IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Cell Discovery 2014 imex curation Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 tap tandem affinity purification TAP TAP tap sequence tag sequence tag identification sequence tag Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu Accepted 2019-JUN-03 AT 09:11 BST AT 09:11 BST by ORCHARD Cell Discovery 2014 Only protein-protein interactions imex curation imex curation Altered cell line used, and added a "Comment". EBI-21273895 - I have added Table 2 to Fig. Legend, as suggested by you in Expt-4 comments.; I have added "Table 2" to Fig legend in Expt 1 for EBI-21273895. EBI-21277288 (with myc-tag) Fig. legend has been altered to "Table 4" where it should have been originally. Something went wrong here;I have reannotated Table 4 results. EBI-21277196/EBI-21277179/EBI-21277240:- I have added a comment to each, but not sure if EBI-21277240 should be included as an interaction, as when ADRA1D–Delta PDZ construct is present, it is not detected by MS according to the results! - it is not listed in Table 3 for bottom interaction. Maybe the comment in (EBI-21277196) is enough?; added EBI-21445776; added PPFIBP1 (lipb1_human) as the missing interactor and duplicate lipa1 removed. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Cell Discovery 2014 imex curation Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-a375 Human malignant melanoma a375 Human malignant melanoma ATCC catalog # CRL-1872 tap tandem affinity purification TAP TAP tap sequence tag sequence tag identification sequence tag Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu Accepted 2019-JUN-03 AT 09:11 BST AT 09:11 BST by ORCHARD Cell Discovery 2014 Only protein-protein interactions imex curation imex curation Altered cell line used, and added a "Comment". EBI-21273895 - I have added Table 2 to Fig. Legend, as suggested by you in Expt-4 comments.; I have added "Table 2" to Fig legend in Expt 1 for EBI-21273895. EBI-21277288 (with myc-tag) Fig. legend has been altered to "Table 4" where it should have been originally. Something went wrong here;I have reannotated Table 4 results. EBI-21277196/EBI-21277179/EBI-21277240:- I have added a comment to each, but not sure if EBI-21277240 should be included as an interaction, as when ADRA1D–Delta PDZ construct is present, it is not detected by MS according to the results! - it is not listed in Table 3 for bottom interaction. Maybe the comment in (EBI-21277196) is enough?; added EBI-21445776; added PPFIBP1 (lipb1_human) as the missing interactor and duplicate lipa1 removed. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Cell Discovery 2014 imex curation Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu Accepted 2019-JUN-03 AT 09:11 BST AT 09:11 BST by ORCHARD Cell Discovery 2014 Only protein-protein interactions imex curation imex curation Altered cell line used, and added a "Comment". EBI-21273895 - I have added Table 2 to Fig. Legend, as suggested by you in Expt-4 comments.; I have added "Table 2" to Fig legend in Expt 1 for EBI-21273895. EBI-21277288 (with myc-tag) Fig. legend has been altered to "Table 4" where it should have been originally. Something went wrong here;I have reannotated Table 4 results. EBI-21277196/EBI-21277179/EBI-21277240:- I have added a comment to each, but not sure if EBI-21277240 should be included as an interaction, as when ADRA1D–Delta PDZ construct is present, it is not detected by MS according to the results! - it is not listed in Table 3 for bottom interaction. Maybe the comment in (EBI-21277196) is enough?; added EBI-21445776; added PPFIBP1 (lipb1_human) as the missing interactor and duplicate lipa1 removed. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Cell Discovery 2014 imex curation Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. tap tandem affinity purification TAP TAP tap sequence tag sequence tag identification sequence tag Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. When no cell line is explicitly stated as being the experimental host, is has been assumed to be HEK 293T cells as these seem to have been used by default throughout the work. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu Accepted 2019-JUN-03 AT 09:11 BST AT 09:11 BST by ORCHARD Cell Discovery 2014 Only protein-protein interactions imex curation imex curation Altered cell line used, and added a "Comment". EBI-21273895 - I have added Table 2 to Fig. Legend, as suggested by you in Expt-4 comments.; I have added "Table 2" to Fig legend in Expt 1 for EBI-21273895. EBI-21277288 (with myc-tag) Fig. legend has been altered to "Table 4" where it should have been originally. Something went wrong here;I have reannotated Table 4 results. EBI-21277196/EBI-21277179/EBI-21277240:- I have added a comment to each, but not sure if EBI-21277240 should be included as an interaction, as when ADRA1D–Delta PDZ construct is present, it is not detected by MS according to the results! - it is not listed in Table 3 for bottom interaction. Maybe the comment in (EBI-21277196) is enough?; added EBI-21445776; added PPFIBP1 (lipb1_human) as the missing interactor and duplicate lipa1 removed. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Cell Discovery 2014 imex curation Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-a_549 Homo sapiens Caucasian lung carcinoma cell line a_549 Human Caucasian lung carcinoma tap tandem affinity purification TAP TAP tap sequence tag sequence tag identification sequence tag Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu Accepted 2019-JUN-03 AT 09:11 BST AT 09:11 BST by ORCHARD Cell Discovery 2014 Only protein-protein interactions imex curation imex curation Altered cell line used, and added a "Comment". EBI-21273895 - I have added Table 2 to Fig. Legend, as suggested by you in Expt-4 comments.; I have added "Table 2" to Fig legend in Expt 1 for EBI-21273895. EBI-21277288 (with myc-tag) Fig. legend has been altered to "Table 4" where it should have been originally. Something went wrong here;I have reannotated Table 4 results. EBI-21277196/EBI-21277179/EBI-21277240:- I have added a comment to each, but not sure if EBI-21277240 should be included as an interaction, as when ADRA1D–Delta PDZ construct is present, it is not detected by MS according to the results! - it is not listed in Table 3 for bottom interaction. Maybe the comment in (EBI-21277196) is enough?; added EBI-21445776; added PPFIBP1 (lipb1_human) as the missing interactor and duplicate lipa1 removed. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Cell Discovery 2014 imex curation Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-mcf7 Homo sapiens mammary carcinoma cells mcf7 mammary carcinoma cells tap tandem affinity purification TAP TAP tap sequence tag sequence tag identification sequence tag Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu Accepted 2019-JUN-03 AT 09:11 BST AT 09:11 BST by ORCHARD Cell Discovery 2014 Only protein-protein interactions imex curation imex curation Altered cell line used, and added a "Comment". EBI-21273895 - I have added Table 2 to Fig. Legend, as suggested by you in Expt-4 comments.; I have added "Table 2" to Fig legend in Expt 1 for EBI-21273895. EBI-21277288 (with myc-tag) Fig. legend has been altered to "Table 4" where it should have been originally. Something went wrong here;I have reannotated Table 4 results. EBI-21277196/EBI-21277179/EBI-21277240:- I have added a comment to each, but not sure if EBI-21277240 should be included as an interaction, as when ADRA1D–Delta PDZ construct is present, it is not detected by MS according to the results! - it is not listed in Table 3 for bottom interaction. Maybe the comment in (EBI-21277196) is enough?; added EBI-21445776; added PPFIBP1 (lipb1_human) as the missing interactor and duplicate lipa1 removed. