IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. PloS one 2010 imex curation Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg 17-May-2018: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-hct116 Human colon carcinoma HCT116 cells hct116 Human colon carcinoma line HCT116 confocal microscopy confocal microscopy immunocytochemistry immunocytochemistry Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. I have not entered any results from Fig 5iv- SW480 cells, as they are only showing co-loc of GFP-"Actin" and endogenous APC - not CDC42, although that might also be co-localised? APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg Accepted 2018-APR-16 AT 12:15 BST AT 12:15 BST by LIVIAP PloS one 2010 Only protein-protein interactions imex curation imex curation We only enter the library for the Screen( - which I have done in the other experiment)- not for any subsequent "predetermined" assays like this one. I added APC 222-653 as the text states:- "....were purified and used in complementation assays with Cdc42 to confirm the interactions in a clean yeast background. Among the clones was one of two identical clones encoding a 431 aa fragment of APC (APC222–653) that was found to interact with Cdc42 in the Y2H library screens." (so maybe it should have been added for the screen as well???, but as it is not mentioned in Table S1 I did not.) Also text states :- "Thus the full sequence of the APC222–653 fragment found in the Y2H screen is necessary for a strong Cdc42 interaction". and text above Figure 2:- " APC222–653 gave rise to colonies that grew on QDO medium and turned blue in the β-galactosidase assay with color intensity scores of (+++++) similar to that obtained for the positive control (Fig. 2(i),". Although the APC_222-653 construct is not mentioned actually ON Figure 2i - the text states they used it. Methods section does not mention the 222-653 construct, or any construct at all, for Y2H.; I have removed the IRSp53 binding region as I cannot find it either. I have added "partially-purified" to the In Vitro proteins. (I did not add anything for Bait as there is no info given, but I suppose it is OK to add "purified" as it must be.) Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. PloS one 2010 imex curation Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg 17-May-2018: Contacted by IntAct-Help. Only protein-protein interactions imex curation crigr-cho chinese hamster ovary cell line cho chinese hamster ovary cell line Also called LR73 cells. fret fluorescent resonance energy transfer FRET RET FRET analysis FRET RET FRET analysis fret tag fluorescence tag visualisation by fluorescence tag fluorescence Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. FLIM-FRET(fluorescence lifetime imaging microscopy-FRET). GFP fluorescence lifetime of the interacting donor molecule is measured. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg Accepted 2018-APR-16 AT 12:15 BST AT 12:15 BST by LIVIAP PloS one 2010 Only protein-protein interactions imex curation imex curation We only enter the library for the Screen( - which I have done in the other experiment)- not for any subsequent "predetermined" assays like this one. I added APC 222-653 as the text states:- "....were purified and used in complementation assays with Cdc42 to confirm the interactions in a clean yeast background. Among the clones was one of two identical clones encoding a 431 aa fragment of APC (APC222–653) that was found to interact with Cdc42 in the Y2H library screens." (so maybe it should have been added for the screen as well???, but as it is not mentioned in Table S1 I did not.) Also text states :- "Thus the full sequence of the APC222–653 fragment found in the Y2H screen is necessary for a strong Cdc42 interaction". and text above Figure 2:- " APC222–653 gave rise to colonies that grew on QDO medium and turned blue in the β-galactosidase assay with color intensity scores of (+++++) similar to that obtained for the positive control (Fig. 2(i),". Although the APC_222-653 construct is not mentioned actually ON Figure 2i - the text states they used it. Methods section does not mention the 222-653 construct, or any construct at all, for Y2H.; I have removed the IRSp53 binding region as I cannot find it either. I have added "partially-purified" to the In Vitro proteins. (I did not add anything for Bait as there is no info given, but I suppose it is OK to add "purified" as it must be.) Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. PloS one 2010 imex curation Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg 17-May-2018: Contacted by IntAct-Help. Only protein-protein interactions imex curation crigr-cho chinese hamster ovary cell line cho chinese hamster ovary cell line Also called LR73 cells. fret fluorescent resonance energy transfer FRET RET FRET analysis FRET RET FRET analysis fret tag fluorescence tag visualisation by fluorescence tag fluorescence Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. beware: the acceptor/donor molecules swop between figs 2 and 3! Acceptor photobleaching-FRET APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg Accepted 2018-APR-16 AT 12:15 BST AT 12:15 BST by LIVIAP PloS one 2010 Only protein-protein interactions imex curation imex curation We only enter the library for the Screen( - which I have done in the other experiment)- not for any subsequent "predetermined" assays like this one. I added APC 222-653 as the text states:- "....were purified and used in complementation assays with Cdc42 to confirm the interactions in a clean yeast background. Among the clones was one of two identical clones encoding a 431 aa fragment of APC (APC222–653) that was found to interact with Cdc42 in the Y2H library screens." (so maybe it should have been added for the screen as well???, but as it is not mentioned in Table S1 I did not.) Also text states :- "Thus the full sequence of the APC222–653 fragment found in the Y2H screen is necessary for a strong Cdc42 interaction". and text above Figure 2:- " APC222–653 gave rise to colonies that grew on QDO medium and turned blue in the β-galactosidase assay with color intensity scores of (+++++) similar to that obtained for the positive control (Fig. 2(i),". Although the APC_222-653 construct is not mentioned actually ON Figure 2i - the text states they used it. Methods section does not mention the 222-653 construct, or any construct at all, for Y2H.; I have removed the IRSp53 binding region as I cannot find it either. I have added "partially-purified" to the In Vitro proteins. (I did not add anything for Bait as there is no info given, but I suppose it is OK to add "purified" as it must be.) Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. PloS one 2010 imex curation Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg 17-May-2018: Contacted by IntAct-Help. Only protein-protein interactions imex curation crigr-cho chinese hamster ovary cell line cho chinese hamster ovary cell line Also called LR73 cells. confocal microscopy confocal microscopy tag fluorescence tag visualisation by fluorescence tag fluorescence Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg Accepted 2018-APR-16 AT 12:15 BST AT 12:15 BST by LIVIAP PloS one 2010 Only protein-protein interactions imex curation imex curation We only enter the library for the Screen( - which I have done in the other experiment)- not for any subsequent "predetermined" assays like this one. I added APC 222-653 as the text states:- "....were purified and used in complementation assays with Cdc42 to confirm the interactions in a clean yeast background. Among the clones was one of two identical clones encoding a 431 aa fragment of APC (APC222–653) that was found to interact with Cdc42 in the Y2H library screens." (so maybe it should have been added for the screen as well???, but as it is not mentioned in Table S1 I did not.) Also text states :- "Thus the full sequence of the APC222–653 fragment found in the Y2H screen is necessary for a strong Cdc42 interaction". and text above Figure 2:- " APC222–653 gave rise to colonies that grew on QDO medium and turned blue in the β-galactosidase assay with color intensity scores of (+++++) similar to that obtained for the positive control (Fig. 2(i),". Although the APC_222-653 construct is not mentioned actually ON Figure 2i - the text states they used it. Methods section does not mention the 222-653 construct, or any construct at all, for Y2H.; I have removed the IRSp53 binding region as I cannot find it either. I have added "partially-purified" to the In Vitro proteins. (I did not add anything for Bait as there is no info given, but I suppose it is OK to add "purified" as it must be.) Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. PloS one 2010 imex curation Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg 17-May-2018: Contacted by IntAct-Help. Only protein-protein interactions imex curation yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid predetermined predetermined participant predetermined Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg Accepted 2018-APR-16 AT 12:15 BST AT 12:15 BST by LIVIAP PloS one 2010 Only protein-protein interactions imex curation imex curation We only enter the library for the Screen( - which I have done in the other experiment)- not for any subsequent "predetermined" assays like this one. I added APC 222-653 as the text states:- "....were purified and used in complementation assays with Cdc42 to confirm the interactions in a clean yeast background. Among the clones was one of two identical clones encoding a 431 aa fragment of APC (APC222–653) that was found to interact with Cdc42 in the Y2H library screens." (so maybe it should have been added for the screen as well???, but as it is not mentioned in Table S1 I did not.) Also text states :- "Thus the full sequence of the APC222–653 fragment found in the Y2H screen is necessary for a strong Cdc42 interaction". and text above Figure 2:- " APC222–653 gave rise to colonies that grew on QDO medium and turned blue in the β-galactosidase assay with color intensity scores of (+++++) similar to that obtained for the positive control (Fig. 2(i),". Although the APC_222-653 construct is not mentioned actually ON Figure 2i - the text states they used it. Methods section does not mention the 222-653 construct, or any construct at all, for Y2H.; I have removed the IRSp53 binding region as I cannot find it either. I have added "partially-purified" to the In Vitro proteins. (I did not add anything for Bait as there is no info given, but I suppose it is OK to add "purified" as it must be.) Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. PloS one 2010 imex curation Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg 17-May-2018: Contacted by IntAct-Help. Only protein-protein interactions imex curation in vitro In vitro pull down pull down weight autoradiogra molecular weight estimation by autoradiography weight autoradiogra Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg Accepted 2018-APR-16 AT 12:15 BST AT 12:15 BST by LIVIAP PloS one 2010 Only protein-protein interactions imex curation imex curation We only enter the library for the Screen( - which I have done in the other experiment)- not for any subsequent "predetermined" assays like this one. I added APC 222-653 as the text states:- "....were purified and used in complementation assays with Cdc42 to confirm the interactions in a clean yeast background. Among the clones was one of two identical clones encoding a 431 aa fragment of APC (APC222–653) that was found to interact with Cdc42 in the Y2H library screens." (so maybe it should have been added for the screen as well???, but as it is not mentioned in Table S1 I did not.) Also text states :- "Thus the full sequence of the APC222–653 fragment found in the Y2H screen is necessary for a strong Cdc42 interaction". and text above Figure 2:- " APC222–653 gave rise to colonies that grew on QDO medium and turned blue in the β-galactosidase assay with color intensity scores of (+++++) similar to that obtained for the positive control (Fig. 2(i),". Although the APC_222-653 construct is not mentioned actually ON Figure 2i - the text states they used it. Methods section does not mention the 222-653 construct, or any construct at all, for Y2H.; I have removed the IRSp53 binding region as I cannot find it either. I have added "partially-purified" to the In Vitro proteins. (I did not add anything for Bait as there is no info given, but I suppose it is OK to add "purified" as it must be.) Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. PloS one 2010 imex curation Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg 17-May-2018: Contacted by IntAct-Help. Only protein-protein interactions imex curation yeasx Saccharomyces cerevisiae (Baker's yeast) Baker's yeast 2 hybrid two hybrid 2H 2h Gal4 transcription regeneration two-hybrid yeast two hybrid 2-hybrid classical two hybrid classical two hybrid 2H two-hybrid 2-hybrid Gal4 transcription regeneration 2h yeast two hybrid Y2H Y-2H 2 hybrid nucleotide sequence nucleotide sequence identification sequence cloning sequence cloning nucleotide sequence Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. Table S1 only lists "novel" interactors. Some, but not all, previously known interactors are listed in the text above figure 1. The protein IRSp58 cannot be identified;it is most likely the same protein as IRSp53. Is stated that ""Nine human cDNA libraries" were used, but MOUSE Uniprot identifiers are given for the 11-day embryo results, so presumably only eight human libraries were used. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg Accepted 2018-APR-16 AT 12:15 BST AT 12:15 BST by LIVIAP Text states:- "Nine human cDNA libraries :- brain, fetal brain, bone marrow, heart, liver, kidney, ovary, testis and 11-day embryo were screened." PloS one 2010 Only protein-protein interactions imex curation imex curation We only enter the library for the Screen( - which I have done in the other experiment)- not for any subsequent "predetermined" assays like this one. I added APC 222-653 as the text states:- "....were purified and used in complementation assays with Cdc42 to confirm the interactions in a clean yeast background. Among the clones was one of two identical clones encoding a 431 aa fragment of APC (APC222–653) that was found to interact with Cdc42 in the Y2H library screens." (so maybe it should have been added for the screen as well???, but as it is not mentioned in Table S1 I did not.) Also text states :- "Thus the full sequence of the APC222–653 fragment found in the Y2H screen is necessary for a strong Cdc42 interaction". and text above Figure 2:- " APC222–653 gave rise to colonies that grew on QDO medium and turned blue in the β-galactosidase assay with color intensity scores of (+++++) similar to that obtained for the positive control (Fig. 2(i),". Although the APC_222-653 construct is not mentioned actually ON Figure 2i - the text states they used it. Methods section does not mention the 222-653 construct, or any construct at all, for Y2H.; I have removed the IRSp53 binding region as I cannot find it either. I have added "partially-purified" to the In Vitro proteins. (I did not add anything for Bait as there is no info given, but I suppose it is OK to add "purified" as it must be.) Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. Rho GTPase Cdc42 is a direct interacting partner of Adenomatous Polyposis Coli protein and can alter its cellular localization. PloS one 2010 imex curation Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg 17-May-2018: Contacted by IntAct-Help. Only protein-protein interactions imex curation human-sw480 Human SW480 adenocarcinoma cell line sw480 SW480- human primary colorectal adenocarcinoma cell line There is a G -> A mutation in codon 273 of the p53 gene resulting in an Arg -> His substitution and a C -> T mutation in codon 309 resulting in a Pro -> Ser substitution. http://www.atcc.org/ATCCAdvancedCatalogSearch/ProductDetails/tabid/452/Default.aspx?ATCCNum=CCL-228&Template=cellBiology pull down pull down western blot western blot Immuno blot Immuno blot Sudhaharan T., Goh WI., Sem KP., Lim KB., Bu W., Ahmed S. APC has been determined to be of Human origin due to sequence length. CDC42 was determined to be of Human origin by chasing references to PMID:11157984, and the fact that many mammalian CDC42 molecules appear to have an identical sequence.(Rat, Pig, Human, Mouse, Cow+). sohail.ahmed@imb.a-star.edu.sg Accepted 2018-APR-16 AT 12:15 BST AT 12:15 BST by LIVIAP PloS one 2010 Only protein-protein interactions imex curation imex curation We only enter the library for the Screen( - which I have done in the other experiment)- not for any subsequent "predetermined" assays like this one. I added APC 222-653 as the text states:- "....were purified and used in complementation assays with Cdc42 to confirm the interactions in a clean yeast background. Among the clones was one of two identical clones encoding a 431 aa fragment of APC (APC222–653) that was found to interact with Cdc42 in the Y2H library screens." (so maybe it should have been added for the screen as well???, but as it is not mentioned in Table S1 I did not.) Also text states :- "Thus the full sequence of the APC222–653 fragment found in the Y2H screen is necessary for a strong Cdc42 interaction". and text above Figure 2:- " APC222–653 gave rise to colonies that grew on QDO medium and turned blue in the β-galactosidase assay with color intensity scores of (+++++) similar to that obtained for the positive control (Fig. 2(i),". Although the APC_222-653 construct is not mentioned actually ON Figure 2i - the text states they used it. Methods section does not mention the 222-653 construct, or any construct at all, for Y2H.; I have removed the IRSp53 binding region as I cannot find it either. I have added "partially-purified" to the In Vitro proteins. (I did not add anything for Bait as there is no info given, but I suppose it is OK to add "purified" as it must be.) zmy11_human Zinc finger MYND domain-containing protein 11 BRAM1 Bone morphogenetic protein receptor-associated molecule 1 ZMYND11 Adenovirus 5 E1A-binding protein BS69 Protein BS69 protein protein human Homo sapiens Human MARLTKRRQADTKAIQHLWAAIEIIRNQKQIANIDRITKYMSRVHGMHPKETTRQLSLAVKDGLIVETLTVGCKGSKAGIEQEGYWLPGDEIDWETENHDWYCFECHLPGEVLICDLCFRVYHSKCLSDEFRLRDSSSPWQCPVCRSIKKKNTNKQEMGTYLRFIVSRMKERAIDLNKKGKDNKHPMYRRLVHSAVDVPTIQEKVNEGKYRSYEEFKADAQLLLHNTVIFYGADSEQADIARMLYKDTCHELDELQLCKNCFYLSNARPDNWFCYPCIPNHELVWAKMKGFGFWPAKVMQKEDNQVDVRFFGHHHQRAWIPSENIQDITVNIHRLHVKRSMGWKKACDELELHQRFLREGRFWKSKNEDRGEEEAESSISSTSNEQLKVTQEPRAKKGRRNQSVEPKKEEPEPETEAVSSSQEIPTMPQPIEKVSVSTQTKKLSASSPRMLHRSTQTTNDGVCQSMCHDKYTKIFNDFKDRMKSDHKRETERVVREALEKLRSEMEEEKRQAVNKAVANMQGEMDRKCKQVKEKCKEEFVEEIKKLATQHKQLISQTKKKQWCYNCEEEAMYHCCWNTSYCSIKCQQEHWHAEHKRTCRRKR 3AD525B90574BDE8 sh3r1_mouse E3 ubiquitin-protein ligase SH3RF1 Posh1 Sh3rf1 Kiaa1494 Posh SH3 domain-containing RING finger protein 1 Plenty of SH3s SH3 multiple domains protein 2 Sh3md2 RING-type E3 ubiquitin transferase SH3RF1 protein protein mouse Mus musculus Mouse MDESALLDLLECPVCLERLDASAKVLPCQHTFCKRCLLGIVGSRNELRCPECRTLVGSGVDELPSNILLVRLLDGIKQRPWKPGPGGGGGTTCTNTLRAQGSTVVNCGSKDLQSSQCGQQPRVQAWSPPVRGIPQLPCAKALYNYEGKEPGDLKFSKGDIIILRRQVDENWYHGEVSGVHGFFPTNFVQIIKPLPQPPPQCKALYDFEVKDKEADKDCLPFAKDDVLTVIRRVDENWAEGMLADKIGIFPISYVEFNSAAKQLIEWDKPPVPGVDTAECPSATAQSTSASKHPDTKKNTRKRHSFTSLTMANKSSQGSQNRHSMEISPPVLISSSNPTAAARISELSGLSCSAPSQVHISTTGLIVTPPPSSPVTTGPAFTFPSDVPYQAALGSMNPPLPPPPLLAATVLASTPSGATAAVAAAAAAAAAAGMGPRPVMGSSEQIAHLRPQTRPSVYVAIYPYTPRKEDELELRKGEMFLVFERCQDGWYKGTSMHTSKIGVFPGNYVAPVTRAVTNASQAKVSMSTAGQASRGVTMVSPSTAGGPTQKPQGNGVAGNPSVVPTAVVSAAHIQTSPQAKVLLHMSGQMTVNQARNAVRTVAAHSQERPTAAVTPIQVQNAACLGPASVGLPHHSLASQPLPPMAGPAAHGAAVSISRTNAPMACAAGASLASPNMTSAMLETEPSGRTVTILPGLPTSPESAASACGNSSAGKPDKDSKKEKKGLLKLLSGASTKRKPRVSPPASPTLDVELGAGEAPLQGAVGPELPLGGSHGRVGSCPTDGDGPVAAGTAALAQDAFHRKTSSLDSAVPIAPPPRQACSSLGPVMNEARPVVCERHRVVVSYPPQSEAELELKEGDIVFVHKKREDGWFKGTLQRNGKTGLFPGSFVENI D92071116F4D6EBE cog1_human Conserved oligomeric Golgi complex subunit 1 COG1 KIAA1381 Component of oligomeric Golgi complex 1 LDLB protein protein human Homo sapiens Human MATAATSPALKRLDLRDPAALFETHGAEEIRGLERQVRAEIEHKKEELRQMVGERYRDLIEAADTIGQMRRCAVGLVDAVKATDQYCARLRQAGSAAPRPPRAQQPQQPSQEKFYSMAAQIKLLLEIPEKIWSSMEASQCLHATQLYLLCCHLHSLLQLDSSSSRYSPVLSRFPILIRQVAAASHFRSTILHESKMLLKCQGVSDQAVAEALCSIMLLEESSPRQALTDFLLARKATIQKLLNQPHHGAGIKAQICSLVELLATTLKQAHALFYTLPEGLLPDPALPCGLLFSTLETITGQHPAGKGTGVLQEEMKLCSWFKHLPASIVEFQPTLRTLAHPISQEYLKDTLQKWIHMCNEDIKNGITNLLMYVKSMKGLAGIRDAMWELLTNESTNHSWDVLCRRLLEKPLLFWEDMMQQLFLDRLQTLTKEGFDSISSSSKELLVSALQELESSTSNSPSNKHIHFEYNMSLFLWSESPNDLPSDAAWVSVANRGQFASSGLSMKAQAISPCVQNFCSALDSKLKVKLDDLLAYLPSDDSSLPKDVSPTQAKSSAFDRYADAGTVQEMLRTQSVACIKHIVDCIRAELQSIEEGVQGQQDALNSAKLHSVLFMARLCQSLGELCPHLKQCILGKSESSEKPAREFRALRKQGKVKTQEIIPTQAKWQEVKEVLLQQSVMGYQVWSSAVVKVLIHGFTQSLLLDDAGSVLATATSWDELEIQEEAESGSSVTSKIRLPAQPSWYVQSFLFSLCQEINRVGGHALPKVTLQEMLKSCMVQVVAAYEKLSEEKQIKKEGAFPVTQNRALQLLYDLRYLNIVLTAKGDEVKSGRSKPDSRIEKVTDHLEALIDPFDLDVFTPHLNSNLHRLVQRTSVLFGLVTGTENQLAPRSSTFNSQEPHNILPLASSQIRFGLLPLSMTSTRKAKSTRNIETKAQVVPPARSTAGDPTVPGSLFRQLVSEEDNTSAPSLFKLGWLSSMTK 68C066504260E36E p60953-1 Cell division control protein 42 homolog CDC42 G25K GTP-binding protein Brain protein protein human Homo sapiens Human MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQRGLKNVFDEAILAALEPPETQPKRKCCIF DIP protein P60953-1 original sequence version: 135 34B44F9225EC106B fhod1_human FH1/FH2 domain-containing protein 1 FHOD1 FHOS FHOS1 Formin homolog overexpressed in spleen 1 Formin homology 2 domain-containing protein 1 protein protein human Homo sapiens Human MAGGEDRGDGEPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCALQVSPSGYYLDTELSLEEQREMLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYSSSGPELRRSLFSLKQIFQEDKDLVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSDTIQWLYTLCASLSRLVVKTALKLLLVFVEYSENNAPLFIRAVNSVASTTGAPPWANLVSILEEKNGADPELLVYTVTLINKTLAALPDQDSFYDVTDALEQQGMEALVQRHLGTAGTDVDLRTQLVLYENALKLEDGDIEEAPGAGGRRERRKPSSEEGKRSRRSLEGGGCPARAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDMLNVESVEAGKDIPAPSPPLPLLSGVPPPPPLPPPPPIKGPFPPPPPLPLAAPLPHSVPDSSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSVDTARLEHLFESRAKEVLPSKKAGEGRRTMTTVLDPKRSNAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQSSGFELSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQAAREVRIMQFCHTLREFALEYRTCRERVLQQQQKQATYRERNKTRGRMITETEKFSGVAGEAPSNPSVPVAVSSGPGRGDADSHASMKSLLTSRPEDTTHNRRSRGMVQSSSPIMPTVGPSTASPEEPPGSSLPSDTSDEIMDLLVQSVTKSSPRALAARERKRSRGNRKSLRRTLKSGLGDDLVQALGLSKGPGLEV DIP protein Q9Y613 original sequence version: 71 DIP protein Q9Y613 original sequence version: 128 E6C7AE1FB8DC3FC7 apc_human Adenomatous polyposis coli protein APC DP2.5 Deleted in polyposis 2.5 protein protein human Homo sapiens Human MAAASYDQLLKQVEALKMENSNLRQELEDNSNHLTKLETEASNMKEVLKQLQGSIEDEAMASSGQIDLLERLKELNLDSSNFPGVKLRSKMSLRSYGSREGSVSSRSGECSPVPMGSFPRRGFVNGSRESTGYLEELEKERSLLLADLDKEEKEKDWYYAQLQNLTKRIDSLPLTENFSLQTDMTRRQLEYEARQIRVAMEEQLGTCQDMEKRAQRRIARIQQIEKDILRIRQLLQSQATEAERSSQNKHETGSHDAERQNEGQGVGEINMATSGNGQGSTTRMDHETASVLSSSSTHSAPRRLTSHLGTKVEMVYSLLSMLGTHDKDDMSRTLLAMSSSQDSCISMRQSGCLPLLIQLLHGNDKDSVLLGNSRGSKEARARASAALHNIIHSQPDDKRGRREIRVLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCVLMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDANIMSPGSSLPSLHVRKQKALEAELDAQHLSETFDNIDNLSPKASHRSKQRHKQSLYGDYVFDTNRHDDNRSDNFNTGNMTVLSPYLNTTVLPSSSSSRGSLDSSRSEKDRSLERERGIGLGNYHPATENPGTSSKRGLQISTTAAQIAKVMEEVSAIHTSQEDRSSGSTTELHCVTDERNALRRSSAAHTHSNTYNFTKSENSNRTCSMPYAKLEYKRSSNDSLNSVSSSDGYGKRGQMKPSIESYSEDDESKFCSYGQYPADLAHKIHSANHMDDNDGELDTPINYSLKYSDEQLNSGRQSPSQNERWARPKHIIEDEIKQSEQRQSRNQSTTYPVYTESTDDKHLKFQPHFGQQECVSPYRSRGANGSETNRVGSNHGINQNVSQSLCQEDDYEDDKPTNYSERYSEEEQHEEEERPTNYSIKYNEEKRHVDQPIDYSLKYATDIPSSQKQSFSFSKSSSGQSSKTEHMSSSSENTSTPSSNAKRQNQLHPSSAQSRSGQPQKAATCKVSSINQETIQTYCVEDTPICFSRCSSLSSLSSAEDEIGCNQTTQEADSANTLQIAEIKEKIGTRSAEDPVSEVPAVSQHPRTKSSRLQGSSLSSESARHKAVEFSSGAKSPSKSGAQTPKSPPEHYVQETPLMFSRCTSVSSLDSFESRSIASSVQSEPCSGMVSGIISPSDLPDSPGQTMPPSRSKTPPPPPQTAQTKREVPKNKAPTAEKRESGPKQAAVNAAVQRVQVLPDADTLLHFATESTPDGFSCSSSLSALSLDEPFIQKDVELRIMPPVQENDNGNETESEQPKESNENQEKEAEKTIDSEKDLLDDSDDDDIEILEECIISAMPTKSSRKAKKPAQTASKLPPPVARKPSQLPVYKLLPSQNRLQPQKHVSFTPGDDMPRVYCVEGTPINFSTATSLSDLTIESPPNELAAGEGVRGGAQSGEFEKRDTIPTEGRSTDEAQGGKTSSVTIPELDDNKAEEGDILAECINSAMPKGKSHKPFRVKKIMDQVQQASASSSAPNKNQLDGKKKKPTSPVKPIPQNTEYRTRVRKNADSKNNLNAERVFSDNKDSKKQNLKNNSKVFNDKLPNNEDRVRGSFAFDSPHHYTPIEGTPYCFSRNDSLSSLDFDDDDVDLSREKAELRKAKENKESEAKVTSHTELTSNQQSANKTQAIAKQPINRGQPKPILQKQSTFPQSSKDIPDRGAATDEKLQNFAIENTPVCFSHNSSLSSLSDIDQENNNKENEPIKETEPPDSQGEPSKPQASGYAPKSFHVEDTPVCFSRNSSLSSLSIDSEDDLLQECISSAMPKKKKPSRLKGDNEKHSPRNMGGILGEDLTLDLKDIQRPDSEHGLSPDSENFDWKAIQEGANSIVSSLHQAAAAACLSRQASSDSDSILSLKSGISLGSPFHLTPDQEEKPFTSNKGPRILKPGEKSTLETKKIESESKGIKGGKKVYKSLITGKVRSNSEISGQMKQPLQANMPSISRGRTMIHIPGVRNSSSSTSPVSKKGPPLKTPASKSPSEGQTATTSPRGAKPSVKSELSPVARQTSQIGGSSKAPSRSGSRDSTPSRPAQQPLSRPIQSPGRNSISPGRNGISPPNKLSQLPRTSSPSTASTKSSGSGKMSYTSPGRQMSQQNLTKQTGLSKNASSIPRSESASKGLNQMNNGNGANKKVELSRMSSTKSSGSESDRSERPVLVRQSTFIKEAPSPTLRRKLEESASFESLSPSSRPASPTRSQAQTPVLSPSLPDMSLSTHSSVQAGGWRKLPPNLSPTIEYNDGRPAKRHDIARSHSESPSRLPINRSGTWKREHSKHSSSLPRVSTWRRTGSSSSILSASSESSEKAKSEDEKHVNSISGTKQSKENQVSAKGTWRKIKENEFSPTNSTSQTVSSGATNGAESKTLIYQMAPAVSKTEDVWVRIEDCPINNPRSGRSPTGNTPPVIDSVSEKANPNIKDSKDNQAKQNVGNGSVPMRTVGLENRLNSFIQVDAPDQKGTEIKPGQNNPVPVSETNESSIVERTPFSSSSSSKHSSPSGTVAARVTPFNYNPSPRKSSADSTSARPSQIPTPVNNNTKKRDSKTDSTESSGTQSPKRHSGSYLVTSV DIP protein P25054 original sequence version: 143 DIP protein P25054-1 original sequence version: 157 DIP protein P25054 original sequence version: 158 77E194AE4A91DC5A prs6b_human 26S proteasome regulatory subunit 6B Proteasome 26S subunit ATPase 4 MB67-interacting protein PSMC4 TBP7 MIP224 Tat-binding protein 7 26S proteasome AAA-ATPase subunit RPT3 protein protein human Homo sapiens Human MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK DIP protein P43686 original sequence version: 63 80F9523C61B88F0C arhg3_human Rho guanine nucleotide exchange factor 3 ARHGEF3 Exchange factor found in platelets and leukemic and neuronal tissues protein protein human Homo sapiens Human MVAKDYPFYLTVKRANCSLELPPASGPAKDAEEPSNKRVKPLSRVTSLANLIPPVKATPLKRFSQTLQRSISFRSESRPDILAPRPWSRNAAPSSTKRRDSKLWSETFDVCVNQMLTSKEIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEELLSQLRDVRKPDGSTEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKKQDHRVQDFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQGIVAEINTKTGESECRYYKERLLYLEEGQKDSLIDSSRVLCCHGELKNNRGVKLHVFLFQEVLVITRAVTHNEQLCYQLYRQPIPVKDLLLEDLQDGEVRLGGSLRGAFSNNERIKNFFRVSFKNGSQSQTHSLQANDTFNKQQWLNCIRQAKETVLCAAGQAGVLDSEGSFLNPTTGSRELQGETKLEQMDQSDSESDCSMDTSEVSLDCERMEQTDSSCGNSRHGESNV 0FE8248AB52D1CBC mcm7_human DNA replication licensing factor MCM7 MCM7 CDC47 MCM2 CDC47 homolog P1.1-MCM3 protein protein human Homo sapiens Human MALKDYALEKEKVKKFLQEFYQDDELGKKQFKYGNQLVRLAHREQVALYVDLDDVAEDDPELVDSICENARRYAKLFADAVQELLPQYKEREVVNKDVLDVYIEHRLMMEQRSRDPGMVRSPQNQYPAELMRRFELYFQGPSSNKPRVIREVRADSVGKLVTVRGIVTRVSEVKPKMVVATYTCDQCGAETYQPIQSPTFMPLIMCPSQECQTNRSGGRLYLQTRGSRFIKFQEMKMQEHSDQVPVGNIPRSITVLVEGENTRIAQPGDHVSVTGIFLPILRTGFRQVVQGLLSETYLEAHRIVKMNKSEDDESGAGELTREELRQIAEEDFYEKLAASIAPEIYGHEDVKKALLLLLVGGVDQSPRGMKIRGNINICLMGDPGVAKSQLLSYIDRLAPRSQYTTGRGSSGVGLTAAVLRDSVSGELTLEGGALVLADQGVCCIDEFDKMAEADRTAIHEVMEQQTISIAKAGILTTLNARCSILAAANPAYGRYNPRRSLEQNIQLPAALLSRFDLLWLIQDRPDRDNDLRLAQHITYVHQHSRQPPSQFEPLDMKLMRRYIAMCREKQPMVPESLADYITAAYVEMRREAWASKDATYTSARTLLAILRLSTALARLRMVDVVEKEDVNEAIRLMEMSKDSLLGDKGQTARTQRPADVIFATVRELVSGGRSVRFSEAEQRCVSRGFTPAQFQAALDEYEELNVWQVNASRTRITFV DIP protein P33993 original sequence version: 161 DIP protein P33993 original sequence version: 124 330A1DEFAEFBFB88 prkra_human Interferon-inducible double-stranded RNA-dependent protein kinase activator A Protein activator of the interferon-induced protein kinase PKR-associated protein X PKR-associating protein X HSD-14 PRKRA RAX PACT HSD14 Protein kinase, interferon-inducible double-stranded RNA-dependent activator protein protein human Homo sapiens Human MSQSRHRAEAPPLEREDSGTFSLGKMITAKPGKTPIQVLHEYGMKTKNIPVYECERSDVQIHVPTFTFRVTVGDITCTGEGTSKKLAKHRAAEAAINILKANASICFAVPDPLMPDPSKQPKNQLNPIGSLQELAIHHGWRLPEYTLSQEGGPAHKREYTTICRLESFMETGKGASKKQAKRNAAEKFLAKFSNISPENHISLTNVVGHSLGCTWHSLRNSPGEKINLLKRSLLSIPNTDYIQLLSEIAKEQGFNITYLDIDELSANGQYQCLAELSTSPITVCHGSGISCGNAQSDAAHNALQYLKIIAERK 9B01637E6194827E usf2_human Upstream stimulatory factor 2 USF2 Upstream transcription factor 2 FOS-interacting protein Major late transcription factor 2 BHLHB12 Class B basic helix-loop-helix protein 12 protein protein human Homo sapiens Human