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  <entry>
    <source releaseDate="2022-02-04">
      <names>
        <shortLabel>IntAct</shortLabel>
        <fullName>European Bioinformatics Institute</fullName>
        <alias type="synonym" typeAc="MI:1041">IntAct</alias>
        <alias type="synonym" typeAc="MI:1041">intact</alias>
      </names>
      <bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
      </bibref>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0469" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-10" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681455" refType="primary-reference" refTypeAc="MI:0358"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="22121220" refType="method reference" refTypeAc="MI:0357"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="19850723" refType="method reference" refTypeAc="MI:0357"/>
      </xref>
      <attributeList>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/</attribute>
        <attribute name="search-url" nameAc="MI:0615">http://www.ebi.ac.uk/intact/query/${ac}</attribute>
        <attribute name="id-validation-regexp" nameAc="MI:0628">EBI-[0-9]+|IA:[0-9]+</attribute>
        <attribute name="definition">INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions.</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact</attribute>
        <attribute name="postaladdress">European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom</attribute>
        <attribute name="url" nameAc="MI:0614">http://www.ebi.ac.uk/intact/</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="9625766" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-13915709" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-25815" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis.</attribute>
            <attribute name="journal" nameAc="MI:0885">The Journal of experimental medicine</attribute>
            <attribute name="publication year" nameAc="MI:0886">1998</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Vitale M., Bottino C., Sivori S., Sanseverino L., Castriconi R., Marcenaro E., Augugliaro R., Moretta L., Moretta A.</attribute>
            <attribute name="remark-internal">DSP=?74.&#xd;
First one from PAblo's list.  The stated pair is O43914_O95944 - but I found it to be as entered. (p44 does not interact, but p46 (NKp46) does. There is also an interaction with CC 16 - but not specific to any one form of CD16-so not entered.</attribute>
            <attribute name="data-processing" nameAc="MI:0633">Interaction with CC 16 not recorded because antibody used was not specific to any one form of CD16.</attribute>
            <attribute name="contact-email" nameAc="MI:0634">miriello@sirio.cba.unige.it</attribute>
            <attribute name="author-announcement">05-Sep-2017: Contacted by IntAct-Help.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="pubmed" dbAc="MI:0446" id="9625766" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-25815" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="9606">
            <names>
              <shortLabel>human-nk_cells</shortLabel>
              <fullName>human-Natural Killer cells</fullName>
              <alias type="synonym" typeAc="MI:1041">Human</alias>
            </names>
            <tissue>
              <names>
                <shortLabel>nk_cells</shortLabel>
                <fullName>Natural killer cells</fullName>
              </names>
              <xref>
                <primaryRef db="intact" dbAc="MI:0469" id="IA:3125" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="brenda" dbAc="MI:0864" id="BTO:0000914" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-13915723" refType="identity" refTypeAc="MI:0356"/>
              </xref>
            </tissue>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>anti bait coip</shortLabel>
            <fullName>anti bait coimmunoprecipitation</fullName>
            <alias type="synonym" typeAc="MI:1041">anti bait coip</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0006" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-976" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="7708014" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>western blot</shortLabel>
            <fullName>western blot</fullName>
            <alias type="go synonym" typeAc="MI:0303">Immuno blot</alias>
            <alias type="synonym" typeAc="MI:1041">Immuno blot</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0113" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-973" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Vitale M., Bottino C., Sivori S., Sanseverino L., Castriconi R., Marcenaro E., Augugliaro R., Moretta L., Moretta A.</attribute>
          <attribute name="remark-internal">DSP=?74.&#xd;
First one from PAblo's list.  The stated pair is O43914_O95944 - but I found it to be as entered. (p44 does not interact, but p46 (NKp46) does. There is also an interaction with CC 16 - but not specific to any one form of CD16-so not entered.</attribute>
          <attribute name="data-processing" nameAc="MI:0633">Interaction with CC 16 not recorded because antibody used was not specific to any one form of CD16.</attribute>
          <attribute name="contact-email" nameAc="MI:0634">miriello@sirio.cba.unige.it</attribute>
          <attribute name="accepted">Accepted 2017-AUG-08 AT 16:58 BST AT 16:58 BST by PPORRAS</attribute>
          <attribute name="journal" nameAc="MI:0885">The Journal of experimental medicine</attribute>
          <attribute name="publication year" nameAc="MI:0886">1998</attribute>
          <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
          <attribute name="imex curation" nameAc="MI:0959">imex curation</attribute>
          <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>nctr1_human</shortLabel>
          <fullName>Natural cytotoxicity triggering receptor 1</fullName>
          <alias type="gene name" typeAc="MI:0301">NCR1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">LY94</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Lymphocyte antigen 94 homolog</alias>
