DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A lower X-gate in TASK channels traps inhibitors within the vestibule. A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature 2020 imex curation Rödström KEJ., Kiper AK., Zhang W., Rinné S., Pike ACW., Goldstein M., Conrad LJ., Delbeck M., Hahn MG., Meier H., Platzk M., Quigley A., Speedman D., Shrestha L., Mukhopadhyay SMM., Burgess-Brown NA., Tucker SJ., Müller T., Decher N., Carpenter EP. decher@staff.uni-marburg.de, liz.carpenter@sgc.ox.ac.uk 28-Sep-2020: Contacted by IntAct-Help. Only protein-protein interactions imex curation spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction experimental particp experimental participant identification experimental particp Rödström KEJ., Kiper AK., Zhang W., Rinné S., Pike ACW., Goldstein M., Conrad LJ., Delbeck M., Hahn MG., Meier H., Platzk M., Quigley A., Speedman D., Shrestha L., Mukhopadhyay SMM., Burgess-Brown NA., Tucker SJ., Müller T., Decher N., Carpenter EP. decher@staff.uni-marburg.de, liz.carpenter@sgc.ox.ac.uk Accepted 2020-SEP-03 AT 11:35 BST AT 11:35 BST by ORCHARD Nature 2020 Only protein-protein interactions imex curation imex curation kcnk3_human Potassium channel subfamily K member 3 KCNK3 TASK TASK1 Acid-sensitive potassium channel protein TASK-1 TWIK-related acid-sensitive K(+) channel 1 Two pore potassium channel KT3.1 protein protein human Homo sapiens Human MKRQNVRTLALIVCTFTYLLVGAAVFDALESEPELIERQRLELRQQELRARYNLSQGGYEELERVVLRLKPHKAGVQWRFAGSFYFAITVITTIGYGHAAPSTDGGKVFCMFYALLGIPLTLVMFQSLGERINTLVRYLLHRAKKGLGMRRADVSMANMVLIGFFSCISTLCIGAAAFSHYEHWTFFQAYYYCFITLTTIGFGDYVALQKDQALQTQPQYVAFSFVYILTGLTVIGAFLNLVVLRFMTMNAEDEKRDAEHRALLTRNGQAGGGGGGGSAHTTDTASSTAAAGGGGFRNVYAEVLHFQSMCSCLWYKSREKLQYSIPMIIPRDLSTSDTCVEQSHSSPGGGGRYSDTPSRRCLCSGAPRSAISSVSTGLHSLSTFRGLMKRRSSV mint pH-dependent, voltage-insensitive, background potassium channel protein. Rectification direction results from potassium ion concentration on either side of the membrane. Acts as an outward rectifier when external potassium concentration is low. When external potassium concentration is high, current is inward 9FF4C8266F615FB7 kcnk3-1 1 2 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed 1-259 binding region 1-259 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain spofr-sf_9 Spodoptera frugiperda insect cells Fall armyworm sf_9 insect cells Derived from pupal ovarian tissue of the fall armyworm Cloned from the parent cell line, IPLB-SF-21-AE (SF-21) derived from immature ovaries of fall armyworm Spodoptera frugiperda pupae cells are susceptible to Baculovirus infection direct interaction direct interaction Fig 1, Ext Data Tab 1