DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structure (London, England : 1993) 2013 imex curation Hatherley D., Lea SM., Johnson S., Barclay AN. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Hatherley D., Lea SM., Johnson S., Barclay AN. DIP original experiment: DIP-252276X Structure (London, England : 1993) 2013 IMEx Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structure (London, England : 1993) 2013 imex curation Hatherley D., Lea SM., Johnson S., Barclay AN. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Hatherley D., Lea SM., Johnson S., Barclay AN. DIP original experiment: DIP-252275X Structure (London, England : 1993) 2013 IMEx Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structure (London, England : 1993) 2013 imex curation Hatherley D., Lea SM., Johnson S., Barclay AN. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Hatherley D., Lea SM., Johnson S., Barclay AN. DIP original experiment: DIP-252277X Structure (London, England : 1993) 2013 IMEx Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. Structure (London, England : 1993) 2013 imex curation Hatherley D., Lea SM., Johnson S., Barclay AN. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Hatherley D., Lea SM., Johnson S., Barclay AN. DIP original experiment: DIP-252274X Structure (London, England : 1993) 2013 IMEx Structures of CD200/CD200 receptor family and implications for topology, regulation, and evolution. mo2r4_mouse Cell surface glycoprotein CD200 receptor 4 Cd200r4 CD200 cell surface glycoprotein receptor-like 4 CD200 cell surface glycoprotein receptor-like a Cell surface glycoprotein OX2 receptor 4 protein protein mouse Mus musculus Mouse MHALGRIPTLTLLIFINIFVSGSSCTDENQTIQNDSSSSLTQVNTTMSVQMDKKALLCCFSSPLINAVLITWIIKHRHLPSCTIAYNLDKKTNETSCLGRNITWASTPDHSPELQISAVALQHEGTYTCEIVTPEGNLEKVYDLQVLVPPEVTYFPGKNRTAVCEAMAGKPAAQISWTPDGDCVTKSESHSNGTVTVRSTCHWEQNNVSVVSCLVSHSTGNQSLSIELSQGTMTTPRSLLTILYVKMALLVIILLNVGFAFFQKRNFART DIP protein Q6XJV4 original sequence version: 78 ox2g_mouse OX-2 membrane glycoprotein Cd200 Mox2 MRC OX-2 antigen protein protein mouse Mus musculus Mouse MGSLVFRRPFCHLSTYSLIWGMAAVALSTAQVEVVTQDERKALHTTASLRCSLKTSQEPLIVTWQKKKAVSPENMVTYSKTHGVVIQPAYKDRINVTELGLWNSSITFWNTTLEDEGCYMCLFNTFGSQKVSGTACLTLYVQPIVHLHYNYFEDHLNITCSATARPAPAISWKGTGTGIENSTESHFHSNGTTSVTSILRVKDPKTQVGKEVICQVLYLGNVIDYKQSLDKGFWFSVPLLLSIVSLVILLVLISILLYWKRHRNQERGESSQGMQRMK DIP protein O54901 original sequence version: 101 mint Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues 0D06A2DE0C60DF5A mo2r1_mouse Cell surface glycoprotein CD200 receptor 1 Cd200r1 Mox2r Ox2r CD200 cell surface glycoprotein receptor Cell surface glycoprotein OX2 receptor 1 protein protein mouse Mus musculus Mouse MFCFWRTSALAVLLIWGVFVAGSSCTDKNQTTQNNSSSPLTQVNTTVSVQIGTKALLCCFSIPLTKAVLITWIIKLRGLPSCTIAYKVDTKTNETSCLGRNITWASTPDHSPELQISAVTLQHEGTYTCETVTPEGNFEKNYDLQVLVPPEVTYFPEKNRSAVCEAMAGKPAAQISWSPDGDCVTTSESHSNGTVTVRSTCHWEQNNVSDVSCIVSHLTGNQSLSIELSRGGNQSLRPYIPYIIPSIIILIIIGCICLLKISGFRKCKLPKLEATSAIEEDEMQPYASYTEKSNPLYDTVTKVEAFPVSQGEVNGTDCLTLSAIGI DIP protein Q9ES57 original sequence version: 99 cd200r4-cd200-1 1 6 unspecified role unspecified role prey prey Extracellular domain Region 31-232 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 5 unspecified role unspecified role bait bait Extracellular domain Region 26-237 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Q6XJV4:p.[Asn87Lys;Lys90Thr;Leu138Phe] N87K/K90T/L138F mutation increasing strength mutation increasing interaction strength mutation increasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K T certain certain sequence position certain certain certain sequence position certain N K certain certain sequence position certain certain certain sequence position certain L F This feature has been corrected as a result of our quality control procedures. The original label was 'N87K/K90T/L138F'. Wed May 02 15:06:02 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn87lys,lys90thr,leu138phe' Tue Jun 30 16:02:32 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Asn87Lys;Lys90Thr;Leu138Phe]' Q6XJV4:p.Leu138Phe L138F mutation increasing strength mutation increasing interaction strength mutation increasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L F This feature has been corrected as a result of our quality control procedures. The original label was 'L138F'. Wed May 02 15:29:39 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu138phe' Tue Jun 30 18:13:22 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu138Phe' Q6XJV4:p.