DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structural mechanism of ligand activation in human GABA(B) receptor. Structural mechanism of ligand activation in human GABA(B) receptor. Nature 2013 imex curation Geng Y., Bush M., Mosyak L., Wang F., Fan QR. Only protein-protein interactions human Homo sapiens Human crosslink cross-linking study crosslink anti tag western anti tag western blot anti tag western Geng Y., Bush M., Mosyak L., Wang F., Fan QR. DIP original experiment: DIP-256013X Nature 2013 IMEx Structural mechanism of ligand activation in human GABA(B) receptor. Structural mechanism of ligand activation in human GABA(B) receptor. Structural mechanism of ligand activation in human GABA(B) receptor. Nature 2013 imex curation Geng Y., Bush M., Mosyak L., Wang F., Fan QR. Only protein-protein interactions spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm molecular sieving molecular sieving Gel Filtration Size Exclusion Chromatography Size Exclusion Chromatography Gel Filtration Sizing column predetermined predetermined participant predetermined Geng Y., Bush M., Mosyak L., Wang F., Fan QR. DIP original experiment: DIP-256011X Nature 2013 IMEx Structural mechanism of ligand activation in human GABA(B) receptor. Structural mechanism of ligand activation in human GABA(B) receptor. Structural mechanism of ligand activation in human GABA(B) receptor. Nature 2013 imex curation Geng Y., Bush M., Mosyak L., Wang F., Fan QR. Only protein-protein interactions spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Geng Y., Bush M., Mosyak L., Wang F., Fan QR. DIP original experiment: DIP-256012X Nature 2013 IMEx Structural mechanism of ligand activation in human GABA(B) receptor. gabr2_human Gamma-aminobutyric acid type B receptor subunit 2 G-protein coupled receptor 51 HG20 GABBR2 GPR51 GPRC3B protein protein human Homo sapiens Human MASPRSSGQPGPPPPPPPPPARLLLLLLLPLLLPLAPGAWGWARGAPRPPPSSPPLSIMGLMPLTKEVAKGSIGRGVLPAVELAIEQIRNESLLRPYFLDLRLYDTECDNAKGLKAFYDAIKYGPNHLMVFGGVCPSVTSIIAESLQGWNLVQLSFAATTPVLADKKKYPYFFRTVPSDNAVNPAILKLLKHYQWKRVGTLTQDVQRFSEVRNDLTGVLYGEDIEISDTESFSNDPCTSVKKLKGNDVRIILGQFDQNMAAKVFCCAYEENMYGSKYQWIIPGWYEPSWWEQVHTEANSSRCLRKNLLAAMEGYIGVDFEPLSSKQIKTISGKTPQQYEREYNNKRSGVGPSKFHGYAYDGIWVIAKTLQRAMETLHASSRHQRIQDFNYTDHTLGRIILNAMNETNFFGVTGQVVFRNGERMGTIKFTQFQDSREVKVGEYNAVADTLEIINDTIRFQGSEPPKDKTIILEQLRKISLPLYSILSALTILGMIMASAFLFFNIKNRNQKLIKMSSPYMNNLIILGGMLSYASIFLFGLDGSFVSEKTFETLCTVRTWILTVGYTTAFGAMFAKTWRVHAIFKNVKMKKKIIKDQKLLVIVGGMLLIDLCILICWQAVDPLRRTVEKYSMEPDPAGRDISIRPLLEHCENTHMTIWLGIVYAYKGLLMLFGCFLAWETRNVSIPALNDSKYIGMSVYNVGIMCIIGAAVSFLTRDQPNVQFCIVALVIIFCSTITLCLVFVPKLITLRTNPDAATQNRRFQFTQNQKKEDSKTSTSVTSVNQASTSRLEGLQSENHRLRMKITELDKDLEEVTMQLQDTPEKTTYIKQNHYQELNDILNLGNFTESTDGGKAILKNHLDQNPQLQWNTTEPSRTCKDPIEDINSPEHIQRRLSLQLPILHHAYLPSIGGVDASCVSPCVSPTASPRHRHVPPSFRVMVSGL DIP protein O75899 original sequence version: 136 09F1773DB0673C5D q9ubs5-2 