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Cell Discovery 2014 imex curation Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-293t Homo sapiens 293 cells transformed with SV40 large T antigen 293t 293 cells expressing SV40 large T antigen. The original designation of this cell line was 293tsA1609neo. It is not in Cabri,ATCC or HyperCLDB. pull down pull down western blot western blot Immuno blot Immuno blot Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. Results have been entered as found in the cell line 293T; however no cell line is stated. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu Accepted 2019-JUN-03 AT 09:11 BST AT 09:11 BST by ORCHARD Cell Discovery 2014 Only protein-protein interactions imex curation imex curation Altered cell line used, and added a "Comment". EBI-21273895 - I have added Table 2 to Fig. Legend, as suggested by you in Expt-4 comments.; I have added "Table 2" to Fig legend in Expt 1 for EBI-21273895. EBI-21277288 (with myc-tag) Fig. legend has been altered to "Table 4" where it should have been originally. Something went wrong here;I have reannotated Table 4 results. EBI-21277196/EBI-21277179/EBI-21277240:- I have added a comment to each, but not sure if EBI-21277240 should be included as an interaction, as when ADRA1D–Delta PDZ construct is present, it is not detected by MS according to the results! - it is not listed in Table 3 for bottom interaction. Maybe the comment in (EBI-21277196) is enough?; added EBI-21445776; added PPFIBP1 (lipb1_human) as the missing interactor and duplicate lipa1 removed. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Individual protomers of a G protein-coupled receptor dimer integrate distinct functional modules. Cell Discovery 2014 imex curation Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu 25-Jul-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-sw480 Human SW480 adenocarcinoma cell line sw480 SW480- human primary colorectal adenocarcinoma cell line There is a G -> A mutation in codon 273 of the p53 gene resulting in an Arg -> His substitution and a C -> T mutation in codon 309 resulting in a Pro -> Ser substitution. http://www.atcc.org/ATCCAdvancedCatalogSearch/ProductDetails/tabid/452/Default.aspx?ATCCNum=CCL-228&Template=cellBiology tap tandem affinity purification TAP TAP tap sequence tag sequence tag identification sequence tag Camp ND., Lee KS., Wacker-Mhyre JL., Kountz TS., Park JM., Harris DA., Estrada M., Stewart A., Wolf-Yadlin A., Hague C. NO reply to email. Email retained here for info:- [depending on any authors reply Figures 2A/B may need adding to Expt 2? Cell lines also needed for figs 1a/c and Fig 3.Methods for figure 2A and 3A - same as 1A?] Email sent 18/3/19:- 1] Which CELL LINE(S) were used to produce the results in TABLE 1, Figure 1 A/C, Figure 2A/B and Figure 3? 2] For results shown in Figure 2A and Figure 3 - were these also produced by Affinity Purification? (similarly as in Figure 1A?) If not, could you clarify the methods used? 3] In Figure 3B you describe a "TAP–ADRA1D-ΔPDZ" (TAP-–ADRA1D-Delta_PDZ)construct. Can you confirm this construct is lacking the C-terminal 4 amino acids "TDI" -- amino acids 569-572, Uniprot P25100?(deduced from Reference 8) If this is not the correct deletion, what was it? GPCR cDNAs were subcloned into pGlue which has an N terminal TAP tag comprising strep, HA and CBP tags - Addgene (Plasmid #15100) -see Methods section. The Delta+PDZ construct as used in figure 3 has been taken to be missing the C-terminal four amino acids. See Ref 8 (PMID:17995450) Table 4. chague@uw.edu Accepted 2019-JUN-03 AT 09:11 BST AT 09:11 BST by ORCHARD Cell Discovery 2014 Only protein-protein interactions imex curation imex curation Altered cell line used, and added a "Comment". EBI-21273895 - I have added Table 2 to Fig. Legend, as suggested by you in Expt-4 comments.; I have added "Table 2" to Fig legend in Expt 1 for EBI-21273895. EBI-21277288 (with myc-tag) Fig. legend has been altered to "Table 4" where it should have been originally. Something went wrong here;I have reannotated Table 4 results. EBI-21277196/EBI-21277179/EBI-21277240:- I have added a comment to each, but not sure if EBI-21277240 should be included as an interaction, as when ADRA1D–Delta PDZ construct is present, it is not detected by MS according to the results! - it is not listed in Table 3 for bottom interaction. Maybe the comment in (EBI-21277196) is enough?; added EBI-21445776; added PPFIBP1 (lipb1_human) as the missing interactor and duplicate lipa1 removed. snta1_human Alpha-1-syntrophin 59 kDa dystrophin-associated protein A1 acidic component 1 Pro-TGF-alpha cytoplasmic domain-interacting protein 1 Syntrophin-1 SNTA1 SNT1 protein protein human Homo sapiens Human MASGRRAPRTGLLELRAGAGSGAGGERWQRVLLSLAEDVLTVSPADGDPGPEPGAPREQEPAQLNGAAEPGAGPPQLPEALLLQRRRVTVRKADAGGLGISIKGGRENKMPILISKIFKGLAADQTEALFVGDAILSVNGEDLSSATHDEAVQVLKKTGKEVVLEVKYMKDVSPYFKNSTGGTSVGWDSPPASPLQRQPSSPGPTPRNFSEAKHMSLKMAYVSKRCTPNDPEPRYLEICSADGQDTLFLRAKDEASARSWATAIQAQVNTLTPRVKDELQALLAATSTAGSQDIKQIGWLTEQLPSGGTAPTLALLTEKELLLYLSLPETREALSRPARTAPLIATRLVHSGPSKGSVPYDAELSFALRTGTRHGVDTHLFSVESPQELAAWTRQLVDGCHRAAEGVQEVSTACTWNGRPCSLSVHIDKGFTLWAAEPGAARAVLLRQPFEKLQMSSDDGASLLFLDFGGAEGEIQLDLHSCPKTIVFIIHSFLSAKVTRLGLLA DIP protein Q13424 original sequence version: 78 C07DA5F21C775CF8 dmd_human Dystrophin DMD protein protein human Homo sapiens Human MLWWEEVEDCYEREDVQKKTFTKWVNAQFSKFGKQHIENLFSDLQDGRRLLDLLEGLTGQKLPKEKGSTRVHALNNVNKALRVLQNNNVDLVNIGSTDIVDGNHKLTLGLIWNIILHWQVKNVMKNIMAGLQQTNSEKILLSWVRQSTRNYPQVNVINFTTSWSDGLALNALIHSHRPDLFDWNSVVCQQSATQRLEHAFNIARYQLGIEKLLDPEDVDTTYPDKKSILMYITSLFQVLPQQVSIEAIQEVEMLPRPPKVTKEEHFQLHHQMHYSQQITVSLAQGYERTSSPKPRFKSYAYTQAAYVTTSDPTRSPFPSQHLEAPEDKSFGSSLMESEVNLDRYQTALEEVLSWLLSAEDTLQAQGEISNDVEVVKDQFHTHEGYMMDLTAHQGRVGNILQLGSKLIGTGKLSEDEETEVQEQMNLLNSRWECLRVASMEKQSNLHRVLMDLQNQKLKELNDWLTKTEERTRKMEEEPLGPDLEDLKRQVQQHKVLQEDLEQEQVRVNSLTHMVVVVDESSGDHATAALEEQLKVLGDRWANICRWTEDRWVLLQDILLKWQRLTEEQCLFSAWLSEKEDAVNKIHTTGFKDQNEMLSSLQKLAVLKADLEKKKQSMGKLYSLKQDLLSTLKNKSVTQKTEAWLDNFARCWDNLVQKLEKSTAQISQAVTTTQPSLTQTTVMETVTTVTTREQILVKHAQEELPPPPPQKKRQITVDSEIRKRLDVDITELHSWITRSEAVLQSPEFAIFRKEGNFSDLKEKVNAIEREKAEKFRKLQDASRSAQALVEQMVNEGVNADSIKQASEQLNSRWIEFCQLLSERLNWLEYQNNIIAFYNQLQQLEQMTTTAENWLKIQPTTPSEPTAIKSQLKICKDEVNRLSDLQPQIERLKIQSIALKEKGQGPMFLDADFVAFTNHFKQVFSDVQAREKELQTIFDTLPPMRYQETMSAIRTWVQQSETKLSIPQLSVTDYEIMEQRLGELQALQSSLQEQQSGLYYLSTTVKEMSKKAPSEISRKYQSEFEEIEGRWKKLSSQLVEHCQKLEEQMNKLRKIQNHIQTLKKWMAEVDVFLKEEWPALGDSEILKKQLKQCRLLVSDIQTIQPSLNSVNEGGQKIKNEAEPEFASRLETELKELNTQWDHMCQQVYARKEALKGGLEKTVSLQKDLSEMHEWMTQAEEEYLERDFEYKTPDELQKAVEEMKRAKEEAQQKEAKVKLLTESVNSVIAQAPPVAQEALKKELETLTTNYQWLCTRLNGKCKTLEEVWACWHELLSYLEKANKWLNEVEFKLKTTENIPGGAEEISEVLDSLENLMRHSEDNPNQIRILAQTLTDGGVMDELINEELETFNSRWRELHEEAVRRQKLLEQSIQSAQETEKSLHLIQESLTFIDKQLAAYIADKVDAAQMPQEAQKIQSDLTSHEISLEEMKKHNQGKEAAQRVLSQIDVAQKKLQDVSMKFRLFQKPANFEQRLQESKMILDEVKMHLPALETKSVEQEVVQSQLNHCVNLYKSLSEVKSEVEMVIKTGRQIVQKKQTENPKELDERVTALKLHYNELGAKVTERKQQLEKCLKLSRKMRKEMNVLTEWLAATDMELTKRSAVEGMPSNLDSEVAWGKATQKEIEKQKVHLKSITEVGEALKTVLGKKETLVEDKLSLLNSNWIAVTSRAEEWLNLLLEYQKHMETFDQNVDHITKWIIQADTLLDESEKKKPQQKEDVLKRLKAELNDIRPKVDSTRDQAANLMANRGDHCRKLVEPQISELNHRFAAISHRIKTGKASIPLKELEQFNSDIQKLLEPLEAEIQQGVNLKEEDFNKDMNEDNEGTVKELLQRGDNLQQRITDERKREEIKIKQQLLQTKHNALKDLRSQRRKKALEISHQWYQYKRQADDLLKCLDDIEKKLASLPEPRDERKIKEIDRELQKKKEELNAVRRQAEGLSEDGAAMAVEPTQIQLSKRWREIESKFAQFRRLNFAQIHTVREETMMVMTEDMPLEISYVPSTYLTEITHVSQALLEVEQLLNAPDLCAKDFEDLFKQEESLKNIKDSLQQSSGRIDIIHSKKTAALQSATPVERVKLQEALSQLDFQWEKVNKMYKDRQGRFDRSVEKWRRFHYDIKIFNQWLTEAEQFLRKTQIPENWEHAKYKWYLKELQDGIGQRQTVVRTLNATGEEIIQQSSKTDASILQEKLGSLNLRWQEVCKQLSDRKKRLEEQKNILSEFQRDLNEFVLWLEEADNIASIPLEPGKEQQLKEKLEQVKLLVEELPLRQGILKQLNETGGPVLVSAPISPEEQDKLENKLKQTNLQWIKVSRALPEKQGEIEAQIKDLGQLEKKLEDLEEQLNHLLLWLSPIRNQLEIYNQPNQEGPFDVKETEIAVQAKQPDVEEILSKGQHLYKEKPATQPVKRKLEDLSSEWKAVNRLLQELRAKQPDLAPGLTTIGASPTQTVTLVTQPVVTKETAISKLEMPSSLMLEVPALADFNRAWTELTDWLSLLDQVIKSQRVMVGDLEDINEMIIKQKATMQDLEQRRPQLEELITAAQNLKNKTSNQEARTIITDRIERIQNQWDEVQEHLQNRRQQLNEMLKDSTQWLEAKEEAEQVLGQARAKLESWKEGPYTVDAIQKKITETKQLAKDLRQWQTNVDVANDLALKLLRDYSADDTRKVHMITENINASWRSIHKRVSEREAALEETHRLLQQFPLDLEKFLAWLTEAETTANVLQDATRKERLLEDSKGVKELMKQWQDLQGEIEAHTDVYHNLDENSQKILRSLEGSDDAVLLQRRLDNMNFKWSELRKKSLNIRSHLEASSDQWKRLHLSLQELLVWLQLKDDELSRQAPIGGDFPAVQKQNDVHRAFKRELKTKEPVIMSTLETVRIFLTEQPLEGLEKLYQEPRELPPEERAQNVTRLLRKQAEEVNTEWEKLNLHSADWQRKIDETLERLQELQEATDELDLKLRQAEVIKGSWQPVGDLLIDSLQDHLEKVKALRGEIAPLKENVSHVNDLARQLTTLGIQLSPYNLSTLEDLNTRWKLLQVAVEDRVRQLHEAHRDFGPASQHFLSTSVQGPWERAISPNKVPYYINHETQTTCWDHPKMTELYQSLADLNNVRFSAYRTAMKLRRLQKALCLDLLSLSAACDALDQHNLKQNDQPMDILQIINCLTTIYDRLEQEHNNLVNVPLCVDMCLNWLLNVYDTGRTGRIRVLSFKTGIISLCKAHLEDKYRYLFKQVASSTGFCDQRRLGLLLHDSIQIPRQLGEVASFGGSNIEPSVRSCFQFANNKPEIEAALFLDWMRLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIIGFRYRSLKHFNYDICQSCFFSGRVAKGHKMHYPMVEYCTPTTSGEDVRDFAKVLKNKFRTKRYFAKHPRMGYLPVQTVLEGDNMETPVTLINFWPVDSAPASSPQLSHDDTHSRIEHYASRLAEMENSNGSYLNDSISPNESIDDEHLLIQHYCQSLNQDSPLSQPRSPAQILISLESEERGELERILADLEEENRNLQAEYDRLKQQHEHKGLSPLPSPPEMMPTSPQSPRDAELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPQAEAKVNGTTVSSPSTSLQRSDSSQPMLLRVVGSQTSDSMGEEDLLSPPQDTSTGLEEVMEQLNNSFPSSRGRNTPGKPMREDTM DIP protein P11532 original sequence version: 199 24FF7E83F1E6BF8D arhg6_human Rho guanine nucleotide exchange factor 6 ARHGEF6 COOL2 KIAA0006 PIXA Rac/Cdc42 guanine nucleotide exchange factor 6 PAK-interacting exchange factor alpha Alpha-Pix COOL-2 protein protein human Homo sapiens Human MNPEEQIVTWLISLGVLESPKKTICDPEEFLKSSLKNGVVLCKLINRLMPGSVEKFCLDPQTEADCINNINDFLKGCATLQVEIFDPDDLYSGVNFSKVLSTLLAVNKATEDQLSERPCGRSSSLSAANTSQTNPQGAVSSTVSGLQRQSKTVEMTENGSHQLIVKARFNFKQTNEDELSVCKGDIIYVTRVEEGGWWEGTLNGRTGWFPSNYVREIKSSERPLSPKAVKGFETAPLTKNYYTVVLQNILDTEKEYAKELQSLLVTYLRPLQSNNNLSTVEVTSLLGNFEEVCTFQQTLCQALEECSKFPENQHKVGGCLLSLMPHFKSMYLAYCANHPSAVNVLTQHSDELEQFMENQGASSPGILILTTNLSKPFMRLEKYVTLLQELERHMEDTHPDHQDILKAIVAFKTLMGQCQDLRKRKQLELQILSEPIQAWEGEDIKNLGNVIFMSQVMVQYGACEEKEERYLMLFSNVLIMLSASPRMSGFIYQGKIPIAGTVVTRLDEIEGNDCTFEITGNTVERIVVHCNNNQDFQEWLEQLNRLIRGPASCSSLSKTSSSSCSAHSSFSSTGQPRGPLEPPQIIKPWSLSCLRPAPPLRPSAALGYKERMSYILKESSKSPKTMKKFLHKRKTERKPSEEEYVIRKSTAALEEDAQILKVIEAYCTSANFQQGHGSSTRKDSIPQVLLPEEEKLIIEETRSNGQTIMEEKSLVDTVYALKDEVRELKQENKRMKQCLEEELKSRRDLEKLVRRLLKQTDECIRGESSSKTSILP DIP protein Q15052 original sequence version: 165 5D2622314E46341B 5ht2a_human 5-hydroxytryptamine receptor 2A HTR2A HTR2 Serotonin receptor 2A protein protein human Homo sapiens Human MDILCEENTSLSSTTNSLMQLNDDTRLYSNDFNSGEANTSDAFNWTVDSENRTNLSCEGCLSPSCLSLLHLQEKNWSALLTAVVIILTIAGNILVIMAVSLEKKLQNATNYFLMSLAIADMLLGFLVMPVSMLTILYGYRWPLPSKLCAVWIYLDVLFSTASIMHLCAISLDRYVAIQNPIHHSRFNSRTKAFLKIIAVWTISVGISMPIPVFGLQDDSKVFKEGSCLLADDNFVLIGSFVSFFIPLTIMVITYFLTIKSLQKEATLCVSDLGTRAKLASFSFLPQSSLSSEKLFQRSIHREPGSYTGRRTMQSISNEQKACKVLGIVFFLFVVMWCPFFITNIMAVICKESCNEDVIGALLNVFVWIGYLSSAVNPLVYTLFNKTYRSAFSRYIQCQYKENKKPLQLILVNTIPALAYKSSQLQMGQKKNSKQDAKTTDNDCSMVALGKQHSEEASKDNSDGVNEKVSCV EF8AAC0BC5379DA2 faah1_human Fatty-acid amide hydrolase 1 Oleamide hydrolase 1 Anandamide amidohydrolase 1 FAAH FAAH1 Fatty acid ester hydrolase protein protein human Homo sapiens Human MVQYELWAALPGASGVALACCFVAAAVALRWSGRRTARGAVVRARQRQRAGLENMDRAAQRFRLQNPDLDSEALLALPLPQLVQKLHSRELAPEAVLFTYVGKAWEVNKGTNCVTSYLADCETQLSQAPRQGLLYGVPVSLKECFTYKGQDSTLGLSLNEGVPAECDSVVVHVLKLQGAVPFVHTNVPQSMFSYDCSNPLFGQTVNPWKSSKSPGGSSGGEGALIGSGGSPLGLGTDIGGSIRFPSSFCGICGLKPTGNRLSKSGLKGCVYGQEAVRLSVGPMARDVESLALCLRALLCEDMFRLDPTVPPLPFREEVYTSSQPLRVGYYETDNYTMPSPAMRRAVLETKQSLEAAGHTLVPFLPSNIPHALETLSTGGLFSDGGHTFLQNFKGDFVDPCLGDLVSILKLPQWLKGLLAFLVKPLLPRLSAFLSNMKSRSAGKLWELQHEIEVYRKTVIAQWRALDLDVVLTPMLAPALDLNAPGRATGAVSYTMLYNCLDFPAGVVPVTTVTAEDEAQMEHYRGYFGDIWDKMLQKGMKKSVGLPVAVQCVALPWQEELCLRFMREVERLMTPEKQSS 633A92DC36940C18 cltr2_human Cysteinyl leukotriene receptor 2 CYSLTR2 CYSLT2 CYSLT2R G-protein coupled receptor GPCR21 G-protein coupled receptor HG57 HPN321 PSEC0146 protein protein human Homo sapiens Human MERKFMSLQPSISVSEMEPNGTFSNNNSRNCTIENFKREFFPIVYLIIFFWGVLGNGLSIYVFLQPYKKSTSVNVFMLNLAISDLLFISTLPFRADYYLRGSNWIFGDLACRIMSYSLYVNMYSSIYFLTVLSVVRFLAMVHPFRLLHVTSIRSAWILCGIIWILIMASSIMLLDSGSEQNGSVTSCLELNLYKIAKLQTMNYIALVVGCLLPFFTLSICYLLIIRVLLKVEVPESGLRVSHRKALTTIIITLIIFFLCFLPYHTLRTVHLTTWKVGLCKDRLHKALVITLALAAANACFNPLLYYFAGENFKDRLKSALRKGHPQKAKTKCVFPVSVWLRKETRV sntb1_human Beta-1-syntrophin SNTB1 SNT2B1 59 kDa dystrophin-associated protein A1 basic component 1 Tax interaction protein 43 Syntrophin-2 BSYN2 protein protein human Homo sapiens Human MAVAAAAAAAGPAGAGGGRAQRSGLLEVLVRDRWHKVLVNLSEDALVLSSEEGAAAYNGIGTATNGSFCRGAGAGHPGAGGAQPPDSPAGVRTAFTDLPEQVPESISNQKRGVKVLKQELGGLGISIKGGKENKMPILISKIFKGLAADQTQALYVGDAILSVNGADLRDATHDEAVQALKRAGKEVLLEVKYMREATPYVKKGSPVSEIGWETPPPESPRLGGSTSDPPSSQSFSFHRDRKSIPLKMCYVTRSMALADPENRQLEIHSPDAKHTVILRSKDSATAQAWFSAIHSNVNDLLTRVIAEVREQLGKTGIAGSREIRHLGWLAEKVPGESKKQWKPALVVLTEKDLLIYDSMPRRKEAWFSPVHTYPLLATRLVHSGPGKGSPQAGVDLSFATRTGTRQGIETHLFRAETSRDLSHWTRSIVQGCHNSAELIAEISTACTYKNQECRLTIHYENGFSITTEPQEGAFPKTIIQSPYEKLKMSSDDGIRMLYLDFGGKDGEIQLDLHSCPKPIVFIIHSFLSAKITRLGLVA BF8E7B416D5CF289 cxcr5_human C-X-C chemokine receptor type 5 CXCR5 BLR1 MDR15 Burkitt lymphoma receptor 1 Monocyte-derived receptor 15 protein protein human Homo sapiens Human MNYPLTLEMDLENLEDLFWELDRLDNYNDTSLVENHLCPATEGPLMASFKAVFVPVAYSLIFLLGVIGNVLVLVILERHRQTRSSTETFLFHLAVADLLLVFILPFAVAEGSVGWVLGTFLCKTVIALHKVNFYCSSLLLACIAVDRYLAIVHAVHAYRHRRLLSIHITCGTIWLVGFLLALPEILFAKVSQGHHNNSLPRCTFSQENQAETHAWFTSRFLYHVAGFLLPMLVMGWCYVGVVHRLRQAQRRPQRQKAVRVAILVTSIFFLCWSPYHIVIFLDTLARLKAVDNTCKLNGSLPVAITMCEFLGLAHCCLNPMLYTFAGVKFRSDLSRLLTKLGCTGPASLCQLFPSWRRSSLSESENATSLTTF 6DF84C839492ACCF golp3_human Golgi phosphoprotein 3 GOLPH3 GPP34 Coat protein GPP34 Mitochondrial DNA absence factor protein protein human Homo sapiens Human MTSLTQRSSGLVQRRTEASRNAADKERAAGGGAGSSEDDAQSRRDEQDDDDKGDSKETRLTLMEEVLLLGLKDREGYTSFWNDCISSGLRGCMLIELALRGRLQLEACGMRRKSLLTRKVICKSDAPTGDVLLDEALKHVKETQPPETVQNWIELLSGETWNPLKLHYQLRNVRERLAKNLVEKGVLTTEKQNFLLFDMTTHPLTNNNIKQRLIKKVQEAVLDKWVNDPHRMDRRLLALIYLAHASDVLENAFAPLLDEQYDLATKRVRQLLDLDPEVECLKANTNEVLWAVVAAFTK 34FAD78155CC214A mk01_human Mitogen-activated protein kinase 1 MAPK1 ERK2 PRKM1 Extracellular signal-regulated kinase 2 Mitogen-activated protein kinase 2 MAP kinase isoform p42 ERT1 PRKM2 protein protein human Homo sapiens Human MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS DIP protein P28482 original sequence version: 173 DIP protein P28482 original sequence version: 103 DIP protein P28482 original sequence version: 101 DIP protein P28482 original sequence version: 131 DIP protein P28482 original sequence version: 156 DIP protein P28482 original sequence version: 166 DIP protein P28482 original sequence version: 144 E85D0B2A5D2D724E csk21_human Casein kinase II subunit alpha CSNK2A1 CK2A1 protein protein human Homo sapiens Human MSGPVPSRARVYTDVNTHRPREYWDYESHVVEWGNQDDYQLVRKLGRGKYSEVFEAINITNNEKVVVKILKPVKKKKIKREIKILENLRGGPNIITLADIVKDPVSRTPALVFEHVNNTDFKQLYQTLTDYDIRFYMYEILKALDYCHSMGIMHRDVKPHNVMIDHEHRKLRLIDWGLAEFYHPGQEYNVRVASRYFKGPELLVDYQMYDYSLDMWSLGCMLASMIFRKEPFFHGHDNYDQLVRIAKVLGTEDLYDYIDKYNIELDPRFNDILGRHSRKRWERFVHSENQHLVSPEALDFLDKLLRYDHQSRLTAREAMEHPYFYTVVKDQARMGSSSMPGGSTPVSSANMMSGISSVPTPSPLGPLAGSPVIAAANPLGMPVPAAAGAQQ DIP protein P68400 original sequence version: 88 DIP protein P68400 original sequence version: 78 DIP protein P68400 original sequence version: 100 DIP protein P68400 original sequence version: 110 DIP protein P68400 original sequence version: 125 DIP protein P68400 original sequence version: 136 D3B6F5D13FF7422D lipa1_human Liprin-alpha-1 Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1 LAR-interacting protein 1 PPFIA1 LIP1 protein protein human Homo sapiens Human MMCEVMPTISEAEGPPGGGGGHGSGSPSQPDADSHFEQLMVSMLEERDRLLDTLRETQETLALTQGKLHEVGHERDSLQRQLNTALPQEFAALTKELNVCREQLLEREEEIAELKAERNNTRLLLEHLECLVSRHERSLRMTVVKRQAQSPAGVSSEVEVLKALKSLFEHHKALDEKVRERLRVALERCSLLEEELGATHKELMILKEQNNQKKTLTDGVLDINHEQENTPSTSGKRSSDGSLSHEEDLAKVIELQEIISKQSREQSQMKERLASLSSHVTELEEDLDTARKDLIKSEEMNTKLQRDVREAMAQKEDMEERITTLEKRYLAAQREATSVHDLNDKLENEIANKDSMHRQTEDKNRQLQERLELAEQKLQQTLRKAETLPEVEAELAQRVAALSKAEERHGNIEERLRQMEAQLEEKNQELQRARQREKMNEEHNKRLSDTVDKLLSESNERLQLHLKERMAALEDKNSLLREVESAKKQLEETQHDKDQLVLNIEALRAELDHMRLRGASLHHGRPHLGSVPDFRFPMADGHTDSYSTSAVLRRPQKGRLAALRDEPSKVQTLNEQDWERAQQASVLANVAQAFESDADVSDGEDDRDTLLSSVDLLSPSGQADAHTLAMMLQEQLDAINKEIRLIQEEKENTEQRAEEIESRVGSGSLDNLGRFRSMSSIPPYPASSLASSSPPGSGRSTPRRIPHSPAREVDRLGVMTLLPPSREEVRDDKTTIKCETSPPSSPRALRLDRLHKGALHTVSHEDIRDIRNSTGSQDGPVSNPSSSNSSQDSLHKAPKKKGIKSSIGRLFGKKEKGRPGQTGKEALGQAGVSETDNSSQDALGLSKLGGQAEKNRKLQKKHELLEEARRQGLPFAQWDGPTVVVWLELWVGMPAWYVAACRANVKSGAIMSALSDTEIQREIGISNPLHRLKLRLAIQEIMSLTSPSAPPTSRTTLAYGDMNHEWIGNEWLPSLGLPQYRSYFMECLVDARMLDHLTKKDLRGQLKMVDSFHRNSFQCGIMCLRRLNYDRKELERKREESQSEIKDVLVWSNDRVIRWILSIGLKEYANNLIESGVHGALLALDETFDFSALALLLQIPTQNTQARAVLEREFNNLLVMGTDRRFDEDDDKSFRRAPSWRKKFRPKDIRGLAAGSAETLPANFRVTSSMSSPSMQPKKMQMDGNVSGTQRLDSATVRTYSC