DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A molecular mechanotransduction pathway regulates collective migration of epithelial cells. A molecular mechanotransduction pathway regulates collective migration of epithelial cells. Nature cell biology 2015 imex curation Das T., Safferling K., Rausch S., Grabe N., Boehm H., Spatz JP. Only protein-protein interactions canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Das T., Safferling K., Rausch S., Grabe N., Boehm H., Spatz JP. DIP original experiment: DIP-266132X Nature cell biology 2015 IMEx A molecular mechanotransduction pathway regulates collective migration of epithelial cells. A molecular mechanotransduction pathway regulates collective migration of epithelial cells. A molecular mechanotransduction pathway regulates collective migration of epithelial cells. Nature cell biology 2015 imex curation Das T., Safferling K., Rausch S., Grabe N., Boehm H., Spatz JP. Only protein-protein interactions canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Das T., Safferling K., Rausch S., Grabe N., Boehm H., Spatz JP. DIP original experiment: DIP-266134X Nature cell biology 2015 IMEx A molecular mechanotransduction pathway regulates collective migration of epithelial cells. A molecular mechanotransduction pathway regulates collective migration of epithelial cells. A molecular mechanotransduction pathway regulates collective migration of epithelial cells. Nature cell biology 2015 imex curation Das T., Safferling K., Rausch S., Grabe N., Boehm H., Spatz JP. Only protein-protein interactions canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Das T., Safferling K., Rausch S., Grabe N., Boehm H., Spatz JP. DIP original experiment: DIP-266136X Nature cell biology 2015 IMEx A molecular mechanotransduction pathway regulates collective migration of epithelial cells. A molecular mechanotransduction pathway regulates collective migration of epithelial cells. A molecular mechanotransduction pathway regulates collective migration of epithelial cells. Nature cell biology 2015 imex curation Das T., Safferling K., Rausch S., Grabe N., Boehm H., Spatz JP. Only protein-protein interactions canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Das T., Safferling K., Rausch S., Grabe N., Boehm H., Spatz JP. DIP original experiment: DIP-266135X Nature cell biology 2015 IMEx A molecular mechanotransduction pathway regulates collective migration of epithelial cells. A molecular mechanotransduction pathway regulates collective migration of epithelial cells. A molecular mechanotransduction pathway regulates collective migration of epithelial cells. Nature cell biology 2015 imex curation Das T., Safferling K., Rausch S., Grabe N., Boehm H., Spatz JP. Only protein-protein interactions canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Das T., Safferling K., Rausch S., Grabe N., Boehm H., Spatz JP. DIP original experiment: DIP-266133X Nature cell biology 2015 IMEx A molecular mechanotransduction pathway regulates collective migration of epithelial cells. f1pfk4_canlf PARD3 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris DPNYWIQVHRLEHGDGGILDLDDTLCDVADDKDRLVAVFDEQDPHHGGDGTSASSTGTQSPEIFGSELGTNNVSAFQPYQATSEIEVTPSVLRANMPLHVRRSSDPALIGLSTSISDTNFSSEEPSRKNPTRWSTTAGFLKQNTAGSPKTCDRKDEDGTEDNSRVEPVGHADTGLENISSFSLDDMVKLVQVPNDGGPLGIHVVPFSARGGRTLGLLVKRLEKGGKAEQENLFHENDCIVRINDGDLRNRRFEQAQHMFRQAMRTPIIWFHVVPAANKEQYEQLSQSEKNNYYSSHFSPDSQYMDNRGVTSAGLQALPRAPRLNHPPEHIDSHPRLLPQSTHPSGKPPSALAQAPQNIFSPNVSSGYNTKKIGKRLNIQLKKGTEGLGFSITSRDVTIGGSAPIYVKNILPRGAAIQDGRLKAGDRLIEVNGVDLAGKSQEEVVSLLRSTKMEGTVSLLVFRQEDAFHPRELKAEDEDIVLTPDGTREFLTFEVPLNDSGSAGLGVSVKGNRSKENHADLGIFVKSIINGGAASKDGRLRVNDQLIAVNGESLLGKTNQDAMETLRRSMSTEGNKRGMIQLIVARRISKCNELKSPGSPSGPELPIETVLDDRERRISHSLYSGIEGLDESPTRNAALSRIMGKYQLSPTVNMPQDDTVIIEDDRLPVLPPHLSDQSSSSSHDDVGFVTTDTGTWSKAAINDSADCSLSPDVDPVLAFQREGFGRQSMSEKRTKQFSDASQLDFVKTRKSKSMDLGIADETKLNTVDDQKAGSPSRDVGPSLGLKKSSSLESLQTAVAEVTLNGDIPFHRPRPRIIRGRGCNESFRAAIDKSYDKPTVDDDDEGMETLEEDTEESSRSGRESVSTASDQPSHSLERHMNGNQEKGDKMDRRKDKAGKEKKKDRDKEKDKMKAKKGMLKGLGDMFRFGKHRKDDKIEKTGKIKIQDSLTSEEERIRMKQEQERIQAKTREFRERQARERDYAEIQDFHRTLGCNDELMYGGMSSYEGSMALNTRPQSPREGHTMDALYAQVKKPRNSKPSSVDSNRSTPSNHDRIQRLRQEFQQAKQDEDVEDRRRTYSFEQPWPSSRAAAQSGRHSVSVEVQMQRQRQEERDGFQQAQRQYSSLPRQSRKNASSVSQDSWEQNYPPGEGFQSAKENPRYSSYQGSRNGYLGGHGFNARVMLETQELLRQEQRRKEQQMKKQPPLLPEGLHNYDSYKKGQDPTYTPPKGPFRQDVPPSPSQVARLNRIQTPEKGKPFYS DIP protein F1PFK4 original sequence version: 24 01D3FC364FBDD6D1 p35240-1 Merlin I NF2 SCH Moesin-ezrin-radixin-like protein Neurofibromin-2 Schwannomerlin Schwannomin protein protein human Homo sapiens Human MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEIATKPTYPPMNPIPAPLPPDIPSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGSSKHNTIKKLTLQSAKSRVAFFEEL DIP protein P35240-1 original sequence version: 177 B1A1BF2BD5DA561C e2qzz2_canlf NF2 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MAGAIASRMSFSSLKRKQPKTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIKDTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFFLQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELLPKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGVNYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDKEFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRKADSLEVQQMKAQAREEKARKQMERQRLAREKQMREEAERTRDELERRLLQMKEEATMANEALMRSEETADLLAEKAQITEEEAKLLAQKAAEAEQEMQRIKATAIRTEEEKRLMEQKVLEAEVLALKMAEESERRAKEADQLKQDLQEAREAERRAKQKLLEITTKPTYPPMNPIPAPLPPDISSFNLIGDSLSFDFKDTDMKRLSMEIEKEKVEYMEKSKHLQEQLNELKTEIEALKLKERETALDILHNENSDRGGTSSKHNTIKKVPSLLSRVIRLLFFMHT DIP protein E2QZZ2 original sequence version: 34 0A30568EF0BC8BCC e2rem4_canlf ARHGAP17 protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MTREGGAGREPPPPPPGSDVGSPGRPPAPGRARAAAAAMKKQFNRMKQLANQTVGRAEKTEVLSEDLLQIERRLDTVRSVCHLSHKRLTACFQGQHGSDAERRYKKLPLTALAQIMQEASTQLEDSLLGKMLETCGDAENQLALELTQHESFVEKEIVDPLCNIAELEIPNIQKQRKQLAKLVLDWDSVRARWNQAHKSSGTNFQGLPSKIDTLKEEMDEAGNKVELCKDQLAADMYSFMSKEGEYGKFFVTLLEAQADYHRKALAVLEKALPEMRAHQDKWAEKPAFGTPLEEHLKRSGREIALPIEACVMLLLETGMKEEGLFRIGAGASKLKKLKAALDCSTSHLDEFYSDPHAVAGALKSYLRELPEPLMTFNLYEEWTQVASVQDQDKKLQDLWRTCQKLPPQNFVNFRYLIKFLAKLAQTSDVNKMTPSNIAIVLGPNLLWAKTEGSLAEMAAATSVHVVAVIEPIIQHADWFFPEEVEFNVSEAFVPLVTPNSNHSSHTGNDSDSGTLERKRPASMAVMEGDLVKKESFGVKLMDFQAHRRGGTLNRKHISPAFQPPLPPTDGSTLAPAGPEPPPQSSRAESSTGGGTVPSSAGILEQGPSPGDSPAKPKDPAPAPAPAPGRNSSQMAAGQNQAQTAAGSHQLSVGPGHNSAGPSPHTVRRAVKKPAPAPPKPGNPPPGHPGGQSSPGASQHPPSLSPKPATRSPSPPAQHTGQAPAQPCATSQPSAPRRYSSSLSPIQAPSHPPPQPPTQAALPGHIKPSGQGPPTPGALLGEPGLEQPPHTPPQTPTPPSTPPLGKQNPSLPASQTQPVSNPETAQPHAGTLPRPRPVPKPRNRPSVPPPPHPPGAHSAGDSALANAAPTASKIVTDASSRLSEPLRSTFPDMHSDSASKDLPGRILLDIDNDTESTAL