DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 2013 imex curation Raj VS., Mou H., Smits SL., Dekkers DH., Müller MA., Dijkman R., Muth D., Demmers JA., Zaki A., Fouchier RA., Thiel V., Drosten C., Rottier PJ., Osterhaus AD., Bosch BJ., Haagmans BL. Coronavirus - Interactions investigated in the context of Coronavirus Only protein-protein interactions in vitro In vitro pull down pull down weight by staining molecular weight estimation by staining weight by staining Raj VS., Mou H., Smits SL., Dekkers DH., Müller MA., Dijkman R., Muth D., Demmers JA., Zaki A., Fouchier RA., Thiel V., Drosten C., Rottier PJ., Osterhaus AD., Bosch BJ., Haagmans BL. Coronavirus - Interactions investigated in the context of Coronavirus DIP original experiment: DIP-252821X Nature 2013 IMEx Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 2013 imex curation Raj VS., Mou H., Smits SL., Dekkers DH., Müller MA., Dijkman R., Muth D., Demmers JA., Zaki A., Fouchier RA., Thiel V., Drosten C., Rottier PJ., Osterhaus AD., Bosch BJ., Haagmans BL. Coronavirus - Interactions investigated in the context of Coronavirus Only protein-protein interactions human Homo sapiens Human comigration in sds comigration in sds page comigration in sds weight by staining molecular weight estimation by staining weight by staining Raj VS., Mou H., Smits SL., Dekkers DH., Müller MA., Dijkman R., Muth D., Demmers JA., Zaki A., Fouchier RA., Thiel V., Drosten C., Rottier PJ., Osterhaus AD., Bosch BJ., Haagmans BL. Coronavirus - Interactions investigated in the context of Coronavirus DIP original experiment: DIP-252824X Nature 2013 IMEx Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 2013 imex curation Raj VS., Mou H., Smits SL., Dekkers DH., Müller MA., Dijkman R., Muth D., Demmers JA., Zaki A., Fouchier RA., Thiel V., Drosten C., Rottier PJ., Osterhaus AD., Bosch BJ., Haagmans BL. Coronavirus - Interactions investigated in the context of Coronavirus Only protein-protein interactions in vitro In vitro pull down pull down weight by staining molecular weight estimation by staining weight by staining Raj VS., Mou H., Smits SL., Dekkers DH., Müller MA., Dijkman R., Muth D., Demmers JA., Zaki A., Fouchier RA., Thiel V., Drosten C., Rottier PJ., Osterhaus AD., Bosch BJ., Haagmans BL. Coronavirus - Interactions investigated in the context of Coronavirus DIP original experiment: DIP-252822X Nature 2013 IMEx Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 2013 imex curation Raj VS., Mou H., Smits SL., Dekkers DH., Müller MA., Dijkman R., Muth D., Demmers JA., Zaki A., Fouchier RA., Thiel V., Drosten C., Rottier PJ., Osterhaus AD., Bosch BJ., Haagmans BL. Coronavirus - Interactions investigated in the context of Coronavirus Only protein-protein interactions human Homo sapiens Human comigration in sds comigration in sds page comigration in sds weight by staining molecular weight estimation by staining weight by staining Raj VS., Mou H., Smits SL., Dekkers DH., Müller MA., Dijkman R., Muth D., Demmers JA., Zaki A., Fouchier RA., Thiel V., Drosten C., Rottier PJ., Osterhaus AD., Bosch BJ., Haagmans BL. Coronavirus - Interactions investigated in the context of Coronavirus DIP original experiment: DIP-252823X Nature 2013 IMEx Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. Nature 2013 imex curation Raj VS., Mou H., Smits SL., Dekkers DH., Müller MA., Dijkman R., Muth D., Demmers JA., Zaki A., Fouchier RA., Thiel V., Drosten C., Rottier PJ., Osterhaus AD., Bosch BJ., Haagmans BL. Coronavirus - Interactions investigated in the context of Coronavirus Only protein-protein interactions in vitro In vitro pull down pull down de novo protein sequence de novo protein sequencing by mass spectrometry de novo protein sequence Raj VS., Mou H., Smits SL., Dekkers DH., Müller MA., Dijkman R., Muth D., Demmers JA., Zaki A., Fouchier RA., Thiel V., Drosten C., Rottier PJ., Osterhaus AD., Bosch BJ., Haagmans BL. Coronavirus - Interactions investigated in the context of Coronavirus DIP original experiment: DIP-252820X Nature 2013 IMEx Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC. k0brg7_mers Spike glycoprotein E2 Peplomer protein S protein protein cv2ce Human betacoronavirus 2c EMC/2012 MIHSVFLLMFLLTPTESYVDVGPDSVKSACIEVDIQQTFFDKTWPRPIDVSKADGIIYPQGRTYSNITITYQGLFPYQGDHGDMYVYSAGHATGTTPQKLFVANYSQDVKQFANGFVVRIGAAANSTGTVIISPSTSATIRKIYPAFMLGSSVGNFSDGKMGRFFNHTLVLLPDGCGTLLRAFYCILEPRSGNHCPAGNSYTSFATYHTPATDCSDGNYNRNASLNSFKEYFNLRNCTFMYTYNITEDEILEWFGITQTAQGVHLFSSRYVDLYGGNMFQFATLPVYDTIKYYSIIPHSIRSIQSDRKAWAAFYVYKLQPLTFLLDFSVDGYIRRAIDCGFNDLSQLHCSYESFDVESGVYSVSSFEAKPSGSVVEQAEGVECDFSPLLSGTPPQVYNFKRLVFTNCNYNLTKLLSLFSVNDFTCSQISPAAIASNCYSSLILDYFSYPLSMKSDLSVSSAGPISQFNYKQSFSNPTCLILATVPHNLTTITKPLKYSYINKCSRLLSDDRTEVPQLVNANQYSPCVSIVPSTVWEDGDYYRKQLSPLEGGGWLVASGSTVAMTEQLQMGFGITVQYGTDTNSVCPKLEFANDTKIASQLGNCVEYSLYGVSGRGVFQNCTAVGVRQQRFVYDAYQNLVGYYSDDGNYYCLRACVSVPVSVIYDKETKTHATLFGSVACEHISSTMSQYSRSTRSMLKRRDSTYGPLQTPVGCVLGLVNSSLFVEDCKLPLGQSLCALPDTPSTLTPRSVRSVPGEMRLASIAFNHPIQVDQLNSSYFKLSIPTNFSFGVTQEYIQTTIQKVTVDCKQYVCNGFQKCEQLLREYGQFCSKINQALHGANLRQDDSVRNLFASVKSSQSSPIIPGFGGDFNLTLLEPVSISTGSRSARSAIEDLLFDKVTIADPGYMQGYDDCMQQGPASARDLICAQYVAGYKVLPPLMDVNMEAAYTSSLLGSIAGVGWTAGLSSFAAIPFAQSIFYRLNGVGITQQVLSENQKLIANKFNQALGAMQTGFTTTNEAFQKVQDAVNNNAQALSKLASELSNTFGAISASIGDIIQRLDVLEQDAQIDRLINGRLTTLNAFVAQQLVRSESAALSAQLAKDKVNECVKAQSKRSGFCGQGTHIVSFVVNAPNGLYFMHVGYYPSNHIEVVSAYGLCDAANPTNCIAPVNGYFIKTNNTRIVDEWSYTGSSFYAPEPITSLNTKYVAPQVTYQNISTNLPPPLLGNSTGIDFQDELDEFFKNVSTSIPNFGSLTQINTTLLDLTYEMLSLQQVVKALNESYIDLKELGNYTYYNKWPWYIWLGFIAGLVALALCVFFILCCTGCGTNCMGKLKCNRCCDRYEEYDLEPHKVHVH DIP protein K0BRG7 original sequence version: 3 DIP protein K0BRG7 original sequence version: 4 ace2_human Angiotensin-converting enzyme 2 ACE2 UNQ868/PRO1885 Angiotensin-converting enzyme homolog Metalloprotease MPROT15 Angiotensin-converting enzyme-related carboxypeptidase protein protein human Homo sapiens Human MSSSSWLLLSLVAVTAAQSTIEEQAKTFLDKFNHEAEDLFYQSSLASWNYNTNITEENVQNMNNAGDKWSAFLKEQSTLAQMYPLQEIQNLTVKLQLQALQQNGSSVLSEDKSKRLNTILNTMSTIYSTGKVCNPDNPQECLLLEPGLNEIMANSLDYNERLWAWESWRSEVGKQLRPLYEEYVVLKNEMARANHYEDYGDYWRGDYEVNGVDGYDYSRGQLIEDVEHTFEEIKPLYEHLHAYVRAKLMNAYPSYISPIGCLPAHLLGDMWGRFWTNLYSLTVPFGQKPNIDVTDAMVDQAWDAQRIFKEAEKFFVSVGLPNMTQGFWENSMLTDPGNVQKAVCHPTAWDLGKGDFRILMCTKVTMDDFLTAHHEMGHIQYDMAYAAQPFLLRNGANEGFHEAVGEIMSLSAATPKHLKSIGLLSPDFQEDNETEINFLLKQALTIVGTLPFTYMLEKWRWMVFKGEIPKDQWMKKWWEMKREIVGVVEPVPHDETYCDPASLFHVSNDYSFIRYYTRTLYQFQFQEALCQAAKHEGPLHKCDISNSTEAGQKLFNMLRLGKSEPWTLALENVVGAKNMNVRPLLNYFEPLFTWLKDQNKNSFVGWSTDWSPYADQSIKVRISLKSALGDKAYEWNDNEMYLFRSSVAYAMRQYFLKVKNQMILFGEEDVRVANLKPRISFNFFVTAPKNVSDIIPRTEVEKAIRMSRSRINDAFRLNDNSLEFLGIQPTLGPPNQPPVSIWLIVFGVVMGVIVVGIVILIFTGIRDRKKKNKARSGENPYASIDISKGENNPGFQNTDDVQTSF mint Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses 8EE6EB0A931550E8 spike_sars Spike glycoprotein S E2 Peplomer protein 2 protein protein sars-cov Human SARS coronavirus SARS-CoV Severe acute respiratory syndrome coronavirus MFIFLLFLTLTSGSDLDRCTTFDDVQAPNYTQHTSSMRGVYYPDEIFRSDTLYLTQDLFLPFYSNVTGFHTINHTFGNPVIPFKDGIYFAATEKSNVVRGWVFGSTMNNKSQSVIIINNSTNVVIRACNFELCDNPFFAVSKPMGTQTHTMIFDNAFNCTFEYISDAFSLDVSEKSGNFKHLREFVFKNKDGFLYVYKGYQPIDVVRDLPSGFNTLKPIFKLPLGINITNFRAILTAFSPAQDIWGTSAAAYFVGYLKPTTFMLKYDENGTITDAVDCSQNPLAELKCSVKSFEIDKGIYQTSNFRVVPSGDVVRFPNITNLCPFGEVFNATKFPSVYAWERKKISNCVADYSVLYNSTFFSTFKCYGVSATKLNDLCFSNVYADSFVVKGDDVRQIAPGQTGVIADYNYKLPDDFMGCVLAWNTRNIDATSTGNYNYKYRYLRHGKLRPFERDISNVPFSPDGKPCTPPALNCYWPLNDYGFYTTTGIGYQPYRVVVLSFELLNAPATVCGPKLSTDLIKNQCVNFNFNGLTGTGVLTPSSKRFQPFQQFGRDVSDFTDSVRDPKTSEILDISPCSFGGVSVITPGTNASSEVAVLYQDVNCTDVSTAIHADQLTPAWRIYSTGNNVFQTQAGCLIGAEHVDTSYECDIPIGAGICASYHTVSLLRSTSQKSIVAYTMSLGADSSIAYSNNTIAIPTNFSISITTEVMPVSMAKTSVDCNMYICGDSTECANLLLQYGSFCTQLNRALSGIAAEQDRNTREVFAQVKQMYKTPTLKYFGGFNFSQILPDPLKPTKRSFIEDLLFNKVTLADAGFMKQYGECLGDINARDLICAQKFNGLTVLPPLLTDDMIAAYTAALVSGTATAGWTFGAGAALQIPFAMQMAYRFNGIGVTQNVLYENQKQIANQFNKAISQIQESLTTTSTALGKLQDVVNQNAQALNTLVKQLSSNFGAISSVLNDILSRLDKVEAEVQIDRLITGRLQSLQTYVTQQLIRAAEIRASANLAATKMSECVLGQSKRVDFCGKGYHLMSFPQAAPHGVVFLHVTYVPSQERNFTTAPAICHEGKAYFPREGVFVFNGTSWFITQRNFFSPQIITTDNTFVSGNCDVVIGIINNTVYDPLQPELDSFKEELDKYFKNHTSPDVDLGDISGINASVVNIQKEIDRLNEVAKNLNESLIDLQELGKYEQYIKWPWYVWLGFIAGLIAIVMVTILLCCMTSCCSCLKGACSCGSCCKFDEDDSEPVLKGVKLHYT DIP protein P59594 original sequence version: 48 dpp4_human Dipeptidyl peptidase 4 DPP4 ADCP2 CD26 ADABP Adenosine deaminase complexing protein 2 Dipeptidyl peptidase IV T-cell activation antigen CD26 TP103 protein protein human Homo sapiens Human MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP DIP protein P27487 original sequence version: 154 DIP protein P27487 original sequence version: 159 5FB4A2C6662D6117 s-dpp4-1 5 9 unspecified role unspecified role prey prey human Homo sapiens Human 6 unspecified role unspecified role bait bait S1 domain Region 1-747 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human physical association physical association s-ace2-1 3 7 unspecified role unspecified role prey prey Region 1-614 Region 1-614 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 8 unspecified role unspecified role bait bait S1 domain Region 1-676 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human direct interaction direct interaction s-9 2 8 unspecified role unspecified role unspecified role unspecified role S1 domain Region 1-676 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human covalent binding covalent binding s-dpp4-2 1 9 unspecified role unspecified role prey prey Region 39-766 Region 39-766 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 6 unspecified role unspecified role bait bait S1 domain Region 1-747 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human direct interaction direct interaction s-10 4 6 unspecified role unspecified role unspecified role unspecified role S1 domain Region 1-747 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain Fc-tag Fc-tag fc-igg tag fc-igg tag c-term range C-terminal range c-term range c-term range C-terminal range c-term range human Homo sapiens Human covalent binding covalent binding