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          <fullName>Activating hotspot L205R mutation in PRKACA and adrenal Cushing's syndrome.</fullName>
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        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWESPAQNTAHLDQFERIKTLGTGSFGRVMLVKHKETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P17612 original sequence version: 171</attribute>
          <attribute name="remark-internal">DIP protein P17612 original sequence version: 175</attribute>
          <attribute name="remark-internal">DIP protein P17612 original sequence version: 178</attribute>
          <attribute name="remark-internal">DIP protein P17612-1 original sequence version: 177</attribute>
          <attribute name="remark-internal">DIP protein P17612 original sequence version: 186</attribute>
          <attribute name="remark-internal">DIP protein P17612 original sequence version: 102</attribute>
          <attribute name="remark-internal">DIP protein P17612-1 original sequence version: 102</attribute>
          <attribute name="crc64">BF6D3ECD2614E5AB</attribute>
        </attributeList>
      </interactor>
      <interactor id="3">
        <names>
          <shortLabel>kap0_human</shortLabel>
          <fullName>cAMP-dependent protein kinase type I-alpha regulatory subunit</fullName>
          <alias type="gene name synonym" typeAc="MI:0302">Tissue-specific extinguisher 1</alias>
          <alias type="gene name" typeAc="MI:0301">PRKAR1A</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PKR1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">PRKAR1</alias>
          <alias type="gene name synonym" typeAc="MI:0302">TSE1</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P10644" version="SP_93" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q567S7" version="SP_93" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="K7ER48" version="SP_169" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000351410" version="SP_238" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000376475" version="SP_238" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000445625" version="SP_238" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000464977" version="SP_238" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSP00000466459" version="SP_238" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-476431" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_002725.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_997636.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_997637.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011523285.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011523286.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="XP_011523287.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001263218.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001263219.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_001265362.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-34368N"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENSG00000108946" version="SP_238" refType="gene"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000358598" version="SP_238" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000392711" version="SP_238" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000536854" version="SP_238" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000586397" version="SP_238" refType="transcript"/>
          <secondaryRef db="ensembl" dbAc="MI:0476" id="ENST00000589228" version="SP_238" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0001707" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004862" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005737" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005771" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005813" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005829" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005952" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0006357" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0007143" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0008603" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0010738" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0016020" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0019904" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030552" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031588" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031594" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031625" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0032991" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0034236" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0035556" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0043949" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0044853" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045214" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0045835" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0046007" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0060038" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097224" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0097546" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0098978" version="SP_238"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:2000480" version="SP_238"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR000595" version="SP_238"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR003117" version="SP_238"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR012198" version="SP_238"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014710" version="SP_238"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018488" version="SP_238"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KJZ" version="SP_238"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-163615" version="SP_238"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-164378" version="SP_238"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-180024" version="SP_238"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-381676" version="SP_238"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-432040" version="SP_238"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-442720" version="SP_238"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-5610787" version="SP_238"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9660821" version="SP_238"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-9664323" version="SP_238"/>
          <secondaryRef db="reactome" dbAc="MI:0467" id="R-HSA-983231" version="SP_238"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR018490" version="SP_238"/>
          <secondaryRef db="mint" dbAc="MI:0471" id="P10644" version="SP_238"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KJX" version="SP_238"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5KJY" version="SP_238"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="9606">
          <names>
            <shortLabel>human</shortLabel>
            <fullName>Homo sapiens</fullName>
            <alias type="synonym" typeAc="MI:1041">Human</alias>
          </names>
        </organism>
        <sequence>MESGSTAASEEARSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFERLEKEEAKQIQNLQKAGTRTDSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFSVSFIAGETVIQQGDEGDNFYVIDQGETDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P10644 original sequence version: 173</attribute>
          <attribute name="remark-internal">DIP protein P10644 original sequence version: 127</attribute>
          <attribute name="remark-internal">DIP protein P10644 original sequence version: 134</attribute>
          <attribute name="remark-internal">DIP protein P10644 original sequence version: 179</attribute>
          <attribute name="crc64">2D04F08CE8857A6D</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="4" imexId="IM-24260-1">
        <names>
          <shortLabel>prkar1a-prkaca-3</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-63041E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16099148" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-24260-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="5">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>prey</shortLabel>
                  <fullName>prey</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0498" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-58" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human</shortLabel>
                  <fullName>Homo sapiens</fullName>
                  <alias type="synonym" typeAc="MI:1041">Human</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
          <participant id="6">
            <interactorRef>3</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>bait</shortLabel>
                  <fullName>bait</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0496" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-49" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <featureList>
              <feature id="7">
                <names>
                  <shortLabel>Flag-tag</shortLabel>
                  <fullName>Flag-tag</fullName>
                </names>
                <xref>
                  <primaryRef db="intact" dbAc="MI:0469" id="EBI-16099153" refType="identity" refTypeAc="MI:0356"/>
                </xref>
                <featureType>
                  <names>
                    <shortLabel>flag tag</shortLabel>
                    <fullName>flag tag</fullName>
                    <alias type="go synonym" typeAc="MI:0303">FLAG-tagged</alias>
                    <alias type="go synonym" typeAc="MI:0303">FLAG</alias>
                    <alias type="go synonym" typeAc="MI:0303">DYKDDDDKV epitope tag</alias>
                    <alias type="synonym" typeAc="MI:1041">DYKDDDDKV epitope tag</alias>
                    <alias type="synonym" typeAc="MI:1041">FLAG</alias>
                    <alias type="synonym" typeAc="MI:1041">FLAG-tagged</alias>
                  </names>
                  <xref>
                    <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0518" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="intact" dbAc="MI:0469" id="EBI-456503" refType="identity" refTypeAc="MI:0356"/>
                    <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                  </xref>
                </featureType>
                <featureRangeList>
                  <featureRange>
                    <startStatus>
                      <names>
                        <shortLabel>n-term range</shortLabel>
                        <fullName>n-terminal range</fullName>
                        <alias type="synonym" typeAc="MI:1041">n-term range</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </startStatus>
                    <endStatus>
                      <names>
                        <shortLabel>n-term range</shortLabel>
                        <fullName>n-terminal range</fullName>
                        <alias type="synonym" typeAc="MI:1041">n-term range</alias>
                      </names>
                      <xref>
                        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:1040" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-2929795" refType="identity" refTypeAc="MI:0356"/>
                        <secondaryRef db="pubmed" dbAc="MI:0446" id="14760721" refType="primary-reference" refTypeAc="MI:0358"/>
                      </xref>
                    </endStatus>
                  </featureRange>
                </featureRangeList>
              </feature>
            </featureList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="9606">
                <names>
                  <shortLabel>human</shortLabel>
                  <fullName>Homo sapiens</fullName>
                  <alias type="synonym" typeAc="MI:1041">Human</alias>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>physical association</shortLabel>
            <fullName>physical association</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0915" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1813147" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>