DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Nature 2015 imex curation Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. DIP original experiment: DIP-265260X Nature 2015 IMEx Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Nature 2015 imex curation Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. DIP original experiment: DIP-265259X Nature 2015 IMEx Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. Nature 2015 imex curation Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip predetermined predetermined participant predetermined Zhang X., Bogunovic D., Payelle-Brogard B., Francois-Newton V., Speer SD., Yuan C., Volpi S., Li Z., Sanal O., Mansouri D., Tezcan I., Rice GI., Chen C., Mansouri N., Mahdaviani SA., Itan Y., Boisson B., Okada S., Zeng L., Wang X., Jiang H., Liu W., Han T., Liu D., Ma T., Wang B., Liu M., Liu JY., Wang QK., Yalnizoglu D., Radoshevich L., Uzé G., Gros P., Rozenberg F., Zhang SY., Jouanguy E., Bustamante J., García-Sastre A., Abel L., Lebon P., Notarangelo LD., Crow YJ., Boisson-Dupuis S., Casanova JL., Pellegrini S. DIP original experiment: DIP-265261X Nature 2015 IMEx Human intracellular ISG15 prevents interferon-α/β over-amplification and auto-inflammation. ubp18_human Ubl carboxyl-terminal hydrolase 18 USP18 ISG43 ISG15-specific-processing protease 43 kDa ISG15-specific protease Ubl thioesterase 18 protein protein human Homo sapiens Human MSKAFGLLRQICQSILAESSQSPADLEEKKEEDSNMKREQPRERPRAWDYPHGLVGLHNIGQTCCLNSLIQVFVMNVDFTRILKRITVPRGADEQRRSVPFQMLLLLEKMQDSRQKAVRPLELAYCLQKCNVPLFVQHDAAQLYLKLWNLIKDQITDVHLVERLQALYTIRVKDSLICVDCAMESSRNSSMLTLPLSLFDVDSKPLKTLEDALHCFFQPRELSSKSKCFCENCGKKTRGKQVLKLTHLPQTLTIHLMRFSIRNSQTRKICHSLYFPQSLDFSQILPMKRESCDAEEQSGGQYELFAVIAHVGMADSGHYCVYIRNAVDGKWFCFNDSNICLVSWEDIQCTYGNPNYHWQETAYLLVYMKMEC DIP protein Q9UMW8 original sequence version: 131 60248E8D4CC42BF0 ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG isg15_human Ubiquitin-like protein ISG15 ISG15 G1P2 UCRP Interferon-induced 15 kDa protein Interferon-induced 17 kDa protein Ubiquitin cross-reactive protein protein protein human Homo sapiens Human MGWDLTVKMLAGNEFQVSLSSSMSVSELKAQITQKIGVHAFQQRLAVHPSGVALQDRVPLASQGLGPGSTVLLVVDKCDEPLSILVRNNKGRSSTYEVRLTQTVAHLKQQVSGLEGVQDDLFWLTFEGKPLEDQLPLGEYGLKPLSTVFMNLRLRGGGTEPGGRS DIP protein P05161 original sequence version: 130 DIP protein P05161 original sequence version: 142 DIP protein P05161 original sequence version: 155 DIP protein P05161 original sequence version: 96 DIP protein P05161 original sequence version: 141 DIP protein P05161 original sequence version: 168 DIP protein P05161 original sequence version: 150 B6858A15AB0FFFDE q13309-1 S-phase kinase-associated protein 2 Cyclin-A/CDK2-associated protein p45 F-box protein Skp2 F-box/LRR-repeat protein 1 p45skp2 SKP2-alpha SKP2 FBXL1 protein protein human Homo sapiens Human MHRKHLQEIPDLSSNVATSFTWGWDSSKTSELLSGMGVSALEKEEPDSENIPQELLSNLGHPESPPRKRLKSKGSDKDFVIVRRPKLNRENFPGVSWDSLPDELLLGIFSCLCLPELLKVSGVCKRWYRLASDESLWQTLDLTGKNLHPDVTGRLLSQGVIAFRCPRSFMDQPLAEHFSPFRVQHMDLSNSVIEVSTLHGILSQCSKLQNLSLEGLRLSDPIVNTLAKNSNLVRLNLSGCSGFSEFALQTLLSSCSRLDELNLSWCFDFTEKHVQVAVAHVSETITQLNLSGYRKNLQKSDLSTLVRRCPNLVHLDLSDSVMLKNDCFQEFFQLNYLQHLSLSRCYDIIPETLLELGEIPTLKTLQVFGIVPDGTLQLLKEALPHLQINCSHFTTIARPTIGNKKNQEIWGIKCRLTLQKPSCL DIP protein Q13309-1 original sequence version: 154 DIP protein Q13309-1 original sequence version: 104 DIP protein Q13309 original sequence version: 105 DIP protein Q13309 original sequence version: 153 DIP protein Q13309 original sequence version: 151 usp18-ub-1 2 5 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal human Homo sapiens Human 4 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association usp18-skp2-1 1 7 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 4 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association usp18-isg15-4 3 6 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 4 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association