Gamma-aminobutyric acid type B receptor subunit 1 GABBR1 GPRC3A protein protein human Homo sapiens Human MGPGAPFARVGWPLPLLVVMAAGVAPVWASHSPHLPRPHSRVPPHPSSERRAVYIGALFPMSGGWPGGQACQPAVEMALEDVNSRRDILPDYELKLIHHDSKCDPGQATKYLYELLYNDPIKIILMPGCSSVSTLVAEAARMWNLIVLSYGSSSPALSNRQRFPTFFRTHPSATLHNPTRVKLFEKWGWKKIATIQQTTEVFTSTLDDLEERVKEAGIEITFRQSFFSDPAVPVKNLKRQDARIIVGLFYETEARKVFCEVYKERLFGKKYVWFLIGWYADNWFKIYDPSINCTVDEMTEAVEGHITTEIVMLNPANTRSISNMTSQEFVEKLTKRLKRHPEETGGFQEAPLAYDAIWALALALNKTSGGGGRSGVRLEDFNYNNQTITDQIYRAMNSSSFEGVSGHVVFDASGSRMAWTLIEQLQGGSYKKIGYYDSTKDDLSWSKTDKWIGGSPPADQTLVIKTFRFLSQKLFISVSVLSSLGIVLAVVCLSFNIYNSHVRYIQNSQPNLNNLTAVGCSLALAAVFPLGLDGYHIGRNQFPFVCQARLWLLGLGFSLGYGSMFTKIWWVHTVFTKKEEKKEWRKTLEPWKLYATVGLLVGMDVLTLAIWQIVDPLHRTIETFAKEEPKEDIDVSILPQLEHCSSRKMNTWLGIFYGYKGLLLLLGIFLAYETKSVSTEKINDHRAVGMAIYNVAVLCLITAPVTMILSSQQDAAFAFASLAIVFSSYITLVVLFVPKMRRLITRGEWQSEAQDTMKTGSSTNNNEEEKSRLLEKENRELEKIIAEKEERVSELRHQLQSRQQLRSRRHPPTPPEPSGGLPRGPPEPPDRLSCDGSRVHLLYK DIP protein Q9UBS5-2 original sequence version: 140 gabbr1-gabbr2-7 1 4 unspecified role unspecified role unspecified role unspecified role O75899:p.Gln206Cys Q206C mutation mutation certain certain sequence position certain certain certain sequence position certain Q C This feature has been corrected as a result of our quality control procedures. The original label was 'Q206C'. Wed May 02 20:18:03 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'gln206cys' Tue Jun 30 18:51:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Gln206Cys' HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human 5 unspecified role unspecified role unspecified role unspecified role Q9UBS5-2:p.Thr198Cys T198C mutation mutation certain certain sequence position certain certain certain sequence position certain T C This feature has been corrected as a result of our quality control procedures. The original label was 'T198C'. Wed May 02 18:18:59 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'thr198cys' Tue Jun 30 17:50:06 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Thr198Cys' Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined human Homo sapiens Human direct interaction direct interaction gabbr1-gabbr2-8 2 4 unspecified role unspecified role unspecified role unspecified role Region 1-466 Region 1-466 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 5 unspecified role unspecified role unspecified role unspecified role Region 48-459 Region 48-459 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction gabbr1-gabbr2-9 3 4 unspecified role unspecified role unspecified role unspecified role Region 1-466 Region 1-466 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm 5 unspecified role unspecified role unspecified role unspecified role Region 48-459 Region 48-459 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain spofr Spodoptera frugiperda (Fall armyworm) Fall armyworm direct interaction direct interaction