DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262437X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262438X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262434X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions human Homo sapiens Human pull down pull down predetermined predetermined participant predetermined Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262447X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262435X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262439X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262440X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262436X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions mouse Mus musculus Mouse anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262445X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions in vitro In vitro pull down pull down autoradiography autoradiography Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262448X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262442X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262446X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions mouse Mus musculus Mouse pull down pull down western blot western blot Immuno blot Immuno blot Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262441X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262444X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Cyclin C is a haploinsufficient tumour suppressor. Nature cell biology 2014 imex curation Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Li N., Fassl A., Chick J., Inuzuka H., Li X., Mansour MR., Liu L., Wang H., King B., Shaik S., Gutierrez A., Ordureau A., Otto T., Kreslavsky T., Baitsch L., Bury L., Meyer CA., Ke N., Mulry KA., Kluk MJ., Roy M., Kim S., Zhang X., Geng Y., Zagozdzon A., Jenkinson S., Gale RE., Linch DC., Zhao JJ., Mullighan CG., Harper JW., Aster JC., Aifantis I., von Boehmer H., Gygi SP., Wei W., Look AT., Sicinski P. DIP original experiment: DIP-262443X Nature cell biology 2014 IMEx Cyclin C is a haploinsufficient tumour suppressor. ubiq_mouse Ubiquitin Rps27a Uba80 Ubcep1 Uba52 Ubcep2 Ubb Ubc protein protein mouse Mus musculus Mouse MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG C42A35397FFD9B52 med12_mouse Mediator of RNA polymerase II transcription subunit 12 Med12 Kiaa0192 Mopa Tnrc11 Trap230 Mediator complex subunit 12 OPA-containing protein Thyroid hormone receptor-associated protein complex 230 kDa component Trinucleotide repeat-containing gene 11 protein protein protein mouse Mus musculus Mouse MAAFGILSYEHRPLKRLRLGPPDVYPQDPKQKEDELTALNVKQGFNNQPAVSGDEHGSAKNVNFNPAKISSNFSSIIAEKLRCNTLSDTGRRKSLMNQKDNFWLVTARSQSAINTWFTDLAGTKPLTHLAKKVPIFSKKEEVFGYLAKYTVPVMRAAWLIKMTCAYYAAMSETKVKKKNTADPFTEWTQIITKYLWEQLQKMAEYYRPGPAGSGGCGSTIGPLPHDVEMAIRQWDYNEKLALFMFQDGMLDRHEFLTWVLECFEKIRPGEDELLKLLLPLLLRYSGEFVQSAYLSRRLAYFCTRRLALQLDGVSSHSSHVIAAQSTSSLPTTPAPQPPTSSTPSTPFSDLLMCPQHRPLVFGLSCILQTILLCCPSALVWHYSLTDSRIKTGSPLDHLPIAPSNLPMPEGNSAFTQQVRAKLREIEQQIKERGQAVEVRWSFDKCQEATAGFTIGRVLHTLEVLDSHSFERSDFSNSLDSLCNRIFGLGPSKDGHEISSDDDAVVSLLCEWAVSCKRSGRHRAMVVAKLLEKRQAEIEAERCGESEAADEKGSVASGSLSAPSAPIFQDVLLQFLDTQAPMLTDPRSESERVEFFNLVLLFCELIRHDVFSHNMYTCTLISRGDLAFGAPGPRPPSPFDDPTDDPERKEAEGSSSSKLEDPGLSESMDIDPSSSVLFEDMEKPDFSLFSPTMPCEGKGSPSPEKPDVEKEVKPPAKEKIEGTLGILYDQPRHVQYATHFPIPQEESCSHECNQRLVVLFGVGKQRDDARHAIKKITKDILKVLNRKGTAETDQLAPIVPLNPGDLTFLGGEDGQKRRRNRPEAFPTAEDIFAKFQHLSHYDQHQVTAQVSRNVLEQITSFALGMSYHLPLVQHVQFIFDLMEYSLSISGLIDFAIQLLNELSVVEAELLLKSSDLVGSYTTSLCLCIVAVLRHYHACLILNQDQMAQVFEGLCGVVKHGMNRSDGSSAERCILAYLYDLYTSCSHLKSKFGELFSDFCSKVKNTIYCNVEPSESNMRWAPEFMIDTLENPAAHTFTYTGLGKSLSENPANRYSFVCNALMHVCVGHHDPDRVNDIAILCAELTGYCKSLSAEWLGVLKALCCSSNNGTCGFNDLLCNVDVSDLSFHDSLATFVAILIARQCLLLEDLIRCAAIPSLLNAACSEQDSEPGARLTCRILLHLFKTPQLNPCQSDGNKPTVGIRSSCDRHLLAASQNRIVDGAVFAVLKAVFVLGDAELKGSGFTVPGGTEELPEEEGGGGSSGRRQGGRNISVETASLDVYAKYVLRSICQQEWVGERCLKSLCEDSNDLQDPVLSSAQAQRLMQLICYPHRLLDNEDGENPQRQRIKRILKNLDQWTMRQSSLELQLMIKQTPNTEMNSLLENIAKATIEVFQQSAETGSSSGSTASNMPSSSKTKPVLSSLERSGVWLVAPLIAKLPTSVQGHVLKAAGEELEKGQHLGSSSRKERDRQKQKSMSLLSQQPFLSLVLTCLKGQDEQREGLLASLHSQVHQIVINWRENQYLDDCKPKQLMHEALKLRLNLVGGMFDTVQRSTQQTTEWAQLLLEIIISGTVDMQSNNELFTTVLDMLSVLINGTLAADMSSISQGSMEENKRAYMNLVKKLQKDLGERQSDSLEKVHQLLPLPKQNRDVITCEPQGSLIDTKGNKIAGFDSIFKKEGLQVSTKQKISPWELFEGLKPSTAPLSWAWFGTVRVDRRVARGEEQQRLLLYHTHLRPRPRAYYLEPLPLPPEDEEPPAPALLEPEKKAPEPPKTDKPGAAPPSTEERKKKSTKGKKRSQPATKNEDYGMGPGRSGPYGVTVPPDLLHHANPGSISHLSYRQSSMGLYTQNQPLPAGGPRVDPYRPVRLPMQKLPTRPTYPGVLPTTMSTVMGLEPSSYKTSVYRQQQPTVPQGQRLRQQLQAKIQSQGMLGQSSVHQMTPSSSYGLQTSQGYTSYVSHVGLQQHTGPAGTMVPPSYSSQPYQSTHPSTNPTLVDPTRHLQQRPSGYVHQQAPTYGHGLTSTQRFSHQTLQQTPMMGTMTPLSAQGVQAGVRSTSILPEQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQYHIRQQQQQQQMLRQQQQQQQQQQQQQQQQQQQQQQQQQQQPHQQQQQAAPPQPQPQSQPQFQRQGLQQTQQQQQTAALVRQLQQQLSNTQPQPSTNIFGRY DIP protein A2AGH6 original sequence version: 35 DIP protein A2AGH6 original sequence version: 30 DIP protein A2AGH6 original sequence version: 64 146E05DCCFF38DB4 cdk3_human Cyclin-dependent kinase 3 CDK3 Cell division protein kinase 3 CDKN3 protein protein human Homo sapiens Human MDMFQKVEKIGEGTYGVVYKAKNRETGQLVALKKIRLDLEMEGVPSTAIREISLLKELKHPNIVRLLDVVHNERKLYLVFEFLSQDLKKYMDSTPGSELPLHLIKSYLFQLLQGVSFCHSHRVIHRDLKPQNLLINELGAIKLADFGLARAFGVPLRTYTHEVVTLWYRAPEILLGSKFYTTAVDIWSIGCIFAEMVTRKALFPGDSEIDQLFRIFRMLGTPSEDTWPGVTQLPDYKGSFPKWTRKGLEEIVPNLEPEGRDLLMQLLQYDPSQRITAKTALAHPYFSSPEPSPAARQYVLQRFRH DIP protein Q00526 original sequence version: 154 1128BE0096EA262A cdk19_human Cyclin-dependent kinase 19 CDK19 CDC2-related protein kinase 6 Death-preventing kinase Cyclin-dependent kinase 11 CDK11 KIAA1028 CDC2L6 Cell division cycle 2-like protein kinase 6 Cell division protein kinase 19 protein protein human Homo sapiens Human MDYDFKAKLAAERERVEDLFEYEGCKVGRGTYGHVYKARRKDGKDEKEYALKQIEGTGISMSACREIALLRELKHPNVIALQKVFLSHSDRKVWLLFDYAEHDLWHIIKFHRASKANKKPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPFHHDQLDRIFSVMGFPADKDWEDIRKMPEYPTLQKDFRRTTYANSSLIKYMEKHKVKPDSKVFLLLQKLLTMDPTKRITSEQALQDPYFQEDPLPTLDVFAGCQIPYPKREFLNEDDPEEKGDKNQQQQQNQHQQPTAPPQQAAAPPQAPPPQQNSTQTNGTAGGAGAGVGGTGAGLQHSQDSSLNQVPPNKKPRLGPSGANSGGPVMPSDYQHSSSRLNYQSSVQGSSQSQSTLGYSSSSQQSSQYHPSHQAHRY DIP protein Q9BWU1 original sequence version: 43 DIP protein Q9BWU1 original sequence version: 124 D9EED1BBB582EABA fbxw7_human F-box/WD repeat-containing protein 7 FBXW7 FBW7 FBX30 SEL10 F-box and WD-40 domain-containing protein 7 F-box protein FBX30 Archipelago homolog SEL-10 hCdc4 protein protein human Homo sapiens Human MNQELLSVGSKRRRTGGSLRGNPSSSQVDEEQMNRVVEEEQQQQLRQQEEEHTARNGEVVGVEPRPGGQNDSQQGQLEENNNRFISVDEDSSGNQEEQEEDEEHAGEQDEEDEEEEEMDQESDDFDQSDDSSREDEHTHTNSVTNSSSIVDLPVHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSEYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKVIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPNKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK DIP protein Q969H0 original sequence version: 61 DIP protein Q969H0 original sequence version: 70 DIP protein Q969H0 original sequence version: 94 DIP protein Q969H0-1 original sequence version: 85 DIP protein Q969H0 original sequence version: 104 DIP protein Q969H0 original sequence version: 130 DIP protein Q969H0-1 original sequence version: 135 E4A357F76DFD8203 med13_mouse Mediator of RNA polymerase II transcription subunit 13 Med13 Kiaa0593 Thrap1 Trap240 Thyroid hormone receptor-associated protein 1 Thyroid hormone receptor-associated protein complex 240 kDa component protein protein mouse Mus musculus Mouse MSSSFVSNGASLEDCHCNLFCLADLTGIKWKRYVWQGPTSAPILFPVTEEDPILSSFSRCLKADVLGVWRRDQRPGRRELWIFWWGKDPNFADLIHHDLSEEEDGVWENGLSYECRTLLFKAVHNLLERCLMNRNFVRIGKWFVKPYEKDEKPINKSEHLSCSFTFFLHGDSNVCTSVEINQHQPVYLLSEEHVTLAQQSNSPFQVILSPFGLNGTLTGQAFKMSDSATKKLIGEWKQFYPISCGLKEMSEEKQDDMDWEDDSLAAVEVLVAGVRMIYPACFVLVPQSDIPAPSSVGASHCSASCLGIHQVPASTRDPAMSSVTLTPPTSPEEVQTVDPQSAQKWVKFSSVSDGFSTDSTSHHGGKIPRKLANHVVDRVWQECNMNRLQNKRKYSATSSGLCEEETADKIGCWDFVEATQRTSCSCLRHKSLKTRNTGQQGQAPSLGQQQQVLPKHKTNEKQDKSEKPQKRPLTPFHHRVSVSDEIGMDTDSASQRLVISAADSQVRFSNIRTNDVAKTPQMHGTELANSPQPPPLSPHPCDVVDEGVTKTPSTPQSQHFYQMPTPDPLVPTKPMEDRIDSLSQSFPPPFQEAVEPTVYVGTAVSLEEDEANVAWKYYKVPKKKDVEFLPPQLPNDKFKDDPVGPFGQESVTSVTELMVQCKKPLKVSDEIVQQYQIKNQYLSAIASDTEQEPKIDPYAFVEGDEEFIFTDKKDRQNSEREAGKKHKVEDGTSAVTVLSHEEDAMSLFSPSKQDAPRPTNHARPPSTSLIYDSDLAVSYTDLDNLFNSDEDELTPGSKKSASGSDDKASSKESKTGNLDPLSCISTADLHKMYPTPPSLEQHIMGFSPMNMNNKEYGSVDTAPGGTVLEGNSSSVGTQFRIEVEEGFCSPKPSEIKDFSYVYKPENCQVLVGCSMFAPLKTLPSHCLPPIKLPEECVYRQSWTVGKLDLLPSGPSMPFIKEGDGSNLDQDYGPAYTPQTHASFGMPPSSAPPSNGGAGILPSPSTPRFPTPRTPRTPRTPRGAGGPASAQGSVKYENSDLYSPASTPSTCRPLNSVEPATVPSIPEAHSLYVNLILSESVMNLFKDCNFDSCCICVCNMNIKGADVGVYIPDPTQEAQYRCTCGFSAVMNRKFGNNSGLFLEDELDIIGRNTDCGKEAEKRFEALRASSVENVNGGLKESEKVPDELILLLQDQCTNLFSPFGAADQDPFPKVGISSNWVRVEERDCCSDCCLALEHGRQFMDNMSGGKVDEALVRSSCLHPWAKQNDASVQCSQDILRMLLSLQPVLQDAIQKKRTVRPWGVQGPLTWQQFHKMAGRGSYGTDESPEPLPIPTFLLGYDYDFLVLSPFALPYWEKLMLEPYGSQRDIAYVVLCPENEALLNGARSFFRDLTAIYESCRLGQHRPISRLLTDGIMKVGATASKKLSEKFVTEWFSQAADGNNEAFSKLKLYAQVCRYDLGPYLASQPLDSSLLSQPNLVAPPNQSLVTAPQMTNTGNANAPSATLASAASSTMTMTSGVPISTSVATANSTLTTTSSSSSSSLSSGVSSNKLPSFPPFGSMNTSGTGSMSAQASTVQSGQLGGQQSSSLQAAGISGESASLPTQPHPDVSESTMDRDKVGIPTDGDSHAITYPPAIVVYIIDPFTYENKDESTNSSNVWTLGLLRCFLEMVQTLPPHIKSTVSVQIVPCQYLLQPVKHDDRQIYSQHLKSLAFSVFTQCRRPLPTSTNVKTLTGFGPGLAMETALKSPDRPECIRLYTPPFILAPVKDKQTELGETFGEAGQKYNVLFVGYCLSHDQRWILASCTDLYGELLETCIINIDVPNRARRKKGSARRFGLQKLWEWCLGLVQMSSLPWRVVIGRLGRIGHGELKDWSCLLSRRNLQSLSKRLKDMCRMCGISAADSPSILSACLVAMEPQGSFVIMPDSVSTGSVFGRSTTLNMQTPQLNTPQDTSCTHILVFPTSASVQVASATYTTENLDLAFNPNNDGADGMGIFDLLDTGDDLDPDIINILPASPTASPVHSPGSHYPHGGDAGKGQGTDRLLSTESHDEVTNILQQPLALGYFVSTAKAGPLPDWFWSACPQAQYQCPLFLKASLHLHVPSVQSDELLHSKHSHPLDSNQTSDVLRFVLEQYNALSWLTCDPAVQDRRSCLPVHFVVLNQLYNFIMNML DIP protein Q5SWW4 original sequence version: 89 FD54462F5DC387B9 cdk8_human Cyclin-dependent kinase 8 CDK8 Cell division protein kinase 8 Mediator of RNA polymerase II transcription subunit CDK8 Mediator complex subunit CDK8 Protein kinase K35 protein protein human Homo sapiens Human MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY DIP protein P49336 original sequence version: 126 DIP protein P49336 original sequence version: 