DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Human TRPML1 channel structures in open and closed conformations. Human TRPML1 channel structures in open and closed conformations. Nature 2017 imex curation Schmiege P., Fine M., Blobel G., Li X. xiaochun.li@utsouthwestern.edu 13-Nov-2020: Contacted by IntAct-Help. Only protein-protein interactions imex curation human Homo sapiens Human molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column weight by staining molecular weight estimation by staining weight by staining Schmiege P., Fine M., Blobel G., Li X. xiaochun.li@utsouthwestern.edu Accepted 2020-NOV-04 AT 11:23 GMT AT 11:23 GMT by LUANA Nature 2017 Only protein-protein interactions imex curation imex curation Human TRPML1 channel structures in open and closed conformations. Human TRPML1 channel structures in open and closed conformations. Nature 2017 imex curation Schmiege P., Fine M., Blobel G., Li X. xiaochun.li@utsouthwestern.edu 13-Nov-2020: Contacted by IntAct-Help. Only protein-protein interactions imex curation human Homo sapiens Human 3d-em 3D electron microscopy 3D-EM electron tomog experimental particp experimental participant identification experimental particp Schmiege P., Fine M., Blobel G., Li X. xiaochun.li@utsouthwestern.edu Accepted 2020-NOV-04 AT 11:23 GMT AT 11:23 GMT by LUANA Nature 2017 Only protein-protein interactions imex curation imex curation mcln1_human Mucolipin-1 Mucolipidin MG-2 MCOLN1 ML4 Transient receptor potential channel mucolipin 1 MSTP080 TRPML1 protein protein human Homo sapiens Human MTAPAGPRGSETERLLTPNPGYGTQAGPSPAPPTPPEEEDLRRRLKYFFMSPCDKFRAKGRKPCKLMLQVVKILVVTVQLILFGLSNQLAVTFREENTIAFRHLFLLGYSDGADDTFAAYTREQLYQAIFHAVDQYLALPDVSLGRYAYVRGGGDPWTNGSGLALCQRYYHRGHVDPANDTFDIDPMVVTDCIQVDPPERPPPPPSDDLTLLESSSSYKNLTLKFHKLVNVTIHFRLKTINLQSLINNEIPDCYTFSVLITFDNKAHSGRIPISLETQAHIQECKHPSVFQHGDNSFRLLFDVVVILTCSLSFLLCARSLLRGFLLQNEFVGFMWRQRGRVISLWERLEFVNGWYILLVTSDVLTISGTIMKIGIEAKNLASYDVCSILLGTSTLLVWVGVIRYLTFFHNYNILIATLRVALPSVMRFCCCVAVIYLGYCFCGWIVLGPYHVKFRSLSMVSECLFSLINGDDMFVTFAAMQAQQGRSSLVWLFSQLYLYSFISLFIYMVLSLFIALITGAYDTIKHPGGAGAEESELQAYIAQCQDSPTSGKFRRGSGSACSLLCCCGRDPSEEHSLLVN 7E7691F58D01C804 mcoln1-3 2 3 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified human-293s_gnti HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient Human 293s_gnti HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient ATCC® CRL-3022 physical association physical association Fig 1, Extended Data Fig 3, Extended Data Table 1 mcoln1-4 1 3 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination weight by staining molecular weight estimation by staining weight by staining unspecified role unspecified role neutral component neutral component purified purified human-293s_gnti HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient Human 293s_gnti HEK293S GnTI -adenovirus 5 transformed, glycosylation deficient ATCC® CRL-3022 physical association physical association Extended Data Fig 2