DIP Database of Interacting Proteins 611 Young Drive East; Los Angeles CA 90095; USA http://dip.doe-mbi.ucla.edu/ dip@mbi.ucla.edu Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nature structural & molecular biology 2012 imex curation Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. DIP original experiment: DIP-251378X Nature structural & molecular biology 2012 IMEx Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nature structural & molecular biology 2012 imex curation Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. DIP original experiment: DIP-251375X Nature structural & molecular biology 2012 IMEx Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nature structural & molecular biology 2012 imex curation Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. DIP original experiment: DIP-251374X Nature structural & molecular biology 2012 IMEx Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nature structural & molecular biology 2012 imex curation Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. Only protein-protein interactions human Homo sapiens Human x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. DIP original experiment: DIP-251376X Nature structural & molecular biology 2012 IMEx Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nature structural & molecular biology 2012 imex curation Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. Only protein-protein interactions in vitro In vitro x-ray diffraction x-ray crystallography X-ray X-ray x-ray diffraction predetermined predetermined participant predetermined Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. DIP original experiment: DIP-251373X Nature structural & molecular biology 2012 IMEx Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. Nature structural & molecular biology 2012 imex curation Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. Only protein-protein interactions in vitro In vitro spr surface plasmon resonance Optical biosensor BIAcore(r) BIAcore(r) Optical biosensor spr predetermined predetermined participant predetermined Janssen BJ., Malinauskas T., Weir GA., Cader MZ., Siebold C., Jones EY. DIP original experiment: DIP-251377X Nature structural & molecular biology 2012 IMEx Neuropilins lock secreted semaphorins onto plexins in a ternary signaling complex. nrp1_mouse Neuropilin-1 A5 protein Nrp1 Nrp protein protein mouse Mus musculus Mouse MERGLPLLCATLALALALAGAFRSDKCGGTIKIENPGYLTSPGYPHSYHPSEKCEWLIQAPEPYQRIMINFNPHFDLEDRDCKYDYVEVIDGENEGGRLWGKFCGKIAPSPVVSSGPFLFIKFVSDYETHGAGFSIRYEIFKRGPECSQNYTAPTGVIKSPGFPEKYPNSLECTYIIFAPKMSEIILEFESFDLEQDSNPPGGMFCRYDRLEIWDGFPEVGPHIGRYCGQKTPGRIRSSSGVLSMVFYTDSAIAKEGFSANYSVLQSSISEDFKCMEALGMESGEIHSDQITASSQYGTNWSVERSRLNYPENGWTPGEDSYKEWIQVDLGLLRFVTAVGTQGAISKETKKKYYVKTYRVDISSNGEDWISLKEGNKAIIFQGNTNPTDVVLGVFSKPLITRFVRIKPVSWETGISMRFEVYGCKITDYPCSGMLGMVSGLISDSQITASNQADRNWMPENIRLVTSRTGWALPPSPHPYTNEWLQVDLGDEKIVRGVIIQGGKHRENKVFMRKFKIAYSNNGSDWKTIMDDSKRKAKSFEGNNNYDTPELRTFSPLSTRFIRIYPERATHSGLGLRMELLGCEVEAPTAGPTTPNGNPVDECDDDQANCHSGTGDDFQLTGGTTVLATEKPTIIDSTIQSEFPTYGFNCEFGWGSHKTFCHWEHDSHAQLRWSVLTSKTGPIQDHTGDGNFIYSQADENQKGKVARLVSPVVYSQSSAHCMTFWYHMSGSHVGTLRVKLRYQKPEEYDQLVWMVVGHQGDHWKEGRVLLHKSLKLYQVIFEGEIGKGNLGGIAVDDISINNHISQEDCAKPTDLDKKNTEIKIDETGSTPGYEGEGEGDKNISRKPGNVLKTLDPILITIIAMSALGVLLGAVCGVVLYCACWHNGMSERNLSALENYNFELVDGVKLKKDKLNPQSNYSEA DIP protein P97333 original sequence version: 97 DIP protein P97333 original sequence version: 116 DIP protein P97333 original sequence version: 123 23209818C5C42137 sem3a_mouse Semaphorin-3A Sema3a Semad SemD Semaphorin III Semaphorin-D protein protein mouse Mus musculus Mouse MGWFTGIACLFWGVLLTARANYANGKNNVPRLKLSYKEMLESNNVITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDECKWAGKDILKECANFIKVLEAYNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDSHFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDSRWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGHRSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNIFKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDSTKDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVDRVDAEDGQYDVMFIGTDVGTVLKVVSVPKETWHDLEEILLEEMTVFREPTTISAMELSTKQQQLYIGSTAGVAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRRQDIRNGDPLTHCSDLQHHDNHHGPSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRKEEIRMGDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELLHKDDDGDGSKIKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGHSQGSSNKWKHMQESKKGRNRRTHEFERAPRSV DIP protein O08665 original sequence version: 119 mint Plays a role in growth cones guidance. May function to pattern sensory projections by selectively repelling axons that normally terminate dorsally C6533FF007018D0C plxa2_mouse Plexin-A2 Plxna2 Kiaa0463 protein protein mouse Mus musculus Mouse MEQRRFYLRAMQADNLSVVLLSVAWLLLARGTTGMPQYSTFHSENRDWTFNHLTVHRRTGAVYVGAINRVYKLTGNLTIQVAHKTGPEEDNKACYPPLIVQPCSEVLTLTNNVNKLLIIDYSENRLLACGSLYQGVCKLLRLDDLFILVEPSHKKEHYLSSVNKTGTMYGVIVRSEGEDGKLFIGTAVDGKQDYFPTLSSRKLPRDPESSAMLDYELHSDFVSSLIKIPSDTLALVSHFDIFYIYGFASGGFVYFLTVQPETPDGMAINSAGDLFYTSRIVRLCKDDPKFHSYVSLPFGCTRAGVEYRLLQAAYLAKPGEALAQAFNISSDEDVLFAIFSKGQKQYHHPPDDSALCAFPIRAINLQIKERLQSCYHGEGNLELNWLLGKDVQCTKAPVPIDDNFCGLDINQPLGGSTPVEGLTLYTTSRDRLTSVASYVYNGYSVVFVGTKSGKLKKIRADGPPHGGVQYEMVSVFKDGSPILRDMAFSINQLYLYVMSERQVTRVPVESCEQYTTCGECLSSGDPHCGWCALHNMCSRRDKCQRAWEANRFAASISQCMSLEVHPNSISVSDHSRLLSLVVNDAPNLSEGIACAFGNLTEVEGQVSGSQVICISPGPKDVPVIPLDQDWFGLELQLRSKETGKIFVSTEFKFYNCSAHQLCLSCVNSAFRCHWCKYRNLCTHDPTTCSFQEGRINVSEDCPQLVPTEEILIPVGEVKPITLKARNLPQPQSGQRGYECVLSIQGAVHRVPALRFNSSSVQCQNSSYQYDGMDISNLAVDFAVVWNGNFIIDNPQDLKVHLYKCAAQRESCGLCLKADHKFECGWCSGERRCTLHQHCPSTSSPWLDWSSHNVKCSNPQITEILTVSGPPEGGTRVTIHGVNLGLDFSEIAHHVQVAGVPCTPIPGEYIIAEQIVCEMGHAVIGTTSGPVRLCIGECKPEFMTKSHQQYTFVNPSVLSLSPIRGPESGGTMVTITGHYLGAGSSVAVYLGNQTCEFYGRSMNEIVCVSPPSSNGLGPVPVSVSVDRARVDSSLQFEYIDDPRVQRIEPEWSITSGHTPLTITGFNLDVIQEPRVRVKFNGKESVNVCTVVNTTTLTCLAPSLTSDYRPGLDTVERPDEFGFLFNNVQSLLIYNDTKFIYYPNPTFELLSPTGILDQKPGSPIILKGKNLCPPASGGAKLNYTVMIGETPCTVTVSETQLLCEPPNLTGQHKVMVHVGGMVFSPGSVSVISDSLLTLPAIISIAAGGSLLLIIVIIVLIAYKRKSRENDLTLKRLQMQMDNLESRVALECKEAFAELQTDINELTSDLDRSGIPYLDYRTYAMRVLFPGIEDHPVLRELEVQGNGQQHVEKALKLFAQLINNKVFLLTFIRTLELQRSFSMRDRGNVASLIMTGLQGRLEYATDVLKQLLSDLIDKNLENKNHPKLLLRRTESVAEKMLTNWFAFLLHKFLKECAGEPLFMLYCAIKQQMEKGPIDAITGEARYSLSEDKLIRQQIEYKTLILNCVNPDNENSPEIPVKVLNCDTITQVKEKILDAVYKNVPYSQRPRAVDMDLEWRQGRIARVVLQDEDITTKIEGDWKRLNTLMHYQVSDRSVVALVPKQTSSYNIPASASISRTSISRYDSSFRYTGSPDSLRSRVPMITPDLESGVKVWHLVKNHDHGDQKEGDRGSKMVSEIYLTRLLATKGTLQKFVDDLFETLFSTVHRGSALPLAIKYMFDFLDEQADRHSIHDTDVRHTWKSNCLPLRFWVNVIKNPQFVFDIHKGSITDACLSVVAQTFMDSCSTSEHRLGKDSPSNKLLYAKDIPSYKNWVERYYADIAKLPAISDQDMNAYLAEQSRLHATEFNMLSALNEIYSYVSKYSEELIGALEQDEQARRQRLAYKVEHLINAMSIES DIP protein P70207 original sequence version: 74 DIP protein P70207 original sequence version: 90 9F6C34F48BC29CEE nrp1-plxna2-2 5 8 unspecified role unspecified role unspecified role unspecified role Region 21-555 Region 21-555 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 7 unspecified role unspecified role unspecified role unspecified role Region 22-586 Region 22-586 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 9 unspecified role unspecified role unspecified role unspecified role Region 35-703 Region 35-703 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction plxna2-nrp1-1 2 7 unspecified role unspecified role prey prey Region 22-586 Region 22-586 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 9 unspecified role unspecified role bait bait Region 35-703 Region 35-703 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P70207:p.Phe275Asn F275N mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain F N This feature has been corrected as a result of our quality control procedures. The original label was 'F275N'. Wed May 02 19:38:21 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'phe275asn' Tue Jun 30 15:55:54 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.Phe275Asn' human Homo sapiens Human direct interaction direct interaction plxna2-nrp1-2 6 7 unspecified role unspecified role prey prey Region 22-586 Region 22-586 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P97333:p.