IntAct European Bioinformatics Institute IntAct intact http://www.ebi.ac.uk/ http://www.ebi.ac.uk/intact/query/${ac} EBI-[0-9]+|IA:[0-9]+ INTerAction database (IntAct) provides an open source database and toolkit for the storage, presentation and analysis of molecular interactions. http://www.ebi.ac.uk/intact European Bioinformatics Institute; Wellcome Trust Genome Campus; Hinxton, Cambridge; CB10 1SD; United Kingdom http://www.ebi.ac.uk/intact/ Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Molecular cell 2015 imex curation Luo J., Cimermancic P., Viswanath S., Ebmeier CC., Kim B., Dehecq M., Raman V., Greenberg CH., Pellarin R., Sali A., Taatjes DJ., Hahn S., Ranish J. jranish@systemsbiology.org 14-Jul-2017: Contacted by IntAct-Help. Only protein-protein interactions yeast Saccharomyces cerevisiae Baker's yeast anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Luo J., Cimermancic P., Viswanath S., Ebmeier CC., Kim B., Dehecq M., Raman V., Greenberg CH., Pellarin R., Sali A., Taatjes DJ., Hahn S., Ranish J. I've largely gone with the summary in the text, rather than try and work out from the gel what the author has taken as 'real' or background binding. jranish@systemsbiology.org Accepted 2017-JUN-06 AT 07:49 BST AT 07:49 BST by MGT Molecular cell 2015 imex curation I agree XPD mentioned in text, but not shown on gel, and I can't find a description of the Ab to see if it recognised the XPB/XPD complex so have to assume not. Missing data added (fooled by mystery disappearance of Supp Table 7); Comment moved. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Molecular cell 2015 imex curation Luo J., Cimermancic P., Viswanath S., Ebmeier CC., Kim B., Dehecq M., Raman V., Greenberg CH., Pellarin R., Sali A., Taatjes DJ., Hahn S., Ranish J. jranish@systemsbiology.org 14-Jul-2017: Contacted by IntAct-Help. Only protein-protein interactions yeast Saccharomyces cerevisiae Baker's yeast anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Luo J., Cimermancic P., Viswanath S., Ebmeier CC., Kim B., Dehecq M., Raman V., Greenberg CH., Pellarin R., Sali A., Taatjes DJ., Hahn S., Ranish J. jranish@systemsbiology.org Accepted 2017-JUN-06 AT 07:49 BST AT 07:49 BST by MGT Molecular cell 2015 imex curation I agree XPD mentioned in text, but not shown on gel, and I can't find a description of the Ab to see if it recognised the XPB/XPD complex so have to assume not. Missing data added (fooled by mystery disappearance of Supp Table 7); Comment moved. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Molecular cell 2015 imex curation Luo J., Cimermancic P., Viswanath S., Ebmeier CC., Kim B., Dehecq M., Raman V., Greenberg CH., Pellarin R., Sali A., Taatjes DJ., Hahn S., Ranish J. jranish@systemsbiology.org 14-Jul-2017: Contacted by IntAct-Help. Only protein-protein interactions human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 anti tag coip anti tag coimmunoprecipitation anti tag coip sequence tag sequence tag identification sequence tag Luo J., Cimermancic P., Viswanath S., Ebmeier CC., Kim B., Dehecq M., Raman V., Greenberg CH., Pellarin R., Sali A., Taatjes DJ., Hahn S., Ranish J. jranish@systemsbiology.org Accepted 2017-JUN-06 AT 07:49 BST AT 07:49 BST by MGT Molecular cell 2015 imex curation I agree XPD mentioned in text, but not shown on gel, and I can't find a description of the Ab to see if it recognised the XPB/XPD complex so have to assume not. Missing data added (fooled by mystery disappearance of Supp Table 7); Comment moved. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Molecular cell 2015 imex curation Luo J., Cimermancic P., Viswanath S., Ebmeier CC., Kim B., Dehecq M., Raman V., Greenberg CH., Pellarin R., Sali A., Taatjes DJ., Hahn S., Ranish J. jranish@systemsbiology.org 14-Jul-2017: Contacted by IntAct-Help. Only protein-protein interactions in vitro In vitro crosslink cross-linking study crosslink sequence tag sequence tag identification sequence tag Luo J., Cimermancic P., Viswanath S., Ebmeier CC., Kim B., Dehecq M., Raman V., Greenberg CH., Pellarin R., Sali A., Taatjes DJ., Hahn S., Ranish J. A couple of the given residues did not map to a lysine or the N-terminal met so i haven't included those, as the linker seems specific. Its only 3 out of ~250 links. I have assumed the purification of both complexes is of the untagged version, based on the annotation of the gels in Supp Fig 1 as its not clear from the methods, and called the host organism in vitro as the xlinking happens post-purification. Affinnity purified yeast TFIIH or human TFIIH were crosslinked by addition of bis(sulfosuccinimidyl)suberate. Samples were digested with trypsin, and the resulting peptides were fractionated by SCX chromatography and analyzed by MS. jranish@systemsbiology.org Accepted 2017-JUN-06 AT 07:49 BST AT 07:49 BST by MGT Molecular cell 2015 imex curation I agree XPD mentioned in text, but not shown on gel, and I can't find a description of the Ab to see if it recognised the XPB/XPD complex so have to assume not. Missing data added (fooled by mystery disappearance of Supp Table 7); Comment moved. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Architecture of the Human and Yeast General Transcription and DNA Repair Factor TFIIH. Molecular cell 2015 imex curation Luo J., Cimermancic P., Viswanath S., Ebmeier CC., Kim B., Dehecq M., Raman V., Greenberg CH., Pellarin R., Sali A., Taatjes DJ., Hahn S., Ranish J. jranish@systemsbiology.org 14-Jul-2017: Contacted by IntAct-Help. Only protein-protein interactions human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Luo J., Cimermancic P., Viswanath S., Ebmeier CC., Kim B., Dehecq M., Raman V., Greenberg CH., Pellarin R., Sali A., Taatjes DJ., Hahn S., Ranish J. jranish@systemsbiology.org Accepted 2017-JUN-06 AT 07:49 BST AT 07:49 BST by MGT Molecular cell 2015 imex curation I agree XPD mentioned in text, but not shown on gel, and I can't find a description of the Ab to see if it recognised the XPB/XPD complex so have to assume not. Missing data added (fooled by mystery disappearance of Supp Table 7); Comment moved. rad25_yeast General transcription and DNA repair factor IIH helicase subunit XPB YIL143C SSL2 RAD25 UVS112 LOM3 Suppressor of stem-loop mutation 2 DNA repair helicase RAD25 RNA polymerase II transcription factor B subunit SSL2 protein protein yeast Saccharomyces cerevisiae Baker's yeast MTDVEGYQPKSKGKIFPDMGESFFSSDEDSPATDAEIDENYDDNRETSEGRGERDTGAMVTGLKKPRKKTKSSRHTAADSSMNQMDAKDKALLQDTNSDIPADFVPDSVSGMFRSHDFSYLRLRPDHASRPLWISPSDGRIILESFSPLAEQAQDFLVTIAEPISRPSHIHEYKITAYSLYAAVSVGLETDDIISVLDRLSKVPVAESIINFIKGATISYGKVKLVIKHNRYFVETTQADILQMLLNDSVIGPLRIDSDHQVQPPEDVLQQQLQQTAGKPATNVNPNDVEAVFSAVIGGDNEREEEDDDIDAVHSFEIANESVEVVKKRCQEIDYPVLEEYDFRNDHRNPDLDIDLKPSTQIRPYQEKSLSKMFGNGRARSGIIVLPCGAGKTLVGITAACTIKKSVIVLCTSSVSVMQWRQQFLQWCTLQPENCAVFTSDNKEMFQTESGLVVSTYSMVANTRNRSHDSQKVMDFLTGREWGFIILDEVHVVPAAMFRRVVSTIAAHAKLGLTATLVREDDKIGDLNFLIGPKLYEANWMELSQKGHIANVQCAEVWCPMTAEFYQEYLRETARKRMLLYIMNPTKFQACQFLIQYHERRGDKIIVFSDNVYALQEYALKMGKPFIYGSTPQQERMNILQNFQYNDQINTIFLSKVGDTSIDLPEATCLIQISSHYGSRRQEAQRLGRILRAKRRNDEGFNAFFYSLVSKDTQEMYYSTKRQAFLVDQGYAFKVITHLHGMENIPNLAYASPRERRELLQEVLLKNEEAAGIEVGDDADNSVGRGSNGHKRFKSKAVRGEGSLSGLAGGEDMAYMEYSTNKNKELKEHHPLIRKMYYKNLKK FA4013E8156FE1C5 FA4013E8156FE1C5 tfb4_yeast General transcription and DNA repair factor IIH subunit TFB4 RNA polymerase II transcription factor B p34 subunit RNA polymerase II transcription factor B 34 kDa subunit TFB4 RNA polymerase II transcription factor B subunit 4 YPR056W protein protein yeast Saccharomyces cerevisiae Baker's yeast MDAISDPTFKHARSRKQVTEESPSLLTVIIEIAPKLWTTFDEEGNEKGSIIKVLEALIVFLNAHLAFNSANKVAVIAAYSQGIKYLYPESTSALKASESENKTRSDLKIINSDMYRRFRNVDETLVEEIYKLFELEKKQIEQNSQRSTLAGAMSAGLTYVNRISKESVTTSLKSRLLVLTCGSGSSKDEIFQYIPIMNCIFSATKMKCPIDVVKIGGSKESTFLQQTTDATNGVYLHVESTEGLIQYLATAMFIDPSLRPIIVKPNHGSVDFRTSCYLTGRVVAVGFICSVCLCVLSIIPPGNKCPACDSQFDEHVIAKLKRKPVVPRLKAKKKVTKP B5C0CA95858453E0 B5C0CA95858453E0 ercc3_human General transcription and DNA repair factor IIH helicase subunit XPB ERCC3 XPB XPBC Basic transcription factor 2 89 kDa subunit TFIIH basal transcription factor complex 89 kDa subunit DNA repair protein complementing XP-B cells Xeroderma pigmentosum group B-complementing protein DNA excision repair protein ERCC-3 protein protein human Homo sapiens Human MGKRDRADRDKKKSRKRHYEDEEDDEEDAPGNDPQEAVPSAAGKQVDESGTKVDEYGAKDYRLQMPLKDDHTSRPLWVAPDGHIFLEAFSPVYKYAQDFLVAIAEPVCRPTHVHEYKLTAYSLYAAVSVGLQTSDITEYLRKLSKTGVPDGIMQFIKLCTVSYGKVKLVLKHNRYFVESCHPDVIQHLLQDPVIRECRLRNSEGEATELITETFTSKSAISKTAESSGGPSTSRVTDPQGKSDIPMDLFDFYEQMDKDEEEEEETQTVSFEVKQEMIEELQKRCIHLEYPLLAEYDFRNDSVNPDINIDLKPTAVLRPYQEKSLRKMFGNGRARSGVIVLPCGAGKSLVGVTAACTVRKRCLVLGNSAVSVEQWKAQFKMWSTIDDSQICRFTSDAKDKPIGCSVAISTYSMLGHTTKRSWEAERVMEWLKTQEWGLMILDEVHTIPAKMFRRVLTIVQAHCKLGLTATLVREDDKIVDLNFLIGPKLYEANWMELQNNGYIAKVQCAEVWCPMSPEFYREYVAIKTKKRILLYTMNPNKFRACQFLIKFHERRNDKIIVFADNVFALKEYAIRLNKPYIYGPTSQGERMQILQNFKHNPKINTIFISKVGDTSFDLPEANVLIQISSHGGSRRQEAQRLGRVLRAKKGMVAEEYNAFFYSLVSQDTQEMAYSTKRQRFLVDQGYSFKVITKLAGMEEEDLAFSTKEEQQQLLQKVLAATDLDAEEEVVAGEFGSRSSQASRRFGTMSSMSGADDTVYMEYHSSRSKAPSKHVHPLFKRFRK DIP protein P19447 original sequence version: 86 DIP protein P19447 original sequence version: 127 DIP protein P19447 original sequence version: 126 DIP protein P19447 original sequence version: 191 DIP protein P19447 original sequence version: 182 F5F4D3A89A7DF826 tf2h2_human General transcription factor IIH subunit 2 General transcription factor IIH polypeptide 2 TFIIH basal transcription factor complex p44 subunit Basic transcription factor 2 44 kDa subunit GTF2H2 BTF2P44 protein protein human Homo sapiens Human MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKKAVDMTCHGEPSLYNSLSIAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHVSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV DIP protein Q13888 original sequence version: 66 DIP protein Q13888 original sequence version: 109 DIP protein Q13888 original sequence version: 173 56D1BD8841288739 tfb3_yeast RNA polymerase II transcription factor B subunit 3 YDR460W RNA polymerase II transcription factor B 38 kDa subunit RNA polymerase II transcription factor B p38 subunit TFB3 RIG2 protein protein yeast Saccharomyces cerevisiae Baker's yeast MLMDEYEENKDMCPICKTDRYLSPDVKFLVNPECYHRICESCVDRIFSLGPAQCPYKGCDKILRKNKFKTQIFDDVEVEKEVDIRKRVFNVFNKTIDDFNGDLVEYNKYLEEVEDIIYKLDHGIDVAKTEEKLRTYEELNKQLIMNNLERSRTEIESFEQRQKFEKEMKLKKRLLERQIEEEERMNKEWTKKEIVNRLSTTTQDINETIEGVKNTVKLKKSSARRKLEELNRVLKNNPYFNSNVNVQNSRLKDAVPFTPFNGDREAHPRFTLKGSVYNDPFIKDLEHRKEFIASGFNTNYAYERVLTEAFMGLGCVISEEL 528D61CF25ADFAF4 528D61CF25ADFAF4 mat1_human CDK-activating kinase assembly factor MAT1 RING finger protein MAT1 Menage a trois CDK7/cyclin-H assembly factor p36 p35 Cyclin-G1-interacting protein RING finger protein 66 MNAT1 CAP35 MAT1 RNF66 protein protein human Homo sapiens Human MDDQGCPRCKTTKYRNPSLKLMVNVCGHTLCESCVDLLFVRGAGNCPECGTPLRKSNFRVQLFEDPTVDKEVEIRKKVLKIYNKREEDFPSLREYNDFLEEVEEIVFNLTNNVDLDNTKKKMEIYQKENKDVIQKNKLKLTREQEELEEALEVERQENEQRRLFIQKEEQLQQILKRKNKQAFLDELESSDLPVALLLAQHKDRSTQLEMQLEKPKPVKPVTFSTGIKMGQHISLAPIHKLEEALYEYQPLQIETYGPHVPELEMLGRLGYLNHVRAASPQDLAGGYTSSLACHRALQDAFSGLFWQPS 6818DDE230E81A97 ccnh_human Cyclin-H MO15-associated protein p37 p34 CCNH protein protein human Homo sapiens Human MYHNSSQKRHWTFSSEEQLARLRADANRKFRCKAVANGKVLPNDPVFLEPHEEMTLCKYYEKRLLEFCSVFKPAMPRSVVGTACMYFKRFYLNNSVMEYHPRIIMLTCAFLACKVDEFNVSSPQFVGNLRESPLGQEKALEQILEYELLLIQQLNFHLIVHNPYRPFEGFLIDLKTRYPILENPEILRKTADDFLNRIALTDAYLLYTPSQIALTAILSSASRAGITMESYLSESLMLKENRTCLSQLLDIMKSMRNLVKKYEPPRSEEVAVLKQKLERCHSAELALNVITKKRKGYEDDDYVSKKSKHEEEEWTDDDLVESL DIP protein P51946 original sequence version: 160 DIP protein P51946 original sequence version: 113 BB48D55DA397A0E4 rad3_yeast General transcription and DNA repair factor IIH helicase subunit XPD RAD3 REM1 DNA repair helicase RAD3 RNA polymerase II transcription factor B subunit RAD3 YER171W protein protein yeast Saccharomyces cerevisiae Baker's yeast MKFYIDDLPVLFPYPKIYPEQYNYMCDIKKTLDVGGNSILEMPSGTGKTVSLLSLTIAYQMHYPEHRKIIYCSRTMSEIEKALVELENLMDYRTKELGYQEDFRGLGLTSRKNLCLHPEVSKERKGTVVDEKCRRMTNGQAKRKLEEDPEANVELCEYHENLYNIEVEDYLPKGVFSFEKLLKYCEEKTLCPYFIVRRMISLCNIIIYSYHYLLDPKIAERVSNEVSKDSIVIFDEAHNIDNVCIESLSLDLTTDALRRATRGANALDERISEVRKVDSQKLQDEYEKLVQGLHSADILTDQEEPFVETPVLPQDLLTEAIPGNIRRAEHFVSFLKRLIEYLKTRMKVLHVISETPKSFLQHLKQLTFIERKPLRFCSERLSLLVRTLEVTEVEDFTALKDIATFATLISTYEEGFLLIIEPYEIENAAVPNPIMRFTCLDASIAIKPVFERFSSVIITSGTISPLDMYPRMLNFKTVLQKSYAMTLAKKSFLPMIITKGSDQVAISSRFEIRNDPSIVRNYGSMLVEFAKITPDGMVVFFPSYLYMESIVSMWQTMGILDEVWKHKLILVETPDAQETSLALETYRKACSNGRGAILLSVARGKVSEGIDFDHQYGRTVLMIGIPFQYTESRILKARLEFMRENYRIRENDFLSFDAMRHAAQCLGRVLRGKDDYGVMVLADRRFSRKRSQLPKWIAQGLSDADLNLSTDMAISNTKQFLRTMAQPTDPKDQEGVSVWSYEDLIKHQNSRKDQGGFIENENKEGEQDEDEDEDIEMQ 978BCA01751949B4 978BCA01751949B4 tf2h5_human General transcription factor IIH subunit 5 TFIIH subunit p8 GTF2H5 C6orf175 TTDA General transcription factor IIH polypeptide 5 TFB5 ortholog TFIIH basal transcription factor complex TTD-A subunit protein protein human Homo sapiens Human MVNVLKGVLIECDPAMKQFLLYLDESNALGKKFIIQDIDDTHVFVIAELVNVLQERVGELMDQNAFSLTQK DIP protein Q6ZYL4 original sequence version: 27 DIP protein Q6ZYL4 original sequence version: 65 DIP protein Q6ZYL4 original sequence version: 121 DBEB4D3C9BFA2C54 tf2h1_human General transcription factor IIH subunit 1 General transcription factor IIH polypeptide 1 TFIIH basal transcription factor complex p62 subunit Basic transcription factor 2 62 kDa subunit GTF2H1 BTF2 protein protein human Homo sapiens Human MATSSEEVLLIVKKVRQKKQDGALYLMAERIAWAPEGKDRFTISHMYADIKCQKISPEGKAKIQLQLVLHAGDTTNFHFSNESTAVKERDAVKDLLQQLLPKFKRKANKELEEKNRMLQEDPVLFQLYKDLVVSQVISAEEFWANRLNVNATDSSSTSNHKQDVGISAAFLADVRPQTDGCNGLRYNLTSDIIESIFRTYPAVKMKYAENVPHNMTEKEFWTRFFQSHYFHRDRLNTGSKDLFAECAKIDEKGLKTMVSLGVKNPLLDLTALEDKPLDEGYGISSVPSASNSKSIKENSNAAIIKRFNHHSAMVLAAGLRKQEAQNEQTSEPSNMDGNSGDADCFQPAVKRAKLQESIEYEDLGKNNSVKTIALNLKKSDRYYHGPTPIQSLQYATSQDIINSFQSIRQEMEAYTPKLTQVLSSSAASSTITALSPGGALMQGGTQQAINQMVPNDIQSELKHLYVAVGELLRHFWSCFPVNTPFLEEKVVKMKSNLERFQVTKLCPFQEKIRRQYLSTNLVSHIEEMLQTAYNKLHTWQSRRLMKKT DIP protein P32780 original sequence version: 70 DIP protein P32780 original sequence version: 97 DIP protein P32780 original sequence version: 95 DIP protein P32780 original sequence version: 120 DIP protein P32780-1 original sequence version: 151 8F0FCEBBB1FC9C1D ssl1_yeast General transcription and DNA repair factor IIH subunit SSL1 SSL1 RNA polymerase II transcription factor B subunit SSL1 Suppressor of stem-loop protein 1 YLR005W protein protein yeast Saccharomyces cerevisiae Baker's yeast MAPVVISESEEDEDRVAITRRTKRQVHFDGEGDDRVDQQQQQHSSSHRDRDKHVQRKKKKRLSNRNLQGSNGGYAWEDEIKRSWDLVKVDDEGDMASLVASIVEARKKRTAKKNITPYQRGIIRSLILTLDCSEAMLEKDLRPNRHAMIIQYAIDFVHEFFDQNPISQMGIIIMRNGLAQLVSQVSGNPQDHIDALKSIRKQEPKGNPSLQNALEMARGLLLPVPAHCTREVLIVFGSLSTTDPGDIHQTIDSLVSEKIRVKVLGLSAQVAICKELCKATNYGDESFYKILLDETHLKELFNEAVTPLPVNKINKGFTLVKMGFPTRIFEDTPTFCSCHSKLVYGGYFCPNCHSKVCSLPTVCPCCDLMLILSTHLARSYHHLMPLKTFAEVPTTEKFRSEDCFSCQSRFPILKNHKNGKLLTSSRYRCEDCKQEFCVDCDVFIHEILHNCPGCESKPVIT 57ADCB630B790B4F 57ADCB630B790B4F tf2h4_human General transcription factor IIH subunit 4 GTF2H4 Basic transcription factor 2 52 kDa subunit General transcription factor IIH polypeptide 4 TFIIH basal transcription factor complex p52 subunit protein protein human Homo sapiens Human MESTPSRGLNRVHLQCRNLQEFLGGLSPGVLDRLYGHPATCLAVFRELPSLAKNWVMRMLFLEQPLPQAAVALWVKKEFSKAQEESTGLLSGLRIWHTQLLPGGLQGLILNPIFRQNLRIALLGGGKAWSDDTSQLGPDKHARDVPSLDKYAEERWEVVLHFMVGSPSAAVSQDLAQLLSQAGLMKSTEPGEPPCITSAGFQFLLLDTPAQLWYFMLQYLQTAQSRGMDLVEILSFLFQLSFSTLGKDYSVEGMSDSLLNFLQHLREFGLVFQRKRKSRRYYPTRLAINLSSGVSGAGGTVHQPGFIVVETNYRLYAYTESELQIALIALFSEMLYRFPNMVVAQVTRESVQQAIASGITAQQIIHFLRTRAHPVMLKQTPVLPPTITDQIRLWELERDRLRFTEGVLYNQFLSQVDFELLLAHARELGVLVFENSAKRLMVVTPAGHSDVKRFWKRQKHSS DIP protein Q92759 original sequence version: 84 DIP protein Q92759 original sequence version: 149 5532DAD617CA743C yo352_yeast Uncharacterized protein YOR352W YOR352W protein protein yeast Saccharomyces cerevisiae Baker's yeast MSEPNTPLHAQPNEQLDLNNLNDLDEKDIDDLNLDPNSDVEISADSGDVVNSNIDNVIWQRNCNKKRRYHTPEFNDVYNETNNTINDVTMLDDVDDFQPRINVSSPFSSATKLSELLPNDHNGTSHPRRLSMSQQSKFISYVDDQLLQIQRKFVQSRGLNIKNGYASLTPLLQDLKTLVDFVWYSIAHVPNSDYLLQSEEKRHCPDSRNPKDTCGYSSYFGQGSYLIKIADDLIDYVEKFTFKNMEDSEINDTLSKLFKLFFILDRIFVILTDDNDNCKEVPKTSSASKNIAGLNGTDIVRLKGIAERTRVRLPIFLESQGIHGYHYELSKIYEGFLDHANSF E52A1C2DF5A5141A tfb2_yeast General transcription and DNA repair factor IIH subunit TFB2 RNA polymerase II transcription factor B subunit 2 YPL122C TFB2 RNA polymerase II transcription factor B p52 subunit RNA polymerase II transcription factor B 52 kDa subunit protein protein yeast Saccharomyces cerevisiae Baker's yeast MSDYSLKHSVTQYLEEIPQQVQNRLYTSPATCLAIYRILPPLAKFFIMAMVFNENEVPLLDLDKWVNSNGKLQFQNAIKSMKSLHLLIPNKSSGTLMINLNPTFKISLRNALTGGEVQNSFGVVVEENVVSLDLLDEYSANKWETILHFMVGTPLAKIPSEKVLNLLKHSKLMEEVNSTGEFKITNEGFQFLLQEINSQLWTLLLQYLKMIETSKMDLVDVLHFIFMLGALEVGKAYKIDALSETQRIMLQDMRDYGLVFQKHSNDSIFYPTKLALMLTSDTKTIRSASNAMDSVLRQNREEPSVNEDGANGKSTTDITTSDDLNKAGLKNQDIPDGSLIVETNFKIYSYSNSPLQIAVLSLFVHLKARFVNMVLGQITRESIRRALTNGITADQIIAYLETHAHPQMRRLAEEKLEKKLELDPNCKEPLQVLPPTVVDQIRLWQLELDRVITYEGSLYSDFETSQEYNLLSKYAQDIGVLLWKDDKKKKFFISKEGNSQVLDFAKRKLKKKQ 9E440B566396A95A 9E440B566396A95A t2h2l_human General transcription factor IIH subunit 2-like protein GTF2H2C GTF2H2C_2 GTF2H2D General transcription factor IIH polypeptide 2-like protein protein protein human Homo sapiens Human MDEEPERTKRWEGGYERTWEILKEDESGSLKATIEDILFKAKRKRVFEHHGQVRLGMMRHLYVVVDGSRTMEDQDLKPNRLTCTLKLLEYFVEEYFDQNPISQIGIIVTKSKRAEKLTELSGNPRKHITSLKEAVDMTCHGEPSLYNSLSMAMQTLKHMPGHTSREVLIIFSSLTTCDPSNIYDLIKTLKAAKIRVSVIGLSAEVRVCTVLARETGGTYHVILDESHYKELLTHHLSPPPASSSSECSLIRMGFPQHTIASLSDQDAKPSFSMAHLDGNTEPGLTLGGYFCPQCRAKYCELPVECKICGLTLVSAPHLARSYHHLFPLDAFQEIPLEEYNGERFCYGCQGELKDQHVYVCAVCQNVFCVDCDVFVHDSLHCCPGCIHKIPAPSGV mint homomint 3BBD377500E04B9A kin28_yeast Serine/threonine-protein kinase KIN28 D2330 YDL108W KIN28 protein protein yeast Saccharomyces cerevisiae Baker's yeast MKVNMEYTKEKKVGEGTYAVVYLGCQHSTGRKIAIKEIKTSEFKDGLDMSAIREVKYLQEMQHPNVIELIDIFMAYDNLNLVLEFLPTDLEVVIKDKSILFTPADIKAWMLMTLRGVYHCHRNFILHRDLKPNNLLFSPDGQIKVADFGLARAIPAPHEILTSNVVTRWYRAPELLFGAKHYTSAIDIWSVGVIFAELMLRIPYLPGQNDVDQMEVTFRALGTPTDRDWPEVSSFMTYNKLQIYPPPSRDELRKRFIAASEYALDFMCGMLTMNPQKRWTAVQCLESDYFKELPPPSDPSSIKIRN 