DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 2015 imex curation Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. DIP original experiment: DIP-265979X Nature 2015 IMEx Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 2015 imex curation Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. DIP original experiment: DIP-265976X Nature 2015 IMEx Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 2015 imex curation Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. DIP original experiment: DIP-265977X Nature 2015 IMEx Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. Nature 2015 imex curation Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. Only protein-protein interactions human Homo sapiens Human pull down pull down predetermined predetermined participant predetermined Krönke J., Fink EC., Hollenbach PW., MacBeth KJ., Hurst SN., Udeshi ND., Chamberlain PP., Mani DR., Man HW., Gandhi AK., Svinkina T., Schneider RK., McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE., Carr SA., Chopra R., Ebert BL. DIP original experiment: DIP-265978X Nature 2015 IMEx Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS. ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG ddb1_human DNA damage-binding protein 1 DDB1 Damage-specific DNA-binding protein 1 UV-damaged DNA-binding factor DDB p127 subunit DNA damage-binding protein a UV-damaged DNA-binding protein 1 Xeroderma pigmentosum group E-complementing protein XPE-binding factor HBV X-associated protein 1 XAP1 protein protein human Homo sapiens Human MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH DIP protein Q16531 original sequence version: 145 DIP protein Q16531 original sequence version: 140 DIP protein Q16531 original sequence version: 99 DIP protein Q16531 original sequence version: 93 DIP protein Q16531 original sequence version: 116 DIP protein Q16531 original sequence version: 111 DIP protein Q16531-1 original sequence version: 163 DIP protein Q16531 original sequence version: 162 DIP protein Q16531 original sequence version: 113 DIP protein Q16531 original sequence version: 132 DIP protein Q16531 original sequence version: 139 DIP protein Q16531 original sequence version: 151 DIP protein Q16531-1 original sequence version: 144 DIP protein Q16531 original sequence version: 155 74D082023E3D846D crbn_human Protein cereblon CRBN AD-006 protein protein human Homo sapiens Human MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL DIP protein Q96SW2 original sequence version: 125 DIP protein Q96SW2 original sequence version: 124 DIP protein Q96SW2 original sequence version: 113 DIP protein Q96SW2-1 original sequence version: 107 DIP protein Q96SW2 original sequence version: 117 90DF77D98A8BEAA8 kc1a_human Casein kinase I isoform alpha CSNK1A1 CK1 protein protein human Homo sapiens Human MASSSGSKAEFIVGGKYKLVRKIGSGSFGDIYLAINITNGEEVAVKLESQKARHPQLLYESKLYKILQGGVGIPHIRWYGQEKDYNVLVMDLLGPSLEDLFNFCSRRFTMKTVLMLADQMISRIEYVHTKNFIHRDIKPDNFLMGIGRHCNKLFLIDFGLAKKYRDNRTRQHIPYREDKNLTGTARYASINAHLGIEQSRRDDMESLGYVLMYFNRTSLPWQGLKAATKKQKYEKISEKKMSTPVEVLCKGFPAEFAMYLNYCRGLRFEEAPDYMYLRQLFRILFRTLNHQYDYTFDWTMLKQKAAQQAASSSGQGQQAQTPTGKQTDKTKSNMKGF DIP protein P48729 original sequence version: 92 DIP protein P48729 original sequence version: 171 DIP protein P48729 original sequence version: 163 1B2085AE33CAFAC2 crbn-csnk1a1-2 2 6 unspecified role unspecified role prey prey human Homo sapiens Human 8 unspecified role unspecified role prey prey human Homo sapiens Human 7 unspecified role unspecified role bait bait human Homo sapiens Human association association crbn-csnk1a1-3 1 8 unspecified role unspecified role prey prey human Homo sapiens Human 7 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association crbn-ddb1-6 3 6 unspecified role unspecified role prey prey human Homo sapiens Human 7 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association ub-csnk1a1-1 4 5 unspecified role unspecified role bait bait human Homo sapiens Human 8 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association