[Pro73Ala;His74Ser] P73A/H74S mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain H S certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P73A/H74S'. Wed May 02 18:56:55 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro73ala,his74ser' Tue Jun 30 16:43:59 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Pro73Ala;His74Ser]' human Homo sapiens Human 9 unspecified role unspecified role bait bait Region 35-703 Region 35-703 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction nrp1-sema3a-1 3 8 unspecified role unspecified role prey prey Region 21-568 Region 21-568 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human 7 unspecified role unspecified role bait bait Region 22-586 Region 22-586 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain P97333:p.[Pro73Ala;His74Ser] P73A/H74S mutation disrupting strength mutation disrupting interaction strength mutation disrupting strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain H S certain certain sequence position certain certain certain sequence position certain P A This feature has been corrected as a result of our quality control procedures. The original label was 'P73A/H74S'. Wed May 02 16:29:13 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'pro73ala,his74ser' Tue Jun 30 17:23:47 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Pro73Ala;His74Ser]' human Homo sapiens Human direct interaction direct interaction sema3a-1 4 8 unspecified role unspecified role unspecified role unspecified role Region 21-675 Region 21-675 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain O08665:p.[Arg551Ala;Arg555Ala] R551A/R555A mutation mutation certain certain sequence position certain certain certain sequence position certain R A certain certain sequence position certain certain certain sequence position certain R A This feature has been corrected as a result of our quality control procedures. The original label was 'R551A/R555A'. Wed May 02 15:00:48 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'arg551ala,arg555ala' Tue Jun 30 18:34:43 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Arg551Ala;Arg555Ala]' human Homo sapiens Human direct interaction direct interaction nrp1-sema3a-2 1 8 unspecified role unspecified role prey prey Region 21-568 Region 21-568 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain O08665:p.[Leu353Asn;Pro355Ser] L353N/P355S mutation decreasing strength mutation decreasing interaction strength mutation decreasing strength substitut analysis substitution analysis substitut analysis certain certain sequence position certain certain certain sequence position certain P S certain certain sequence position certain certain certain sequence position certain L N This feature has been corrected as a result of our quality control procedures. The original label was 'L353N/P355S'. Wed May 02 19:13:36 BST 2018 This feature has been corrected as a result of our quality control procedures. The original label was 'leu353asn,pro355ser' Tue Jun 30 18:38:20 BST 2020 This feature has been corrected as a result of our quality control procedures. The original label was 'p.[Leu353Asn;Pro355Ser]' human Homo sapiens Human 7 unspecified role unspecified role bait bait Region 22-586 Region 22-586 sufficient to bind sufficient binding region sufficient to bind certain certain sequence position certain certain certain sequence position certain human Homo sapiens Human direct interaction direct interaction