DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature 2015 imex curation Mbengue A., Bhattacharjee S., Pandharkar T., Liu H., Estiu G., Stahelin RV., Rizk SS., Njimoh DL., Ryan Y., Chotivanich K., Nguon C., Ghorbal M., Lopez-Rubio JJ., Pfrender M., Emrich S., Mohandas N., Dondorp AM., Wiest O., Haldar K. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mbengue A., Bhattacharjee S., Pandharkar T., Liu H., Estiu G., Stahelin RV., Rizk SS., Njimoh DL., Ryan Y., Chotivanich K., Nguon C., Ghorbal M., Lopez-Rubio JJ., Pfrender M., Emrich S., Mohandas N., Dondorp AM., Wiest O., Haldar K. DIP original experiment: DIP-265490X Nature 2015 IMEx A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature 2015 imex curation Mbengue A., Bhattacharjee S., Pandharkar T., Liu H., Estiu G., Stahelin RV., Rizk SS., Njimoh DL., Ryan Y., Chotivanich K., Nguon C., Ghorbal M., Lopez-Rubio JJ., Pfrender M., Emrich S., Mohandas N., Dondorp AM., Wiest O., Haldar K. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Mbengue A., Bhattacharjee S., Pandharkar T., Liu H., Estiu G., Stahelin RV., Rizk SS., Njimoh DL., Ryan Y., Chotivanich K., Nguon C., Ghorbal M., Lopez-Rubio JJ., Pfrender M., Emrich S., Mohandas N., Dondorp AM., Wiest O., Haldar K. DIP original experiment: DIP-265492X Nature 2015 IMEx A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature 2015 imex curation Mbengue A., Bhattacharjee S., Pandharkar T., Liu H., Estiu G., Stahelin RV., Rizk SS., Njimoh DL., Ryan Y., Chotivanich K., Nguon C., Ghorbal M., Lopez-Rubio JJ., Pfrender M., Emrich S., Mohandas N., Dondorp AM., Wiest O., Haldar K. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Mbengue A., Bhattacharjee S., Pandharkar T., Liu H., Estiu G., Stahelin RV., Rizk SS., Njimoh DL., Ryan Y., Chotivanich K., Nguon C., Ghorbal M., Lopez-Rubio JJ., Pfrender M., Emrich S., Mohandas N., Dondorp AM., Wiest O., Haldar K. DIP original experiment: DIP-265489X Nature 2015 IMEx A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature 2015 imex curation Mbengue A., Bhattacharjee S., Pandharkar T., Liu H., Estiu G., Stahelin RV., Rizk SS., Njimoh DL., Ryan Y., Chotivanich K., Nguon C., Ghorbal M., Lopez-Rubio JJ., Pfrender M., Emrich S., Mohandas N., Dondorp AM., Wiest O., Haldar K. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Mbengue A., Bhattacharjee S., Pandharkar T., Liu H., Estiu G., Stahelin RV., Rizk SS., Njimoh DL., Ryan Y., Chotivanich K., Nguon C., Ghorbal M., Lopez-Rubio JJ., Pfrender M., Emrich S., Mohandas N., Dondorp AM., Wiest O., Haldar K. DIP original experiment: DIP-265491X Nature 2015 IMEx A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. q8idq2_plaf7 PF3D7_1343700 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MEGEKVKTKANSISNFSMTYDRESGGNSNSDDKSGSSSENDSNSFMNLTSDKNEKTENNSFLLNNSSYGNVKDSLLESIDMSVLDSNFDSKKDFLPSNLSRTFNNMSKDNIGNKYLNKLLNKKKDTITNENNNINHNNNNNNLTANNITNNLINNNMNSPSIMNTNKKENFLDAANLINDDSGLNNLKKFSTVNNVNDTYEKKIIETELSDASDFENMVGDLRITFINWLKKTQMNFIREKDKLFKDKKELEMERVRLYKELENRKNIEEQKLHDERKKLDIDISNGYKQIKKEKEEHRKRFDEERLRFLQEIDKIKLVLYLEKEKYYQEYKNFENDKKKIVDANIATETMIDINVGGAIFETSRHTLTQQKDSFIEKLLSGRHHVTRDKQGRIFLDRDSELFRIILNFLRNPLTIPIPKDLSESEALLKEAEFYGIKFLPFPLVFCIGGFDGVEYLNSMELLDISQQCWRMCTPMSTKKAYFGSAVLNNFLYVFGGNNYDYKALFETEVYDRLRDVWYVSSNLNIPRRNNCGVTSNGRIYCIGGYDGSSIIPNVEAYDHRMKAWVEVAPLNTPRSSAMCVAFDNKIYVIGGTNGERLNSIEVYEEKMNKWEQFPYALLEARSSGAAFNYLNQIYVVGGIDNEHNILDSVEQYQPFNKRWQFLNGVPEKKMNFGAATLSDSYIITGGENGEVLNSCHFFSPDTNEWQLGPSLLVPRFGHSVLIANI DIP protein Q8IDQ2 original sequence version: 75 ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG q8i3v5_plaf7 PF3D7_0515300 protein protein plaf7 Plasmodium falciparum (isolate 3D7) MKIRYDKCSSTKDLNYFFHLKLGFFVCYKNHNDKYSFKNKILQKNDTILFFKKKKKFMYLRKKKKKKKKKILIQIIQEYNKYNEYFKYNSNLEGNQGFNKKPEKNKNTKGNVYTDHTNQNAKSKIYNYDMNDDSYSNYVNNNNVFRISSFLILNNEFFGYPLQFVCETEGRSRNHEHYPDVHGDNIKYNKCDDNKYNKCDDNKYDKCDDNKYNKCDDNKYDTCDDNKYDTCDDNKYDTCDDNKYNKYDDDKYDTCDDNKYNKYDDDKYNKYDDDKYNKYDDDKYEKSRKKKKLNNLYKTILTKKKRKKMNSNLCVINKIYKYPIKYCELNSKAFVFFIIKNVGVHKITYYSYNKLFSKDGVLNQGIQICKLYHVNKNKKIKQIIFEALKNKITFSYDNNPNNIKKKIYKFLKKNCAYHDLIKLFYFKGHKQREKCNKKLNMEKTFGVHKSSRYNYKTYKKKKKIDMCKNYCDDILDTYNSKYYKGELSGQHKHIKMTGEQKEEHHIKYTHLNFNHGKDETFYKELYKCNYIEKYISSVNYFLLERRRMFNKYKQQELCVNKNEENNKNKNDDDNKNDDDNKNDDDNNKNDDDNKNDDDDNKNDDDNKNDDDDNKNDDDDNNKNNIQCDNHSDNIYMCGTYGNMENYNVPHSTNNTNLQSIKKRIINMNILDNIRCNKTYKYIDKNKFKCFTYYSCKNYNVCKKIIEKYKLYKFLKKKKIEGYMILNFLNFNKELIYYNEHKKDMSTLHDNLFDVISNNQNENVKYNHICNNNKYDWFFNSFDYVGNLEESITCFNNHKKKENMKNIKNIKKKKKKNLFYNEQHNIKNNKNDYHFDKYPSSLYSHLTNKKMVNNTEVNNIKDENSLQMYIINKDVTKNKDGNLLLNSYYNSKLGKSINTCSKEIYKEEHKNVYIYNKKITKMNIKMKTEQKYICVDSKRNTRTYNSKNIRTYNSKNIRTYNSKNIRTYNRKNIRTYNRKNIRTYNRKNIRTYNRKNIRCNNRKKFHLNRNKKKNGCVKKYKLYDERNTLVYKNKIGSNHFFLKEEIGKSTKKLNDIFEHISNYTNRISKNINITNKNRYDDYPFDFLSKDKIEYISMLSPTINEIKTLNTILTIPLIKMNEYEKNCIWRFRFQLLNRKETLGKFLKSINWNNKEEEEEAIILLNKWAKPGIENCIELFYSHLHHYVIKKYIIDIIKNSKKEEIKLYLFQLVQSLRTFNYQHIDNLFINTLIQKCIKSKKLSIYFYWFLLSEAKDKIKGKLYLHIHKLFINKLMTSNIRKNKIILDILKNQNRFRNQLLYLTKIAKNKTDRIQNKTRKLRNFLFYYRTNYGYINIKDFIKNNIFISDHNVYDFLDICKMKRENSLDTPMRGDNIGQPSYLGMVPGMGKSTDDSKNVYGDDNKNVYGDDNKNVYGDDSKNIYCDDNKNVYGDDNKNIYGDDSKNIYGDDNKNIFSDDNKNLYSDNNNNKHIRYNKYVKNISYEHFNEYPYDNKKSRNIYTCNKDICNSIYYLDNELTINYDIKDDLYFFQYKRSSDEKLLNTDLSNDSNDMIHYIDDSKNVKIERNRDNSFFSNFLQFNDNLDFFLNATYSDEDNNYEILDDSINFVQKQKIKKIKTPLILPIDPNIELLSFLPEQSYVLRSSLYPIVIACLVRKKIKLYNENYNNLIINNHTFYKNDQNKDNIINNLSYDKSYHSYYNSQFIKTLQNSFESTTSLNYHYNFLKCSNNNIFYKNKKIERIKPNTSIQKAFPSNENILNRNQHVYYSNNQIVHNIKKMNKHKRDDYMINEKVLPCVSNSCLGDKLMPSHDKMRSSHDKMMPSHDKMMPSHDKLMSPHYTLMSSHDKPVAPSGVSSLGEKKSKDEKKNRKKYNEIYQLSIKKYIYKAGDDLRQDHLVIQIIYVMDNIWKRYGLDLKMTLYRVLALSTDDGFIEFVDYAESISSIKKNYKGEIRQYFIDNSTCSSSPLGFDTEILQNFISSCAGYSVITYILGIGDRHLDNLMVTKDGRFFHIDFGYIFGEDPKPFSPPMKLCKEMIEAMGGAHSIGYEQFLKKCCLAYKYLRYHSQLIISLLDAMCDAGLKDMKMSPELCVLKVQEKFRLDLNDEAAEIYFLSVINASVKTLFPVVVDKLHEWALNWK DIP protein Q8I3V5 original sequence version: 90 q8i3v5_plaf7-q8idq2_plaf7-1 4 5 unspecified role unspecified role prey prey Q8IDQ2:p.Cys580Tyr C580Y mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain C Y This feature has been corrected as a result of our quality control procedures. The original label was 'C580Y'. Wed May 02 18:53:59 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys580tyr' Tue Jun 30 20:07:57 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys580Tyr' HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 7 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association q8i3v5_plaf7-ub-1 3 6 unspecified role unspecified role prey prey human Homo sapiens Human 7 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association q8i3v5_plaf7-q8idq2_plaf7-2 1 5 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 6 unspecified role unspecified role prey prey human Homo sapiens Human 7 unspecified role unspecified role bait bait human Homo sapiens Human association association q8idq2_plaf7-q8i3v5_plaf7-1 2 5 unspecified role unspecified role bait bait Q8IDQ2:p.Cys580Tyr C580Y mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain C Y This feature has been corrected as a result of our quality control procedures. The original label was 'C580Y'. Wed May 02 16:51:37 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'cys580tyr' Tue Jun 30 18:06:25 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Cys580Tyr' HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 7 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association