C8CF7C20B298BFB1 1433e_human 14-3-3 protein epsilon YWHAE protein protein human Homo sapiens Human MDDREDLVYQAKLAEQAERYDEMVESMKKVAGMDVELTVEERNLLSVAYKNVIGARRASWRIISSIEQKEENKGGEDKLKMIREYRQMVETELKLICCDILDVLDKHLIPAANTGESKVFYYKMKGDYHRYLAEFATGNDRKEAAENSLVAYKAASDIAMTELPPTHPIRLGLALNFSVFYYEILNSPDRACRLAKAAFDDAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDMQGDGEEQNKEALQDVEDENQ DIP protein P62258 original sequence version: 130 DIP protein P62258 original sequence version: 132 DIP protein P62258 original sequence version: 91 07817CCBD1F75B26 pp6r1_human Serine/threonine-protein phosphatase 6 regulatory subunit 1 PPP6R1 KIAA1115 PP6R1 SAPS domain family member 1 SAPS1 protein protein human Homo sapiens Human MFWKFDLHTSSHLDTLLEREDLSLPELLDEEDVLQECKVVNRKLLDFLLQPPHLQAMVAWVTQEPPDSGEERLRYKYPSVACEILTSDVPQINDALGADESLLNRLYGFLQSTGSLNPLLASFFSKVMGILINRKTDQLVSFLRKKDDFVDLLLQHIGTSAIMDLLLRLLTCVERPQLRQDVVNWLNEEKIVQRLIEQIHPSKDENQHSNASQSLCDIIRLSREQMIQVQDSPEPDQLLATLEKQETIEQLLSNMFEGEQSQSVIVSGIQVLLTLLEPRRPRSESVTVNSFFSSVDGQLELLAQGALESTVSSVGALHALRPRLSCFHQLLLEPPKLEPLQMTWGMLAPPLGNTRLHVVKLLASALSANDAALTHELLALDVPNTMLDLFFHYVFNNFLHAQVEGCVSTMLSLGPPPDSSPETPIQNPVVKHLLQQCRLVERILTSWEENDRVQCAGGPRKGYMGHLTRVAGALVQNTEKGPNAEQLRQLLKELPSEQQEQWEAFVSGPLAETNKKNMVDLVNTHHLHSSSDDEDDRLKEFNFPEEAVLQQAFMDFQMQRMTSAFIDHFGFNDEEFGEQEESVNAPFDKTANITFSLNADDENPNANLLEICYKDRIQQFDDDEEEEDEEEAQGSGESDGEDGAWQGSQLARGARLGQPPGVRSGGSTDSEDEEEEDEEEEEDEEGIGCAARGGATPLSYPSPGPQPPGPSWTATFDPVPTDAPTSPRVSGEEELHTGPPAPQGPLSVPQGLPTQSLASPPARDALQLRSQDPTPPSAPQEATEGSKVTEPSAPCQALVSIGDLQATFHGIRSAPSSSDSATRDPSTSVPASGAHQPPQTTEGEKSPEPLGLPQSQSAQALTPPPIPNGSAPEGPASPGSQ 36DDA2E945ED599A cxcr3_human C-X-C chemokine receptor type 3 CXCR3 CKR-L2 G protein-coupled receptor 9 GPR9 Interferon-inducible protein 10 receptor protein protein human Homo sapiens Human MVLEVSDHQVLNDAEVAALLENFSSSYDYGENESDSCCTSPPCPQDFSLNFDRAFLPALYSLLFLLGLLGNGAVAAVLLSRRTALSSTDTFLLHLAVADTLLVLTLPLWAVDAAVQWVFGSGLCKVAGALFNINFYAGALLLACISFDRYLNIVHATQLYRRGPPARVTLTCLAVWGLCLLFALPDFIFLSAHHDERLNATHCQYNFPQVGRTALRVLQLVAGFLLPLLVMAYCYAHILAVLLVSRGQRRLRAMRLVVVVVVAFALCWTPYHLVVLVDILMDLGALARNCGRESRVDVAKSVTSGLGYMHCCLNPLLYAFVGVKFRERMWMLLLRLGCPNQRGLQRQPSSSRRDSSWSETSEASYSGL F08A3B44B2BBAD04 ghdc_human GH3 domain-containing protein GHDC D11LGP1E LGP1 protein protein human Homo sapiens Human MLLWPLLLLLLLLPTLALLRQQRSQDARLSWLAGLQHRVAWGALVWAATWQRRRLEQSTLHVHQSQQQALRWCLQGAQRPHCSLRRSTDISTFRNHLPLTKASQTQQEDSGEQPLPPTSNQDLGEASLQATLLGLAALNKAYPEVLAQGRTARVTLTSPWPRPLPWPGNTLGQVGTPGTKDPRALLLDALRSPGLRALEAGTAVELLDVFLGLETDGEELAGAIAAGNPGAPLRERAAELREALEQGPRGLALRLWPKLQVVVTLDAGGQAEAVAALGALWCQGLAFFSPAYAASGGVLGLNLQPEQPHGLYLLPPGAPFIELLPVKEGTQEEAASTLLLAEAQQGKEYELVLTDRASLTRCRLGDVVRVVGAYNQCPVVRFICRLDQTLSVRGEDIGEDLFSEALGRAVGQWAGAKLLDHGCVESSILDSSAGSAPHYEVFVALRGLRNLSEENRDKLDHCLQEASPRYKSLRFWGSVGPARVHLVGQGAFRALRAALAACPSSPFPPAMPRVLRHRHLAQCLQERVVS BC0D92AC78889C16 mpp7_human MAGUK p55 subfamily member 7 MPP7 protein protein human Homo sapiens Human MPALSTGSGSDTGLYELLAALPAQLQPHVDSQEDLTFLWDMFGEKSLHSLVKIHEKLHYYEKQSPVPILHGAAALADDLAEELQNKPLNSEIRELLKLLSKPNVKALLSVHDTVAQKNYDPVLPPMPEDIDDEEDSVKIIRLVKNREPLGATIKKDEQTGAIIVARIMRGGAADRSGLIHVGDELREVNGIPVEDKRPEEIIQILAQSQGAITFKIIPGSKEETPSKEGKMFIKALFDYNPNEDKAIPCKEAGLSFKKGDILQIMSQDDATWWQAKHEADANPRAGLIPSKHFQERRLALRRPEILVQPLKVSNRKSSGFRKSFRLSRKDKKTNKSMYECKKSDQYDTADVPTYEEVTPYRRQTNEKYRLVVLVGPVGVGLNELKRKLLISDTQHYGVTVPHTTRARRSQESDGVEYIFISKHLFETDVQNNKFIEYGEYKNNYYGTSIDSVRSVLAKNKVCLLDVQPHTVKHLRTLEFKPYVIFIKPPSIERLRETRKNAKIISSRDDQGAAKPFTEEDFQEMIKSAQIMESQYGHLFDKIIINDDLTVAFNELKTTFDKLETETHWVPVSWLHS 86366E460A08C6A7 ssr1_human Somatostatin receptor type 1 SRIF-2 SSTR1 protein protein human Homo sapiens Human MFPNGTASSPSSSPSPSPGSCGEGGGSRGPGAGAADGMEEPGRNASQNGTLSEGQGSAILISFIYSVVCLVGLCGNSMVIYVILRYAKMKTATNIYILNLAIADELLMLSVPFLVTSTLLRHWPFGALLCRLVLSVDAVNMFTSIYCLTVLSVDRYVAVVHPIKAARYRRPTVAKVVNLGVWVLSLLVILPIVVFSRTAANSDGTVACNMLMPEPAQRWLVGFVLYTFLMGFLLPVGAICLCYVLIIAKMRMVALKAGWQQRKRSERKITLMVMMVVMVFVICWMPFYVVQLVNVFAEQDDATVSQLSVILGYANSCANPILYGFLSDNFKRSFQRILCLSWMDNAAEEPVDYYATALKSRAYSVEDFQPENLESGGVFRNGTCTSRITTL 85C99AFFF339A43D lipb1_human Liprin-beta-1 Protein tyrosine phosphatase receptor type f polypeptide-interacting protein-binding protein 1 PPFIBP1 KIAA1230 hSGT2 protein protein human Homo sapiens Human MMSDASDMLAAALEQMDGIIAGSKALEYSNGIFDCQSPTSPFMGSLRALHLVEDLRGLLEMMETDEKEGLRCQIPDSTAETLVEWLQSQMTNGHLPGNGDVYQERLARLENDKESLVLQVSVLTDQVEAQGEKIRDLEFCLEEHREKVNATEEMLQQELLSRTSLETQKLDLMAEISNLKLKLTAVEKDRLDYEDKFRDTEGLIQEINDLRLKVSEMDSERLQYEKKLKSTKSLMAKLSSMKIKVGQMQYEKQRMEQKWESLKDELASLKEQLEEKESEVKRLQEKLVCKMKGEGVEIVDRDIEVQKMKKAVESLMAANEEKDRKIEDLRQCLNRYKKMQDTVVLAQGKDGEYEELLNSSSISSLLDAQGFSDLEKSPSPTPVMGSPSCDPFNTSVPEEFHTTILQVSIPSLLPATVSMETSEKSKLTPKPETSFEENDGNIILGATVDTQLCDKLLTSSLQKSSSLGNLKKETSDGEKETIQKTSEDRAPAESRPFGTLPPRPPGQDTSMDDNPFGTRKVRSSFGRGFFKIKSNKRTASAPNLAETEKETAEHLDLAGASSRPKDSQRNSPFQIPPPSPDSKKKSRGIMKLFGKLRRSQSTTFNPDDMSEPEFKRGGTRATAGPRLGWSRDLGQSNSDLDMPFAKWTKEQVCNWLMEQGLGSYLNSGKHWIASGQTLLQASQQDLEKELGIKHSLHRKKLQLALQALGSEEETNHGKLDFNWVTRWLDDIGLPQYKTQFDEGRVDGRMLHYMTVDDLLSLKVVSVLHHLSIKRAIQVLRINNFEPNCLRRRPSDENTIAPSEVQKWTNHRVMEWLRSVDLAEYAPNLRGSGVHGGLMVLEPRFNVETMAQLLNIPPNKTLLRRHLATHFNLLIGAEAQHQKRDAMELPDYVLLTATAKVKPKKLAFSNFGNLRKKKQEDGEEYVCPMELGQASGSASKKGFKPGLDMRLYEEDDLDRLEQMEDSEGTVRQIGAFSEGINNLTHMLKEDDMFKDFAARSPSASITDEDSNV 20E30DD99ACD5A92 utrn_human Utrophin UTRN DMDL Dystrophin-related protein 1 DRP1 protein protein human Homo sapiens Human MAKYGEHEASPDNGQNEFSDIIKSRSDEHNDVQKKTFTKWINARFSKSGKPPINDMFTDLKDGRKLLDLLEGLTGTSLPKERGSTRVHALNNVNRVLQVLHQNNVELVNIGGTDIVDGNHKLTLGLLWSIILHWQVKDVMKDVMSDLQQTNSEKILLSWVRQTTRPYSQVNVLNFTTSWTDGLAFNAVLHRHKPDLFSWDKVVKMSPIERLEHAFSKAQTYLGIEKLLDPEDVAVQLPDKKSIIMYLTSLFEVLPQQVTIDAIREVETLPRKYKKECEEEAINIQSTAPEEEHESPRAETPSTVTEVDMDLDSYQIALEEVLTWLLSAEDTFQEQDDISDDVEEVKDQFATHEAFMMELTAHQSSVGSVLQAGNQLITQGTLSDEEEFEIQEQMTLLNARWEALRVESMDRQSRLHDVLMELQKKQLQQLSAWLTLTEERIQKMETCPLDDDVKSLQKLLEEHKSLQSDLEAEQVKVNSLTHMVVIVDENSGESATAILEDQLQKLGERWTAVCRWTEERWNRLQEINILWQELLEEQCLLKAWLTEKEEALNKVQTSNFKDQKELSVSVRRLAILKEDMEMKRQTLDQLSEIGQDVGQLLDNSKASKKINSDSEELTQRWDSLVQRLEDSSNQVTQAVAKLGMSQIPQKDLLETVRVREQAITKKSKQELPPPPPPKKRQIHVDIEAKKKFDAISAELLNWILKWKTAIQTTEIKEYMKMQDTSEMKKKLKALEKEQRERIPRADELNQTGQILVEQMGKEGLPTEEIKNVLEKVSSEWKNVSQHLEDLERKIQLQEDINAYFKQLDELEKVIKTKEEWVKHTSISESSRQSLPSLKDSCQRELTNLLGLHPKIEMARASCSALMSQPSAPDFVQRGFDSFLGRYQAVQEAVEDRQQHLENELKGQPGHAYLETLKTLKDVLNDSENKAQVSLNVLNDLAKVEKALQEKKTLDEILENQKPALHKLAEETKALEKNVHPDVEKLYKQEFDDVQGKWNKLKVLVSKDLHLLEEIALTLRAFEADSTVIEKWMDGVKDFLMKQQAAQGDDAGLQRQLDQCSAFVNEIETIESSLKNMKEIETNLRSGPVAGIKTWVQTRLGDYQTQLEKLSKEIATQKSRLSESQEKAANLKKDLAEMQEWMTQAEEEYLERDFEYKSPEELESAVEEMKRAKEDVLQKEVRVKILKDNIKLLAAKVPSGGQELTSELNVVLENYQLLCNRIRGKCHTLEEVWSCWIELLHYLDLETTWLNTLEERMKSTEVLPEKTDAVNEALESLESVLRHPADNRTQIRELGQTLIDGGILDDIISEKLEAFNSRYEDLSHLAESKQISLEKQLQVLRETDQMLQVLQESLGELDKQLTTYLTDRIDAFQVPQEAQKIQAEISAHELTLEELRRNMRSQPLTSPESRTARGGSQMDVLQRKLREVSTKFQLFQKPANFEQRMLDCKRVLDGVKAELHVLDVKDVDPDVIQTHLDKCMKLYKTLSEVKLEVETVIKTGRHIVQKQQTDNPKGMDEQLTSLKVLYNDLGAQVTEGKQDLERASQLARKMKKEAASLSEWLSATETELVQKSTSEGLLGDLDTEISWAKNVLKDLEKRKADLNTITESSAALQNLIEGSEPILEERLCVLNAGWSRVRTWTEDWCNTLMNHQNQLEIFDGNVAHISTWLYQAEALLDEIEKKPTSKQEEIVKRLVSELDDANLQVENVRDQALILMNARGSSSRELVEPKLAELNRNFEKVSQHIKSAKLLIAQEPLYQCLVTTETFETGVPFSDLEKLENDIENMLKFVEKHLESSDEDEKMDEESAQIEEVLQRGEEMLHQPMEDNKKEKIRLQLLLLHTRYNKIKAIPIQQRKMGQLASGIRSSLLPTDYLVEINKILLCMDDVELSLNVPELNTAIYEDFSFQEDSLKNIKDQLDKLGEQIAVIHEKQPDVILEASGPEAIQIRDTLTQLNAKWDRINRMYSDRKGCFDRAMEEWRQFHCDLNDLTQWITEAEELLVDTCAPGGSLDLEKARIHQQELEVGISSHQPSFAALNRTGDGIVQKLSQADGSFLKEKLAGLNQRWDAIVAEVKDRQPRLKGESKQVMKYRHQLDEIICWLTKAEHAMQKRSTTELGENLQELRDLTQEMEVHAEKLKWLNRTELEMLSDKSLSLPERDKISESLRTVNMTWNKICREVPTTLKECIQEPSSVSQTRIAAHPNVQKVVLVSSASDIPVQSHRTSEISIPADLDKTITELADWLVLIDQMLKSNIVTVGDVEEINKTVSRMKITKADLEQRHPQLDYVFTLAQNLKNKASSSDMRTAITEKLERVKNQWDGTQHGVELRQQQLEDMIIDSLQWDDHREETEELMRKYEARLYILQQARRDPLTKQISDNQILLQELGPGDGIVMAFDNVLQKLLEEYGSDDTRNVKETTEYLKTSWINLKQSIADRQNALEAEWRTVQASRRDLENFLKWIQEAETTVNVLVDASHRENALQDSILARELKQQMQDIQAEIDAHNDIFKSIDGNRQKMVKALGNSEEATMLQHRLDDMNQRWNDLKAKSASIRAHLEASAEKWNRLLMSLEELIKWLNMKDEELKKQMPIGGDVPALQLQYDHCKALRRELKEKEYSVLNAVDQARVFLADQPIEAPEEPRRNLQSKTELTPEERAQKIAKAMRKQSSEVKEKWESLNAVTSNWQKQVDKALEKLRDLQGAMDDLDADMKEAESVRNGWKPVGDLLIDSLQDHIEKIMAFREEIAPINFKVKTVNDLSSQLSPLDLHPSLKMSRQLDDLNMRWKLLQVSVDDRLKQLQEAHRDFGPSSQHFLSTSVQLPWQRSISHNKVPYYINHQTQTTCWDHPKMTELFQSLADLNNVRFSAYRTAIKIRRLQKALCLDLLELSTTNEIFKQHKLNQNDQLLSVPDVINCLTTTYDGLEQMHKDLVNVPLCVDMCLNWLLNVYDTGRTGKIRVQSLKIGLMSLSKGLLEEKYRYLFKEVAGPTEMCDQRQLGLLLHDAIQIPRQLGEVAAFGGSNIEPSVRSCFQQNNNKPEISVKEFIDWMHLEPQSMVWLPVLHRVAAAETAKHQAKCNICKECPIVGFRYRSLKHFNYDVCQSCFFSGRTAKGHKLHYPMVEYCIPTTSGEDVRDFTKVLKNKFRSKKYFAKHPRLGYLPVQTVLEGDNLETPITLISMWPEHYDPSQSPQLFHDDTHSRIEQYATRLAQMERTNGSFLTDSSSTTGSVEDEHALIQQYCQTLGGESPVSQPQSPAQILKSVEREERGELERIIADLEEEQRNLQVEYEQLKDQHLRRGLPVGSPPESIISPHHTSEDSELIAEAKLLRQHKGRLEARMQILEDHNKQLESQLHRLRQLLEQPESDSRINGVSPWASPQHSALSYSLDPDASGPQFHQAAGEDLLAPPHDTSTDLTEVMEQIHSTFPSCCPNVPSRPQAM