MDMLDPGLDPAASATAAAAASHDKGPEAEEGVELQEGGDGPGAEEQTAVAITSVQQAAFGDHNIQYQFRTETNGGQVTYRVVQVTDGQLDGQGDTAGAVSVVSTAAFAGGQQAVTQVGVDGAAQRPGPAAASVPPGPAAPFPLAVIQNPFSNGGSPAAEAVSGEARFAYFPASSVGDTTAVSVQTTDQSLQAGGQFYVMMTPQDVLQTGTQRTIAPRTHPYSPKIDGTRTPRDERRRAQHNEVERRRRDKINNWIVQLSKIIPDCNADNSKTGASKGGILSKACDYIRELRQTNQRMQETFKEAERLQMDNELLRQQIEELKNENALLRAQLQQHNLEMVGEGTRQ 78CEFE97AC4C10CF baip2_human Brain-specific angiogenesis inhibitor 1-associated protein 2 Insulin receptor substrate protein of 53 kDa Insulin receptor substrate p53/p58 Fas ligand-associated factor 3 BAIAP2 protein protein human Homo sapiens Human MSLSRSEEMHRLTENVYKTIMEQFNPSLRNFIAMGKNYEKALAGVTYAAKGYFDALVKMGELASESQGSKELGDVLFQMAEVHRQIQNQLEEMLKSFHNELLTQLEQKVELDSRYLSAALKKYQTEQRSKGDALDKCQAELKKLRKKSQGSKNPQKYSDKELQYIDAISNKQGELENYVSDGYKTALTEERRRFCFLVEKQCAVAKNSAAYHSKGKELLAQKLPLWQQACADPSKIPERAVQLMQQVASNGATLPSALSASKSNLVISDPIPGAKPLPVPPELAPFVGRMSAQESTPIMNGVTGPDGEDYSPWADRKAAQPKSLSPPQSQSKLSDSYSNTLPVRKSVTPKNSYATTENKTLPRSSSMAAGLERNGRMRVKAIFSHAAGDNSTLLSFKEGDLITLLVPEARDGWHYGESEKTKMRGWFPFSYTRVLDSDGSDRLHMSLQQGKSSSTGNLLDKDDLAIPPPDYGAASRAFPAQTASGFKQRPYSVAVPAFSQGLDDYGARSMSRNPFAHVQLKPTVTNDRCDLSAQGPEGREHGDGSARTLAGR DIP protein Q9UQB8 original sequence version: 87 3B9EDC6405DCC99D ack1_human Activated CDC42 kinase 1 ACK1 TNK2 Tyrosine kinase non-receptor protein 2 protein protein human Homo sapiens Human MQPEEGTGWLLELLSEVQLQQYFLRLRDDLNVTRLSHFEYVKNEDLEKIGMGRPGQRRLWEAVKRRKALCKRKSWMSKVFSGKRLEAEFPPHHSQSTFRKTSPAPGGPAGEGPLQSLTCLIGEKDLRLLEKLGDGSFGVVRRGEWDAPSGKTVSVAVKCLKPDVLSQPEAMDDFIREVNAMHSLDHRNLIRLYGVVLTPPMKMVTELAPLGSLLDRLRKHQGHFLLGTLSRYAVQVAEGMGYLESKRFIHRDLAARNLLLATRDLVKIGDFGLMRALPQNDDHYVMQEHRKVPFAWCAPESLKTRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPRPEDCPQDIYNVMVQCWAHKPEDRPTFVALRDFLLEAQPTDMRALQDFEEPDKLHIQMNDVITVIEGRAENYWWRGQNTRTLCVGPFPRNVVTSVAGLSAQDISQPLQNSFIHTGHGDSDPRHCWGFPDRIDELYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPLSSDFKRLGLRKPGLPRGLWLAKPSARVPGTKASRGSGAEVTLIDFGEEPVVPALRPCAPSLAQLAMDACSLLDETPPQSPTRALPRPLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEICSINSTLVGAGVPAGPSQGQTNYAFVPEQARPPPPLEDNLFLPPQGGGKPPSSAQTAEIFQALQQECMRQLQAPAGSPAPSPSPGGDDKPQVPPRVPIPPRPTRPHVQLSPAPPGEEETSQWPGPASPPRVPPREPLSPQGSRTPSPLVPPGSSPLPPRLSSSPGKTMPTTQSFASDPKYATPQVIQAPGPRAGPCILPIVRDGKKVSSTHYYLLPERPSYLERYQRFLREAQSPEEPTPLPVPLLLPPPSTPAPAAPTATVRPMPQAALDPKANFSTNNSNPGARPPPPRATARLPQRGCPGDGPEAGRPADKIQMAMVHGVTTEECQAALQCHGWSVQRAAQYLKVEQLFGLGLRPRGECHKVLEMFDWNLEQAGCHLLGSWGPAHHKR DIP protein Q07912 original sequence version: 150 DIP protein Q07912 original sequence version: 117 74A1980665BC3E6B ranb9_human Ran-binding protein 9 RanBP7 Ran-binding protein M BPM90 BPM-L RANBP9 RANBPM protein protein human Homo sapiens Human MSGQPPPPPPQQQQQQQQLSPPPPAALAPVSGVVLPAPPAVSAGSSPAGSPGGGAGGEGLGAAAAALLLHPPPPPPPATAAPPPPPPPPPPPASAAAPASGPPAPPGLAAGPGPAGGAPTPALVAGSSAAAPFPHGDSALNEQEKELQRRLKRLYPAVDEQETPLPRSWSPKDKFSYIGLSQNNLRVHYKGHGKTPKDAASVRATHPIPAACGIYYFEVKIVSKGRDGYMGIGLSAQGVNMNRLPGWDKHSYGYHGDDGHSFCSSGTGQPYGPTFTTGDVIGCCVNLINNTCFYTKNGHSLGIAFTDLPPNLYPTVGLQTPGEVVDANFGQHPFVFDIEDYMREWRTKIQAQIDRFPIGDREGEWQTMIQKMVSSYLVHHGYCATAEAFARSTDQTVLEELASIKNRQRIQKLVLAGRMGEAIETTQQLYPSLLERNPNLLFTLKVRQFIEMVNGTDSEVRCLGGRSPKSQDSYPVSPRPFSSPSMSPSHGMNIHNLASGKGSTAHFSGFESCSNGVISNKAHQSYCHSNKHQSSNLNVPELNSINMSRSQQVNNFTSNDVDMETDHYSNGVGETSSNGFLNGSSKHDHEMEDCDTEMEVDSSQLRRQLCGGSQAAIERMIHFGRELQAMSEQLRRDCGKNTANKKMLKDAFSLLAYSDPWNSPVGNQLDPIQREPVCSALNSAILETHNLPKQPPLALAMGQATQCLGLMARSGIGSCAFATVEDYLH 50DF1127B7FDA6C8 cdc42_human Cell division control protein 42 homolog CDC42 G25K GTP-binding protein protein protein human Homo sapiens Human MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGQEDYDRLRPLSYPQTDVFLVCFSVVSPSSFENVKEKWVPEITHHCPKTPFLLVGTQIDLRDDPSTIEKLAKNKQKPITPETAEKLARDLKAVKYVECSALTQKGLKNVFDEAILAALEPPEPKKSRRCVLL 51A437E22A4D8FFF wasl_human Neural Wiskott-Aldrich syndrome protein WASL protein protein human Homo sapiens Human MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDEEDFEDDDEWED DIP protein O00401 original sequence version: 55 DIP protein O00401 original sequence version: 147 DIP protein O00401 original sequence version: 150 DIP protein O00401 original sequence version: 136 DIP protein O00401 original sequence version: 138 DIP protein O00401 original sequence version: 125 DIP protein O00401 original sequence version: 112 DIP protein O00401 original sequence version: 126 B5895C6055E23049 pak2_mouse Serine/threonine-protein kinase PAK 2 p21-activated kinase 2 Gamma-PAK Pak2 protein protein mouse Mus musculus Mouse MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRNKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNTKGSETSAVVTEEDDDDEDAAPPVIAPRPDHTKSIYTRSVIDPIPAPVGDSNVDSGAKSSDKQKKKAKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLILAAKEAMKSNR DIP protein Q8CIN4 original sequence version: 83 D8BDA7B193D41B1B pcgf6_human Polycomb group RING finger protein 6 RING finger protein 134 Mel18 and Bmi1-like RING finger PCGF6 MBLR RNF134 protein protein human Homo sapiens Human MEGVAVVTAGSVGAAKTEGAAALPPPPPVSPPALTPAPAAGEEGPAPLSETGAPGCSGSRPPELEPERSLGRFRGRFEDEDEELEEEEELEEEEEEEEEDMSHFSLRLEGGRQDSEDEEERLINLSELTPYILCSICKGYLIDATTITECLHTFCKSCIVRHFYYSNRCPKCNIVVHQTQPLYNIRLDRQLQDIVYKLVINLEEREKKQMHDFYKERGLEVPKPAVPQPVPSSKGRSKKVLESVFRIPPELDMSLLLEFIGANEGTGHFKPLEKKFVRVSGEATIGHVEKFLRRKMGLDPACQVDIICGDHLLEQYQTLREIRRAIGDAAMQDGLLVLHYGLVVSPLKIT DIP protein Q9BYE7 original sequence version: 81 DIP protein Q9BYE7 original sequence version: 123 05977FE6F14972DE rac1_human Ras-related C3 botulinum toxin substrate 1 RAC1 MIG5 p21-Rac1 Ras-like protein TC25 Cell migration-inducing gene 5 protein TC25 protein protein human Homo sapiens Human MQAIKCVVVGDGAVGKTCLLISYTTNAFPGEYIPTVFDNYSANVMVDGKPVNLGLWDTAGQEDYDRLRPLSYPQTDVFLICFSLVSPASFENVRAKWYPEVRHHCPNTPIILVGTKLDLRDDKDTIEKLKEKKLTPITYPQGLAMAKEIGAVKYLECSALTQRGLKTVFDEAIRAVLCPPPVKKRKRKCLLL ACEDF83A45E5EA67 arh40_mouse Rho guanine nucleotide exchange factor 40 Arhgef40 Solo Protein SOLO protein protein mouse Mus musculus Mouse MEPEPVEDCVQSTLAALYPPFEATAPTLLGQVFQVVERTYQEDALRYTLDFLVPAKHLLAKVQQEACAQYSGFLFFHEGWPLCLHEQVVVQLAALPWQLLRPGDFYLQVVPSAAQAPRLALKCLAPGGGRVQELPVPSEACAYLFTPEWLQGINKDRPTGRLSTCLLSAPSGIQRLPWAELVCPRFVHKEGLMVGHQPSTLPPELPSGPPGLPSSPLPEEVLGTRSPGDGHNAPAEGPEGEYVELLEVTLPVRGSPVDAEASGLSRTRTVPARKSTGGKGRHRRHRAWMNQKGLGSRDQDGTRPPGEGSSTGASSDSPSGAEADPDATALQASEPPAEALGEAPESCLLSGEAVGGVGQGAEGPPGTPRRTGKGNRRKKRAAGRGAGSRGGEGTSLSPRDKEETRQQEVLVSLPSPSEQEPAECSLVKEKEDSGKQESESKEELKPADEKEPARPEDYEPPEEEIRESEKEELTPQCTAGSTGPEWFPSEPSTQPLETVQNVKGDSLPEETPPVSVLDDPVVAWDLMASGFFVLTGGVDQTGRALLTITPPPPCLPEESSPSQETLSTALRYLHSLLRPDLQLLGLTILLDLRKAPPLPPALLPALSQLQDSGEPPLIQRLVILIHEDPPAELCGFQGAELLSEKDLKRVAKPEELQWDLGGHRDLSPNHWAEIHQEVARLCTLCQGVLTSVRQAIEELEGTAEPKEEEAVGMPEPLQKVLADPRLTALQRNGGAILMRLRSAHSSKLEGPGPAELYQEVDEAIHQLVRLSNLRVQQQEERQRLRQVQQVLQWLSGPGEEQLASFSMPGNSLSVLQETELRFRAFSTEVQERLVQAREALALEEDLTSQKVLDIFEQRLEQAESGLHRALRLQRFFQQAHEWVDEGSARLAGAGSGREALLAALALRRAPEPSAGTFQEMRALALDLGSPAALREWGRCRARCQELERRIQQQLGEEASPRSHRRRRADSASSAGAQHGAHSPSPSLSSLLLPSSPGPRAAPSHCSLTPCGEDYEEEGLELAPETDGRPPRAVLIRGLEVTSTEVVDRTCSPREHVLLGRAGGPDGPWGIGTPRMERKRSISAQQRLVSELIACEQEYVTTLNEPVPLPGPELTPELRCTWAAALSVRERLRSFHGTHFLQELQGCAAHPLRIGACFLRHGDQFNLYAQFVKHRHKLESGLAALTPSVKGSMESSPCLPRALQQPLEQLARYGQLLEELLREAGPELSSERQALRAAVQLLQEQEARGRDLLAVEAVRGCEIDLKEQGQLLHRDPFTVICGRKKCLRHVFLFEDLLLFSKLKGSEGGSETFVYKQAFKTADMGLTENIGDSGLCFELWFRRRRAREAYTLQATSPETKLKWTSSIAQLLWRQAAHNKELRVQQMVSMGIGNKPFLDIKALGERTLSALLTGRAARTRASVAVSSFEHAGPSLPGLSPGACSLPARVEEEAWDLDVKQISLASETLDSSGDVSPGPRNSPSLQPPSPGSSTPALTSGGILGLSRQSHSRALSDPTTPL 63A0F5900AC42D2E myo9a_human Unconventional myosin-IXa MYO9A MYR7 Unconventional myosin-9a protein protein human Homo sapiens Human MNINDGGRRRFEDNEHTLRIYPGAISEGTIYCPIPARKNSTAAEVIESLINKLHLDKTKCYVLAEVKEFGGEEWILNPTDCPVQRMMLWPRMALENRLSGEDYRFLLREKNLDGSIHYGSLQSWLRVTEERRRMMERGFLPQPQQKDFDDLCSLPDLNEKTLLENLRNRFKHEKIYTYVGSILIVINPFKFLPIYNPKYVKMYDNHQLGKLEPHIYAVADVAYHAMLQRKKNQCIVISGESGSGKTQSTNFLIHHLTALSQKGFASGVEQIILGAGPVLEAFGNAKTAHNNNSSRFGKFIQVNYQETGTVLGAYVEKYLLEKSRLVYQEHNERNYHVFYYLLAGASEDERSAFHLKQPEEYHYLNQITKKPLRQSWDDYCYDSEPDCFTVEGEDLRHDFERLQLAMEMVGFLPKTRRQIFSLLSAILHLGNICYKKKTYRDDSIDICNPEVLPIVSELLEVKEEMLFEALVTRKTVTVGEKLILPYKLAEAVTVRNSMAKSLYSALFDWIVFRINHALLNSKDLEHNTKTLSIGVLDIFGFEDYENNSFEQFCINFANERLQHYFNQHIFKLEQEEYRTEGISWHNIDYIDNTCCINLISKKPTGLLHLLDEESNFPQATNQTLLDKFKHQHEDNSYIEFPAVMEPAFIIKHYAGKVKYGVKDFREKNTDHMRPDIVALLRSSKNAFISGMIGIDPVAVFRWAILRAFFRAMVAFREAGKRNIHRKTGHDDTAPCAILKSMDSFSFLQHPVHQRSLEILQRCKEEKYSITRKNPRTPLSDLQGMNALNEKNQHDTFDIAWNGRTGIRQSRLSSGTSLLDKDGIFANSTSSKLLERAHGILTRNKNFKSKPALPKHLLEVNSLKHLTRLTLQDRITKSLLHLHKKKKPPSISAQFQASLSKLMETLGQAEPYFVKCIRSNAEKLPLRFSDVLVLRQLRYTGMLETVRIRQSGYSSKYSFQDFVSHFHVLLPRNIIPSKFNIQDFFRKINLNPDNYQVGKTMVFLKEQERQHLQDLLHQEVLRRIILLQRWFRVLLCRQHFLHLRQASVIIQRFWRNYLNQKQVRDAAVQKDAFVMASAAALLQASWRAHLERQRYLELRAAAIVIQQKWRDYYRRRHMAAICIQARWKAYRESKRYQEQRKKIILLQSTCRGFRARQRFKALKEQRLRETKPEVGLVNIKGYGSLEIQGSDPSGWEDCSFDNRIKAIEECKSVIESNRISRESSVDCLKESPNKQQERAQSQSGVDLQEDVLVRERPRSLEDLHQKKVGRAKRESRRMRELEQAIFSLELLKVRSLGGISPSEDRRWSTELVPEGLQSPRGTPDSESSQGSLELLSYEESQKSKLESVISDEGDLQFPSPKISSSPKFDSRDNALSASNETSSAEHLKDGTMKEMVVCSSESITCKPQLKDSFISNSLPTFFYIPQQDPLKTNSQLDTSIQRNKLLENEDTAGEALTLDINRETRRYHCSGKDQIVPSLNTESSNPVLKKLEKLNTEKEERQKQLQQQNEKEMMEQIRQQTDILEKERKAFKTIEKPRIGECLVAPSSYQSKQRVERPSSLLSLNTSNKGELNVLGSLSLKDAALAQKDSSSAHLPPKDRPVTVFFERKGSPCQSSTVKELSKTDRMGTQLNVACKLSNNRISKREHFRPTQSYSHNSDDLSREGNARPIFFTPKDNMSIPLVSKEALNSKNPQLHKEDEPAWKPVKLAGPGQRETSQRFSSVDEQAKLHKTMSQGEITKLAVRQKASDSDIRPQRAKMRFWAKGKQGEKKTTRVKPTTQSEVSPLFAGTDVIPAHQFPDELAAYHPTPPLSPELPGSCRKEFKENKEPSPKAKRKRSVKISNVALDSMHWQNDSVQIIASVSDLKSMDEFLLKKVNDLDNEDSKKDTLVDVVFKKALKEFRQNIFSFYSSALAMDDGKSIRYKDLYALFEQILEKTMRLEQRDSLGESPVRVWVNTFKVFLDEYMNEFKTSDCTATKVPKTERKKRRKKETDLVEEHNGHIFKATQYSIPTYCEYCSSLIWIMDRASVCKLCKYACHKKCCLKTTAKCSKKYDPELSSRQFGVELSRLTSEDRTVPLVVEKLINYIEMHGLYTEGIYRKSGSTNKIKELRQGLDTDAESVNLDDYNIHVIASVFKQWLRDLPNPLMTFELYEEFLRAMGLQERKETIRGVYSVIDQLSRTHLNTLERLIFHLVRIALQEDTNRMSANALAIVFAPCILRCPDTTDPLQSVQDISKTTTCVELIVVEQMNKYKARLKDISSLEFAENKAKTRLSLIRRSMGKGRIRRGNYPGPSSPVVVRLPSVSDVSEETLTSEAAMETDITEQQQAAMQQEERVLTEQIENLQKEKEELTFEMLVLEPRASDDETLESEASIGTADSSENLNMESEYAISEKSERSLALSSLKTAGKSEPSSKLRKQLKKQQDSLDVVDSSVSSLCLSNTASSHGTRKLFQIYSKSPFYRAASGNEALGMEGPLGQTKFLEDKPQFISRGTFNPEKGKQKLKNVKNSPQKTKETPEGTVMSGRRKTVDPDCTSNQQLALFGNNEFMV 867835BD2B841C84 tbcd4_human TBC1 domain family member 4 Akt substrate of 160 kDa TBC1D4 KIAA0603 AS160 protein protein human Homo sapiens Human MEPPSCIQDEPFPHPLEPEPGVSAQPGPGKPSDKRFRLWYVGGSCLDHRTTLPMLPWLMAEIRRRSQKPEAGGCGAPAAREVILVLSAPFLRCVPAPGAGASGGTSPSATQPNPAVFIFEHKAQHISRFIHNSHDLTYFAYLIKAQPDDPESQMACHVFRATDPSQVPDVISSIRQLSKAAMKEDAKPSKDNEDAFYNSQKFEVLYCGKVTVTHKKAPSSLIDDCMEKFSLHEQQRLKIQGEQRGPDPGEDLADLEVVVPGSPGDCLPEEADGTDTHLGLPAGASQPALTSSRVCFPERILEDSGFDEQQEFRSRCSSVTGVQRRVHEGSQKSQPRRRHASAPSHVQPSDSEKNRTMLFQVGRFEINLISPDTKSVVLEKNFKDISSCSQGIKHVDHFGFICRESPEPGLSQYICYVFQCASESLVDEVMLTLKQAFSTAAALQSAKTQIKLCEACPMHSLHKLCERIEGLYPPRAKLVIQRHLSSLTDNEQADIFERVQKMKPVSDQEENELVILHLRQLCEAKQKTHVHIGEGPSTISNSTIPENATSSGRFKLDILKNKAKRSLTSSLENIFSRGANRMRGRLGSVDSFERSNSLASEKDYSPGDSPPGTPPASPPSSAWQTFPEEDSDSPQFRRRAHTFSHPPSSTKRKLNLQDGRAQGVRSPLLRQSSSEQCSNLSSVRRMYKESNSSSSLPSLHTSFSAPSFTAPSFLKSFYQNSGRLSPQYENEIRQDTASESSDGEGRKRTSSTCSNESLSVGGTSVTPRRISWRQRIFLRVASPMNKSPSAMQQQDGLDRNELLPLSPLSPTMEEEPLVVFLSGEDDPEKIEERKKSKELRSLWRKAIHQQILLLRMEKENQKLEASRDELQSRKVKLDYEEVGACQKEVLITWDKKLLNCRAKIRCDMEDIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHAILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEEQAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAAPWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLKNTLPDMNTSEMEKIITQVFEMDISKQLHAYEVEYHVLQDELQESSYSCEDSETLEKLERANSQLKRQNMDLLEKLQVAHTKIQALESNLENLLTRETKMKSLIRTLEQEKMAYQKTVEQLRKLLPADALVNCDLLLRDLNCNPNNKAKIGNKP 8DC70CE887C0B311 htra1_human Serine protease HTRA1 HTRA1 HTRA PRSS11 High-temperature requirement A serine peptidase 1 L56 Serine protease 11 protein protein human Homo sapiens Human MQIPRAALLPLLLLLLAAPASAQLSRAGRSAPLAAGCPDRCEPARCPPQPEHCEGGRARDACGCCEVCGAPEGAACGLQEGPCGEGLQCVVPFGVPASATVRRRAQAGLCVCASSEPVCGSDANTYANLCQLRAASRRSERLHRPPVIVLQRGACGQGQEDPNSLRHKYNFIADVVEKIAPAVVHIELFRKLPFSKREVPVASGSGFIVSEDGLIVTNAHVVTNKHRVKVELKNGATYEAKIKDVDEKADIALIKIDHQGKLPVLLLGRSSELRPGEFVVAIGSPFSLQNTVTTGIVSTTQRGGKELGLRNSDMDYIQTDAIINYGNSGGPLVNLDGEVIGINTLKVTAGISFAIPSDKIKKFLTESHDRQAKGKAITKKKYIGIRMMSLTSSKAKELKDRHRDFPDVISGAYIIEVIPDTPAEAGGLKENDVIISINGQSVVSANDVSDVIKRESTLNMVVRRGNEDIMITVIPEEIDP DIP protein Q92743 original sequence version: 106 DIP protein Q92743 original sequence version: 149 DIP protein Q92743 original sequence version: 119 CA20A99480FB2330 pak2_human Serine/threonine-protein kinase PAK 2 p21-activated kinase 2 Gamma-PAK PAK65 S6/H4 kinase p58 PAK2 protein protein human Homo sapiens Human MSDNGELEDKPPAPPVRMSSTIFSTGGKDPLSANHSLKPLPSVPEEKKPRHKIISIFSGTEKGSKKKEKERPEISPPSDFEHTIHVGFDAVTGEFTGMPEQWARLLQTSNITKLEQKKNPQAVLDVLKFYDSNTVKQKYLSFTPPEKDGFPSGTPALNAKGTEAPAVVTEEEDDDEETAPPVIAPRPDHTKSIYTRSVIDPVPAPVGDSHVDGAAKSLDKQKKKTKMTDEEIMEKLRTIVSIGDPKKKYTRYEKIGQGASGTVFTATDVALGQEVAIKQINLQKQPKKELIINEILVMKELKNPNIVNFLDSYLVGDELFVVMEYLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMEGSVKLTDFGFCAQITPEQSKRSTMVGTPYWMAPEVVTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRALYLIATNGTPELQNPEKLSPIFRDFLNRCLEMDVEKRGSAKELLQHPFLKLAKPLSSLTPLIMAAKEAMKSNR DIP protein Q13177 original sequence version: 166 DIP protein Q13177 original sequence version: 114 00A7CD15F93D4180 par6a_human Partitioning defective 6 homolog alpha PARD6A PAR6A PAR6C Tax interaction protein 40 protein protein human Homo sapiens Human MARPQRTPARSPDSIVEVKSKFDAEFRRFALPRASVSGFQEFSRLLRAVHQIPGLDVLLGYTDAHGDLLPLTNDDSLHRALASGPPPLRLLVQKRAEADSSGLAFASNSLQRRKKGLLLRPVAPLRTRPPLLISLPQDFRQVSSVIDVDLLPETHRRVRLHKHGSDRPLGFYIRDGMSVRVAPQGLERVPGIFISRLVRGGLAESTGLLAVSDEILEVNGIEVAGKTLDQVTDMMVANSHNLIVTVKPANQRNNVVRGASGRLTGPPSAGPGPAEPDSDDDSSDLVIENRQPPSSNGLSQGPPCWDLHPGCRHPGTRSSLPSLDDQEQASSGWGSRIRGDGSGFSL DIP protein Q9NPB6 original sequence version: 130 9241E0EDC3694AD4 cdc23_human Cell division cycle protein 23 homolog CDC23 ANAPC8 Anaphase-promoting complex subunit 8 Cyclosome subunit 8 protein protein human Homo sapiens Human MAASTSMVPVAVTAAVAPVLSINSDFSDLREIKKQLLLIAGLTRERGLLHSSKWSAELAFSLPALPLAELQPPPPITEEDAQDMDAYTLAKAYFDVKEYDRAAHFLHGCNSKKAYFLYMYSRYLSGEKKKDDETVDSLGPLEKGQVKNEALRELRVELSKKHQARELDGFGLYLYGVVLRKLDLVKEAIDVFVEATHVLPLHWGAWLELCNLITDKEMLKFLSLPDTWMKEFFLAHIYTELQLIEEALQKYQNLIDVGFSKSSYIVSQIAVAYHNIRDIDKALSIFNELRKQDPYRIENMDTFSNLLYVRSMKSELSYLAHNLCEIDKYRVETCCVIGNYYSLRSQHEKAALYFQRALKLNPRYLGAWTLMGHEYMEMKNTSAAIQAYRHAIEVNKRDYRAWYGLGQTYEILKMPFYCLYYYRRAHQLRPNDSRMLVALGECYEKLNQLVEAKKCYWRAYAVGDVEKMALVKLAKLHEQLTESEQAAQCYIKYIQDIYSCGEIVEHLEESTAFRYLAQYYFKCKLWDEASTCAQKCCAFNDTREEGKALLRQILQLRNQGETPTTEVPAPFFLPASLSANNTPTRRVSPLNLSSVTP DIP protein Q9UJX2 original sequence version: 103 DIP protein Q9UJX2 original sequence version: 131 DIP protein Q9UJX2 original sequence version: 135 DIP protein Q9UJX2 original sequence version: 145 DIP protein Q9UJX2 original sequence version: 154 358F2B8745DB9D32 pals1_human Protein PALS1 PALS1 MAGUK p55 subfamily member 5 MPP5 Membrane protein, palmitoylated 5 Protein associated with Lin-7 1 protein protein human Homo sapiens Human MTTSHMNGHVTEESDSEVKNVDLASPEEHQKHREMAVDCPGDLGTRMMPIRRSAQLERIRQQQEDMRRRREEEGKKQELDLNSSMRLKKLAQIPPKTGIDNPMFDTEEGIVLESPHYAVKILEIEDLFSSLKHIQHTLVDSQSQEDISLLLQLVQNKDFQNAFKIHNAITVHMNKASPPFPLISNAQDLAQEVQTVLKPVHHKEGQELTALLNTPHIQALLLAHDKVAEQEMQLEPITDERVYESIGQYGGETVKIVRIEKARDIPLGATVRNEMDSVIISRIVKGGAAEKSGLLHEGDEVLEINGIEIRGKDVNEVFDLLSDMHGTLTFVLIPSQQIKPPPAKETVIHVKAHFDYDPSDDPYVPCRELGLSFQKGDILHVISQEDPNWWQAYREGDEDNQPLAGLVPGKSFQQQREAMKQTIEEDKEPEKSGKLWCAKKNKKKRKKVLYNANKNDDYDNEEILTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDYHFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPYIIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHYFDTAIVNSDLDKAYQELLRLINKLDTEPQWVPSTWLR A3B2CB594E0908CA brms1_human Breast cancer metastasis-suppressor 1 BRMS1 protein protein human Homo sapiens Human MPVQPPSKDTEEMEAEGDSAAEMNGEEEESEEERSGSQTESEEESSEMDDEDYERRRSECVSEMLDLEKQFSELKEKLFRERLSQLRLRLEEVGAERAPEYTEPLGGLQRSLKIRIQVAGIYKGFCLDVIRNKYECELQGAKQHLESEKLLLYDTLQGELQERIQRLEEDRQSLDLSSEWWDDKLHARGSSRSWDSLPPSKRKKAPLVSGPYIVYMLQEIDILEDWTAIKKARAAVSPQKRKSDGP 89FB59FB96ECD4DB cenpc_human Centromere protein C CENPC CENPC1 Centromere autoantigen C Centromere protein C 1 ICEN7 Interphase centromere complex protein 7 protein protein human Homo sapiens Human MAASGLDHLKNGYRRRFCRPSRARDINTEQGQNVLEILQDCFEEKSLANDFSTNSTKSVPNSTRKIKDTCIQSPSKECQKSHPKSVPVSSKKKEASLQFVVEPSEATNRSVQAHEVHQKILATDVSSKNTPDSKKISSRNINDHHSEADEEFYLSVGSPSVLLDAKTSVSQNVIPSSAQKRETYTFENSVNMLPSSTEVSVKTKKRLNFDDKVMLKKIEIDNKVSDEEDKTSEGQERKPSGSSQNRIRDSEYEIQRQAKKSFSTLFLETVKRKSESSPIVRHAATAPPHSCPPDDTKLIEDEFIIDESDQSFASRSWITIPRKAGSLKQRTISPAESTALLQGRKSREKHHNILPKTLANDKHSHKPHPVETSQPSDKTVLDTSYALIGETVNNYRSTKYEMYSKNAEKPSRSKRTIKQKQRRKFMAKPAEEQLDVGQSKDENIHTSHITQDEFQRNSDRNMEEHEEMGNDCVSKKQMPPVGSKKSSTRKDKEESKKKRFSSESKNKLVPEEVTSTVTKSRRISRRPSDWWVVKSEESPVYSNSSVRNELPMHHNSSRKSTKKTNQSSKNIRKKTIPLKRQKTATKGNQRVQKFLNAEGSGGIVGHDEISRCSLSEPLESDEADLAKKKNLDCSRSTRSSKNEDNIMTAQNVPLKPQTSGYTCNIPTESNLDSGEHKTSVLEESGPSRLNNNYLMSGKNDVDDEEVHGSSDDSKQSKVIPKNRIHHKLVLPSNTPNVRRTKRTRLKPLEYWRGERIDYQGRPSGGFVISGVLSPDTISSKRKAKENIGKVNKKSNKKRICLDNDERKTNLMVNLGIPLGDPLQPTRVKDPETREIILMDLVRPQDTYQFFVKHGELKVYKTLDTPFFSTGKLILGPQEEKGKQHVGQDILVFYVNFGDLLCTLHETPYILSTGDSFYVPSGNYYNIKNLRNEESVLLFTQIKR 2AA5AF82BA88C809 pkhg4_human Puratrophin-1 Pleckstrin homology domain-containing family G member 4 Purkinje cell atrophy-associated protein 1 PLEKHG4 PRTPHN1 protein protein human Homo sapiens Human MERPLENGDESPDSQGHATDWRFAVCSFRDAWEEEEPASQMHVKDPGPPRPPAGATQDEELQGSPLSRKFQLPPAADESGDAQRGTVESSSVLSEGPGPSGVESLLCPMSSHLSLAQGESDTPGVGLVGDPGPSRAMPSGLSPGALDSDPVGLGDPLSEISKLLEAAPSGSGLPKPADCLLAQDLCWELLASGMATLPGTRDVQGRAVLLLCAHSPAWLQSECSSQELIRLLLYLRSIPRPEVQALGLTVLVDARICAPSSSLFSGLSQLQEAAPGAVYQVLLVGSTLLKEVPSGLQLEQLPSQSLLTHIPTAGLPTSLGGGLPYCHQAWLDFRRRLEALLQNCQAACALLQGAIESVKAVPQPMEPGEVGQLLQQTEVLMQQVLDSPWLAWLQCQGGRELTWLKQEVPEVTLSPDYRTAMDKADELYDRVDGLLHQLTLQSNQRIQALELVQTLEARESGLHQIEVWLQQVGWPALEEAGEPSLDMLLQAQGSFQELYQVAQEQVRQGEKFLQPLTGWEAAELDPPGARFLALRAQLTEFSRALAQRCQRLADAERLFQLFREALTWAEEGQRVLAELEQERPGVVLQQLQLHWTRHPDLPPAHFRKMWALATGLGSEAIRQECRWAWARCQDTWLALDQKLEASLKLPPVGSTASLCVSQVPAAPAHPPLRKAYSFDRNLGQSLSEPACHCHHAATIAACRRPEAGGGALPQASPTVPPPGSSDPRSLNRLQLVLAEMVATEREYVRALEYTMENYFPELDRPDVPQGLRGQRAHLFGNLEKLRDFHCHFFLRELEACTRHPPRVAYAFLRHRVQFGMYALYSKNKPRSDALMSSYGHTFFKDKQQALGDHLDLASYLLKPIQRMGKYALLLQELARACGGPTQELSALREAQSLVHFQLRHGNDLLAMDAIQGCDVNLKEQGQLVRQDEFVVRTGRHKSVRRIFLFEELLLFSKPRHGPTGVDTFAYKRSFKMADLGLTECCGNSNLRFEIWFRRRKARDTFVLQASSLAIKQAWTADISHLLWRQAVHNKEVRMAEMVSMGVGNKAFRDIAPSEEAINDRTVNYVLKCREVRSRASIAVAPFDHDSLYLGASNSLPGDPASCSVLGSLNLHLYRDPALLGLRCPLYPSFPEEAALEAEAELGGQPSLTAEDSEISSQCPSASGSSGSDSSCVSGQALGRGLEDLPCV ACFF5EE342CE56FD flip1_human Filamin-A-interacting protein 1 FILIP1 KIAA1275 protein protein human Homo sapiens Human