763A5720A1D9ACF3 763A5720A1D9ACF3 tf2h3_human General transcription factor IIH subunit 3 GTF2H3 Basic transcription factor 2 34 kDa subunit General transcription factor IIH polypeptide 3 TFIIH basal transcription factor complex p34 subunit protein protein human Homo sapiens Human MVSDEDELNLLVIVVDANPIWWGKQALKESQFTLSKCIDAVMVLGNSHLFMNRSNKLAVIASHIQESRFLYPGKNGRLGDFFGDPGNPPEFNPSGSKDGKYELLTSANEVIVEEIKDLMTKSDIKGQHTETLLAGSLAKALCYIHRMNKEVKDNQEMKSRILVIKAAEDSALQYMNFMNVIFAAQKQNILIDACVLDSDSGLLQQACDITGGLYLKVPQMPSLLQYLLWVFLPDQDQRSQLILPPPVHVDYRAACFCHRNLIEIGYVCSVCLSIFCNFSPICTTCETAFKISLPPVLKAKKKKLKVSA DIP protein Q13889 original sequence version: 81 DIP protein Q13889 original sequence version: 145 E739E2176CD6BAA5 tfb5_yeast General transcription and DNA repair factor IIH subunit TFB5 TFB5 RNA polymerase II transcription factor B subunit 5 YDR079C-A protein protein yeast Saccharomyces cerevisiae Baker's yeast MARARKGALVQCDPSIKALILQIDAKMSDIVLEELDDTHLLVNPSKVEFVKHELNRLLSKNIYNPMDEEENQ 9198E5CCFF304239 9198E5CCFF304239 cdk7_human Cyclin-dependent kinase 7 CDK7 MO15 CAK CAK1 TFIIH basal transcription factor complex kinase subunit 39 kDa protein kinase CDKN7 STK1 Cell division protein kinase 7 CDK-activating kinase 1 Serine/threonine-protein kinase 1 protein protein human Homo sapiens Human MALDVKSRAKRYEKLDFLGEGQFATVYKARDKNTNQIVAIKKIKLGHRSEAKDGINRTALREIKLLQELSHPNIIGLLDAFGHKSNISLVFDFMETDLEVIIKDNSLVLTPSHIKAYMLMTLQGLEYLHQHWILHRDLKPNNLLLDENGVLKLADFGLAKSFGSPNRAYTHQVVTRWYRAPELLFGARMYGVGVDMWAVGCILAELLLRVPFLPGDSDLDQLTRIFETLGTPTEEQWPDMCSLPDYVTFKSFPGIPLHHIFSAAGDDLLDLIQGLFLFNPCARITATQALKMKYFSNRPGPTPGCQLPRPNCPVETLKEQSNPALAIKRKRTEALEQGGLPKKLIF DIP protein P50613 original sequence version: 126 DIP protein P50613 original sequence version: 78 0A94BFA7DD416CEB tfb1_yeast General transcription and DNA repair factor IIH subunit TFB1 TFB1 RNA polymerase II transcription factor B p73 subunit RNA polymerase II transcription factor B 73 kDa subunit RNA polymerase II transcription factor B subunit 1 D9740.3 YDR311W protein protein yeast Saccharomyces cerevisiae Baker's yeast MSHSGAAIFEKVSGIIAINEDVSPAELTWRSTDGDKVHTVVLSTIDKLQATPASSEKMMLRLIGKVDESKKRKDNEGNEVVPKPQRHMFSFNNRTVMDNIKMTLQQIISRYKDADIYEEKRRREESAQHTETPMSSSSVTAGTPTPHLDTPQLNNGAPLINTAKLDDSLSKEKLLTNLKLQQSLLKGNKVLMKVFQETVINAGLPPSEFWSTRIPLLRAFALSTSQKVGPYNVLSTIKPVASSENKVNVNLSREKILNIFENYPIVKKAYTDNVPKNFKEPEFWARFFSSKLFRKLRGEKIMQNDRGDVIIDRYLTLDQEFDRKDDDMLLHPVKKIIDLDGNIQDDPVVRGNRPDFTMQPGVDINGNSDGTVDILKGMNRLSEKMIMALKNEYSRTNLQNKSNITNDEEDEDNDERNELKIDDLNESYKTNYAIIHLKRNAHEKTTDNDAKSSADSIKNADLKVSNQQMLQQLSLVMDNLINKLDLNQVVPNNEVSNKINKRVITAIKINAKQAKHNNVNSALGSFVDNTSQANELEVKSTLPIDLLESCRMLHTTCCEFLKHFYIHFQSGEQKQASTVKKLYNHLKDCIEKLNELFQDVLNGDGESMSNTCTAYLKPVLNSITLATHKYDEYFNEYNNNSN DAE369FE90A224F8 DAE369FE90A224F8 ercc2_human General transcription and DNA repair factor IIH helicase subunit XPD ERCC2 XPD XPDC Basic transcription factor 2 80 kDa subunit CXPD DNA excision repair protein ERCC-2 DNA repair protein complementing XP-D cells TFIIH basal transcription factor complex 80 kDa subunit Xeroderma pigmentosum group D-complementing protein protein protein human Homo sapiens Human MKLNVDGLLVYFPYDYIYPEQFSYMRELKRTLDAKGHGVLEMPSGTGKTVSLLALIMAYQRAYPLEVTKLIYCSRTVPEIEKVIEELRKLLNFYEKQEGEKLPFLGLALSSRKNLCIHPEVTPLRFGKDVDGKCHSLTASYVRAQYQHDTSLPHCRFYEEFDAHGREVPLPAGIYNLDDLKALGRRQGWCPYFLARYSILHANVVVYSYHYLLDPKIADLVSKELARKAVVVFDEAHNIDNVCIDSMSVNLTRRTLDRCQGNLETLQKTVLRIKETDEQRLRDEYRRLVEGLREASAARETDAHLANPVLPDEVLQEAVPGSIRTAEHFLGFLRRLLEYVKWRLRVQHVVQESPPAFLSGLAQRVCIQRKPLRFCAERLRSLLHTLEITDLADFSPLTLLANFATLVSTYAKGFTIIIEPFDDRTPTIANPILHFSCMDASLAIKPVFERFQSVIITSGTLSPLDIYPKILDFHPVTMATFTMTLARVCLCPMIIGRGNDQVAISSKFETREDIAVIRNYGNLLLEMSAVVPDGIVAFFTSYQYMESTVASWYEQGILENIQRNKLLFIETQDGAETSVALEKYQEACENGRGAILLSVARGKVSEGIDFVHHYGRAVIMFGVPYVYTQSRILKARLEYLRDQFQIRENDFLTFDAMRHAAQCVGRAIRGKTDYGLMVFADKRFARGDKRGKLPRWIQEHLTDANLNLTVDEGVQVAKYFLRQMAQPFHREDQLGLSLLSLEQLESEETLKRIEQIAQQL DIP protein P18074 original sequence version: 90 DIP protein P18074 original sequence version: 132 DIP protein P18074 original sequence version: 198 746C0888CDF2E331 ccl1_yeast Cyclin CCL1 CCL1 YP9367.05C YPR025C protein protein yeast Saccharomyces cerevisiae Baker's yeast MTDIQLNGKSTLDTPSATMSAKEKEAKLKSADENNKPPNYKRISDDDLYRHSSQYRMWSYTKDQLQEKRVDTNARAIAYIEENLLKFREAHNLTEEEIKVLEAKAIPLTMEEELDLVNFYAKKVQVIAQHLNLPTEVVATAISFFRRFFLENSVMQIDPKSIVHTTIFLACKSENYFISVDSFAQKAKSTRDSVLKFEFKLLESLKFSLLNHHPYKPLHGFFLDIQNVLYGKVDLNYMGQIYDRCKKRITAALLTDVVYFYTPPQITLATLLIEDEALVTRYLETKFPSREGSQESVPGNEKEEPQNDASTTEKNKEKSTESEEYSIDSAKLLTIIRECKSIIEDCKPPSTEEAKKIAAKNYYCQNPSTLIQKLKRKLNGEDTSSTVEKKQKT FE06E78FC38A8433 FE06E78FC38A8433 kin28-rad3-1 4 10 unspecified role unspecified role neutral component neutral component lys-235 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-235 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-10 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-17 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-235 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-235 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain met-1 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-163 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-226 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-192 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-219 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-171 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain met-1 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-10 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain met-1 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-235 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-235 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-235 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain met-1 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-213 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-235 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-226 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-171 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-235 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-226 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-289 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 18 unspecified role unspecified role neutral component neutral component lys-289 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-162 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 23 unspecified role unspecified role neutral component neutral component lys-6 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-60 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-6 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-6 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-6 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 7 unspecified role unspecified role neutral component neutral component lys-16 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-102 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-95 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-323 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-108 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-95 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-323 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-102 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-173 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-207 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-323 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-319 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-173 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-102 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-173 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-108 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-187 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-323 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-323 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-187 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-323 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-187 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-102 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-108 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-207 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 19 unspecified role unspecified role neutral component neutral component lys-418 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-427 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-415 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-313 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-415 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-415 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-313 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-419 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-238 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-238 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-427 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-427 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-427 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-427 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-238 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-238 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-506 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-495 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 16 unspecified role unspecified role neutral component neutral component lys-201 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-201 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-201 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-397 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-197 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-112 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-113 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-397 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-397 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-397 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-414 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-321 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-197 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-197 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-88 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-315 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-414 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-201 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-205 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-112 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-201 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-201 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-387 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-113 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-113 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-205 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-205 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-457 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-201 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 21 unspecified role unspecified role neutral component neutral component lys-44 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-32 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-303 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-303 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-303 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-240 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 25 unspecified role unspecified role neutral component neutral component lys-238 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-483 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-444 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-401 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-390 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-335 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-420 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-101 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-438 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-238 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-444 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-120 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-120 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-458 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-83 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-451 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-291 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-291 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-101 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-120 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-335 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-73 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-376 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-120 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-438 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-120 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-101 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-438 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-444 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-246 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-255 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-438 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 13 unspecified role unspecified role neutral component neutral component region tap tagged calmodulin binding peptide plus protein a tag CBP-ProtA tagged CBP-ProtA tagged tap tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined lys-476 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-752 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-125 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-125 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-2 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-588 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-364 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-276 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-2 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-490 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-731 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-731 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-499 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-689 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-588 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-588 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-588 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-95 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-95 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-357 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-125 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-30 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-499 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-490 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-499 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-112 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-125 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-125 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-125 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-636 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 6 unspecified role unspecified role neutral component neutral component lys-734 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-357 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-721 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-228 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-214 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-357 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-279 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-228 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-523 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-64 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-228 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-12 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-372 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 27 unspecified role unspecified role neutral component neutral component lys-196 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-247 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-29 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-24 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain yeast Saccharomyces cerevisiae Baker's yeast 30 192 31 211 32 212 33 194 34 197 35 198 36 199 228 37 38 229 39 230 40 231 41 232 42 176 43 174 44 175 239 45 240 46 221 47 48 195 49 148 50 149 152 51 52 153 53 154 155 54 55 156 226 57 58 227 60 66 61 225 147 62 108 63 109 64 67 124 68 125 69 169 70 126 127 71 128 72 73 129 130 74 75 131 76 132 133 77 100 78 101 79 102 80 81 159 82 168 83 160 84 170 171 85 172 86 87 173 106 88 107 89 103 90 111 92 112 93 113 94 114 95 115 96 223 97 135 98 99 136 104 215 105 216 200 116 117 201 196 118 193 119 120 202 121 203 122 204 123 205 134 233 167 137 138 182 139 183 140 184 141 185 186 142 143 166 187 144 145 188 146 189 151 237 224 158 161 206 162 207 163 208 209 164 165 210 238 177 217 178 179 218 219 180 220 181 234 213 214 235 physical association physical association Supp. Fig. 1, Supp Table 1 ccnh-cdk7-1 4 14 unspecified role unspecified role neutral component neutral component lys-31 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-6 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-71 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-6 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-71 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-71 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-71 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-71 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-6 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 17 unspecified role unspecified role neutral component neutral component lys-438 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-378 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-378 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-378 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-140 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-277 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-53 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-452 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-77 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-378 biological feature biological feature certain certain sequence position certain certain certain sequence position certain lys-378 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-127 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-378 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-378 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-77 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-378 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-438 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-456 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 22 unspecified role unspecified role neutral component neutral component lys-149 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-125 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-125 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-149 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-152 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-97 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-149 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-149 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-149 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-152 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 15 unspecified role unspecified role neutral component neutral component lys-161 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-353 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-293 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-296 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-378 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-38 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-38 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-353 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-38 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-252 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-161 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-365 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-353 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-353 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-350 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-350 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-275 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-293 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 9 unspecified role unspecified role neutral component neutral component lys-116 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-126 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-40 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-126 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-126 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-31 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-126 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-42 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-229 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-229 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-23 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-31 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-23 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-40 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-268 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-77 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 11 unspecified role unspecified role neutral component neutral component lys-55 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-121 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-180 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-202 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-176 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-167 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-167 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-167 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-167 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-167 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 12 unspecified role unspecified role neutral component neutral component lys-239 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-293 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 24 unspecified role unspecified role neutral component neutral component lys-52 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-293 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 8 unspecified role unspecified role neutral component neutral component lys-44 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-171 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-142 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-526 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-706 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-526 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-241 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-257 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-379 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-222 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-326 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-171 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-171 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-549 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-171 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-217 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-222 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-257 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-142 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-142 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-767 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-526 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-59 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-476 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-167 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 26 unspecified role unspecified role neutral component neutral component lys-603 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-113 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-603 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-29 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-101 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-682 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-682 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-682 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-682 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-507 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-96 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-603 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-113 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-82 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-113 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-82 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-603 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-689 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-634 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain lys-634 cross linker cross linker crosslinker crosslinker certain certain sequence position certain certain certain sequence position certain human-hela Homo sapiens epitheloid cervix carcinoma cells Human hela Human epitheloid cervix carcinoma HeLa cells derivation: cervix; epithelial; adenocarcinoma ATCC no:CCL-2 243 259 260 244 245 261 246 270 247 356 357 248 358 249 250 359 360 251 253 340 341 254 342 255 256 343 257 365 366 258 275 262 263 276 264 277 265 314 266 315 316 267 317 268 269 339 304 272 287 273 288 274 278 303 309 279 310 280 311 281 283 302 374 284 363 285 286 364 349 289 305 290 306 291 292 307 293 308 294 372 295 373 377 296 375 297 376 298 378 299 362 300 354 312 313 355 319 330 320 336 337 321 322 338 350 323 324 351 325 352 326 353 379 327 380 328 331 333 381 334 344 367 368 345 346 369 347 370 371 348 physical association physical association Supp Fig. 1, Supp Table 1 tfb1-kin28-1 1 7 unspecified role unspecified role prey prey 10 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain 16 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 6 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey association association Fig. 5A, 5B, Supp Fig. 7A tfb1-ssl1-4 1 7 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait bsd domain region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain 16 unspecified role unspecified role prey prey association association Fig. 5A, 5B, Supp Fig. 7A Deletions that remove the BSD1 or BSD2 domains (delta5–7, 173-288) all showed significant reductions in association with Rad3, Tfb3, Ssl2 and Kin28. tfb1-ssl1-3 1 25 unspecified role unspecified role bait bait region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain 16 unspecified role unspecified role prey prey 7 unspecified role unspecified role prey prey association association Fig. 5A, 5B, Supp Fig. 7A Deletions that remove the BSD1 or BSD2 domains (delta5–7, 368-491) all showed significant reductions in association with Rad3, Tfb3, Ssl2 and Kin28;Delta 9,10 shows an additional defect in association with Tfb2 tfb1-kin28-2 1 10 unspecified role unspecified role prey prey 25 unspecified role unspecified role bait bait region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain 13 unspecified role unspecified role prey prey 6 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey association association Fig. 5A, 5B, Supp Fig. 7A Deletion of the Tfb1 3-helix bundle C-terminus (368-642) is defective in interactions with Tfb2, Ssl1, and Tfb4. ercc3-gtf2h1-1 5 15 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region required to bind necessary binding region required to bind certain certain sequence position certain certain certain sequence position certain 8 unspecified role unspecified role prey prey 26 unspecified role unspecified role prey prey association association Fig. 5C tfb1-ccl1-5 2 23 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 10 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 6 unspecified role unspecified role prey prey 21 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey association association Supp Fig. 7B tfb4-ccl1-1 2 21 unspecified role unspecified role prey prey 7 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined 10 unspecified role unspecified role prey prey 19 unspecified role unspecified role prey prey 25 unspecified role unspecified role prey prey 16 unspecified role unspecified role prey prey 13 unspecified role unspecified role prey prey 27 unspecified role unspecified role prey prey 6 unspecified role unspecified role prey prey association association Supp Fig. 7B Interaction observed in TFB5 -/- cells. SSL2 levels are significantly lower in the absence of TFB5 compared to the other subunits gtf2h1-ccnh-1 3 20 unspecified role unspecified role prey prey 17 unspecified role unspecified role prey prey 22 unspecified role unspecified role prey prey 11 unspecified role unspecified role prey prey 15 unspecified role unspecified role bait bait region flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined region sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain 12 unspecified role unspecified role prey prey 24 unspecified role unspecified role prey prey physical association physical association Supp Table 7