DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. Structure (London, England : 1993) 2015 imex curation Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. Only protein-protein interactions in vitro In vitro epr electron paramagnetic resonance ESR EPR EPR ESR epr predetermined predetermined participant predetermined Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. DIP original experiment: DIP-264696X Structure (London, England : 1993) 2015 IMEx BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. Structure (London, England : 1993) 2015 imex curation Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. Only protein-protein interactions in vitro In vitro epr electron paramagnetic resonance ESR EPR EPR ESR epr predetermined predetermined participant predetermined Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. DIP original experiment: DIP-264698X Structure (London, England : 1993) 2015 IMEx BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. Structure (London, England : 1993) 2015 imex curation Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. Only protein-protein interactions in vitro In vitro epr electron paramagnetic resonance ESR EPR EPR ESR epr predetermined predetermined participant predetermined Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. DIP original experiment: DIP-264695X Structure (London, England : 1993) 2015 IMEx BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. Structure (London, England : 1993) 2015 imex curation Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. Only protein-protein interactions in vitro In vitro epr electron paramagnetic resonance ESR EPR EPR ESR epr predetermined predetermined participant predetermined Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. DIP original experiment: DIP-264699X Structure (London, England : 1993) 2015 IMEx BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. Structure (London, England : 1993) 2015 imex curation Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. Only protein-protein interactions in vitro In vitro epr electron paramagnetic resonance ESR EPR EPR ESR epr predetermined predetermined participant predetermined Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. DIP original experiment: DIP-264697X Structure (London, England : 1993) 2015 IMEx BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. Structure (London, England : 1993) 2015 imex curation Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. Only protein-protein interactions in vitro In vitro molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. DIP original experiment: DIP-264694X Structure (London, England : 1993) 2015 IMEx BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. BAX-induced apoptosis can be initiated through a conformational selection mechanism. Structure (London, England : 1993) 2015 imex curation Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. Only protein-protein interactions in vitro In vitro epr electron paramagnetic resonance ESR EPR EPR ESR epr predetermined predetermined participant predetermined Tsai CJ., Liu S., Hung CL., Jhong SR., Sung TC., Chiang YW. DIP original experiment: DIP-264700X Structure (London, England : 1993) 2015 IMEx BAX-induced apoptosis can be initiated through a conformational selection mechanism. q07813-1 Apoptosis regulator BAX Bax protein protein mouse Mus musculus Mouse MDGSGEQLGSGGPTSSEQIMKTGAFLLQGFIQDRAGRMAGETPELTLEQPPQDASTKKLSECLRRIGDELDSNMELQRMIADVDTDSPREVFFRVAADMFADGNFNWGRVVALFYFASKLVLKALCTKVPELIRTIMGWTLDFLRERLLVWIQDQGGWEGLLSYFGTPTWQTVTIFVAGVLTASLTIWKKMG DIP protein Q07813-1 original sequence version: 81 DIP protein Q07813 original sequence version: 154 DIP protein Q07813 original sequence version: 161 b2l11_human Bcl-2-like protein 11 BCL2L11 BIM Bcl2-interacting mediator of cell death protein protein human Homo sapiens Human MAKQPSDVSSECDREGRQLQPAERPPQLRPGAPTSLQTEPQGNPEGNHGGEGDSCPHGSPQGPLAPPASPGPFATRSPLFIFMRRSSLLSRSSSGYFSFDTDRSPAPMSCDKSTQTPSPPCQAFNHYLSAMASMRQAEPADMRPEIWIAQELRRIGDEFNAYYARRVFLNNYQAAEDHPRMVILRLLRYIVRLVWRMH DIP protein O43521 original sequence version: 48 DIP protein O43521-1 original sequence version: 71 DIP protein O43521 original sequence version: 132 DIP protein O43521 original sequence version: 143 D75735E469CA6997 bax-bcl2l11-5 2 9 unspecified role unspecified role unspecified role unspecified role Region 141-165 Region 141-165 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 8 unspecified role unspecified role unspecified role unspecified role R1-label R1-label r1 spin label r1 spin label certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction bax-bcl2l11-6 7 9 unspecified role unspecified role unspecified role unspecified role Region 141-165 Region 141-165 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 8 unspecified role unspecified role unspecified role unspecified role R1-label R1-label r1 spin label r1 spin label certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction bax-bcl2l11-7 6 9 unspecified role unspecified role unspecified role unspecified role Region 141-165 Region 141-165 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 8 unspecified role unspecified role unspecified role unspecified role Q07813-1:p.Lys21Glu K21E mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K21E'. Wed May 02 15:20:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys21glu' Tue Jun 30 18:24:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys21Glu' ecolx Escherichia coli direct interaction direct interaction bax-bcl2l11-8 1 9 unspecified role unspecified role unspecified role unspecified role Region 141-165 Region 141-165 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 8 unspecified role unspecified role unspecified role unspecified role R1-label R1-label r1 spin label r1 spin label certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction bax-bcl2l11-9 4 9 unspecified role unspecified role unspecified role unspecified role Region 141-165 Region 141-165 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 8 unspecified role unspecified role unspecified role unspecified role R1-label R1-label r1 spin label r1 spin label certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction bax-bcl2l11-10 3 9 unspecified role unspecified role unspecified role unspecified role Region 141-165 Region 141-165 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain R1-label R1-label r1 spin label r1 spin label c-term range C-terminal range c-term range c-term range C-terminal range c-term range in vitro In vitro 8 unspecified role unspecified role unspecified role unspecified role Q07813-1:p.Lys21Glu K21E mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K21E'. Wed May 02 15:44:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys21glu' Tue Jun 30 19:44:29 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys21Glu' ecolx Escherichia coli direct interaction direct interaction bax-bcl2l11-11 5 9 unspecified role unspecified role unspecified role unspecified role Region 141-165 Region 141-165 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain in vitro In vitro 8 unspecified role unspecified role unspecified role unspecified role R1-label R1-label r1 spin label r1 spin label certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction