DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Pharmacological chaperones stabilize retromer to limit APP processing. Pharmacological chaperones stabilize retromer to limit APP processing. Nature chemical biology 2014 imex curation Mecozzi VJ., Berman DE., Simoes S., Vetanovetz C., Awal MR., Patel VM., Schneider RT., Petsko GA., Ringe D., Small SA. Only protein-protein interactions in vitro In vitro thermal shift thermal shift binding thermal shift predetermined predetermined participant predetermined Mecozzi VJ., Berman DE., Simoes S., Vetanovetz C., Awal MR., Patel VM., Schneider RT., Petsko GA., Ringe D., Small SA. DIP original experiment: DIP-260982X Nature chemical biology 2014 IMEx Pharmacological chaperones stabilize retromer to limit APP processing. Pharmacological chaperones stabilize retromer to limit APP processing. Pharmacological chaperones stabilize retromer to limit APP processing. Nature chemical biology 2014 imex curation Mecozzi VJ., Berman DE., Simoes S., Vetanovetz C., Awal MR., Patel VM., Schneider RT., Petsko GA., Ringe D., Small SA. Only protein-protein interactions in vitro In vitro thermal shift thermal shift binding thermal shift predetermined predetermined participant predetermined Mecozzi VJ., Berman DE., Simoes S., Vetanovetz C., Awal MR., Patel VM., Schneider RT., Petsko GA., Ringe D., Small SA. DIP original experiment: DIP-260981X Nature chemical biology 2014 IMEx Pharmacological chaperones stabilize retromer to limit APP processing. vp26a_human Vacuolar protein sorting-associated protein 26A VPS26A VPS26 Vesicle protein sorting 26A protein protein human Homo sapiens Human MSFLGGFFGPICEIDIVLNDGETRKMAEMKTEDGKVEKHYLFYDGESVSGKVNLAFKQPGKRLEHQGIRIEFVGQIELFNDKSNTHEFVNLVKELALPGELTQSRSYDFEFMQVEKPYESYIGANVRLRYFLKVTIVRRLTDLVKEYDLIVHQLATYPDVNNSIKMEVGIEDCLHIEFEYNKSKYHLKDVIVGKIYFLLVRIKIQHMELQLIKKEITGIGPSTTTETETIAKYEIMDGAPVKGESIPIRLFLAGYDPTPTMRDVNKKFSVRYFLNLVLVDEEDRRYFKQQEIILWRKAPEKLRKQRTNFHQRFESPESQASAEQPEM DIP protein O75436 original sequence version: 115 DIP protein O75436 original sequence version: 53 DIP protein O75436 original sequence version: 113 DIP protein O75436-1 original sequence version: 113 DIP protein O75436 original sequence version: 123 BD3B2EAA6CFCBFA9 vps35_human Vacuolar protein sorting-associated protein 35 Vesicle protein sorting 35 Maternal-embryonic 3 VPS35 MEM3 TCCCTA00141 protein protein human Homo sapiens Human MPTTQQSPQDEQEKLLDEAIQAVKVQSFQMKRCLDKNKLMDALKHASNMLGELRTSMLSPKSYYELYMAISDELHYLEVYLTDEFAKGRKVADLYELVQYAGNIIPRLYLLITVGVVYVKSFPQSRKDILKDLVEMCRGVQHPLRGLFLRNYLLQCTRNILPDEGEPTDEETTGDISDSMDFVLLNFAEMNKLWVRMQHQGHSRDREKRERERQELRILVGTNLVRLSQLEGVNVERYKQIVLTGILEQVVNCRDALAQEYLMECIIQVFPDEFHLQTLNPFLRACAELHQNVNVKNIIIALIDRLALFAHREDGPGIPADIKLFDIFSQQVATVIQSRQDMPSEDVVSLQVSLINLAMKCYPDRVDYVDKVLETTVEIFNKLNLEHIATSSAVSKELTRLLKIPVDTYNNILTVLKLKHFHPLFEYFDYESRKSMSCYVLSNVLDYNTEIVSQDQVDSIMNLVSTLIQDQPDQPVEDPDPEDFADEQSLVGRFIHLLRSEDPDQQYLILNTARKHFGAGGNQRIRFTLPPLVFAAYQLAFRYKENSKVDDKWEKKCQKIFSFAHQTISALIKAELAELPLRLFLQGALAAGEIGFENHETVAYEFMSQAFSLYEDEISDSKAQLAAITLIIGTFERMKCFSEENHEPLRTQCALAASKLLKKPDQGRAVSTCAHLFWSGRNTDKNGEELHGGKRVMECLKKALKIANQCMDPSLQVQLFIEILNRYIYFYEKENDAVTIQVLNQLIQKIREDLPNLESSEETEQINKHFHNTLEHLRLRRESPESEGPIYEGLIL DIP protein Q96QK1 original sequence version: 118 DIP protein Q96QK1 original sequence version: 44 DIP protein Q96QK1 original sequence version: 117 DIP protein Q96QK1 original sequence version: 127 28D2DD1C6B920A0A vps29_human Vacuolar protein sorting-associated protein 29 Vesicle protein sorting 29 PEP11 homolog VPS29 DC7 DC15 MDS007 protein protein human Homo sapiens Human MLVLVLGDLHIPHRCNSLPAKFKKLLVPGKIQHILCTGNLCTKESYDYLKTLAGDVHIVRGDFDENLNYPEQKVVTVGQFKIGLIHGHQVIPWGDMASLALLQRQFDVDILISGHTHKFEAFEHENKFYINPGSATGAYNALETNIIPSFVLMDIQASTVVTYVYQLIGDDVKVERIEYKKP DIP protein Q9UBQ0 original sequence version: 51 DIP protein Q9UBQ0-1 original sequence version: 117 DIP protein Q9UBQ0 original sequence version: 117 DIP protein Q9UBQ0 original sequence version: 129 6E0CDE6B720C9BF8 vps26a-vps35-5 2 3 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction vps29-vps35-12 1 5 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli 4 unspecified role unspecified role unspecified role unspecified role ecolx Escherichia coli direct interaction direct interaction