DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nature structural & molecular biology 2019 imex curation Cao Q., Boyer DR., Sawaya MR., Ge P., Eisenberg DS. david@mbi.ucla.edu 04-05-20: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro fluorescence fluorescence technology fluorescence predetermined predetermined participant predetermined Cao Q., Boyer DR., Sawaya MR., Ge P., Eisenberg DS. david@mbi.ucla.edu Accepted 2020-APR-06 AT 13:05 BST AT 13:05 BST by KALPANAP Nature structural & molecular biology 2019 Only protein-protein interactions imex curation imex curation Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Cryo-EM structures of four polymorphic TDP-43 amyloid cores. Nature structural & molecular biology 2019 imex curation Cao Q., Boyer DR., Sawaya MR., Ge P., Eisenberg DS. david@mbi.ucla.edu 04-05-20: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Cao Q., Boyer DR., Sawaya MR., Ge P., Eisenberg DS. david@mbi.ucla.edu Accepted 2020-APR-06 AT 13:05 BST AT 13:05 BST by KALPANAP Nature structural & molecular biology 2019 Only protein-protein interactions imex curation imex curation tadbp_human TAR DNA-binding protein 43 TARDBP TDP43 protein protein human Homo sapiens Human MSEYIRVTEDENDEPIEIPSEDDGTVLLSTVTAQFPGACGLRYRNPVSQCMRGVRLVEGILHAPDAGWGNLVYVVNYPKDNKRKMDETDASSAVKVKRAVQKTSDLIVLGLPWKTTEQDLKEYFSTFGEVLMVQVKKDLKTGHSKGFGFVRFTEYETQVKVMSQRHMIDGRWCDCKLPNSKQSQDEPLRSRKVFVGRCTEDMTEDELREFFSQYGDVMDVFIPKPFRAFAFVTFADDQIAQSLCGEDLIIKGISVHISNAEPKHNSNRQLERSGRFGGNPGGFGNQGGFGNSRGGGAGLGNNQGSNMGGGMNFGAFSINPAMMAAAQAALQSSWGMMGMLASQQNQSGPSGNNQNQGNMQREPNQAFGSGNNSYSGSNSGAAIGWGSASNAGSGSGFNGGFGSSMDSKSSGWGM DIP protein Q13148 original sequence version: 147 DIP protein Q13148 original sequence version: 114 DIP protein Q13148-1 original sequence version: 169 DIP protein Q13148-1 original sequence version: 124 8E09A1206FB4EF4A tardbp-tardbp-9 2 3 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 311-360 binding region 311-360 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 3 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 311-360 binding region 311-360 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) direct interaction direct interaction Fig 1, Table 1 tardbp-tardbp-8 2 3 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 286-331 binding region 286-331 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Q13148:p.Ala315Glu A315E mutation mutation mutation certain certain sequence position certain certain certain sequence position certain A E Tue Jun 30 16:39:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala315Glu' ecoli Escherichia coli (strain K12) 3 predetermined predetermined participant predetermined structure determination identification by structure determination identification by structure determination structure determination experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 286-331 binding region 286-331 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Q13148:p.Ala315Glu A315E mutation mutation mutation certain certain sequence position certain certain certain sequence position certain A E Tue Jun 30 20:19:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala315Glu' ecoli Escherichia coli (strain K12) direct interaction direct interaction Fig 1, Table 1 tardbp-tardbp-10 1 3 predetermined predetermined participant predetermined experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 286-331 binding region 286-331 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Q13148:p.Ala315Glu A315E mutation mutation mutation certain certain sequence position certain certain certain sequence position certain A E Tue Jun 30 19:40:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala315Glu' ecoli Escherichia coli (strain K12) 3 predetermined predetermined participant predetermined experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 286-331 binding region 286-331 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain Q13148:p.Ala315Glu A315E mutation mutation mutation certain certain sequence position certain certain certain sequence position certain A E Tue Jun 30 20:12:14 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ala315Glu' ecoli Escherichia coli (strain K12) direct interaction direct interaction Fig 4b tardbp-tardbp-11 1 3 predetermined predetermined participant predetermined experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 311-360 binding region 311-360 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 3 predetermined predetermined participant predetermined experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified 311-360 binding region 311-360 binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) direct interaction direct interaction Fig 4b