IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs. Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs. Scientific reports 2019 imex curation Jeffreys LN., Poddar H., Golovanova M., Levy CW., Girvan HM., McLean KJ., Voice MW., Leys D., Munro AW. andrew.munro@manchester.ac.uk 03-Oct-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Jeffreys LN., Poddar H., Golovanova M., Levy CW., Girvan HM., McLean KJ., Voice MW., Leys D., Munro AW. andrew.munro@manchester.ac.uk Accepted 2019-SEP-19 AT 08:12 BST AT 08:12 BST by LUANA Scientific reports 2019 Only protein-protein interactions imex curation imex curation Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs. Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs. Scientific reports 2019 imex curation Jeffreys LN., Poddar H., Golovanova M., Levy CW., Girvan HM., McLean KJ., Voice MW., Leys D., Munro AW. andrew.munro@manchester.ac.uk 03-Oct-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro uv-vis ultraviolet-visible spectroscopy uv-vis predetermined predetermined participant predetermined Jeffreys LN., Poddar H., Golovanova M., Levy CW., Girvan HM., McLean KJ., Voice MW., Leys D., Munro AW. andrew.munro@manchester.ac.uk Accepted 2019-SEP-19 AT 08:12 BST AT 08:12 BST by LUANA Scientific reports 2019 Only protein-protein interactions imex curation imex curation Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs. Novel insights into P450 BM3 interactions with FDA-approved antifungal azole drugs. Scientific reports 2019 imex curation Jeffreys LN., Poddar H., Golovanova M., Levy CW., Girvan HM., McLean KJ., Voice MW., Leys D., Munro AW. andrew.munro@manchester.ac.uk 03-Oct-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro epr electron paramagnetic resonance ESR EPR EPR ESR epr predetermined predetermined participant predetermined Jeffreys LN., Poddar H., Golovanova M., Levy CW., Girvan HM., McLean KJ., Voice MW., Leys D., Munro AW. andrew.munro@manchester.ac.uk Accepted 2019-SEP-19 AT 08:12 BST AT 08:12 BST by LUANA Scientific reports 2019 Only protein-protein interactions imex curation imex curation itraconazole itraconazole Itraconazole Itrizole (TN) Oriconazole Sporanox (TN) 2-(butan-2-yl)-4-{4-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]phenyl}-2,4-dihydro-3H-1,2,4-triazol-3-one small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) a0a1q8up87_bacme Bifunctional cytochrome P450/NADPH--P450 reductase BTA37_15100 protein protein bacme Bacillus megaterium MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKERKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFIDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSASDMPLAKMHGAFSANVVASKELQQPGSERSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLGKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHTVELEALLEKQAYKEEVLAKRLTMLELLEKYPACEMEFREFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSGFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQNEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPDVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG 44DA9514B8A4F752 f2q7t0_bacme Bifunctional cytochrome P450/NADPH--P450 reductase protein protein bacme Bacillus megaterium MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKVENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADDVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSANVVASKELQQLGSERSTRHLEIALPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLGKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMEFSEFIALLPSISPRYYSISSSPHVDEKQASITVSVVSGEAWSGYGEYKGIASNYLANLQEGDTITCFVSTPQSGFTLPKDSETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQNEGIITLHTAFSRVPNQPKTYVQHVMERDGKKLIELLDQGAHFYICGDGSQMAPDVEATLMKSYADVYEVSEADARLWLQQLEEKGRYAKDVWAG 86C2814493297D16 cpxb_bacmb Bifunctional cytochrome P450/NADPH--P450 reductase cyp102A1 Cytochrome P450(BM-3) cyp102 Cytochrome P450BM-3 Fatty acid monooxygenase Flavocytochrome P450 BM3 BG04_163 protein protein bacmb bacmb MTIKEMPQPKTFGELKNLPLLNTDKPVQALMKIADELGEIFKFEAPGRVTRYLSSQRLIKEACDESRFDKNLSQALKFVRDFAGDGLFTSWTHEKNWKKAHNILLPSFSQQAMKGYHAMMVDIAVQLVQKWERLNADEHIEVPEDMTRLTLDTIGLCGFNYRFNSFYRDQPHPFITSMVRALDEAMNKLQRANPDDPAYDENKRQFQEDIKVMNDLVDKIIADRKASGEQSDDLLTHMLNGKDPETGEPLDDENIRYQIITFLIAGHETTSGLLSFALYFLVKNPHVLQKAAEEAARVLVDPVPSYKQVKQLKYVGMVLNEALRLWPTAPAFSLYAKEDTVLGGEYPLEKGDELMVLIPQLHRDKTIWGDDVEEFRPERFENPSAIPQHAFKPFGNGQRACIGQQFALHEATLVLGMMLKHFDFEDHTNYELDIKETLTLKPEGFVVKAKSKKIPLGGIPSPSTEQSAKKVRKKAENAHNTPLLVLYGSNMGTAEGTARDLADIAMSKGFAPQVATLDSHAGNLPREGAVLIVTASYNGHPPDNAKQFVDWLDQASADEVKGVRYSVFGCGDKNWATTYQKVPAFIDETLAAKGAENIADRGEADASDDFEGTYEEWREHMWSDVAAYFNLDIENSEDNKSTLSLQFVDSAADMPLAKMHGAFSTNVVASKELQQPGSARSTRHLEIELPKEASYQEGDHLGVIPRNYEGIVNRVTARFGLDASQQIRLEAEEEKLAHLPLAKTVSVEELLQYVELQDPVTRTQLRAMAAKTVCPPHKVELEALLEKQAYKEQVLAKRLTMLELLEKYPACEMKFSEFIALLPSIRPRYYSISSSPRVDEKQASITVSVVSGEAWSGYGEYKGIASNYLAELQEGDTITCFISTPQSEFTLPKDPETPLIMVGPGTGVAPFRGFVQARKQLKEQGQSLGEAHLYFGCRSPHEDYLYQEELENAQSEGIITLHTAFSRMPNQPKTYVQHVMEQDGKKLIELLDQGAHFYICGDGSQMAPAVEATLMKSYADVHQVSEADARLWLQQLEEKGRYAKDVWAG mint B0BE61F8A2EE33D5 econazole nitrate econazole nitrate (+-)-econazole nitrate (RS)-econazole nitrate 