DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. Only protein-protein interactions in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. DIP original experiment: DIP-253631X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. Only protein-protein interactions in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. DIP original experiment: DIP-253633X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. Only protein-protein interactions in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. DIP original experiment: DIP-253632X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. DIP original experiment: DIP-253628X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. Only protein-protein interactions in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. DIP original experiment: DIP-253629X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. Proceedings of the National Academy of Sciences of the United States of America 2012 imex curation Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. Only protein-protein interactions in vitro In vitro tem transmission electron microscopy tem predetermined predetermined participant predetermined Liu C., Zhao M., Jiang L., Cheng PN., Park J., Sawaya MR., Pensalfini A., Gou D., Berk AJ., Glabe CG., Nowick J., Eisenberg D. DIP original experiment: DIP-253630X Proceedings of the National Academy of Sciences of the United States of America 2012 IMEx Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates. abeta(3036) Amyloid beta peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) AIIGLMV nflvhs IAAP peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) NFLVHS iapp(2833) IAPP peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide in vitro In vitro SSTNVG beta2m(5863) Beta2-microglobulin peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) KDWSFY tau(305310) Tau peptide peptide peptide polypeptide oligopeptide oligopeptide polypeptide chemical synthesis Chemical synthesis (Chemical synthesis) SVQIVYK iapp(2833)-1 3 9 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction beta2m(5863)-1 4 10 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction abeta(3036)-1 2 7 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction beta2m(5863)-2 5 10 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction tau(305310)-1 6 11 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction iapp(1419)-1 1 8 unspecified role unspecified role unspecified role unspecified role in vitro In vitro direct interaction direct interaction