of translation)|go:"GO:0030336"(negative regulation of cell migration)|go:"GO:0031069"(hair follicle morphogenesis)|go:"GO:0031994"(insulin-like growth factor I binding)|go:"GO:0031995"(insulin-like growth factor II binding)|go:"GO:0035556"(intracellular signal transduction)|go:"GO:0040008"(regulation of growth)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0042593"(glucose homeostasis)|go:"GO:0043567"(regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0043569"(negative regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0044342"(type B pancreatic cell proliferation)|go:"GO:0045668"(negative regulation of osteoblast differentiation)|go:"GO:0045926"(negative regulation of growth)|go:"GO:0048286"(lung alveolus development)|go:"GO:0048662"(negative regulation of smooth muscle cell proliferation)|go:"GO:0051146"(striated muscle cell differentiation)|go:"GO:0051897"(positive regulation of protein kinase B signaling)|go:"GO:0060056"(mammary gland involution)|go:"GO:0060416"(response to growth hormone)|go:"GO:0071320"(cellular response to cAMP)|go:"GO:0071407"(cellular response to organic cyclic compound)|go:"GO:1901862"(negative regulation of muscle tissue development)|go:"GO:1904205"(negative regulation of skeletal muscle hypertrophy)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1904754"(positive regulation of vascular associated smooth muscle cell migration)|interpro:IPR000716(Thyroglobulin type-1)|interpro:IPR000867(Insulin-like growth factor-binding protein, IGFBP)|interpro:IPR009030(Growth factor, receptor)|interpro:IPR012213(Insulin-like growth factor binding protein 5)|interpro:IPR017891|interpro:IPR022321|interpro:IPR036857|reactome:R-RNO-381426|reactome:R-RNO-8957275|mint:MINT-580868(identity)	refseq:NP_001104755.1|refseq:NP_000609.1|refseq:NP_001104754.1|go:"GO:0001775"(cell activation)|go:"GO:0005158"(insulin receptor binding)|go:"GO:0005159"(insulin-like growth factor receptor binding)|go:"GO:0005178"(integrin binding)|go:"GO:0005179"(hormone activity)|go:"GO:0005576"(extracellular region)|go:"GO:0005615"(extracellular space)|go:"GO:0007165"(signal transduction)|go:"GO:0007265"(Ras protein signal transduction)|go:"GO:0007517"(muscle organ development)|go:"GO:0008083"(growth factor activity)|go:"GO:0008283"(cell population proliferation)|go:"GO:0008284"(positive regulation of cell population proliferation)|go:"GO:0009408"(response to heat)|go:"GO:0009441"(glycolate metabolic process)|go:"GO:0010468"(regulation of gene expression)|go:"GO:0010560"(positive regulation of glycoprotein biosynthetic process)|go:"GO:0010613"(positive regulation of cardiac muscle hypertrophy)|go:"GO:0010628"(positive regulation of gene expression)|go:"GO:0010629"(negative regulation of gene expression)|go:"GO:0014065"(phosphatidylinositol 3-kinase signaling)|go:"GO:0014068"(positive regulation of phosphatidylinositol 3-kinase signaling)|go:"GO:0014834"(skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration)|go:"GO:0014896"(muscle hypertrophy)|go:"GO:0014904"(myotube cell development)|go:"GO:0014911"(positive regulation of smooth muscle cell migration)|go:"GO:0016942"(insulin-like growth factor binding protein complex)|go:"GO:0030166"(proteoglycan biosynthetic process)|go:"GO:0030335"(positive regulation of cell migration)|go:"GO:0031093"(platelet alpha granule lumen)|go:"GO:0032148"(activation of protein kinase B activity)|go:"GO:0032691"(negative regulation of interleukin-1 beta production)|go:"GO:0032720"(negative regulation of tumor necrosis factor production)|go:"GO:0034392"(negative regulation of smooth muscle cell apoptotic process)|go:"GO:0035630"(bone mineralization involved in bone maturation)|go:"GO:0035867"(alphav-beta3 integrin-IGF-1-IGF1R complex)|go:"GO:0040014"(regulation of multicellular organism growth)|go:"GO:0042060"(wound healing)|go:"GO:0042104"(positive regulation of activated T cell proliferation)|go:"GO:0042531"(positive regulation of tyrosine phosphorylation of STAT protein)|go:"GO:0042567"(insulin-like growth factor ternary complex)|go:"GO:0043066"(negative regulation of apoptotic