DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions in vitro In vitro anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254680X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254685X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254681X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254678X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions in vitro In vitro pull down pull down anti tag western anti tag western blot anti tag western Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254674X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254682X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip anti tag western anti tag western blot anti tag western Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254679X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254676X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254673X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions in vitro In vitro pull down pull down western blot western blot Immuno blot Immuno blot Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254675X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions human Homo sapiens Human anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254677X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions in vitro In vitro anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254684X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. PLoS biology 2012 imex curation Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Yao P., Potdar AA., Ray PS., Eswarappa SM., Flagg AC., Willard B., Fox PL. DIP original experiment: DIP-254683X PLoS biology 2012 IMEx The HILDA complex coordinates a conditional switch in the 3'-untranslated region of the VEGFA mRNA. roa2_human Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B1 HNRPA2B1 protein protein human Homo sapiens Human MEKTLETVPLERKKREKEQFRKLFIGGLSFETTEESLRNYYEQWGKLTDCVVMRDPASKRSRGFGFVTFSSMAEVDAAMAARPHSIDGRVVEPKRAVAREESGKPGAHVTVKKLFVGGIKEDTEEHHLRDYFEEYGKIDTIEIITDRQSGKKRGFGFVTFDDHDPVDKIVLQKYHTINGHNAEVRKALSRQEMQEVQSSRSGRGGNFGFGDSRGGGGNFGPGPGSNFRGGSDGYGSGRGFGDGYNGYGGGPGGGNFGGSPGYGGGRGGYGGGGPGYGNQGGGYGGGYDNYGGGNYGSGNYNDFGNYNQQPSNYGPMKSGNFGGSRNMGGPYGGGNYGPGGSGGSGGYGGRSRY DIP protein P22626 original sequence version: 152 DIP protein P22626 original sequence version: 159 4C2560A3D8E99D62 ubiq_human UBIQ_HUMAN protein protein human Homo sapiens Human MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQQRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG vhl_human von Hippel-Lindau disease tumor suppressor VHL pVHL Protein G7 protein protein human Homo sapiens Human MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPRPVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFRDAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDIVRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD DIP protein P40337 original sequence version: 176 DIP protein P40337 original sequence version: 103 DIP protein P40337-1 original sequence version: 177 DIP protein P40337 original sequence version: 160 DIP protein P40337 original sequence version: 175 BA5D6765FBC16EA7 ilf3_human Interleukin enhancer-binding factor 3 ILF3 MPHOSPH4 NF90 Nuclear factor of activated T-cells 90 kDa Double-stranded RNA-binding protein 76 Translational control protein 80 Nuclear factor associated with dsRNA M-phase phosphoprotein 4 DRBF protein protein human Homo sapiens Human MRPMRIFVNDDRHVMAKHSSVYPTQEELEAVQNMVSHTERALKAVSDWIDEQEKGSSEQAESDNMDVPPEDDSKEGAGEQKTEHMTRTLRGVMRVGLVAKGLLLKGDLDLELVLLCKEKPTTALLDKVADNLAIQLAAVTEDKYEILQSVDDAAIVIKNTKEPPLSLTIHLTSPVVREEMEKVLAGETLSVNDPPDVLDRQKCLAALASLRHAKWFQARANGLKSCVIVIRVLRDLCTRVPTWGPLRGWPLELLCEKSIGTANRPMGAGEALRRVLECLASGIVMPDGSGIYDPCEKEATDAIGHLDRQQREDITQSAQHALRLAAFGQLHKVLGMDPLPSKMPKKPKNENPVDYTVQIPPSTTYAITPMKRPMEEDGEEKSPSKKKKKIQKKEEKAEPPQAMNALMRLNQLKPGLQYKLVSQTGPVHAPIFTMSVEVDGNSFEASGPSKKTAKLHVAVKVLQDMGLPTGAEGRDSSKGEDSAEETEAKPAVVAPAPVVEAVSTPSAAFPSDATAEQGPILTKHGKNPVMELNEKRRGLKYELISETGGSHDKRFVMEVEVDGQKFQGAGSNKKVAKAYAALAALEKLFPDTPLALDANKKKRAPVPVRGGPKFAAKPHNPGFGMGGPMHNEVPPPPNLRGRGRGGSIRGRGRGRGFGGANHGGYMNAGAGYGSYGYGGNSATAGYSQFYSNGGHSGNASGGGGGGGGGSSGYGSYYQGDNYNSPVPPKHAGKKQPHGGQQKPSYGSGYQSHQGQQQSYNQSPYSNYGPPQGKQKGYNHGQGSYSYSNSYNSPGGGGGSDYNYESKFNYSGSGGRSGGNSYGSGGASYNPGSHGGYGGGSGGGSSYQGKQGGYSQSNYNSPGSGQNYSGPPSSYQSSQGGYGRNADHSMNYQYR DIP protein Q12906 original sequence version: 87 DIP protein Q12906 original sequence version: 149 20903ABD0331F370 p14866-1 Heterogeneous nuclear ribonucleoprotein L HNRNPL HNRPL P/OKcl.14 protein protein human Homo sapiens Human MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS DIP protein P14866-1 original sequence version: 145 hnrpl_human Heterogeneous nuclear ribonucleoprotein L HNRPL HNRNPL P/OKcl.14 protein protein human Homo