1-(2,4-Dichloro-beta-((p-chlorobenzyl)oxy)phenethyl)imidazole nitrate Econazole mononitrate rac-econazole nitrate Spectazole 1-{2-[(4-chlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole nitrate small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) fenticonazole nitrate fenticonazole nitrate (+-)-1-(2,4-Dichloro-beta-((p-(phenylthio)benzyl)oxy)phenethyl)imidazole mononitrate alpha-(2,4-Dichlorophenyl)-beta,N-imidazolylethyl-4-phenylthiobenzyl ether nitrate fenticonazole mononitrate Lomexin rac-1-[2-(2,4-dichlorophenyl)-2-{[4-(phenylsulfanyl)benzyl]oxy}ethyl]-1H-imidazole nitrate small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) isoconazole nitrate isoconazole nitrate (+-)-isoconazole nitrate (RS)-isoconazole nitrate 1-(2,4-Dichloro-beta-(2,6-dichlorobenzyloxy)phenethyl)imidazole nitrate 1-(2-((2,6-Dichlorobenzyl)oxy)-2-(2,4-dichlorophenyl)ethyl)imidazole nitrate isoconazole mononitrate rac-isoconazole nitrate racemic isoconazole nitrate rac-1-{2-[(2,6-dichlorobenzyl)oxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole nitrate small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) sulconazole nitrate Sulconazole nitrate Sulconazole nitrate small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) tioconazole tioconazole (+-)-tioconazole (+-)-1-(2,4-Dichloro-beta-((2-chloro-3-ethenyl)oxy)phenethyl)imidazole (RS)-tioconazole 1-(2,4-Dichloro-(beta-(2-chloro-3-thenyl)oxy)phenethyl)imidazole rac-tioconazole racemic tioconazole tioconazol tioconazole tioconazolum UK 20349 UK-20,349 Vagistat-1 rac-1-{2-[(2-chloro-3-thienyl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) clotrimazole clotrimazole 1-((2-Chlorophenyl)diphenylmethyl)-1H-imidazole 1-(alpha-(2-Chlorophenyl)benzhydryl)imidazole 1-(o-Chloro-alpha,alpha-diphenylbenzyl)imidazole 1-(o-Chlorotrityl)imidazole Clotrimazole Lotrimin (TN) Mycelex (TN) 1-[(2-chlorophenyl)(diphenyl)methyl]-1H-imidazole small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) miconazole miconazole (+-)-miconazole (RS)-miconazole 1-(2,4-Dichloro-beta-((2,4-dichlorobenzyl)oxy)phenethyl)imidazole 1-[2-(2,4-Dichloro-benzyloxy)-2-(2,4-dichloro-phenyl)-ethyl]-1H-imidazole Daktarin IV Miconazole Monistat IV (TN) rac-miconazole rac-1-[2-(2,4-dichlorobenzyloxy)-2-(2,4-dichlorophenyl)ethyl]-1H-imidazole small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) sertaconazole nitrate sertaconazole nitrate (+-)-sertaconazole nitrate (RS)-sertaconazole nitrate Ertaczo rac-sertaconazole nitrate racemic sertaconazole nitrate sertaconazole mononitrate Zalain rac-1-{2-[(7-chloro-1-benzothiophen-3-yl)methoxy]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole nitrate small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) ravuconazole Ravuconazole small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) butoconazole nitrate butoconazole nitrate (+-)-1-(4-(4-chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)-1H-imidazole mononitrate (+-)-1-(4-(p-chlorophenyl)-2-((2,6-dichlorophenyl)thio)butyl)imidazole mononitrate Butoconazole nitrate nitrato de butoconazol 1-{4-(4-chlorophenyl)-2-[(2,6-dichlorophenyl)sulfanyl]butyl}-1H-imidazole nitrate small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) voriconazole voriconazole (alphaR,betaS)-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol (R-(R*,S*))-alpha-(2,4-difluorophenyl)-5-fluoro-beta-methyl-alpha-(1H-1,2,4-triazol-1-ylmethyl)-4-pyrimidineethanol VCZ Vfend voriconazol voriconazole voriconazolum (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) climbazole climbazole rac-1-(4-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethylbutan-2-one (RS)-1-(4-chlorophenoxy)-1-imidazol-1-yl-3,3-dimethylbutan-2-one 1-(p-chlorophenoxy)-1-(1H-imidazol-1-yl)-3,3-dimethyl -2-butanone climbazol climbazole Climbazolum small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) bifonazole bifonazole (+-)-bifonazole (+-)-1-(p,alpha-Diphenylbenzyl)imidazole (+-)1-([1,1'-Biphenyl]-4-ylphenylmethyl)-1H-imidazole (RS)-bifonazole 1-((4-Biphenylyl)phenylmethyl)-1H-imidazole 1-(alpha-(4-Biphenylyl)benzyl)imidazole bifonazol bifonazole bifonazolum Mycospor rac-bifonazole racemic bifonazole rac-1-[biphenyl-4-yl(phenyl)methyl]-1H-imidazole small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) ketoconazole ketoconazole Fungarest Fungoral ketoconazol ketoconazole ketoconazolum Ketoderm Ketoisdin Nizoral Panfungol Xolegel rac-1-acetyl-4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine (+-)-cis-1-acetyl-4-(p-((2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine cis-1-acetyl-4-(4-((2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazine small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) fluconazole fluconazole 2,4-difluoro-alpha,alpha-bis(1H-1,2,4-triazol-1-ylmethyl)benzyl alcohol 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL Biozole Diflucan Elazor fluconazol fluconazole fluconazolum Triflucan 2-(2,4-difluorophenyl)-1,3-bis-(1H-1,2,4-triazol-1-yl)propan-2-ol small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) posaconazole posaconazole Noxafil posaconazole Sch 56592 SCH56592 Schering 56592 2,5-anhydro-1,3,4-trideoxy-2-(2,4-difluorophenyl)-4-({4-[4-(4-{1-[(2S,3S)-2-hydroxypentan-3-yl]-5-oxo-1,5-dihydro-4H-1,2,4-triazol-4-yl}phenyl)piperazin-1-yl]phenoxy}methyl)-1-(1H-1,2,4-triazol-1-yl)-D-threo-pentitol small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) heme b Heme b small molecule small molecule chemical synthesis Chemical synthesis (Chemical synthesis) bifonazole-cyp102a1-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 16:24:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 20 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1, S1 butoconazole nitrate-cyp102a1-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 19:07:46 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 17 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1, S1 climbazole-cyp102a1-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 20:07:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 19 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 clotrimazole-cyp102a1-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 20:04:52 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 13 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-econazole nitrate-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain F V certain certain sequence position certain certain certain sequence position certain A F Tue Jun 30 19:05:20 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 8 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1, S1 cyp102a1-fenticonazole nitrate-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 18:31:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 9 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-isoconazole nitrate-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 16:56:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 10 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-ketoconazole-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 19:25:48 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 21 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-miconazole-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 17:38:42 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 14 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-sertaconazole nitrate-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain F V certain certain sequence position certain certain certain sequence position certain A F Tue Jun 30 15:48:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 15 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-sulconazole nitrate-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 18:21:40 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 11 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-tioconazole-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation increasing strength mutation increasing interaction strength mutation increasing strength certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 17:18:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 12 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 bifonazole-cyp102a1-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain F V certain certain sequence position certain certain certain sequence position certain A F Tue Jun 30 17:50:53 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 20 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Figure 3, Table S2, S3 butoconazole nitrate-cyp102a1-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain F V certain certain sequence position certain certain certain sequence position certain A F Tue Jun 30 17:16:09 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 17 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-fluconazole-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 20:09:55 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 22 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Figure 3, Table S2, S3 cyp102a1-sertaconazole nitrate-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 17:42:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 15 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Figure 3, Table S2, S3 climbazole-cyp102a1-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 20:15:13 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 19 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 clotrimazole-cyp102a1-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 18:39:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 13 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-econazole nitrate-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 19:53:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 8 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-fenticonazole nitrate-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 15:58:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 9 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-isoconazole nitrate-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 16:35:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 10 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-ketoconazole-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 