DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Structure of ATP citrate lyase and the origin of citrate synthase in the Krebs cycle. Nature 2019 imex curation Verschueren KHG., Blanchet C., Felix J., Dansercoer A., De Vos D., Bloch Y., Van Beeumen J., Svergun D., Gutsche I., Savvides SN., Verstraete K. kenneth.verstraete@ugent.be 04-05-20: Contacted by IntAct-Help. Only protein-protein interactions imex curation human Homo sapiens Human x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Verschueren KHG., Blanchet C., Felix J., Dansercoer A., De Vos D., Bloch Y., Van Beeumen J., Svergun D., Gutsche I., Savvides SN., Verstraete K. kenneth.verstraete@ugent.be Accepted 2020-APR-28 AT 05:49 BST AT 05:49 BST by KALPANAP Nature 2019 Only protein-protein interactions imex curation imex curation q75vx1_hydth Citrate synthase (unknown stereospecificity) ccl protein protein Hydrogenobacter thermophilus Hydrogenobacter thermophilus MERIWKTGITQHIGHETYIRGYRLLDLVGNLSFAQAIYLILKGELPTERESRMMEAMLVSVIDHGIAPPSAIAARSVASGGNSLNVGVAAGVLAFGSAHGGALEDAMRFIQEGVSSKRSVEDIVKEYLETKKPIPGYGHRYYKDFDPRTKRLMDIARVLEFYGEHCKFAEDVAEEIGRQKGKKLVLNVDGAIAAIASEMGFDWRLGKGFFIIGRVPGLVAHVYEELTTEKPFSKRLDEERDVEYTGSPPRELPQELKKI F0CD4A24934FEAAF a0a0w8fb26_9zzzz ATP citrate synthase ASZ90_012237 protein protein hydrocarbon metagenome hydrocarbon metagenome MAQRGIREYDAKNLLARYLPEYLDDFSYKGNLALVGPETDIEGLEAENPWLKTTRLVVKPDQLFGKRGKLGLVLLDADWEEAKEYLNEKMGLEVTIGGITGRLSYFLIEPFTPHKEEYYVAISSDYEGDNIFFSMDGGVGVEENWEKVISIHVDSLEGIDALDVGSKLPAELGDKRALVEEFITALWRFYSDTGFAYVEINPFTFSGRGIVPLDMVAKLDDAEEYWQKKRWSELAFPEPFGRTPSKEELFIKEIDSKTGASLKLTILNPEGRVWTMVAGGGASVIYADTICDLGHADEMANYGEYSGDPNTEETYHYTCTILDLMTRSKNPNGKVLLIGGAIANFTDVAKTFKGVVMALEEYQQKLQEADIEIYVRRGGPNYEQGLKLMRDLGKRLGVPIQVHGPETHMTRIVPLALEENQ A2AEF118DB84CE1C p53396-2 ATP-citrate synthase ATP-citrate (pro-S-)-lyase Citrate cleavage enzyme ACLY protein protein human Homo sapiens Human MSAKAISEQTGKELLYKFICTTSAIQNRFKYARVTPDTDWARLLQDHPWLLSQNLVVKPDQLIKRRGKLGLVGVNLTLDGVKSWLKPRLGQEATVGKATGFLKNFLIEPFVPHSQAEEFYVCIYATREGDYVLFHHEGGVDVGDVDAKAQKLLVGVDEKLNPEDIKKHLLVHAPEDKKEILASFISGLFNFYEDLYFTYLEINPLVVTKDGVYVLDLAAKVDATADYICKVKWGDIEFPPPFGREAYPEEAYIADLDAKSGASLKLTLLNPKGRIWTMVAGGGASVVYSDTICDLGGVNELANYGEYSGAPSEQQTYDYAKTILSLMTREKHPDGKILIIGGSIANFTNVAATFKGIVRAIRDYQGPLKEHEVTIFVRRGGPNYQEGLRVMGEVGKTTGIPIHVFGTETHMTAIVGMALGHRPIPNQPPTAAHTANFLLNASGSTSTPAPSRTASFSESRADEVAPAKKAKPAMPQGKSTTLFSRHTKAIVWGMQTRAVQGMLDFDYVCSRDEPSVAAMVYPFTGDHKQKFYWGHKEILIPVFKNMADAMRKHPEVDVLINFASLRSAYDSTMETMNYAQIRTIAIIAEGIPEALTRKLIKKADQKGVTIIGPATVGGIKPGCFKIGNTGGMLDNILASKLYRPGSVAYVSRSGGMSNELNNIISRTTDGVYEGVAIGGDRYPGSTFMDHVLRYQDTPGVKMIVVLGEIGGTEEYKICRGIKEGRLTKPIVCWCIGTCATMFSSEVQFGHAGACANQASETAVAKNQALKEAGVFVPRSFDELGEIIQSVYEDLVANGVIVPAQEVPPPTVPMDYSWARELGLIRKPASFMTSICDERGQELIYAGMPITEVFKEEMGIGGVLGLLWFQKRLPKYSCQFIEMCLMVTADHGPAVSGAHNTIICARAGKDLVSSLTSGLLTIGDRFGGALDAAAKMFSKAFDSGIIPMEFVNKMKKEGKLIMGIGHRVKSINNPDMRVQILKDYVRQHFPATPLLDYALEVEKITTSKKPNLILNVDGLIGVAFVDMLRNCGSFTREEADEYIDIGALNGIFVLGRSMGFIGHYLDQKRLKQGLYRHPWDDISYVLPEHMSM 04EB8D05059409E5 q75vw6_hydth ccsB protein protein Hydrogenobacter thermophilus Hydrogenobacter thermophilus MERRWKIGTPYLNDSTRIIVMGITGREASQVVAESEALYPGFVVAGVTPGKGGSEVAGVPVYNTVREAQERHPEINTGIVYVPPASVKDAVIELIDAGIGVIFIITEHVPIRDTVYFYHYAKERGTIIVGPTSLGCIIPKIPARIGAIGGKDPSVAYADGGLVILSKSGGLTTTTAEMFKRRGWGVYMALALGGDVISCTTFADAIENLADDPNVKGVIIQGEVGGSYEEQAAETILRLWKEGRWNKPVAAFVAGRFQESLEGVSFGHAGAIVERGKGKATDKIRAFNEVGKITGLVKVAEFYHDLVHCIEELGVPRDFEDSTPEGKVKPLYSTINEENCQFKA 4078F60D9EC245D3 q9ajc4_chlli aclA protein protein Chlorobium limicola Chlorobium limicola MSILANKDTRAVIIGGVAGVNAAKRMAQFDFLVNRPLTVQAFVYPPEAGQQKEIFRGGELKNVTVYDSLAPALEEHPDINTALIYLGASRAAQAAKEALESPNIQLVSMITEGVPEKDAKRLKKLAQKLGKMLNGPSSIGIMSAGECRLGVIGGEFKNLKLCNLYRQGSFGVLTKSGGLSNEAMWLCAQNGDGITSAVAIGGDAYPGTDFVTYLEMFEKDPATKAVVMIGEVGGNLEEEAAEWLAAEPRRIKLIAAIGGTCQEVLPQGMKFGHAGAKEGKKGAGSARSKMNALRDAGAYVPDTFGGLSKEIKKVYEELIAAGEISTEIDEAVLPELPPRVQEVMKQGEVIVEPLIRTTISDDRGEEPRYAGYAASELCSKGYGIEDVIGLLWNKKLPTREESEIIKRIVMISADHGPAVSGAFGSILAACAGIDMPQAVSAGMTMIGPRFGGAVTNAGKYFKMAVEDYPNDIPGFLSWMKKNVGPVPGIGHRVKSVKNPDQRVKYLVSYIKNETSLHTPCLDYALEVEKVTTAKKGNLILNVDGTIGCILMDLDFPVHSLNGFFVLARTIGMIGHWIDQNNQNSRLIRLYDYLINYAVKPEQEVPEKK 35401DFE784E3733 q9aqh6_chlli ATP citrate synthase aclB protein protein Chlorobium limicola Chlorobium limicola MAKILEGPAMKLFNKWGIPVPNYVVIMDPDRLAQLGEANKWLRESKLVVKAHEAIGGRFKLGLVKIGLNLEQAIEAAKEMLGAKVGTAEIGQVIIAEMLEHDAEFYVSIIGNKDGAELLISKHGGVDIEDNWDSVRRIQIELDENPTIEQLTELAKDAGFEGEIAERVGKICSRLILCFDNEDAQSIEINPLVIRKSDMRFAALDAVMNVDYDARFRHADWDFKPVSEIGRPFTEAEQQIMEIDSRIKGSVKFVEVPGGEIALLTAGGGASVFYADAVVARGGTIANYAEYSGDPADWAVEALTETICRLPNIKHIIVGGAIANFTDVKATFSGIINGFRESKSKGYLEGVKIWVRRGGPNEAQGLAAIKQLQEEGFDIHVYDRSMPMTDIVDLAMKS 3B80CB773F1AF378 a0a1v4vdz9_9eury sucD A4E43_00138 protein