DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 2014 imex curation Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. DIP original experiment: DIP-262051X Nature 2014 IMEx Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 2014 imex curation Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. Only protein-protein interactions in vitro In vitro comigration in sds comigration in sds page comigration in sds western blot western blot Immuno blot Immuno blot Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. DIP original experiment: DIP-262053X Nature 2014 IMEx Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 2014 imex curation Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. Only protein-protein interactions in vitro In vitro comigration in sds comigration in sds page comigration in sds predetermined predetermined participant predetermined Fischer ES., Böhm K., Lydeard JR., Yang H., Stadler MB., Cavadini S., Nagel J., Serluca F., Acker V., Lingaraju GM., Tichkule RB., Schebesta M., Forrester WC., Schirle M., Hassiepen U., Ottl J., Hild M., Beckwith RE., Harper JW., Jenkins JL., Thomä NH. DIP original experiment: DIP-262052X Nature 2014 IMEx Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. crbn_chick Protein cereblon CRBN protein protein chick Gallus gallus (Chicken) Chicken MAAEEGGDGRRNMGNPPPPAPAESEEEDDNEMEVEDQDGKEAEKPNMINFDTSLPTSHMYLGSDMEEFHGRTLHDDDSCQVIPVLPHVMVMLIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVREREAHFGTTAEIYAYREEQEYGIETVKVKAIGRQRFKVLEIRTQSDGIQQAKVQILPERVLPSTMSAVQLQSLSRRHIFPSSKPKVWQDRAFRQWWQKYQKRKFHCASLTSWPPWLYSLYDAETLMERVKRQLHEWDENLKDESLPTNPIDFSYRVAACLPIDDALRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQDTEITTKNEIFSLSLCGPMAAYVNPHGYIHETLTVYKACNLNLSGRPSTEHSWFPGYAWTIAQCRICGNHMGWKFTATKKDMSPQKFWGLTRSALLPRIPEAEDELGHDRSPLLCL DIP protein P0CF65 original sequence version: 25 ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG crbn_human Protein cereblon CRBN AD-006 protein protein human Homo sapiens Human MAGEGDQQDAAHNMGNHLPLLPAESEEEDEMEVEDQDSKEAKKPNIINFDTSLPTSHTYLGADMEEFHGRTLHDDDSCQVIPVLPQVMMILIPGQTLPLQLFHPQEVSMVRNLIQKDRTFAVLAYSNVQEREAQFGTTAEIYAYREEQDFGIEIVKVKAIGRQRFKVLELRTQSDGIQQAKVQILPECVLPSTMSAVQLESLNKCQIFPSKPVSREDQCSYKWWQKYQKRKFHCANLTSWPRWLYSLYDAETLMDRIKKQLREWDENLKDDSLPSNPIDFSYRVAACLPIDDVLRIQLLKIGSAIQRLRCELDIMNKCTSLCCKQCQETEITTKNEIFSLSLCGPMAAYVNPHGYVHETLTVYKACNLNLIGRPSTEHSWFPGYAWTVAQCKICASHIGWKFTATKKDMSPQKFWGLTRSALLPTIPDTEDEISPDKVILCL DIP protein Q96SW2 original sequence version: 125 DIP protein Q96SW2 original sequence version: 124 DIP protein Q96SW2 original sequence version: 113 DIP protein Q96SW2-1 original sequence version: 107 DIP protein Q96SW2 original sequence version: 117 90DF77D98A8BEAA8 meis2_human Homeobox protein Meis2 MRG1 Meis1-related protein 1 MEIS2 protein protein human Homo sapiens Human MAQRYDELPHYGGMDGVGVPASMYGDPHAPRPIPPVHHLNHGPPLHATQHYGAHAPHPNVMPASMGSAVNDALKRDKDAIYGHPLFPLLALVFEKCELATCTPREPGVAGGDVCSSDSFNEDIAVFAKQVRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDATSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAGFLLDPSVSQGAAYSPEGQPMGSFVLDGQQHMGIRPAGLQSMPGDYVSQGGPMGMSMAQPSYTPPQMTPHPTQLRHGPPMHSYLPSHPHHPAMMMHGGPPTHPGMTMSAQSPTMLNSVDPNVGGQVMDIHAQ DIP protein O14770 original sequence version: 131 94EBD0801A312B24 ddb1_human DNA damage-binding protein 1 DDB1 Damage-specific DNA-binding protein 1 UV-damaged DNA-binding factor DDB p127 subunit DNA damage-binding protein a UV-damaged DNA-binding protein 1 Xeroderma pigmentosum group E-complementing protein XPE-binding factor HBV X-associated protein 1 XAP1 protein protein human Homo sapiens Human MSYNYVVTAQKPTAVNGCVTGHFTSAEDLNLLIAKNTRLEIYVVTAEGLRPVKEVGMYGKIAVMELFRPKGESKDLLFILTAKYNACILEYKQSGESIDIITRAHGNVQDRIGRPSETGIIGIIDPECRMIGLRLYDGLFKVIPLDRDNKELKAFNIRLEELHVIDVKFLYGCQAPTICFVYQDPQGRHVKTYEVSLREKEFNKGPWKQENVEAEASMVIAVPEPFGGAIIIGQESITYHNGDKYLAIAPPIIKQSTIVCHNRVDPNGSRYLLGDMEGRLFMLLLEKEEQMDGTVTLKDLRVELLGETSIAECLTYLDNGVVFVGSRLGDSQLVKLNVDSNEQGSYVVAMETFTNLGPIVDMCVVDLERQGQGQLVTCSGAFKEGSLRIIRNGIGIHEHASIDLPGIKGLWPLRSDPNRETDDTLVLSFVGQTRVLMLNGEEVEETELMGFVDDQQTFFCGNVAHQQLIQITSASVRLVSQEPKALVSEWKEPQAKNISVASCNSSQVVVAVGRALYYLQIHPQELRQISHTEMEHEVACLDITPLGDSNGLSPLCAIGLWTDISARILKLPSFELLHKEMLGGEIIPRSILMTTFESSHYLLCALGDGALFYFGLNIETGLLSDRKKVTLGTQPTVLRTFRSLSTTNVFACSDRPTVIYSSNHKLVFSNVNLKEVNYMCPLNSDGYPDSLALANNSTLTIGTIDEIQKLHIRTVPLYESPRKICYQEVSQCFGVLSSRIEVQDTSGGTTALRPSASTQALSSSVSSSKLFSSSTAPHETSFGEEVEVHNLLIIDQHTFEVLHAHQFLQNEYALSLVSCKLGKDPNTYFIVGTAMVYPEEAEPKQGRIVVFQYSDGKLQTVAEKEVKGAVYSMVEFNGKLLASINSTVRLYEWTTEKELRTECNHYNNIMALYLKTKGDFILVGDLMRSVLLLAYKPMEGNFEEIARDFNPNWMSAVEILDDDNFLGAENAFNLFVCQKDSAATTDEERQHLQEVGLFHLGEFVNVFCHGSLVMQNLGETSTPTQGSVLFGTVNGMIGLVTSLSESWYNLLLDMQNRLNKVIKSVGKIEHSFWRSFHTERKTEPATGFIDGDLIESFLDISRPKMQEVVANLQYDDGSGMKREATADDLIKVVEELTRIH DIP protein Q16531 original sequence version: 145 DIP protein Q16531 original sequence version: 140 DIP protein Q16531 original sequence version: 99 DIP protein Q16531 original sequence version: 93 DIP protein Q16531 original sequence version: 116 DIP protein Q16531 original sequence version: 111 DIP protein Q16531-1 original sequence version: 163 DIP protein Q16531 original sequence version: 162 DIP protein Q16531 original sequence version: 113 DIP protein Q16531 original sequence version: 132 DIP protein Q16531 original sequence version: 139 DIP protein Q16531 original sequence version: 151 DIP protein Q16531-1 original sequence version: 144 DIP protein Q16531 original sequence version: 155 74D082023E3D846D crbn-ddb1-5 1 4 unspecified role unspecified role unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper 8 unspecified role unspecified role unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction crbn-ub-1 3 5 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 6 unspecified role unspecified role unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper direct interaction direct interaction meis2-ub-1 2 7 unspecified role unspecified role unspecified role unspecified role trini Trichoplusia ni (Cabbage looper) Cabbage looper 5 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction