DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nature cell biology 2013 imex curation Li H., Alavian KN., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman RS., Morrison RS., Jonas EA. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li H., Alavian KN., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman RS., Morrison RS., Jonas EA. DIP original experiment: DIP-259910X Nature cell biology 2013 IMEx A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nature cell biology 2013 imex curation Li H., Alavian KN., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman RS., Morrison RS., Jonas EA. Only protein-protein interactions human Homo sapiens Human anti tag coip anti tag coimmunoprecipitation anti tag coip western blot western blot Immuno blot Immuno blot Li H., Alavian KN., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman RS., Morrison RS., Jonas EA. DIP original experiment: DIP-259912X Nature cell biology 2013 IMEx A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nature cell biology 2013 imex curation Li H., Alavian KN., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman RS., Morrison RS., Jonas EA. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li H., Alavian KN., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman RS., Morrison RS., Jonas EA. DIP original experiment: DIP-259909X Nature cell biology 2013 IMEx A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nature cell biology 2013 imex curation Li H., Alavian KN., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman RS., Morrison RS., Jonas EA. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li H., Alavian KN., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman RS., Morrison RS., Jonas EA. DIP original experiment: DIP-259908X Nature cell biology 2013 IMEx A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. Nature cell biology 2013 imex curation Li H., Alavian KN., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman RS., Morrison RS., Jonas EA. Only protein-protein interactions rat Rattus norvegicus (Rat) Rat anti bait coip anti bait coimmunoprecipitation anti bait coip western blot western blot Immuno blot Immuno blot Li H., Alavian KN., Lazrove E., Mehta N., Jones A., Zhang P., Licznerski P., Graham M., Uo T., Guo J., Rahner C., Duman RS., Morrison RS., Jonas EA. DIP original experiment: DIP-259911X Nature cell biology 2013 IMEx A Bcl-xL-Drp1 complex regulates synaptic vesicle membrane dynamics during endocytosis. syt1_rat Synaptotagmin-1 Syt1 Synaptotagmin I p65 protein protein rat Rattus norvegicus (Rat) Rat MVSASHPEALAAPVTTVATLVPHNATEPASPGEGKEDAFSKLKQKFMNELHKIPLPPWALIAIAIVAVLLVVTCCFCVCKKCLFKKKNKKKGKEKGGKNAINMKDVKDLGKTMKDQALKDDDAETGLTDGEEKEEPKEEEKLGKLQYSLDYDFQNNQLLVGIIQAAELPALDMGGTSDPYVKVFLLPDKKKKFETKVHRKTLNPVFNEQFTFKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGHVTEEWRDLQSAEKEEQEKLGDICFSLRYVPTAGKLTVVILEAKNLKKMDVGGLSDPYVKIHLMQNGKRLKKKKTTIKKNTLNPYYNESFSFEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRHWSDMLANPRRPIAQWHTLQVEEEVDAMLAVKK DIP protein P21707 original sequence version: 71 DIP protein P21707 original sequence version: 76 DIP protein P21707 original sequence version: 141 DIP protein P21707 original sequence version: 112 DIP protein P21707 original sequence version: 145 DIP protein P21707 original sequence version: 160 06CE28F04C97A722 dnm1l_rat Dynamin-1-like protein Dnm1l Dlp1 Drp1 Dynamin-like protein protein protein rat Rattus norvegicus (Rat) Rat MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGVVTRRPLILQLVHVSPEDKRKTTGEENDPATWKNSRHLSKGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKVFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDNRRETKNVASAGGGIGDGGRIGDGGQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW DIP protein O35303 original sequence version: 51 0568353907794C43 clca_rat Clathrin light chain A Clta protein protein rat Rattus norvegicus (Rat) Rat MAELDPFGAPAGAPGGPALGNGVAGAGEEDPAAAFLAQQESEIAGIENDEAFAILDGGAPGPQAHGEPPGGPDAVDGVMNGEYYQESNGPTDSYAAISEVDRLQSEPESIRKWREEQTERLEALDANSRKQEAEWKEKAVKELEEWYARQDEQLQKTKASNRVADEAFYKQPFADVIGYVTNINHPCYSLEQAAEEAFVNDIDESSPGTEWERVARLCDFNPKSSKQAKDVSRMRSVLISLKQAPLVH DIP protein P08081 original sequence version: 101 C939E85B0FD2E124 o00429-1 Dynamin-1-like protein DNM1L DLP1 DRP1 Dnm1p/Vps1p-like protein Dynamin family member proline-rich carboxyl-terminal domain less Dynamin-like protein Dynamin-like protein 4 Dynamin-like protein IV Dynamin-related protein 1 DLP1F HdynIV-WT protein protein human Homo sapiens Human MEALIPVINKLQDVFNTVGADIIQLPQIVVVGTQSSGKSSVLESLVGRDLLPRGTGIVTRRPLILQLVHVSQEDKRKTTGEENGVEAEEWGKFLHTKNKLYTDFDEIRQEIENETERISGNNKGVSPEPIHLKIFSPNVVNLTLVDLPGMTKVPVGDQPKDIELQIRELILRFISNPNSIILAVTAANTDMATSEALKISREVDPDGRRTLAVITKLDLMDAGTDAMDVLMGRVIPVKLGIIGVVNRSQLDINNKKSVTDSIRDEYAFLQKKYPSLANRNGTKYLARTLNRLLMHHIRDCLPELKTRINVLAAQYQSLLNSYGEPVDDKSATLLQLITKFATEYCNTIEGTAKYIETSELCGGARICYIFHETFGRTLESVDPLGGLNTIDILTAIRNATGPRPALFVPEVSFELLVKRQIKRLEEPSLRCVELVHEEMQRIIQHCSNYSTQELLRFPKLHDAIVEVVTCLLRKRLPVTNEMVHNLVAIELAYINTKHPDFADACGLMNNNIEEQRRNRLARELPSAVSRDKSSKVPSALAPASQEPSPAASAEADGKLIQDSRRETKNVASGGGGVGDGVQEPTTGNWRGMLKTSKAEELLAEEKSKPIPIMPASPQKGHAVNLLDVPVPVARKLSAREQRDCEVIERLIKSYFLIVRKNIQDSVPKAVMHFLVNHVKDTLQSELVGQLYKSSLLDDLLTESEDMAQRRKEAADMLKALQGASQIIAEIRETHLW DIP protein O00429-1 original sequence version: 192 DIP protein O00429 original sequence version: 122 q07817-1 Bcl-2-like protein 1 BCLX Apoptosis regulator Bcl-X BCL2L1 BCL2L Bcl-xL protein protein human Homo sapiens Human MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK DIP protein Q07817 original sequence version: 82 DIP protein Q07817 original sequence version: 86 DIP protein Q07817-1 original sequence version: 100 DIP protein Q07817-1 original sequence version: 108 DIP protein Q07817 original sequence version: 131 DIP protein Q07817-1 original sequence version: 110 DIP protein Q07817-1 original sequence version: 135 DIP protein Q07817-1 original sequence version: 131 DIP protein Q07817-1 original sequence version: 172 DIP protein Q07817-1 original sequence version: 174 DIP protein Q07817 original sequence version: 174 DIP protein Q07817-1 original sequence version: 189 DIP protein Q07817-1 original sequence version: 192 DIP protein Q07817 original sequence version: 190 E09D3CDD851AE9BE p53563-1 Bcl-2-like protein 1 Bcl-xL Bcl2l1 Bclx Blc2l Apoptosis regulator Bcl-X protein protein rat Rattus norvegicus (Rat) Rat MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEETEPERETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIASWMATYLNDHLEPWIQENGGWDTFVDLYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK DIP protein P53563-1 original sequence version: 81 DIP protein P53563 original sequence version: 135 2B62B6C63864BC8F mff_rat Mitochondrial fission factor Mff protein protein rat Rattus norvegicus (Rat) Rat MAEISRIQYEMEYTEGISQRMRVPEKLKVAPPNADLEQGFQDGVPNASVIMQVPERIVVTGNNEDISFSRPADLDLIQSTPFKPLALKTPPRVLTLSERPLDFLDLERPPPTPQSEEIRAVGRLKRERSMSENAVRQNGQLVRNDSMYGISSLDAAVEGASEDMSVVDAASLRRQIIKLNRRLQLLEEENKERAKREMVMYSITVAFWLLNSWLWFRR DIP protein Q4KM98 original sequence version: 56 rdrp1-bcl2l1-1 4 11 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 8 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 12 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 7 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat association association bcl2l1-dnm1l-4 2 9 unspecified role unspecified role prey prey human Homo sapiens Human 10 unspecified role unspecified role bait bait Q07817-1:p.[Trp188Ser;Asp189Val;Phe191Cys] W188S/D189V/F191C mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F C certain certain sequence position certain certain certain sequence position certain D V certain certain sequence position certain certain certain sequence position certain W S This feature has been corrected as a result of our quality control procedures. The original label was 'W188S/D189V/F191C'. Wed May 02 14:29:01 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'trp188ser,asp189val,phe191cys' Tue Jun 30 18:26:56 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Trp188Ser;Asp189Val;Phe191Cys]' Flag-tag Flag-tag flag tag flag tag FLAG-tagged FLAG DYKDDDDKV epitope tag DYKDDDDKV epitope tag FLAG FLAG-tagged n-term range n-terminal range n-term range n-term range n-terminal range n-term range human Homo sapiens Human physical association physical association syt1-mff-1 1 6 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 12 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat physical association physical association clta-bcl2l1-1 5 11 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 8 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat physical association physical association bcl2l1-clta-1 3 11 unspecified role unspecified role bait bait rat Rattus norvegicus (Rat) Rat 8 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 12 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat 7 unspecified role unspecified role prey prey rat Rattus norvegicus (Rat) Rat association association