DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure (London, England : 1993) 2015 imex curation Lu YC., Nazarko OV., Sando R., Salzman GS., Südhof TC., Araç D. Only protein-protein interactions in vitro In vitro bio-layer interferometry bio-layer interferometry bli bli predetermined predetermined participant predetermined Lu YC., Nazarko OV., Sando R., Salzman GS., Südhof TC., Araç D. DIP original experiment: DIP-267233X Structure (London, England : 1993) 2015 IMEx Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure (London, England : 1993) 2015 imex curation Lu YC., Nazarko OV., Sando R., Salzman GS., Südhof TC., Araç D. Only protein-protein interactions in vitro In vitro bio-layer interferometry bio-layer interferometry bli bli predetermined predetermined participant predetermined Lu YC., Nazarko OV., Sando R., Salzman GS., Südhof TC., Araç D. DIP original experiment: DIP-267232X Structure (London, England : 1993) 2015 IMEx Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure (London, England : 1993) 2015 imex curation Lu YC., Nazarko OV., Sando R., Salzman GS., Südhof TC., Araç D. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Lu YC., Nazarko OV., Sando R., Salzman GS., Südhof TC., Araç D. DIP original experiment: DIP-267230X Structure (London, England : 1993) 2015 IMEx Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure (London, England : 1993) 2015 imex curation Lu YC., Nazarko OV., Sando R., Salzman GS., Südhof TC., Araç D. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Lu YC., Nazarko OV., Sando R., Salzman GS., Südhof TC., Araç D. DIP original experiment: DIP-267231X Structure (London, England : 1993) 2015 IMEx Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. Structure (London, England : 1993) 2015 imex curation Lu YC., Nazarko OV., Sando R., Salzman GS., Südhof TC., Araç D. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Lu YC., Nazarko OV., Sando R., Salzman GS., Südhof TC., Araç D. DIP original experiment: DIP-267234X Structure (London, England : 1993) 2015 IMEx Structural Basis of Latrophilin-FLRT-UNC5 Interaction in Cell Adhesion. flrt3_human Leucine-rich repeat transmembrane protein FLRT3 FLRT3 KIAA1469 UNQ856/PRO1865 Fibronectin-like domain-containing leucine-rich transmembrane protein 3 protein protein human Homo sapiens Human MISAAWSIFLIGTKIGLFLQVAPLSVMAKSCPSVCRCDAGFIYCNDRFLTSIPTGIPEDATTLYLQNNQINNAGIPSDLKNLLKVERIYLYHNSLDEFPTNLPKYVKELHLQENNIRTITYDSLSKIPYLEELHLDDNSVSAVSIEEGAFRDSNYLRLLFLSRNHLSTIPWGLPRTIEELRLDDNRISTISSPSLQGLTSLKRLVLDGNLLNNHGLGDKVFFNLVNLTELSLVRNSLTAAPVNLPGTNLRKLYLQDNHINRVPPNAFSYLRQLYRLDMSNNNLSNLPQGIFDDLDNITQLILRNNPWYCGCKMKWVRDWLQSLPVKVNVRGLMCQAPEKVRGMAIKDLNAELFDCKDSGIVSTIQITTAIPNTVYPAQGQWPAPVTKQPDIKNPKLTKDHQTTGSPSRKTITITVKSVTSDTIHISWKLALPMTALRLSWLKLGHSPAFGSITETIVTGERSEYLVTALEPDSPYKVCMVPMETSNLYLFDETPVCIETETAPLRMYNPTTTLNREQEKEPYKNPNLPLAAIIGGAVALVTIALLALVCWYVHRNGSLFSRNCAYSKGRRRKDDYAEAGTKKDNSILEIRETSFQMLPISNEPISKEEFVIHTIFPPNGMNLYKNNHSESSSNRSYRDSGIPDSDHSHS DIP protein Q9NZU0 original sequence version: 143 9EFF666C46181F08 agrl3_human Adhesion G protein-coupled receptor L3 ADGRL3 Calcium-independent alpha-latrotoxin receptor 3 KIAA0768 LEC3 LPHN3 Latrophilin-3 Lectomedin-3 protein protein human Homo sapiens Human MWPSQLLIFMMLLAPIIHAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGQAHHGQVSYISPPIHLDSELERPSVKDISTTGPLGMGSTTTSTTLRTTTLSPGRSTTPSVSGRRNRSTSTPSPAVEVLDDMTTHLPSASSQIPALEESCEAVEAREIMWFKTRQGQIAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLTPGGKDSAARSLNKAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLHTVEESAFVLADNLLKTDIVRENTDNIKLEVARLSTEGNLEDLKFPENMGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEALSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLNGNHGNSYSIASGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQNRNLMNKLVNNLGSGREDDAIVLDDATSFNHEESLGLELIHEESDAPLLPPRVYSTENHQPHHYTRRRIPQDHSESFFPLLTNEHTEDLQSPHRDSLYTSMPTLAGVAATESVTTSTQTEPPPAKCGDAEDVYYKSMPNLGSRNHVHQLHTYYQLGRGSSDGFIVPPNKDGTPPEGSSKGPAHLVTSL DIP protein Q9HAR2 original sequence version: 117 54B7E7DBE516447A flrt3-adgrl3-1 2 7 unspecified role unspecified role prey prey Region 132-392 Region 132-392 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper 6 unspecified role unspecified role bait bait Region 29-357 Region 29-357 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction adgrl3-flrt3-1 3 7 unspecified role unspecified role unspecified role unspecified role Region 132-392 Region 132-392 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper 6 unspecified role unspecified role unspecified role unspecified role Region 29-357 Region 29-357 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction flrt3-1 5 6 unspecified role unspecified role unspecified role unspecified role Region 29-357 Region 29-357 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q9NZU0:p.[Arg181Asn;Asp183Thr] R181N/D183T mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain D T certain certain sequence position certain certain certain sequence position certain R N This feature has been corrected as a result of our quality control procedures. The original label was 'R181N/D183T'. Wed May 02 19:40:05 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg181asn,asp183thr' Tue Jun 30 18:49:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg181Asn;Asp183Thr]' trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction adgrl3-flrt3-2 1 7 unspecified role unspecified role bait bait Region 132-392 Region 132-392 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper 6 unspecified role unspecified role prey prey Region 29-357 Region 29-357 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction adgrl3-flrt3-3 4 7 unspecified role unspecified role unspecified role unspecified role Region 132-392 Region 132-392 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper 6 unspecified role unspecified role unspecified role unspecified role Region 29-357 Region 29-357 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction