DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 2015 imex curation Shi J., Zhao Y., Wang K., Shi X., Wang Y., Huang H., Zhuang Y., Cai T., Wang F., Shao F. Only protein-protein interactions in vitro In vitro protease assay protease assay predetermined predetermined participant predetermined Shi J., Zhao Y., Wang K., Shi X., Wang Y., Huang H., Zhuang Y., Cai T., Wang F., Shao F. DIP original experiment: DIP-267075X Nature 2015 IMEx Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. Nature 2015 imex curation Shi J., Zhao Y., Wang K., Shi X., Wang Y., Huang H., Zhuang Y., Cai T., Wang F., Shao F. Only protein-protein interactions in vitro In vitro protease assay protease assay predetermined predetermined participant predetermined Shi J., Zhao Y., Wang K., Shi X., Wang Y., Huang H., Zhuang Y., Cai T., Wang F., Shao F. DIP original experiment: DIP-267074X Nature 2015 IMEx Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death. casp4_human Caspase-4 ICH2 CASP4 Protease TX ICE(rel)-II ICE and Ced-3 homolog 2 Mih1 protein protein human Homo sapiens Human MAEGNHRKKPLKVLESLGKDFLTGVLDNLVEQNVLNWKEEEKKKYYDAKTEDKVRVMADSMQEKQRMAGQMLLQTFFNIDQISPNKKAHPNMEAGPPESGESTDALKLCPHEEFLRLCKERAEEIYPIKERNNRTRLALIICNTEFDHLPPRNGADFDITGMKELLEGLDYSVDVEENLTARDMESALRAFATRPEHKSSDSTFLVLMSHGILEGICGTVHDEKKPDVLLYDTIFQIFNNRNCLSLKDKPKVIIVQACRGANRGELWVRDSPASLEVASSQSSENLEEDAVYKTHVEKDFIAFCSSTPHNVSWRDSTMGSIFITQLITCFQKYSWCCHLEEVFRKVQQSFETPRAKAQMPTIERLSMTRYFYLFPGN DIP protein P49662 original sequence version: 82 DIP protein P49662 original sequence version: 153 DC7CCEC6E9D483EB gsdmd_human Gasdermin-D DFNA5L GSDMDC1 Gasdermin domain-containing protein 1 FKSG10 GSDMD protein protein human Homo sapiens Human MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAAEPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLRQPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPSGSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAEGAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAGAVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERSTMSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH DIP protein P57764 original sequence version: 113 F7CE8073E0C0194D casp4_mouse Caspase-4 Casp4 Casp11 Caspl Ich3 Caspase-11 Protease ICH-3 protein protein mouse Mus musculus Mouse MAENKHPDKPLKVLEQLGKEVLTEYLEKLVQSNVLKLKEEDKQKFNNAERSDKRWVFVDAMKKKHSKVGEMLLQTFFSVDPGSHHGEANLEMEEPEESLNTLKLCSPEEFTRLCREKTQEIYPIKEANGRTRKALIICNTEFKHLSLRYGANFDIIGMKGLLEDLGYDVVVKEELTAEGMESEMKDFAALSEHQTSDSTFLVLMSHGTLHGICGTMHSEKTPDVLQYDTIYQIFNNCHCPGLRDKPKVIIVQACRGGNSGEMWIRESSKPQLCRGVDLPRNMEADAVKLSHVEKDFIAFYSTTPHHLSYRDKTGGSYFITRLISCFRKHACSCHLFDIFLKVQQSFEKASIHSQMPTIDRATLTRYFYLFPGN DIP protein P70343 original sequence version: 132 casp4-gsdmd-1 2 3 enzyme enzyme unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 4 enzyme target enzyme target substrate substrate unspecified role unspecified role ecolx Escherichia coli protein cleavage protein cleavage casp4-gsdmd-2 1 5 enzyme enzyme unspecified role unspecified role spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 4 enzyme target enzyme target substrate substrate unspecified role unspecified role ecolx Escherichia coli protein cleavage protein cleavage