          <alias type="gene name synonym" typeAc="MI:0302">NK cell-activating receptor</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Natural killer cell p46-related protein</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="O76036" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B0V3L2" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B0V3L3" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B0V3L4" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B0V3L5" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="B8JL03" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O76016" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O76017" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="O76018" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000478507" version="SP_174" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000481971" version="SP_174" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000482423" version="SP_174" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000484520" version="SP_174" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-13915737" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001138929.2"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001138930.2"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229285.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001229286.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_004820.2"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000273535" version="SP_174" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000275156" version="SP_174" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000278362" version="SP_174" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000610621" version="SP_174" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000612896" version="SP_174" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000615622" version="SP_174" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000617154" version="SP_174" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000617784" version="SP_174" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000619077" version="SP_174" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005886" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005887" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006968" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007165" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016514" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030101" version="SP_174"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042269" version="SP_174"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003599" version="SP_174"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013783" version="SP_174"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036179" version="SP_174"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1OLL" version="SP_174"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1P6F" version="SP_174"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6IAP" version="SP_174"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-198933" version="SP_174"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MSSTLPALLCVGLCLSQRISAQQQTLPKPFIWAEPHFMVPKEKQVTICCQGNYGAVEYQLHFEGSLFAVDRPKPPERINKVKFYIPDMNSRMAGQYSCIYRVGELWSEPSNLLDLVVTEMYDTPTLSVHPGPEVISGEKVTFYCRLDTATSMFLLLKEGRSSHVQRGYGKVQAEFPLGPVTTAHRGTYRCFGSYNNHAWSFPSEPVKLLVTGDIENTSLAPEDPTFPADTWGTYLLTTETGLQKDHALWDHTAQNLLRMGLAFLVLVALVWFLVEDWLSRKRTRERASRASTWEGRRRLNTQTL</sequence>
        <attributeList>
          <attribute name="crc64">FBCBDE50D2F34CD3</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>cd3e_human</shortLabel>
          <fullName>T-cell surface glycoprotein CD3 epsilon chain</fullName>
          <alias type="gene name" typeAc="MI:0301">CD3E</alias>
          <alias type="gene name synonym" typeAc="MI:0302">T3E</alias>
          <alias type="gene name synonym" typeAc="MI:0302">T-cell surface antigen T3/Leu-4 epsilon chain</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P07766" version="SP_88" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="A8K997" version="SP_112" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-28973315" refType="intact-secondary"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000354566" version="SP_217" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1211297" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_000724.1"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000354566"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000198851" version="SP_217" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000361763" version="SP_217" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001772" version="SP_217"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007186" version="SP_217"/>
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          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009897" version="SP_217"/>
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          <secondaryRef db="mint" dbAc="MI:0471" id="P07766" version="SP_217"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5QU2" version="SP_217"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6JXR" version="SP_217"/>
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          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202424" version="SP_217"/>
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          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-202430" version="SP_217"/>
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          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-389948" version="SP_217"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
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            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MQSGTHWRVLGLCLLSVGVWGQDGNEEMGGITQTPYKVSISGTTVILTCPQYPGSEILWQHNDKNIGGDEDDKNIGSDEDHLSLKEFSELEQSGYYVCYPRGSKPEDANFYLYLRARVCENCMEMDVMSVATIVIVDICITGGLLLLVYYWSKNRKAKAKPVTRGAGAGGRQRGQNKERPPPVPNPDYEPIRKGQRDLYSGLNQRRI</sequence>
        <attributeList>
          <attribute name="crc64">A1603D01CE9957D7</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-25815-1">
        <names>
          <shortLabel>ncr1-cd3e-1</shortLabel>
        </names>
        <xref>
          <primaryRef db="intact" dbAc="MI:0469" id="EBI-13915735" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-25815-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
          <participant id="6">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
        <attributeList>
          <attribute name="figure legend" nameAc="MI:0599">4A</attribute>
        </attributeList>
      </interaction>
    </interactionList>
  </entry>
</entrySet>