17:38:40 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 21 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-fluconazole-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation causing mutation causing an interaction mutation enabling interaction mutation causing mutation causing an interaction certain certain sequence position certain certain certain sequence position certain F V certain certain sequence position certain certain certain sequence position certain A F Tue Jun 30 19:59:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 22 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-itraconazole-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation causing mutation causing an interaction mutation enabling interaction mutation causing mutation causing an interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 17:51:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 4 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-posaconazole-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation causing mutation causing an interaction mutation enabling interaction mutation causing mutation causing an interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 19:21:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 23 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-ravuconazole-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation causing mutation causing an interaction mutation enabling interaction mutation causing mutation causing an interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 17:03:00 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 16 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-voriconazole-1 2 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation causing mutation causing an interaction mutation enabling interaction mutation causing mutation causing an interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 20:03:15 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 18 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table 1, Figure 1 cyp102a1-itraconazole-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 16:41:32 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 4 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-miconazole-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 16:25:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 14 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-posaconazole-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 20:15:37 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 23 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-ravuconazole-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 20:22:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 16 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-sulconazole nitrate-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 17:06:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 11 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-tioconazole-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 18:05:41 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 12 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 cyp102a1-voriconazole-2 3 7 unspecified role unspecified role neutral component neutral component purified purified P14779:p.[Ala83Phe;Phe88Val] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain A F certain certain sequence position certain certain certain sequence position certain F V Tue Jun 30 18:06:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ala83Phe;Phe88Val]' ecoli Escherichia coli (strain K12) 18 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S2, S3 a0a1q8up87_bacme-clotrimazole-1 1 13 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) 5 unspecified role unspecified role neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 24 cofactor cofactor coenzyme neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S1 Rwork/Rfree: 0.170/0.213 Resolution (Å): 2.08 cyp102a1-fluconazole-3 1 7 cofactor cofactor coenzyme neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 22 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) 24 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S1 Rwork/Rfree: 0.162/0.200 Resolution (Å): 1.95 f2q7t0_bacme-heme b-1 1 12 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) 6 unspecified role unspecified role neutral component neutral component purified purified region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) 24 cofactor cofactor coenzyme neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S1 Rwork/Rfree: 0.189/0.215 Resolution (Å): 1.97 cyp102a1-heme b-1 1 7 unspecified role unspecified role neutral component neutral component purified purified ecoli Escherichia coli (strain K12) 18 unspecified role unspecified role neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) 24 cofactor cofactor coenzyme neutral component neutral component purified purified chemical synthesis Chemical synthesis (Chemical synthesis) direct interaction direct interaction Table S1 Rwork/Rfree: 0.159/0.199 Resolution (Å): 1.73