DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science (New York, N.Y.) 2014 imex curation Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. DIP original experiment: DIP-265046X Science (New York, N.Y.) 2014 IMEx Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science (New York, N.Y.) 2014 imex curation Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. DIP original experiment: DIP-265048X Science (New York, N.Y.) 2014 IMEx Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science (New York, N.Y.) 2014 imex curation Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. DIP original experiment: DIP-265047X Science (New York, N.Y.) 2014 IMEx Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science (New York, N.Y.) 2014 imex curation Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. DIP original experiment: DIP-265051X Science (New York, N.Y.) 2014 IMEx Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science (New York, N.Y.) 2014 imex curation Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. DIP original experiment: DIP-265050X Science (New York, N.Y.) 2014 IMEx Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. Science (New York, N.Y.) 2014 imex curation Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Zuryn S., Ahier A., Portoso M., White ER., Morin MC., Margueron R., Jarriault S. DIP original experiment: DIP-265049X Science (New York, N.Y.) 2014 IMEx Transdifferentiation. Sequential histone-modifying activities determine the robustness of transdifferentiation. jmj31_caeel Lysine-specific demethylase jmjd-3.1 jmjd-3.1 JmjC domain-containing protein 3.1 F18E9.5 protein protein caeel Caenorhabditis elegans MQGKNSHLTGITGTTHFTIFGASPRSMSLVKNSQETPPFPGMNSTMRPVEFNSTKQPEAQTIDQEQDAPKSFDFKNQTLGVYSDTVLNPLKNDSFKDELVVDVQKNLPIESLTVSPKSSTDQNCRSTNEAIRIAGFDNFADQLQESNGVFEACPEAHSEQGNESEDFKDLINSETECNIEDVVLPTVHVSTDSEEIISGDVIMNDSNVVSKPKNLEKVETPDVLIGSGSNDKLSDMTEQIGNNQHLEKLISEKTEKSLSDNETTLKPVPVQHTNSVGSSIGTTSGDSEISDDDQKSWSPKNESLDYQPASTSSEFTETTSVANQTESNAGSVDDYCPRTSIDIGLDSSAPSCSSDATREPTPIKKRGRKKKEQSATEPPIPRTKRAYTKNPNTIRKRRMKKNQSDDEEDDGPPKRRTINYQIEFRDASGAWTMAQQLIFVRDFMSKKNDKIVKLSKSRQDRVDKFILQFQKTQDSHYMRAAIQLNTIFPDQGNYRHCQDYLKDLTIRVVVPPKRREGKRKSEVPANPPALLLTGPLYLNFYCTSQEVLEAAGQLLEFHVNAVYKDERLQPPVADKTLLDLERAMYHEQVKDLTDYHKYRIPCPTLTVTTKEEVFSSDFERILNSASITNISGIAKALNIKTELFSLPEIAKCHPELSIDILNQVPQSADGNCDSKGIRCWDVTSYSSKMKLQDFERYMQKEESEAMQAFETISNCTAKELESTCQKLKAERIAAQNAIEGCDETMPWIKFGTNIDLLSENFKKQMNEIEKLPTFLLPNREGNLLNYAGVDVLGINTVQMYAKPIGSRTPAHMENSLMASINWNRGPGTCVWFAVPYEYWGQLEFMIGEHGHKYQDQDYWPSEKELLELGVPVIKFEQKADEMVYVNTGCFHWVQSNSFCINVSWNVGQPNFTQLATSIVAHDHNMLIGNQAHVPLVNLVWNAARQRLFVDDPEMYKAMRGVMIRSLAHSKWYFDLIDHHDYIVGDASEWKLADRVQRCKYCTSEIFNIVRWYTTEDLSVDSYPFCSHCHVANEYKKDRFLKYTWFFSLETLVNIFDAYVPN DIP protein Q95QK3 original sequence version: 89 egl27_caeel Egg-laying defective protein 27 egl-27 C04A2.3 protein protein caeel Caenorhabditis elegans MSRFDSQCSSEDVNKEDECVPSSSEDSQDGVSSPMENDDEPEFSQKHYDIEPCYYSLTGKSDRNCRGIVYRYRQDSDLKGFQSHDGTLYRLRDSVFVEVSQNEPYVIAAICGFKYTKRDHVVVKLTRYFRADDIPEISLNLMKQERAELEINPHLCPQSLNRELFNSELQITQPVSCLRGKCIVEYVKDVRHARTVADFSLDNDTFFFCLHYNQDSTKLASTHYAIRVGTSFQATLPPMAECSVGDDSDRDELLYRPNSIESGEEEDYIKLARCYRTYTLSGNHMLDSQKNARSLQVSDLLMDEAIIQLHRSGYKIDDALSELNANDIILTTDVDNMTQDDAKKFAKGIKQLGKNFSRIHRELLPHHSREQLVSYYYLWKKTPEATKPKQAARRVNPTSIKRPTKEKVKASRPTSTEYLDFDSASESDVENNGPSGRACHHCYGAESKDWHHANGLLLCTDCRLHYKKYGQLRQIANRPSQVPACLFKRSNSDEEESGVRTRAGKKEQRRRTPSSMSETPDRRSPSTVSNGAPNLTAEETPTKKLNGSVKRAPKRPLHNGVINNVEKSNSSEEPASPTTPPPTLTNGLTNGHGPESSTPNGETISKRMKVEPSYDDDDDEEEGKMTIDEGDDDPMPVLNGFKKEESVEEIKLELNGTIKKENGVETDPTTPTCSMEAENEVCETPAVVSVEIRDETNGETNSDLKDDENVEPDSPEDTFELGSNVEFETKNAMFVRSIVRSCGPRCARTDLIFKIKVGGVWEKSIKEKEERKKVHLQNQRIQDSEKVAIQQNQIKKEQQQSQPTPQQIHQQQAQQNAQHLQQLQQAVMLGHLPPEVLRQMMPPQFGVDPTAILMQQMMAGQQSQGVNAAFQHQMALQQQLEAHQVQFQLMMAHQHQQKMIAEQQQQQRHAAAQQLREREQREQRERERERQHQQQAQQALHQQQQQHAAAAANQLNPAMMQMMALMANSAASQQDIARLMEMAAQQQQQQQQAAQAQAQRDQERERREREAREREAAREREREQAAREAAARDQAAREHAQAVQAAAAAAQQAQALTPDMQHMHLLQQLMLNPALMMQLQQAQAQQQQQQPQVTNPLQMLQHGMAAQSANQAEMMRRIHPEPAMRPQHQ DIP protein Q09228 original sequence version: 116 DIP protein Q09228 original sequence version: 114 6E0F88BBC0AF43E8 wdr51_caeel WD repeat-containing protein wdr-5.1 wdr-5.1 swd-3.1 tag-125 C14B1.4 protein protein caeel Caenorhabditis elegans MDTSENAASAAEQQPTQQIDQLTVPNAPDGGSSAPAPSTSPNSISPSNPTGTPAPGASAQTPNPNAAGASASGSANYKLMCTLEGHTKSISSAKFSPCGKYLGTSSADKTVKIWNMDHMICERTLTGHKLGVNDIAWSSDSRCVVSASDDKTLKIFEIVTSRMTKTLKGHNNYVFCCNFNPQSSLVVSGSFDESVRIWDVKTGMCIKTLPAHSDPVSAVSFNRDGSLIASGSYDGLVRIWDTANGQCIKTLVDDENPPVAFVKFSPNGKYILASNLDSTLKLWDFSKGKTLKQYTGHENSKYCIFANFSVTGGKWIISGSEDCKIYIWNLQTREIVQCLEGHTQPVLASDCHPVQNIIASGALEPDNKIHIWRSDV DIP protein Q17963 original sequence version: 96 3204DC36FE58FC19 unc3_caeel Transcription factor unc-3 unc-3 Uncoordinated protein 3 Y16B4A.1 protein protein caeel Caenorhabditis elegans MSLTAPLRAGQMNFYDEPYNPVLNLHIQPSVKDENQRSTWPIIDTSNTSTQIARAHFEKHPPNNLRKSNFFHFVIALYDRNSQPIEVERTQFAGFVEKEKEVDGQDTRNGIHYRLSLMFQNGIRSEHDLFVRLIDSSTKQAITYEGQDKNPEMCRVLLTHEVMCSRCCEKKSCGNRNETPSDPVIIDRFFLKFFLKCNQNCLKNAGNPRDMRRFQVVLCSSARIDGPLLAVSDNMFVHNNSKHGRRTKRTDASDDSEYSESAELPSSVPVIKALFPSEGWIQGGTQVVLIGENFFEGLQVAFGTASPNWGESVQLISPHAIRVTTPPKHSAGPVDVTLQYKSKTYSRGTPLRFSYITLAEPGIEYGFQRLQKLLPKYPGDPERLPKDQILKRAAELAEALYNRTSTESLSSYYHTQFDATSDYAARTHTSPRSTLPYGAGPPALSSAVYQTSYPTVNATPAANFLNTQTGFATFGAVNPFAATLQSSSRLS DIP protein Q93705 original sequence version: 111 CFC71C132D02D485 g5eff4_caeel sem-4 F15C11.1 CELE_F15C11.1 protein protein caeel Caenorhabditis elegans MNELLAEMAAVSSRRKQSKPRRMSGEGDAMMSPIDLSTKSFDENNCEKGAGGALPLEDRSNILPHFSVPFANPQQFLSLCAQLGNSSSRNVSSTASTTSSCPIQSCSQSFSSPAALTWHVLDAHEDEQEIFSCDVCTTTFSNGQDIREHKCQKTLASRSTSVPPSTIPSSVCFLSTPTTPCLQFSINESIGTSEIREEDEEEDMDVEDGEHVANQLFGHLLQKSDDKSKMASLFNHAFPPFAAFPNMPPPFLMRQPFDPRADVFAAGRHDNDDDWEALMEISTSDEAEKIRALVGDKAVPTTDPNQCILCRRVLSCKSALQMHYRTHTGERPFKCKICQRAFTTKGNLKTHMGVHRSKHSFRGLPISLPPQLAAMHQHQHQIAPPQRIHIHNPPTSAASAAAAVAQIQASQQCPICQQRFLNAGELAVHITEHRNSLTQPPRVMPTPTTTRVQTFPFVPFFTTPPSLNATDMSTQFNLANILSAQLKNDSSPNTDTSSVEEKITRDDPPKMASLSPSNSSDSSSSVRQDILESSEFEEKLKKLEEPPILEQQVSTTPNPKNENPLLAMQKMWAETEPPPPRQMPVLSKHQCGVCFKHFSSSSALQIHMRTHTGDKPFKCDMCGRAFTTRGNLKVHMGTHSWQQSPSRRGRRIFDVASSVTEKPMLQSPILPTSGAPGASPLAMLGPNGLSGLEMMMMLWRTVCSVCQKVCQSPNELEQHLKEHLNNGSSAAPTPLASAATPPPS DIP protein G5EFF4 original sequence version: 31 BCF468C639A30182 sox2_caeel Transcription factor sox-2 sox-2 K08A8.2 protein protein caeel Caenorhabditis elegans MMMDPDSAKMQDYSGWSFGFHMPPTSSTNLLPQSMPDDLSNGPDSPDSTGKDGKKNDDRVKRPMNAFMVWSRGQRKKMALENPKMHNSEISKRLGTEWKMLSEQEKRPFIDEAKRLRAIHMKEHPDYKYRPRRKTKSINKKNGAPIPFGNLDTKTPSYPTLTTNWNATNQYIDQFRFAPYPTTTVMDQIPFSLTYPVHSVPTDNSSPSQFQPSPMSTNFAGSYLTPKSESSPVGSDSTVGTVDSSQFRAYYDHTKDQMMYPYSIELTHAQNIQNALSQSHVTS DIP protein Q21305 original sequence version: 109 71F46FD3BDDAAFA4 hm06_caeel Homeobox protein ceh-6 ceh-6 K02B12.1 protein protein caeel Caenorhabditis elegans MLIPSSSSIPSSLSASASDSEPSSLNGSGISDQNILPNYHLHHHLINENEMEAANYAQVIKPTCEAFQDWPHTPMLYQQPQLHFMLPQHDWAYPHLAQSLPPPHHLTPSTAAVAAATIASQSSIINQTSVVTSTPSCQIKQEVERPEIIQRLMPPWPPAYQFSCDDSGSVSGAGGPHQPLSDISDDSEQTCPDDLEGFAKQFKQRRIKLGYTQADVGVALGTLYGNIFSQTTICRFEALQLSFKNMCKLKPLLFKWLEEADSTTGSPNSTFEKMTGQAGRKRKKRTSIEVNVKSRLEFHFQSNQKPNAQEITQVAMELQLEKEVVRVWFCNRRQKEKRIAPNQYDAPHPMALNNGYPMTADLFPYQAVVNHYTQQSPRQQ DIP protein P20268 original sequence version: 126 46890A452DF90A5E wdr_5.1-sem_4-1 2 11 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 9 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association wdr_5.1-ceh_6-1 1 13 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 9 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association egl_27-wdr_5.1-1 5 8 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 9 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association wdr_5.1-jmjd_3.1-1 6 7 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 9 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association wdr_5.1-sox_2-1 3 12 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 9 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association unc_3-jmjd_3.1-1 4 10 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human 7 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Region 369-759 Region 369-759 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human physical association physical association