DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase. Molecular cell 2004 imex curation Ponnuraj K., Xu Y., Macon K., Moore D., Volanakis JE., Narayana SV. narayana@uab.edu 28-Sep-2020: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Ponnuraj K., Xu Y., Macon K., Moore D., Volanakis JE., Narayana SV. narayana@uab.edu Accepted 2020-JUL-29 AT 09:55 BST AT 09:55 BST by MGT Molecular cell 2004 Only protein-protein interactions imex curation imex curation 4-guanidinobenzoic acid 4-guanidinobenzoic acid 4-Guanidino-benzoic acid p-guanidinobenzoic acid 4-carbamimidamidobenzoic acid small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) diisopropyl phosphonate DIISOPROPYL PHOSPHONATE small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) p00751-pro_0000027547 Complement factor B Bb fragment CFB BF BFD C3/C5 convertase Glycine-rich beta glycoprotein PBF2 Properdin factor B protein protein human Homo sapiens Human KIVLDPSGSMNIYLVLDGSDSIGASNFTGAKKCLVNLIEKVASYGVKPRYGLVTYATYPKIWVKVSEADSSNADWVTKQLNEINYEDHKLKSGTNTKKALQAVYSMMSWPDDVPPEGWNRTRHVIILMTDGLHNMGGDPITVIDEIRDLLYIGKDRKNPREDYLDVYVFGVGPLVNQVNINALASKKDNEQHVFKVKDMENLEDVFYQMIDESQSLSLCGMVWEHRKGTDYHKQPWQAKISVIRPSKGHESCMGAVVSEYFVLTAAHCFTVDDKEHSIKVSVGGEKRDLEIEVVLFHPNYNINGKKEAGIPEFYDYDVALIKLKNKLKYGQTIRPICLPCTEGTTRALRLPPTTTCQQQKEELLPAQDIKALFVSEEEKKLTRKEVYIKNGDKKGSCERDAQYAPGYDKVKDISEVVTPRFLCTGGVSPYADPNTCRGDSGGPLIVHKRSRFIQVGVISWGVVDVCKNQKRQKQVPAHARDFHINLFQVLPWLKEKLQDEDLGFL 260 764 531A4E7F26DB60FD cfb-nafamostat-1 1 4 unspecified role unspecified role neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P00751-PRO_0000027547:p.[Cys33Val;Phe194Cys;Asn201Cys] mutation mutation certain certain sequence position certain certain certain sequence position certain C V certain certain sequence position certain certain certain sequence position certain F C certain certain sequence position certain certain certain sequence position certain N C trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 2 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1 cfb-diisopropyl phosphonate-1 1 4 unspecified role unspecified role neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P00751-PRO_0000027547:p.[Cys33Val;Phe194Cys;Asn201Cys] mutation mutation certain certain sequence position certain certain certain sequence position certain C V certain certain sequence position certain certain certain sequence position certain F C certain certain sequence position certain certain certain sequence position certain N C trini-high_5 Trichoplusia ni cell line from eggs high_5 Insect cell line from Trichoplusia ni egg cells Invitrogen supplies this cell line. Invitrogen supply this cell line. 3 unspecified role unspecified role neutral component neutral component chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1