IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury. miR-17-3p Contributes to Exercise-Induced Cardiac Growth and Protects against Myocardial Ischemia-Reperfusion Injury. Theranostics 2016 imex curation Shi J., Bei Y., Kong X., Liu X., Lei Z., Xu T., Wang H., Xuan Q., Chen P., Xu J., Che L., Liu H., Zhong J., Sluijter JP., Li X., Rosenzweig A., Xiao J. junjiexiao@shu.edu.cn 09-May-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. mirna interference luciferase assay miRNA interference luciferase reporter assay miRNA interference luciferase assay tag luciferase tag visualisation by luciferase assay tag luciferase Shi J., Bei Y., Kong X., Liu X., Lei Z., Xu T., Wang H., Xuan Q., Chen P., Xu J., Che L., Liu H., Zhong J., Sluijter JP., Li X., Rosenzweig A., Xiao J. junjiexiao@shu.edu.cn Accepted 2019-FEB-27 AT 12:37 GMT AT 12:37 GMT by PPORRAS Theranostics 2016 Only protein-protein interactions imex curation imex curation hsa-mir-17-3p-1 microRNA 17 3p mirna micro rna micro RNA micro-RNA micro-rna mirna miRNA human Homo sapiens Human ACUGCAGUGAAGGCACUUGUAG mrna_timp3 TIMP metallopeptidase inhibitor 3 mrna messenger rna mRNA mrna human Homo sapiens Human CTGTGGCTTGCCCCAGAGCTGATCCTTGTCTTTGTCCACTTCTCAGCGAGGATGGCACTTCAGGGAGCCCTTCCCTTACTATCGCAGAGAGAGCAGGCCCTCCCCAGTCATGTCCAACCCAGAACTCTGTTTTGTTTTCTTCATAGCCCTAGCATCACAGAAAATCACCCTGTGCATTCATGGATGTCCACGGGGGCAAGGGCTTTGTGTTGCTTAACCCAGCATCCTGAACCGTGTTTGTTGAATGAATACAGAACCCCGTTTGCTCTGGGAGAGCACAGAAAACAGTCTTCTATCATATATCATAGCCAGCTGCAAACAGCAGATGGCTTCCCATATCCCAGAGAGTAAGAACCAGAGAGAGAGAGAAAGAGAGAGAGTTTGGGTCTTTCTCCTCTGTGCCTGCTCTCTCCAGAGAAACTGGAGGGGTAGCAGTTAGCATTCCCCCGCTGGTTCCACCAAGCACAGTCAAGGTCTCTAGGACATGGCCACCCCTCACCTGTGGAAGCGGTCCTGCTGGGGTGGGTGGGTGTTAGTTGGTTCTGGTTTGGGTCAGAGACACCCAGTGGCCCAGGTGGGCGTGGGGCCAGGGCGCAGACGAGAAGGGGCACGAGGGCTCCGCTCCGAGGACCCAGCGGCAAGCACCGGTCCCGGGCGCGCCCCAGCCCACCCACTCGCGTGCCCACGGCGGCATTATTCCCTATAAGGATCTGAACGATCCGGGGGCGGCCCCGCCCCGTTACCCCTTGCCCCCGGCCCCGCCCCCTTTTTGGAGGGCCGATGAGGTAATGCGGCTCTGCCATTGGTCTGAGGGGGCGGGCCCCAACAGCCCGAGGCGGGGTCCCCGGGGGCCCAGCGCTATATCACTCGGCCGCCCAGGCAGCGGCGCAGAGCGGGCAGCAGGCAGGCGGCGGGCGCTCAGACGGCTTCTCCTCCTCCTCTTGCTCCTCCAGCTCCTGCTCCTTCGCCGGGAGGCCGCCCGCCGAGTCCTGCGCCAGCGCCGAGGCAGCCTCGCTGCGCCCCATCCCGTCCCGCCGGGCACTCGGAGGGCAGCGCGCCGGAGGCCAAGGTTGCCCCGCACGGCCCGGCGGGCGAGCGAGCTCGGGCTGCAGCAGCCCCGCCGGCGGCGCGCACGGCAACTTTGGAGAGGCGAGCAGCAGCCCCGGCAGCGGCGGCAGCAGCGGCAATGACCCCTTGGCTCGGGCTCATCGTGCTCCTGGGCAGCTGGAGCCTGGGGGACTGGGGCGCCGAGGCGTGCACATGCTCGCCCAGCCACCCCCAGGACGCCTTCTGCAACTCCGACATCGTGATCCGGGCCAAGGTGGTGGGGAAGAAGCTGGTAAAGGAGGGGCCCTTCGGCACGCTGGTCTACACCATCAAGCAGATGAAGATGTACCGAGGCTTCACCAAGATGCCCCATGTGCAGTACATCCATACGGAAGCTTCCGAGAGTCTCTGTGGCCTTAAGCTGGAGGTCAACAAGTACCAGTACCTGCTGACAGGTCGCGTCTATGATGGCAAGATGTACACGGGGCTGTGCAACTTCGTGGAGAGGTGGGACCAGCTCACCCTCTCCCAGCGCAAGGGGCTGAACTATCGGTATCACCTGGGTTGTAACTGCAAGATCAAGTCCTGCTACTACCTGCCTTGCTTTGTGACTTCCAAGAACGAGTGTCTCTGGACCGACATGCTCTCCAATTTCGGTTACCCTGGCTACCAGTCCAAACACTACGCCTGCATCCGGCAGAAGGGCGGCTACTGCAGCTGGTACCGAGGATGGGCCCCCCCGGATAAAAGCATCATCAATGCCACAGACCCCTGAGCGCCAGACCCTGCCCCACCTCACTTCCCTCCCTTCCCGCTGAGCTTCCCTTGGACACTAACTCTTCCCAGATGATGACAATGAAATTAGTGCCTGTTTTCTTGCAAATTTAGCACTTGGAACATTTAAAGAAAGGTCTATGCTGTCATATGGGGTTTATTGGGAACTATCCTCCTGGCCCCACCCTGCCCCTTCTTTTTGGTTTTGACATCATTCATTTCCACCTGGGAATTTCTGGTGCCATGCCAGAAAGAATGAGGAACCTGTATTCCTCTTCTTCGTGATAATATAATCTCTATTTTTTTAGGAAAACAAAAATGAAAAACTACTCCATTTGAGGATTGTAATTCCCACCCCTCTTGCTTCTTCCCCACCTCACCATCTCCCAGACCCTCTTCCCTTTGCCCTTCTCCTCCAATACATAAAGGACACAGACAAGGAACTTGCTGAAAGGCCAACCATTTCAGGATCAGTCAAAGGCAGCAAGCAGATAGACTCAAGGTGTGTGAAAGATGTTATACACCAGGAGCTGCCACTGCATGTCCCAACCAGACTGTGTCTGTCTGTGTCTGCATGTAAGAGTGAGGGAGGGAAGGAAGGAACTACAAGAGAGTCGGAGATGATGCAGCACACACACAATTCCCCAGCCCAGTGATGCTTGTGTTGACCAGATGTTCCTGAGTCTGGAGCAAGCACCCAGGCCAGAATAACAGAGCTTTCTTAGTTGGTGAAGACTTAAACATCTGCCTGAGGTCAGGAGGCAATTTGCCTGCCTTGTACAAAAGCTCAGGTGAAAGACTGAGATGAATGTCTTTCCTCTCCCTGCCTCCCACCAGACTTCCTCCTGGAAAACGCTTTGGTAGATTTGGCCAGGAGCTTTCTTTTATGTAAATTGGATAAATACACACACCATACACTATCCACAGATATAGCCAAGTAGATTTGGGTAGAGGATACTATTTCCAGAATAGTGTTTAGCTCACCTAGGGGGATATGTTTGTATACACATTTGCATATACCCACATGGGGACATAAGCTAATTTTTTTACAGGACACAGAATTCTGTTCAATGCTGTTAAATATGCCAATAGTTTAATCTCTTCTATTTTGTTGTCGTTGCTTGTTTGAAGAAAATCATGACATTCCAAGTTGACATTTTTTTTTCATTTTAATTAAAATTTGAAATTCTGAACACCGTCAGCACCCTCTCTTCCCTATCATGGGTCATCTGACCCCTGTCCGTCTCCTTGTCCCTGCTTCATGTTTGGGGGCCTTTCTTTAACTGCCTTCCTGGCTTAGCTCAGATGGCAGATGAGAGTGTAGTCAAGGGCCTGGGCACAGGAGGGAGAGCTGCAGAGTGTCCTGCCTGCCTTGGCTGGAGGGACACCTCTCCTGGGTGTGGAGACAGCTTGGTTCCCTTTCCCTAGCTCCCTGGTGGGTGAATGCCACCTCCTGAGATCCTCACCTCTTGGAATTAAAATTGTTGGTCACTGGGGAAAGCCTGAGTTTGCAACCAGTTGTAGGGTTTCTGTTGTGTTTTTTTTTTTTTTTTTGAAATAAAACTATAATATAAATTCTCCTATTAAATAAAATTATTTTAAGTTTTAGTGTCAAAAGTGAGATGCTGAGAGTAGGTGATAATGTATATTTTACAGAGTGGGGGTTGGCAGGATGGTGACATTGAACATGATTGCTCTCTGTCTCTTTTTTCAGCTTATGGGTATTTATCTTCTATTAGTATTTGTATCTTCAGTTCATTCCACTTTAGGAAACAGAGCTGCCAATTGAAACAGAAGAAGAAAAAAAAAAAAAGCAGCAGACAACACACTGTAGAGTCTTGCACACACACAAGTGCCCAGGCAAGGTGCTTGGCAGAACCGCAGAGTGGGAAGAGAGTACCGGCATCGGGTTTCCTTGGGATCAATTTCATTACCGTGTACCTTTCCCATTGTGGTCATGCCATTTGGCAGGGGGAGAATGGGAGGCTTGGCCTTCTTTGTGAGGCAGTGTGAGCAGAAGCTGATGCCAGCATGTCACTGGTTTTGAAGGGATGAGCCCAGACTTGATGTTTTGGGATTGTCCTTATTTTAACCTCAAGGTCTCGCATGGTGGGGCCCCTGACCAACCTACACAAGTTCCCTCCCACAAGTGGACATCAGTGTCTTCTCTGTGAGGCATCTGGCCATTCGCACTCCCTGGTGTGGTCAGCCTCTCTCACACAAGGAGGAACTTGGGTGAAGGCTGAGTGTGAGGCACCTGAAGTTTCCCTGCGGAGTCGATAAATTAGCAGAACCACATCCCCATCTGTTAGGCCTTGGTGAGGAGGCCCTGGGCAAAGAAGGGTCTTTCGCAAAGCGATGTCAGAGGGCGGTTTTGAGCTTTCTATAAGCTATAGCTTTGTTTATTTCACCCGTTCACTTACTGTATAATTTAAAATCATTTATGTAGCTGAGACACTTCTGTATTTCAATCATATCATGAACATTTTATTTTGCTAAATCTTGTGTCATGTGTAGGCTGTAATATGTGTACATTGTGTTTAAGAGAAAAATGAAACCCACATGCCGCCATTTTCCTGAATCAAATTCTGCAGTGGAATGGAGAGGAAAATACTTCTAGGCAAGCAGCTAGACTGGTGAATTGGGGGAAATAGAAGGAACTAGTAACTGAGACTCCTCCAGCCTCCTCCCTATTGGAATCCCAATGGCTCCTGGAGTAGGAAAAAAGTTTAAACTACATTCATGTTCTTGTTCTGTGTCACTCGGCCCTGGGTAGTCTACCATTTACTTCACCCCAAGTCCTGCTGCCCATCCAGTTGGGAAGCCATGATTTTCCTAAGAATCCAGGGCCATGGGAGATACAATTCCAAGTTCTCGCTTCCTCCTTTGGGCATCTCTTCTGCCTCCCAATCAAGGAAGCTCCATGCTCAGGCTCTCAGCTCTCGGGCCAGTGCTCTGCTCTGTCCAGGGTAGGTAATACTGGGAGACTCCTGTCTTTTACCCTCCCCTCGTTCCAGACCTGCCTCATGGTGGCAACATGGTTCTTGAACAATTAAAGAAACAAATGACTTTTTGGAATAGCCCTGTCTAGGGCAAACTGTGGCCCCCAGGAGACACTACCCTTCCATGCCCCAGACCTCTGTCTTGCATGTGACAATTGACAATCTGGACTACCCCAAGATGGCACCCAAGTGTTTGGCTTCTGGCTACCTAAGGTTAACATGTCACTAGAGTATTTTTATGAGAGACAAACATTATAAAAATCTGATGGCAAAAGCAAAACAAAATGGAAAGTAGGGGAGGTGGATGTGACAACAACTTCCAAATTGGCTCTTTGGAGGCGAGAGGAAGGGGAGAACTTGGAGAATAGTTTTTGCTTTGGGGGTAGAGGCTTCTTAGATTCTCCCAGCATCCGCCTTTCCCTTTAGCCAGTCTGCTGTCCTGAAACCCAGAAGTGATGGAGAGAAACCAACAAGAGATCTCGAACCCTGTCTAGAAGGAATGTATTTGTTGCTAAATTTCGTAGCACTGTTTACAGTTTTCCTCCATGTTATTTATGAATTTTATATTCCGTGAATGTATATTGTCTTGTAATGTTGCATAATGTTCACTTTTTATAGTGTGTCCTTTATTCTAAACAGTAAAGTGGTTTTATTTCTATCACAAAAAAAAAAA hsa_mir_17_3p_1-mrna_timp3-1 1 2 predetermined predetermined participant predetermined tag luciferase tag visualisation by luciferase assay tag luciferase regulator regulator modulator regulator neutral component neutral component engineered engineered purified purified 3 regulator target regulator target regulator target modulator target neutral component neutral component over-expressed over expressed level over-expressed living cell living cell engineered engineered tag luciferase tag luciferase tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined r.3173_3178delinsgacgtc mutation decreasing mutation decreasing interaction hotspot hotspot mutation decreasing certain certain sequence position certain certain certain sequence position certain CTGCAG GACGTC physical association physical association fig 3 a down-regulates quantity by destabilization