IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia. A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia. Journal of biochemistry 2019 imex curation Kakuda K., Niwa A., Honda R., Yamaguchi KI., Tomita H., Nojebuzzaman M., Hara A., Goto Y., Osawa M., Kuwata K. Rare diseases - Interactions investigated in the context of Rare genetic disease kuwata@gifu-u.ac.jp Only protein-protein interactions imex curation in vitro In vitro aggregation aggregation assay aggregation predetermined predetermined participant predetermined Kakuda K., Niwa A., Honda R., Yamaguchi KI., Tomita H., Nojebuzzaman M., Hara A., Goto Y., Osawa M., Kuwata K. Rare diseases - Interactions investigated in the context of Rare genetic disease kuwata@gifu-u.ac.jp Accepted 2021-SEP-06 AT 08:44 BST AT 08:44 BST by MGT Journal of biochemistry 2019 Only protein-protein interactions imex curation imex curation A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia. A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia. Journal of biochemistry 2019 imex curation Kakuda K., Niwa A., Honda R., Yamaguchi KI., Tomita H., Nojebuzzaman M., Hara A., Goto Y., Osawa M., Kuwata K. Rare diseases - Interactions investigated in the context of Rare genetic disease kuwata@gifu-u.ac.jp Only protein-protein interactions imex curation in vitro In vitro solution sedimentati cosedimentation in solution solution sedimentati predetermined predetermined participant predetermined Kakuda K., Niwa A., Honda R., Yamaguchi KI., Tomita H., Nojebuzzaman M., Hara A., Goto Y., Osawa M., Kuwata K. Rare diseases - Interactions investigated in the context of Rare genetic disease kuwata@gifu-u.ac.jp Accepted 2021-SEP-06 AT 08:44 BST AT 08:44 BST by MGT Journal of biochemistry 2019 Only protein-protein interactions imex curation imex curation A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia. A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia. Journal of biochemistry 2019 imex curation Kakuda K., Niwa A., Honda R., Yamaguchi KI., Tomita H., Nojebuzzaman M., Hara A., Goto Y., Osawa M., Kuwata K. Rare diseases - Interactions investigated in the context of Rare genetic disease kuwata@gifu-u.ac.jp Only protein-protein interactions imex curation in vitro In vitro dls dynamic light scattering dls predetermined predetermined participant predetermined Kakuda K., Niwa A., Honda R., Yamaguchi KI., Tomita H., Nojebuzzaman M., Hara A., Goto Y., Osawa M., Kuwata K. Rare diseases - Interactions investigated in the context of Rare genetic disease kuwata@gifu-u.ac.jp Accepted 2021-SEP-06 AT 08:44 BST AT 08:44 BST by MGT Journal of biochemistry 2019 Only protein-protein interactions imex curation imex curation A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia. A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia. Journal of biochemistry 2019 imex curation Kakuda K., Niwa A., Honda R., Yamaguchi KI., Tomita H., Nojebuzzaman M., Hara A., Goto Y., Osawa M., Kuwata K. Rare diseases - Interactions investigated in the context of Rare genetic disease kuwata@gifu-u.ac.jp Only protein-protein interactions imex curation in vitro In vitro atomic force microsc atomic force microscopy AFM AFM atomic force microsc predetermined predetermined participant predetermined Kakuda K., Niwa A., Honda R., Yamaguchi KI., Tomita H., Nojebuzzaman M., Hara A., Goto Y., Osawa M., Kuwata K. Rare diseases - Interactions investigated in the context of Rare genetic disease kuwata@gifu-u.ac.jp Accepted 2021-SEP-06 AT 08:44 BST AT 08:44 BST by MGT Journal of biochemistry 2019 Only protein-protein interactions imex curation imex curation disc1_mouse Disrupted in schizophrenia 1 homolog Disc1 protein protein mouse Mus musculus Mouse MQGGGPRGAPIHSPSHGADSGHGLPPAVAPQRRRLTRRPGYMRSTAGSGIGFLSPAVGMPHPSSAGLTGQQSQHSQSKAGQCGLDPGSHCQASLVGKPFLKSSLVPAVASEGHLHPAQRSMRKRPVHFAVHSKNDSRQSERLTGSFKPGDSGFWQELLSSDSFKSLAPSLDAPWNKGSRGLKTVKPLASPALNGPADIASLPGFQDTFTSSFSFIQLSLGAAGERGEAEGCLPSREAEPLHQRPQEMAAEASSSDRPHGDPRHLWTFSLHAAPGLADLAQVTRSSSRQSECGTVSSSSSDTGFSSQDASSAGGRGDQGGGWADAHGWHTLLREWEPMLQDYLLSNRRQLEVTSLILKLQKCQEKVVEDGDYDTAETLRQRLEELEQEKGRLSWALPSQQPALRSFLGYLAAQIQVALHGATQRAGSDDPEAPLEGQLRTTAQDSLPASITRRDWLIREKQRLQKEIEALQARMSALEAKEKRLSQELEEQEVLLRWPGCDLMALVAQMSPGQLQEVSKALGETLTSANQAPFQVEPPETLRSLRERTKSLNLAVRELTAQVCSGEKLCSSLRRRLSDLDTRLPALLEAKMLALSGSCFSTAKELTEEIWALSSEREGLEMFLGRLLALSSRNSRRLGIVKEDHLRCRQDLALQDAAHKTRMKANTVKCMEVLEGQLSSCRCPLLGRVWKADLETCQLLMQSLQLQEAGSSPHAEDEEQVHSTGEAAQTAALAVPRTPHPEEEKSPLQVLQEWDTHSALSPHCAAGPWKEDSHIVSAEVGEKCEAIGVKLLHLEDQLLGAMYSHDEALFQSLQGELQTVKETLQAMILQLQPTKEAGEASASYPTAGAQETEA B55A850B15028E6F disc1_human Disrupted in schizophrenia 1 protein DISC1 KIAA0457 protein protein human Homo sapiens Human MPGGGPQGAPAAAGGGGVSHRAGSRDCLPPAACFRRRRLARRPGYMRSSTGPGIGFLSPAVGTLFRFPGGVSGEESHHSESRARQCGLDSRGLLVRSPVSKSAAAPTVTSVRGTSAHFGIQLRGGTRLPDRLSWPCGPGSAGWQQEFAAMDSSETLDASWEAACSDGARRVRAAGSLPSAELSSNSCSPGCGPEVPPTPPGSHSAFTSSFSFIRLSLGSAGERGEAEGCPPSREAESHCQSPQEMGAKAASLDGPHEDPRCLSRPFSLLATRVSADLAQAARNSSRPERDMHSLPDMDPGSSSSLDPSLAGCGGDGSSGSGDAHSWDTLLRKWEPVLRDCLLRNRRQMEVISLRLKLQKLQEDAVENDDYDKAETLQQRLEDLEQEKISLHFQLPSRQPALSSFLGHLAAQVQAALRRGATQQASGDDTHTPLRMEPRLLEPTAQDSLHVSITRRDWLLQEKQQLQKEIEALQARMFVLEAKDQQLRREIEEQEQQLQWQGCDLTPLVGQLSLGQLQEVSKALQDTLASAGQIPFHAEPPETIRSLQERIKSLNLSLKEITTKVCMSEKFCSTLRKKVNDIETQLPALLEAKMHAISGNHFWTAKDLTEEIRSLTSEREGLEGLLSKLLVLSSRNVKKLGSVKEDYNRLRREVEHQETAYETSVKENTMKYMETLKNKLCSCKCPLLGKVWEADLEACRLLIQSLQLQEARGSLSVEDERQMDDLEGAAPPIPPRLHSEDKRKTPLKVLEEWKTHLIPSLHCAGGEQKEESYILSAELGEKCEDIGKKLLYLEDQLHTAIHSHDEDLIQSLRRELQMVKETLQAMILQLQPAKEAGEREAAASCMTAGVHEAQA 63C3FDF2F59830C6 disc1-disc1-1 3 6 unspecified role unspecified role neutral component neutral component purified purified binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9NRI5:p.Leu607Phe mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L F ecoli Escherichia coli (strain K12) 6 unspecified role unspecified role neutral component neutral component purified purified binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9NRI5:p.Leu607Phe mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L F ecoli Escherichia coli (strain K12) direct interaction direct interaction 2g-h 150 mM NaCl (CHEBI:26710) disc1-disc1-2 2 6 unspecified role unspecified role neutral component neutral component purified purified binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9NRI5:p.Leu607Phe mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L F ecoli Escherichia coli (strain K12) 6 unspecified role unspecified role neutral component neutral component purified purified binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9NRI5:p.Leu607Phe mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain L F ecoli Escherichia coli (strain K12) direct interaction direct interaction 2e-f 150 mM NaCl (CHEBI:26710) disc1-1 4 6 unspecified role unspecified role neutral component neutral component purified purified binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9NRI5:p.Leu607Phe mutation causing mutation causing an interaction mutation enabling interaction mutation causing mutation causing an interaction certain certain sequence position certain certain certain sequence position certain L F ecoli Escherichia coli (strain K12) direct interaction direct interaction 3f, SF 3E/F disc1-11 4 5 unspecified role unspecified role neutral component neutral component purified purified Q811T9:p.Leu604Phe mutation causing mutation causing an interaction mutation enabling interaction mutation causing mutation causing an interaction certain certain sequence position certain certain certain sequence position certain L F binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) direct interaction direct interaction 4d-e-f disc1-12 4 5 unspecified role unspecified role neutral component neutral component purified purified Q811T9:p.Leu604Phe mutation causing mutation causing an interaction mutation enabling interaction mutation causing mutation causing an interaction certain certain sequence position certain certain certain sequence position certain L F binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecoli Escherichia coli (strain K12) direct interaction direct interaction 4d-e-f,SF4 E/F disc1-disc1-3 1 6 unspecified role unspecified role neutral component neutral component purified purified binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9NRI5:p.Leu607Phe mutation increasing mutation increasing interaction mutation increasing certain certain sequence position certain certain certain sequence position certain L F ecoli Escherichia coli (strain K12) 6 unspecified role unspecified role neutral component neutral component purified purified binding region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Q9NRI5:p.Leu607Phe mutation increasing mutation increasing interaction mutation increasing certain certain sequence position certain certain certain sequence position certain L F ecoli Escherichia coli (strain K12) direct interaction direct interaction 5a-b