process)|go:"GO:0043388"(positive regulation of DNA binding)|go:"GO:0043410"(positive regulation of MAPK cascade)|go:"GO:0043491"(protein kinase B signaling)|go:"GO:0043568"(positive regulation of insulin-like growth factor receptor signaling pathway)|go:"GO:0045445"(myoblast differentiation)|go:"GO:0045669"(positive regulation of osteoblast differentiation)|go:"GO:0045725"(positive regulation of glycogen biosynthetic process)|go:"GO:0045821"(positive regulation of glycolytic process)|go:"GO:0045840"(positive regulation of mitotic nuclear division)|go:"GO:0045893"(positive regulation of transcription, DNA-templated)|go:"GO:0045944"(positive regulation of transcription by RNA polymerase II)|go:"GO:0046326"(positive regulation of glucose import)|go:"GO:0046579"(positive regulation of Ras protein signal transduction)|go:"GO:0048009"(insulin-like growth factor receptor signaling pathway)|go:"GO:0048015"(phosphatidylinositol-mediated signaling)|go:"GO:0048146"(positive regulation of fibroblast proliferation)|go:"GO:0048661"(positive regulation of smooth muscle cell proliferation)|go:"GO:0050679"(positive regulation of epithelial cell proliferation)|go:"GO:0050714"(positive regulation of protein secretion)|go:"GO:0050731"(positive regulation of peptidyl-tyrosine phosphorylation)|go:"GO:0050821"(protein stabilization)|go:"GO:0051450"(myoblast proliferation)|go:"GO:0060283"(negative regulation of oocyte development)|go:"GO:0061051"(positive regulation of cell growth involved in cardiac muscle cell development)|go:"GO:0070371"(ERK1 and ERK2 cascade)|go:"GO:0070382"(exocytic vesicle)|go:"GO:0070886"(positive regulation of calcineurin-NFAT signaling cascade)|go:"GO:0090201"(negative regulation of release of cytochrome c from mitochondria)|go:"GO:0150079"(negative regulation of neuroinflammatory response)|go:"GO:1902430"(negative regulation of amyloid-beta formation)|go:"GO:1904075"(positive regulation of trophectodermal cell proliferation)|go:"GO:1904646"(cellular response to amyloid-beta)|go:"GO:1904707"(positive regulation of vascular associated smooth muscle cell proliferation)|go:"GO:1905460"(negative regulation of vascular associated smooth muscle cell apoptotic process)|go:"GO:2000679"(positive regulation of transcription regulatory region DNA binding)|go:"GO:2001237"(negative regulation of extrinsic apoptotic signaling pathway)|interpro:IPR016179(Insulin-like)|interpro:IPR022341|interpro:IPR022350|interpro:IPR022352|interpro:IPR022353|interpro:IPR036438|rcsb pdb:1B9G|rcsb pdb:1BQT|rcsb pdb:1GF1|rcsb pdb:1GZR|ensembl:ENSG00000017427(gene)|ensembl:ENST00000307046(transcript)|go:"GO:0000187"(obsolete activation of MAPK activity)|go:"GO:0001501"(skeletal system development)|rcsb pdb:1GZY|rcsb pdb:1GZZ|rcsb pdb:1H02|rcsb pdb:1H59|rcsb pdb:1IMX|rcsb pdb:1PMX|rcsb pdb:1TGR|rcsb pdb:1WQJ|rcsb pdb:2DSP|rcsb pdb:2DSQ|rcsb pdb:2DSR|rcsb pdb:2GF1|rcsb pdb:3GF1|rcsb pdb:3LRI|rcsb pdb:4XSS|rcsb pdb:5U8Q|rcsb pdb:6FF3|rcsb pdb:6PYH|rcsb pdb:6RVA|reactome:R-HSA-114608|reactome:R-HSA-2404192|reactome:R-HSA-2428928|reactome:R-HSA-2428933|reactome:R-HSA-381426|reactome:R-HSA-422085|dip:DIP-41933N|dip:DIP-6021N|mint:MINT-580861(identity)	-	comment:mint|function:IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors|comment:"Stoichiometry: 1.0"	function:The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity|function:"Defects in IGF1 are the cause of insulin-like growth factor I deficiency (IGF1 deficiency) [MIM:608747]. IGF1 deficiency is an autosomal recessive disorder characterized by growth retardation, sensorineural deafness and mental retardation"|comment:mint|comment:"Stoichiometry: 1.0"	comment:In the xray complex 1h59, P05019 is chain A and P24594 is chain B Resolution 2.100|comment:homomint|comment:mint	taxid:-1(in vitro)|taxid:-1(In vitro)	-	2004/02/12	2014/10/16	rogid:Ld5ONaGvIuuHZx1uSOEm8JVSAMg10116	rogid:aZEsGQKF+moxGu7jxbhfvGucyTA9606	intact-crc:956CCADC87505E9E|rigid:a/FdU3Rmq8YFZYxXT3BsooFpQII	false	tag:?-?(MINT-580869)	tag:?-?(MINT-580862)	1	1	psi-mi:"MI:0078"(nucleotide sequence identification)	psi-mi:"MI:0078"(nucleotide sequence identification)