DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature 2014 imex curation Chen X., Iliopoulos D., Zhang Q., Tang Q., Greenblatt MB., Hatziapostolou M., Lim E., Tam WL., Ni M., Chen Y., Mai J., Shen H., Hu DZ., Adoro S., Hu B., Song M., Tan C., Landis MD., Ferrari M., Shin SJ., Brown M., Chang JC., Liu XS., Glimcher LH. Only protein-protein interactions in vitro In vitro pull down pull down predetermined predetermined participant predetermined Chen X., Iliopoulos D., Zhang Q., Tang Q., Greenblatt MB., Hatziapostolou M., Lim E., Tam WL., Ni M., Chen Y., Mai J., Shen H., Hu DZ., Adoro S., Hu B., Song M., Tan C., Landis MD., Ferrari M., Shin SJ., Brown M., Chang JC., Liu XS., Glimcher LH. DIP original experiment: DIP-259864X Nature 2014 IMEx XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature 2014 imex curation Chen X., Iliopoulos D., Zhang Q., Tang Q., Greenblatt MB., Hatziapostolou M., Lim E., Tam WL., Ni M., Chen Y., Mai J., Shen H., Hu DZ., Adoro S., Hu B., Song M., Tan C., Landis MD., Ferrari M., Shin SJ., Brown M., Chang JC., Liu XS., Glimcher LH. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Chen X., Iliopoulos D., Zhang Q., Tang Q., Greenblatt MB., Hatziapostolou M., Lim E., Tam WL., Ni M., Chen Y., Mai J., Shen H., Hu DZ., Adoro S., Hu B., Song M., Tan C., Landis MD., Ferrari M., Shin SJ., Brown M., Chang JC., Liu XS., Glimcher LH. DIP original experiment: DIP-259862X Nature 2014 IMEx XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. Nature 2014 imex curation Chen X., Iliopoulos D., Zhang Q., Tang Q., Greenblatt MB., Hatziapostolou M., Lim E., Tam WL., Ni M., Chen Y., Mai J., Shen H., Hu DZ., Adoro S., Hu B., Song M., Tan C., Landis MD., Ferrari M., Shin SJ., Brown M., Chang JC., Liu XS., Glimcher LH. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Chen X., Iliopoulos D., Zhang Q., Tang Q., Greenblatt MB., Hatziapostolou M., Lim E., Tam WL., Ni M., Chen Y., Mai J., Shen H., Hu DZ., Adoro S., Hu B., Song M., Tan C., Landis MD., Ferrari M., Shin SJ., Brown M., Chang JC., Liu XS., Glimcher LH. DIP original experiment: DIP-259863X Nature 2014 IMEx XBP1 promotes triple-negative breast cancer by controlling the HIF1α pathway. xbp1_human X-box-binding protein 1 XBP1 TREB5 XBP2 Tax-responsive element-binding protein 5 protein protein human Homo sapiens Human MVVVAAAPNPADGTPKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGLPQARKRQRLTHLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQKLLLENQLLREKTHGLVVENQELRQRLGMDALVAEEEAEAKGNEVRPVAGSAESAALRLRAPLQQVQAQLSPLQNISPWILAVLTLQIQSLISCWAFWTTWTQSCSSNALPQSLPAWRSSQRSTQKDPVPYQPPFLCQWGRHQPSWKPLMN DIP protein P17861 original sequence version: 143 Transcription factor essential for hepatocyte growth, the differentiation of plasma cells, the immunoglobulin secretion, and the unfolded protein response (UPR). Acts during endoplasmic reticulum stress (ER) by activating unfolded protein response (UPR) target genes via direct binding to the UPR element (UPRE). Binds DNA preferably to the CRE-like element 5'-GATGACGTG[TG]N(3)[AT]T-3', and also to some TPA response elements (TRE). Binds to the HLA DR-alpha promoter. Binds to the Tax-responsive element (TRE) of HTLV-I mint A4EF69EEE0D344A6 hif1a_human Hypoxia-inducible factor 1-alpha ARNT-interacting protein Member of PAS protein 1 Basic-helix-loop-helix-PAS protein MOP1 HIF1A MOP1 BHLHE78 PASD8 PAS domain-containing protein 8 Class E basic helix-loop-helix protein 78 protein protein human Homo sapiens Human MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRTTVPEEELNPKILALQNAQRKRKMEHDGSLFQAVGIGTLLQQPDDHAATTSLSWKRVKGCKSSEQNGMEQKTIILIPSDLACRLLGQSMDESGLPQLTSYDCEVNAPIQGSRNLLQGEELLRALDQVN DIP protein Q16665 original sequence version: 94 DIP protein Q16665 original sequence version: 98 DIP protein Q16665-1 original sequence version: 102 DIP protein Q16665 original sequence version: 102 DIP protein Q16665 original sequence version: 127 DIP protein Q16665 original sequence version: 120 DIP protein Q16665 original sequence version: 169 DIP protein Q16665 original sequence version: 174 DIP protein Q16665-1 original sequence version: 174 DIP protein Q16665-1 original sequence version: 191 DIP protein Q16665 original sequence version: 191 DIP protein Q16665 original sequence version: 179 DIP protein Q16665 original sequence version: 150 DIP protein Q16665 original sequence version: 156 DIP protein Q16665 original sequence version: 177 ABD4F7DAA135BE2D hif1a-xbp1-1 2 4 unspecified role unspecified role prey prey human Homo sapiens Human 5 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association hif1a-xbp1-2 3 4 unspecified role unspecified role prey prey human Homo sapiens Human 5 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association xbp1-hif1a-1 1 4 unspecified role unspecified role bait bait Region 1-133 Region 1-133 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli 5 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association