MRSRNQGGESASDGHISCPKPSIIGNAGEKSLSEDAKKKKKSNRKEDDVMASGTVKRHLKTSGECERKTKKSLELSKEDLIQLLSIMEGELQAREDVIHMLKTEKTKPEVLEAHYGSAEPEKVLRVLHRDAILAQEKSIGEDVYEKPISELDRLEEKQKETYRRMLEQLLLAEKCHRRTVYELENEKHKHTDYMNKSDDFTNLLEQERERLKKLLEQEKAYQARKEKENAKRLNKLRDELVKLKSFALMLVDERQMHIEQLGLQSQKVQDLTQKLREEEEKLKAITSKSKEDRQKLLKLEVDFEHKASRFSQEHEEMNAKLANQESHNRQLRLKLVGLTQRIEELEETNKNLQKAEEELQELRDKIAKGECGNSSLMAEVENLRKRVLEMEGKDEEITKTESQCRELRKKLQEEEHHSKELRLEVEKLQKRMSELEKLEEAFSKSKSECTQLHLNLEKEKNLTKDLLNELEVVKSRVKELECSESRLEKAELSLKDDLTKLKSFTVMLVDERKNMMEKIKQEERKVDGLNKNFKVEQGKVMDVTEKLIEESKKLLKLKSEMEEKVYNLTRERDELIGKLKSEEEKSSELSCSVDLLKKRLDGIEEVEREITRGRSRKGSELTCPEDNKIKELTLEIERLKKRLQQLEVVEGDLMKTEDEYDQLEQKFRTEQDKANFLSQQLEEIKHQIAKNKAIEKGEVVSQEAELRHRFRLEEAKSRDLKAEVQALKEKIHELMNKEDQLSQLQVDYSVLQQRFMEEENKNKNMGQEVLNLTKELELSKRYSRALRPSVNGRRMVDVPVTSTGVQTDAVSGEAAEEETPAVFIRKSFQEENHIMSNLRQVGLKKPVERSSVLDRYPPAANELTMRKSWIPWMRKRENGPSITQEKGPRTNSSPGHPGEVVLSPKQGQPLHIRVTPDHENSTATLEITSPTSEEFFSSTTVIPTLGNQKPRITIIPSPNVMPQKQKSGDTTLGPERAMSPVTITTFSREKTPESGRGAFADRPTSPIQIMTVSTSAAPAEIAVSPESQEMPMGRTILKVTPEKQTVPTPVRKYNSNANIITTEDNKIHIHLGSQFKRSPGTSGEGVSPVITVRPVNVTAEKEVSTGTVLRSPRNHLSSRPGASKVTSTITITPVTTSSARGTQSVSGQDGSSQRPTPTRIPMSKGMKAGKPVVAAPGAGNLTKFEPRAETQSMKIELKKSAASSTTSLGGGKG EE4329B03516E6AF kap1_human cAMP-dependent protein kinase type I-beta regulatory subunit PRKAR1B protein protein human Homo sapiens Human MASPPACPSEEDESLKGCELYVQLHGIQQVLKDCIVHLCISKPERPMKFLREHFEKLEKEENRQILARQKSNSQSDSHDEEVSPTPPNPVVKARRRRGGVSAEVYTEEDAVSYVRKVIPKDYKTMTALAKAISKNVLFAHLDDNERSDIFDAMFPVTHIAGETVIQQGNEGDNFYVVDQGEVDVYVNGEWVTNISEGGSFGELALIYGTPRAATVKAKTDLKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLEKWERLTVADALEPVQFEDGEKIVVQGEPGDDFYIITEGTASVLQRRSPNEEYVEVGRLGPSDYFGEIALLLNRPRAATVVARGPLKCVKLDRPRFERVLGPCSEILKRNIQRYNSFISLTV 1ED7BFEC30897191 tbd2a_human TBC1 domain family member 2A TBC1D2 Armus PARIS1 PP8997 Prostate antigen recognized and identified by SEREX 1 TBC1D2A protein protein human Homo sapiens Human MEGAGENAPESSSSAPGSEESARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKGPIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKADAEEGIFEIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNSPPAPPATPDAALAGNGPVLHLELGQEEAELEEFLCPVKTPPGLVGVAAALQPFPALQNISLKHLGTEIQNTMHNIRGNKQAQGTGHEPPGEDSPQSGEPQREEQPLASDASTPGREPEDSPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTAQEKVAALEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIAELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFTHPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKVAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQEALGDEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLRERWAALGDLVPSAELKQLLRAGVPREHRPRVWRWLVHLRVQHLHTPGCYQELLSRGQAREHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGTKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA 08D7BC167B234CDA glyr1_human Putative oxidoreductase GLYR1 HIBDL NP60 3-hydroxyisobutyrate dehydrogenase-like protein Cytokine-like nuclear factor N-PAC Glyoxylate reductase 1 homolog Nuclear protein NP60 Nuclear protein of 60 kDa GLYR1 NDF Nucleosome-destabilizing factor protein protein human Homo sapiens Human MAAVSLRLGDLVWGKLGRYPPWPGKIVNPPKDLKKPRGKKCFFVKFFGTEDHAWIKVEQLKPYHAHKEEMIKINKGKRFQQAVDAVEEFLRRAKGKDQTSSHNSSDDKNRRNSSEERSRPNSGDEKRKLSLSEGKVKKNMGEGKKRVSSGSSERGSKSPLKRAQEQSPRKRGRPPKDEKDLTIPESSTVKGMMAGPMAAFKWQPTASEPVKDADPHFHHFLLSQTEKPAVCYQAITKKLKICEEETGSTSIQAADSTAVNGSITPTDKKIGFLGLGLMGSGIVSNLLKMGHTVTVWNRTAEKCDLFIQEGARLGRTPAEVVSTCDITFACVSDPKAAKDLVLGPSGVLQGIRPGKCYVDMSTVDADTVTELAQVIVSRGGRFLEAPVSGNQQLSNDGMLVILAAGDRGLYEDCSSCFQAMGKTSFFLGEVGNAAKMMLIVNMVQGSFMATIAEGLTLAQVTGQSQQTLLDILNQGQLASIFLDQKCQNILQGNFKPDFYLKYIQKDLRLAIALGDAVNHPTPMAAAANEVYKRAKALDQSDNDMSAVYRAYIH 2327FC8164B338B7 rhg35_human Rho GTPase-activating protein 35 Glucocorticoid receptor repression factor 1 Rho GAP p190A Glucocorticoid receptor DNA-binding factor 1 GRF1 KIAA1722 ARHGAP35 GRLF1 P190A p190ARHOGAP protein protein human Homo sapiens Human MMMARKQDVRIPTYNISVVGLSGTEKEKGQCGIGKSCLCNRFVRPSADEFHLDHTSVLSTSDFGGRVVNNDHFLYWGEVSRSLEDCVECKMHIVEQTEFIDDQTFQPHRSTALQPYIKRAAATKLASAEKLMYFCTDQLGLEQDFEQKQMPDGKLLVDGFLLGIDVSRGMNRNFDDQLKFVSNLYNQLAKTKKPIVVVLTKCDEGVERYIRDAHTFALSKKNLQVVETSARSNVNVDLAFSTLVQLIDKSRGKTKIIPYFEALKQQSQQIATAKDKYEWLVSRIVKNHNENWLSVSRKMQASPEYQDYVYLEGTQKAKKLFLQHIHRLKHEHIERRRKLYLAALPLAFEALIPNLDEIDHLSCIKAKKLLETKPEFLKWFVVLEETPWDATSHIDNMENERIPFDLMDTVPAEQLYEAHLEKLRNERKRVEMRRAFKENLETSPFITPGKPWEEARSFIMNEDFYQWLEESVYMDIYGKHQKQIIDKAKEEFQELLLEYSELFYELELDAKPSKEKMGVIQDVLGEEQRFKALQKLQAERDALILKHIHFVYHPTKETCPSCPACVDAKIEHLISSRFIRPSDRNQKNSLSDPNIDRINLVILGKDGLARELANEIRALCTNDDKYVIDGKMYELSLRPIEGNVRLPVNSFQTPTFQPHGCLCLYNSKESLSYVVESIEKSRESTLGRRDNHLVHLPLTLILVNKRGDTSGETLHSLIQQGQQIASKLQCVFLDPASAGIGYGRNINEKQISQVLKGLLDSKRNLNLVSSTASIKDLADVDLRIVMCLMCGDPFSADDILFPVLQSQTCKSSHCGSNNSVLLELPIGLHKKRIELSVLSYHSSFSIRKSRLVHGYIVFYSAKRKASLAMLRAFLCEVQDIIPIQLVALTDGAVDVLDNDLSREQLTEGEEIAQEIDGRFTSIPCSQPQHKLEIFHPFFKDVVEKKNIIEATHMYDNAAEACSTTEEVFNSPRAGSPLCNSNLQDSEEDIEPSYSLFREDTSLPSLSKDHSKLSMELEGNDGLSFIMSNFESKLNNKVPPPVKPKPPVHFEITKGDLSYLDQGHRDGQRKSVSSSPWLPQDGFDPSDYAEPMDAVVKPRNEEENIYSVPHDSTQGKIITIRNINKAQSNGSGNGSDSEMDTSSLERGRKVSIVSKPVLYRTRCTRLGRFASYRTSFSVGSDDELGPIRKKEEDQASQGYKGDNAVIPYETDEDPRRRNILRSLRRNTKKPKPKPRPSITKATWESNYFGVPLTTVVTPEKPIPIFIERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFTVNTVAGAMKSFFSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLNKVSHNNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQCPFFFYNRPITEPPGARPSSPSAVASTVPFLTSTPVTSQPSPPQSPPPTPQSPMQPLLPSQLQAEHTL DIP protein Q9NRY4 original sequence version: 146 8CCB493414A7E3E6 q6fhl8_human CTGF protein protein human Homo sapiens Human MTAASMGPVRVAFVVLLALCSRPAVGQNCSGPCRYPDEPAPRCPAGVSLVLDGCGCCRVCAKQLGELCTERDPCDPHKGLFCDFGSPANRKIGVCTAKDGAPCIFGGTVYRSGESFQSSCKYQCTCLDGAVGCMPLCSMDVRLPSPDCPFPRRVKLPGKCCEEWVCDEPKDQTVVGPALAAYRLEDTFGPDPTMIRANCLVQTTEWSACSKTCGMGISTRVTNDNASCRLEKQSRLCMVRPCEADLEENIKKGKKCIRTPKISKPIKFELSGCTSMKTYRAKFCGVCTDGRCCTPHRTTTLPVEFKCPDGEVMKKNMMFIKTCACHYNCPGDNDIFESLYYRKMYGDMA 8CC6999641511188 12346qwet-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 18:59:55 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 20:03:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 22 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-1 cdc42-ranbp9-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:58:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:02:40 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 13 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-2 cdc42-fhod1-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 19:10:37 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 16:06:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 29 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-3 cdc42-myo9a-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:24:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 18:00:16 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 40 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-4 cdc42-prkar1b-1 7 41 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:50:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 18:57:14 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' physical association physical association Table S1-5 cdc42-tbc1d2-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 16:36:33 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 17:56:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 35 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-6 cdc42-mpp5-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:12:18 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 18:47:46 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 36 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-7 cdc42-brms1-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 20:12:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 20:19:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 18 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-8 cdc42-prkra-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:19:47 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:02:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 15 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-9 cdc42-psmc4-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:37:18 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 20:06:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 14 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-10 cdc42-apc-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:11:33 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 15:47:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 16 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-11 cdc42-arhgef3-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:18:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 16:47:32 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 37 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-12 cdc42-cenpc-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 19:43:08 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 16:53:33 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 11 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-13 cdc42-cog1-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 19:04:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 16:13:03 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 44 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-14 cdc42-ctgf-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 18:30:32 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:54:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 42 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-15 cdc42-glyr1-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:34:45 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:30:02 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 39 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-16 cdc42-filip1-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 14:25:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 17:37:19 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 43 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-17 cdc42-arhgap35-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 20:07:13 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 20:15:00 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 31 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-18 cdc42-htra1-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 16:46:33 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 17:10:09 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 17 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-19 cdc42-mcm7-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 19:46:27 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:21:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 28 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-20 cdc42-arhgef40-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 16:03:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:19:21 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 10 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-21 cdc42-sh3rf1-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 14:50:10 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:12:13 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 26 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-22 cdc42-pcgf6-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:13:19 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 16:48:37 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 38 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-23 cdc42-plekhg4-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 17:48:05 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 16:26:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 30 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-24 cdc42-tbc1d4-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 17:43:50 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:55:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 19 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-25 cdc42-usf2-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 19:12:43 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 18:10:05 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 9 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Table S1-26 cdc42-apc-2 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 18:16:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 17:12:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 14 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain physical association physical association Figure 2iB, Supp. fig 1ii cdc42-apc-3 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 16:38:26 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 16:50:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 24 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Figure 2iA, Supp. fig 1ii Positive control cdc42-ranbp9-2 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 16:45:31 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 15:35:51 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 24 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Text only-1 cdc42-wasl-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 19:15:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 16:22:39 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 21 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Text only-2 cdc42-tnk2-1 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 14:42:14 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 15:49:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 32 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Text only-3 cdc42-pak2-2 7 25 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 20:32:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 17:35:04 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' physical association physical association Text only-4 cdc42-pak2-3 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 19:47:34 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:42:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 20 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Text only-5 IRSp58/p53. cdc42-baiap2-2 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 19:42:33 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 15:59:30 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 33 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Text only-6 IRSp58/p53. cdc42-pard6a-3 7 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 15:58:55 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 18:08:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 34 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Text only-7 IRSp58/p53. cdc42-apc-4 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 20:19:31 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:31:55 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 34 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Figure Supp. fig 1ii-1 cdc42-cdc23-1 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain Q L certain certain sequence position certain certain certain sequence position certain C S Wed May 02 17:18:31 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Wed May 02 17:31:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 16:15:17 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 22 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Figure Supp. fig 1ii-2 cdc42-ranbp9-3 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain C S certain certain sequence position certain certain certain sequence position certain Q L Wed May 02 20:13:16 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 18:00:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 37 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Figure Supp. fig 1ii-3 cdc42-cenpc-2 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain C S certain certain sequence position certain certain certain sequence position certain Q L Wed May 02 16:49:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 18:44:08 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 13 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Figure Supp. fig 1ii-4 cdc42-fhod1-2 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain C S certain certain sequence position certain certain certain sequence position certain Q L Wed May 02 17:41:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:11:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 39 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Figure Supp. fig 1ii-5 cdc42-filip1-2 5 41 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain C S certain certain sequence position certain certain certain sequence position certain Q L Wed May 02 15:26:28 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 18:01:27 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' physical association physical association Figure Supp. fig 1ii-6 cdc42-tbc1d2-2 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain C S certain certain sequence position certain certain certain sequence position certain Q L Wed May 02 18:31:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 18:11:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 40 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Figure Supp. fig 1ii-7 cdc42-prkar1b-2 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain C S certain certain sequence position certain certain certain sequence position certain Q L Wed May 02 16:43:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 19:34:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 18 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Figure Supp. fig 1ii-8 cdc42-prkra-2 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain C S certain certain sequence position certain certain certain sequence position certain Q L Wed May 02 17:25:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 20:01:38 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 36 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Figure Supp. fig 1ii-9 cdc42-brms1-2 5 12 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed P60953-1:p.[Gln61Leu;Cys189Ser] mutation mutation certain certain sequence position certain certain certain sequence position certain C S certain certain sequence position certain certain certain sequence position certain Q L Wed May 02 20:09:41 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln61leu,cys189ser' Tue Jun 30 18:09:08 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Gln61Leu;Cys189Ser]' 17 unspecified role unspecified role prey prey over-expressed over expressed level over-expressed physical association physical association Figure Supp. fig 1ii-10 cdc42-apc-5 6 14 unspecified role unspecified role prey prey partially purified partially purified in vitro translated in vitro translated protein in vitro translated region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined in vitro In vitro 23 unspecified role unspecified role bait bait purified purified region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined P60953:p.Gly12Val mutation mutation certain certain sequence position certain certain certain sequence position certain G V Wed May 02 16:10:37 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly12val' Tue Jun 30 17:53:44 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly12Val' P60953:p.Thr17Asn mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain T N Wed May 02 18:05:11 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr17asn' Tue Jun 30 17:43:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr17Asn' physical association physical association Figure 2ii cdc42-apc-6 6 20 unspecified role unspecified role prey prey partially purified partially purified in vitro translated in vitro translated protein in vitro translated region 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined in vitro In vitro 23 unspecified role unspecified role bait bait purified purified region gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined P60953:p.Gly12Val mutation mutation certain certain sequence position certain certain certain sequence position certain G V Wed May 02 15:26:00 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly12val' Tue Jun 30 16:05:34 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly12Val' physical association physical association Figure 2ii-2 positive control 12346qwerry-1 3 14 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept over-expressed over expressed level over-expressed fixed cell fixed cell arm_regions sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region rfp tag red fluorescent protein tag red fluorescent protein RFP red fluorescent protein RFP rfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 23 unspecified role unspecified role fluorescence donor fluorescence donor over-expressed over expressed level over-expressed fixed cell fixed cell P60953:p.Gly12Val mutation mutation certain certain sequence position certain certain certain sequence position certain G V Wed May 02 20:09:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly12val' Tue Jun 30 17:38:50 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly12Val' region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined P60953:p.Thr17Asn mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain T N Wed May 02 15:17:52 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr17asn' Tue Jun 30 17:17:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr17Asn' proximity proximity close-contact colocalization neighbourhood interaction Figure 2iii/v cdc42-apc-7 3 14 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept over-expressed over expressed level over-expressed fixed cell fixed cell region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region rfp tag red fluorescent protein tag red fluorescent protein RFP red fluorescent protein RFP rfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 27 unspecified role unspecified role fluorescence donor fluorescence donor over-expressed over expressed level over-expressed fixed cell fixed cell P63000:p.Gly12Val mutation mutation certain certain sequence position certain certain certain sequence position certain G V Wed May 02 18:22:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly12val' Tue Jun 30 18:04:58 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly12Val' region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined proximity proximity close-contact colocalization neighbourhood interaction Figure 2iii/v-2 weak interaction cdc42-apc-8 2 14 unspecified role unspecified role fluorescence donor fluorescence donor over-expressed over expressed level over-expressed fixed cell fixed cell region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 23 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept over-expressed over expressed level over-expressed fixed cell fixed cell P60953:p.Gly12Val mutation mutation certain certain sequence position certain certain certain sequence position certain G V Wed May 02 18:04:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly12val' Tue Jun 30 18:28:57 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly12Val' region rfp tag red fluorescent protein tag red fluorescent protein RFP red fluorescent protein RFP rfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined P60953:p.Thr17Asn mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength certain certain sequence position certain certain certain sequence position certain T N Wed May 02 15:38:45 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr17asn' Tue Jun 30 18:36:38 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr17Asn' proximity proximity close-contact colocalization neighbourhood interaction Figure 3iii-v cdc42-apc-9 3 14 unspecified role unspecified role fluorescence donor fluorescence donor over-expressed over expressed level over-expressed fixed cell fixed cell region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 23 unspecified role unspecified role fluorescence accept fluorescence acceptor fluorescence accept over-expressed over expressed level over-expressed fixed cell fixed cell P60953:p.Gly12Val mutation mutation certain certain sequence position certain certain certain sequence position certain G V Wed May 02 19:51:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly12val' Tue Jun 30 16:15:05 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly12Val' region rfp tag red fluorescent protein tag red fluorescent protein RFP red fluorescent protein RFP rfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined proximity proximity close-contact colocalization neighbourhood interaction Figure 3ii Cdc42V12 interacted with GFP-APC in the cytoplasm and also at the leading edges of cells. In addition, Cdc42V12 and GFP-APC1–1638 interacted in puncta. I have not added any GO terms, as for FRET we do not usually enter any colocalisation terms - and I am not sure how they manage to say that any is shown here. (I can see puncta - but the rest??) 521543q4reate-1 8 14 unspecified role unspecified role prey prey living cell living cell physiological level physiological level endogenous level endogenous endogenous endogenous level 23 unspecified role unspecified role bait bait over-expressed over expressed level over-expressed living cell living cell region rfp tag red fluorescent protein tag red fluorescent protein RFP red fluorescent protein RFP rfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region sbp sbp undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined P60953:p.Gly12Val mutation mutation certain certain sequence position certain certain certain sequence position certain G V Wed May 02 14:32:28 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly12val' Tue Jun 30 16:28:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly12Val' physical association physical association Figure 3vii apc-cdc42-1 4 14 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 23 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell P60953:p.Gly12Val mutation mutation certain certain sequence position certain certain certain sequence position certain G V Wed May 02 17:10:44 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly12val' Tue Jun 30 16:08:46 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly12Val' region rfp tag red fluorescent protein tag red fluorescent protein RFP red fluorescent protein RFP rfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization Figure 4i, 4iii no info is given as to wether results with CDC42N17 are positive - or presumably reduced/absent colocalisation - only "possible" coloc is stated. As I dont know what they mean here, if anything, - I have omitted this mutation. apc-cdc42-2 4 14 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain region gfp tag green fluorescent protein tag GFP green fluorescent protein GFP green fluorescent protein gfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 23 immunocytochemistry immunocytochemistry tag fluorescence tag visualisation by fluorescence tag fluorescence unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell P60953:p.Gly12Val mutation mutation certain certain sequence position certain certain certain sequence position certain G V Wed May 02 14:57:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly12val' Tue Jun 30 17:47:38 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly12Val' region ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization Figure 4ii, 5i-c no info is given as to wether results with CDC42N17 are positive - or presumably reduced/absent colocalisation - only "possible" coloc is stated. As I dont know what they mean here, if anything, - I have omitted this mutation. apc-cdc42-3 1 14 unspecified role unspecified role neutral component neutral component physiological level physiological level endogenous level endogenous endogenous endogenous level fixed cell fixed cell 23 unspecified role unspecified role neutral component neutral component over-expressed over expressed level over-expressed fixed cell fixed cell P60953:p.Gly12Val mutation mutation certain certain sequence position certain certain certain sequence position certain G V Wed May 02 16:02:35 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gly12val' Tue Jun 30 19:10:31 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gly12Val' region rfp tag red fluorescent protein tag red fluorescent protein RFP red fluorescent protein RFP rfp tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined colocalization colocalization Figure 5ii/iii Cdc42N17:- stated "mRFP-Cdc42V12, it induced the translocation of full-length APC to the leading edge in HCT116 cells as seen by a line intensity analysis but mRFP-Cdc42N17 did not-(Fig. 5(ii) panel d). " As I cannot see any lines on (Fig. 5(ii) panel d). - I have omitted this mutation. In HCT116 cells, actin and APC were found to colocalize at the leading edge. In HCT116 cells, actin and APC were found to colocalize at the leading edge cannot enter "actin" as a GO term - dont know which one to use, as "filaments" are not specified here.