DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature 2016 imex curation Walls AC., Tortorici MA., Bosch BJ., Frenz B., Rottier PJ., DiMaio F., Rey FA., Veesler D. Coronavirus - Interactions investigated in the context of Coronavirus Only protein-protein interactions in vitro In vitro mst microscale thermophoresis mst predetermined predetermined participant predetermined Walls AC., Tortorici MA., Bosch BJ., Frenz B., Rottier PJ., DiMaio F., Rey FA., Veesler D. Coronavirus - Interactions investigated in the context of Coronavirus DIP original experiment: DIP-268725X Nature 2016 IMEx Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature 2016 imex curation Walls AC., Tortorici MA., Bosch BJ., Frenz B., Rottier PJ., DiMaio F., Rey FA., Veesler D. Coronavirus - Interactions investigated in the context of Coronavirus Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Walls AC., Tortorici MA., Bosch BJ., Frenz B., Rottier PJ., DiMaio F., Rey FA., Veesler D. Coronavirus - Interactions investigated in the context of Coronavirus DIP original experiment: DIP-268724X Nature 2016 IMEx Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature 2016 imex curation Walls AC., Tortorici MA., Bosch BJ., Frenz B., Rottier PJ., DiMaio F., Rey FA., Veesler D. Coronavirus - Interactions investigated in the context of Coronavirus Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly light scattering light scattering predetermined predetermined participant predetermined Walls AC., Tortorici MA., Bosch BJ., Frenz B., Rottier PJ., DiMaio F., Rey FA., Veesler D. Coronavirus - Interactions investigated in the context of Coronavirus DIP original experiment: DIP-268723X Nature 2016 IMEx Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. Nature 2016 imex curation Walls AC., Tortorici MA., Bosch BJ., Frenz B., Rottier PJ., DiMaio F., Rey FA., Veesler D. Coronavirus - Interactions investigated in the context of Coronavirus Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Walls AC., Tortorici MA., Bosch BJ., Frenz B., Rottier PJ., DiMaio F., Rey FA., Veesler D. Coronavirus - Interactions investigated in the context of Coronavirus DIP original experiment: DIP-268722X Nature 2016 IMEx Cryo-electron microscopy structure of a coronavirus spike glycoprotein trimer. ceam1_mouse Carcinoembryonic antigen-related cell adhesion molecule 1 Ceacam1 Bgp Bgp1 Biliary glycoprotein 1 Murine hepatitis virus receptor MHVR1 Biliary glycoprotein D protein protein mouse Mus musculus Mouse MELASAHLHKGQVPWGGLLLTASLLASWSPATTAEVTIEAVPPQVAEDNNVLLLVHNLPLALGAFAWYKGNTTAIDKEIARFVPNSNMNFTGQAYSGREIIYSNGSLLFQMITMKDMGVYTLDMTDENYRRTQATVRFHVHPILLKPNITSNNSNPVEGDDSVSLTCDSYTDPDNINYLWSRNGESLSEGDRLKLSEGNRTLTLLNVTRNDTGPYVCETRNPVSVNRSDPFSLNIIYGPDTPIISPSDIYLHPGSNLNLSCHAASNPPAQYFWLINEKPHASSQELFIPNITTNNSGTYTCFVNNSVTGLSRTTVKNITVLEPVTQPFLQVTNTTVKELDSVTLTCLSNDIGANIQWLFNSQSLQLTERMTLSQNNSILRIDPIKREDAGEYQCEISNPVSVRRSNSIKLDIIFDPTQGGLSDGAIAGIVIGVVAGVALIAGLAYFLYSRKSGGGSDQRDLTEHKPSTSNHNLAPSDNSPNKVDDVAYTVLNFNSQQPNRPTSAPSSPRATETVYSEVKKK DIP protein P31809 original sequence version: 135 DIP protein P31809-1 original sequence version: 146 mint Unknown. In case of murine coronavirus (MHV) infection, serves as receptor for MHV S1 spike glycoprotein 1C8F71FAC47DD54E spike_cvma5 Spike glycoprotein S E2 Peplomer protein 3 protein protein cvma5 Murine coronavirus (strain A59) MHV-A59 Murine hepatitis virus MLFVFILFLPSCLGYIGDFRCIQLVNSNGANVSAPSISTETVEVSQGLGTYYVLDRVYLNATLLLTGYYPVDGSKFRNLALRGTNSVSLSWFQPPYLNQFNDGIFAKVQNLKTSTPSGATAYFPTIVIGSLFGYTSYTVVIEPYNGVIMASVCQYTICQLPYTDCKPNTNGNKLIGFWHTDVKPPICVLKRNFTLNVNADAFYFHFYQHGGTFYAYYADKPSATTFLFSVYIGDILTQYYVLPFICNPTAGSTFAPRYWVTPLVKRQYLFNFNQKGVITSAVDCASSYTSEIKCKTQSMLPSTGVYELSGYTVQPVGVVYRRVANLPACNIEEWLTARSVPSPLNWERKTFQNCNFNLSSLLRYVQAESLFCNNIDASKVYGRCFGSISVDKFAVPRSRQVDLQLGNSGFLQTANYKIDTAATSCQLHYTLPKNNVTINNHNPSSWNRRYGFNDAGVFGKNQHDVVYAQQCFTVRSSYCPCAQPDIVSPCTTQTKPKSAFVNVGDHCEGLGVLEDNCGNADPHKGCICANNSFIGWSHDTCLVNDRCQIFANILLNGINSGTTCSTDLQLPNTEVVTGICVKYDLYGITGQGVFKEVKADYYNSWQTLLYDVNGNLNGFRDLTTNKTYTIRSCYSGRVSAAFHKDAPEPALLYRNINCSYVFSNNISREENPLNYFDSYLGCVVNADNRTDEALPNCDLRMGAGLCVDYSKSRRAHRSVSTGYRLTTFEPYTPMLVNDSVQSVDGLYEMQIPTNFTIGHHEEFIQTRSPKVTIDCAAFVCGDNTACRQQLVEYGSFCVNVNAILNEVNNLLDNMQLQVASALMQGVTISSRLPDGISGPIDDINFSPLLGCIGSTCAEDGNGPSAIRGRSAIEDLLFDKVKLSDVGFVEAYNNCTGGQEVRDLLCVQSFNGIKVLPPVLSESQISGYTTGATAAAMFPPWSAAAGVPFSLSVQYRINGLGVTMNVLSENQKMIASAFNNALGAIQDGFDATNSALGKIQSVVNANAEALNNLLNQLSNRFGAISASLQEILTRLEAVEAKAQIDRLINGRLTALNAYISKQLSDSTLIKVSAAQAIEKVNECVKSQTTRINFCGNGNHILSLVQNAPYGLYFIHFSYVPISFTTANVSPGLCISGDRGLAPKAGYFVQDDGEWKFTGSSYYYPEPITDKNSVIMSSCAVNYTKAPEVFLNTSIPNPPDFKEELDKWFKNQTSIAPDLSLDFEKLNVTLLDLTYEMNRIQDAIKKLNESYINLKEVGTYEMYVKWPWYVWLLIGLAGVAVCVLLFFICCCTGCGSCCFKKCGNCCDEYGGHQDSIVIHNISSHED DIP protein P11224 original sequence version: 119 ceacam1-s-1 1 5 unspecified role unspecified role unspecified role unspecified role Region 35-142 Region 35-142 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 6 unspecified role unspecified role unspecified role unspecified role Region 15-1231 Region 15-1231 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly direct interaction direct interaction s-11 4 6 unspecified role unspecified role unspecified role unspecified role Region 15-1231 Region 15-1231 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly direct interaction direct interaction s-12 3 6 unspecified role unspecified role unspecified role unspecified role Region 15-1231 Region 15-1231 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly direct interaction direct interaction s-13 2 6 unspecified role unspecified role unspecified role unspecified role Region 15-1231 Region 15-1231 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly direct interaction direct interaction