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  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
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      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
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        <names>
          <fullName>Modeling an in-register, parallel "iowa" aβ fibril structure using solid-state NMR data from labeled samples with rosetta.</fullName>
        </names>
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            <attribute name="publication year" nameAc="MI:0886">2015</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
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            <attribute name="dataset" nameAc="MI:0875">Alzheimers - Interactions investigated in the context of Alzheimers disease</attribute>
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            <shortLabel>solid state nmr</shortLabel>
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          <attribute name="author-list" nameAc="MI:0636">Sgourakis NG., Yau WM., Qiang W.</attribute>
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          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-264726X</attribute>
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          <attribute name="publication year" nameAc="MI:0886">2015</attribute>
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          <fullName>Modeling an in-register, parallel "iowa" aβ fibril structure using solid-state NMR data from labeled samples with rosetta.</fullName>
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          <names>
            <shortLabel>tem</shortLabel>
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          <attribute name="author-list" nameAc="MI:0636">Sgourakis NG., Yau WM., Qiang W.</attribute>
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        </attributeList>
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    <interactorList>
      <interactor id="3">
        <names>
          <shortLabel>p05067-pro_0000000093</shortLabel>
          <fullName>Amyloid-beta protein 40</fullName>
          <alias type="gene name" typeAc="MI:0301">APP</alias>
          <alias type="gene name synonym" typeAc="MI:0302">A4</alias>
          <alias type="gene name synonym" typeAc="MI:0302">AD1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">ABPP</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Alzheimer disease amyloid protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Cerebral vascular amyloid peptide</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PreA4</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Protease nexin-II</alias>
          <alias type="gene name synonym" typeAc="MI:0302">APPI</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Amyloid precursor protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Amyloid-beta A4 protein</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Alzheimer disease amyloid A4 protein homolog</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Amyloid-beta (A4) precursor protein</alias>
        </names>
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          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P05067-PRO_0000000093" refType="identity" refTypeAc="MI:0356"/>
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          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77613" refType="chain-parent" refTypeAc="MI:0951"/>
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        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
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          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
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        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV</sequence>
        <attributeList>
          <attribute name="chain-seq-start">672</attribute>
          <attribute name="chain-seq-end">711</attribute>
          <attribute name="crc64">D563D7858C3768F1</attribute>
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      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-24196-1">
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          <shortLabel>app-app-86</shortLabel>
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          <experimentRef>2</experimentRef>
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        <participantList>
          <participant id="5">
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            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
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                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
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                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
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                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="6">
                <names>
                  <shortLabel>P05067-PRO_0000000093:p.Asp23Asn</shortLabel>
                  <fullName>D23N</fullName>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-20764006" refType="identity" refTypeAc="MI:0356"/>
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                <featureType>
                  <names>
                    <shortLabel>mutation</shortLabel>
                    <fullName>mutation</fullName>
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                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0118" refType="identity" refTypeAc="MI:0356"/>
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                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
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                        <shortLabel>certain</shortLabel>
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                    <end position="23"/>
                    <resultingSequence>
                      <originalSequence>D</originalSequence>
                      <newSequence>N</newSequence>
                    </resultingSequence>
                  </featureRange>
                </featureRangeList>
                <attributeList>
                  <attribute name="remark-internal">This feature has been corrected as a result of our quality control procedures. The original label was 'D23N'.</attribute>
                  <attribute name="remark-internal">Wed May 02 19:06:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp23asn'</attribute>
                  <attribute name="remark-internal">Tue Jun 30 19:27:32 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp23Asn'</attribute>
                </attributeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="-2">
                <names>
                  <shortLabel>chemical synthesis</shortLabel>
                  <fullName>Chemical synthesis (Chemical synthesis)</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
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              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
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              <feature id="8">
                <names>
                  <shortLabel>P05067-PRO_0000000093:p.Asp23Asn</shortLabel>
                  <fullName>D23N</fullName>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-16136680" refType="identity" refTypeAc="MI:0356"/>
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                <featureType>
                  <names>
                    <shortLabel>mutation</shortLabel>
                    <fullName>mutation</fullName>
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                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
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                    <resultingSequence>
                      <originalSequence>D</originalSequence>
                      <newSequence>N</newSequence>
                    </resultingSequence>
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                </featureRangeList>
                <attributeList>
                  <attribute name="remark-internal">This feature has been corrected as a result of our quality control procedures. The original label was 'D23N'.</attribute>
                  <attribute name="remark-internal">Wed May 02 19:06:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp23asn'</attribute>
                  <attribute name="remark-internal">Tue Jun 30 18:26:32 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp23Asn'</attribute>
                </attributeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="-2">
                <names>
                  <shortLabel>chemical synthesis</shortLabel>
                  <fullName>Chemical synthesis (Chemical synthesis)</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
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      </interaction>
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        <names>
          <shortLabel>app-app-87</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-87879E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16136695" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-24196-2" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="10">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="11">
                <names>
                  <shortLabel>P05067-PRO_0000000093:p.Asp23Asn</shortLabel>
                  <fullName>D23N</fullName>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-20764011" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>mutation</shortLabel>
                    <fullName>mutation</fullName>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0118" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456558" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="23"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="23"/>
                    <resultingSequence>
                      <originalSequence>D</originalSequence>
                      <newSequence>N</newSequence>
                    </resultingSequence>
                  </featureRange>
                </featureRangeList>
                <attributeList>
                  <attribute name="remark-internal">This feature has been corrected as a result of our quality control procedures. The original label was 'D23N'.</attribute>
                  <attribute name="remark-internal">Wed May 02 16:54:03 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp23asn'</attribute>
                  <attribute name="remark-internal">Tue Jun 30 17:38:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp23Asn'</attribute>
                </attributeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="-2">
                <names>
                  <shortLabel>chemical synthesis</shortLabel>
                  <fullName>Chemical synthesis (Chemical synthesis)</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="12">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="13">
                <names>
                  <shortLabel>P05067-PRO_0000000093:p.Asp23Asn</shortLabel>
                  <fullName>D23N</fullName>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-16136700" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>mutation</shortLabel>
                    <fullName>mutation</fullName>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0118" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456558" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <begin position="23"/>
                    <endStatus>
                      <names>
                        <shortLabel>certain</shortLabel>
                        <fullName>certain sequence position</fullName>
                        <alias type="synonym" typeAc="MI:1041">certain</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0335" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-540564" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                    <end position="23"/>
                    <resultingSequence>
                      <originalSequence>D</originalSequence>
                      <newSequence>N</newSequence>
                    </resultingSequence>
                  </featureRange>
                </featureRangeList>
                <attributeList>
                  <attribute name="remark-internal">This feature has been corrected as a result of our quality control procedures. The original label was 'D23N'.</attribute>
                  <attribute name="remark-internal">Wed May 02 16:54:03 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asp23asn'</attribute>
                  <attribute name="remark-internal">Tue Jun 30 15:38:55 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asp23Asn'</attribute>
                </attributeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="-2">
                <names>
                  <shortLabel>chemical synthesis</shortLabel>
                  <fullName>Chemical synthesis (Chemical synthesis)</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>