UniProt UniProt http://www.uniprot.org Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Frontiers in molecular neuroscience 2016 imex curation Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. fret fluorescent resonance energy transfer FRET RET FRET analysis FRET RET FRET analysis fret tag fluorescence tag visualisation by fluorescence tag fluorescence Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. Source of tagged proteins taken from work of contributing authors. nadia.canu@uniroma2.it Accepted 2019-JUL-08 AT 09:01 BST AT 09:01 BST by LIVIAP Frontiers in molecular neuroscience 2016 Only protein-protein interactions imex curation imex curation Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Frontiers in molecular neuroscience 2016 imex curation Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 bifc bimolecular fluorescence complementation bifc tag fluorescence tag visualisation by fluorescence tag fluorescence Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it Accepted 2019-JUL-08 AT 09:01 BST AT 09:01 BST by LIVIAP Frontiers in molecular neuroscience 2016 Only protein-protein interactions imex curation imex curation Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Frontiers in molecular neuroscience 2016 imex curation Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation rat-neuron Rattus norvegicus neuronal cell neuron Neuron [Neuronal cell; Neural cell confocal microscopy confocal microscopy immunostaining immunostaining Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it Accepted 2019-JUL-08 AT 09:01 BST AT 09:01 BST by LIVIAP Frontiers in molecular neuroscience 2016 Only protein-protein interactions imex curation imex curation Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Frontiers in molecular neuroscience 2016 imex curation Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation rat-neuron Rattus norvegicus neuronal cell neuron Neuron [Neuronal cell; Neural cell pla proximity ligation assay pELISA pELISA PLA antibody detection identification by antibody antibody detection Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it Accepted 2019-JUL-08 AT 09:01 BST AT 09:01 BST by LIVIAP Frontiers in molecular neuroscience 2016 Only protein-protein interactions imex curation imex curation Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Frontiers in molecular neuroscience 2016 imex curation Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation mouse-nih_3t3 Mus musculus Swiss NIH 3t3 embryo fibroblast cells nih_3t3 Mouse Swiss NIH embryo contact inhibited fibroblast cells bifc bimolecular fluorescence complementation bifc tag fluorescence tag visualisation by fluorescence tag fluorescence Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it Accepted 2019-JUL-08 AT 09:01 BST AT 09:01 BST by LIVIAP Frontiers in molecular neuroscience 2016 Only protein-protein interactions imex curation imex curation Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Frontiers in molecular neuroscience 2016 imex curation Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. bifc bimolecular fluorescence complementation bifc tag fluorescence tag visualisation by fluorescence tag fluorescence Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it Accepted 2019-JUL-08 AT 09:01 BST AT 09:01 BST by LIVIAP Frontiers in molecular neuroscience 2016 Only protein-protein interactions imex curation imex curation Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Association of TrkA and APP Is Promoted by NGF and Reduced by Cell Death-Promoting Agents. Frontiers in molecular neuroscience 2016 imex curation Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293 Homo sapiens transformed primary embryonal kidney cells Human 293 Transformed human primary embryonal kidney cells. The Cell type named 293 is synonymous with HEK-293. anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Canu N., Pagano I., La Rosa LR., Pellegrino M., Ciotti MT., Mercanti D., Moretti F., Sposato V., Triaca V., Petrella C., Maruyama IN., Levi A., Calissano P. nadia.canu@uniroma2.it Accepted 2019-JUL-08 AT 09:01 BST AT 09:01 BST by LIVIAP Frontiers in molecular neuroscience 2016 Only protein-protein interactions imex curation imex curation p05067-4 Amyloid-beta precursor protein APP A4 AD1 ABPP Alzheimer disease amyloid protein Cerebral vascular amyloid peptide PreA4 Protease nexin-II APPI PreA4 695 Amyloid precursor protein Amyloid-beta A4 protein Alzheimer disease amyloid A4 protein homolog Amyloid-beta (A4) precursor protein protein protein human Homo sapiens Human MLPGLALLLLAAWTARALEVPTDGNAGLLAEPQIAMFCGRLNMHMNVQNGKWDSDPSGTKTCIDTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHPHFVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDNVDSADAEEDDSDVWWGGADTDYADGSEDKVVEVAEEEEVAEVEEEEADDDEDDEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVRVPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPRHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHSFGADSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN DIP protein P05067-4 original sequence version: 183 DIP protein P05067-4 original sequence version: 198 DIP protein P05067-4 original sequence version: 224 A major isoform. 