DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. Nature 2016 imex curation Oldham ML., Hite RK., Steffen AM., Damko E., Li Z., Walz T., Chen J. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Oldham ML., Hite RK., Steffen AM., Damko E., Li Z., Walz T., Chen J. DIP original experiment: DIP-268579X Nature 2016 IMEx A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. Nature 2016 imex curation Oldham ML., Hite RK., Steffen AM., Damko E., Li Z., Walz T., Chen J. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Oldham ML., Hite RK., Steffen AM., Damko E., Li Z., Walz T., Chen J. DIP original experiment: DIP-268578X Nature 2016 IMEx A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. Nature 2016 imex curation Oldham ML., Hite RK., Steffen AM., Damko E., Li Z., Walz T., Chen J. Only protein-protein interactions in vitro In vitro 3d-em 3D electron microscopy 3D-EM electron tomog predetermined predetermined participant predetermined Oldham ML., Hite RK., Steffen AM., Damko E., Li Z., Walz T., Chen J. DIP original experiment: DIP-268580X Nature 2016 IMEx A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter. icp47_hhv11 ICP47 protein US12 Immediate-early protein IE12 Immediate-early-5 Infected cell protein 47 US12 protein Vmw12 protein protein hhv11 Human herpesvirus 1 (strain 17) (HHV-1) Human herpes simplex virus 1 HHV-1 MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPEIAPNASLGVAHRRTGGTVTDSPRNPVTR DIP protein P03170 original sequence version: 82 tap2_human Antigen peptide transporter 2 ATP-binding cassette sub-family B member 3 Peptide transporter TAP2 Peptide supply factor 2 Peptide transporter PSF2 Peptide transporter involved in antigen processing 2 TAP2 ABCB3 PSF2 RING11 Y1 Really interesting new gene 11 protein protein protein human Homo sapiens Human MRLPDLRPWTSLLLVDAALLWLLQGPLGTLLPQGLPGLWLEGTLRLGGLWGLLKLRGLLGFVGTLLLPLCLATPLTVSLRALVAGASRAPPARVASAPWSWLLVGYGAAGLSWSLWAVLSPPGAQEKEQDQVNNKVLMWRLLKLSRPDLPLLVAAFFFLVLAVLGETLIPHYSGRVIDILGGDFDPHAFASAIFFMCLFSFGSSLSAGCRGGCFTYTMSRINLRIREQLFSSLLRQDLGFFQETKTGELNSRLSSDTTLMSNWLPLNANVLLRSLVKVVGLYGFMLSISPRLTLLSLLHMPFTIAAEKVYNTRHQEVLREIQDAVARAGQVVREAVGGLQTVRSFGAEEHEVCRYKEALEQCRQLYWRRDLERALYLLVRRVLHLGVQMLMLSCGLQQMQDGELTQGSLLSFMIYQESVGSYVQTLVYIYGDMLSNVGAAEKVFSYMDRQPNLPSPGTLAPTTLQGVVKFQDVSFAYPNRPDRPVLKGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQVLLDEKPISQYEHCYLHSQVVSVGQEPVLFSGSVRNNIAYGLQSCEDDKVMAAAQAAHADDFIQEMEHGIYTDVGEKGSQLAAGQKQRLAIARALVRDPRVLILDEATSALDVQCEQALQDWNSRGDRTVLVIAHRLQTVQRAHQILVLQEGKLQKLAQL DIP protein Q03519 original sequence version: 123 DIP protein Q03519 original sequence version: 176 E7E4A7F6A2A3B48B tap1_human Antigen peptide transporter 1 ABCB2 PSF1 RING4 Y3 TAP1 Peptide transporter TAP1 ATP-binding cassette sub-family B member 2 Peptide supply factor 1 Peptide transporter PSF1 Peptide transporter involved in antigen processing 1 Really interesting new gene 4 protein protein protein human Homo sapiens Human MAELLASAGSACSWDFPRAPPSFPPPAASRGGLGGTRSFRPHRGAESPRPGRDRDGVRVPMASSRCPAPRGCRCLPGASLAWLGTVLLLLADWVLLRTALPRIFSLLVPTALPLLRVWAVGLSRWAVLWLGACGVLRATVGSKSENAGAQGWLAALKPLAAALGLALPGLALFRELISWGAPGSADSTRLLHWGSHPTAFVVSYAAALPAAALWHKLGSLWVPGGQGGSGNPVRRLLGCLGSETRRLSLFLVLVVLSSLGEMAIPFFTGRLTDWILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYNNTMGHVHSHLQGEVFGAVLRQETEFFQQNQTGNIMSRVTEDTSTLSDSLSENLSLFLWYLVRGLCLLGIMLWGSVSLTMVTLITLPLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTLNQKEAVAYAVNSWTTSISGMLLKVGILYIGGQLVTSGAVSSGNLVTFVLYQMQFTQAVEVLLSIYPRVQKAVGSSEKIFEYLDRTPRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDVLVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAAVGQEPQVFGRSLQENIAYGLTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGGQRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADHILFLEGGAIREGGTHQQLMEKKGCYWAMVQAPADAPE DIP protein Q03518 original sequence version: 123 DIP protein Q03518 original sequence version: 173 9CA5FF96FADD6A1B tap1-tap2-4 2 4 unspecified role unspecified role prey prey ecolx Escherichia coli 5 unspecified role unspecified role prey prey picpa Pichia pastoris (Yeast) Yeast Pichia pastoris 6 unspecified role unspecified role bait bait Protein-A-tag Protein-A-tag protein a tag protein a tag protein A protein A c-term range C-terminal range c-term range c-term range C-terminal range c-term range picpa Pichia pastoris (Yeast) Yeast Pichia pastoris association association tap1-tap2-5 3 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 5 unspecified role unspecified role unspecified role unspecified role picpa Pichia pastoris (Yeast) Yeast Pichia pastoris 6 unspecified role unspecified role unspecified role unspecified role picpa Pichia pastoris (Yeast) Yeast Pichia pastoris physical association physical association tap1-tap2-6 1 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 5 unspecified role unspecified role unspecified role unspecified role picpa Pichia pastoris (Yeast) Yeast Pichia pastoris 6 unspecified role unspecified role unspecified role unspecified role picpa Pichia pastoris (Yeast) Yeast Pichia pastoris physical association physical association