DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature 2015 imex curation Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265505X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature 2015 imex curation Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions bovin Bos taurus (Bovine) Bovine pull down pull down predetermined predetermined participant predetermined Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265507X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature 2015 imex curation Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions bovin Bos taurus (Bovine) Bovine anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265503X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature 2015 imex curation Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions bovin Bos taurus (Bovine) Bovine pull down pull down western blot western blot Immuno blot Immuno blot Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265506X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature 2015 imex curation Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions bovin Bos taurus (Bovine) Bovine anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265504X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. Nature 2015 imex curation Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. Only protein-protein interactions bovin Bos taurus (Bovine) Bovine anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Marsolier J., Perichon M., DeBarry JD., Villoutreix BO., Chluba J., Lopez T., Garrido C., Zhou XZ., Lu KP., Fritsch L., Ait-Si-Ali S., Mhadhbi M., Medjkane S., Weitzman JB. DIP original experiment: DIP-265508X Nature 2015 IMEx Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation. fbxw7_bovin F-box/WD repeat-containing protein 7 FBXW7 FBW7 F-box and WD-40 domain-containing protein 7 protein protein bovin Bos taurus (Bovine) Bovine MNQELLSVGSKRRRTGGSLRGNPSSSQADEEQMNRVLEEEQQQPRHQEEEHAARNGEVVGAEPRPGDQNDPQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHRNSVTNSNSIVDLPIHQRSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK DIP protein F1MNN4 original sequence version: 33 4705609943F62B6C jun_bovin Transcription factor AP-1 JUN Activator protein 1 Proto-oncogene c-Jun V-jun avian sarcoma virus 17 oncogene homolog protein protein bovin Bos taurus (Bovine) Bovine MTAKMETTFYDDALNASFLQSESGAYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVSGAGLVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGSLSSGGGAPSYGAAGLAFPAQPQQQQQQPPQPPHHLPQQIPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF DIP protein O77627 original sequence version: 98 ubiq_bovin Ubiquitin RPS27A UBA80 UBCEP1 UBA52 UBCEP2 UBB UBC protein protein bovin Bos taurus (Bovine) Bovine MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG C42A35397FFD9B52 pin1_thean Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 Peptidyl-prolyl cis-trans isomerase Pin1 Rotamase Pin1 TA18945 protein protein thean Theileria annulata MIRNFLNFLWNNTSLRFLIINTIIFAMDKVRCAHLLLKHTGSRNPVNRNTGMAVTRTKEEAVSEMKGYLEMLRKSDNLDQEFRRLATAKSECSSARKGGDLGFFDRNTMQKPFTEASFKLEVNEISDLVETDSGVHLIYRIA DIP protein Q4UG71 original sequence version: 44 fbxw7_mouse F-box/WD repeat-containing protein 7 Fbxw7 Fbw7 Fbwd6 Fbxw6 F-box and WD-40 domain-containing protein 7 F-box protein FBW7 F-box protein Fbxw6 F-box-WD40 repeat protein 6 SEL-10 protein protein mouse Mus musculus Mouse MNQELLSVGSKRRRTGGSLRGNASSSQVDEGQMNRVVEEDPQQQARHQEEEHTARNGELVGANPRPGDQNDTQQGQVEENNNRFISVDEDSSGNQEEQEEDEEHAGEQEEEEEEEEEEEEMDQESDDFDPSDDSSREDEHTHNSNVTNCSSVSDLPAHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSDYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK DIP protein Q8VBV4 original sequence version: 113 DIP protein Q8VBV4 original sequence version: 118 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 mint 9D56F7E81E6E390B fbxw7_human F-box/WD repeat-containing protein 7 FBXW7 FBW7 FBX30 SEL10 F-box and WD-40 domain-containing protein 7 F-box protein FBX30 Archipelago homolog SEL-10 hCdc4 protein protein human Homo sapiens Human MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK DIP protein Q969H0 original sequence version: 61 DIP protein Q969H0 original sequence version: 70 DIP protein Q969H0 original sequence version: 94 DIP protein Q969H0-1 original sequence version: 85 DIP protein Q969H0 original sequence version: 104 DIP protein Q969H0 original sequence version: 130 DIP protein Q969H0-1 original sequence version: 135 E4A357F76DFD8203 pin1_human Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Rotamase Pin1 Peptidyl-prolyl cis-trans isomerase Pin1 PIN1 protein protein human Homo sapiens Human MADEEKLPPGWEKRMSRSSGRVYYFNHITNASQWERPSGNSSSGGKNGQGEPARVRCSHLLVKHSQSRRPSSWRQEKITRTKEEALELINGYIQKIKSGEEDFESLASQFSDCSSAKARGDLGAFSRGQMQKPFEDASFALRTGEMSGPVFTDSGIHIILRTE DIP protein Q13526 original sequence version: 65 DIP protein Q13526 original sequence version: 64 DIP protein Q13526 original sequence version: 163 DIP protein Q13526 original sequence version: 156 DIP protein Q13526 original sequence version: 117 35391AF40B7D1E13 fbxw7-pin1-1 6 12 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range bovin Bos taurus (Bovine) Bovine 10 unspecified role unspecified role prey prey bovin Bos taurus (Bovine) Bovine physical association physical association jun-bub-1 3 9 unspecified role unspecified role prey prey bovin Bos taurus (Bovine) Bovine 8 unspecified role unspecified role bait bait bovin Bos taurus (Bovine) Bovine physical association physical association pin1-fbxw7-1 4 7 unspecified role unspecified role prey prey bovin Bos taurus (Bovine) Bovine 10 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli physical association physical association fbxw7-bub-1 5 7 unspecified role unspecified role bait bait bovin Bos taurus (Bovine) Bovine 9 unspecified role unspecified role prey prey bovin Bos taurus (Bovine) Bovine physical association physical association pin1-fbxw7-2 2 13 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 7 unspecified role unspecified role prey prey bovin Bos taurus (Bovine) Bovine physical association physical association pin1-fbxw7-3 1 11 unspecified role unspecified role prey prey mouse Mus musculus Mouse 10 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse physical association physical association