DIP protein P46939 original sequence version: 90 DIP protein P46939 original sequence version: 162 DIP protein P46939 original sequence version: 121 C72CADE8CD666993 dtna_human Dystrobrevin alpha Alpha-dystrobrevin Dystrophin-related protein 3 DTNA DRP3 protein protein human Homo sapiens Human MIEDSGKRGNTMAERRQLFAEMRAQDLDRIRLSTYRTACKLRFVQKKCNLHLVDIWNVIEALRENALNNLDPNTELNVSRLEAVLSTIFYQLNKRMPTTHQIHVEQSISLLLNFLLAAFDPEGHGKISVFAVKMALATLCGGKIMDKLRYIFSMISDSSGVMVYGRYDQFLREVLKLPTAVFEGPSFGYTEQSARSCFSQQKKVTLNGFLDTLMSDPPPQCLVWLPLLHRLANVENVFHPVECSYCHSESMMGFRYRCQQCHNYQLCQDCFWRGHAGGSHSNQHQMKEYTSWKSPAKKLTNALSKSLSCASSREPLHPMFPDQPEKPLNLAHIVDTWPPRPVTSMNDTLFSHSVPSSGSPFITRSSPPKDSEVEQNKLLARAAPAFLKGKGIQYSLNVADRLADEHVLIGLYVNMLRNNPSCMLESSNRLDEEHRLIARYAARLAAESSSSQPPQQRSAPDISFTIDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEGLMKLLKTQGAGSPRSSPSHTISRPIPMPIRSASACSTPTHTPQDSLTGVGGDVQEAFAQSSRRNLRNDLLVAADSITNTMSSLVKELNSEVGSETESNVDSEFARTQFEDLVPSPTSEKAFLAQIHARKPGYIHSGATTSTMRGDMVTEDADPYVQPEDENYENDSVRQLENELQMEEYLKQKLQDEAYQVSLQG CFD77DAA57D050EC ctnl1_human Alpha-catulin Catenin alpha-like protein 1 Alpha-catenin-related protein CTNNAL1 protein protein human Homo sapiens Human MAASPGPAGVGGAGAVYGSGSSGFALDSGLEIKTRSVEQTLLPLVSQITTLINHKDNTKKSDKTLQAIQRVGQAVNLAVGRFVKVGEAIANENWDLKEEINIACIEAKQAGETIAALTDITNLNHLESDGQITIFTDKTGVIKAARLLLSSVTKVLLLADRVVIKQIITSRNKVLATMERLEKVNSFQEFVQIFSQFGNEMVEFAHLSGDRQNDLKDEKKKAKMAAARAVLEKCTMMLLTASKTCLRHPNCESAHKNKEGVFDRMKVALDKVIEIVTDCKPNGETDISSISIFTGIKEFKMNIEALRENLYFQSKENLSVTLEVILERMEDFTDSAYTSHEHRERILELSTQARMELQQLISVWIQAQSKKTKSIAEELELSILKISHSLNELKKELHSTATQLAADLLKYHADHVVLKALKLTGVEGNLEALAEYACKLSEQKEQLVETCRLLRHISGTEPLEITCIHAEETFQVTGQQIISAAETLTLHPSSKIAKENLDVFCEAWESQISDMSTLLREINDVFEGRRGEKYGYLSLPKPMKNNANLKSLKPDKPDSEEQAKIAKLGLKLGLLTSDADCEIEKWEDQENEIVQYGRNMSSMAYSLYLFTRGEGPLKTSQDLIHQLEVFAAEGLKLTSSVQAFSKQLKDDDKLMLLLEINKLIPLCHQLQTVTKTSLQNKVFLKVDKCITKTRSMMALLVQLLSLCYKLLKKLQMENNGWVSVTNKDTMDSKT DIP protein Q9UBT7 original sequence version: 121 8756237C73AAEA31 gopc_human Golgi-associated PDZ and coiled-coil motif-containing protein CAL FIG GOPC PDZ protein interacting specifically with TC10 CFTR-associated ligand Fused in glioblastoma protein protein human Homo sapiens Human MSAGGPCPAAAGGGPGGASCSVGAPGGVSMFRWLEVLEKEFDKAFVDVDLLLGEIDPDQADITYEGRQKMTSLSSCFAQLCHKAQSVSQINHKLEAQLVDLKSELTETQAEKVVLEKEVHDQLLQLHSIQLQLHAKTGQSADSGTIKAKLSGPSVEELERELEANKKEKMKEAQLEAEVKLLRKENEALRRHIAVLQAEVYGARLAAKYLDKELAGRVQQIQLLGRDMKGPAHDKLWNQLEAEIHLHRHKTVIRACRGRNDLKRPMQAPPGHDQDSLKKSQGVGPIRKVLLLKEDHEGLGISITGGKEHGVPILISEIHPGQPADRCGGLHVGDAILAVNGVNLRDTKHKEAVTILSQQRGEIEFEVVYVAPEVDSDDENVEYEDESGHRYRLYLDELEGGGNPGASCKDTSGEIKVLQGFNKKAVTDTHENGDLGTASETPLDDGASKLDDLHTLYHKKSY 8A19DDC376DCD0F4 1433f_human 14-3-3 protein eta YWHAH YWHA1 Protein AS1 protein protein human Homo sapiens Human MGDREQLLQRARLAEQAERYDDMASAMKAVTELNEPLSNEDRNLLSVAYKNVVGARRSSWRVISSIEQKTMADGNEKKLEKVKAYREKIEKELETVCNDVLSLLDKFLIKNCNDFQYESKVFYLKMKGDYYRYLAEVASGEKKNSVVEASEAAYKEAFEISKEQMQPTHPIRLGLALNFSVFYYEIQNAPEQACLLAKQAFDDAIAELDTLNEDSYKDSTLIMQLLRDNLTLWTSDQQDEEAGEGN DIP protein Q04917 original sequence version: 166 DIP protein Q04917 original sequence version: 168 DIP protein Q04917 original sequence version: 175 D70FBC100C45D6E5 git1_human ARF GTPase-activating protein GIT1 GIT1 G protein-coupled receptor kinase-interactor 1 GRK-interacting protein 1 Cool-associated and tyrosine-phosphorylated protein 1 p95-APP1 protein protein human Homo sapiens Human MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRHISIVKHLRHSAWPPTLLQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPIKSEFIRAKYQMLAFVHKLPCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQANFFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAERLVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADSLDLSELAKAAKKKLQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATRNQGRQKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSLRSQSDLDDQHDYDSVASDEDTDQEPLRSTGATRSNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQQLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPTPPLPSERAEHTPMAPGGSTHRRDRQAFSMYEPGSALKPFGGPPGDELTTRLQPFHSTELEDDAIYSVHVPAGLYRIRKGVSASAVPFTPSSPLLSCSQEGSRHTSKLSRHGSGADSDYENTQSGDPLLGLEGKRFLELGKEEDFHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVPCSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQLLTQQVIQCAYDIAKAAKQLVTITTREKKQ 702744942A796399 mk03_human Mitogen-activated protein kinase 3 ERT2 MAP kinase isoform p44 Microtubule-associated protein 2 kinase Extracellular signal-regulated kinase 1 Insulin-stimulated MAP2 kinase p44-ERK1 MAPK3 ERK1 PRKM3 protein protein human Homo sapiens Human MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP DIP protein P27361 original sequence version: 171 DIP protein P27361 original sequence version: 101 DIP protein P27361 original sequence version: 124 DIP protein P27361 original sequence version: 129 DIP protein P27361 original sequence version: 143 E6020CE413EC41F7 5ht2b_human 5-hydroxytryptamine receptor 2B HTR2B Serotonin receptor 2B protein protein human Homo sapiens Human MALSYRVSELQSTIPEHILQSTFVHVISSNWSGLQTESIPEEMKQIVEEQGNKLHWAALLILMVIIPTIGGNTLVILAVSLEKKLQYATNYFLMSLAVADLLVGLFVMPIALLTIMFEAMWPLPLVLCPAWLFLDVLFSTASIMHLCAISVDRYIAIKKPIQANQYNSRATAFIKITVVWLISIGIAIPVPIKGIETDVDNPNNITCVLTKERFGDFMLFGSLAAFFTPLAIMIVTYFLTIHALQKKAYLVKNKPPQRLTWLTVSTVFQRDETPCSSPEKVAMLDGSRKDKALPNSGDETLMRRTSTIGKKSVQTISNEQRASKVLGIVFFLFLLMWCPFFITNITLVLCDSCNQTTLQMLLEIFVWIGYVSSGVNPLVYTLFNKTFRDAFGRYITCNYRATKSVKTLRKRSSKIYFRNPMAENSKFFKKHGIRNGINPAMYQSPMRLRSSTIQSSSIILLDTLLLTENEGDKTEEQVSYV mint This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system CDA4447ECDBA3B46 ada1d_human Alpha-1D adrenergic receptor Alpha-1D adrenoreceptor Alpha-1A adrenergic receptor Alpha-adrenergic receptor 1a ADRA1D ADRA1A protein protein human Homo sapiens Human MTFRDLLSVSFEGPRPDSSAGGSSAGGGGGSAGGAAPSEGPAVGGVPGGAGGGGGVVGAGSGEDNRSSAGEPGSAGAGGDVNGTAAVGGLVVSAQGVGVGVFLAAFILMAVAGNLLVILSVACNRHLQTVTNYFIVNLAVADLLLSATVLPFSATMEVLGFWAFGRAFCDVWAAVDVLCCTASILSLCTISVDRYVGVRHSLKYPAIMTERKAAAILALLWVVALVVSVGPLLGWKEPVPPDERFCGITEEAGYAVFSSVCSFYLPMAVIVVMYCRVYVVARSTTRSLEAGVKRERGKASEVVLRIHCRGAATGADGAHGMRSAKGHTFRSSLSVRLLKFSREKKAAKTLAIVVGVFVLCWFPFFFVLPLGSLFPQLKPSEGVFKVIFWLGYFNSCVNPLIYPCSSREFKRAFLRLLRCQCRRRRRRRPLWRVYGHHWRASTSGLRQDCAPSSGDAPPGAPLALTALPDPDPEPPGTPEMQAPVASRRKPPSAFREWRLLGPFRRPTTQLRAKVSSLSHKIRAGGAQRAEAACAQRSEVEAVSLGVPHEVAEGATCQAYELADYSNLRETDI EBEB134CF20A4988 pld3_human 5'-3' exonuclease PLD3 Choline phosphatase 3 HindIII K4L homolog Hu-K4 Phosphatidylcholine-hydrolyzing phospholipase D3 Phospholipase D3 PLD3 protein protein human Homo sapiens Human MKPKLMYQELKVPAEEPANELPMNEIEAWKAAEKKARWVLLVLILAVVGFGALMTQLFLWEYGDLHLFGPNQRPAPCYDPCEAVLVESIPEGLDFPNASTGNPSTSQAWLGLLAGAHSSLDIASFYWTLTNNDTHTQEPSAQQGEEVLRQLQTLAPKGVNVRIAVSKPSGPQPQADLQALLQSGAQVRMVDMQKLTHGVLHTKFWVVDQTHFYLGSANMDWRSLTQVKELGVVMYNCSCLARDLTKIFEAYWFLGQAGSSIPSTWPRFYDTRYNQETPMEICLNGTPALAYLASAPPPLCPSGRTPDLKALLNVVDNARSFIYVAVMNYLPTLEFSHPHRFWPAIDDGLRRATYERGVKVRLLISCWGHSEPSMRAFLLSLAALRDNHTHSDIQVKLFVVPADEAQARIPYARVNHNKYMVTERATYIGTSNWSGNYFTETAGTSLLVTQNGRGGLRSQLEAIFLRDWDSPYSHDLDTSADSVGNACRLL 444EC4D02F5610F1 cskp_human Peripheral plasma membrane protein CASK CASK LIN2 Calcium/calmodulin-dependent serine protein kinase Protein lin-2 homolog protein protein human Homo sapiens Human MADDDVLFEDVYELCEVIGKGPFSVVRRCINRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMLKHPHIVELLETYSSDGMLYMVFEFMDGADLCFEIVKRADAGFVYSEAVASHYMRQILEALRYCHDNNIIHRDVKPHCVLLASKENSAPVKLGGFGVAIQLGESGLVAGGRVGTPHFMAPEVVKREPYGKPVDVWGCGVILFILLSGCLPFYGTKERLFEGIIKGKYKMNPRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWLKERDRYAYKIHLPETVEQLRKFNARRKLKGAVLAAVSSHKFNSFYGDPPEELPDFSEDPTSSGLLAAERAVSQVLDSLEEIHALTDCSEKDLDFLHSVFQDQHLHTLLDLYDKINTKSSPQIRNPPSDAVQRAKEVLEEISCYPENNDAKELKRILTQPHFMALLQTHDVVAHEVYSDEALRVTPPPTSPYLNGDSPESANGDMDMENVTRVRLVQFQKNTDEPMGITLKMNELNHCIVARIMHGGMIHRQGTLHVGDEIREINGISVANQTVEQLQKMLREMRGSITFKIVPSYRTQSSSCERDSPSTSRQSPANGHSSTNNSVSDLPSTTQPKGRQIYVRAQFEYDPAKDDLIPCKEAGIRFRVGDIIQIISKDDHNWWQGKLENSKNGTAGLIPSPELQEWRVACIAMEKTKQEQQASCTWFGKKKKQYKDKYLAKHNAVFDQLDLVTYEEVVKLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMMQDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQALKVLRTAEFAPFVVFIAAPTITPGLNEDESLQRLQKESDILQRTYAHYFDLTIINNEIDETIRHLEEAVELVCTAPQWVPVSWVY 6C02008CE52728BA sntb2_human Beta-2-syntrophin SNT2B2 SNTB2 D16S2531E SNTL 59 kDa dystrophin-associated protein A1 basic component 2 Syntrophin-3 Syntrophin-like protein protein human Homo sapiens Human MRVAAATAAAGAGPAMAVWTRATKAGLVELLLRERWVRVVAELSGESLSLTGDAAAAELEPALGPAAAAFNGLPNGGGAGDSLPGSPSRGLGPPSPPAPPRGPAGEAGASPPVRRVRVVKQEAGGLGISIKGGRENRMPILISKIFPGLAADQSRALRLGDAILSVNGTDLRQATHDQAVQALKRAGKEVLLEVKFIREVTPYIKKPSLVSDLPWEGAAPQSPSFSGSEDSGSPKHQNSTKDRKIIPLKMCFAARNLSMPDLENRLIELHSPDSRNTLILRCKDTATAHSWFVAIHTNIMALLPQVLAELNAMLGATSTAGGSKEVKHIAWLAEQAKLDGGRQQWRPVLMAVTEKDLLLYDCMPWTRDAWASPCHSYPLVATRLVHSGSGCRSPSLGSDLTFATRTGSRQGIEMHLFRVETHRDLSSWTRILVQGCHAAAELIKEVSLGCMLNGQEVRLTIHYENGFTISRENGGSSSILYRYPFERLKMSADDGIRNLYLDFGGPEGELTMDLHSCPKPIVFVLHTFLSAKVTRMGLLV 53A9F3340DC024ED wrip1_human ATPase WRNIP1 WRNIP1 WHIP Werner helicase-interacting protein 1 protein protein human Homo sapiens Human MEVSGPEDDPFLSQLHQVQCPVCQQMMPAAHINSHLDRCLLLHPAGHAEPAAGSHRAGERAKGPSPPGAKRRRLSESSALKQPATPTAAESSEGEGEEGDDGGETESRESYDAPPTPSGARLIPDFPVARSSSPGRKGSGKRPAAAAAAGSASPRSWDEAEAQEEEEAVGDGDGDGDADADGEDDPGHWDADAAEAATAFGASGGGRPHPRALAAEEIRQMLQGKPLADTMRPDTLQDYFGQSKAVGQDTLLRSLLETNEIPSLILWGPPGCGKTTLAHIIASNSKKHSIRFVTLSATNAKTNDVRDVIKQAQNEKSFFKRKTILFIDEIHRFNKSQQDTFLPHVECGTITLIGATTENPSFQVNAALLSRCRVIVLEKLPVEAMVTILMRAINSLGIHVLDSSRPTDPLSHSSNSSSEPAMFIEDKAVDTLAYLSDGDARAGLNGLQLAVLARLSSRKMFCKKSGQSYSPSRVLITENDVKEGLQRSHILYDRAGEEHYNCISALHKSMRGSDQNASLYWLARMLEGGEDPLYVARRLVRFASEDIGLADPSALTQAVAAYQGCHFIGMPECEVLLAQCVVYFARAPKSIEVYSAYNNVKACLRNHQGPLPPVPLHLRNAPTRLMKDLGYGKGYKYNPMYSEPVDQEYLPEELRGVDFFKQRRC DE43D8E59C4B29E8 dlg1_human Disks large homolog 1 DLG1 Synapse-associated protein 97 hDlg protein protein human Homo sapiens Human MPVRKQDTQRALHLLEEYRSKLSQTEDRQLRSSIERVINIFQSNLFQALIDIQEFYEVTLLDNPKCIDRSKPSEPIQPVNTWEISSLPSSTVTSETLPSSLSPSVEKYRYQDEDTPPQEHISPQITNEVIGPELVHVSEKNLSEIENVHGFVSHSHISPIKPTEAVLPSPPTVPVIPVLPVPAENTVILPTIPQANPPPVLVNTDSLETPTYVNGTDADYEYEEITLERGNSGLGFSIAGGTDNPHIGDDSSIFITKIITGGAAAQDGRLRVNDCILRVNEVDVRDVTHSKAVEALKEAGSIVRLYVKRRKPVSEKIMEIKLIKGPKGLGFSIAGGVGNQHIPGDNSIYVTKIIEGGAAHKDGKLQIGDKLLAVNNVCLEEVTHEEAVTALKNTSDFVYLKVAKPTSMYMNDGYAPPDITNSSSQPVDNHVSPSSFLGQTPASPARYSPVSKAVLGDDEITREPRKVVLHRGSTGLGFNIVGGEDGEGIFISFILAGGPADLSGELRKGDRIISVNSVDLRAASHEQAAAALKNAGQAVTIVAQYRPEEYSRFEAKIHDLREQMMNSSISSGSGSLRTSQKRSLYVRALFDYDKTKDSGLPSQGLNFKFGDILHVINASDDEWWQARQVTPDGESDEVGVIPSKRRVEKKERARLKTVKFNSKTRDKGEIPDDMGSKGLKHVTSNASDSESSYRGQEEYVLSYEPVNQQEVNYTRPVIILGPMKDRINDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEHKFIEAGQYNNHLYGTSVQSVREVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEMNKRLTEEQARKTFERAMKLEQEFTEHFTAIVQGDTLEDIYNQVKQIIEEQSGSYIWVPAKEKL DIP protein Q12959 original sequence version: 178 6722993A84D0F761 scrib_human Protein scribble homolog SCRIB CRIB1 KIAA0147 LAP4 SCRB1 VARTUL Protein LAP4 protein protein human Homo sapiens Human MLKCIPLWRCNRHVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQRLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNLKALWLAENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPPSLEDAGQQGSLSETWSDAPPSRVSVIQFLEAPIGDEDAEEAAAEKRGLQRRATPHPSELKVMKRSIEGRRSEACPCQPDSGSPLPAEEEKRLSAESGLSEDSRPSASTVSEAEPEGPSAEAQGGSQQEATTAGGEEDAEEDYQEPTVHFAEDALLPGDDREIEEGQPEAPWTLPGGRQRLIRKDTPHYKKHFKISKLPQPEAVVALLQGMQPDGEGPVAPGGWHNGPHAPWAPRAQKEEEEEEEGSPQEEEVEEEEENRAEEEEASTEEEDKEGAVVSAPSVKGVSFDQANNLLIEPARIEEEELTLTILRQTGGLGISIAGGKGSTPYKGDDEGIFISRVSEEGPAARAGVRVGDKLLEVNGVALQGAEHHEAVEALRGAGTAVQMRVWRERMVEPENAVTITPLRPEDDYSPRERRGGGLRLPLLPPESPGPLRQRHVACLARSERGLGFSIAGGKGSTPYRAGDAGIFVSRIAEGGAAHRAGTLQVGDRVLSINGVDVTEARHDHAVSLLTAASPTIALLLEREAGGPLPPSPLPHSSPPTAAVATTSITTATPGVPGLPSLAPSLLAAALEGPYPVEEIRLPRAGGPLGLSIVGGSDHSSHPFGVQEPGVFISKVLPRGLAARSGLRVGDRILAVNGQDVRDATHQEAVSALLRPCLELSLLVRRDPAPPGLRELCIQKAPGERLGISIRGGARGHAGNPRDPTDEGIFISKVSPTGAAGRDGRLRVGLRLLEVNQQSLLGLTHGEAVQLLRSVGDTLTVLVCDGFEASTDAALEVSPGVIANPFAAGIGHRNSLESISSIDRELSPEGPGKEKELPGQTLHWGPEATEAAGRGLQPLKLDYRALAAVPSAGSVQRVPSGAAGGKMAESPCSPSGQQPPSPPSPDELPANVKQAYRAFAAVPTSHPPEDAPAQPPTPGPAASPEQLSFRERQKYFELEVRVPQAEGPPKRVSLVGADDLRKMQEEEARKLQQKRAQMLREAAEAGAEARLALDGETLGEEEQEDEQPPWASPSPTSRQSPASPPPLGGGAPVRTAKAERRHQERLRVQSPEPPAPERALSPAELRALEAEKRALWRAARMKSLEQDALRAQMVLSRSQEGRGTRGPLERLAEAPSPAPTPSPTPVEDLGPQTSTSPGRLSPDFAEELRSLEPSPSPGPQEEDGEVALVLLGRPSPGAVGPEDVALCSSRRPVRPGRRGLGPVPS DIP protein Q14160 original sequence version: 104 DIP protein Q14160 original sequence version: 139 D71E024FBC4F72D1 ssr3_human Somatostatin receptor type 3 SSTR3 SSR-28 protein protein human Homo sapiens Human MDMLHPSSVSTTSEPENASSAWPPDATLGNVSAGPSPAGLAVSGVLIPLVYLVVCVVGLLGNSLVIYVVLRHTASPSVTNVYILNLALADELFMLGLPFLAAQNALSYWPFGSLMCRLVMAVDGINQFTSIFCLTVMSVDRYLAVVHPTRSARWRTAPVARTVSAAVWVASAVVVLPVVVFSGVPRGMSTCHMQWPEPAAAWRAGFIIYTAALGFFGPLLVICLCYLLIVVKVRSAGRRVWAPSCQRRRRSERRVTRMVVAVVALFVLCWMPFYVLNIVNVVCPLPEEPAFFGLYFLVVALPYANSCANPILYGFLSYRFKQGFRRVLLRPSRRVRSQEPTVGPPEKTEEEDEEEEDGEESREGGKGKEMNGRVSQITQPGTSGQERPPSRVASKEQQLLPQEASTGEKSSTMRISYL 1227095F801190C4 ssr4_human Somatostatin receptor type 4 SSTR4 protein protein human Homo sapiens Human MSAPSTLPPGGEEGLGTAWPSAANASSAPAEAEEAVAGPGDARAAGMVAIQCIYALVCLVGLVGNALVIFVILRYAKMKTATNIYLLNLAVADELFMLSVPFVASSAALRHWPFGSVLCRAVLSVDGLNMFTSVFCLTVLSVDRYVAVVHPLRAATYRRPSVAKLINLGVWLASLLVTLPIAIFADTRPARGGQAVACNLQWPHPAWSAVFVVYTFLLGFLLPVLAIGLCYLLIVGKMRAVALRAGWQQRRRSEKKITRLVLMVVVVFVLCWMPFYVVQLLNLFVTSLDATVNHVSLILSYANSCANPILYGFLSDNFRRFFQRVLCLRCCLLEGAGGAEEEPLDYYATALKSKGGAGCMCPPLPCQQEALQPEPGRKRIPLTRTTTF DFCD9393620EDFC9 cxcr2_human C-X-C chemokine receptor type 2 CXCR2 IL8RB CDw128b GRO/MGSA receptor High affinity interleukin-8 receptor B IL-8 receptor type 2 protein protein human Homo sapiens Human MEDFNMESDSFEDFWKGEDLSNYSYSSTLPPFLLDAAPCEPESLEINKYFVVIIYALVFLLSLLGNSLVMLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVNFYSGILLLACISVDRYLAIVHATRTLTQKRYLVKFICLSIWGLSLLLALPVLLFRRTVYSSNVSPACYEDMGNNTANWRMLLRILPQSFGFIVPLLIMLFCYGFTLRTLFKAHMGQKHRAMRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQETCERRNHIDRALDATEILGILHSCLNPLIYAFIGQKFRHGLLKILAIHGLISKDSLPKDSRPSFVGSSSGHTSTTL DIP protein P25025 original sequence version: 138 564F04A8BCC0A197 dtnb_human Dystrobrevin beta DTNB Beta-dystrobrevin protein protein human Homo sapiens Human MIEESGNKRKTMAEKRQLFIEMRAQNFDVIRLSTYRTACKLRFVQKRCNLHLVDIWNMIEAFRDNGLNTLDHTTEISVSRLETVISSIYYQLNKRLPSTHQISVEQSISLLLNFMIAAYDSEGRGKLTVFSVKAMLATMCGGKMLDKLRYVFSQMSDSNGLMIFSKFDQFLKEVLKLPTAVFEGPSFGYTEHSVRTCFPQQRKIMLNMFLDTMMADPPPQCLVWLPLMHRLAHVENVFHPVECSYCRCESMMGFRYRCQQCHNYQLCQNCFWRGHAGGPHSNQHQMKEHSSWKSPAKKLSHAISKSLGCVPTREPPHPVFPEQPEKPLDLAHIVPPRPLTNMNDTMVSHMSSGVPTPTKRLQYSQDIPSHLADEHALIASYVARLQHCARVLDSPSRLDEEHRLIARYAARLAAEAGNVTRPPTDLSFNFDANKQQRQLIAELENKNREILQEIQRLRLEHEQASQPTPEKAQQNPTLLAELRLLRQRKDELEQRMSALQESRRELMVQLEELMKLLKEEEQKQAAQATGSPHTSPTHGGGRPMPMPVRSTSAGSTPTHCPQDSLSGVGGDVQEAFAQGTRRNLRNDLLVAADSITNTMSSLVKELHSAEEGAEEEEEKMQNGKDRG 6927EC0BD86D375C pp1g_human Serine/threonine-protein phosphatase PP1-gamma catalytic subunit PPP1CC Protein phosphatase 1C catalytic subunit protein protein human Homo sapiens Human