115 DIP protein P49336 original sequence version: 89 DIP protein P49336-1 original sequence version: 149 DIP protein P49336 original sequence version: 138 00CBAB6CE354605F notc1_human Neurogenic locus notch homolog protein 1 Translocation-associated notch protein TAN-1 NOTCH1 TAN1 protein protein human Homo sapiens Human MPPLLAPLLCLALLPALAARGPRCSQPGETCLNGGKCEAANGTEACVCGGAFVGPRCQDPNPCLSTPCKNAGTCHVVDRRGVADYACSCALGFSGPLCLTPLDNACLTNPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFEASYICHCPPSFHGPTCRQDVNECGQKPGLCRHGGTCHNEVGSYRCVCRATHTGPNCERPYVPCSPSPCQNGGTCRPTGDVTHECACLPGFTGQNCEENIDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFHGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECSLGANPCEHAGKCINTLGSFECQCLQGYTGPRCEIDVNECVSNPCQNDATCLDQIGEFQCICMPGYEGVHCEVNTDECASSPCLHNGRCLDKINEFQCECPTGFTGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCRPGYTGHHCETNINECSSQPCRHGGTCQDRDNAYLCFCLKGTTGPNCEINLDDCASSPCDSGTCLDKIDGYECACEPGYTGSMCNINIDECAGNPCHNGGTCEDGINGFTCRCPEGYHDPTCLSEVNECNSNPCVHGACRDSLNGYKCDCDPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCLLPYTGATCEVVLAPCAPSPCRNGGECRQSEDYESFSCVCPTGWQGQTCEVDINECVLSPCRHGASCQNTHGGYRCHCQAGYSGRNCETDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFRGTFCEEDINECASDPCRNGANCTDCVDSYTCTCPAGFSGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQHDVNECDSQPCLHGGTCQDGCGSYRCTCPQGYTGPNCQNLVHWCDSSPCKNGGKCWQTHTQYRCECPSGWTGLYCDVPSVSCEVAAQRQGVDVARLCQHGGLCVDAGNTHHCRCQAGYTGSYCEDLVDECSPSPCQNGATCTDYLGGYSCKCVAGYHGVNCSEEIDECLSHPCQNGGTCLDLPNTYKCSCPRGTQGVHCEINVDDCNPPVDPVSRSPKCFNNGTCVDQVGGYSCTCPPGFVGERCEGDVNECLSNPCDARGTQNCVQRVNDFHCECRAGHTGRRCESVINGCKGKPCKNGGTCAVASNTARGFICKCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGPFTGPECQFPASSPCLGGNPCYNQGTCEPTSESPFYRCLCPAKFNGLLCHILDYSFGGGAGRDIPPPLIEEACELPECQEDAGNKVCSLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQRAEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVVVVLMPPEQLRNSSFHFLRELSRVLHTNVVFKRDAHGQQMIFPYYGREEELRKHPIKRAAEGWAAPDALLGQVKASLLPGGSEGGRRRRELDPMDVRGSIVYLEIDNRQCVQASSQCFQSATDVAAFLGALASLGSLNIPYKIEAVQSETVEPPPPAQLHFMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLDDQTDHRQWTQQHLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILIRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNREETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGAPLGGTPTLSPPLCSPNGYLGSLKPGVQGKKVRKPSSKGLACGSKEAKDLKARRKKSQDGKGCLLDSSGMLSPVDSLESPHGYLSDVASPPLLPSPFQQSPSVPLNHLPGMPDTHLGIGHLNVAAKPEMAALGGGGRLAFETGPPRLSHLPVASGTSTVLGSSSGGALNFTVGGSTSLNGQCEWLSRLQSGMVPNQYNPLRGSVAPGPLSTQAPSLQHGMVGPLHSSLAASALSQMMSYQGLPSTRLATQPHLVQTQQVQPQNLQMQQQNLQPANIQQQQSLQPPPPPPQPHLGVSSAASGHLGRSFLSGEPSQADVQPLGPSSLAVHTILPQESPALPTSLPSSLVPPVTAAQFLTPPSQHSYSSPVDNTPSHQLQVPEHPFLTPSPESPDQWSSSSPHSNVSDWSEGVSSPPTSMQSQIARIPEAFK DIP protein P46531 original sequence version: 173 DIP protein P46531 original sequence version: 103 DIP protein P46531 original sequence version: 109 DIP protein P46531 original sequence version: 127 DIP protein P46531 original sequence version: 137 DIP protein P46531 original sequence version: 186 DIP protein P46531 original sequence version: 150 DIP protein P46531 original sequence version: 142 DIP protein P46531 original sequence version: 181 E173C872D195F028 ccnc_human Cyclin-C CCNC SRB11 homolog protein protein human Homo sapiens Human MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS DIP protein P24863 original sequence version: 150 DIP protein P24863 original sequence version: 141 DIP protein P24863 original sequence version: 97 DIP protein P24863-1 original sequence version: 159 DIP protein P24863 original sequence version: 147 CF8AC5E94E621F4C notc1_mouse Neurogenic locus notch homolog protein 1 Notch1 Motch Motch A p300 mT14 protein protein mouse Mus musculus Mouse MPRLLTPLLCLTLLPALAARGLRCSQPSGTCLNGGRCEVANGTEACVCSGAFVGQRCQDSNPCLSTPCKNAGTCHVVDHGGTVDYACSCPLGFSGPLCLTPLDNACLANPCRNGGTCDLLTLTEYKCRCPPGWSGKSCQQADPCASNPCANGGQCLPFESSYICRCPPGFHGPTCRQDVNECSQNPGLCRHGGTCHNEIGSYRCACRATHTGPHCELPYVPCSPSPCQNGGTCRPTGDTTHECACLPGFAGQNCEENVDDCPGNNCKNGGACVDGVNTYNCRCPPEWTGQYCTEDVDECQLMPNACQNGGTCHNTHGGYNCVCVNGWTGEDCSENIDDCASAACFQGATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAICTCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGPRCEIDVNECISNPCQNDATCLDQIGEFQCICMPGYEGVYCEINTDECASSPCLHNGHCMDKINEFQCQCPKGFNGHLCQYDVDECASTPCKNGAKCLDGPNTYTCVCTEGYTGTHCEVDIDECDPDPCHYGSCKDGVATFTCLCQPGYTGHHCETNINECHSQPCRHGGTCQDRDNSYLCLCLKGTTGPNCEINLDDCASNPCDSGTCLDKIDGYECACEPGYTGSMCNVNIDECAGSPCHNGGTCEDGIAGFTCRCPEGYHDPTCLSEVNECNSNPCIHGACRDGLNGYKCDCAPGWSGTNCDINNNECESNPCVNGGTCKDMTSGYVCTCREGFSGPNCQTNINECASNPCLNQGTCIDDVAGYKCNCPLPYTGATCEVVLAPCATSPCKNSGVCKESEDYESFSCVCPTGWQGQTCEVDINECVKSPCRHGASCQNTNGSYRCLCQAGYTGRNCESDIDDCRPNPCHNGGSCTDGINTAFCDCLPGFQGAFCEEDINECASNPCQNGANCTDCVDSYTCTCPVGFNGIHCENNTPDCTESSCFNGGTCVDGINSFTCLCPPGFTGSYCQYDVNECDSRPCLHGGTCQDSYGTYKCTCPQGYTGLNCQNLVRWCDSAPCKNGGRCWQTNTQYHCECRSGWTGVNCDVLSVSCEVAAQKRGIDVTLLCQHGGLCVDEGDKHYCHCQAGYTGSYCEDEVDECSPNPCQNGATCTDYLGGFSCKCVAGYHGSNCSEEINECLSQPCQNGGTCIDLTNSYKCSCPRGTQGVHCEINVDDCHPPLDPASRSPKCFNNGTCVDQVGGYTCTCPPGFVGERCEGDVNECLSNPCDPRGTQNCVQRVNDFHCECRAGHTGRRCESVINGCRGKPCKNGGVCAVASNTARGFICRCPAGFEGATCENDARTCGSLRCLNGGTCISGPRSPTCLCLGSFTGPECQFPASSPCVGSNPCYNQGTCEPTSENPFYRCLCPAKFNGLLCHILDYSFTGGAGRDIPPPQIEEACELPECQVDAGNKVCNLQCNNHACGWDGGDCSLNFNDPWKNCTQSLQCWKYFSDGHCDSQCNSAGCLFDGFDCQLTEGQCNPLYDQYCKDHFSDGHCDQGCNSAECEWDGLDCAEHVPERLAAGTLVLVVLLPPDQLRNNSFHFLRELSHVLHTNVVFKRDAQGQQMIFPYYGHEEELRKHPIKRSTVGWATSSLLPGTSGGRQRRELDPMDIRGSIVYLEIDNRQCVQSSSQCFQSATDVAAFLGALASLGSLNIPYKIEAVKSEPVEPPLPSQLHLMYVAAAAFVLLFFVGCGVLLSRKRRRQHGQLWFPEGFKVSEASKKKRREPLGEDSVGLKPLKNASDGALMDDNQNEWGDEDLETKKFRFEEPVVLPDLSDQTDHRQWTQQHLDAADLRMSAMAPTPPQGEVDADCMDVNVRGPDGFTPLMIASCSGGGLETGNSEEEEDAPAVISDFIYQGASLHNQTDRTGETALHLAARYSRSDAAKRLLEASADANIQDNMGRTPLHAAVSADAQGVFQILLRNRATDLDARMHDGTTPLILAARLAVEGMLEDLINSHADVNAVDDLGKSALHWAAAVNNVDAAVVLLKNGANKDMQNNKEETPLFLAAREGSYETAKVLLDHFANRDITDHMDRLPRDIAQERMHHDIVRLLDEYNLVRSPQLHGTALGGTPTLSPTLCSPNGYLGNLKSATQGKKARKPSTKGLACGSKEAKDLKARRKKSQDGKGCLLDSSSMLSPVDSLESPHGYLSDVASPPLLPSPFQQSPSMPLSHLPGMPDTHLGISHLNVAAKPEMAALAGGSRLAFEPPPPRLSHLPVASSASTVLSTNGTGAMNFTVGAPASLNGQCEWLPRLQNGMVPSQYNPLRPGVTPGTLSTQAAGLQHSMMGPLHSSLSTNTLSPIIYQGLPNTRLATQPHLVQTQQVQPQNLQLQPQNLQPPSQPHLSVSSAANGHLGRSFLSGEPSQADVQPLGPSSLPVHTILPQESQALPTSLPSSMVPPMTTTQFLTPPSQHSYSSSPVDNTPSHQLQVPEHPFLTPSPESPDQWSSSSPHSNISDWSEGISSPPTTMPSQITHIPEAFK DIP protein Q01705 original sequence version: 161 DIP protein Q01705 original sequence version: 102 DIP protein Q01705-1 original sequence version: 137 DIP protein Q01705-1 original sequence version: 126 DIP protein Q01705 original sequence version: 169 97C91F69BABF02BF cdk2_mouse Cyclin-dependent kinase 2 Cdk2 Cell division protein kinase 2 Cdkn2 protein protein mouse Mus musculus Mouse MENFQKVEKIGEGTYGVVYKAKNKLTGEVVALKKIRLDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTENKLYLVFEFLHQDLKKFMDASALTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINAEGSIKLADFGLARAFGVPVRTYTHEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMHLVCTQHHAKCCGEHRRNGRHSLCPLCSYLEVAASQGGGMTAVSAPHPVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLDEDGRSLLSQMLHYDPNKRISAKAALAHPFFQDVTKPVPHLRL DIP protein P97377 original sequence version: 140 D806BC2F150AEDFC ccnc_mouse Cyclin-C Ccnc protein protein mouse Mus musculus Mouse MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQVIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAATTSVLKTRFSYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDVLLPLAWRIVNDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQWKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS DIP protein Q62447 original sequence version: 114 DE2065E2E4C304FC cdk8_mouse Cyclin-dependent kinase 8 Cdk8 Cell division protein kinase 8 Mediator complex subunit CDK8 Mediator of RNA polymerase II transcription subunit CDK8 protein protein mouse Mus musculus Mouse MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGISMSACREIALLRELKHPNVISLLKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKPVQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLFNSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQEDIKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKHKVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLTEEEPDEKGDKKTQQQQQGNNHTNGTGHPGNQDSGHAQGPPLKKVRVVPPTTTSGGLIMTSDYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY DIP protein Q8R3L8 original sequence version: 65 DIP protein Q8R3L8 original sequence version: 101 D8E350486ADA3F8D ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG cdk1_mouse Cyclin-dependent kinase 1 p34 protein kinase Cell division protein kinase 1 Cdk1 Cdc2a Cdc2 Cell division control protein 2 homolog Cdkn1 protein protein mouse Mus musculus Mouse MEDYIKIEKIGEGTYGVVYKGRHRVTGQIVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQFMDSSLVKSYLHQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLVYDPAKRISGKMALKHPYFDDLDNQIKKM DIP protein P11440 original sequence version: 149 DIP protein P11440 original sequence version: 164 9C399FCC41BA7F31 fbxw7_mouse F-box/WD repeat-containing protein 7 Fbxw7 Fbw7 Fbwd6 Fbxw6 F-box and WD-40 domain-containing protein 7 F-box protein FBW7 F-box protein Fbxw6 F-box-WD40 repeat protein 6 SEL-10 protein protein mouse Mus musculus Mouse MNQELLSVGSKRRRTGGSLRGNASSSQVDEGQMNRVVEEDPQQQARHQEEEHTARNGELVGANPRPGDQNDTQQGQVEENNNRFISVDEDSSGNQEEQEEDEEHAGEQEEEEEEEEEEEEMDQESDDFDPSDDSSREDEHTHNSNVTNCSSVSDLPAHQLSSPFYTKTTKMKRKLDHGSEVRSFSLGKKPCKVSDYTSTTGLVPCSATPTTFGDLRAANGQGQQRRRITSVQPPTGLQEWLKMFQSWSGPEKLLALDELIDSCEPTQVKHMMQVIEPQFQRDFISLLPKELALYVLSFLEPKDLLQAAQTCRYWRILAEDNLLWREKCKEEGIDEPLHIKRRKIIKPGFIHSPWKSAYIRQHRIDTNWRRGELKSPKVLKGHDDHVITCLQFCGNRIVSGSDDNTLKVWSAVTGKCLRTLVGHTGGVWSSQMRDNIIISGSTDRTLKVWNAETGECIHTLYGHTSTVRCMHLHEKRVVSGSRDATLRVWDIETGQCLHVLMGHVAAVRCVQYDGRRVVSGAYDFMVKVWDPETETCLHTLQGHTNRVYSLQFDGIHVVSGSLDTSIRVWDVETGNCIHTLTGHQSLTSGMELKDNILVSGNADSTVKIWDIKTGQCLQTLQGPSKHQSAVTCLQFNKNFVITSSDDGTVKLWDLKTGEFIRNLVTLESGGSGGVVWRIRASNTKLVCAVGSRNGTEETKLLVLDFDVDMK DIP protein Q8VBV4 original sequence version: 113 DIP protein Q8VBV4 original sequence version: 118 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins. Involved in the degradation of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1 mint 9D56F7E81E6E390B ccnc-med12-3 3 17 unspecified role unspecified role prey prey mouse Mus musculus Mouse 27 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association hub-notch1-1 4 29 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal human Homo sapiens Human 23 unspecified role unspecified role prey prey Region 1754-2555 Region 1754-2555 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association cdk8-med12-3 5 28 unspecified role unspecified role bait bait mouse Mus musculus Mouse 17 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association ccnc-cdk19-1 7 18 unspecified role unspecified role prey prey human Homo sapiens Human 19 unspecified role unspecified role prey prey human Homo sapiens Human 22 unspecified role unspecified role prey prey human Homo sapiens Human 24 unspecified role unspecified role bait bait human Homo sapiens Human association association notch1-fbxw7-2 10 20 unspecified role unspecified role prey prey 35S-label 35S-label 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined in vitro In vitro 23 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range Region 1754-2555 Region 1754-2555 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli physical association physical association med12-cdk8-1 8 28 unspecified role unspecified role prey prey mouse Mus musculus Mouse 17 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association mub-notch1-1 13 25 unspecified role unspecified role prey prey mouse Mus musculus Mouse 16 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association notch1-fbxw7-3 14 20 unspecified role unspecified role prey prey human Homo sapiens Human 23 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association med13-cdk8-1 1 21 unspecified role unspecified role bait bait mouse Mus musculus Mouse 28 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association notch1-fbxw7-4 9 31 unspecified role unspecified role prey prey mouse Mus musculus Mouse 23 unspecified role unspecified role bait bait Region 1754-2555 Region 1754-2555 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range mouse Mus musculus Mouse physical association physical association notch1-fbxw7-5 11 20 unspecified role unspecified role prey prey human Homo sapiens Human 23 unspecified role unspecified role bait bait Region 1754-2555 Region 1754-2555 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P46531:p.Pro2514Arg P2514R mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain P R This feature has been corrected as a result of our quality control procedures. The original label was 'P2514R'. Wed May 02 18:02:29 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro2514arg' Tue Jun 30 15:54:07 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro2514Arg' Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association cdk1-ccnc-1 2 27 unspecified role unspecified role prey prey mouse Mus musculus Mouse 30 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association notch1-fbxw7-6 12 20 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 23 unspecified role unspecified role bait bait Region 1754-2555 Region 1754-2555 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P46531:p.[Thr2511Ala;Ser2513Ala;Ser2516Ala] T2511A/S2513A/S2516A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain T A This feature has been corrected as a result of our quality control procedures. The original label was 'T2511A/S2513A/S2516A'. Wed May 02 20:17:31 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr2511ala,ser2513ala,ser2516ala' Tue Jun 30 17:42:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Thr2511Ala;Ser2513Ala;Ser2516Ala]' Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range P46531:p.Thr2511Ala T2511A mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain T A This feature has been corrected as a result of our quality control procedures. The original label was 'T2511A'. Wed May 02 16:29:49 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr2511ala' Tue Jun 30 16:13:01 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr2511Ala' P46531:p.[Ser2513Ala;Ser2516Ala] S2513A/S2516A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain S A certain certain sequence position certain certain certain sequence position certain S A This feature has been corrected as a result of our quality control procedures. The original label was 'S2513A/S2516A'. Wed May 02 17:40:39 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser2513ala,ser2516ala' Tue Jun 30 18:34:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Ser2513Ala;Ser2516Ala]' human Homo sapiens Human physical association physical association fbxw7-notch1-2 15 20 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 23 unspecified role unspecified role prey prey P46531:p.Pro2512Leu mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength certain certain sequence position certain certain certain sequence position certain P L Wed May 02 20:21:24 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro2512leu' Tue Jun 30 18:43:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro2512Leu' Region 1754-2555 Region 1754-2555 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P46531:p.Pro2514Arg P2514R mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain P R This feature has been corrected as a result of our quality control procedures. The original label was 'P2514R'. Wed May 02 18:30:53 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro2514arg' Tue Jun 30 15:51:48 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro2514Arg' Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range P46531:p.Pro2512Ala P2512A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P2512A'. Wed May 02 16:10:22 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro2512ala' Tue Jun 30 18:40:28 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro2512Ala' P46531:p.Pro2512Ser P2512S/L mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain P S Wed May 02 16:12:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro2512ser' Tue Jun 30 16:24:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Pro2512Ser' P46531:p.Ser2513Phe S2513F mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain S F This feature has been corrected as a result of our quality control procedures. The original label was 'S2513F'. Wed May 02 15:05:56 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ser2513phe' Tue Jun 30 18:35:10 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ser2513Phe' human Homo sapiens Human physical association physical association cdk2-ccnc-1 6 26 unspecified role unspecified role bait bait mouse Mus musculus Mouse 27 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association