<?xml version='1.0' encoding='UTF-8'?>
<entrySet xmlns="http://psi.hupo.org/mi/mif300" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://psi.hupo.org/mi/mif300 https://raw.githubusercontent.com/HUPO-PSI/miXML/master/3.0/src/MIF300.xsd" level="3" version="0" minorVersion="0">
  <entry>
    <source releaseDate="2022-02-03">
      <names>
        <shortLabel>DIP</shortLabel>
        <fullName>Database of Interacting Proteins</fullName>
      </names>
      <xref>
        <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="pubmed" dbAc="MI:0446" id="14681454" refType="identity" refTypeAc="MI:0356"/>
        <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1579232" refType="identity" refTypeAc="MI:0356"/>
      </xref>
      <attributeList>
        <attribute name="postaladdress">611 Young Drive East; Los Angeles CA 90095; USA</attribute>
        <attribute name="url" nameAc="MI:0614">http://dip.doe-mbi.ucla.edu/</attribute>
        <attribute name="contact-email" nameAc="MI:0634">dip@mbi.ucla.edu</attribute>
      </attributeList>
    </source>
    <experimentList>
      <experimentDescription id="1">
        <names>
          <fullName>Molecular mechanism of antibody-mediated activation of β-galactosidase.</fullName>
        </names>
        <bibref>
          <xref>
            <primaryRef db="pubmed" dbAc="MI:0446" id="24613486" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="doi" dbAc="MI:0574" id="10.1016/j.str.2014.01.011" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16095849" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="imex" dbAc="MI:0670" id="IM-22663" refType="imex-primary" refTypeAc="MI:0662"/>
          </xref>
          <attributeList>
            <attribute name="publication title" nameAc="MI:1091">Molecular mechanism of antibody-mediated activation of β-galactosidase.</attribute>
            <attribute name="journal" nameAc="MI:0885">Structure (London, England : 1993)</attribute>
            <attribute name="publication year" nameAc="MI:0886">2014</attribute>
            <attribute name="curation depth" nameAc="MI:0955">imex curation</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
            <attribute name="author-list" nameAc="MI:0636">Vinothkumar KR.,  McMullan G.,  Henderson R.</attribute>
            <attribute name="full coverage" nameAc="MI:0957">Only protein-protein interactions</attribute>
            <attribute name="imex curation" nameAc="MI:0959"/>
          </attributeList>
        </bibref>
        <xref>
          <primaryRef db="imex" dbAc="MI:0670" id="IM-22663" refType="imex-primary" refTypeAc="MI:0662"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-260609X" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="wwpdb" dbAc="MI:0805" id="4CKD" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="pubmed" dbAc="MI:0446" id="24613486" refType="primary-reference" refTypeAc="MI:0358"/>
          <secondaryRef db="doi" dbAc="MI:0574" id="10.1016/j.str.2014.01.011" refType="primary-reference" refTypeAc="MI:0358"/>
        </xref>
        <hostOrganismList>
          <hostOrganism ncbiTaxId="562">
            <names>
              <shortLabel>ecolx</shortLabel>
              <fullName>Escherichia coli</fullName>
            </names>
          </hostOrganism>
        </hostOrganismList>
        <interactionDetectionMethod>
          <names>
            <shortLabel>3d-em</shortLabel>
            <fullName>3D electron microscopy</fullName>
            <alias type="synonym" typeAc="MI:1041">3D-EM</alias>
            <alias type="synonym" typeAc="MI:1041">electron tomog</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0410" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608522" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="12160704" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionDetectionMethod>
        <participantIdentificationMethod>
          <names>
            <shortLabel>predetermined</shortLabel>
            <fullName>predetermined participant</fullName>
            <alias type="synonym" typeAc="MI:1041">predetermined</alias>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0396" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1465" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </participantIdentificationMethod>
        <attributeList>
          <attribute name="author-list" nameAc="MI:0636">Vinothkumar KR., McMullan G., Henderson R.</attribute>
          <attribute name="comment" nameAc="MI:0612">DIP original experiment: DIP-260609X</attribute>
          <attribute name="journal" nameAc="MI:0885">Structure (London, England : 1993)</attribute>
          <attribute name="publication year" nameAc="MI:0886">2014</attribute>
          <attribute name="curation depth" nameAc="MI:0955">IMEx</attribute>
          <attribute name="title" nameAc="MI:1091">Molecular mechanism of antibody-mediated activation of β-galactosidase.</attribute>
        </attributeList>
      </experimentDescription>
    </experimentList>
    <interactorList>
      <interactor id="2">
        <names>
          <shortLabel>bgal_ecoli</shortLabel>
          <fullName>Beta-galactosidase</fullName>
          <alias type="gene name" typeAc="MI:0301">lacZ</alias>
          <alias type="locus name" typeAc="MI:0305">b0344</alias>
          <alias type="locus name" typeAc="MI:0305">JW0335</alias>
          <alias type="gene name synonym" typeAc="MI:0302">Lactase</alias>
        </names>
        <xref>
          <primaryRef db="uniprotkb" dbAc="MI:0486" id="P00722" version="SP_87" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="uniprotkb" dbAc="MI:0486" id="Q2MC80" version="SP_87" refType="secondary-ac" refTypeAc="MI:0360"/>
          <secondaryRef db="ensemblbacteria" id="AAC73447" version="SP_209" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblbacteria" id="BAE76126" version="SP_209" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-369998" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="ensemblbacteria" id="AAC73447" version="SP_209" refType="transcript"/>
          <secondaryRef db="ensemblbacteria" id="b0344" version="SP_209" refType="gene"/>
          <secondaryRef db="ensemblbacteria" id="BAE76126" version="SP_209" refType="gene"/>
          <secondaryRef db="ensemblbacteria" id="BAE76126" version="SP_209" refType="transcript"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0000287" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0004565" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0005990" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0009341" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0030246" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0031420" version="SP_209"/>
          <secondaryRef db="go" dbAc="MI:0448" id="GO:0042802" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR004199" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006101" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006102" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006103" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR006104" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR008979" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR011013" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR013783" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR014718" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR017853" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023230" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023232" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR023933" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR032312" version="SP_209"/>
          <secondaryRef db="interpro" dbAc="MI:0449" id="IPR036156" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1DP0" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1F4A" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1F4H" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1HN1" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1JYN" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1JYV" version="SP_209"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="1JZ2" version="SP_209"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3CZJ" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3DYM" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3DYO" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3DYP" version="SP_209"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3I3D" version="SP_209"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6DRV" version="SP_209"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MUZ" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MV0" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3MV1" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3SEP" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3T08" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3T09" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3T0A" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3T0B" version="SP_209"/>
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          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3T2Q" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VD3" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VD4" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VD5" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VD7" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VD9" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VDA" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VDB" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="3VDC" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4CKD" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4DUV" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4DUW" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4DUX" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4TTG" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4V40" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4V41" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4V44" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="4V45" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="5A1A" version="SP_209"/>
          <secondaryRef db="rcsb pdb" dbAc="MI:0460" id="6CVM" version="SP_209"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="WP_000177906.1"/>
          <secondaryRef db="refseq" dbAc="MI:0481" id="NP_414878.1"/>
          <secondaryRef db="dip" dbAc="MI:0465" id="DIP-10081N"/>
        </xref>
        <interactorType>
          <names>
            <shortLabel>protein</shortLabel>
            <fullName>protein</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0326" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-619654" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
            <secondaryRef db="so" dbAc="MI:0601" id="SO:0000358" refType="see-also" refTypeAc="MI:0361"/>
          </xref>
        </interactorType>
        <organism ncbiTaxId="83333">
          <names>
            <shortLabel>ecoli</shortLabel>
            <fullName>Escherichia coli (strain K12)</fullName>
          </names>
        </organism>
        <sequence>MTMITDSLAVVLQRRDWENPGVTQLNRLAAHPPFASWRNSEEARTDRPSQQLRSLNGEWRFAWFPAPEAVPESWLECDLPEADTVVVPSNWQMHGYDAPIYTNVTYPITVNPPFVPTENPTGCYSLTFNVDESWLQEGQTRIIFDGVNSAFHLWCNGRWVGYGQDSRLPSEFDLSAFLRAGENRLAVMVLRWSDGSYLEDQDMWRMSGIFRDVSLLHKPTTQISDFHVATRFNDDFSRAVLEAEVQMCGELRDYLRVTVSLWQGETQVASGTAPFGGEIIDERGGYADRVTLRLNVENPKLWSAEIPNLYRAVVELHTADGTLIEAEACDVGFREVRIENGLLLLNGKPLLIRGVNRHEHHPLHGQVMDEQTMVQDILLMKQNNFNAVRCSHYPNHPLWYTLCDRYGLYVVDEANIETHGMVPMNRLTDDPRWLPAMSERVTRMVQRDRNHPSVIIWSLGNESGHGANHDALYRWIKSVDPSRPVQYEGGGADTTATDIICPMYARVDEDQPFPAVPKWSIKKWLSLPGETRPLILCEYAHAMGNSLGGFAKYWQAFRQYPRLQGGFVWDWVDQSLIKYDENGNPWSAYGGDFGDTPNDRQFCMNGLVFADRTPHPALTEAKHQQQFFQFRLSGQTIEVTSEYLFRHSDNELLHWMVALDGKPLASGEVPLDVAPQGKQLIELPELPQPESAGQLWLTVRVVQPNATAWSEAGHISAWQQWRLAENLSVTLPAASHAIPHLTTSEMDFCIELGNKRWQFNRQSGFLSQMWIGDKKQLLTPLRDQFTRAPLDNDIGVSEATRIDPNAWVERWKAAGHYQAEAALLQCTADTLADAVLITTAHAWQHQGKTLFISRKTYRIDGSGQMAITVDVEVASDTPHPARIGLNCQLAQVAERVNWLGLGPQENYPDRLTAACFDRWDLPLSDMYTPYVFPSENGLRCGTRELNYGPHQWRGDFQFNISRYSQQQLMETSHRHLLHAEEGTWLNIDGFHMGIGGDDSWSPSVSAEFQLSAGRYHYQLVWCQK</sequence>
        <attributeList>
          <attribute name="remark-internal">DIP protein P00722 original sequence version: 148</attribute>
          <attribute name="remark-internal">DIP protein P00722 original sequence version: 154</attribute>
          <attribute name="remark-internal">DIP protein P00722 original sequence version: 167</attribute>
          <attribute name="crc64">9D295EF4CEF90B08</attribute>
        </attributeList>
      </interactor>
    </interactorList>
    <interactionList>
      <interaction id="3" imexId="IM-22663-1">
        <names>
          <shortLabel>lacz-2</shortLabel>
        </names>
        <xref>
          <primaryRef db="dip" dbAc="MI:0465" id="DIP-191946E" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="intact" dbAc="MI:0469" id="EBI-16095869" refType="identity" refTypeAc="MI:0356"/>
          <secondaryRef db="psi-mi" dbAc="MI:0488" id="MI:0465" refType="imex source"/>
          <secondaryRef db="imex" dbAc="MI:0670" id="IM-22663-1" refType="imex-primary" refTypeAc="MI:0662"/>
        </xref>
        <experimentList>
          <experimentRef>1</experimentRef>
        </experimentList>
        <participantList>
          <participant id="4">
            <interactorRef>2</interactorRef>
            <biologicalRole>
              <names>
                <shortLabel>unspecified role</shortLabel>
                <fullName>unspecified role</fullName>
              </names>
              <xref>
                <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="intact" dbAc="MI:0469" id="EBI-77781" refType="identity" refTypeAc="MI:0356"/>
                <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
              </xref>
            </biologicalRole>
            <experimentalRoleList>
              <experimentalRole>
                <names>
                  <shortLabel>unspecified role</shortLabel>
                  <fullName>unspecified role</fullName>
                </names>
                <xref>
                  <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0499" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="intact" dbAc="MI:0469" id="EBI-1383079" refType="identity" refTypeAc="MI:0356"/>
                  <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
                </xref>
              </experimentalRole>
            </experimentalRoleList>
            <hostOrganismList>
              <hostOrganism ncbiTaxId="562">
                <names>
                  <shortLabel>ecolx</shortLabel>
                  <fullName>Escherichia coli</fullName>
                </names>
              </hostOrganism>
            </hostOrganismList>
          </participant>
        </participantList>
        <interactionType>
          <names>
            <shortLabel>direct interaction</shortLabel>
            <fullName>direct interaction</fullName>
          </names>
          <xref>
            <primaryRef db="psi-mi" dbAc="MI:0488" id="MI:0407" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="intact" dbAc="MI:0469" id="EBI-608833" refType="identity" refTypeAc="MI:0356"/>
            <secondaryRef db="pubmed" dbAc="MI:0446" id="14755292" refType="primary-reference" refTypeAc="MI:0358"/>
          </xref>
        </interactionType>
      </interaction>
    </interactionList>
  </entry>
</entrySet>