MADLDKLNIDSIIQRLLEVRGSKPGKNVQLQENEIRGLCLKSREIFLSQPILLELEAPLKICGDIHGQYYDLLRLFEYGGFPPESNYLFLGDYVDRGKQSLETICLLLAYKIKYPENFFLLRGNHECASINRIYGFYDECKRRYNIKLWKTFTDCFNCLPIAAIVDEKIFCCHGGLSPDLQSMEQIRRIMRPTDVPDQGLLCDLLWSDPDKDVLGWGENDRGVSFTFGAEVVAKFLHKHDLDLICRAHQVVEDGYEFFAKRQLVTLFSAPNYCGEFDNAGAMMSVDETLMCSFQILKPAEKKKPNATRPVTPPRGMITKQAKK DIP protein P36873 original sequence version: 169 DIP protein P36873 original sequence version: 177 0EEEF0E842188536 1433b_human 14-3-3 protein beta/alpha YWHAB Protein kinase C inhibitor protein 1 Protein 1054 protein protein human Homo sapiens Human MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLIPNATQPESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN DIP protein P31946 original sequence version: 171 DIP protein P31946 original sequence version: 97 DIP protein P31946 original sequence version: 119 DIP protein P31946 original sequence version: 122 DIP protein P31946 original sequence version: 180 6BE1A9BF97468017 lin7c_human Protein lin-7 homolog C Mammalian lin-seven protein 3 Vertebrate lin-7 homolog 3 LIN7C MALS3 VELI3 protein protein human Homo sapiens Human MAALGEPVRLERDICRAIELLEKLQRSGEVPPQKLQALQRVLQSEFCNAVREVYEHVYETVDISSSPEVRANATAKATVAAFAASEGHSHPRVVELPKTEEGLGFNIMGGKEQNSPIYISRIIPGGIADRHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAQGKVKLVVRYTPKVLEEMESRFEKMRSAKRRQQT 7410FBFA3BD24F45 mas_human Proto-oncogene Mas MAS1 MAS protein protein human Homo sapiens Human MDGSNVTSFVVEEPTNISTGRNASVGNAHRQIPIVHWVIMSISPVGFVENGILLWFLCFRMRRNPFTVYITHLSIADISLLFCIFILSIDYALDYELSSGHYYTIVTLSVTFLFGYNTGLYLLTAISVERCLSVLYPIWYRCHRPKYQSALVCALLWALSCLVTTMEYVMCIDREEESHSRNDCRAVIIFIAILSFLVFTPLMLVSSTILVVKIRKNTWASHSSKLYIVIMVTIIIFLIFAMPMRLLYLLYYEYWSTFGNLHHISLLFSTINSSANPFIYFFVGSSKKKRFKESLKVVLTRAFKDEMQPRRQKDNCNTVTVETVV 3368E7B174744B83 galr1_human Galanin receptor type 1 GALR1 GALNR GALNR1 protein protein human Homo sapiens Human MELAVGNLSEGNASWPEPPAPEPGPLFGIGVENFVTLVVFGLIFALGVLGNSLVITVLARSKPGKPRSTTNLFILNLSIADLAYLLFCIPFQATVYALPTWVLGAFICKFIHYFFTVSMLVSIFTLAAMSVDRYVAIVHSRRSSSLRVSRNALLGVGCIWALSIAMASPVAYHQGLFHPRASNQTFCWEQWPDPRHKKAYVVCTFVFGYLLPLLLICFCYAKVLNHLHKKLKNMSKKSEASKKKTAQTVLVVVVVFGISWLPHHIIHLWAEFGVFPLTPASFLFRITAHCLAYSNSSVNPIIYAFLSENFRKAYKQVFKCHIRKDSHLSDTKESKSRIDTPPSTNCTHV A0664227157B3410 pdzd8_human PDZ domain-containing protein 8 PDZD8 PDZK8 Sarcoma antigen NY-SAR-84/NY-SAR-104 protein protein human Homo sapiens Human MGLLLMILASAVLGSFLTLLAQFFLLYRRQPEPPADEAARAGEGFRYIKPVPGLLLREYLYGGGRDEEPSGAAPEGGATPTAAPETPAPPTRETCYFLNATILFLFRELRDTALTRRWVTKKIKVEFEELLQTKTAGRLLEGLSLRDVFLGETVPFIKTIRLVRPVVPSATGEPDGPEGEALPAACPEELAFEAEVEYNGGFHLAIDVDLVFGKSAYLFVKLSRVVGRLRLVFTRVPFTHWFFSFVEDPLIDFEVRSQFEGRPMPQLTSIIVNQLKKIIKRKHTLPNYKIRFKPFFPYQTLQGFEEDEEHIHIQQWALTEGRLKVTLLECSRLLIFGSYDREANVHCTLELSSSVWEEKQRSSIKTVELIKGNLQSVGLTLRLVQSTDGYAGHVIIETVAPNSPAAIADLQRGDRLIAIGGVKITSTLQVLKLIKQAGDRVLVYYERPVGQSNQGAVLQDNFGQLEENFLSSSCQSGYEEEAAGLTVDTESRELDSEFEDLASDVRAQNEFKDEAQSLSHSPKRVPTTLSIKPLGAISPVLNRKLAVGSHPLPPKIQSKDGNKPPPLKTSEITDPAQVSKPTQGSAFKPPVPPRPQAKVPLPSADAPNQAEPDVLVEKPEKVVPPPLVDKSAEKQAKNVDAIDDAAAPKQFLAKQEVAKDVTSETSCPTKDSSDDRQTWESSEILYRNKLGKWTRTRASCLFDIEACHRYLNIALWCRDPFKLGGLICLGHVSLKLEDVALGCLATSNTEYLSKLRLEAPSPKAIVTRTALRNLSMQKGFNDKFCYGDITIHFKYLKEGESDHHVVTNVEKEKEPHLVEEVSVLPKEEQFVGQMGLTENKHSFQDTQFQNPTWCDYCKKKVWTKAASQCMFCAYVCHKKCQEKCLAETSVCGATDRRIDRTLKNLRLEGQETLLGLPPRVDAEASKSVNKTTGLTRHIINTSSRLLNLRQVSKTRLSEPGTDLVEPSPKHTPNTSDNEGSDTEVCGPNSPSKRGNSTGIKLVRKEGGLDDSVFIAVKEIGRDLYRGLPTEERIQKLEFMLDKLQNEIDQELEHNNSLVREEKETTDTRKKSLLSAALAKSGERLQALTLLMIHYRAGIEDIETLESLSLDQHSKKISKYTDDTEEDLDNEISQLIDSQPFSSISDDLFGPSESV B09263C483645B13 lin7a_human Protein lin-7 homolog A LIN7A MALS1 VELI1 Mammalian lin-seven protein 1 Vertebrate lin-7 homolog 1 Tax interaction protein 33 protein protein human Homo sapiens Human MLKPSVTSAPTADMATLTVVQPLTLDRDVARAIELLEKLQESGEVPVHKLQSLKKVLQSEFCTAIREVYQYMHETITVNGCPEFRARATAKATVAAFAASEGHSHPRVVELPKTDEGLGFNVMGGKEQNSPIYISRIIPGGVAERHGGLKRGDQLLSVNGVSVEGEHHEKAVELLKAAKDSVKLVVRYTPKVLEEMEARFEKLRTARRRQQQQLLIQQQQQQQQQQTQQNHMS D8D05EF16A93BE7B arhg7_human Rho guanine nucleotide exchange factor 7 PAK-interacting exchange factor beta Beta-Pix COOL-1 p85 Nbla10314 ARHGEF7 COOL1 KIAA0142 P85SPR PAK3BP PIXB protein protein human Homo sapiens Human MNSAEQTVTWLITLGVLESPKKTISDPEGFLQASLKDGVVLCRLLERLLPGTIEKVYPEPRSESECLSNIREFLRGCGASLRLELLFPPSQPPQHLVTTILLSASTFDANDLYQGQNFNKVLSSLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLGSQSLHTRTSKLFQGQYRSLDMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLSSANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQQRVGGCFLNLMPQMKTLYLTYCANHPSAVNVLTEHSEELGEFMETKGASSPGILVLTTGLSKPFMRLDKYPTLLKELERHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKELELQILTEAIRNWEGDDIKTLGNVTYMSQVLIQCAGSEEKNERYLLLFPNVLLMLSASPRMSGFIYQGKLPTTGMTITKLEDSENHRNAFEISGSMIERILVSCNNQQDLQEWVEHLQKQTKVTSVGNPTIKPHSVPSHTLPSHPVTPSSKHADSKPAPLTPAYHTLPHPSHHGTPHTTINWGPLEPPKTPKPWSLSCLRPAPPLRPSAALCYKEDLSKSPKTMKKLLPKRKPERKPSDEEFASRKSTAALEEDAQILKVIEAYCTSAKTRQTLNSTWQGTDLMHNHVLADDDQPSLDSLGRRSSLSRLEPSDLSEDSDYDSIWTAHSYRMGSTSRKSCCSYISHQN DIP protein Q14155 original sequence version: 163 DIP protein Q14155 original sequence version: 159 613EBA839E6FDBFD adra1d-ctnnal1-19 4 28 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 29 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 10 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 30 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 39 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 15 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 42 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Table 1-1, Table 2 adra1d-ctnnal1-1 4 40 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association Table 1-2 htr2a-wrnip1-1 4 35 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 40 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level physical association physical association Table 1-3 htr2b-wrnip1-1 4 31 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 26 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association Table 1-4 sstr1-gopc-1 4 17 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 19 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 43 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Table 1-5 sstr3-csnk2a1-1 4 32 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 21 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 48 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 44 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Table 1-6 sstr1-gopc-2 4 24 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 31 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 23 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Table 1-8 cxcr3-gopc-1 4 13 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 45 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association Table 1-7 cxcr3-ghdc-1 4 24 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 16 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association Table 1-9 sstr1-gopc-3 4 52 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 51 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association Table 1-10 sstr3-csnk2a1-2 4 37 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 25 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 49 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 41 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 38 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 14 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Table 1-11 cysltr2-cask-1 4 22 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 41 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 38 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 50 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Table 1-12 adra1d-ctnnal1-2 7 42 anti tag western anti tag western blot anti tag western western blot western blot Immuno blot Immuno blot unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Figure 1A Lane 3 ADRA1D interacted with both endogenous and ectopic SCRIB (Figure 1a, ADRA1D interacted with both endogenous and ectopic SCRIB (Figure 1a, lanes 2 and 3). In Lane 4 CLIP tagged SCRIB may be present as well as endogenous SCRIB. ADRA1D is