DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature 2014 imex curation Bingol B., Tea JS., Phu L., Reichelt M., Bakalarski CE., Song Q., Foreman O., Kirkpatrick DS., Sheng M. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Bingol B., Tea JS., Phu L., Reichelt M., Bakalarski CE., Song Q., Foreman O., Kirkpatrick DS., Sheng M. DIP original experiment: DIP-260829X Nature 2014 IMEx The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature 2014 imex curation Bingol B., Tea JS., Phu L., Reichelt M., Bakalarski CE., Song Q., Foreman O., Kirkpatrick DS., Sheng M. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Bingol B., Tea JS., Phu L., Reichelt M., Bakalarski CE., Song Q., Foreman O., Kirkpatrick DS., Sheng M. DIP original experiment: DIP-260828X Nature 2014 IMEx The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature 2014 imex curation Bingol B., Tea JS., Phu L., Reichelt M., Bakalarski CE., Song Q., Foreman O., Kirkpatrick DS., Sheng M. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Bingol B., Tea JS., Phu L., Reichelt M., Bakalarski CE., Song Q., Foreman O., Kirkpatrick DS., Sheng M. DIP original experiment: DIP-260830X Nature 2014 IMEx The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. Nature 2014 imex curation Bingol B., Tea JS., Phu L., Reichelt M., Bakalarski CE., Song Q., Foreman O., Kirkpatrick DS., Sheng M. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Bingol B., Tea JS., Phu L., Reichelt M., Bakalarski CE., Song Q., Foreman O., Kirkpatrick DS., Sheng M. DIP original experiment: DIP-260831X Nature 2014 IMEx The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy. miro1_human Mitochondrial Rho GTPase 1 Ras homolog gene family member T1 Rac-GTP-binding protein-like protein RHOT1 ARHT1 protein protein human Homo sapiens Human MKKDVRILLVGEPRVGKTSLIMSLVSEEFPEEVPPRAEEITIPADVTPERVPTHIVDYSEAEQSDEQLHQEISQANVICIVYAVNNKHSIDKVTSRWIPLINERTDKDSRLPLILVGNKSDLVEYSSMETILPIMNQYTEIETCVECSAKNLKNISELFYYAQKAVLHPTGPLYCPEEKEMKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVKNVVRKHISDGVADSGLTLKGFLFLHTLFIQRGRHETTWTVLRRFGYDDDLDLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFKVFPYIPWGPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEYLGYLGYSILTEQESQASAVTVTRDKKIDLQKKQTQRNVFRCNVIGVKNCGKSGVLQALLGRNLMRQKKIREDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEAEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVKQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHVTQADLKSSTFWLRASFGATVFAVLGFAMYKALLKQR DIP protein Q8IXI2 original sequence version: 111 FE47AC3A4AF6F6C2 ubp30_human Ubiquitin carboxyl-terminal hydrolase 30 USP30 Ubiquitin-specific-processing protease 30 Deubiquitinating enzyme 30 Ubiquitin thioesterase 30 protein protein human Homo sapiens Human MLSSRAEAAMTAADRAIQRFLRTGAAVRYKVMKNWGVIGGIAAALAAGIYVIWGPITERKKRRKGLVPGLVNLGNTCFMNSLLQGLSACPAFIRWLEEFTSQYSRDQKEPPSHQYLSLTLLHLLKALSCQEVTDDEVLDASCLLDVLRMYRWQISSFEEQDAHELFHVITSSLEDERDRQPRVTHLFDVHSLEQQSEITPKQITCRTRGSPHPTSNHWKSQHPFHGRLTSNMVCKHCEHQSPVRFDTFDSLSLSIPAATWGHPLTLDHCLHHFISSESVRDVVCDNCTKIEAKGTLNGEKVEHQRTTFVKQLKLGKLPQCLCIHLQRLSWSSHGTPLKRHEHVQFNEFLMMDIYKYHLLGHKPSQHNPKLNKNPGPTLELQDGPGAPTPVLNQPGAPKTQIFMNGACSPSLLPTLSAPMPFPLPVVPDYSSSTYLFRLMAVVVHHGDMHSGHFVTYRRSPPSARNPLSTSNQWLWVSDDTVRKASLQEVLSSSAYLLFYERVLSRMQHQSQECKSEE DIP protein Q70CQ3 original sequence version: 97 DIP protein Q70CQ3 original sequence version: 104 68FA9B9BEBCFF8DF ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG tom20_human Mitochondrial import receptor subunit TOM20 homolog Outer mitochondrial membrane receptor Tom20 TOMM20 KIAA0016 Mitochondrial 20 kDa outer membrane protein protein protein human Homo sapiens Human MVGRNSAIAAGVCGALFIGYCIYFDRKRRSDPNFKNRLRERRKKQKLAKERAGLSKLPDLKDAEAVQKFFLEEIQLGEELLAQGEYEKGVDHLTNAIAVCGQPQQLLQVLQQTLPPPVFQMLLTKLPTISQRIVSAQSLAEDDVE DIP protein Q15388 original sequence version: 139 5153BD25AC5D9B3A ub-rhot1-1 2 5 unspecified role unspecified role prey prey human Homo sapiens Human 7 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal human Homo sapiens Human physical association physical association ub-tomm20-1 4 8 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range Q15388:p.[Lys56Arg;Lys61Arg;Lys68Arg] K56R/K61R/K68R mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R certain certain sequence position certain certain certain sequence position certain K R This feature has been corrected as a result of our quality control procedures. The original label was 'K56R/K61R/K68R'. Wed May 02 18:45:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys56arg,lys61arg,lys68arg' Tue Jun 30 17:18:18 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Lys56Arg;Lys61Arg;Lys68Arg]' human Homo sapiens Human 7 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal human Homo sapiens Human physical association physical association ub-tomm20-2 1 8 unspecified role unspecified role prey prey human Homo sapiens Human 7 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal human Homo sapiens Human physical association physical association ub-usp30-1 3 6 unspecified role unspecified role prey prey human Homo sapiens Human 7 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal human Homo sapiens Human physical association physical association