IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ miR-1266 Contributes to Pancreatic Cancer Progression and Chemoresistance by the STAT3 and NF-κB Signaling Pathways. miR-1266 Contributes to Pancreatic Cancer Progression and Chemoresistance by the STAT3 and NF-κB Signaling Pathways. Molecular therapy. Nucleic acids 2018 imex curation Zhang X., Ren D., Wu X., Lin X., Ye L., Lin C., Wu S., Zhu J., Peng X., Song L. songlb@sysucc.org.cn 13-Nov-2020: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-aspc-1 Human caucasian pancreas adenocarcinoma cell line aspc-1 Human caucasian pancreas adenocarcinoma cell line pancreas mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag luciferase tag visualisation by luciferase assay tag luciferase Zhang X., Ren D., Wu X., Lin X., Ye L., Lin C., Wu S., Zhu J., Peng X., Song L. songlb@sysucc.org.cn Accepted 2020-SEP-28 AT 09:52 BST AT 09:52 BST by KALPANAP Molecular therapy. Nucleic acids 2018 Only protein-protein interactions imex curation imex curation miR-1266 Contributes to Pancreatic Cancer Progression and Chemoresistance by the STAT3 and NF-κB Signaling Pathways. miR-1266 Contributes to Pancreatic Cancer Progression and Chemoresistance by the STAT3 and NF-κB Signaling Pathways. Molecular therapy. Nucleic acids 2018 imex curation Zhang X., Ren D., Wu X., Lin X., Ye L., Lin C., Wu S., Zhu J., Peng X., Song L. songlb@sysucc.org.cn 13-Nov-2020: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-panc1 Homo sapiens pancreatic carcinoma cell line PANC-1 panc1 Human pancreatic carcinoma cell line PANC-1 Established from a pancreatic carcinoma of ductal origin from a 56-year-old Caucasian male. Cells possess the type B phenotype for G6PD. mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag luciferase tag visualisation by luciferase assay tag luciferase Zhang X., Ren D., Wu X., Lin X., Ye L., Lin C., Wu S., Zhu J., Peng X., Song L. songlb@sysucc.org.cn Accepted 2020-SEP-28 AT 09:52 BST AT 09:52 BST by KALPANAP Molecular therapy. Nucleic acids 2018 Only protein-protein interactions imex curation imex curation hsa-mir-1266-5p mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA human Homo sapiens Human CCUCAGGGCUGUAGAACAGGGCU mrna_tnip1 TNFAIP3 interacting protein 1 mRNA mrna messenger rna mRNA mrna human Homo sapiens Human AGTGAGCCGAGGAGCCTTCATAGGGACAGCCGCCCCTGGTGCACACACCCTCGTATTCTCCTGCCCTTCCCCAGCCAGGCGGGCACCACGGCAGGGGCTGAGCTACCCTCATGGAAGGGAGAGGACCGTACCGGATCTACGACCCTGGGGGCAGCGTGCCCTCAGGAGAGGCATCCGCAGCTTTTGAGCGCCTAGTGAAGGAGAATTCCCGGCTGAAGGAAAAAATGCAAGGGATAAAGATGTTAGGGGAGCTTTTGGAAGAGTCCCAGATGGAAGCGACCAGGCTCCGGCAGAAGGCAGAGGAGCTAGTGAAGGACAACGAGCTGCTCCCACCACCTTCTCCCTCCTTGGGCTCCTTCGACCCCCTGGCTGAGCTCACAGGAAAGGACTCAAATGTCACAGCATCTCCCACAGCCCCTGCATGCCCCAGTGACAAGCCAGCACCAGTCCAGAAGCCTCCATCCAGTGGCACCTCCTCTGAATTTGAAGTGGTCACTCCTGAGGAGCAGAATTCACCAGAGAGCAGCAGCCATGCCAATGCGATGGCGCTGGGCCCCCTGCCCCGTGAGGACGGCAACCTGATGCTGCACCTGCAGCGCCTGGAGACCACGCTGAGTGTGTGTGCCGAGGAGCCGGACCACGGCCAGCTCTTCACCCACCTGGGCCGCATGGCCCTGGAGTTCAACCGACTGGCATCCAAGGTGCACAAGAATGAGCAGCGCACCTCCATTCTGCAGACCCTGTGTGAGCAGCTTCGGAAGGAGAACGAGGCTCTGAAGGCCAAGTTGGATAAGGGCCTGGAACAGCGGGATCAGGCTGCCGAGAGGCTGCGGGAGGAAAATTTGGAGCTCAAGAAGTTGTTGATGAGCAATGGCAACAAAGAGGGTGCGTCTGGGCGGCCAGGCTCACCGAAGATGGAAGGGACAGGCAAGAAGGCAGTGGCTGGACAGCAGCAGGCTAGTGTGACGGCAGGTAAGGTCCCAGAGGTGGTGGCCTTGGGCGCAGCCGAGAAGAAGGTGAAGATGCTGGAGCAGCAGCGCAGTGAGCTGCTGGAAGTGAACAAGCAGTGGGACCAGCATTTCCGGTCCATGAAGCAGCAGTATGAGCAGAAGATCACTGAGCTGCGTCAGAAGCTGGCTGATTTGCAGAAGCAGGTGACTGACCTGGAGGCCGAGCGGGAGCAGAAGCAGCGTGACTTTGACCGCAAGCTCCTCCTGGCCAAGTCCAAGATTGAAATGGAGGAGACCGACAAGGAGCAGCTGACAGCAGAGGCCAAGGAGCTGCGCCAAAAGGTCAAGTACCTGCAGGATCAGCTGAGCCCACTCACCCGACAGCGTGAGTACCAGGAAAAGGAGATCCAGCGGCTCAACAAGGCCCTGGAGGAAGCACTGAGCATCCAAACCCCGCCATCATCTCCACCAACAGCATTTGGGAGCCCAGAAGGAGCAGGGGCCCTCCTAAGGAAACAGGAGCTGGTCACGCAGAATGAGTTGCTGAAACAGCAGGTGAAGATCTTCGAGGAGGACTTCCAGAGGGAGCGCAGTGATCGTGAGCGCATGAATGAGGAGAAGGAAGAGCTGAAGAAGCAAGTGGAGAAGCTGCAGGCCCAGGTCACCCTGTCAAATGCCCAGCTAAAAGCATTCAAAGATGAGGAGAAGGCAAGAGAAGCCCTCAGACAGCAGAAGAGGAAAGCAAAGGCCTCAGGAGAGCGTTACCATGTGGAGCCCCACCCAGAACATCTCTGCGGGGCCTACCCCTACGCCTACCCGCCCATGCCAGCCATGGTGCCACACCATGGCTTCGAGGACTGGTCCCAGATCCGCTACCCCCCTCCCCCCATGGCCATGGAGCACCCGCCCCCACTCCCCAACTCGCGCCTCTTCCATCTGCCGGAATACACCTGGCGTCTACCCTGTGGAGGGGTTCGAAATCCAAATCAGAGCTCCCAAGTGATGGACCCTCCCACAGCCAGGCCTACAGAACCAGAGTCTCCAAAAAATGACCGTGAGGGGCCTCAGTGAGACCAGATTGTGTCATTTGGCTCCACCTTCATCTTGCAGAGCCAGCTGATCTCAGATTGCCAAGAAACTAGAAGCCACTTGCACGGTGTGGCCAGAGCCTCAGCTGGATGAGAGGCTGAGATGGGTGGCCAGCTTGTACACCAGTCCCTGAACTGAGCTGTTTACAGGACTGGGGAGGCTCCACCCAGAAGGCTTTCATTTGTACTCTGCTGGGAGTGACTGGGAAAAACTCCTTCCCTGCTGCTGAGTGGAGAGAGGCCTCATCCGGCTTTGACCCACCATCCGTTGCAGAAGCCTCCAGGAGCAGCAATCCTAAGAGTGGGAGGCAGCCAAGACCCCCTTCCTTCAAAACCTCCCGGAAGTGGTTTCAGGCCCTCTAGTTGCCATGACCAATTTGTGTGTGTGTTTAATTTTTGCTTCAAGCTCTGTAGCAGGACCTGCCCCACGCACACCCCTACCCCTCTGTGAGGAGCTGTGGGAAGTGTGGGTTTGTCTCCAGAACAGAAGAGAATGATGGATATTCTGGCTCTGGGGCCCTCTCCACCACCACTCACAGTAGCCTTGCTGAAGCCATCACAGATGGGAGAAGGCCATGCCAGCCACGTCCGCCGAGGGGCGCCAGCCTGAAGCTGCCAGGCCCTGAGGTTCAGACCCTGGACCCCATAGCTGGAGGCCTGTGGTGCCAGAAGCCCAGATTAGGGTGGCTGTCCATCCCTGGATAGCTATTTGCACGAATCATGGACATAAATCCAAGTTGAAGAAGA mrna socs3 suppressor of cytokine signaling 3 mRNA mrna messenger rna mRNA mrna human Homo sapiens Human GGCTCCGACTTGGACTCCCTGCTCCGCTGCTGCCGCTTCGGCCCCGCACGCAGCCAGCCGCCAGCCGCCCGCCCGGCCCAGCTCCCGCCGCGGCCCCTTGCCGCGGTCCCTCTCCTGGTCCCCTCCCGGTTGGTCCGGGGGTGCGCAGGGGGCAGGGCGGGCGCCCAGGGGAAGCTCGAGGGACGCGCGCGCGAAGGCTCCTTTGTGGACTTCACGGCCGCCAACATCTGGGCGCAGCGCGGGCCACCGCTGGCCGTCTCGCCGCCGCGTCGCCTTGGGGACCCGAGGGGGCTCAGCCCCAAGGACGGAGACTTCGATTCGGGACCAGCCCCCCGGGATGCGGTAGCGGCCGCTGTGCGGAGGCCGCGAAGCAGCTGCAGCCGCCGCCGCGCAGATCCACGCTGGCTCCGTGCGCCATGGTCACCCACAGCAAGTTTCCCGCCGCCGGGATGAGCCGCCCCCTGGACACCAGCCTGCGCCTCAAGACCTTCAGCTCCAAGAGCGAGTACCAGCTGGTGGTGAACGCAGTGCGCAAGCTGCAGGAGAGCGGCTTCTACTGGAGCGCAGTGACCGGCGGCGAGGCGAACCTGCTGCTCAGTGCCGAGCCCGCCGGCACCTTTCTGATCCGCGACAGCTCGGACCAGCGCCACTTCTTCACGCTCAGCGTCAAGACCCAGTCTGGGACCAAGAACCTGCGCATCCAGTGTGAGGGGGGCAGCTTCTCTCTGCAGAGCGATCCCCGGAGCACGCAGCCCGTGCCCCGCTTCGACTGCGTGCTCAAGCTGGTGCACCACTACATGCCGCCCCCTGGAGCCCCCTCCTTCCCCTCGCCACCTACTGAACCCTCCTCCGAGGTGCCCGAGCAGCCGTCTGCCCAGCCACTCCCTGGGAGTCCCCCCAGAAGAGCCTATTACATCTACTCCGGGGGCGAGAAGATCCCCCTGGTGTTGAGCCGGCCCCTCTCCTCCAACGTGGCCACTCTTCAGCATCTCTGTCGGAAGACCGTCAACGGCCACCTGGACTCCTATGAGAAAGTCACCCAGCTGCCGGGGCCCATTCGGGAGTTCCTGGACCAGTACGATGCCCCGCTTTAAGGGGTAAAGGGCGCAAAGGGCATGGGTCGGGAGAGGGGACGCAGGCCCCTCTCCTCCGTGGCACATGGCACAAGCACAAGAAGCCAACCAGGAGAGAGTCCTGTAGCTCTGGGGGGAAAGAGGGCGGACAGGCCCCTCCCTCTGCCCTCTCCCTGCAGAATGTGGCAGGCGGACCTGGAATGTGTTGGAGGGAAGGGGGAGTACCACCTGAGTCTCCAGCTTCTCCGGAGGAGCCAGCTGTCCTGGTGGGACGATAGCAACCACAAGTGGATTCTCCTTCAATTCCTCAGCTTCCCCTCTGCCTCCAAACAGGGGACACTTCGGGAATGCTGAACTAATGAGAACTGCCAGGGAATCTTCAAACTTTCCAACGGAACTTGTTTGCTCTTTGATTTGGTTTAAACCTGAGCTGGTTGTGGAGCCTGGGAAAGGTGGAAGAGAGAGAGGTCCTGAGGGCCCCAGGGCTGCGGGCTGGCGAAGGAAATGGTCACACCCCCCGCCCACCCCAGGCGAGGATCCTGGTGACATGCTCCTCTCCCTGGCTCCGGGGAGAAGGGCTTGGGGTGACCTGAAGGGAACCATCCTGGTACCCCACATCCTCTCCTCCGGGACAGTCACCGAAAACACAGGTTCCAAAGTCTACCTGGTGCCTGAGAGCCCAGGGCCCTTCCTCCGTTTTAAGGGGGAAGCAACATTTGGAGGGGATGGATGGGCTGGTCAGCTGGTCTCCTTTTCCTACTCATACTATACCTTCCTGTACCTGGGTGGATGGAGCGGGAGGATGGAGGAGACGGGACATCTTTCACCTCAGGCTCCTGGTAGAGAAGACAGGGGATTCTACTCTGTGCCTCCTGACTATGTCTGGCTAAGAGATTCGCCTTAAATGCTCCCTGTCCCATGGAGAGGGACCCAGCATAGGAAAGCCACATACTCAGCCTGGATGGGTGGAGAGGCTGAGGGACTCACTGGAGGGCACCAAGCCAGCCCACAGCCAGGGAAGTGGGGAGGGGGGGCGGAAACCCATGCCTCCCAGCTGAGCACTGGGAATGTCAGCCCAGTAAGTATTGGCCAGTCAGGCGCCTCGTGGTCAGAGCAGAGCCACCAGGTCCCACTGCCCCGAGCCCTGCACAGCCCTCCCTCCTGCCTGGGTGGGGGAGGCTGGAGGTCATTGGAGAGGCTGGACTGCTGCCACCCCGGGTGCTCCCGCTCTGCCATAGCACTGATCAGTGACAATTTACAGGAATGTAGCAGCGATGGAATTACCTGGAACAGTTTTTTGTTTTTGTTTTTGTTTTTGTTTTTGTGGGGGGGGGCAACTAAACAAACACAAAGTATTCTGTGTCAGGTATTGGGCTGGACAGGGCAGTTGTGTGTTGGGGTGGTTTTTTTCTCTATTTTTTTGTTTGTTTCTTGTTTTTTAATAATGTTTACAATCTGCCTCAATCACTCTGTCTTTTATAAAGATTCCACCTCCAGTCCTCTCTCCTCCCCCCTACTCAGGCCCTTGAGGCTATTAGGAGATGCTTGAAGAACTCAACAAAATCCCAATCCAAGTCAAACTTTGCACATATTTATATTTATATTCAGAAAAGAAACATTTCAGTAATTTATAATAAAGAGCACTATTTTTTAATGAAAAA mrna_ptpn11 protein tyrosine phosphatase non-receptor type 11 mrna messenger rna mRNA mrna human Homo sapiens Human AGTCTCCGGGATCCCCAGGCCTGGAGGGGGGTCTGTGCGCGGCCGGCTGGCTCTGCCCCGCGTCCGGTCCCGAGCGGGCCTCCCTCGGGCCAGCCCGATGTGACCGAGCCCAGCGGAGCCTGAGCAAGGAGCGGGTCCGTCGCGGAGCCGGAGGGCGGGAGGAACATGACATCGCGGAGATGGTTTCACCCAAATATCACTGGTGTGGAGGCAGAAAACCTACTGTTGACAAGAGGAGTTGATGGCAGTTTTTTGGCAAGGCCTAGTAAAAGTAACCCTGGAGACTTCACACTTTCCGTTAGAAGAAATGGAGCTGTCACCCACATCAAGATTCAGAACACTGGTGATTACTATGACCTGTATGGAGGGGAGAAATTTGCCACTTTGGCTGAGTTGGTCCAGTATTACATGGAACATCACGGGCAATTAAAAGAGAAGAATGGAGATGTCATTGAGCTTAAATATCCTCTGAACTGTGCAGATCCTACCTCTGAAAGGTGGTTTCATGGACATCTCTCTGGGAAAGAAGCAGAGAAATTATTAACTGAAAAAGGAAAACATGGTAGTTTTCTTGTACGAGAGAGCCAGAGCCACCCTGGAGATTTTGTTCTTTCTGTGCGCACTGGTGATGACAAAGGGGAGAGCAATGACGGCAAGTCTAAAGTGACCCATGTTATGATTCGCTGTCAGGAACTGAAATACGACGTTGGTGGAGGAGAACGGTTTGATTCTTTGACAGATCTTGTGGAACATTATAAGAAGAATCCTATGGTGGAAACATTGGGTACAGTACTACAACTCAAGCAGCCCCTTAACACGACTCGTATAAATGCTGCTGAAATAGAAAGCAGAGTTCGAGAACTAAGCAAATTAGCTGAGACCACAGATAAAGTCAAACAAGGCTTTTGGGAAGAATTTGAGACACTACAACAACAGGAGTGCAAACTTCTCTACAGCCGAAAAGAGGGTCAAAGGCAAGAAAACAAAAACAAAAATAGATATAAAAACATCCTGCCCTTTGATCATACCAGGGTTGTCCTACACGATGGTGATCCCAATGAGCCTGTTTCAGATTACATCAATGCAAATATCATCATGCCTGAATTTGAAACCAAGTGCAACAATTCAAAGCCCAAAAAGAGTTACATTGCCACACAAGGCTGCCTGCAAAACACGGTGAATGACTTTTGGCGGATGGTGTTCCAAGAAAACTCCCGAGTGATTGTCATGACAACGAAAGAAGTGGAGAGAGGAAAGAGTAAATGTGTCAAATACTGGCCTGATGAGTATGCTCTAAAAGAATATGGCGTCATGCGTGTTAGGAACGTCAAAGAAAGCGCCGCTCATGACTATACGCTAAGAGAACTTAAACTTTCAAAGGTTGGACAAGGGAATACGGAGAGAACGGTCTGGCAATACCACTTTCGGACCTGGCCGGACCACGGCGTGCCCAGCGACCCTGGGGGCGTGCTGGACTTCCTGGAGGAGGTGCACCATAAGCAGGAGAGCATCATGGATGCAGGGCCGGTCGTGGTGCACTGCAGTGCTGGAATTGGCCGGACAGGGACGTTCATTGTGATTGATATTCTTATTGACATCATCAGAGAGAAAGGTGTTGACTGCGATATTGACGTTCCCAAAACCATCCAGATGGTGCGGTCTCAGAGGTCAGGGATGGTCCAGACAGAAGCACAGTACCGATTTATCTATATGGCGGTCCAGCATTATATTGAAACACTACAGCGCAGGATTGAAGAAGAGCAGAAAAGCAAGAGGAAAGGGCACGAATATACAAATATTAAGTATTCTCTAGCGGACCAGACGAGTGGAGATCAGAGCCCTCTCCCGCCTTGTACTCCAACGCCACCCTGTGCAGAAATGAGAGAAGACAGTGCTAGAGTCTATGAAAACGTGGGCCTGATGCAACAGCAGAAAAGTTTCAGATGAGAAAACCTGCCAAAACTTCAGCACAGAAATAGATGTGGACTTTCACCCTCTCCCTAAAAAGATCAAGAACAGACGCAAGAAAGTTTATGTGAAGACAGAATTTGGATTTGGAAGGCTTGCAATGTGGTTGACTACCTTTTGATAAGCAAAATTTGAAACCATTTAAAGACCACTGTATTTTAACTCAACAATACCTGCTTCCCAATTACTCATTTCCTCAGATAAGAAGAAATCATCTCTACAATGTAGACAACATTATATTTTATAGAATTTGTTTGAAATTGAGGAAGCAGTTAAATTGTGCGCTGTATTTTGCAGATTATGGGGATTCAAATTCTAGTAATAGGCTTTTTTATTTTTATTTTTATACCCTTAACCAGTTTAATTTTTTTTTTCCTCATTGTTGGGGATGATGAGAAGAAATGATTTGGGAAAATTAAGTAACAACGACCTAGAAAAGTGAGAACAATCTCATTTACCATCATGTATCCAGTAGTGGATAATTCATTTTGATGGCTTCTATTTTTGGCCAAATGAGAATTAAGCCAGTGCCTGAGACTGTCAGAAGTTGACCTTTGCACTGGCATTAAAGAGTCATAGAAAAAGAATCATGGATATTTATGAATTAAGGTAAGAGGTGTGGCTTTTTTTTTTTTCTTTTTTCCAGCCGTTGACCAATTATAGTTCGGCTGTTGACTGAGAAGTTTGTGGTGGGAAAACGTTTGCCATATTTTCTTTGCATTTGAATAATTGTCTTGTACTTAGAAAAAAGGCGTCTATGAATGACCAGTGTTTTTGGTCGCCAAATGTTGCTGACAAACTTATCCCAAAACTTTAGTGGCTTAAAAAAACCTGCCCCCAACTGTTAGTCAATCTGAGCTGGGCTCAGCTGGGCTGTTCTTCTGCCAGCCTGCAGGTGGCCACTCATGTGGTCAGCAGGTCGGCGGAGAGACTGGGATGGCTGGGCTTCTCTCTCTGCCTGCAGTCCTGAGTCTCTCCTTCTTCGTGTAGTCTCTTTCAGTGGCCTGGCTGGCAGGGTAGCTAGACCTCTCACATGCAGCTCAGAGCTCCCAAGAGCTCAAAAGCAGAAATGGCCAGGCCTTCTGAAAACTTAAGTCCAGAATTGTCACAGTGTCCCTTCTACTTCCCTCTATTGATGATGATGATGATGATGATGATGATGATGATGATGATGATGATGGTTTTTTCTAATCAGAAGAAAGCTGGGGTATGCCCTCTACTTACTAAACAAGTCACAAGCCCAGCTCAGATTCAAGAAAAGGGTGTGAAGTAGAGGTGCAGTTAAGTGGGGGGCCACTAGTCTAACAGACGGTCACAACCAGTGCCATGGAAAACCAAGGATATTAGCAAAAGCAGAAGTTGCTAGTGACCTTGGGAAGCCGAAGCTGCTTACAGTAGCTGGGACAAGCTGAAAGTCAGACTAAGAAATAAAGAGAGGGCCTTCAAGAAGCTTCCTGAATGATTTCTGCTAGCCCTGAGCCTATTTTTGGAACCAGCACTTGGGGAAACTGATCTTGTGAGGATGGATGTGTTTAGGGACACAGGGCTTTTGAGAGCAGCACCACCCCACTGGGGCATCCCCAGACTTGGGAAACGTGACTCTTTCTTAATGCCACTGGGTTTTAGTCAGGCCACAGTGAGAAGGAACAGCCCTAACAGGCCTCCAGCCAGGTTGAATGAGCTCATTTTTGTTGTAGCCAACCAGTAAGATTTGCTAATGTTCTACATTAAGTGCCTTCTCCAAAGACATCCCTCTTTGCCTCATATGTTGAATCATCCAGTGCGGATATTTCAATGAAAATATCATTGGTTGACTTTTGTGATGGTAATAATGCTATGGCATCTTTGCCATGAAGTTGTGGCCTCCTTGGATTCTTCTGACTTTGGCTTCTGAAAGGAAGGCCTAGATCCAGCCCTGGTGGTAGTTCCTTTCTGAGGTCTCTCAGTCCCTTGAGACTTTGGGGTAGTTTGGCTGCCATTCTCACTGACAAAATGTATATCAGCCCCCACCTCCACCCCCCAATATTCCTTGAACTTTGAATTGCTTCAGAACACAGGTGTGGCCTGAAGGTATTCCCTTATTAGGGAAGTGTCACTGCTGTCTTCTAGTCAAACTTGTAAAGAAAAAGATTCCAGTTCAGTATTTGCAGCAAGAAGCTTGAATGCTGTTCTTTTTATCGCATTGTTACATCGACTCATTCTCCATTTTGCTTTGGTTTTGTCTTGACTTGACTTGACTTTGGGGGTAAAGTCTTTCACCAGCACACAAGAGTTTGATTGTACAAATATATCTTCTGCATTAACATCTCTGCCTGTTGCTTAAGATCAGTTGCTTTTATACTCAGAATGGAAATACCTGATCTTGGCTAGTTTTGTTATAAGATATTGATTTCATTTAGATTTCCCTCCACGAGGTCAGCAAACTATCATGTTCTTATGTAAACTTAGGCCAAGGCCAGAGTTATCATAGTCCCTAGGTTGCTACGGCTTATCATGTGCTTGGTAAAAGGTGATCGCAGGTTCTCAGACGAGTTTACTTTACATGAGATGGAATCAGGCAGAGAGGCTGGGATGATGGAGAAAGCTCGAGGTGAAGTTTTAAAAAAAAAGTTGTGGAAAGGAAAGTTCCAAAGAGGTGGTTTCTGAGGAAGTCAGAGCGCCCAGGGCCAGAGCAGTCAGTAATGGGTGAATGAGGTTGTTTGGAAAGTCGGTGTGACAGACACATGGATGCCATCTACTTCTAGGTTGCTGGTGGGTATTAAATATGCACAATATTCCATAGCTCACTGAGGATTTTAAAATTATAAGCATAGGATTTTATATTTTGGGGTGAAAGAATTATCTGGCACATTAGGTATTGGAGTTTAAAAAAAAAGCCAAATTTCACAGTCTTAATAACTTTTTTTAAAAAAAACTAAAAGGCGCTTCATGTCCAGTGTGTGGCCCTTCTGAAACTTATGGTCATCTCTCCCACTGAAACCAAGGTCTTTTCAAATGTGGCTAAATGGGGATGAGGAGACACGGGTAGGACTTTCTTGGTGTGTGTGCATTCTTTAAAGAGCCAAGTTGCTTCGGGGAAACAGCCAGGAAAATGGTCAAGATTATTTTTAGAGGTTATTTTATTGGGGATTTTAAGAACTAATAACATCTTGAGTTATTTTTAATTCAGGGGGATGTGGAAAGGTTTGCAATTGTCAAGTGTTTTGTTGTAGCTTAGTATCCATAAGGGAAACTTAGACTATAGACATAACTACAAAGCCAGTGCAGCTTTTGTTTTCTGTATGTTGTTGGGGGATCAACTTTCACACATAGCAAGCACATGGCCTCCCTGATGTCAGGATGCCTTTGTTAGGATCTGTATTTGCCCTTAATTTTGTTGAAATCTTTTTTCCTTCTTCCTCTTGAAAAGTTCCAAAATATAGTTTATTGTATCTTTCATCACTAAAAATTTGTTCCTTTTTCACTATGGGCAGTTCACACAAGGCAAAAACTATTGAACAGTTGGTTTTAGTGTGTTGTATAACTTTGCTGTATATCAAACTAATTTTGACAAGTTTTCATCCTAAGCCTCAAATCATGTAATTAATAATTTGCCTGTTTATTTATGACCTAATTGTGATTCTTTTATTAATAAAAGCTAATGGGAAAAGGATCCCTGATTAAGCTGATGACTAGACCTACAATTAATTTTCCTGCAGTATATGAAGTATTGTACCAGAGTATTAAAAGATATGTAATATTTTATTGATAAATCTATCCTTTAAAAGGAATACGTTTTAGGATGTCATCATTTTGATGTGAATCATGTAAATGTTGATAATATGCTGTTTATTATACATTTAGTGTTTCAAGAGATTCACTTAATTGCCTTTTTGCCCACGTATATTATGTAGTCTATTTGCAACTGTTCTTAAAAAAATGACATTAAAAGAATAGTTTATGTAGAGAAACATTAGTGGATGTTAATTGTCTCCCCACCTATATTTATGGGTGTTAGCGCAACTGCTTTGCTAGTTGCAAAGCTGTATTATCAGAGTAAAAGTGTATTTGTAAACTGTATGGGAACTAAAAATTAGGAATAAAACCATTTTCTTATATGATGGCA mrna_itch itchy E3 ubiquitin protein ligase (ITCH), mRNA mrna messenger rna mRNA mrna human Homo sapiens Human AGTAGCTGTGGTCGGGGCTCGGGACCGGCTGCCATCTTAGTCTAGGGACTGAGGAGTCGCCGCCGCCCCGAGTCCCGGTACCATGCATTTCACGGTGGCCTTGTGGAGACAACGCCTTAACCCAAGGAAGTGACTCAAACTGTGAGAACTTCAGGTTTTCCAACCTATTGGTGGTATGTCTGACAGTGGATCACAACTTGGTTCAATGGGTAGCCTCACCATGAAATCACAGCTTCAGATCACTGTCATCTCAGCAAAACTTAAGGAAAATAAGAAGAATTGGTTTGGACCAAGTCCTTACGTAGAGGTCACAGTAGATGGACAGTCAAAGAAGACAGAAAAATGCAACAACACAAACAGTCCCAAGTGGAAGCAACCCCTTACAGTTATCGTTACCCCTGTGAGTAAATTACATTTTCGTGTGTGGAGTCACCAGACACTGAAATCTGATGTTTTGTTGGGAACTGCTGCATTAGATATTTATGAAACATTAAAGTCAAACAATATGAAACTTGAAGAAGTAGTTGTGACTTTGCAGCTTGGAGGTGACAAAGAGCCAACAGAGACAATAGGAGACTTGTCAATTTGTCTTGATGGGCTACAGTTAGAGTCTGAAGTTGTTACCAATGGTGAAACTACATGTTCAGAAAGTGCTTCTCAGAATGATGATGGCTCCAGATCCAAGGATGAAACAAGAGTGAGCACAAATGGATCAGATGACCCTGAAGATGCAGGAGCTGGTGAAAATAGGAGAGTCAGTGGGAATAATTCTCCATCACTCTCAAATGGTGGTTTTAAACCTTCTAGACCTCCAAGACCTTCACGACCACCACCACCCACCCCACGTAGACCAGCATCTGTCAATGGTTCACCATCTGCCACTTCTGAAAGTGATGGGTCTAGTACAGGCTCTCTGCCGCCGACAAATACAAATACAAATACATCTGAAGGAGCAACATCTGGATTAATAATTCCTCTTACTATATCTGGAGGCTCAGGCCCTAGGCCATTAAATCCTGTAACTCAAGCTCCCTTGCCACCTGGTTGGGAGCAGAGAGTGGACCAGCACGGGCGAGTTTACTATGTAGATCATGTTGAGAAAAGAACAACATGGGATAGACCAGAACCTCTACCTCCTGGCTGGGAACGGCGGGTTGACAACATGGGACGTATTTATTATGTTGACCATTTCACAAGAACAACAACGTGGCAGAGGCCAACACTGGAATCCGTCCGGAACTATGAACAATGGCAGCTACAGCGTAGTCAGCTTCAAGGAGCAATGCAGCAGTTTAACCAGAGATTCATTTATGGGAATCAAGATTTATTTGCTACATCACAAAGTAAAGAATTTGATCCTCTTGGTCCATTGCCACCTGGATGGGAGAAGAGAACAGACAGCAATGGCAGAGTATATTTCGTCAACCACAACACACGAATTACACAATGGGAAGACCCCAGAAGTCAAGGTCAATTAAATGAAAAGCCCTTACCTGAAGGTTGGGAAATGAGATTCACAGTGGATGGAATTCCATATTTTGTGGACCACAATAGAAGAACTACCACCTATATAGATCCCCGCACAGGAAAATCTGCCCTAGACAATGGACCTCAGATAGCCTATGTTCGGGACTTCAAAGCAAAGGTTCAGTATTTCCGGTTCTGGTGTCAGCAACTGGCCATGCCACAGCACATAAAGATTACAGTGACAAGAAAAACATTGTTTGAGGATTCCTTTCAACAGATAATGAGCTTCAGTCCCCAAGATCTGCGAAGACGTTTGTGGGTGATTTTTCCAGGAGAAGAAGGTTTAGATTATGGAGGTGTAGCAAGAGAATGGTTCTTTCTTTTGTCACATGAAGTGTTGAACCCAATGTATTGCCTGTTTGAATATGCAGGGAAGGATAACTACTGCTTGCAGATAAACCCCGCTTCTTACATCAATCCAGATCACCTGAAATATTTTCGTTTTATTGGCAGATTTATTGCCATGGCTCTGTTCCATGGGAAATTCATAGACACGGGTTTTTCTTTACCATTCTATAAGCGTATCTTGAACAAACCAGTTGGACTCAAGGATTTAGAATCTATTGATCCAGAATTTTACAATTCTCTCATCTGGGTTAAGGAAAACAATATTGAGGAATGTGATTTGGAAATGTACTTCTCCGTTGACAAAGAAATTCTAGGTGAAATTAAGAGTCATGATCTGAAACCTAATGGTGGCAATATTCTTGTAACAGAAGAAAATAAAGAGGAATACATCAGAATGGTAGCTGAGTGGAGGTTGTCTCGAGGTGTTGAAGAACAGACACAAGCTTTCTTTGAAGGCTTTAATGAAATTCTTCCCCAGCAATATTTGCAATACTTTGATGCAAAGGAATTAGAGGTCCTTTTATGTGGAATGCAAGAGATTGATTTGAATGACTGGCAAAGACATGCCATCTACCGTCATTATGCAAGGACCAGCAAACAAATCATGTGGTTTTGGCAGTTTGTTAAAGAAATTGATAATGAGAAGAGAATGAGACTTCTGCAGTTTGTTACTGGAACCTGCCGATTGCCAGTAGGAGGATTTGCTGATCTCATGGGGAGCAATGGACCACAGAAATTCTGCATTGAAAAAGTTGGGAAAGAAAATTGGCTACCCAGAAGTCATACCTGTTTTAATCGCCTGGACCTGCCACCATACAAGAGCTATGAGCAACTGAAGGAAAAGCTGTTGTTTGCCATAGAAGAAACAGAAGGATTTGGACAAGAGTAACTTCTGAGAACTTGCACCATGAATGGGCAAGAACTTATTTGCAATGTTTGTCCTTCTCTGCCTGTTGCACATCTTGTAAAATTGGACAATGGCTCTTTAGAGAGTTATCTGAGTGTAAGTAAATTAATGTTCTCATTTAGATTTATCTCCCAGTGATTTCTACTCAGCGTTTCCAGAAATCAGGTCTGCAAATGACTAGTCAGAACCTTGCTTAACATGAGATTTTAACACAACAATGAAATTTGCCTTGTCTTATTCCACTAGTTTATTCCTTTAACAACAATATTTTATGTGTGTCAAAAGTCTCACTTGGGAGTAGTGTTTTTTTCTTTTAGACATTCTGCAGACATGCAGGGAAGTCCTTTGGTAACTGCAATATACAAGATTTTCCTATTAAGCCTCTTGGTAAGAGGCATTTGTTAAAAGTGCAAGCTTACTCCTGCTTCTGGGGATGTGAGCAAAATTCGGGCTTGTGTTCTCCCTCTCATTTTAGTCTGACTTGACTATTGTTTTTCCTTTCTGGCGCATGAATCCATACATCATTCCTGGAAGTGAGGCAAGACTCTTGCATCTCTACAAAGTAGTTTTGTCAATTTGAATTCAGGGAAAAGTTGGTCACAGCCTGCAAATGACTTCATTTGGAAGTCTGATTGTTTCAGTTGCCTGACAAATACTACACTTTACAAACAATGTTAACACTGTGATTCCTTCATTGTTTTAAGAAGTTAACCTAGGGCCGGGCATGGTGGCTCATACCTGTAATCCTAGCACTCTGGGAGGCCGAGGCAGGAGGATCCCTTTAGCCCAGGAGTTAAAGACCAGCCTGGGCAACATAGGGAGACCCTGTCTTTTTTTTGGGCAGCGTGGTGGGGGATAAATAAATAAAAGGAAAAAAAACTTAGCCTAGAATTAGAATTAATTTAATTGAATTCATCTAAAGATGTCTCTGGTGATTTTTATATGTTCCGCTATATAATTGATGCTTTATAGTTTTATCATAATCCAACAACTTCAGTTATATTTAATTATTGTTAAGGAGTTTAAGACTAGAAAGACTAGAGTGCTTTCTAGTCCAAATAGAGGTCAGTGAAACAGCTTTTGACATCAGATTTTCATTTGAGAGGGAGAGCTGTGGTACTGGCTAAAAAGAAAGGAAGATAACATCCAGTAACCACAGGAATATATTCTCTGTGAATTAAAAGTCTTCAAAGTTATCATTTCTCTGACATATGTTGGAGTAGTCATTTCCATTCTTTACATTGTCATGAACTGGATTGATAACCCTCATCTGCAATATTTTCACCCCTAAAATTTTTAACAGGGTTTCCTTTTTTTCTCACGACTATTTAAGTTTAGATTGCTCCATTATTAACTGATTAATGCACTTTGAAGTTCTCTGGAATTAATTATTTTAACTTGGCCTAGCTTCGACTGTCAAGGTGGCTGTTATAAATTTGACTTCATTGGCAGTGGATGAAGCCTAAGCCAGCTGAGTCTCTATCATAGCTGAACCCTGAGGACAGCCTCATAGCTCATGTATCAGGGACTTTTGCCACATTTCAGAGGCATAGCATGAACAAGTAATATTAAGCCAAGAATAAGCAGCAGAACCCTGTTCCATATGGAAAAAAGAAAAACAATTTTTTGTCCCTAATGTTCTTCCTTTTACATCCTGGAACAACAATAAAAACATTTTTTTAAACTTGTCTACTGTAAGATACTGCCATCATAAAGCAGAGACTTACATGAGTGAAAGGGTTGCCTCATCAAGCAGCTCAGTGTAAATGGGGAGGCTAGGCTCTCCCCAGCCCTATGGTTTTTTTATTTCATGTACCCCAGGAAATACTGTGTGGTTTCTAAAAGCCCTGGTTGTTAAAAGTAGGGACTCTGCCTTTTTGTTGGTAGGGAGAAAAAACGCTATTGCTTTGTCTTACAGAGCGAATGTCTGCCAACTACCCGTTCATTATATAAGTCTGAACTTGGTAATATATGGCTAATGAAGATTAAGCCCTCTATAAAGACTTCCTGTTGAGGTGAATTCTCATACTGAAATGTAGTTACCTACAATATTTACTAGAGATTTATGAAATTAAATTAAGAGATAATGTAAGAAAATACATTTTTTTGGTTCTATATAATGCTTCATGATTCATTTAGGGACCTAGAAATATTGTGTGAAAATATATAAATATCACCCAAAAGGCTTTCTGCCCTATATTTTTAAAATACAGAATAGTTATATTTGAAGTAGCCCTGGCCCTAGTTCTATAGGGCTTGGCTATTTAATATTTTTATGGAAGAAGTGTTTAGTTCTGGAAAAGGTAAATGCTTGTATATATTTTTGCAGCCTGGGATCTCCCTACTCCATTTTTTCCTTTAATTTAAGTGGCCACATGTATATGTCTTCCCTGCTGTGTTAGGAAAATGGGGGCTGGATATCCCAAGAATCAGAGGTTATATAAAAATACTGCAAATAGACCGCAGACATAAATATCTACCAAATGCTATCTTAAATTTTGGTCCAAACTGAACATATGGAAATAGATTTATTGTAAGTATTTACTTAGAGCTTTTTCTTAAATCTGAACTAACTTGCTTTTAGAAGTCTTTTTCTTTGTAAGCATTGTAAATGCTAATAAATCCTGTTAATTTTTTTTTTTTTTTTTTTTTTTTTTTACTGCATGTTACATTGAAATAAAAACAAAGTAAAATGAGCAATTGCCTTATTGTTCTGCTCTTTTGCAGGGGGTGGGGGTTGGGGAAGACAGCATTCCACAGCCTGGTCAGGAGGGAAGGACCTCACTTGTTTCATCAAATGGAGTGGTTTAAAACTGATCAAGCAGCTCATAATAATGAATTCCTGCTCTGTCTTTTATTATCTTATGTCAGAGTGCAGCAAAATCTCATTTCATAAGACTTACAATAACTCTATTTAAAATTCAGGTATTGTACTCGGGAGGCTGAGGTGGGAGGATCCCAGGAGTTCAAATCCTGCCTGGGCAACATAGCAAGACCCTGTCTCTTAAAAAAACAAAAAGACATATTCAGGTACTGATTTTTCATCAAGAGATTGACATACCAATGATCAGAAATTTTAGTGAAACTTGACTCAACTATACACAAAGTTCTCATCCTAAATGAACTATTTCAGTCAAGCCCACTCTACCACTTTTTACTTATCTGGTTAATAATCCGAAATGTTACCGGGGTTGACTCACGGAATTAAATTTTTCCTCTATTTTTATATCCTTTCCTGTTGTGGATGTAACTTACCTTTCTAAACTCCTTTAGAGTTAACGACTTCTATTTAGTATTGTTGGTATCTCCAGCCCCCCTCCTTTTTTTGTTTTTCTTTTAGTTATTTACTTTGTTTGTATAATTTGCTTTCATTAACTAAAAATGGAATTGGCAGCACTGGATTGTATATTACTGTATTAAGAGTACCTTTGTTTTCTTGATCTGTTACTTTTAATACTCAGGTAATGCTACAAATATTACAGGGAGTCAAATGCTTTTATAAAGTTCCTTCAGTGGTTGCCTCACTTGCGTTTTCCTACAAGATGTAAGACTGTTTATAATTAAACTTTTTTGGTCCTTCATTTGCATGCTTTTCTATCAGTCTTGGGTAAGGAGGGGTCTCTTTCCTCTCTCCCCGGCCCCACCTTCTGAGACTTATATGTGACCAGGTCACATAGATTTCTGCCTCTCTGCTTTTTTAAGTGGCAAGTTACAGCCCATCTGGATTGTGGTATTGTTCCCAGACCAAATCAAGGGTTGGACTGCTTATTCTCGCAGCCCAATAATGAGGTGCAGATGAACTGAGAAAGGAGGGAGTTTATTTCTGTAACCAGGTATGGGGAGAAAGCCTGGAAATGATCCCAAGACCAACTCAAAACTACAAAGTTTTCCAGAGCTTATTTACATTATAAGCTATATGTCTACATGTGAGTGTACATTCATCTAAAGACATAAGTGATTC hsa_mir_1266_5p-mrna_ptpn11-1 1 3 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified 6 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered ENST00000351677:r.2502_2504delinsttt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GAG TTT ENST00000351677:r.3445_3447delinsttt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GAG TTT tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range physical association physical association Fig 6 C, Suppl Fig 6 down-regulates quantity by destabilization hsa_mir_1266_5p-mrna_itch-1 1 7 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag 3' range 3' range undetermined undetermined sequence position undetermined ENST00000374864:r.4280_4282delinsttt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GAG TTT 3 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified physical association physical association Fig 6 C, Suppl Fig 6 down-regulates quantity by destabilization hsa_mir_1266_5p-mrna_tnip1-1 1 4 regulator target regulator target regulator target modulator target neutral component neutral component tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range ENST00000315050:r.2663-2665delinsttt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GAG TTT 3 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified physical association physical association Fig 6 C, Suppl Fig 6 down-regulates quantity by destabilization hsa_mir_1266_5p-mrna socs3-1 1 5 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range ENST00000330871:r.1747_1749delinsttt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GAG TTT 3 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified physical association physical association Fig 6 C, Suppl Fig 6 A down-regulates quantity by destabilization hsa_mir_1266_5p-mrna_itch-2 2 7 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag 3' range 3' range undetermined undetermined sequence position undetermined ENST00000374864:r.4280_4282delinsttt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GAG TTT 3 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified physical association physical association Fig 6 C, Suppl Fig 6 down-regulates quantity by destabilization hsa_mir_1266_5p-mrna_tnip1-2 2 4 regulator target regulator target regulator target modulator target neutral component neutral component tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range ENST00000315050:r.2663-2665delinsttt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GAG TTT 3 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified physical association physical association Fig 6 C, Suppl Fig 6 down-regulates quantity by destabilization hsa_mir_1266_5p-mrna socs3-2 2 5 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range ENST00000330871:r.1747_1749delinsttt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GAG TTT 3 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified physical association physical association Fig 6 C, Suppl Fig 6 A down-regulates quantity by destabilization hsa_mir_1266_5p-mrna_ptpn11-2 2 3 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified 6 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered ENST00000351677:r.2502_2504delinsttt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GAG TTT ENST00000351677:r.3445_3447delinsttt mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain GAG TTT tag luciferase tag luciferase tag 3' range 3' range 3' range 3' range physical association physical association Fig 6 C, Suppl Fig 6 down-regulates quantity by destabilization