DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Design of amidobenzimidazole STING receptor agonists with systemic activity. Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature 2018 imex curation Ramanjulu JM., Pesiridis GS., Yang J., Concha N., Singhaus R., Zhang SY., Tran JL., Moore P., Lehmann S., Eberl HC., Muelbaier M., Schneck JL., Clemens J., Adam M., Mehlmann J., Romano J., Morales A., Kang J., Leister L., Graybill TL., Charnley AK., Ye G., Nevins N., Behnia K., Wolf AI., Kasparcova V., Nurse K., Wang L., Li Y., Klein M., Hopson CB., Guss J., Bantscheff M., Bergamini G., Reilly MA., Lian Y., Duffy KJ., Adams J., Foley KP., Gough PJ., Marquis RW., Smothers J., Hoos A., Bertin J. joshi.m.ramanjulu@gsk.com 09-May-2019: Contacted by IntAct-Help. Only protein-protein interactions imex curation ecoli Escherichia coli (strain K12) x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction experimental particp experimental participant identification experimental particp Ramanjulu JM., Pesiridis GS., Yang J., Concha N., Singhaus R., Zhang SY., Tran JL., Moore P., Lehmann S., Eberl HC., Muelbaier M., Schneck JL., Clemens J., Adam M., Mehlmann J., Romano J., Morales A., Kang J., Leister L., Graybill TL., Charnley AK., Ye G., Nevins N., Behnia K., Wolf AI., Kasparcova V., Nurse K., Wang L., Li Y., Klein M., Hopson CB., Guss J., Bantscheff M., Bergamini G., Reilly MA., Lian Y., Duffy KJ., Adams J., Foley KP., Gough PJ., Marquis RW., Smothers J., Hoos A., Bertin J. joshi.m.ramanjulu@gsk.com Accepted 2018-DEC-17 AT 10:17 GMT AT 10:17 GMT by ORCHARD Nature 2018 imex curation sting_human Stimulator of interferon genes protein STING1 ERIS Endoplasmic reticulum interferon stimulator MITA Mediator of IRF3 activation TMEM173 Transmembrane protein 173 protein protein human Homo sapiens Human MPHSSLHPSIPCPRGHGAQKAALVLLSACLVTLWGLGEPPEHTLRYLVLHLASLQLGLLLNGVCSLAEELRHIHSRYRGSYWRTVRACLGCPLRRGALLLLSIYFYYSLPNAVGPPFTWMLALLGLSQALNILLGLKGLAPAEISAVCEKGNFNVAHGLAWSYYIGYLRLILPELQARIRTYNQHYNNLLRGAVSQRLYILLPLDCGVPDNLSMADPNIRFLDKLPQQTGDHAGIKDRVYSNSIYELLENGQRAGTCVLEYATPLQTLFAMSQYSQAGFSREDRLEQAKLFCRTLEDILADAPESQNNCRLIAYQEPADDSSFSLSQEVLRHLRQEEKEEVTVGSLKTSAVPSTSTMSQEPELLISGMEKPLPLRTDFS DIP protein Q86WV6 original sequence version: 83 DIP protein Q86WV6 original sequence version: 47 DIP protein Q86WV6 original sequence version: 50 DIP protein Q86WV6 original sequence version: 100 DIP protein Q86WV6 original sequence version: 68 CB54D6A4D4D8E7C0 sting-1 1 2 predetermined predetermined participant predetermined experimental particp experimental participant identification experimental particp unspecified role unspecified role neutral component neutral component purified purified binding region binding region binding region binding-associated region binding region certain certain sequence position certain certain certain sequence position certain ecoli Escherichia coli (strain K12) direct interaction direct interaction Fig 1, Extended Data Table 2