[Asn87Lys;Lys90Thr] N87K/K90T mutation increasing strength mutation increasing interaction strength mutation increasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K T certain certain sequence position certain certain certain sequence position certain N K This feature has been corrected as a result of our quality control procedures. The original label was 'N87K/K90T'. Wed May 02 18:33:46 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn87lys,lys90thr' Tue Jun 30 17:53:13 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Asn87Lys;Lys90Thr]' human Homo sapiens Human direct interaction direct interaction cd200-cd200r1-1 4 6 unspecified role unspecified role unspecified role unspecified role Extracellular domain Region 31-232 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 7 unspecified role unspecified role unspecified role unspecified role Extracellular domain Region 26-232 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster direct interaction direct interaction cd200r1-cd200-1 2 6 unspecified role unspecified role prey prey Extracellular domain Region 31-232 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster 7 unspecified role unspecified role bait bait Extracellular domain Region 26-232 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction cd200-cd200r1-2 3 6 unspecified role unspecified role bait bait Extracellular domain Region 31-232 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain O54901:p.Asn74Asp N74D mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain N D This feature has been corrected as a result of our quality control procedures. The original label was 'N74D'. Wed May 02 14:31:47 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn74asp' Tue Jun 30 16:55:12 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn74Asp' O54901:p.Asn74Ala N74A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain N A This feature has been corrected as a result of our quality control procedures. The original label was 'N74A'. Wed May 02 16:35:40 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn74ala' Tue Jun 30 18:43:21 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn74Ala' O54901:p.Leu60Lys L60K mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain L K This feature has been corrected as a result of our quality control procedures. The original label was 'L60K'. Wed May 02 15:32:51 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu60lys' Tue Jun 30 19:15:38 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu60Lys' O54901:p.Ile61Glu I61E mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain I E This feature has been corrected as a result of our quality control procedures. The original label was 'I61E'. Wed May 02 14:34:04 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'ile61glu' Tue Jun 30 19:08:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Ile61Glu' O54901:p.Leu122Ala L122A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain L A This feature has been corrected as a result of our quality control procedures. The original label was 'L122A'. Wed May 02 15:27:30 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu122ala' Tue Jun 30 19:08:49 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Leu122Ala' O54901:p.Asn124Lys N124K mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain N K This feature has been corrected as a result of our quality control procedures. The original label was 'N124K'. Wed May 02 15:44:11 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'asn124lys' Tue Jun 30 18:35:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Asn124Lys' O54901:p.Phe126Asp F126D mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F D This feature has been corrected as a result of our quality control procedures. The original label was 'F126D'. Wed May 02 18:48:54 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe126asp' Tue Jun 30 20:00:35 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe126Asp' O54901:p.Phe126Ala F126A mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength alanine scanning alanine scanning certain certain sequence position certain certain certain sequence position certain F A This feature has been corrected as a result of our quality control procedures. The original label was 'F126A'. Wed May 02 19:50:59 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe126ala' Tue Jun 30 16:58:36 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe126Ala' O54901:p.Lys130Glu K130E mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain K E This feature has been corrected as a result of our quality control procedures. The original label was 'K130E'. Wed May 02 17:25:15 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'lys130glu' Tue Jun 30 16:18:41 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Lys130Glu' human Homo sapiens Human 7 unspecified role unspecified role prey prey Extracellular domain Region 26-232 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain crigr Cricetulus griseus (Chinese hamster) Cricetulus barabensis griseus Chinese hamster direct interaction direct interaction