sapiens Human MSRRLLPRAEKRRRRLEQRQQPDEQRRRSGAMVKMAAAGGGGGGGRYYGGGSEGGRAPKRLKTDNAGDQHGGGGGGGGGAGAAGGGGGGENYDDPHKTPASPVVHIRGLIDGVVEADLVEALQEFGPISYVVVMPKKRQALVEFEDVLGACNAVNYAADNQIYIAGHPAFVNYSTSQKISRPGDSDDSRSVNSVLLFTILNPIYSITTDVLYTICNPCGPVQRIVIFRKNGVQAMVEFDSVQSAQRAKASLNGADIYSGCCTLKIEYAKPTRLNVFKNDQDTWDYTNPNLSGQGDPGSNPNKRQRQPPLLGDHPAEYGGPHGGYHSHYHDEGYGPPPPHYEGRRMGPPVGGHRRGPSRYGPQYGHPPPPPPPPEYGPHADSPVLMVYGLDQSKMNCDRVFNVFCLYGNVEKVKFMKSKPGAAMVEMADGYAVDRAITHLNNNFMFGQKLNVCVSKQPAIMPGQSYGLEDGSCSYKDFSESRNNRFSTPEQAAKNRIQHPSNVLHFFNAPLEVTEENFFEICDELGVKRPSSVKVFSGKSERSSSGLLEWESKSDALETLGFLNHYQMKNPNGPYPYTLKLCFSTAQHAS DIP protein P14866 original sequence version: 145 31EEB51AF1C65F83 hnrnpl-hnrnpa2b1-1 9 14 unspecified role unspecified role prey prey human Homo sapiens Human 17 unspecified role unspecified role prey prey human Homo sapiens Human 19 unspecified role unspecified role bait bait human Homo sapiens Human association association hnrnpl-hnrnpa2b1-2 13 14 unspecified role unspecified role prey prey human Homo sapiens Human 18 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined P14866-1:p.Tyr359Asp Y359D mutation increasing strength mutation increasing interaction strength mutation increasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain Y D This feature has been corrected as a result of our quality control procedures. The original label was 'Y359D'. Wed May 02 17:25:51 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'tyr359asp' Tue Jun 30 17:38:08 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Tyr359Asp' human Homo sapiens Human physical association physical association hnrnpl-hnrnpa2b1-3 6 14 unspecified role unspecified role prey prey human Homo sapiens Human 19 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association hnrnpl-ub-1 4 15 unspecified role unspecified role prey prey human Homo sapiens Human 19 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association hnrnpl-hnrnpa2b1-4 5 18 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecolx Escherichia coli 14 unspecified role unspecified role prey prey ecolx Escherichia coli 17 unspecified role unspecified role prey prey ecolx Escherichia coli association association hnrnpl-ub-2 7 15 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal human Homo sapiens Human 19 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association hnrnpa2b1-hnrnpl-1 12 14 unspecified role unspecified role bait bait human Homo sapiens Human 18 unspecified role unspecified role prey prey 35S-label 35S-label 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Region 270-383 Region 270-383 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro physical association physical association hnrnpl-ub-3 1 15 unspecified role unspecified role prey prey Biotin-tag Biotin-tag biotin tag biotin tag n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal n-terminal n-terminal position amino-terminus n-terminus n-term n-term amino-terminus n-terminus n-terminal ecolx Escherichia coli 18 unspecified role unspecified role bait bait His-tag His-tag his tag his tag Hexa-His-tag 6-His-tag Histidine-tag Hexa-His-tag Histidine-tag 6-His-tag undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined ecolx Escherichia coli physical association physical association hnrnpa2b1-hnrnpl-2 10 18 unspecified role unspecified role prey prey ecolx Escherichia coli 14 unspecified role unspecified role bait bait GST-tag GST-tag gst tag glutathione s tranferase tag glutathione S-tranferase tag glutathione S-tranferase tag gst tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range ecolx Escherichia coli direct interaction direct interaction ilf3-hnrnpl-1 2 17 unspecified role unspecified role bait bait human Homo sapiens Human 18 unspecified role unspecified role prey prey 35S-label 35S-label 35s radiolabel 35s radiolabel 35S s35 radiolabelled S35 s35 radiolabelled 35S S35 undetermined undetermined sequence position undetermined undetermined undetermined sequence position undetermined Region 383-589 Region 383-589 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain in vitro In vitro physical association physical association ilf3-hnrnpa2b1-1 8 14 unspecified role unspecified role prey prey ecolx Escherichia coli 17 unspecified role unspecified role bait bait ecolx Escherichia coli physical association physical association hnrnpl-vhl-1 3 16 unspecified role unspecified role prey prey human Homo sapiens Human 19 unspecified role unspecified role bait bait human Homo sapiens Human physical association physical association vhl-hnrnpl-1 11 16 unspecified role unspecified role bait bait human Homo sapiens Human 19 unspecified role unspecified role prey prey human Homo sapiens Human physical association physical association