mostly expressed as homodimers or higher-order oligomers. adra1d-scrib-1 3 36 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level 9 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level 42 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level colocalization colocalization Figure 1B ADRA1D and SCRIB co-localize at the plasma membrane and within the cell adra1d-scrib-2 7 42 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range PDZ_ligand_domain required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain physical association physical association Figure 1C-Lane 1, Fig 1A lane 2, Figure 3B Lane 4, Figure 2A/B I am assuming figure 2A/B should go here - it is not stated if SCRIB was endogenous or not, while SNTA is explicitly stated to have been transfected. Maybe figure 2A/B should not be entered at all? adra1d-scrib-3 7 9 competitor competitor competitor prey prey over-expressed over expressed level over-expressed 42 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Figure 1C-Lane 2, Figure 2 A/B Overexpressing SNTA competes away SCRIB:ADRA1D binding (lane 2). adra1d-scrib-4 7 9 competitor competitor competitor prey prey over-expressed over expressed level over-expressed 42 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Figure 1C-Lane 4 Co-overexpressing SNTA and SCRIB substantially diminishes SCRIB:ADRA1D binding (lane 4). adra1d-scrib-5 7 42 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association Figure 1C-Lane 3 Lane 3: over expressed SCRIB alone. adra1d-ctnnal1-4 1 46 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 28 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 29 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 9 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 30 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 39 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 15 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 42 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Table 2-2 adra1d-ctnnal1-5 5 18 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 28 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 46 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 10 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 39 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 42 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Table 2-3 adra1d-ctnnal1-6 6 28 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 29 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 10 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 39 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 18 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 42 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 34 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 46 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level association association Table 2-4 adra1d-ctnnal1-7 2 28 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 29 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 10 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 39 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 42 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 46 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level association association Table 2-5 adra1d-ctnnal1-8 8 28 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 29 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 39 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 15 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 42 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 27 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 41 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 30 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 20 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 53 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 38 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 46 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level association association Table 2-6 adra1d-scrib-6 7 36 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Figure 3A/B Lane 2 Myc–ADRA1D was mainly detected at M.Wt >140kDa- in multimers. snta1-adra1d-1 7 36 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 42 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed 9 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range association association Figure 3A Lane 4 A SNTA-ADRA1D complex can recruit SCRIB Myc–ADRA1D was mainly detected at M.Wt >140kDa- in multimers. a SNTA-ADRA1D complex can recruit SCRIB adra1d-adra1d-2 7 36 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region excluding PDZ_ligand sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association Figure 3B Lane 5 Myc–ADRA1D was mainly detected at M.Wt >140kDa- in multimers. adra1d-ctnnal1-9 4 47 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 33 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 54 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 28 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 29 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed 42 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 39 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level association association Table 3-2 Interaction in the presence of Wild Type ADRA1D. scrib-adra1d-2 4 47 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 42 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 33 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 54 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 11 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level association association Table 3-1 Interaction in the absence of ADRA1D and in the presence of ADRA1D–DeltaPDZ. scrib-adra1d-3 4 28 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 29 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed PDZ_ligand_domain required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain 42 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range 39 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level association association Table 3-3 Interaction which requires the presence of PDZ ligand domain of ADRA1D. adra1d-ctnnal1-10 4 36 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 28 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 29 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 10 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 39 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 15 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range region excluding PDZ_ligand sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain association association Table 4 SCRIB or syntrophin interactions must occur through an ADRA1D dimer containing Myc–ADRA1D, as TAP–ADRA1D-ΔPDZ is unable to interact with either PDZ protein (Table 4 if my reading of Table 4 (bottom interaction) is correct both SCRIB and CTNNAL1 have "a" by them = No protein detected;text states tgat "SCRIB was not" just above Table 4. adra1d-adra1d-1 4 28 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 29 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 10 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 30 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 39 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 15 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 42 unspecified role unspecified role prey prey physiological level physiological level endogenous level endogenous endogenous endogenous level 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range PDZ_ligand_domain required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain association association Table 4-1 adra1d-scrib-7 7 9 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed 36 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed n-terminus strep tag strep tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range n-terminus cam tag calmodulin binding protein tag cam tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range physical association physical association Figure 1C-Lane 2