protein Methanosaeta sp. PtaB.Bin005 Methanosaeta sp. PtaB.Bin005 MSRKDYVLFDINTKAFVYGYQTNAIQRMLDFDYVCKRSSPSISAIINPSRAGIHKAFWGTKEIILPMYKTIPLAALAYPEADVMVNFASHRSAFETTMEALKEDTIRIVAVIAEGVPERQSRVMAATARKLDKIVIGPATVGGMTAGAFRIGNTAGTIENIIASKLYRPGCVGFVSKSGGMLNEAFNIISRNSDGIYEGVAIGGDRYPGSNMLDHILRYERNPAIKMIACLGELGGEDEYMIIQALKEKKITKPLVAWVTGTCSPYLPASVQFGHAGAKANTEKETAQAKNDAFRQAGAYVPRSFDDYGEMVRQVYDMLLTRGIVQKFDEPEVPRIPTDYSKALATGDIRKPTTFICTISDDSGEELLYAGKKLSDVLDRKMGIGGVIGLLWFKKELPEYAAHFIELVIQIVADHGPAVSGAHNAIVASCAGKDLISSLCSGLLTIGPRFGGAIDDAAREFKRAQETGLAPEQFVGEMKKKGINIPGIGHKIKSVKNPDKRVQLLISYARANFPSTELLNYALQVEELTTAKKGNLILNVDGCIGILFIDLMSSCGAFSKEEIDEVVRLGYLNGLFALGRSIGLIGHILDQKRLGSRLYRHPAEDIAYMMPSEEEIQCKRDR 9E8A46B9DED3958E q75vw8_hydth ATP citrate synthase ccsA protein protein Hydrogenobacter thermophilus Hydrogenobacter thermophilus MNLYEYEAYDKIFKKYGIPTPEYMFESSVSDRLVEFVNQLGECVVKSQVLVGKRGKAGAVKVCSDPQSAIETAQALLNYPVYGEMPVGVLVARKVNILKELYASITYSTEVRAPVLTLSLEGGMDIEEVPPEKVRSWTINPLKGLYPHMVRNYLLELGFPQEYMGILRELSEVVSNMYRAFWEAEARLLEINPLAICDVNGKLKVYALDAVVTIDDDASVPPSKIYGVRTAMKRPPTEREIEASLIDRDDHRGKAGSYVEVDGDIAMMTFGGGGSTVTIETTYAIGLKPANFTDIGGNPPAEKMYKITKIILSKPGIRGVLVCGGTANNTRIDVTLGEGVANAIRDLYKEGKLNPDWIWVVRRNGPEAEKGLRMLYEAFKECKVKGEIYDSSLPLTEAPIRLKELLDICTSAQSEDRHLTEEQAKDMGI ADA5E8C52664DA56 ccsa-ccsb-1 1 9 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) 5 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction Extended Data Fig 1, Extended Data Table 1 acla-aclb-1 1 6 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) 7 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction Extended Data Fig 1, Extended Data Table 1 a0a0w8fb26_9zzzz-sucd-1 1 8 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) 3 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction Extended Data Fig 1, Extended Data Table 1 acly-2 1 4 structure determination identification by structure determination identification by structure determination structure determination predetermined predetermined participant predetermined unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction Extended Data Fig 1, Extended Data Table 1 acla-1 1 6 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction Extended Data Fig 1, Extended Data Table 1 ccl-1 1 2 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) direct interaction direct interaction Extended Data Fig 1, Extended Data Table 1