DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural basis of latrophilin-FLRT interaction. Structural basis of latrophilin-FLRT interaction. Structure (London, England : 1993) 2015 imex curation Jackson VA., del Toro D., Carrasquero M., Roversi P., Harlos K., Klein R., Seiradake E. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Jackson VA., del Toro D., Carrasquero M., Roversi P., Harlos K., Klein R., Seiradake E. DIP original experiment: DIP-264849X Structure (London, England : 1993) 2015 IMEx Structural basis of latrophilin-FLRT interaction. Structural basis of latrophilin-FLRT interaction. Structural basis of latrophilin-FLRT interaction. Structure (London, England : 1993) 2015 imex curation Jackson VA., del Toro D., Carrasquero M., Roversi P., Harlos K., Klein R., Seiradake E. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Jackson VA., del Toro D., Carrasquero M., Roversi P., Harlos K., Klein R., Seiradake E. DIP original experiment: DIP-264850X Structure (London, England : 1993) 2015 IMEx Structural basis of latrophilin-FLRT interaction. agrl3_mouse Adhesion G protein-coupled receptor L3 Adgrl3 Kiaa0768 Latrophilin-3 Lec3 Lectomedin-3 Lphn3 protein protein mouse Mus musculus Mouse MWPPQLLILTMLLAPVVHGGKHNERHPALAAPLRHAERSPGGALPPRHLLQQPAAERSTAHRGQGPRGAARGVRGPGAPGAQIAAQAFSRAPIPMAVVRRELSCESYPIELRCPGTDVIMIESANYGRTDDKICDSDPAQMENIRCYLPDAYKIMSQRCNNRTQCAVVAGPDVFPDPCPGTYKYLEVQYECVPYKVEQKVFLCPGLLKGVYQSEHLFESDHQSGAWCKDPLQASDKIYYMPWTPYRTDTLTEYSSKDDFIAGRPTTTYKLPHRVDGTGFVVYDGALFFNKERTRNIVKFDLRTRIKSGEAIIANANYHDTSPYRWGGKSDIDLAVDENGLWVIYATEQNNGKIVISQLNPYTLRIEGTWDTAYDKRSASNAFMICGILYVVKSVYEDDDNEATGNKIDYIYNTDQSKDSLVDVPFPNSYQYIAAVDYNPRDNLLYVWNNYHVVKYSLDFGPLDSRSGPVHHGQVSYISPPIHLDSELERPPVRGISTTGSLGMGSTTTSTTLRTTTWNIGRSTTASLPGRRNRSTSTPSPAVEVLDDVTTHLPSAASQIPAMEESCEAVEAREIMWFKTRQGQVAKQPCPAGTIGVSTYLCLAPDGIWDPQGPDLSNCSSPWVNHITQKLKSGETAANIARELAEQTRNHLNAGDITYSVRAMDQLVGLLDVQLRNLTPGGKDSAARSLNKLQKRERSCRAYVQAMVETVNNLLQPQALNAWRDLTTSDQLRAATMLLDTVEESAFVLADNLLKTDIVRENTDNIQLEVARLSTEGNLEDLKFPENMGHGSTIQLSANTLKQNGRNGEIRVAFVLYNNLGPYLSTENASMKLGTEAMSTNHSVIVNSPVITAAINKEFSNKVYLADPVVFTVKHIKQSEENFNPNCSFWSYSKRTMTGYWSTQGCRLLTTNKTHTTCSCNHLTNFAVLMAHVEVKHSDAVHDLLLDVITWVGILLSLVCLLICIFTFCFFRGLQSDRNTIHKNLCISLFVAELLFLIGINRTDQPIACAVFAALLHFFFLAAFTWMFLEGVQLYIMLVEVFESEHSRRKYFYLVGYGMPALIVAVSAAVDYRSYGTDKVCWLRLDTYFIWSFIGPATLIIMLNVIFLGIALYKMFHHTAILKPESGCLDNINYEDNRPFIKSWVIGAIALLCLLGLTWAFGLMYINESTVIMAYLFTIFNSLQGMFIFIFHCVLQKKVRKEYGKCLRTHCCSGKSTESSIGSGKTSGSRTPGRYSTGSQSRIRRMWNDTVRKQSESSFITGDINSSASLNREGLLNNARDTSVMDTLPLNGNHGNSYSIAGGEYLSNCVQIIDRGYNHNETALEKKILKELTSNYIPSYLNNHERSSEQNRNMMNKLVNNLGSGSEDDAIVLDDAASFNHEESLGLELIHEESDAPLLPPRVYSTDNHQPHHYSRRRFPQDHSESFFPLLTDEHTEDLQSPHRDSLYTSMPALAGVPAADSVTTSTQTEAAAAKGGDAEDVYYKSMPNLGSRNHVHPLHAYYQLGRGSSDGFIVPPNKDGASPEGTSKGPAHLVTSL DIP protein Q80TS3 original sequence version: 116 DIP protein Q80TS3 original sequence version: 121 F55EAB142C987A69 flrt2_mouse Leucine-rich repeat transmembrane protein FLRT2 Flrt2 Kiaa0405 Fibronectin leucine rich transmembrane protein 2 protein protein mouse Mus musculus Mouse MGLQTTKWPGRGAFILKFWLIISLGLYLQVSKLLACPSVCRCDRNFVYCNERSLTSVPLGIPEGVTVLYLHNNQINNAGFPAELHNVQSVHTVYLYGNQLDEFPMNLPKNVRVLHLQENNIQTISRAALAQLLKLEELHLDDNSISTVGVEDGAFREAISLKLLFLSKNHLSSVPVGLPVDLQELRVDENRIAVISDMAFQNLTSLERLIVDGNLLTNKGIAEGTFSHLTKLKEFSIVRNSLSHPPPDLPGTHLIRLYLQDNQINHIPLTAFANLRKLERLDISNNQLRMLTQGVFDHLSNLKQLTARNNPWFCDCSIKWVTEWLKYIPSSLNVRGFMCQGPEQVRGMAVRELNMNLLSCPTTTPGLPVFTPAPSTVSPTTQSPTLSVPSPSRGSVPPAPTPSKLPTIPDWDGRERVTPPISERIQLSIHFVNDTSIQVSWLSLFTVMAYKLTWVKMGHSLVGGIVQERIVSGEKQHLSLVNLEPRSTYRICLVPLDAFNYRTVEDTICSEATTHASYLNNGSNTASSHEQTTSHSMGSPFLLAGLIGGAVIFVLVVLLSVFCWHMHKKGRYTSQKWKYNRGRRKDDYCEAGTKKDNSILEMTETSFQIVSLNNDQLLKGDFRLQPIYTPNGGINYTDCHIPNNMRYCNSSVPDLEHCHT DIP protein Q8BLU0 original sequence version: 120 adgrl3-flrt2-1 1 4 unspecified role unspecified role prey prey Region 35-540 Region 35-540 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 3 unspecified role unspecified role bait bait Region 202-463 Region 202-463 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q80TS3:p.[Arg292Asn;Arg294Thr] R292N/R294T mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R T certain certain sequence position certain certain certain sequence position certain R N This feature has been corrected as a result of our quality control procedures. The original label was 'R292N/R294T'. Wed May 02 19:46:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg292asn,arg294thr' Tue Jun 30 19:56:11 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg292Asn;Arg294Thr]' Q80TS3:p.[Arg324Asn;Gly326Thr] R324N/G326T mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R N certain certain sequence position certain certain certain sequence position certain G T This feature has been corrected as a result of our quality control procedures. The original label was 'R324N/G326T'. Wed May 02 18:37:13 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg324asn,gly326thr' Tue Jun 30 16:53:53 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg324Asn;Gly326Thr]' Q80TS3:p.[Pro244Asn;Arg246Thr] P244N/R246T mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain R T certain certain sequence position certain certain certain sequence position certain P N This feature has been corrected as a result of our quality control procedures. The original label was 'P244N/R246T'. Wed May 02 17:26:15 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro244asn,arg246thr' Tue Jun 30 17:22:55 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Pro244Asn;Arg246Thr]' Q80TS3:p.[Thr267Asn;Lys269Thr] T267N/K269T mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K T certain certain sequence position certain certain certain sequence position certain T N This feature has been corrected as a result of our quality control procedures. The original label was 'T267N/K269T'. Wed May 02 15:16:03 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr267asn,lys269thr' Tue Jun 30 20:18:07 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Thr267Asn;Lys269Thr]' human Homo sapiens Human direct interaction direct interaction flrt2-adgrl3-1 2 4 unspecified role unspecified role bait bait Region 35-540 Region 35-540 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q8BLU0:p.[Arg186Asn;Asp188Thr] R186N/D188T mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain D T certain certain sequence position certain certain certain sequence position certain R N This feature has been corrected as a result of our quality control procedures. The original label was 'R186N/D188T'. Wed May 02 16:33:23 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg186asn,asp188thr' Tue Jun 30 20:20:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg186Asn;Asp188Thr]' human Homo sapiens Human 3 unspecified role unspecified role prey prey Region 202-463 Region 202-463 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction