DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature 2016 imex curation Li H., O'Donoghue AJ., van der Linden WA., Xie SC., Yoo E., Foe IT., Tilley L., Craik CS., da Fonseca PC., Bogyo M. Only protein-protein interactions plaf7 Plasmodium falciparum (isolate 3D7) 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Li H., O'Donoghue AJ., van der Linden WA., Xie SC., Yoo E., Foe IT., Tilley L., Craik CS., da Fonseca PC., Bogyo M. DIP original experiment: DIP-268644X Nature 2016 IMEx Structure- and function-based design of Plasmodium-selective proteasome inhibitors. q8i261_plaf7 Proteasome subunit beta PF3D7_0108000 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MGSIYNYNGGCVLGMSGSNCVAIACDLRLGANTFTTVSTKFSKIFKMNNNVYVGLSGLATDIQTLYEILRYRVNLYEVRQDAEMDVECFANMLSSILYSNRFSPYFVNPIVVGFKLKHYVDEEGEKKVNYEPYLTAYDLIGAKCETRDFVVNGVTSEQLFGMCESLYVKDQDENGLFETISQCLLSALDRDCISGWGAEVLVLTPEKIIKKKLKARMD DIP protein Q8I261 original sequence version: 86 2F8CA3352EC3BA49 q8i0u7_plaf7 PF3D7_0931800 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MDVVNESQIKCHEEKSWDDEYDIKTPISDGTTIIGIIYDNGVMLACDSRTSSGTFISNKCSRKINRINENLYVCRSGASAHSQKIIEIIKHYCVSMKNENRKKGRFHEGETIYDETTYDEEIDIDSINYLDYNNNNDNNLVTKNKYFYEDKFNDYNPLVENVAHITKKIIYTNNNFLSCALIFGGYDKIKKQQLYAVNLNGSIIEKHDFAVSGSGSIYIQSYLQDKYKKFMTKKECFNLILNCVKYAMHNDNSSGGLIRIVNITKSFVEEFTVVNTQMNFQY DIP protein Q8I0U7 original sequence version: 95 q8i6t3_plaf7 Proteasome subunit beta PF3D7_1328100 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MKLEYINILKEENGGYNFDNLKRNEILKEKGVKFPQFRKTGTTICGLVCQNAVILGADTRATEGPIVADKNCSKLHYISKNIWCAGAGVAGDLEHTTLWLQHNVELHRLNTNTQPRVSMCVSRLTQELFKYQGYKVCAIVLGGVDVNGPQLYGIHPHGSSCLLPFTALGSGSLNAMAVLEAKYRDNMTIEEGKNLVCEAICAGIFNDLGSGGNVDICVITKDSYQHIRPYKEPNMRLYHLPHPTIYPKGTTPILSEKIEYIKKFISVEDA DIP protein Q8I6T3 original sequence version: 96 BCBE04F369AADAAE q8ik90_plaf7 PF3D7_1474800 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MYRNLYDTDNIIYSPEGRLYQVEYASEAIKQGTCAVAIKSKDYVVVSGLKKCISKLSFPQEKIFKIDDYIGISMSGITSDAKVLTKFMQNECLSHKFLYNENINIESLVRSVADKYQKNTQKSSKRAFGVGLMIAAYHNEPCIFETRPNGSYFEYDALSFGARSHASKTYLEKNLHLFEECSLEELILHCLKALKCSLSSESELTISNTALAVVGKNHPWQEISSLQLEEYLSKVKMDAEQEQVEENVQNEANE DIP protein Q8IK90 original sequence version: 97 q7k6a9_plaf7 Proteasome subunit beta PF3D7_0803800 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MTLGPVVTGTSVIAIKYKHGIMIAADRKASYGSYAKFQNVERIFKINNKTVMGFSGELADAQYLHELLTRKNINNLSEKKRKEDMYTPQHYHSYVSRVFYVRKNRIDPLFNNIIIAGINSQKYDNNDDNVLLYTNKNNDDEQNEYKNNEEYKEIHKDDLYIGFVDMHGTNFCDDYITTGYARYFALTLLRDHYKDNMTEEEARILINECLRILYFRDATSSNFIQIVKVTSKGVEYEEPYILPCVLNSADYVYPSTLLPPAGCMW DIP protein Q7K6A9 original sequence version: 85 a0a5k1k7u1_plaf7 Proteasome subunit beta PF3D7_0518300 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MDLILYNDNLTEKKTEKENVIEHGRGFKRWYPYIDNGGTVIGLTGKDYVILAADTRLSLSYSIYTRFCPKISKLTDKCIIGSSGMQSDIKTLHSLLQKKIQLFVLEHSHYPDIHVIARLLCVILYSRRFFPYYAFNILAGVDENNKGVLYNYDSVGSYCEATHSCVGSGSQLILPILDNRVEQKNQLIKNTNFNLGDDINFVKDAITSATERDIYTGDKTLIYVIDKMGINVNTLDLKQD DIP protein C0H4E8 original sequence version: 53 o77396_plaf7 PF3D7_0317000 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MAGLSAGYDLSVSTFSPDGRLYQVEYIYKSINNNNTALCLECKDGIICCCINSNMDKNKMIKKNSYNRIYHVNNNIIITYSGFDGDARNIIDRARSEANTYYYNFHTNIPLHILVNRISLYIHAYTLYWHMRPFAASIIISSFNEKDKGDIYCIEPNGACYKYSGIVIGKNKEMFKTEIEKKDYKDINVRDAIEDIYKFILTSDDHMNKNNLQNLVNFSWICKESSYEFQNIHEEILTPALNKAVEYIEKLN DIP protein O77396 original sequence version: 104 q8ijt1_plaf7 Proteasome subunit beta PF3D7_1011400 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MVIASDESFMNEIDNLINDVEDERIDNDELEFCVAPVNVPRNFIKYAQTQNKKLFDFHKGTTTLAFKFKDGIIVAVDSRASMGSFISSQNVEKIIEINKNILGTMAGGAADCLYWEKYLGKIIKIYELRNNEKISVRAASTILSNILYQYKGYGLCCGIILSGYDHTGFNMFYVDDSGKKVEGNLFSCGSGSTYAYSILDSAYDYNLNLDQAVELARNAIYHATFRDGGSGGKVRVFHIHKNGYDKIIEGEDVFDLHYHYTNPEQKDQYVM DIP protein Q8IJT1 original sequence version: 99 CBDA4F07503EB4E3 c6kst3_plaf7 PF3D7_0608500 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MADGEYSFSLTTFSPTGKLVQIEYALNRVSSSSPALGIRAKNGVIIATEKKSPNELIEENSIFKIQQISEHIGIVYAGMPGDFRVLLKRARKEAIRYSLQYGSEILVKELVKIIASIVQEFTQTGGVRPFGLSLLICGVDVYGYHLYQIDPSGCYFNWMATCVGKDYQNNMSFLEKRYNKDIEIEDAIHTAILTLKESYEGVLNEKNIEIGVAYDNKPFKILTQNEIKDYLIEIE DIP protein C6KST3 original sequence version: 47 E29EA9E6AF3103E3 q8iar3_plaf7 PF3D7_0807500 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MVRPSQSMYDRHLTIFSPDGNLYQIEYAIKAVKNTNITSVGVKGENCAVIISQKKMATQYISQDKLLDYNNITNIYNITDEIGCSMVGMPGDCLSMVYKARSEASEFLYSNGYNVNAETLCRNICDKIQVYTQHAYMRLHACSGMIIGIDENNKPELFKFDPSGFCAGYRACVIGNKEQESISVLERLLEKRKKKIQQETIDEDIRNTTILAIEALQTILAFDLKASEIEVAIVSTKNRNFTQISEKEIDNYLTYIAERD DIP protein Q8IAR3 original sequence version: 88 7236D13D35BCBC14 q8idg3_plaf7 Proteasome subunit alpha type PF3D7_1353800 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MARRYDSRTTTFSPEGRLYQVEYALEAINNASITIGLITKDGVILGADKVFISKLIDKANNYEKIYKIDKHIFCGVAGLNADANILINQSRLYAQRYLYNYNEVQPVSQLVVQICDIKQSYTQYGGLRPYGVSFLIGGYDTKDGYQLYHTDPSGNYSGWFATAIGTNNLTASSVLKQEWKNDMTLEEGLLLALKTLAKSTDTEIPKSEKIELAYLTNKDGEVYQKYLTEKEIEELIKLYTQKYIKE DIP protein Q8IDG3 original sequence version: 90 q8idg2_plaf7 Proteasome subunit alpha type PF3D7_1353900 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MSYDRAITVFSPDGHLLQVEHALEAVKKGGCAVAIKSSNFAVLAVEKKNIPKLQNPKTTEKLIKLDEHNCLAFAGLNADARVLVNKTRLECQRYYLNMDEPAPVDYIAKYVAKVQQKFTHRGGVRPFGIATLIAGFKNNKEICIYQTEPSGIYAAWKAQAIGKNAKIVQEFLEKNYQENMEQKDCIFLALKAIFEVVELSSKNVEVALLTEKDLTFIEEQEINSMVELIDQERTKNNEQNE DIP protein Q8IDG2 original sequence version: 93 q8ikc9_plaf7 Proteasome subunit beta PF3D7_1470900 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MDTLIGLRGNNFVVLAADTYSINSIIKLKNDDNTKFYDIHGNKCLLLGGSIGDRLQFGEFIRKNVHLYQYQNNTDMFVKSFAFFTRKNLAYYLRRNPFEVNCLIAGYDKKDGYQLYWCDYLSNMDSVNKGAHGYGAYLVSAILDKYYHENLTVDEALDIFKLCFEELKKRFLLTQINYELRIMYDNKVETQYVTV DIP protein Q8IKC9 original sequence version: 95 q8ibi3_plaf7 Proteasome subunit alpha type PF3D7_0727400 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MFSTRSEYDRGVNTFSPEGRLFQVEYALGAIKLGSTAVGICVNDGVILASERRISSTLIEKDSVEKLLSIDDHIGCAMSGLMADARTLIDYARVECNHYKFIYNENINIKSCVELISELALDFSNLSDSKRKKIMSRPFGVALLIGGVDKNGPCLWYTEPSGTNTRFSAASIGSAQEGAELLLQENYKKDMTFEQAEILALTVLRQVMEDKLSTSNVEICAIKKSDQTFYKYNTDDISRIIDVLPSPVYPTIDMTA DIP protein Q8IBI3 original sequence version: 95 477C0E76E2D4DCBB c0h4e8_plaf7-c6kst3_plaf7-1 1 6 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 7 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 9 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 14 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 2 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 4 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 3 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 8 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 5 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 15 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 13 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 12 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 10 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) 11 unspecified role unspecified role unspecified role unspecified role plaf7 Plasmodium falciparum (isolate 3D7) physical association physical association