DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS biology 2012 imex curation Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. DIP original experiment: DIP-254662X PLoS biology 2012 IMEx Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS biology 2012 imex curation Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. DIP original experiment: DIP-254664X PLoS biology 2012 IMEx Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS biology 2012 imex curation Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. DIP original experiment: DIP-254663X PLoS biology 2012 IMEx Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS biology 2012 imex curation Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. DIP original experiment: DIP-254665X PLoS biology 2012 IMEx Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS biology 2012 imex curation Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip predetermined predetermined participant predetermined Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. DIP original experiment: DIP-254661X PLoS biology 2012 IMEx Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. PLoS biology 2012 imex curation Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. Only protein-protein interactions drome Drosophila melanogaster (Fruit fly) Fruit fly anti tag coip anti tag coimmunoprecipitation anti tag coip anti tag western anti tag western blot anti tag western Huang HL., Wang S., Yin MX., Dong L., Wang C., Wu W., Lu Y., Feng M., Dai C., Guo X., Li L., Zhao B., Zhou Z., Ji H., Jiang J., Zhao Y., Liu XY., Zhang L. DIP original experiment: DIP-254660X PLoS biology 2012 IMEx Par-1 regulates tissue growth by influencing hippo phosphorylation status and hippo-salvador association. hippo_drome Serine/threonine-protein kinase hippo hpo dMST Drosophila homolog of MST1 and MST2 STE20-like kinase MST CG11228 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MSEPEVTSVVDMKSPNISSSCSFFKLKKLSEESLLQPPEKVFDIMYKLGEGSYGSVYKAVHKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGAGSVSDIMRLRKKTLTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIEEIGYDCVADIWSLGITALEMAEGKPPYGEIHPMRAIFMIPQKPPPSFREPDRWSTEFIDFVSKCLVKEPDDRATATELLEHEFIRNAKHRSILKPMLEETCAIREQQRANRSFGGVLAASQAKSLATQENGMQQHITDNAFMEDPGTLVPEKFGEYQQSSASDATMIAHAEQGVDEGTLGPGGLRNLSKAAAPAAASSAASPLDMPAVDSGTMVELESNLGTMVINSDSDDSTTAKNNDDQKPRNRYRPQFLEHFDRKNAGDGRGDEKPIATEYSPAAAEQQQQQQQQQQQQQQDEQHLASGANDLNNWEHNMEMQFQQISAINQYGLQQHQQQQQVLMAYPLMNEQLIALNNQPNLLLSNAAPMGQQGIPAAAPAQPPPAYQNQHMHTQSHAYVEGEFEFLKFLTFDDLNQRLCNIDHEMELEIEQLNKKYNAKRQPIVDAMNAKRKRQQNINNNLIKI DIP protein Q8T0S6 original sequence version: 100 B3DDDFAF5F4E4EB3 q6npa6_drome par-1 CG30132 27C1 BcDNA:RH48823 CG11960 CG16701 CG30131 DPAR-1 DPar1 Dmel\CG8201 EMK MARK PAR-1 PAR1 Par-1 Par1 anon-WO0210402.19 dMARK dPAR-1 dPAR1 dPar-1 dPar1 l(2)27C1 l(2)k06323 par1 CG8201 Dmel_CG8201 protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MSTAMRTTLQSVPEALPADSVSNGTASNVAAPAAPVSSATNAVPPLAAVSSTTATYATNSISTSSHSVKDQQQQQQQQQHDSANANIVSLPPTTTPVANTNTMMPIVTSSNSATSNSTAATPTPASGAAATGGVGSVSQGPATVSASAANTNHSHQHSHQHHHHVANNMTTDGARLSSNNSAVVASSAINHHHHHTPGSGVAPTVNKNVLSTHSAHPSAIKQRTSSAKGSPNMQMRSSAPMRWRATEEHIGKYKLIKTIGKGNFAKVKLAKHLPTGKEVAIKIIDKTQLNPGSLQKLFREVRIMKMLDHPNIVKLFQVIETEKTLYLIMEYASGGEVFDYLVLHGRMKEKEARVKFRQIVSAVQYCHQKRIIHRDLKAENLLLDSELNIKIADFGFSNEFTPGSKLDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGSTLRELRERVLRGKYRIPFYMSTDCENLLRKFLVLNPAKRASLETIMGDKWMNMGFEEDELKPYIEPKADLADPKRIEALVAMGYNRSEIEASLSQVRYDDVFATYLLLGRKSTDPESDGSRSGSSLSLRNISGNDAGANAGSASVQSPTHRGVHRSISASSTKPSRRASSGVGPTNAAATVAAATGAVGAVNPSNNYNAAGSAADRASVGSNFKRQNTIDSATIKENTARLAAQNQRPASATQKMLTTADTTLNSPAKPRTATKYDPTNGNRTVSGTSGIIPRRSTTLYEKTSSTEKTNVIPAETNLFDRLRMASAVKSSRHFPRNVPSRSTFHSGQTRARNNTALEYSGTSGASGDSSHPGRMSFFSKLSSRFSKRPNQ DIP protein Q6NPA6 original sequence version: 99 147DF52F257D540A sav_drome Scaffold protein salvador sav SHRP CG33193 Shar-pei protein protein drome Drosophila melanogaster (Fruit fly) Fruit fly MNYLTILLCNRKPTMLSRRNKEKSQHKEGVVGKYMKKDTPPDISVINVWSDQRAKKKSLQRCASTSPSCEFHPRSSSTSRNTYSCTDSQPDYYHARRAQSQMPLQQHSHSHPHSLPHPSHPHVRSHPPLPPHQFRASSNQLSQNSSNYVNFEQIERMRRQQSSPLLQTTSSPAPGAGGFQRSYSTTQRQHHPHLGGDSYDADQGLLSASYANMLQLPQRPHSPAHYAVPPQQQQHPQIHQQHASTPFGSTLRFDRAAMSIRERQPRYQPTSSPMQQQQQQQQQQQQQLQHTQLAAHLGGSYSSDSYPIYENPSRVISMRATQSQRSESPIYSNTTASSATLAVVPQHHHQGHLAVPSGSGGGSLSGSGRGGSSGSVRGASTSVQSLYVPPRTPPSAVAGAGGSANGSLQKVPSQQSLTEPEELPLPPGWATQYTLHGRKYYIDHNAHTTHWNHPLEREGLPVGWRRVVSKMHGTYYENQYTGQSQRQHPCLTSYYVYTTSAEPPKAIRPEASLYAPPTHTHNALVPANPYLLEEIPKWLAVYSEADSSKDHLLQFNMFSLPELEGFDSMLVRLFKQELGTIVGFYERYRRALILEKNRRAGQNQNQNQ DIP protein Q9VCR6 original sequence version: 95 05DF47686EE3335E hpo-par_1-1 6 8 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range drome Drosophila melanogaster (Fruit fly) Fruit fly 7 unspecified role unspecified role bait bait Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association hpo-par_1-2 1 8 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range Region 1-562 Region 1-562 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly 7 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association sav-par_1-1 2 9 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range drome Drosophila melanogaster (Fruit fly) Fruit fly 8 unspecified role unspecified role prey prey HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range Region 1-562 Region 1-562 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association par_1-hpo-1 3 8 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range Region 1-562 Region 1-562 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain Region 563-833 Region 563-833 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly 7 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association sav-hpo-3 5 9 unspecified role unspecified role bait bait Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range drome Drosophila melanogaster (Fruit fly) Fruit fly 7 unspecified role unspecified role prey prey drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association par_1-sav-1 4 9 unspecified role unspecified role prey prey Myc-tag Myc-tag myc tag myc tag EUKLISEED epitope tag EUKLISEED epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range drome Drosophila melanogaster (Fruit fly) Fruit fly 8 unspecified role unspecified role bait bait HA-tag HA-tag ha tag ha tag YPYDVPDYA epitope tag YPYDVPDYA epitope tag n-term range n-terminal range n-term range n-term range n-terminal range n-term range Region 1-562 Region 1-562 sufficient to bind sufficient binding region sufficient to bind deletion analysis deletion analysis certain certain sequence position certain certain certain sequence position certain drome Drosophila melanogaster (Fruit fly) Fruit fly physical association physical association