IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Long noncoding RNA NEAT1 promotes tumorigenesis in H. pylori gastric cancer by sponging miR-30a to regulate COX-2/BCL9 pathway. Long noncoding RNA NEAT1 promotes tumorigenesis in H. pylori gastric cancer by sponging miR-30a to regulate COX-2/BCL9 pathway. Helicobacter 2021 imex curation Rao X., Liu X., Liu N., Zhang Y., Zhang Z., Zhou L., Han G., Cen R., Shi N., Zhu H., Gong H., Huang C., Ji Q., Li Q. ttt99118@hotmail.com Only protein-protein interactions imex curation human-mkn45 Homo sapiens gastric adenocarcinoma cell line MKN45 mkn45 Human gastric adenocarcinoma cell line MKN45 mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag luciferase tag visualisation by luciferase assay tag luciferase Rao X., Liu X., Liu N., Zhang Y., Zhang Z., Zhou L., Han G., Cen R., Shi N., Zhu H., Gong H., Huang C., Ji Q., Li Q. ttt99118@hotmail.com Accepted 2021-OCT-20 AT 07:59 BST AT 07:59 BST by MGT Helicobacter 2021 Only protein-protein interactions imex curation imex curation Long noncoding RNA NEAT1 promotes tumorigenesis in H. pylori gastric cancer by sponging miR-30a to regulate COX-2/BCL9 pathway. Long noncoding RNA NEAT1 promotes tumorigenesis in H. pylori gastric cancer by sponging miR-30a to regulate COX-2/BCL9 pathway. Helicobacter 2021 imex curation Rao X., Liu X., Liu N., Zhang Y., Zhang Z., Zhou L., Han G., Cen R., Shi N., Zhu H., Gong H., Huang C., Ji Q., Li Q. ttt99118@hotmail.com Only protein-protein interactions imex curation human-sgc7901 SGC7901-Human gastric cancer cell line, from metastatic lymphnode. sgc7901 SGC7901-Human gastric cancer cell line, from metastatic lymphnode. mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag luciferase tag visualisation by luciferase assay tag luciferase Rao X., Liu X., Liu N., Zhang Y., Zhang Z., Zhou L., Han G., Cen R., Shi N., Zhu H., Gong H., Huang C., Ji Q., Li Q. ttt99118@hotmail.com Accepted 2021-OCT-20 AT 07:59 BST AT 07:59 BST by MGT Helicobacter 2021 Only protein-protein interactions imex curation imex curation hsa-mir-30a-3p mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA human Homo sapiens Human CUUUCAGUCGGAUGUUUGCAGC lncrn_neat1 human short Homo sapiens nuclear paraspeckle assembly transcript 1 (NEAT1) short isoform lncrna long non-coding ribonucleic acid lncRNA long non coding RNA long non coding ribonucleic acid long non-coding RNA lncrna human Homo sapiens Human GGAGUUAGCGACAGGGAGGGAUGCGCGCCUGGGUGUAGUUGUGGGGGAGGAAGUGGCUAGCUCAGGGCUUCAGGGGACAGACAGGGAGAGAUGACUGAGUUAGAUGAGACGAGGGGGCGGGCUGGGGGUGCGAGAAGGAAGCUUGGCAAGGAGACUAGGUCUAGGGGGACCACAGUGGGGCAGGCUGCAUGGAAAAUAUCCGCAGGGUCCCCCAGGCAGAACAGCCACGCUCCAGGCCAGGCUGUCCCUACUGCCUGGUGGAGGGGGAACUUGACCUCUGGGAGGGCGCCGCUCUUGCAUAGCUGAGCGAGCCCGGGUGCGCUGGUCUGUGUGGAAGGAGGAAGGCAGGGAGAGGUAGAAGGGGUGGAGGAGUCAGGAGGAAUAGGCCGCAGCAGCCCUGGAAAUGAUCAGGAAGGCAGGCAGUGGGUGCAGGGCUGCAGGAGGGCCGGGAGGGCUAAUCUUCAACUUGUCCAUGCCAGCAGCCCCUUUUUUUCCAGACCAAGGGCUGUGAACCCGCCUGGGGAUGAGGCCUGGUCUUGUGGAACUGAACUUAGCUCGACGGGGCUGACCGCUCUGGCCCAGGGUGGUAUGUAAUUUUCGCUCGGCCUGGGACGGGGCCCAGGCCGGGCCCAGCCUGGUGGAGCGUCCAGGUCUGGGUGCGAAGCCAGGCCCCUGGGCGGAGGUGAGGGGUGGUCUGAGGAGUGAUGUGGAGUUAAGGCGCCAUCCUCACCGGUGACUGGUGCGGCACCUAGCAUGUUUGACAGGCGGGGACUGCGAGGCACGCUGCUCGGGUGUUGGGGACAACAUUGACCAACGCUUUAUUUUCCAGGUGGCAGUGCUCCUUUUGGACUUUUCUCUAGGUUUGGCGCUAAACUCUUCUUGUGAGCUCACUCCACCCCUUCUUCCUCCCUUUAACUUAUCCAUUCACUUAAAACAUUACCUGGUCAUCUGGUAAGCCCGGGACAGUAAGCCGAGUGGCUGUUGGAGUCGGUAUUGUUGGUAAUGGUGGAGGAAGAGAGGCCUUCCCGCUGAGGCUGGGGUGGGGCGGAUCGGUGUUGCUUGCCUGCAGAGAGGGUGGGGAGUGAAUGUGCACCCUUGGGUGGGCCUGCAGCCAUCCAGCUGAAAGUUACAAAAAUGCUUCAUGGACCGUGGUUUGUUACUAUAGUGUUCCUCAUGGCGAGCAGAUGGAACCGGGAGACAUGGAGUCCCUGGCCAGUGUGAGUCCUAGCAUUGCAGGAGGGGAGACCCUGGAGGAGAGAGCCCGCCUCAAUUGAUGCCUGCAGAUUGAAUUUCCAGAGGCUUAGGAGGAGGAAGUUCUCCAAUGUUCUGUUUCCAGGCCUUGCUCAGGAAGCCCUGUAUUCAGGAGGCUACCAUUUAAAGUUUGCAGAUGAGCUUAUGGGGGGCAAUCUUAAAAAGUCCACAGCAGAUGCAUCCGGCUCGAGGGGCCAUCAGCUUUGAAUAAAUGCUUGUUCCAGAGCCCAUGAAUGCCAGCAGGCACCCCUCCUUUCCUGGGGUAAAGGUUUUCAGAUGCUGCAUCUUCUAAAUUGAGCCUCCGGUCAUACUAGUUUUGUGCUUGGAACCUUGCUUCAAGAAGAUCCCUAAGCUGUAGAACAUUUUAACGUUGAUGCCACAACGCAGAUUGAUGCCUUGUAGAUGGAGCUUGCAGAUGGAGCCCCGUGACCUCUCACCUACCCACCUGUUUGCCUGCCUUCUUGUGCGUUUCUCGGAGAAGUUCUUAGCCUGAUGAAAUAACUUGGGGCGUUGAAGAGCUGUUUAAUUUUAAAUGCCUUAGACUGGGGAUAUAUUAGAGGAAGCAGAUUGUCAAAUUAAGGGUGUCAUUGUGUUGUGCUAAACGCUGGGAGGGUACAAGUUGGUCAUUCCUAAAUCUGUGUGUGAGAAAUGGCAGGUCUAGUUUGGGCAUUGUGAUUGCAUUGCAGAUUACUAGGAGAAGGGAAUGGUGGGUACACCGGUAGUGCUCUUUUGUUCUUGCUUCGUUUUUUUAAACUUGAACUUUACUUCGUUAGAUUUCAUAAUACUUUCUUGGCAUUCUAGUAAGAGGACCCUGAGGUGGGAGUUGUGGGGGACGGGGAGAAGGGGACAGCUUGGCACCGGUCCCGUGGGCGUUGCAGUGUGGGGGAUGGGGGUAUGCAGCUUGGCACUGGUACUGGGAGGGAUGAGGGUGAAGAAGGGGAGAGGGUUGGUUAGAGAUACAGUGUGGGUGGUGGGGGUGGUAGGAAAUGCAGGUUGAAGGGAAUUCUCUGGGGCUUUGGGGAAUUUAGUGCGUGGGUGAGCCAAGAAAAUACUAAUUAAUAAUAGUAAGUUGUUAGUGUUGGUUAAGUUGUUGCUUGGAAGUGAGAAGUUGCUUAGAAACUUUCCAAAGUGCUUAGAACUUUAAGUGCAAACAGACAAACUAACAAACAAAAAUUGUUUUGCUUUGCUACAAGGUGGGGAAGACUGAAGAAGUGUUAACUGAAAACAGGUGACACAGAGUCACCAGUUUUCCGAGAACCAAAGGGAGGGGUGUGUGAUGCCAUCUCACAGGCAGGGGAAAUGUCUUUACCAGCUUCCUCCUGGUGGCCAAGACAGCCUGUUUCAGAGGGUUGUUUUGUUUGGGGUGUGGGUGUUAUCAAGUGAAUUAGUCACUUGAAAGAUGGGCGUCAGACUUGCAUACGCAGCAGAUCAGCAUCCUUCGCUGCCCCUUAGCAACUUAGGUGGUUGAUUUGAAACUGUGAAGGUGUGAUUUUUUCAGGAGCUGGAAGUCUUAGAAAAGCCUUGUAAAUGCCUAUAUUGUGGGCUUUUAACGUAUUUAAGGGACCACUUAAGACGAGAUUAGAUGGGCUCUUCUGGAUUUGUUCCUCAUUUGUCACAGGUGUCUUGUGAUUGAAAAUCAUGAGCGAAGUGAAAUUGCAUUGAAUUUCAAGGGAAUUUAGUAUGUAAAUCGUGCCUUAGAAACACAUCUGUUGUCUUUUCUGUGUUUGGUCGAUAUUAAUAAUGGCAAAAUUUUUGCCUAUCUAGUAUCUUCAAAUUGUAGUCUUUGUAACAACCAAAUAACCUUUUGUGGUCACUGUAAAAUUAAUAUUUGGUAGACAGAAUCCAUGUACCUUUGCUAAGGUUAGAAUGAAUAAUUUAUUGUAUUUUUAAUUUGAAUGUUUGUGCUUUUUAAAUGAGCCAAGACUAGAGGGGAAACUAUCACCUAAAAUCAGUUUGGAAAACAAGACCUAAAAAGGGAAGGGGAUGGGGAUUGUGGGGAGAGAGUGGGCGAGGUGCCUUUACUACAUGUGUGAUCUGAAAACCCUGCUUGGUUCUGAGCUGCGUCUAUUGAAUUGGUAAAGUAAUACCAAUGGCUUUUUAUCAUUUCCUUCUUCCCUUUAAGUUUCACUUGAAAUUUUAAAAAUCAUGGUUAUUUUUAUCGUUGGGAUCUUUCUGUCUUCUGGGUUCCAUUUUUUAAAUGUUUAAAAAUAUGUUGACAUGGUAGUUCAGUUCUUAACCAAUGACUUGGGGAUGAUGCAAACAAUUACUGUCGUUGGGAUUUAGAGUGUAUUAGUCACGCAUGUAUGGGGAAGUAGUCUCGGGUAUGCUGUUGUGAAAUUGAAACUGUAAAAGUAGAUGGUUGAAAGUACUGGUAUGUUGCUCUGUAUGGUAAGAACUAAUUCUGUUACGUCAUGUACAUAAUUACUAAUCACUUUUCUUCCCCUUUACAGCACAAAUAAAGUUUGAGUUCUAAACUCAUUAGAAAAAAAAAAAAAAAAAAAAAAA hsa-mir-30a-5p mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA human Homo sapiens Human UGUAAACAUCCUCGACUGGAAG hsa_mir_30a_3p-lncrn_neat1 human short-1 1 3 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator target regulator target regulator target modulator target neutral component neutral component engineered engineered purified purified 4 regulator regulator modulator regulator neutral component neutral component URS000075DAEC_9606:r.1106_1126delinsAGUACUAACGAACUAGUCCCU mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain CUGCAGCCAUCCAGCUGAAAG AGUACUAACGAACUAGUCCCU tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range physical association physical association FIG 3 A C down-regulates quantity hsa_mir_30a_5p-lncrn_neat1 human short-1 1 5 regulator target regulator target regulator target modulator target neutral component neutral component engineered engineered purified purified 4 regulator regulator modulator regulator neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range URS000075DAEC_9606:r.3449-3455delinscgugggc mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain AUGUUUA CGUGGGC physical association physical association FIG 3 B C down-regulates quantity hsa_mir_30a_3p-lncrn_neat1 human short-2 2 3 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator target regulator target regulator target modulator target neutral component neutral component engineered engineered purified purified 4 regulator regulator modulator regulator neutral component neutral component URS000075DAEC_9606:r.1106_1126delinsAGUACUAACGAACUAGUCCCU mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain CUGCAGCCAUCCAGCUGAAAG AGUACUAACGAACUAGUCCCU tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range physical association physical association FIG 3 A C down-regulates quantity hsa_mir_30a_5p-lncrn_neat1 human short-2 2 5 regulator target regulator target regulator target modulator target neutral component neutral component engineered engineered purified purified 4 regulator regulator modulator regulator neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range URS000075DAEC_9606:r.3449-3455delinscgugggc mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain AUGUUUA CGUGGGC physical association physical association FIG 3 B C down-regulates quantity