DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nature cell biology 2014 imex curation Wang Y., Li Y., Toth JI., Petroski MD., Zhang Z., Zhao JC. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang Y., Li Y., Toth JI., Petroski MD., Zhang Z., Zhao JC. DIP original experiment: DIP-260092X Nature cell biology 2014 IMEx N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nature cell biology 2014 imex curation Wang Y., Li Y., Toth JI., Petroski MD., Zhang Z., Zhao JC. Only protein-protein interactions mouse Mus musculus Mouse anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Wang Y., Li Y., Toth JI., Petroski MD., Zhang Z., Zhao JC. DIP original experiment: DIP-260093X Nature cell biology 2014 IMEx N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. Nature cell biology 2014 imex curation Wang Y., Li Y., Toth JI., Petroski MD., Zhang Z., Zhao JC. Only protein-protein interactions spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm pull down pull down weight by comassie molecular weight estimation by coomasie staining weight by comassie Wang Y., Li Y., Toth JI., Petroski MD., Zhang Z., Zhao JC. DIP original experiment: DIP-260094X Nature cell biology 2014 IMEx N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cells. met14_mouse N6-adenosine-methyltransferase non-catalytic subunit Mettl14 Kiaa1627 Methyltransferase-like protein 14 protein protein mouse Mus musculus Mouse MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNSKRKCLDEGETDEDKVEEYKDELEMQQEEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGTHRGGFTPR DIP protein Q3UIK4 original sequence version: 59 mta70_mouse N6-adenosine-methyltransferase subunit METTL3 Mettl3 Mta70 Methyltransferase-like protein 3 N6-adenosine-methyltransferase 70 kDa subunit protein protein mouse Mus musculus Mouse MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSSGPKPSTTSVAPELATDPELEKKLLHHLSDLALTLPTDAVSIRLAISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVADKKGLGEVAGTIAGQKRRAEQDLTTVTTFASSLASGLASSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACVDSESPGSKEHMPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL DIP protein Q8C3P7 original sequence version: 88 mint N6-methyltransferase that methylates adenosine residues of some mRNAs. N6-methyladenosine (m6A), which is present at internal sites of some mRNAs, may play a role in the efficiency of mRNA splicing, transport or translation 0DBDA2392A37A018 mta70_human N6-adenosine-methyltransferase catalytic subunit N6-adenosine-methyltransferase 70 kDa subunit METTL3 MTA70 Methyltransferase-like protein 3 protein protein human Homo sapiens Human MSDTWSSIQAHKKQLDSLRERLQRRRKQDSGHLDLRNPEAALSPTFRSDSPVPTAPTSGGPKPSTASAVPELATDPELEKKLLHHLSDLALTLPTDAVSICLAISTPDAPATQDGVESLLQKFAAQELIEVKRGLLQDDAHPTLVTYADHSKLSAMMGAVAEKKGPGEVAGTVTGQKRRAEQDSTTVAAFASSLVSGLNSSASEPAKEPAKKSRKHAASDVDLEIESLLNQQSTKEQQSKKVSQEILELLNTTTAKEQSIVEKFRSRGRAQVQEFCDYGTKEECMKASDADRPCRKLHFRRIINKHTDESLGDCSFLNTCFHMDTCKYVHYEIDACMDSEAPGSKDHTPSQELALTQSVGGDSSADRLFPPQWICCDIRYLDVSILGKFAVVMADPPWDIHMELPYGTLTDDEMRRLNIPVLQDDGFLFLWVTGRAMELGRECLNLWGYERVDEIIWVKTNQLQRIIRTGRTGHWLNHGKEHCLVGVKGNPQGFNQGLDCDVIVAEVRSTSHKPDEIYGMIERLSPGTRKIELFGRPHNVQPNWITLGNQLDGIHLLDPDVVARFKQRYPDGIISKPKNL DIP protein Q86U44 original sequence version: 95 DIP protein Q86U44 original sequence version: 96 63A7F10195A3C6AC met14_human N6-adenosine-methyltransferase non-catalytic subunit Methyltransferase-like protein 14 METTL14 KIAA1627 protein protein human Homo sapiens Human MDSRLQEIRERQKLRRQLLAQQLGAESADSIGAVLNSKDEQREIAETRETCRASYDTSAPNAKRKYLDEGETDEDKMEEYKDELEMQQDEENLPYEEEIYKDSSTFLKGTQSLNPHNDYCQHFVDTGHRPQNFIRDVGLADRFEEYPKLRELIRLKDELIAKSNTPPMYLQADIEAFDIRELTPKFDVILLEPPLEEYYRETGITANEKCWTWDDIMKLEIDEIAAPRSFIFLWCGSGEGLDLGRVCLRKWGYRRCEDICWIKTNKNNPGKTKTLDPKAVFQRTKEHCLMGIKGTVKRSTDGDFIHANVDIDLIITEEPEIGNIEKPVEIFHIIEHFCLGRRRLHLFGRDSTIRPGWLTVGPTLTNSNYNAETYASYFSAPNSYLTGCTEEIERLRPKSPPPKSKSDRGGGAPRGGGRGGTSAGRGRERNRSNFRGERGGFRGGRGGAHRGGFPPR DIP protein Q9HCE5 original sequence version: 72 DIP protein Q9HCE5 original sequence version: 73 DIP protein Q9HCE5 original sequence version: 95 73A45B66BB76E241 mettl3-mettl14-3 1 5 unspecified role unspecified role bait bait mouse Mus musculus Mouse 4 unspecified role unspecified role prey prey mouse Mus musculus Mouse physical association physical association mettl14-mettl3-9 2 5 unspecified role unspecified role prey prey mouse Mus musculus Mouse 4 unspecified role unspecified role bait bait mouse Mus musculus Mouse physical association physical association mettl14-mettl3-10 3 6 unspecified role unspecified role prey prey Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 7 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction