DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Structure (London, England : 1993) 2014 imex curation Rennie ML., McKelvie SA., Bulloch EM., Kingston RL. Only protein-protein interactions in vitro In vitro sls static light scattering sls predetermined predetermined participant predetermined Rennie ML., McKelvie SA., Bulloch EM., Kingston RL. DIP original experiment: DIP-262301X Structure (London, England : 1993) 2014 IMEx Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Structure (London, England : 1993) 2014 imex curation Rennie ML., McKelvie SA., Bulloch EM., Kingston RL. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Rennie ML., McKelvie SA., Bulloch EM., Kingston RL. DIP original experiment: DIP-262303X Structure (London, England : 1993) 2014 IMEx Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Structure (London, England : 1993) 2014 imex curation Rennie ML., McKelvie SA., Bulloch EM., Kingston RL. Only protein-protein interactions in vitro In vitro gtpase assay gtpase assay GTPase gtp hydrolisis gtp hydrolisis GTPase predetermined predetermined participant predetermined Rennie ML., McKelvie SA., Bulloch EM., Kingston RL. DIP original experiment: DIP-262305X Structure (London, England : 1993) 2014 IMEx Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Structure (London, England : 1993) 2014 imex curation Rennie ML., McKelvie SA., Bulloch EM., Kingston RL. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Rennie ML., McKelvie SA., Bulloch EM., Kingston RL. DIP original experiment: DIP-262302X Structure (London, England : 1993) 2014 IMEx Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. Structure (London, England : 1993) 2014 imex curation Rennie ML., McKelvie SA., Bulloch EM., Kingston RL. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Rennie ML., McKelvie SA., Bulloch EM., Kingston RL. DIP original experiment: DIP-262304X Structure (London, England : 1993) 2014 IMEx Transient dimerization of human MxA promotes GTP hydrolysis, resulting in a mechanical power stroke. mx1_human Interferon-induced GTP-binding protein Mx1 MX1 Myxovirus resistance protein 1 Interferon-regulated resistance GTP-binding protein MxA Interferon-induced protein p78 Myxoma resistance protein 1 protein protein human Homo sapiens Human MVVSEVDIAKADPAAASHPLLLNGDATVAQKNPGSVAENNLCSQYEEKVRPCIDLIDSLRALGVEQDLALPAIAVIGDQSSGKSSVLEALSGVALPRGSGIVTRCPLVLKLKKLVNEDKWRGKVSYQDYEIEISDASEVEKEINKAQNAIAGEGMGISHELITLEISSRDVPDLTLIDLPGITRVAVGNQPADIGYKIKTLIKKYIQRQETISLVVVPSNVDIATTEALSMAQEVDPEGDRTIGILTKPDLVDKGTEDKVVDVVRNLVFHLKKGYMIVKCRGQQEIQDQLSLSEALQREKIFFENHPYFRDLLEEGKATVPCLAEKLTSELITHICKSLPLLENQIKETHQRITEELQKYGVDIPEDENEKMFFLIDKVNAFNQDITALMQGEETVGEEDIRLFTRLRHEFHKWSTIIENNFQEGHKILSRKIQKFENQYRGRELPGFVNYRTFETIVKQQIKALEEPAVDMLHTVTDMVRLAFTDVSIKNFEEFFNLHRTAKSKIEDIRAEQEREGEKLIRLHFQMEQIVYCQDQVYRGALQKVREKELEEEKKKKSWDFGAFQSSSATDSSMEEIFQHLMAYHQEASKRISSHIPLIIQFFMLQTYGQQLQKAMLQLLQDKDTYSWLLKERSDTSDKRKFLKERLARLTQARRRLAQFPG DIP protein P20591 original sequence version: 93 DIP protein P20591-1 original sequence version: 137 626A7DD946F89384 mx1-4 1 6 unspecified role unspecified role unspecified role unspecified role Region 37-366/637-662 Region 37-366/637-662 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mx1-5 5 6 unspecified role unspecified role unspecified role unspecified role Region 43-361/641-662 Region 43-361/641-662 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mx1-6 3 6 unspecified role unspecified role unspecified role unspecified role Region 37-366/637-662 Region 37-366/637-662 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mx1-7 4 6 unspecified role unspecified role unspecified role unspecified role Region 37-366/637-662 Region 37-366/637-662 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction mx1-8 2 6 unspecified role unspecified role unspecified role unspecified role Region 37-364/632-662 Region 37-364/632-662 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain certain certain sequence position certain ecolx Escherichia coli direct interaction direct interaction