4F6EA0139F969D56 ntrk1_human High affinity nerve growth factor receptor NTRK1 TRK Neurotrophic tyrosine kinase receptor type 1 TRK1-transforming tyrosine kinase protein p140-TrkA MTC TRKA Tropomyosin-related kinase A Tyrosine kinase receptor Tyrosine kinase receptor A gp140trk protein protein human Homo sapiens Human MLRGGRRGQLGWHSWAAGPGSLLAWLILASAGAAPCPDACCPHGSSGLRCTRDGALDSLHHLPGAENLTELYIENQQHLQHLELRDLRGLGELRNLTIVKSGLRFVAPDAFHFTPRLSRLNLSFNALESLSWKTVQGLSLQELVLSGNPLHCSCALRWLQRWEEEGLGGVPEQKLQCHGQGPLAHMPNASCGVPTLKVQVPNASVDVGDDVLLRCQVEGRGLEQAGWILTELEQSATVMKSGGLPSLGLTLANVTSDLNRKNVTCWAENDVGRAEVSVQVNVSFPASVQLHTAVEMHHWCIPFSVDGQPAPSLRWLFNGSVLNETSFIFTEFLEPAANETVRHGCLRLNQPTHVNNGNYTLLAANPFGQASASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSGDPVEKKDETPFGVSVAVGLAVFACLFLSTLLLVLNKCGRRNKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIIENPQYFSDACVHHIKRRDIVLKWELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESARQDFQREAELLTMLQHQHIVRFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRACPPEVYAIMRGCWQREPQQRHSIKDVHARLQALAQAPPVYLDVLG DIP protein P04629 original sequence version: 203 DIP protein P04629 original sequence version: 192 6C15C721E336B601 a4_rat Amyloid-beta precursor protein Alzheimer disease amyloid A4 protein homolog ABPP Amyloidogenic glycoprotein App Amyloid precursor protein A4 AD1 Alzheimer disease amyloid protein Amyloid-beta (A4) precursor protein Amyloid-beta A4 protein protein protein rat Rattus norvegicus (Rat) Rat MLPSLALLLLAAWTVRALEVPTDGNAGLLAEPQIAMFCGKLNMHMNVQNGKWESDPSGTKTCIGTKEGILQYCQEVYPELQITNVVEANQPVTIQNWCKRGRKQCKTHTHIVIPYRCLVGEFVSDALLVPDKCKFLHQERMDVCETHLHWHTVAKETCSEKSTNLHDYGMLLPCGIDKFRGVEFVCCPLAEESDSIDSADAEEDDSDVWWGGADTDYADGGEDKVVEVAEEEEVADVEEEEAEDDEDVEDGDEVEEEAEEPYEEATERTTSIATTTTTTTESVEEVVREVCSEQAETGPCRAMISRWYFDVTEGKCAPFFYGGCGGNRNNFDTEEYCMAVCGSVSSQSLLKTTSEPLPQDPVKLPTTAASTPDAVDKYLETPGDENEHAHFQKAKERLEAKHRERMSQVMREWEEAERQAKNLPKADKKAVIQHFQEKVESLEQEAANERQQLVETHMARVEAMLNDRRRLALENYITALQAVPPRPHHVFNMLKKYVRAEQKDRQHTLKHFEHVRMVDPKKAAQIRSQVMTHLRVIYERMNQSLSLLYNVPAVAEEIQDEVDELLQKEQNYSDDVLANMISEPRISYGNDALMPSLTETKTTVELLPVNGEFSLDDLQPWHPFGVDSVPANTENEVEPVDARPAADRGLTTRPGSGLTNIKTEEISEVKMDAEFGHDSGFEVRHQKLVFFAEDVGSNKGAIIGLMVGGVVIATVIVITLVMLKKKQYTSIHHGVVEVDAAVTPEERHLSKMQQNGYENPTYKFFEQMQN DIP protein P08592 original sequence version: 136 C26C9D6BB2D929A7 ntrk3_rat NT-3 growth factor receptor Ntrk3 Trkc Neurotrophic tyrosine kinase receptor type 3 TrkC tyrosine kinase GP145-TrkC protein protein rat Rattus norvegicus (Rat) Rat MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQDSGNSNGNASINITDISRNITSIHIENWRGLHTLNAVDMELYTGLQKLTIKNSGLRNIQPRAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELRLEQNFFNCSCDIRWMQLWQEQGEARLDSQSLYCISADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALTVYYPPRVVSLVEPEVRLEHCIEFVVRGNPTPTLHWLYNGQPLRESKIIHMDYYQEGEVSEGCLLFNKPTHYNNGNYTLIAKNALGTANQTINGHFLKEPFPESTDFFDFESDASPTPPITVTHKPEEDTFGVSIAVGLAAFACVLLVVLFIMINKYGRRSKFGMKGPVAVISGEEDSASPLHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYREGPYQKGPFSVSWQQQRLAASAASTLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG DIP protein Q03351 original sequence version: 79 DIP protein Q03351 original sequence version: 93 mint Receptor for neurotrophin-3 (NTF3). This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLCG1. TrkC isoforms containing insertions within the kinase domain can autophosphorylate in response to NT-3, but cannot mediate downstream phenotypic responses A202E993E208F636 ntrk2_rat BDNF/NT-3 growth factors receptor Ntrk2 Trkb Neurotrophic tyrosine kinase receptor type 2 TrkB tyrosine kinase protein protein rat Rattus norvegicus (Rat) Rat MSPWPRWHGPAMARLWGLCLLVLGFWRASLACPMSCKCSTTRIWCTEPSPGIVAFPRLEPNSIDPENITEILIANQKRLEIINEDDVEAYVGLKNLTIVDSGLKFVAYKAFLKNGNLRHINFTRNKLTSLSRRHFRHLDLSDLILTGNPFTCSCDIMWLKTLQETKSSPDTQDLYCLNESSKNTPLANLQIPNCGLPSARLAAPNLTVEEGKSVTISCSVGGDPLPTLYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVRGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLMAKNEYGKDERQISAHFMGRPGVDYETNPNYPEVLYEDWTTPTDIGDTTNKSNEIPSTDVADQTNREHLSVYAVVVIASVVGFCLLVMLLLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTCPQEVYELMLGCWQREPHTRKNIKNIHTLLQNLAKASPVYLDILG DIP protein Q63604 original sequence version: 141 DIP protein Q63604 original sequence version: 69 DIP protein Q63604 original sequence version: 133 DIP protein Q63604 original sequence version: 104 DIP protein Q63604-1 original sequence version: 105 Receptor for brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5 but not nerve growth factor (NGF). Involved in the development and/or maintenance of the nervous system. This is a tyrosine-protein kinase receptor. Known substrates for the TRK receptors are SHC1, PI-3 kinase, and PLC-gamma-1 mint 0DDACDA212CDAA0E ntrk1_rat High affinity nerve growth factor receptor Neurotrophic tyrosine kinase receptor type 1 p140-TrkA Slow nerve growth factor receptor Ntrk1 Trk Trka protein protein rat Rattus norvegicus (Rat) Rat MLRGQRHGQLGWHRPAAGLGGLVTSLMLACACAASCRETCCPVGPSGLRCTRAGTLNTLRGLRGAGNLTELYVENQRDLQRLEFEDLQGLGELRSLTIVKSGLRFVAPDAFHFTPRLSHLNLSSNALESLSWKTVQGLSLQDLTLSGNPLHCSCALLWLQRWEQEDLCGVYTQKLQGSGSGDQFLPLGHNNSCGVPSVKIQMPNDSVEVGDDVFLQCQVEGQALQQADWILTELEGTATMKKSGDLPSLGLTLVNVTSDLNKKNVTCWAENDVGRAEVSVQVSVSFPASVHLGKAVEQHHWCIPFSVDGQPAPSLRWFFNGSVLNETSFIFTQFLESALTNETMRHGCLRLNQPTHVNNGNYTLLAANPYGQAAASIMAAFMDNPFEFNPEDPIPVSFSPVDTNSTSRDPVEKKDETPFGVSVAVGLAVSAALFLSALLLVLNKCGQRSKFGINRPAVLAPEDGLAMSLHFMTLGGSSLSPTEGKGSGLQGHIMENPQYFSDTCVHHIKRQDIILKWELGEGAFGKVFLAECYNLLNDQDKMLVAVKALKETSENARQDFHREAELLTMLQHQHIVRFFGVCTEGGPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGEDVAPGPLGLGQLLAVASQVAAGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIRWMPPESILYRKFSTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIECITQGRELERPRACPPDVYAIMRGCWQREPQQRLSMKDVHARLQALAQAPPSYLDVLG DIP protein P35739 original sequence version: 73 DIP protein P35739 original sequence version: 108 D564E8801E8978F8 app-ntrk1-1 7 9 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P04629:p.Lys538Ala mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain K A Tue Jun 30 17:24:05 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys538Ala' 8 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain P05067-4:p.Tyr682Gly mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain Y G Tue Jun 30 19:58:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr682Gly' P05067-4:p.[Lys595_Met596delinsAsnLeu;Val642Phe] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain KM NL certain certain sequence position certain certain certain sequence position certain V F Fri Feb 01 16:54:48 GMT 2019 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys595Asn;Met596Leu;Val642Phe]' Tue Jun 30 17:20:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys595_Met596delinsAsnLeu;Val642Phe]' physical association physical association Fig. 1B, Fig. 2F, Supp. Fig. 2 ntrk1-app-1 7 9 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 8 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed physical association physical association Fig. 1D The presence or absence of divalent cations had no effect on this interaction ntrk1-app-2 1 13 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept over-expressed over expressed level over-expressed region yfp tag yellow fluorescent protein tag YFP yellow fluorescent protein yellow fluorescent protein YFP yfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 8 unspecified role unspecified role fluorescence donor fluorescence donor over-expressed over expressed level over-expressed region cfp tag cyan fluorescent protein tag CFP cyan fluorescent protein cyan fluorescent protein CFP cfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined proximity proximity close-contact colocalization neighbourhood interaction Fig. 2A ntrk1-app-3 6 9 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed c-terminal venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed P05067-4:p.Tyr682Gly mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain Y G Fri Feb 01 16:42:59 GMT 2019 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr682Gly' Tue Jun 30 16:12:14 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr682Gly' c-terminal venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range P05067-4:p.[Lys595_Met596delinsAsnLeu;Val642Phe] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain KM NL certain certain sequence position certain certain certain sequence position certain V F Fri Feb 01 17:02:25 GMT 2019 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys595Asn;Met596Leu;Val642Phe]' Tue Jun 30 17:09:08 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys595_Met596delinsAsnLeu;Val642Phe]' region required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain physical association physical association Fig. 2C-E, 3A 3D-G, Supp. Fig. 5 ntrk1-ntrk1-2 6 9 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed c-terminal venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range 9 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed c-terminal venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association Fig. 2C, 3A app-ntrk1-2 6 9 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed c-terminal venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed P05067-4:p.Tyr682Gly mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain Y G Fri Feb 01 16:13:07 GMT 2019 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr682Gly' Tue Jun 30 15:46:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr682Gly' c-terminal venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range P05067-4:p.[Lys595_Met596delinsAsnLeu;Val642Phe] mutation with no effect mutation with no effect mutation with no effect mutation not affecting interaction certain certain sequence position certain certain certain sequence position certain KM NL certain certain sequence position certain certain certain sequence position certain V F Fri Feb 01 16:24:45 GMT 2019 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys595Asn;Met596Leu;Val642Phe]' Tue Jun 30 19:37:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys595_Met596delinsAsnLeu;Val642Phe]' physical association physical association Fig. 2C-E, 3A 3H-J, Supp. Fig. 5 app-ntrk1-3 6 9 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed c-terminal venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed c-terminal venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association Fig. 4A, 4B Supp. Fig. 3 NGFR (P08138) SHC3 (Q92529) APBA2 (Q99767) app-ntrk1-4 5 9 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed c-terminal venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed P05067-4:p.Tyr682Gly mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain Y G Tue Jun 30 16:55:03 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr682Gly' c-terminal venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range physical association physical association Fig. 4D app-ntrk1-5 2 9 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed c-terminal venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range 8 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed c-terminal venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range P05067-4:p.Tyr682Gly mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain Y G Thu Jul 11 17:28:53 BST 2019 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Tyr682Gly]' Tue Jun 30 18:29:46 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr682Gly' physical association physical association Fig. 4D app-ntrk1-6 4 10 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level c-terminal venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range 13 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level c-terminal venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range proximity proximity close-contact colocalization neighbourhood interaction Fig. 5B, 5C, 6A, 6B, 6D, 6E, 7A, 7B, Supp Fig. 4, 7 NGF (P25427) Brefeldin A (CHEBI:48080) Amyloid-beta 40 (P08592-PRO_000000016) Staurosporine (CHEBI:15738) Rapamycin Amyloid-beta 40 (P08592-PRO_0000000163) app-ntrk2-1 4 12 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level c-terminal venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range 10 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level c-terminal venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range proximity proximity close-contact colocalization neighbourhood interaction Fig. 5D app-ntrk3-1 4 11 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level c-terminal venus-c venus c-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range 10 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level c-terminal venus-n venus n-terminal fragment c-term range C-terminal range c-term range c-term range C-terminal range c-term range proximity proximity close-contact colocalization neighbourhood interaction Fig. 5D app-ntrk1-7 3 10 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level 13 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level colocalization colocalization Fig. 5A