DIP protein E2REM4 original sequence version: 28 e2rjv1_canlf AMOT protein protein canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris MRNSEEQPSGGTTVLQRLLQEQLRYGNPNENRNLLAIHQQATGNGPPFPSSSGNPGPQNDVLSPQDHHQQLVAHAARQEPQGQEIQAENIIMEKQLSPRMQNNEELPTYEEAKVQSQYFRGQQHASVGAAFYVTGVTNQKMRTEGRPSVQRLNPGKMHQDEGLRDLKQGHVRSLSERLMQMSLATSGVKAHPPVTSAPLSPPQPSDLYKTPTSSSEFYKAQGPPPSQHSLKGMEHRGPPPEYPFKGMPPQSVVCKPQEAGHFYSEHRLNQPGRTEGQLMRYQHPPEYGAARPAQDISLPLSARSSRPHSPTSSLTSGGSLSLLQSPPATRLSPAQHPLAPNQGDHSAHLPRPQQHFLPTPAHQSDHYRLPQPGLSQPPPQQHHHHHHQQQPGEAYSAMPRAQQSSASYQPMPADPFAIVSRAQQMVEILSDENRNLRQELEGCYEKVARLQKVETEIQRVSEAYENLVKSSSKREALEKAMRNKLEGEIRRMHDFNRDLRERLETANKQLAEKEYEGSEDTRKTISQLFAKNKESQKEKEKLEAELATARSTNEDQRRHIEIRDQALSNAQAKVVKLEEELKKKQVYVDKVEKMQQALVQLQAACEKREQLEHRLRTRLERELESLRIQQRQGNSQPTNVSEYNATALMELLREKEERILALEADMTKWEQKYLEENVMRHFALDAAATVAAQRDTTVISHSPNTSYDTALEARIQKEEEEILMANKRCLDMEGRIKTLHAQIIEKDAMIKVLQQRSRKEPSKTEQLSSMRPAKSLMSISNAGSGLLSHSSTLTGTPIMEEKRDDKSWKGSLGILLGGDYRVESVPSTPSPVPPSTPLLSAHSKTGSRDCSTQTERGTEPNKTAAVAPISVPMPAASAAAAATITANAATNTATAATTTTTMVATAPVAVAAAAAPAATASAPSPAAATALAATAVSSAPATPILAAASAAAAAAAAAAAAVAPTAAVQVSSAAPAPLPASATAPVLAPQASQASASAPTQAPTPAPAAASPPAPAPAPAPALALAEASSSPAASSGSRRLSIPSVTCSPDKTDGPVFHSNTLERKAPIQLLGQEPDAEMVEYLI DIP protein E2RJV1 original sequence version: 29 nf2-amot-2 1 10 unspecified role unspecified role prey prey canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris 7 unspecified role unspecified role bait bait Region 488-595 Region 488-595 required to bind necessary binding region required to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris physical association physical association amot-nf2-1 3 8 unspecified role unspecified role prey prey canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris 10 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris physical association physical association nf2-pard3-1 2 6 unspecified role unspecified role prey prey canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris 7 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Region 1-325 Region 1-325 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris physical association physical association nf2-amot-3 5 6 unspecified role unspecified role prey prey canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris 10 unspecified role unspecified role prey prey canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris 7 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris association association amot-arhgap17-5 4 9 unspecified role unspecified role prey prey canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris 8 unspecified role unspecified role prey prey canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris 10 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range canlf Canis familiaris (dog) Canis lupus familiaris Dog Canis familiaris association association